Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CNOT6 Gene

protein-coding   GIFtS: 57
GCID: GC05P179921

CCR4-NOT transcription complex, subunit 6
 Explore 4 diseases affiliated with
CNOT6 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CNOT6    

Aliases
for CNOT6 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
CCR4-NOT Transcription Complex, Subunit 61 2     Carbon Catabolite Repression 4 Protein2
CCR41 2 3 5     CCR4-NOT Transcription Complex Subunit 62
KIAA11941 3 5     EC 3.1.-.-3
Carbon Catabolite Repressor Protein 4 Homolog2 3     CCR4 Carbon Catabolite Repression 4-Like3
Cytoplasmic Deadenylase2 3     EC 3.1.13.48

External Ids:    HGNC: 140991   Entrez Gene: 574722   Ensembl: ENSG000001133007   OMIM: 6089515   UniProtKB: Q9ULM63   

Export aliases for CNOT6 gene to outside databases

Previous GC identifers: GC00U990842 GC05P179855 GC05P179856 GC05P174644


Summaries
for CNOT6 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CNOT6:
The protein encoded by this gene is a subunit of the CCR4-NOT core transcriptional regulation complex. The encoded
protein has a 3'-5' RNase activity and prefers polyadenylated substates. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CNOT6_HUMAN, Q9ULM6
Function: Poly(A) nuclease involved in mRNA decay mediated by the major-protein-coding determinant of instability
(mCRD) of the FOS gene in the cytoplasm. Has 3'-5' RNase activity. The CCR4-NOT complex functions as general
transcription regulation complex (By similarity). In the presence of ZNF335, enhances ligand-dependent transcriptional
activity of nuclear hormone receptors, including RARA. The increase of ligand-dependent ESR1-mediated transcription is
much smaller, if any

summary for CNOT6:
Chemokines (chemotactic cytokines) belong to a family of chemoattractant molecules involved in the directed
migration of immune cells. Over fifty human chemokines have been identified that can be categorised into
four groups; CC, CXC, CX3C and C (XCL1 and XCL2); depending on the spacing of their first two cysteine
residues. Chemokines exert their effects by binding to G-protein-coupled chemokine receptors on the surface
of cells, predominantly leukocytes. Eighteen human chemokine receptors have been identified that are
classified according to the class of chemokines that they bind. The major function of chemokines is to
regulate leukocyte trafficking in hematopoiesis and in innate and adaptive immunity. Other functions include
angiogenic activity, apoptosis, T-cell differentiation and phagocyte activation. Inadvertent activation of
chemokine receptors leads to autoimmunity by inappropriately targeting self antigens for destruction by
cytotoxic T-cells and macrophages.

Gene Wiki entry for CNOT6


Genomic Views
for CNOT6 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.1  NT_023133.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CNOT6 gene promoter:
         AP-2rep   FOXF2   AP-4   E47   RORalpha1   FOXJ2 (long isoform)   Hand1   FOXO1a   FOXJ2   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CNOT6 promoter sequence
   Search SABiosciences Chromatin IP Primers for CNOT6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CNOT6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q35.3   Ensembl cytogenetic band:  5q35.3   HGNC cytogenetic band: 5q35.3

CNOT6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CNOT6 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P179921:  view genomic region     (about GC identifiers)

Start:
 179,921,412 bp from pter      End:
 180,005,405 bp from pter
Size:
 83,994 bases      Orientation:
 plus strand

Proteins
for CNOT6 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CNOT6_HUMAN, Q9ULM6 (See protein sequence)
Recommended Name: CCR4-NOT transcription complex subunit 6  
Size: 557 amino acids; 63307 Da
Cofactor: Magnesium
Subunit: Subunit of the CCR4-NOT core complex that contains CHAF1A, CHAF1B, CNOT1, CNOT2, CNOT3, CNOT4, CNOT6 and
CNOT8. Interacts with UNR. Interacts with ZNF335
Subcellular location: Cytoplasm (Probable). Nucleus (Probable)
Secondary accessions: A7MD46 D3DWR0

