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CNOT6 Gene

protein-coding   GIFtS: 61
GCID: GC05P179921

CCR4-NOT Transcription Complex, Subunit 6

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
CCR4-NOT Transcription Complex, Subunit 61 2     KIAA11943 5
CCR42 3 5     Carbon Catabolite Repression 4 Protein2
Carbon Catabolite Repressor Protein 4 Homolog2 3     CCR4-NOT Transcription Complex Subunit 62
Cytoplasmic Deadenylase2 3     CCR4a3
EC 3.1.13.43 8     CCR4 Carbon Catabolite Repression 4-Like3

External Ids:    HGNC: 140991   Entrez Gene: 574722   Ensembl: ENSG000001133007   OMIM: 6089515   UniProtKB: Q9ULM63   
ORGUL members:         

Export aliases for CNOT6 gene to outside databases

Previous GC identifers: GC00U990842 GC05P179855 GC05P179856 GC05P174644


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CNOT6 Gene:
The protein encoded by this gene is a subunit of the CCR4-NOT core transcriptional regulation complex. The encoded
protein has a 3'-5' RNase activity and prefers polyadenylated substates. (provided by RefSeq, Jul 2008)

GeneCards Summary for CNOT6 Gene:
CNOT6 (CCR4-NOT transcription complex, subunit 6) is a protein-coding gene. GO annotations related to this gene include RNA binding and poly(A)-specific ribonuclease activity. An important paralog of this gene is ANGEL1.

UniProtKB/Swiss-Prot: CNOT6_HUMAN, Q9ULM6
Function: Poly(A) nuclease with 3'-5' RNase activity. Catalytic component of the CCR4-NOT complex which is one of
the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation,
miRNA-mediated repression, translational repression during translational initiation and general transcription
regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Involved in
mRNA decay mediated by the major-protein-coding determinant of instability (mCRD) of the FOS gene in the
cytoplasm. In the presence of ZNF335, enhances ligand-dependent transcriptional activity of nuclear hormone
receptors, including RARA. The increase of ligand-dependent ESR1-mediated transcription is much smaller, if any.
Mediates cell proliferation and cell survival and prevents cellular senescence

summary for CNOT6 Gene:
Chemokines (chemotactic cytokines) belong to a family of chemoattractant molecules involved in the directed
migration of immune cells. Over fifty human chemokines have been identified that can be categorised into
four groups; CC, CXC, CX3C and C (XCL1 and XCL2); depending on the spacing of their first two cysteine
residues. Chemokines exert their effects by binding to G-protein-coupled chemokine receptors on the surface
of cells, predominantly leukocytes. Eighteen human chemokine receptors have been identified that are
classified according to the class of chemokines that they bind. The major function of chemokines is to
regulate leukocyte trafficking in hematopoiesis and in innate and adaptive immunity. Other functions include
angiogenic activity, apoptosis, T-cell differentiation and phagocyte activation. Inadvertent activation of
chemokine receptors leads to autoimmunity by inappropriately targeting self antigens for destruction by
cytotoxic T-cells and macrophages.

Gene Wiki entry for CNOT6 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NT_023133.14  NC_018916.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CNOT6 gene promoter:
         AP-2rep   FOXF2   AP-4   E47   RORalpha1   FOXJ2 (long isoform)   Hand1   FOXO1a   FOXJ2   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCNOT6 promoter sequence
   Search Chromatin IP Primers for CNOT6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CNOT6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q35.3   Ensembl cytogenetic band:  5q35.3   HGNC cytogenetic band: 5q35.3

CNOT6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CNOT6 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P179921:  view genomic region     (about GC identifiers)

Start:
179,921,412 bp from pter      End:
180,005,405 bp from pter
Size:
83,994 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CNOT6_HUMAN, Q9ULM6 (See protein sequence)
Recommended Name: CCR4-NOT transcription complex subunit 6  
Size: 557 amino acids; 63307 Da
Cofactor: Magnesium
Subunit: Component of the CCR4-NOT complex; distinct complexes seem to exist that differ in the participation of
probably mutually exclusive catalytic subunits; the complex contains two deadenylase subunits, CNOT6 or CNOT6L,
and CNOT7 or CNOT8. Interacts with UNR and ZNF335
Secondary accessions: A7MD46 D3DWR0

