Aliases for CNOT6 Gene
Aliases for CNOT6 Gene
External Ids for CNOT6 Gene
- HGNC: 14099
- Entrez Gene: 57472
- Ensembl: ENSG00000113300
- OMIM: 608951
- UniProtKB: Q9ULM6
Previous GeneCards Identifiers for CNOT6 Gene
- GC00U990842
- GC05P179855
- GC05P179856
- GC05P179921
- GC05P174644
Summaries for CNOT6 Gene
-
This gene encodes the catalytic component of the CCR4-NOT core transcriptional regulation complex. The encoded protein has a 3'-5' RNase activity and prefers polyadenylated substrates. The CCR4-NOT complex plays a role in many cellular processes, including miRNA-mediated repression, mRNA degradation, and transcriptional regulation. [provided by RefSeq, Dec 2014]
GeneCards Summary for CNOT6 Gene
CNOT6 (CCR4-NOT Transcription Complex Subunit 6) is a Protein Coding gene. Among its related pathways are Gene Expression and Deadenylation-dependent mRNA decay. Gene Ontology (GO) annotations related to this gene include RNA binding and poly(A)-specific ribonuclease activity. An important paralog of this gene is CNOT6L.
UniProtKB/Swiss-Prot for CNOT6 Gene
-
Poly(A) nuclease with 3-5 RNase activity. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Involved in mRNA decay mediated by the major-protein-coding determinant of instability (mCRD) of the FOS gene in the cytoplasm. In the presence of ZNF335, enhances ligand-dependent transcriptional activity of nuclear hormone receptors, including RARA. The increase of ligand-dependent ESR1-mediated transcription is much smaller, if any. Mediates cell proliferation and cell survival and prevents cellular senescence.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CNOT6 Gene
Genomics for CNOT6 Gene
GeneHancer (GH) Regulatory Elements for CNOT6 Gene
Promoters and enhancers for CNOT6 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around CNOT6 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for CNOT6 Gene
Genomic Locations for CNOT6 Gene
- chr5:180,494,373-180,578,405
- (GRCh38/hg38)
- Size:
- 84,033 bases
- Orientation:
- Plus strand
- chr5:179,921,412-180,005,405
- (GRCh37/hg19)
Genomic View for CNOT6 Gene
Genes around CNOT6 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 5q35.3 by Ensembl
- 5q35.3 by Entrez Gene
- 5q35.3 by HGNC
CNOT6 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CNOT6 Gene
Proteins for CNOT6 Gene
-
Protein details for CNOT6 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9ULM6-CNOT6_HUMAN
- Recommended name:
- CCR4-NOT transcription complex subunit 6
- Protein Accession:
- Q9ULM6
- A7MD46
- D3DWR0
Protein attributes for CNOT6 Gene
- Size:
- 557 amino acids
- Molecular mass:
- 63307 Da
- Cofactor:
- Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
- Quaternary structure:
-
- Component of the CCR4-NOT complex; distinct complexes seem to exist that differ in the participation of probably mutually exclusive catalytic subunits; the complex contains two deadenylase subunits, CNOT6 or CNOT6L, and CNOT7 or CNOT8 (PubMed:19558367). Interacts with CNOT7 and CNOT8 (PubMed:11747467). Interacts with UNR (PubMed:15314026). Interacts with ZFP36L1 (via N-terminus) (PubMed:15687258). Interacts with ZNF335 (PubMed:18180299).
Protein Expression for CNOT6 Gene
Selected DME Specific Peptides for CNOT6 Gene
- Q9ULM6:
-
- NRVMTKDNI
- PKSRARTM
Post-translational modifications for CNOT6 Gene
- Ubiquitination at Lys128
Other Protein References for CNOT6 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Cell Signaling Technology (CST) Antibodies for CNOT6 (CNOT6)
-
Custom Antibody ServicesOriGene Antibodies for CNOT6
- Novus Biologicals Antibodies for CNOT6
-
Abcam antibodies for CNOT6
- Invitrogen Antibodies for CNOT6
- GeneTex CNOT6 antibody for CNOT6
-
Santa Cruz Biotechnology (SCBT) Antibodies for CNOT6
- Sino Biological Antibodies for CNOT6
Protein Products
-
OriGene Purified Proteins for CNOT6
- Search Origene for MassSpec and Protein Over-expression Lysates for CNOT6
- Origene Custom Protein Services for CNOT6
- Novus Biologicals proteins for CNOT6
- antibodies-online: Search results for 4 available CNOT6 Proteins ranked by validation data
- Compare Top CNOT6 Proteins
-
Quality Products:
- Search GeneTex for Proteins for CNOT6
-
Abcam proteins for CNOT6
Assay Products
Domains & Families for CNOT6 Gene
Gene Families for CNOT6 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted intracellular proteins
Protein Domains for CNOT6 Gene
Suggested Antigen Peptide Sequences for CNOT6 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9ULM6- Family:
-
- Belongs to the CCR4/nocturin family.