Explore the universe of human proteins at neXtProt for CNOT6: NX_Q9ULM6

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9ULM6

    • 2 DME Specific Peptides for CNOT6 (Q9ULM6)
     PKSRARTM  NRVMTKDNI 

    CNOT6 Protein expression data from MOPED and PaxDb:    About this image 
    CNOT6 Protein Expression
    REFSEQ proteins: NP_056270.2  
    ENSEMBL proteins: 
     ENSP00000377024   ENSP00000422087   ENSP00000261951  
    Reactome Protein details: Q9ULM6
    Human Recombinant Protein Products for CNOT6: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom Protein Services for CNOT6 
    GenScript Custom Purified and Recombinant Proteins Services for CNOT6
    Novus Biologicals CNOT6 Proteins
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for CNOT6

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005829cytosol TAS--

    CNOT6 for ontologies           About GeneDecksing



    CNOT6 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for CNOT6 
    GenScript Custom Superior Antibodies Services for CNOT6
    Novus Biologicals CNOT6 Antibodies
    Abcam antibodies for CNOT6 
    Uscn Antibodies for CNOT6
    Search ThermoFisher Antibodies for CNOT6

    Assay Products for CNOT6: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CNOT6
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for CNOT6

    Protein Domains /
    Families
    for CNOT6 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CNOT6 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR001611 Leu-rich_rpt
     IPR003591 Leu-rich_rpt_typical-subtyp
     IPR005135 Endo/exonuclease/phosphatase

    Graphical View of Domain Structure for InterPro Entry Q9ULM6

    ProtoNet protein and cluster: Q9ULM6

    UniProtKB/Swiss-Prot: CNOT6_HUMAN, Q9ULM6
    Similarity: Belongs to the CCR4/nocturin family
    Similarity: Contains 4 LRR (leucine-rich) repeats


    Function
    for CNOT6 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CNOT6_HUMAN, Q9ULM6
    Function: Poly(A) nuclease involved in mRNA decay mediated by the major-protein-coding determinant of instability
    (mCRD) of the FOS gene in the cytoplasm. Has 3'-5' RNase activity. The CCR4-NOT complex functions as general
    transcription regulation complex (By similarity). In the presence of ZNF335, enhances ligand-dependent transcriptional
    activity of nuclear hormone receptors, including RARA. The increase of ligand-dependent ESR1-mediated transcription is
    much smaller, if any

         Enzyme Numbers (IUBMB): EC 3.1.-.-1 EC 3.1.13.42

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding IEA--
    GO:0004535poly(A)-specific ribonuclease activity TAS--
    GO:0005515protein binding IPI18180299
    GO:0046872metal ion binding IEA--
         
    CNOT6 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for CNOT6 

    miRNA
    Products:            		miRTarBase miRNAs that target CNOT6:
    hsa-mir-373 (MIRT004074), hsa-mir-1 (MIRT003851)

    OriGene 3'-UTR Clone: CNOT6
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CNOT6
    8/84 QIAGEN miScript miRNA Assays for microRNAs that regulate CNOT6 (see all 84):
    hsa-miR-520e hsa-miR-193a-3p hsa-miR-128 hsa-miR-30d hsa-miR-138-2* hsa-miR-371-5p hsa-miR-519a hsa-miR-30a
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CNOT6 (see all 7)
    OriGene shRNA RFP: CNOT6
    Browse OriGene siRNA
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CNOT6
    Sirion Biotech Custom design and validation of potent shRNA sequences against CNOT6 

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for CNOT6
    Sirion Biotech Customized adenovirus for overexpression of CNOT6 
    Sirion Biotech Customized adenovirus for potent knockdown of CNOT6

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CNOT6 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CNOT6
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: CNOT6 (NM_015455)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CNOT6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CNOT6 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for CNOT6
    Search LifeMap BioReagents cell lines for CNOT6
    Sirion Biotech Customized stable knockdown cell line services for CNOT6 
    Sirion Biotech Customized inducible knockdown cell line services for CNOT6
    Sirion Biotech Customized stable overexpressing cell line services for CNOT6
    Sirion Biotech Customized inducible overexpressing cell line services for CNOT6

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CNOT6


    Pathways & Interactions
    for CNOT6 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Deadenylation-dependent mRNA decay
    		Deadenylation-dependent mRNA decay1.00
    		Deadenylation of mRNA0.47
    		RNA degradation0.50
    2Metabolism of mRNA
    		Metabolism of mRNA1.00
    		Metabolism of RNA0.92
    3Generic Transcription Pathway
    		Gene Expression0.46

