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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CNOT6 Gene

protein-coding GIFtS: 57
GCID: GC05P179921

CCR4-NOT transcription complex, subunit 6

Explore 4 diseases affiliated with
CNOT6 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
CCR4-NOT Transcription Complex, Subunit 6¹ ²		Carbon Catabolite Repression 4 Protein²
CCR4¹ ² ³ ⁵		CCR4-NOT Transcription Complex Subunit 6²
KIAA1194¹ ³ ⁵		EC 3.1.-.-³
Carbon Catabolite Repressor Protein 4 Homolog² ³		CCR4 Carbon Catabolite Repression 4-Like³
Cytoplasmic Deadenylase² ³		EC 3.1.13.4⁸

External Ids:	HGNC: 14099¹	Entrez Gene: 57472²	Ensembl: ENSG00000113300⁷	OMIM: 608951⁵	UniProtKB: Q9ULM6³

Export aliases for CNOT6 gene to outside databases

Previous GC identifers: GC00U990842 GC05P179855 GC05P179856 GC05P174644

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CNOT6:

The protein encoded by this gene is a subunit of the CCR4-NOT core transcriptional regulation complex. The encoded

protein has a 3'-5' RNase activity and prefers polyadenylated substates. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CNOT6_HUMAN, Q9ULM6

Function: Poly(A) nuclease involved in mRNA decay mediated by the major-protein-coding determinant of instability

(mCRD) of the FOS gene in the cytoplasm. Has 3'-5' RNase activity. The CCR4-NOT complex functions as general

transcription regulation complex (By similarity). In the presence of ZNF335, enhances ligand-dependent transcriptional

activity of nuclear hormone receptors, including RARA. The increase of ligand-dependent ESR1-mediated transcription is

much smaller, if any

summary for CNOT6:

Chemokines (chemotactic cytokines) belong to a family of chemoattractant molecules involved in the directed

migration of immune cells. Over fifty human chemokines have been identified that can be categorised into

four groups; CC, CXC, CX3C and C (XCL1 and XCL2); depending on the spacing of their first two cysteine

residues. Chemokines exert their effects by binding to G-protein-coupled chemokine receptors on the surface

of cells, predominantly leukocytes. Eighteen human chemokine receptors have been identified that are

classified according to the class of chemokines that they bind. The major function of chemokines is to

regulate leukocyte trafficking in hematopoiesis and in innate and adaptive immunity. Other functions include

angiogenic activity, apoptosis, T-cell differentiation and phagocyte activation. Inadvertent activation of

chemokine receptors leads to autoimmunity by inappropriately targeting self antigens for destruction by

cytotoxic T-cells and macrophages.

Gene Wiki entry for CNOT6

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000005.9 NC_018916.1 NT_023133.13

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CNOT6 gene promoter:
AP-2rep FOXF2 AP-4 E47 RORalpha1 FOXJ2 (long isoform) Hand1 FOXO1a FOXJ2 FOXO1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CNOT6 promoter sequence

Search SABiosciences Chromatin IP Primers for CNOT6

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CNOT6

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q35.3 Ensembl cytogenetic band: 5q35.3 HGNC cytogenetic band: 5q35.3

CNOT6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CNOT6 gene location

GeneLoc information about chromosome 5 GeneLoc Exon Structure

GeneLoc location for GC05P179921: view genomic region (about GC identifiers)

Start:	179,921,412 bp from pter	End:	180,005,405 bp from pter
Size:	83,994 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CNOT6_HUMAN, Q9ULM6 (See protein sequence)

Recommended Name: CCR4-NOT transcription complex subunit 6

Size: 557 amino acids; 63307 Da

Cofactor: Magnesium

Subunit: Subunit of the CCR4-NOT core complex that contains CHAF1A, CHAF1B, CNOT1, CNOT2, CNOT3, CNOT4, CNOT6 and

CNOT8. Interacts with UNR. Interacts with ZNF335

Subcellular location: Cytoplasm (Probable). Nucleus (Probable)