Function for CNOT6 Gene
Molecular function for CNOT6 Gene
- UniProtKB/Swiss-Prot CatalyticActivity:
- Exonucleolytic cleavage of poly(A) to 5-AMP.
- UniProtKB/Swiss-Prot Function:
- Poly(A) nuclease with 3-5 RNase activity. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Involved in mRNA decay mediated by the major-protein-coding determinant of instability (mCRD) of the FOS gene in the cytoplasm. In the presence of ZNF335, enhances ligand-dependent transcriptional activity of nuclear hormone receptors, including RARA. The increase of ligand-dependent ESR1-mediated transcription is much smaller, if any. Mediates cell proliferation and cell survival and prevents cellular senescence.
Enzyme Numbers (IUBMB) for CNOT6 Gene
Phenotypes From GWAS Catalog for CNOT6 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003723 | RNA binding | IEA | -- |
| GO:0004518 | nuclease activity | IEA | -- |
| GO:0004527 | exonuclease activity | IEA | -- |
| GO:0004532 | exoribonuclease activity | IDA | 11889047 |
| GO:0004535 | poly(A)-specific ribonuclease activity | TAS | -- |
Phenotypes for CNOT6 Gene
- MGI mutant phenotypes for CNOT6:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for CNOT6:
Animal Models for CNOT6 Gene
- MGI Knock Outs for CNOT6:
-
- Cnot6 tm1a(KOMP)Wtsi
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for CNOT6
-
-
ViGene Biosciences lentiviral particle packaged cDNA for CNOT6 gene
- Search ViGene Biosciences for CNOT6
CRISPR Products
-
OriGene CRISPR knockouts for CNOT6
- genomics-online: gRNA clones - Search results for 108 available CNOT6 gene related products
- Overview of 108 available CNOT6 gene related products
- Applied Biological Materials CRISPR for CNOT6
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CNOT6
- GenScript: Design CRISPR guide RNA sequences for CNOT6
miRNA for CNOT6 Gene
- miRTarBase miRNAs that target CNOT6
-
- hsa-mir-1-3p (MIRT003851)
- hsa-mir-373-3p (MIRT004074)
- hsa-mir-193b-3p (MIRT016605)
- hsa-mir-130b-3p (MIRT020329)
- hsa-mir-9-5p (MIRT021485)
- hsa-mir-96-5p (MIRT027912)
- hsa-mir-19b-3p (MIRT031275)
- hsa-mir-15a-3p (MIRT038987)
- hsa-mir-769-5p (MIRT039160)
- hsa-mir-106b-5p (MIRT044283)
- hsa-mir-183-5p (MIRT047042)
- hsa-mir-4314 (MIRT502715)
- hsa-mir-23c (MIRT502716)
- hsa-mir-23b-3p (MIRT502717)
- hsa-mir-23a-3p (MIRT502718)
- hsa-mir-130a-5p (MIRT502719)
- hsa-mir-630 (MIRT502720)
- hsa-mir-6776-5p (MIRT502721)
- hsa-mir-6861-5p (MIRT502722)
- hsa-mir-4717-3p (MIRT502723)
- hsa-mir-4778-5p (MIRT502724)
- hsa-mir-1244 (MIRT502725)
- hsa-mir-186-5p (MIRT502726)
- hsa-mir-155-5p (MIRT513967)
- hsa-mir-621 (MIRT513968)
- hsa-mir-4725-5p (MIRT513969)
- hsa-mir-3146 (MIRT513970)
- hsa-mir-410-3p (MIRT513971)
- hsa-mir-3667-5p (MIRT513972)
- hsa-mir-10a-5p (MIRT513973)
- hsa-mir-10b-5p (MIRT513974)
- hsa-mir-620 (MIRT610032)
- hsa-mir-1270 (MIRT610033)
- hsa-mir-5706 (MIRT610034)
- hsa-mir-4782-5p (MIRT610035)
- hsa-mir-516b-5p (MIRT610036)
- hsa-mir-1299 (MIRT610037)
- hsa-mir-4683 (MIRT610038)
- hsa-mir-8485 (MIRT610039)
- hsa-mir-1238-3p (MIRT716966)
- hsa-mir-670-3p (MIRT716967)
- hsa-mir-6715b-3p (MIRT716968)
- hsa-mir-371a-5p (MIRT716969)
- hsa-mir-4729 (MIRT716970)
- hsa-mir-6715a-3p (MIRT716971)
- hsa-mir-19a-3p (MIRT727971)
- hsa-mir-29c-3p (MIRT734291)
- hsa-mir-1279 (MIRT783363)
miRNA Products
- Search ViGene Biosciences for CNOT6
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CNOT6
- Browse OriGene Inhibitory RNA Products For CNOT6
- genomics-online: shRNA clones - Search results for 108 available CNOT6 gene related products
- Overview of 108 available CNOT6 gene related products
- Search ViGene Biosciences for CNOT6
Clone Products
- Sino Biological Human cDNA Clone for CNOT6
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for CNOT6
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CNOT6
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for CNOT6
- Applied Biological Materials Clones for CNOT6
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for CNOT6
-
ViGene Biosciences adenoviral particle packaged cDNA for CNOT6 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for CNOT6 gene
- Search ViGene Biosciences for CNOT6
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CNOT6 Gene
Localization for CNOT6 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CNOT6 Gene
- Cytoplasm. Nucleus.