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    5        Reactome Pathways for CNOT6
        Deadenylation of mRNA
    Deadenylation-dependent mRNA decay
    Metabolism of RNA
    Metabolism of mRNA
    Gene Expression


    1         Kegg Pathway  (Kegg details for CNOT6):
        RNA degradation


    CNOT6 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CNOT6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/127 Interacting proteins for CNOT6 (Q9ULM63 ENSP000002619514) via UniProtKB, MINT, STRING, and/or I2D (see all 127)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CNOT8Q9UFF93, ENSP000002858964I2D: score=8 STRING: ENSP00000285896
    CNOT1A5YKK63, ENSP000003209494STRING: ENSP00000320949 I2D: score=6 
    CNOT3O751753, ENSP000002212324I2D: score=5 STRING: ENSP00000221232
    CNOT2Q9NZN83, ENSP000002291954I2D: score=1 STRING: ENSP00000229195
    FEN1P397483, ENSP000003054804I2D: score=1 STRING: ENSP00000305480
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000288nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay TAS--
    GO:0000289nuclear-transcribed mRNA poly(A) tail shortening TAS--
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--
    GO:0010467gene expression TAS--

    CNOT6 for ontologies           About GeneDecksing



    Drugs & Compounds
    for CNOT6 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for CNOT6 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    C 021 dihydrochloridePotent CCR4 antagonist[864289-85-0]

    1 HMDB Compound for CNOT6    About this table
    CompoundSynonyms CAS #PubMed Ids
    MagnesiumMagnesium (see all 2)7439-95-4--
    Search CenterWatch for drugs/clinical trials and news about CNOT6 

    Transcripts
    for CNOT6 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CNOT6 gene: 
    NM_015455.3  

    Unigene Cluster for CNOT6:

    CCR4-NOT transcription complex, subunit 6
    Hs.608380  [show with all ESTs]
    Unigene Representative Sequence: BC152469
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000510148 ENST00000393356(uc010jld.3) ENST00000507016 ENST00000502447
    ENST00000504343 ENST00000261951(uc003mlx.3 uc010jle.3)

    miRNA
    Products:             		 OriGene 3'-UTR Clone: CNOT6
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CNOT6
    8/84 QIAGEN miScript miRNA Assays for microRNAs that regulate CNOT6 (see all 84):
    hsa-miR-520e hsa-miR-193a-3p hsa-miR-128 hsa-miR-30d hsa-miR-138-2* hsa-miR-371-5p hsa-miR-519a hsa-miR-30a
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CNOT6 (see all 7)
    OriGene shRNA RFP: CNOT6
    Browse OriGene siRNA
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CNOT6
    Sirion Biotech Custom design and validation of potent shRNA sequences against CNOT6 
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CNOT6 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CNOT6
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: CNOT6 (NM_015455)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CNOT6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CNOT6 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CNOT6
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CNOT6
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CNOT6
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CNOT6

    Additional cDNA sequence: 

    AB033020.1 AK023599.1 AK314752.1 AL110144.1 BC015331.1 BC027476.1 BC073142.1 BC090918.1 
    BC114958.1 BC152469.1 

    10 DOTS entries:

    DT.115578  DT.101979531  DT.99934212  DT.100775630  DT.101957004  DT.92435297  DT.92435303  DT.95345830 
    DT.100737457  DT.97799052 

    24/268 AceView cDNA sequences (see all 268):

    CA314233 AA983617 AA884340 CR617731 AW128938 AA603028 AA251375 AI201258 
    AA459219 AA227814 F03677 BG231763 BM678534 BQ029496 CB306950 BU161680 
    AI028199 AW173692 AA115459 CA416373 N90713 AA235905 BQ232180 BM974097 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for CNOT6 (see all 7)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12 ^ 13
    SP1:        -     -     -     -                                               -           -                                             
    SP2:                                                                          -                                                         
    SP3:                                -                                                                                                   
    SP4:                                                                                                                                    
    SP5:                                -                             -     -     -                                                         


    ECgene alternative splicing isoforms for CNOT6

    Expression
    for CNOT6 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CNOT6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TGTCTTCCGT
    CNOT6 Expression
    About this image
    See CNOT6 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CNOT6

    SOURCE GeneReport for Unigene cluster: Hs.608380
        SABiosciences Custom PCR Arrays for CNOT6

    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CNOT6
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CNOT6
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CNOT6
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CNOT6
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CNOT6