Secondary accessions: A7MD46 D3DWR0

Explore the universe of human proteins at neXtProt for CNOT6: NX_Q9ULM6

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9ULM6

2 DME Specific Peptides for CNOT6 (Q9ULM6)

PKSRARTM

NRVMTKDNI

CNOT6 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_056270.2

ENSEMBL proteins:

ENSP00000377024 ENSP00000422087 ENSP00000261951

Reactome Protein details: Q9ULM6
Human Recombinant Protein Products for CNOT6:

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	Uscn Proteins for CNOT6

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--
GO:0005829	cytosol	TAS	--

CNOT6 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CNOT6 for domains About GeneDecksing

3 InterPro domains/families:

IPR001611 Leu-rich_rpt

IPR003591 Leu-rich_rpt_typical-subtyp

IPR005135 Endo/exonuclease/phosphatase

Graphical View of Domain Structure for InterPro Entry Q9ULM6

ProtoNet protein and cluster: Q9ULM6

UniProtKB/Swiss-Prot: CNOT6_HUMAN, Q9ULM6

Similarity: Belongs to the CCR4/nocturin family

Similarity: Contains 4 LRR (leucine-rich) repeats

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: CNOT6_HUMAN, Q9ULM6

Function: Poly(A) nuclease involved in mRNA decay mediated by the major-protein-coding determinant of instability

(mCRD) of the FOS gene in the cytoplasm. Has 3'-5' RNase activity. The CCR4-NOT complex functions as general

transcription regulation complex (By similarity). In the presence of ZNF335, enhances ligand-dependent transcriptional

activity of nuclear hormone receptors, including RARA. The increase of ligand-dependent ESR1-mediated transcription is

much smaller, if any

Enzyme Numbers (IUBMB): EC 3.1.-.-¹ EC 3.1.13.4²

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003723	RNA binding	IEA	--
GO:0004535	poly(A)-specific ribonuclease activity	TAS	--
GO:0005515	protein binding	IPI	18180299
GO:0046872	metal ion binding	IEA	--

CNOT6 for ontologies About GeneDecksing

Animal Models:

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CNOT6

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Deadenylation-dependent mRNA decay

	Deadenylation-dependent mRNA decay	1.00			Deadenylation of mRNA	0.47
	RNA degradation	0.50

Metabolism of mRNA

Metabolism of mRNA

1.00

Metabolism of RNA

0.92

Generic Transcription Pathway

Gene Expression

0.46

Pathway sources
See GeneCards unified pathways
Show all pathways

5 Reactome Pathways for CNOT6

	Deadenylation of mRNA
	Deadenylation-dependent mRNA decay
	Metabolism of RNA
	Metabolism of mRNA
	Gene Expression

1 Kegg Pathway (Kegg details for CNOT6):

RNA degradation

CNOT6 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for CNOT6

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/127 Interacting proteins for CNOT6 (Q9ULM6³ ENSP00000261951⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 127)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CNOT8	Q9UFF9³, ENSP00000285896⁴	I2D: score=8 STRING: ENSP00000285896
CNOT1	A5YKK6³, ENSP00000320949⁴	STRING: ENSP00000320949 I2D: score=6
CNOT3	O75175³, ENSP00000221232⁴	I2D: score=5 STRING: ENSP00000221232
CNOT2	Q9NZN8³, ENSP00000229195⁴	I2D: score=1 STRING: ENSP00000229195
FEN1	P39748³, ENSP00000305480⁴	I2D: score=1 STRING: ENSP00000305480

About this table

Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000288	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	TAS	--
GO:0000289	nuclear-transcribed mRNA poly(A) tail shortening	TAS	--
GO:0006351	transcription, DNA-dependent	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	IEA	--
GO:0010467	gene expression	TAS	--

CNOT6 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Compounds for CNOT6 available from Tocris Bioscience About this table

Compound	Action	CAS #
C 021 dihydrochloride	Potent CCR4 antagonist	[864289-85-0]