Explore the universe of human proteins at neXtProt for CNOT6: NX_Q9ULM6

Explore proteomics data for CNOT6 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys128
  • Modification sites at PhosphoSitePlus
  • 2 DME Specific Peptides for CNOT6 (Q9ULM6)
     PKSRARTM  NRVMTKDNI 


    See CNOT6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_056270.2  
    ENSEMBL proteins: 
     ENSP00000377024   ENSP00000422087   ENSP00000261951  
    Reactome Protein details: Q9ULM6

    CNOT6 Human Recombinant Protein Products:

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    Novus Biologicals CNOT6 Proteins
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for CNOT6

     
    Search eBioscience for Proteins for CNOT6 

    CNOT6 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Abcam antibodies for CNOT6
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    LSBio Antibodies in human, mouse, rat for CNOT6

    CNOT6 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Search eBioscience for ELISAs for CNOT6 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR001611 Leu-rich_rpt
     IPR003591 Leu-rich_rpt_typical-subtyp
     IPR005135 Endo/exonuclease/phosphatase

    Graphical View of Domain Structure for InterPro Entry Q9ULM6

    ProtoNet protein and cluster: Q9ULM6

    UniProtKB/Swiss-Prot: CNOT6_HUMAN, Q9ULM6
    Similarity: Belongs to the CCR4/nocturin family
    Similarity: Contains 4 LRR (leucine-rich) repeats


    Find genes that share domains with CNOT6           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CNOT6_HUMAN, Q9ULM6
    Function: Poly(A) nuclease with 3'-5' RNase activity. Catalytic component of the CCR4-NOT complex which is one of
    the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation,
    miRNA-mediated repression, translational repression during translational initiation and general transcription
    regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Involved in
    mRNA decay mediated by the major-protein-coding determinant of instability (mCRD) of the FOS gene in the
    cytoplasm. In the presence of ZNF335, enhances ligand-dependent transcriptional activity of nuclear hormone
    receptors, including RARA. The increase of ligand-dependent ESR1-mediated transcription is much smaller, if any.
    Mediates cell proliferation and cell survival and prevents cellular senescence
    Catalytic activity: Exonucleolytic cleavage of poly(A) to 5'-AMP

         Enzyme Number (IUBMB): EC 3.1.13.41 2

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding IEA--
    GO:0004532exoribonuclease activity IDA11889047
    GO:0004535poly(A)-specific ribonuclease activity TAS--
    GO:0005515protein binding IPI11747467
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with CNOT6           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CNOT6
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CNOT6

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CNOT6
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CNOT6

    miRNA
    Products:
        
    miRTarBase miRNAs that target CNOT6:
    hsa-mir-96-5p (MIRT027912), hsa-mir-130b-3p (MIRT020329), hsa-mir-769-5p (MIRT039160), hsa-mir-193b-3p (MIRT016605), hsa-mir-1 (MIRT003851), hsa-mir-106b-5p (MIRT044283), hsa-mir-15a-3p (MIRT038987), hsa-mir-183-5p (MIRT047042), hsa-mir-373-3p (MIRT004074), hsa-mir-9-5p (MIRT021485), hsa-mir-19b-3p (MIRT031275)

    Block miRNA regulation of human, mouse, rat CNOT6 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CNOT6 (see all 84):
    hsa-miR-520e hsa-miR-193a-3p hsa-miR-128 hsa-miR-30d hsa-miR-138-2* hsa-miR-371-5p hsa-miR-519a hsa-miR-30a
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CNOT6

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: CNOT6 (NM_015455)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CNOT6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CNOT6
    Addgene plasmids for CNOT6 

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CNOT6


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CNOT6_HUMAN, Q9ULM6: Cytoplasm (Probable). Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus4