    Orthologs
    for CNOT6 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CNOT6 gene from 8/26 species (see all 26)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Cnot61 , 5 CCR4-NOT transcription complex, subunit 61, 5 92.27(n)1
    96.01(a)1    		   11 (29.76 cM)5
    1046251  NM_212484.11  NP_997649.11 
     496715035 
    chicken
    (Gallus gallus)    		 Aves CNOT61 CCR4-NOT transcription complex, subunit 6 86.18(n)
    95.69(a)    		   416293  XM_414612.3  XP_414612.3 
    lizard
    (Anolis carolinensis)    		 Reptilia CNOT66
    		 --
    		 93(a)
    		 1 ↔ 1
    		 2(141011047-141038653)
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.249782 Danio rerio mRNA similar to KIAA1194 (cDNA clone IMAGE5413 more 78.97(n)    BC058309.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta twin1 CG31137-PA 59.3(n)
    59.05(a)    		   42880  NM_170128.1  NP_732964.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea ccr-41 Protein CCR-4 57.1(n)
    51.76(a)    		   178184  NM_001028437.1  NP_001023608.1 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT3G585606
    AT3G585806
    		 carbon catabolite repressor protein 4-like 2
    		 23(a)
    21(a)
    		 many ↔ many
    many ↔ many
    		 3(21650596-21654200)
    3(21660598-21664095)
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    		 endonuclease/exonuclease/phosphatase family domain...
    endonuclease/exonuclease/phosphatase family domain...
    		 22(a)
    21(a)
    		 many ↔ many
    many ↔ many
    		 3(3615603-3621204)
    10(14285713-14291210)


    ENSEMBL Gene Tree for CNOT6 (if available)
    TreeFam Gene Tree for CNOT6 (if available) 

    Paralogs
    for CNOT6 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CNOT6 gene
    ANGEL12  CCRN4L2  PDE122  CNOT6L2  ANGEL22  
    1 SIMAP similar gene for CNOT6 using alignment to 3 protein entries:     CNOT6_HUMAN (see all proteins):
    CNOT6L

    CNOT6 for paralogs           About GeneDecksing



    Genomic Variants
    for CNOT6 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1707 NCBI SNPs in CNOT6 are shown (see all 1707)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 5 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs675592291,2
    		--174650431(+) CCCCCC/TTTTTT 1 -- int11Minor allele frequency- T:0.50CSA 2
    rs346293111,2
    		C--174702887(+) CTGCT-/GTTATTTT 1 -- int11Minor allele frequency- GTT:0.00NA 2
    rs733632191,2
    		C,F--179919427(+) CCGCAC/TAACTC 1 -- us2k11Minor allele frequency- T:0.02WA 118
    rs1411184091,2
    		--179919464(+) GGGATG/TGCCAC 1 -- us2k10--------
    rs567554551,2
    		C--179919468(+) TGGCCA/CCAGGC 1 -- us2k14Minor allele frequency- C:0.13NA WA EA 360
    rs1828402911,2
    		--179919550(+) ATGGCA/GCTAGA 1 -- us2k10--------
    rs1502697971,2
    		--179919589(+) GCAGTA/GCCAAG 1 -- us2k10--------
    rs624054961,2
    		C,F--179919618(+) CGTGCT/CGGGGA 1 -- us2k16Minor allele frequency- C:0.17NA WA EA 364
    rs624054971,2
    		C--179919912(+) ATATAG/CCTCAA 1 -- us2k17Minor allele frequency- C:0.35NA WA EA 366
    rs100728351,2
    		C,F--179919913(+) TATAGC/GTCAAA 1 -- us2k12Minor allele frequency- G:0.08WA NA 238

    HapMap Linkage Disequilibrium report for CNOT6 (179921412 - 180005405 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for CNOT6
         1 CNV: 51654

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CNOT6
    DNA2.0 Custom Variant and Variant Library Synthesis for CNOT6

    Disorders / Diseases
    for CNOT6 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CNOT6 for disorders           About GeneDecksing

    OMIM gene information: 608951    OMIM disorders: --

    4 diseases for CNOT6:    About MalaCards
    food allergy    twinning    malaria    alcoholism