1 HMDB Compound for CNOT6 About this table

Compound	Synonyms	CAS #	PubMed Ids
Magnesium	Magnesium (see all 2)	7439-95-4	--

Search CenterWatch for drugs/clinical trials and news about CNOT6

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CNOT6 gene:

NM_015455.3

Unigene Cluster for CNOT6:

CCR4-NOT transcription complex, subunit 6

Hs.608380 [show with all ESTs]

Unigene Representative Sequence: BC152469

6 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000510148 ENST00000393356(uc010jld.3) ENST00000507016 ENST00000502447

ENST00000504343 ENST00000261951(uc003mlx.3 uc010jle.3)

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Additional cDNA sequence:

AB033020.1 AK023599.1 AK314752.1 AL110144.1 BC015331.1 BC027476.1 BC073142.1 BC090918.1

BC114958.1 BC152469.1

10 DOTS entries:

DT.115578 DT.101979531 DT.99934212 DT.100775630 DT.101957004 DT.92435297 DT.92435303 DT.95345830

DT.100737457 DT.97799052

268 AceView cDNA sequences (see top 24):

CA314233 AA983617 AA884340 CR617731 AW128938 AA603028 AA251375 AI201258

AA459219 AA227814 F03677 BG231763 BM678534 BQ029496 CB306950 BU161680

AI028199 AW173692 AA115459 CA416373 N90713 AA235905 BQ232180 BM974097

AA948530 BE887434 AA227992 AB033020 AI659480 AA227818 W47579 W91904

CB243439 CA429543 AI671870 N42835 BQ219821 BM682186 BU189165 CB959839

AA630737 AA479504 AI744474 AA227943 AI187427 BP379655 AA478586 AA361774

BU676333 AA835643 AW304095 AA721414 CB132879 BU167426 AI204655 AA633196

BM974261 AI810439 BQ213095 AI005662 BF940524 CR601971 BU193854 BM976591

CB150547 NM_015455 Z41386 BE897352 AA971246 BF476475 BM055021 BC027476

AI276566 BM729275 AA975292 AW614446 BG291571 CB134449 AL040876 AK023599

AA459000 AW572656 BM722021 AA251622 BM263928 BM452984 AA098915 BF916326

AL537169 AW183847 AI084832 AA332344 BU180647 AL529286 BX504509 N29146

BU177207 BQ433700 AU141055 CD654531 CB137373 BM974795 CA777868 AA479323

AI554034 AW979198 AI280050 BQ438062 BU608759 CA427331 BE935944 BI493662

BU156391 AW339986 AU137463 AI289614 BX115541 BE007800 BU187665 BQ214953

AA479501 BU160344 AA860948 AI025725 BC073142 CA944530 AI421025 AA235904

AW749984 AI935999 CB107126 AI401342 AI221941 BI088505 W92046 BG388757

BF223837 AI972933 BM463663 BG541240 AW079091 AA825604 BM693577 CA449523

BU162173 AL110144 AI569899 AA889448 BU508164 AW117476 BI093514 BE089434

BU607417 BI093150 BQ015736 CA778132 BM462451 AU134079 AW263640 AI239707

BM264229 D20789 BF772009 AI201876 AA911713 AA431856 AA442396 BM828143

AW272482 BM475600 AL711460 BF171964 N23326 CA445247 CD641654 AI683048

N32487 CA397427 AI813466 AV735169 Z44636 AA612699 AA431857 BG505812

AA835874 BE926053 F08390 AA150191 CF135521 AI933147 BG110699 BF772441