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005829cytosol TAS--
    GO:0030014CCR4-NOT complex IDA19558367

    Find genes that share ontologies with CNOT6           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CNOT6 About    
    See pathways by source

    SuperPathContained pathways About
    1Deadenylation-dependent mRNA decay
    Deadenylation-dependent mRNA decay0.48
    Deadenylation of mRNA0.48
    RNA degradation0.48
    2Gene Expression
    Gene Expression0.40


    Find genes that share SuperPaths with CNOT6           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CNOT6 (see all 8)
        Chemokine Signaling
    STAT3 Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    Tec Kinases Signaling

    1 Reactome Pathway for CNOT6
        Deadenylation of mRNA


    1 Kegg Pathway  (Kegg details for CNOT6):
        RNA degradation

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CNOT6
    Interactions:

        GeneGlobe Interaction Network for CNOT6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CNOT6 (Q9ULM61, 3 ENSP000002619514) via UniProtKB, MINT, STRING, and/or I2D (see all 203)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000206286Q8N1B43I2D: score=1 
    ENSG00000224455Q8N1B43I2D: score=1 
    ENSG00000225590Q8N1B43I2D: score=1 
    ENSG00000228425Q8N1B43I2D: score=1 
    ENSG00000236014Q8N1B43I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000288nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay TAS--
    GO:0000289nuclear-transcribed mRNA poly(A) tail shortening TAS--
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--
    GO:0006417regulation of translation IEA--

    Find genes that share ontologies with CNOT6           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for CNOT6 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    RS 504393Highly selective CCR2 chemokine receptor antagonist[300816-15-3]
    MaravirocSelective CCR5 antagonist[376348-65-1]
    SB 225002Potent and selective CXCR2 antagonist[182498-32-4]
    SB 265610Potent CXCR2 antagonist[211096-49-0]
    TC 14012CXCR4 antagonist; CXCR7 agonist[368874-34-4]

    1 HMDB Compound for CNOT6    About this table
    CompoundSynonyms CAS #PubMed Ids
    MagnesiumMagnesium (see all 2)7439-95-4--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CNOT6 gene: 
    NM_015455.3  

    Unigene Cluster for CNOT6:

    CCR4-NOT transcription complex, subunit 6
    Hs.608380  [show with all ESTs]
    Unigene Representative Sequence: BC152469
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000510148 ENST00000393356(uc010jld.3) ENST00000507016 ENST00000502447
    ENST00000504343 ENST00000261951(uc003mlx.3 uc010jle.3)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CNOT6 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CNOT6 (see all 84):
    hsa-miR-520e hsa-miR-193a-3p hsa-miR-128 hsa-miR-30d hsa-miR-138-2* hsa-miR-371-5p hsa-miR-519a hsa-miR-30a
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CNOT6
    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CNOT6 (NM_015455)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CNOT6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CNOT6
    Addgene plasmids for CNOT6 
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for CNOT6
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CNOT6
      QuantiTect SYBR Green Assays in human, mouse, rat CNOT6
      QuantiFast Probe-based Assays in human, mouse, rat CNOT6

    Additional mRNA sequence: 

    AB033020.1 AK023599.1 AK314752.1 AL110144.1 BC015331.1 BC027476.1 BC073142.1 BC090918.1 
    BC114958.1 BC152469.1 

    10 DOTS entries:

    DT.115578  DT.101979531  DT.99934212  DT.100775630  DT.101957004  DT.92435297  DT.92435303  DT.95345830 
    DT.100737457  DT.97799052 

    Selected AceView cDNA sequences (see all 268):

    AI028199 AA361774 BM974097 AA235905 AW173692 AA227943 AI276566 AI005662 
    BM682186 BP379655 CB959839 AA971246 AA227814 CB306950 BF940524 BG231763 
    AA630737 AA983617 Z41386 AA251375 BU167426 AI810439 NM_015455 BE897352 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CNOT6 (see all 7)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12 ^ 13
    SP1:        -     -     -     -                                               -           -                                             
    SP2:                                                                          -                                                         
    SP3:                                -                                                                                                   
    SP4:                                                                                                                                    
    SP5:                                -                             -     -     -                                                         