    1 Novoseek disease relationship for CNOT6 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 1 17641067 (1)


    Export disorders for CNOT6 gene to outside databases

    Publications
    for CNOT6 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CNOT6 gene, integrated from 9 sources (see all 38) (see top 10):
    (articles sorted by number of sources associating them with CNOT6)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. CCR4, a 3'-5' poly(A) RNA and ssDNA exonuclease, is the catalytic component of the cytoplasmic deadenylase. (PubMed id 11889047)1, 2, 3 Chen J.... Denis C.L. (2002)
    2. Components of the CCR4-NOT complex function as nuclear hormone receptor coactivators via association with the NRC-interacting Factor NIF-1. (PubMed id 18180299)1, 2, 9 Garapaty S....Samuels H.H. (2008)
    3. UNR, a new partner of poly(A)-binding protein, plays a key role in translationally coupled mRNA turnover mediated by the c-fos major coding-region determinant. (PubMed id 15314026)1, 2, 9 Chang T.-C.... Shyu A.-B. (2004)
    4. Identification of four families of yCCR4- and Mg2+-dependent endonuclease-related proteins in higher eukaryotes, and characterization of orthologs of yCCR4 with a conserved leucine-rich repeat essential for hCAF1/hPOP2 binding. (PubMed id 11747467)1, 2 Dupressoir A....Heidmann T. (2001)
    5. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10574462)1, 2 Nagase T.... Ohara O. (1999)
    6. Isolation and characterization of human orthologs of yeast CCR4-NOT complex subunits. (PubMed id 10637334)1, 9 Albert T.K....Timmers H.T. (2000)
    7. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    8. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    9. The Ccr4a (CNOT6) and Ccr4b (CNOT6L) deadenylase subu nits of the human Ccr4-Not complex contribute to the prevention of cell death a nd senescence. (PubMed id 21233283)1 Mittal S....Winkler G.S. (2011)
    10. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    11. Systematic analysis of human protein complexes identi fies chromosome segregation proteins. (PubMed id 20360068)1 Hutchins J.R....Peters J.M. (2010)
    12. hCCR4/cNOT6 targets DNA-damage response proteins. (PubMed id 18818012)1 Sanchez-Perez I....Perona R. (2009)
    13. Human Ccr4-Not complexes contain variable deadenylase subunits. (PubMed id 19558367)1 Lau N.C....Timmers H.T. (2009)
    14. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
    15. Human TOB, an antiproliferative transcription factor, is a poly(A)-binding protein-dependent positive regulator of cytoplasmic mRNA deadenylation. (PubMed id 17785442)1 Ezzeddine N....Shyu A.B. (2007)
    16. Depletion of mammalian CCR4b deadenylase triggers elevation of the p27Kip1 mRNA level and impairs cell growth. (PubMed id 17452450)1 Morita M....Yamamoto T. (2007)
    17. Transcriptome analysis of human gastric cancer. (PubMed id 16341674)1 Oh J.H....Kim N.S. (2005)
    18. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
    19. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    20. BTG2 antiproliferative protein interacts with the human CCR4 complex existing in vivo in three cell-cycle-regulated forms. (PubMed id 12771185)1 Morel A.-P.... Corbo L. (2003)
    21. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    22. Monitoring cell physiology by expression profiles and discovering cell type-specific genes by compiled expression profiles. (PubMed id 8586417)1 Okubo K....Matsubara K. (1995)
    23. The NOT proteins are part of the CCR4 transcriptional complex and affect gene expression both positively and negatively. (PubMed id 9463387)9 Liu H.Y....Denis C.L. (1998)
    24. Distinct roles for Caf1, Ccr4, Edc3 and CutA in the c o-ordination of transcript deadenylation, decapping and P-body formation in Asp ergillus nidulans. (PubMed id 20233300)9 Morozov I.Y....Caddick M.X. (2010)
    25. CUCU modification of mRNA promotes decapping and tran script degradation in Aspergillus nidulans. (PubMed id 19901075)9 Morozov I.Y....Caddick M.X. (2010)
    26. CCR4-NOT deadenylates mRNA associated with RNA-induce d silencing complexes in human cells. (PubMed id 20065043)9 Piao X....Belasco J.G. (2010)
    27. mRNA degradation by miRNAs and GW182 requires both CCR4:NOT deadenylase and DCP1:DCP2 decapping complexes. (PubMed id 16815998)9 Behm-Ansmant I....Izaurralde E. (2006)
    28. Smaug recruits the CCR4/POP2/NOT deadenylase complex to trigger maternal transcript localization in the early Drosophila embryo. (PubMed id 15723788)9 Semotok J.L....Smibert C.A. (2005)
    29. Dhh1 regulates the G1/S-checkpoint following DNA damage or BRCA1 expression in yeast. (PubMed id 12943812)9 Westmoreland T.J....Bennett C.B. (2003)
    30. Purification and characterization of the 1.0 MDa CCR4-NOT complex identifies two novel components of the complex. (PubMed id 11733989)9 Chen J....Denis C.L. (2001)
    31. Tob2, a novel anti-proliferative Tob/BTG1 family member, associates with a component of the CCR4 transcriptional regulatory complex capable of binding cyclin-dependent kinases. (PubMed id 10602502)9 Ikematsu N.... Yamamoto T. (1999)
    32. Titanium uptake, induction of RANK-L expression, and enhanced proliferation of human T-lymphocytes. (PubMed id 19810098)9 Cadosch D....Filgueira L. (2010)
    33. Yeast screens identify the RNA polymerase II CTD and SPT5 as relevant targets of BRCA1 interaction. (PubMed id 18197258)9 Bennett C.B....Marks J.R. (2008)
    34. Rapid ex vivo isolation and long-term culture of human Th17 cells. (PubMed id 18314131)9 Streeck H....Altfeld M. (2008)
    35. Inhibition of tristetraprolin deadenylation by poly(A) binding protein. (PubMed id 18467502)9 Rowlett R.M....Worthington M.T. (2008)
    36. Increased number of CCR4-positive cells in the duodenum of ovalbumin-induced food allergy model Nc/jic mice and antiallergic activity of fructooligosaccharides. (PubMed id 17384533)9 Fujitani S....Itabashi K. (2007)

