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Aliases for CNOT6 Gene

Aliases for CNOT6 Gene

  • CCR4-NOT Transcription Complex Subunit 6 2 3 5
  • Carbon Catabolite Repressor Protein 4 Homolog 3 4
  • CCR4-NOT Transcription Complex, Subunit 6 2 3
  • Cytoplasmic Deadenylase 3 4
  • EC 3.1.13.4 4 63
  • Ccr4a 3 4
  • CCR4 3 4
  • CCR4 Carbon Catabolite Repression 4-Like 4
  • Carbon Catabolite Repression 4 Protein 3
  • KIAA1194 4

External Ids for CNOT6 Gene

Previous GeneCards Identifiers for CNOT6 Gene

  • GC00U990842
  • GC05P179855
  • GC05P179856
  • GC05P179921
  • GC05P174644

Summaries for CNOT6 Gene

Entrez Gene Summary for CNOT6 Gene

  • This gene encodes the catalytic component of the CCR4-NOT core transcriptional regulation complex. The encoded protein has a 3'-5' RNase activity and prefers polyadenylated substrates. The CCR4-NOT complex plays a role in many cellular processes, including miRNA-mediated repression, mRNA degradation, and transcriptional regulation. [provided by RefSeq, Dec 2014]

GeneCards Summary for CNOT6 Gene

CNOT6 (CCR4-NOT Transcription Complex Subunit 6) is a Protein Coding gene. Among its related pathways are Gene Expression and Signaling by GPCR. GO annotations related to this gene include RNA binding and poly(A)-specific ribonuclease activity. An important paralog of this gene is PDE12.

UniProtKB/Swiss-Prot for CNOT6 Gene

  • Poly(A) nuclease with 3-5 RNase activity. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Involved in mRNA decay mediated by the major-protein-coding determinant of instability (mCRD) of the FOS gene in the cytoplasm. In the presence of ZNF335, enhances ligand-dependent transcriptional activity of nuclear hormone receptors, including RARA. The increase of ligand-dependent ESR1-mediated transcription is much smaller, if any. Mediates cell proliferation and cell survival and prevents cellular senescence.

Gene Wiki entry for CNOT6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CNOT6 Gene

Genomics for CNOT6 Gene

Regulatory Elements for CNOT6 Gene

Promoters for CNOT6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CNOT6 on UCSC Golden Path with GeneCards custom track

Genomic Location for CNOT6 Gene

Chromosome:
5
Start:
180,494,373 bp from pter
End:
180,578,405 bp from pter
Size:
84,033 bases
Orientation:
Plus strand

Genomic View for CNOT6 Gene

Genes around CNOT6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CNOT6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CNOT6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CNOT6 Gene

Proteins for CNOT6 Gene

  • Protein details for CNOT6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9ULM6-CNOT6_HUMAN
    Recommended name:
    CCR4-NOT transcription complex subunit 6
    Protein Accession:
    Q9ULM6
    Secondary Accessions:
    • A7MD46
    • D3DWR0

    Protein attributes for CNOT6 Gene

    Size:
    557 amino acids
    Molecular mass:
    63307 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Component of the CCR4-NOT complex; distinct complexes seem to exist that differ in the participation of probably mutually exclusive catalytic subunits; the complex contains two deadenylase subunits, CNOT6 or CNOT6L, and CNOT7 or CNOT8. Interacts with UNR and ZNF335.

neXtProt entry for CNOT6 Gene

Proteomics data for CNOT6 Gene at MOPED

Selected DME Specific Peptides for CNOT6 Gene

Post-translational modifications for CNOT6 Gene

  • Ubiquitination at Lys 128
  • Modification sites at PhosphoSitePlus

Other Protein References for CNOT6 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CNOT6 (CNOT6)

Domains & Families for CNOT6 Gene

Gene Families for CNOT6 Gene

Protein Domains for CNOT6 Gene

Suggested Antigen Peptide Sequences for CNOT6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9ULM6