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| nucleus | 4 |
- Cytosol (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005829 | cytosol | TAS | -- |
| GO:0016020 | membrane | HDA,IDA | 19946888 |
| GO:0030014 | CCR4-NOT complex | IDA | 19558367 |
Pathways & Interactions for CNOT6 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Deadenylation-dependent mRNA decay |
.46
|
|
| 2 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 | ||
| 3 | Gene Expression |
.48
|
|
| 4 | TP53 Regulates Transcription of Cell Cycle Genes | ||
| 5 | Translational Control | ||
Pathways by source for CNOT6 Gene
1 Cell Signaling Technology pathway for CNOT6 Gene
1 KEGG pathway for CNOT6 Gene
Interacting Proteins for CNOT6 Gene
Selected Interacting proteins:
ENSP00000261951
Q9ULM6-CNOT6_HUMAN
for CNOT6 Gene via
STRING
UniProtKB
IID
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000289 | nuclear-transcribed mRNA poly(A) tail shortening | TAS | -- |
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0006417 | regulation of translation | IEA | -- |
| GO:0006977 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest | TAS | -- |
No data available for SIGNOR curated interactions for CNOT6 Gene
Drugs & Compounds for CNOT6 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Magnesium | Approved | Nutra | 0 |
Transcripts for CNOT6 Gene
mRNA/cDNA for CNOT6 Gene
- (9) REFSEQ mRNAs :
- (10) Additional mRNA sequences :
- (268) Selected AceView cDNA sequences:
- (7) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for CNOT6 Gene
CRISPR Products
-
OriGene CRISPR knockouts for CNOT6
- genomics-online: gRNA clones - Search results for 108 available CNOT6 gene related products
- Overview of 108 available CNOT6 gene related products
- Applied Biological Materials CRISPR for CNOT6
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CNOT6
- GenScript: Design CRISPR guide RNA sequences for CNOT6
miRNA Products
- Search ViGene Biosciences for CNOT6
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CNOT6
- Browse OriGene Inhibitory RNA Products For CNOT6
- genomics-online: shRNA clones - Search results for 108 available CNOT6 gene related products
- Overview of 108 available CNOT6 gene related products
- Search ViGene Biosciences for CNOT6
Clone Products
- Sino Biological Human cDNA Clone for CNOT6
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for CNOT6
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CNOT6
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for CNOT6
- Applied Biological Materials Clones for CNOT6
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | · | 2d | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7 | ^ | 8a | · | 8b | ^ | 9a | · | 9b | · | 9c | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||
| SP2: | - | ||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | ||||||||||||||||||||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - |
Expression for CNOT6 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
- Neural Tube (Nervous System)
- Eye (Sensory Organs)
This gene is overexpressed in Plasma (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CNOT6 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of CNOT6 Gene:
CNOT6SOURCE GeneReport for Unigene cluster for CNOT6 Gene:
Hs.608380Evidence on tissue expression from TISSUES for CNOT6 Gene
- Nervous system(4.6)
- Intestine(2.9)
Primer Products
-
OriGene qPCR primer pairs for CNOT6
- genomics-online: primer clones - Search results for 108 available CNOT6 gene related products
- Overview of 108 available CNOT6 gene related products
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CNOT6 Gene
Orthologs for CNOT6 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | CNOT6 33 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | CNOT6 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | CNOT6 34 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | CNOT6 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | CNOT6 33 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Cnot6 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Cnot6 33 16 34 |
|
||
| chicken (Gallus gallus) |
Aves | CNOT6 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | CNOT6 34 |
|
OneToOne | |
| zebrafish (Danio rerio) |
Actinopterygii | CNOT6 (2 of 2) 34 |
|
OneToMany | |
| cnot6 33 34 |
|
||||
| Dr.24978 33 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | twin 34 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | ccr-4 34 |