AW511057 CF121570 BE936032 AA285267 BI494313 AL603373 CB048374 BF373772

AW188843 N53594 AW043695 AI829051 BU679446 AL698594 AW087428 BG259351

AA150367 BE786547 AA612709 W47600 CA311373 N34374 AI798092 N22623

BF768671 AI811339 AI669732 BM769589 AI356219 CD684108 BE544290 BF988677

AA558320 BM852471 T93512 AW293221 BF209885 AA099264 AA857490 BU533252

W46194 BX431157 CF144140 BE548782 W46368 AW968409 AA026743 W20270

AU157187 AW965316 AV716259 T93534 BE568552 BE180051 BE869218 AA533108

BM055298 CB117136 BF926984 AL529285 AW968421 T47862 N51454 AW968414

BC015331 BG257950 BE086227 BE065570 BE065561 AL537168 BE011738 R57651

BE004758 CB157645 BG249723 AW883729

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for CNOT6 (see all 7) About this scheme

ExUns:	1	^	2a	·	2b	·	2c	·	2d	^	3	^	4a	·	4b	^	5a	·	5b	^	6a	·	6b	^	7	^	8a	·	8b	^	9a	·	9b	·	9c	^	10	^	11	^	12	^	13
SP1:			-		-		-		-																-				-
SP2:																									-
SP3:											-
SP4:
SP5:											-										-		-		-

ECgene alternative splicing isoforms for CNOT6

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CNOT6 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGTCTTCCGT

About this image
See CNOT6 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CNOT6

SOURCE GeneReport for Unigene cluster: Hs.608380
SABiosciences Custom PCR Arrays for CNOT6

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for CNOT6 gene from 8/26 species (see all 26) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Cnot6^{1 , 5}	CCR4-NOT transcription complex, subunit 6^{1, 5}	92.27(n)¹ 96.01(a)¹		11 (29.76 cM)⁵ 104625¹ NM_212484.1¹ NP_997649.1¹ 49671503⁵
chicken (Gallus gallus)	Aves	CNOT6¹	CCR4-NOT transcription complex, subunit 6	86.18(n) 95.69(a)		416293 XM_414612.3 XP_414612.3
lizard (Anolis carolinensis)	Reptilia	CNOT6⁶	--	93(a)	1 ↔ 1	2(141011047-141038653)
zebrafish (Danio rerio)	Actinopterygii	Dr.24978²	Danio rerio mRNA similar to KIAA1194 (cDNA clone IMAGE5413 more	78.97(n)		BC058309.1
fruit fly (Drosophila melanogaster)	Insecta	twin¹	CG31137-PA	59.3(n) 59.05(a)		42880 NM_170128.1 NP_732964.1
worm (Caenorhabditis elegans)	Secernentea	ccr-4¹	Protein CCR-4	57.1(n) 51.76(a)		178184 NM_001028437.1 NP_001023608.1
thale cress (Arabidopsis thaliana)	eudicotyledons	AT3G58560⁶ AT3G58580⁶	carbon catabolite repressor protein 4-like 2	23(a) 21(a)	many ↔ many many ↔ many	3(21650596-21654200) 3(21660598-21664095)
rice (Oryza sativa)	Liliopsida	-- --	endonuclease/exonuclease/phosphatase family domain... endonuclease/exonuclease/phosphatase family domain...	22(a) 21(a)	many ↔ many many ↔ many	3(3615603-3621204) 10(14285713-14291210)

ENSEMBL Gene Tree for CNOT6 (if available)
TreeFam Gene Tree for CNOT6 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CNOT6 gene