UniProtKB/Swiss-Prot:

CNOT6_HUMAN :
  • Belongs to the CCR4/nocturin family.
  • Contains 4 LRR (leucine-rich) repeats.
Family:
  • Belongs to the CCR4/nocturin family.
Similarity:
  • Contains 4 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with CNOT6: view

Function for CNOT6 Gene

Molecular function for CNOT6 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Exonucleolytic cleavage of poly(A) to 5-AMP.
UniProtKB/Swiss-Prot Function:
Poly(A) nuclease with 3-5 RNase activity. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Involved in mRNA decay mediated by the major-protein-coding determinant of instability (mCRD) of the FOS gene in the cytoplasm. In the presence of ZNF335, enhances ligand-dependent transcriptional activity of nuclear hormone receptors, including RARA. The increase of ligand-dependent ESR1-mediated transcription is much smaller, if any. Mediates cell proliferation and cell survival and prevents cellular senescence.

Enzyme Numbers (IUBMB) for CNOT6 Gene

Gene Ontology (GO) - Molecular Function for CNOT6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004532 exoribonuclease activity IDA 11889047
genes like me logo Genes that share ontologies with CNOT6: view
genes like me logo Genes that share phenotypes with CNOT6: view

Animal Models for CNOT6 Gene

MGI Knock Outs for CNOT6:

Animal Model Products

  • Taconic Biosciences Mouse Models for CNOT6

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CNOT6 Gene

Localization for CNOT6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CNOT6 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CNOT6 Gene COMPARTMENTS Subcellular localization image for CNOT6 gene
Compartment Confidence
cytosol 5
nucleus 4

Gene Ontology (GO) - Cellular Components for CNOT6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with CNOT6: view

Pathways & Interactions for CNOT6 Gene

genes like me logo Genes that share pathways with CNOT6: view

Gene Ontology (GO) - Biological Process for CNOT6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0010467 gene expression TAS --
GO:0010606 positive regulation of cytoplasmic mRNA processing body assembly IMP 21233283
GO:0035195 gene silencing by miRNA TAS 20065043
GO:0043928 exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay IDA 20065043
genes like me logo Genes that share ontologies with CNOT6: view

No data available for SIGNOR curated interactions for CNOT6 Gene

Drugs & Compounds for CNOT6 Gene

(1) Drugs for CNOT6 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Magnesium Nutra 0
genes like me logo Genes that share compounds with CNOT6: view

Transcripts for CNOT6 Gene

Unigene Clusters for CNOT6 Gene

CCR4-NOT transcription complex, subunit 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CNOT6 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12 ^ 13
SP1: - - - - - -
SP2: -
SP3: -
SP4:
SP5: - - - -
SP6:
SP7: - - -

Relevant External Links for CNOT6 Gene

GeneLoc Exon Structure for
CNOT6
ECgene alternative splicing isoforms for
CNOT6

Expression for CNOT6 Gene

mRNA expression in normal human tissues for CNOT6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CNOT6 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CNOT6 Gene



SOURCE GeneReport for Unigene cluster for CNOT6 Gene Hs.608380

genes like me logo Genes that share expression patterns with CNOT6: view

Protein tissue co-expression partners for CNOT6 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CNOT6 Gene