    ECgene alternative splicing isoforms for CNOT6

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    CNOT6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTCTTCCGT
    CNOT6 Expression
    About this image


    CNOT6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Brain (Nervous System)    fully expand to see all 6 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Eye (Sensory Organs)
             Lens
    CNOT6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CNOT6 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.608380
        Custom PCR Arrays for CNOT6
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for CNOT6
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CNOT6
    QuantiTect SYBR Green Assays in human, mouse, rat CNOT6
    QuantiFast Probe-based Assays in human, mouse, rat CNOT6
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CNOT6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for CNOT6 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cnot61 , 5 CCR4-NOT transcription complex, subunit 61, 5 92.27(n)1
    96.01(a)1
      11 (29.76 cM)5
    1046251  NM_212484.11  NP_997649.11 
     496715035 
    chicken
    (Gallus gallus)
    Aves CNOT61 CCR4-NOT transcription complex, subunit 6 86.18(n)
    95.69(a)
      416293  XM_414612.4  XP_414612.3 
    lizard
    (Anolis carolinensis)
    Reptilia CNOT66
    CCR4-NOT transcription complex, subunit 6
    93(a)
    1 ↔ 1
    2(141011047-141051754)
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.249782 Danio rerio mRNA similar to KIAA1194 (cDNA clone IMAGE5413 more 78.97(n)    BC058309.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta twin6
    twin
    56(a)
    1 → many
    3R(20022615-20047687)
    worm
    (Caenorhabditis elegans)
    Secernentea ccr-46
    Protein CCR-4, isoform a
    31(a)
    1 → many
    IV(12361570-12371828) WBGene00000376
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CCR4(YAL021C)4 Component of the CCR4-NOT transcriptional complex, more   --   1(113359-110846) 851212  NP_009381.1 


    ENSEMBL Gene Tree for CNOT6 (if available)
    TreeFam Gene Tree for CNOT6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CNOT6 gene
    ANGEL12  CCRN4L2  PDE122  ANGEL22  CNOT6L2  
    1 SIMAP similar gene for CNOT6 using alignment to 3 protein entries:     CNOT6_HUMAN (see all proteins):
    CNOT6L

    Find genes that share paralogs with CNOT6           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CNOT6 (see all 1968)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs733632191,2
    C,F--179919427(+) CCGCAC/TAACTC 1 -- us2k11Minor allele frequency- T:0.02WA 118
    rs1411184091,2
    C--179919464(+) GGGATG/TGCCAC 1 -- us2k10--------
    rs567554551,2
    C--179919468(+) TGGCCA/CCAGGC 1 -- us2k14Minor allele frequency- C:0.13NA WA EA 360
    rs1828402911,2
    --179919550(+) ATGGCA/GCTAGA 1 -- us2k10--------
    rs1502697971,2
    C--179919589(+) GCAGTA/GCCAAG 1 -- us2k10--------
    rs624054961,2
    C,F--179919618(+) CGTGCT/CGGGGA 1 -- us2k16Minor allele frequency- C:0.17NA WA EA 364
    rs624054971,2
    C--179919912(+) ATATAG/CCTCAA 1 -- us2k17Minor allele frequency- C:0.35NA WA EA 366
    rs100728351,2
    C,F--179919913(+) TATAGC/GTCAAA 1 -- us2k12Minor allele frequency- G:0.08WA NA 238
    rs728111271,2
    C--179919918(+) CTCAAT/ATTTTT 1 -- us2k11Minor allele frequency- A:0.00NA 2
    rs715770441,2
    C--179919924(+) TTTTT-/C/C   
       TT
    /TT
    TTTTT
    2 -- us2k1 cds11NA 2