ANGEL1² CCRN4L² PDE12² CNOT6L² ANGEL2²

1 SIMAP similar gene for CNOT6 using alignment to 3 protein entries: CNOT6_HUMAN (see all proteins):

CNOT6L

CNOT6 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 5 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs67559229^1,2		--	174650431(+)	`CCCCCC/TTTTTT`	1	--	int¹		1		CSA	2
rs34629311^1,2	C	--	174702887(+)	`CTGCT-/GTTATTTT`	1	--	int¹		1		NA	2
rs73363219^1,2	C,F	--	179919427(+)	`CCGCAC/TAACTC`	1	--	us2k¹		1		WA	118
rs141118409^1,2		--	179919464(+)	`GGGATG/TGCCAC`	1	--	us2k¹		0	--	--	--	--
rs56755455^1,2	C	--	179919468(+)	`TGGCCA/CCAGGC`	1	--	us2k¹		4		NA WA EA	360
rs182840291^1,2		--	179919550(+)	`ATGGCA/GCTAGA`	1	--	us2k¹		0	--	--	--	--
rs150269797^1,2		--	179919589(+)	`GCAGTA/GCCAAG`	1	--	us2k¹		0	--	--	--	--
rs62405496^1,2	C,F	--	179919618(+)	`CGTGCT/CGGGGA`	1	--	us2k¹		6		NA WA EA	364
rs62405497^1,2	C	--	179919912(+)	`ATATAG/CCTCAA`	1	--	us2k¹		7		NA WA EA	366
rs10072835^1,2	C,F	--	179919913(+)	`TATAGC/GTCAAA`	1	--	us2k¹		2		WA NA	238

HapMap Linkage Disequilibrium report for CNOT6 (179921412 - 180005405 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for CNOT6
1 CNV: 51654

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CNOT6 for disorders           About GeneDecksing

OMIM gene information: 608951    OMIM disorders: --

4 diseases for CNOT6:    About MalaCards

food allergy twinning malaria alcoholism

1 Novoseek disease relationship for CNOT6 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
tumors	0	1	17641067 (1)

Export disorders for CNOT6 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for CNOT6 gene, integrated from 9 sources (see all 38):
(articles sorted by number of sources associating them with CNOT6)

Utopia: connect your pdf to the dynamic
world of online information

CCR4, a 3'-5' poly(A) RNA and ssDNA exonuclease, is the catalytic component of the cytoplasmic deadenylase. (PubMed id 11889047)^{1, 2, 3} Chen J.... Denis C.L. (2002)
Components of the CCR4-NOT complex function as nuclear hormone receptor coactivators via association with the NRC-interacting Factor NIF-1. (PubMed id 18180299)^{1, 2, 9} Garapaty S....Samuels H.H. (2008)
UNR, a new partner of poly(A)-binding protein, plays a key role in translationally coupled mRNA turnover mediated by the c-fos major coding-region determinant. (PubMed id 15314026)^{1, 2, 9} Chang T.-C.... Shyu A.-B. (2004)
Identification of four families of yCCR4- and Mg2+-dependent endonuclease-related proteins in higher eukaryotes, and characterization of orthologs of yCCR4 with a conserved leucine-rich repeat essential for hCAF1/hPOP2 binding. (PubMed id 11747467)^{1, 2} Dupressoir A....Heidmann T. (2001)
Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10574462)^{1, 2} Nagase T.... Ohara O. (1999)
Isolation and characterization of human orthologs of yeast CCR4-NOT complex subunits. (PubMed id 10637334)^{1, 9} Albert T.K....Timmers H.T. (2000)
Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)¹ Udeshi N.D....Carr S.A. (2012)
Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)¹ Danielsen J.M....Nielsen M.L. (2011)
The Ccr4a (CNOT6) and Ccr4b (CNOT6L) deadenylase subu nits of the human Ccr4-Not complex contribute to the prevention of cell death a nd senescence. (PubMed id 21233283)¹ Mittal S....Winkler G.S. (2011)
Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)¹ Kim W....Gygi S.P. (2011)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 57472	HGNC: 14099	AceView: KIAA1194	Ensembl:ENSG00000113300	euGenes: HUgn57472
ECgene: CNOT6	Kegg: 57472	H-InvDB: CNOT6

(According to HUGE)
About This Section

HUGE: KIAA1194

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CNOT6	Pharmacogenomics, SNPs, Pathways

Intellectual Property for CNOT6 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for CNOT6 gene:
Search GeneIP for patents involving CNOT6

GeneCards and IP:
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CNOT6 Gene

CCR4-NOT transcription complex, subunit 6

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CNOT6 Gene

CCR4-NOT transcription complex, subunit 6

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