Orthologs for CNOT6 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CNOT6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CNOT6 35
  • 99.7 (n)
  • 100 (a)
CNOT6 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CNOT6 36
  • 97 (a)
OneToOne
CNOT6 35
  • 93.48 (n)
  • 97.49 (a)
dog
(Canis familiaris)
Mammalia CNOT6 35
  • 94.02 (n)
  • 98.03 (a)
CNOT6 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cnot6 16
Cnot6 35
  • 92.27 (n)
  • 96.01 (a)
Cnot6 36
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CNOT6 36
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CNOT6 36
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cnot6 35
  • 92.76 (n)
  • 96.23 (a)
chicken
(Gallus gallus)
Aves CNOT6 36
  • 96 (a)
OneToOne
CNOT6 35
  • 86.18 (n)
  • 95.69 (a)
lizard
(Anolis carolinensis)
Reptilia CNOT6 36
  • 93 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii cnot6 36
  • 86 (a)
OneToMany
CNOT6 (2 of 2) 36
  • 84 (a)
OneToMany
cnot6 35
  • 75.06 (n)
  • 86.15 (a)
Dr.24978 35
fruit fly
(Drosophila melanogaster)
Insecta twin 36
  • 56 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ccr-4 36
  • 31 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CCR4 36
  • 21 (a)
OneToMany
CCR4 38
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 37 (a)
OneToMany
Species with no ortholog for CNOT6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for CNOT6 Gene

ENSEMBL:
Gene Tree for CNOT6 (if available)
TreeFam:
Gene Tree for CNOT6 (if available)

Paralogs for CNOT6 Gene

Paralogs for CNOT6 Gene

(1) SIMAP similar genes for CNOT6 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CNOT6: view

Variants for CNOT6 Gene

Sequence variations from dbSNP and Humsavar for CNOT6 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs15804 -- 180,577,829(-) AGCCC(C/T)TGTTA utr-variant-3-prime
rs780123 -- 180,543,765(-) CGATA(C/G)CAAAA intron-variant
rs780124 -- 180,517,310(+) TTTTA(A/G)TACAG intron-variant
rs780128 -- 180,531,241(-) ctgcc(C/T)ggcag intron-variant
rs780129 -- 180,530,716(-) cggaa(A/G)gccgc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CNOT6 Gene

Variant ID Type Subtype PubMed ID
nsv509110 CNV Insertion 20534489
nsv830564 CNV Gain 17160897
esv2731343 CNV Deletion 23290073
nsv519380 CNV Loss 19592680
esv1078210 CNV Deletion 17803354
esv2731344 CNV Deletion 23290073
esv991928 CNV Deletion 20482838
esv998085 CNV Deletion 20482838
esv1787252 CNV Deletion 17803354
nsv823366 CNV Loss 20364138
nsv509111 CNV Insertion 20534489

Variation tolerance for CNOT6 Gene

Residual Variation Intolerance Score: 23.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.43; 28.12% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CNOT6 Gene

HapMap Linkage Disequilibrium report
CNOT6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CNOT6 Gene

Disorders for CNOT6 Gene

Relevant External Links for CNOT6

Genetic Association Database (GAD)
CNOT6
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CNOT6

No disorders were found for CNOT6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CNOT6 Gene

Publications for CNOT6 Gene

  1. CCR4, a 3'-5' poly(A) RNA and ssDNA exonuclease, is the catalytic component of the cytoplasmic deadenylase. (PMID: 11889047) Chen J. … Denis C.L. (EMBO J. 2002) 2 3 4 67
  2. CCR4-NOT deadenylates mRNA associated with complexes in human cells. (PMID: 20065043) Piao X. … Belasco J.G. (Mol. Cell. Biol. 2010) 3 23
  3. Components of the CCR4-NOT complex function as nuclear hormone receptor coactivators via association with the NRC-interacting Factor NIF-1. (PMID: 18180299) Garapaty S. … Samuels H.H. (J. Biol. Chem. 2008) 3 23
  4. UNR, a new partner of poly(A)-binding protein, plays a key role in translationally coupled mRNA turnover mediated by the c-fos major coding-region determinant. (PMID: 15314026) Chang T.-C. … Shyu A.-B. (Genes Dev. 2004) 3 23
  5. Isolation and characterization of human orthologs of yeast CCR4-NOT complex subunits. (PMID: 10637334) Albert T.K. … Timmers H.T.M. (Nucleic Acids Res. 2000) 3 23

Products for CNOT6 Gene

Sources for CNOT6 Gene

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