    HapMap Linkage Disequilibrium report for CNOT6 (179921412 - 180005405 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for CNOT6 (see all 11):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv998085CNV Deletion20482838
    esv991928CNV Deletion20482838
    esv2731343CNV Deletion23290073
    esv2731344CNV Deletion23290073
    esv1078210CNV Deletion17803354
    esv1787252CNV Deletion17803354
    nsv509111CNV Insertion20534489
    nsv509110CNV Insertion20534489
    nsv519380CNV Loss19592680
    nsv823366CNV Loss20364138

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CNOT6
    DNA2.0 Custom Variant and Variant Library Synthesis for CNOT6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608951    OMIM disorders: --


    Find genes that share disorders with CNOT6           About GenesLikeMe

    1 Novoseek inferred disease relationship for CNOT6 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 1 17641067 (1)

    Genetic Association Database (GAD): CNOT6

    Export disorders for CNOT6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CNOT6 gene, integrated from 10 sources (see all 41) (see top 10):
    (articles sorted by number of sources associating them with CNOT6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. CCR4, a 3'-5' poly(A) RNA and ssDNA exonuclease, is the catalytic component of the cytoplasmic deadenylase. (PubMed id 11889047)1, 2, 3 Chen J.... Denis C.L. (EMBO J. 2002)
    2. Components of the CCR4-NOT complex function as nuclear hormone receptor coactivators via association with the NRC-interacting Factor NIF-1. (PubMed id 18180299)1, 2, 9 Garapaty S.... Samuels H.H. (J. Biol. Chem. 2008)
    3. UNR, a new partner of poly(A)-binding protein, plays a key role in translationally coupled mRNA turnover mediated by the c-fos major coding-region determinant. (PubMed id 15314026)1, 2, 9 Chang T.-C.... Shyu A.-B. (Genes Dev. 2004)
    4. The Ccr4a (CNOT6) and Ccr4b (CNOT6L) deadenylase subunits of the human Ccr4-Not complex contribute to the prevention of cell death and senescence. (PubMed id 21233283)1, 2 Mittal S.... Winkler G.S. (Mol. Biol. Cell 2011)
    5. Human Ccr4-Not complexes contain variable deadenylase subunits. (PubMed id 19558367)1, 2 Lau N.C.... Timmers H.T. (Biochem. J. 2009)
    6. Identification of four families of yCCR4- and Mg2+-dependent endonuclease-related proteins in higher eukaryotes, and characterization of orthologs of yCCR4 with a conserved leucine-rich repeat essential for hCAF1/hPOP2 binding. (PubMed id 11747467)1, 2 Dupressoir A....Heidmann T. (BMC Genomics 2001)
    7. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10574462)1, 2 Nagase T.... Ohara O. (DNA Res. 1999)
    8. CCR4-NOT deadenylates mRNA associated with complexes in human cells. (PubMed id 20065043)2, 9 Piao X.... Belasco J.G. (Mol. Cell. Biol. 2010)
    9. Isolation and characterization of human orthologs of yeast CCR4-NOT complex subunits. (PubMed id 10637334)1, 9 Albert T.K....Timmers H.T.M. (Nucleic Acids Res. 2000)
    10. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    11. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    12. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    13. A proteomic investigation of ligand-dependent HSP90 complexes reveals CHORDC1 as a novel ADP-dependent HSP90-interacting protein. (PubMed id 19875381)1 Gano J.J. and Simon J.A. (Mol. Cell. Proteomics 2010)
    14. Systematic analysis of human protein complexes identifies chromosome segregation proteins. (PubMed id 20360068)1 Hutchins J.R.... Peters J.M. (Science 2010)
    15. hCCR4/cNOT6 targets DNA-damage response proteins. (PubMed id 18818012)1 Sanchez-Perez I....Perona R. (Cancer Lett. 2009)
    16. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (EMBO J. 2009)