    External Searches for CNOT6 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing CNOT6 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 57472 HGNC: 14099 AceView: KIAA1194 Ensembl:ENSG00000113300 euGenes: HUgn57472
    ECgene: CNOT6 Kegg: 57472 H-InvDB: CNOT6

    Other Databases showing CNOT6 gene

    (According to HUGE)
    About This Section
    HUGE: KIAA1194

    Specialized Databases showing CNOT6 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CNOT6 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for CNOT6 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CNOT6 gene:
    Search GeneIP for patents involving CNOT6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for CNOT6 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for CNOT6  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CNOT6   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CNOT6  
     Browse OriGene Protein Over-expression Lysates   Browse OriGene Fluorogenic Cell Assay Kits  
     Browse OriGene siRNAs   OriGene 3'-UTR Clone for CNOT6  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CNOT6   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CNOT6  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CNOT6   OriGene Custom Protein Services for CNOT6  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CNOT6
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CNOT6
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CNOT6
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CNOT6
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CNOT6
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CNOT6
     GenScript Custom Purified and Recombinant Proteins Services for CNOT6 GenScript cDNA clones with any tag delivered in your preferred vector for CNOT6
     GenScript Custom Assay Services for CNOT6 GenScript Custom Superior Antibodies Services for CNOT6
     GenScript Custom overexpressing Cell Line Services for CNOT6 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in CNOT6 promoter
     Search Chromatin IP Primers for CNOT6
     RT2 qPCR Primer Assay in human, mouse, rat CNOT6
     GNC Network for CNOT6
     SABiosciences Custom PCR Arrays for CNOT6
     Tocris compounds for CNOT6
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     CNOT6 antibodies
     CNOT6 proteins
     Antibodies for CNOT6
     See all of Abcam's Antibodies, Kits and Proteins for CNOT6
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     CNOT6 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for CNOT6
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CNOT6
     Browse SwitchGear 3'UTR luciferase reporter plasmids for CNOT6
     SwitchGear Promoter luciferase reporter plasmids for CNOT6
     Search ThermoFisher Antibodies for CNOT6
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CNOT6
     inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for CNOT6
    Sirion Biotech Customized:
     stable knockdown cell line services for CNOT6
     inducible knockdown cell line services for CNOT6
     design and validation of potent shRNA sequences against CNOT6
     adenovirus for potent knockdown of CNOT6
     adenovirus for overexpression of CNOT6
     stable overexpressing cell line services for CNOT6
     inducible overexpressing cell line services for CNOT6
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 14 May 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      CNOT6 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4