    17. Mammalian miRNA RISC recruits CAF1 and PABP to affect PABP-dependent deadenylation. (PubMed id 19716330)1 Fabian M.R.... Sonenberg N. (Mol. Cell 2009)
    18. Human TOB, an antiproliferative transcription factor, is a poly(A)-binding protein-dependent positive regulator of cytoplasmic mRNA deadenylation. (PubMed id 17785442)1 Ezzeddine N....Shyu A.B. (Mol. Cell. Biol. 2007)
    19. Depletion of mammalian CCR4b deadenylase triggers elevation of the p27Kip1 mRNA level and impairs cell growth. (PubMed id 17452450)1 Morita M....Yamamoto T. (Mol. Cell. Biol. 2007)
    20. Genome-wide association with bone mass and geometry in the Framingham Heart Study. (PubMed id 17903296)4 Kiel D.P....Karasik D. (BMC Med. Genet. 2007)
    21. Transcriptome analysis of human gastric cancer. (PubMed id 16341674)1 Oh J.H.... Kim N.S. (Mamm. Genome 2005)
    22. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)
    23. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    24. BTG2 antiproliferative protein interacts with the human CCR4 complex existing in vivo in three cell-cycle-regulated forms. (PubMed id 12771185)1 Morel A.-P.... Corbo L. (J. Cell Sci. 2003)
    25. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    26. Monitoring cell physiology by expression profiles and discovering cell type-specific genes by compiled expression profiles. (PubMed id 8586417)1 Okubo K....Matsubara K. (Genomics 1995)
    27. The NOT proteins are part of the CCR4 transcriptional complex and affect gene expression both positively and negatively. (PubMed id 9463387)9 Liu H.Y....Denis C.L. (EMBO J. 1998)
    28. Distinct roles for Caf1, Ccr4, Edc3 and CutA in the co-ordination of transcript deadenylation, decapping and P-body formation in Aspergillus nidulans. (PubMed id 20233300)9 Morozov I.Y....Caddick M.X. (Mol. Microbiol. 2010)
    29. CUCU modification of mRNA promotes decapping and transcript degradation in Aspergillus nidulans. (PubMed id 19901075)9 Morozov I.Y....Caddick M.X. (Mol. Cell. Biol. 2010)
    30. mRNA degradation by miRNAs and GW182 requires both CCR4:NOT deadenylase and DCP1:DCP2 decapping complexes. (PubMed id 16815998)9 Behm-Ansmant I....Izaurralde E. (amp 2006)
    31. Smaug recruits the CCR4/POP2/NOT deadenylase complex to trigger maternal transcript localization in the early Drosophila embryo. (PubMed id 15723788)9 Semotok J.L....Smibert C.A. (Curr. Biol. 2005)
    32. Dhh1 regulates the G1/S-checkpoint following DNA damage or BRCA1 expression in yeast. (PubMed id 12943812)9 Westmoreland T.J....Bennett C.B. (J. Surg. Res. 2003)
    33. Purification and characterization of the 1.0 MDa CCR4-NOT complex identifies two novel components of the complex. (PubMed id 11733989)9 Chen J....Denis C.L. (J. Mol. Biol. 2001)
    34. Tob2, a novel anti-proliferative Tob/BTG1 family member, associates with a component of the CCR4 transcriptional regulatory complex capable of binding cyclin-dependent kinases. (PubMed id 10602502)9 Ikematsu N.... Yamamoto T. (Oncogene 1999)
    35. Titanium uptake, induction of RANK-L expression, and enhanced proliferation of human T-lymphocytes. (PubMed id 19810098)9 Cadosch D....Filgueira L. (J. Orthop. Res. 2010)
    36. Yeast screens identify the RNA polymerase II CTD and SPT5 as relevant targets of BRCA1 interaction. (PubMed id 18197258)9 Bennett C.B....Marks J.R. (PLoS ONE 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 57472 HGNC: 14099 AceView: KIAA1194 Ensembl:ENSG00000113300 euGenes: HUgn57472
    ECgene: CNOT6 Kegg: 57472 H-InvDB: CNOT6

    (According to HUGE)
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    HUGE: KIAA1194

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CNOT6 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CNOT6 gene:
    Search GeneIP for patents involving CNOT6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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