|
OneToMany | |
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | CCR4 34 36 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToMany |
- Species where no ortholog for CNOT6 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
Paralogs for CNOT6 Gene
(1) SIMAP similar genes for CNOT6 Gene using alignment to 3 proteins:
Variants for CNOT6 Gene
| SNP ID | Clin | Chr 05 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000017288 | -- | 180,530,581(+) | G/T | genic_upstream_transcript_variant, intron_variant | |
| rs1000084460 | -- | 180,575,255(+) | T/A | 3_prime_UTR_variant, non_coding_transcript_variant | |
| rs1000173563 | -- | 180,521,253(+) | C/T | genic_upstream_transcript_variant, intron_variant | |
| rs1000174783 | -- | 180,565,468(+) | C/T | intron_variant | |
| rs1000209445 | -- | 180,566,551(+) | A/G | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv1078210 | CNV | deletion | 17803354 |
| esv1787252 | CNV | deletion | 17803354 |
| esv2731343 | CNV | deletion | 23290073 |
| esv2731344 | CNV | deletion | 23290073 |
| esv2762572 | CNV | gain | 21179565 |
| esv2860569 | CNV | duplication | 24192839 |
| esv3607782 | CNV | gain | 21293372 |
| esv3607783 | CNV | gain | 21293372 |
| esv991928 | CNV | deletion | 20482838 |
| esv998085 | CNV | deletion | 20482838 |
| nsv1019519 | CNV | gain | 25217958 |
| nsv1026417 | CNV | gain | 25217958 |
| nsv478393 | CNV | novel sequence insertion | 20440878 |
| nsv509110 | CNV | insertion | 20534489 |
| nsv509111 | CNV | insertion | 20534489 |
| nsv519380 | CNV | loss | 19592680 |
| nsv823366 | CNV | loss | 20364138 |
| nsv830564 | CNV | gain | 17160897 |
Residual Variation Intolerance Score:
23.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.43;
28.12% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CNOT6 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- CNOT6
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CNOT6 Gene
Disorders for CNOT6 Gene
Additional Disease Information for CNOT6
- Genetic Association Database
- (GAD)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for CNOT6 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CNOT6 Gene
Publications for CNOT6 Gene
- CCR4-NOT deadenylates mRNA associated with RNA-induced silencing complexes in human cells. (PMID: 20065043) Piao X … Belasco JG (Molecular and cellular biology 2010) 3 4 22 58
- Components of the CCR4-NOT complex function as nuclear hormone receptor coactivators via association with the NRC-interacting Factor NIF-1. (PMID: 18180299) Garapaty S … Samuels HH (The Journal of biological chemistry 2008) 3 4 22 58
- UNR, a new partner of poly(A)-binding protein, plays a key role in translationally coupled mRNA turnover mediated by the c-fos major coding-region determinant. (PMID: 15314026) Chang TC … Shyu AB (Genes & development 2004) 3 4 22 58
- CCR4, a 3'-5' poly(A) RNA and ssDNA exonuclease, is the catalytic component of the cytoplasmic deadenylase. (PMID: 11889047) Chen J … Denis CL (The EMBO journal 2002) 2 3 4 58
- The Ccr4a (CNOT6) and Ccr4b (CNOT6L) deadenylase subunits of the human Ccr4-Not complex contribute to the prevention of cell death and senescence. (PMID: 21233283) Mittal S … Winkler GS (Molecular biology of the cell 2011) 3 4 58
Products for CNOT6 Gene
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- Custom Antibody ServicesOriGene Antibodies for CNOT6
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- OriGene Purified Proteins for CNOT6
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- Origene Custom Protein Services for CNOT6
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CNOT6
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- OriGene qPCR primer pairs for CNOT6
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- GenScript Custom Purified and Recombinant Proteins Services for CNOT6
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- GenScript Custom overexpressing Cell Line Services for CNOT6
- GenScript: Design CRISPR guide RNA sequences for CNOT6
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for CNOT6
- Cell Signaling Technology (CST) Antibodies for CNOT6 (CNOT6)
- Search for Antibodies & Assays
- Sino Biological Human cDNA Clone for CNOT6
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Recombinant Proteins
- Sino Biological Antibodies for CNOT6
- Browse Sino Biological Assays
- Browse Sino Biological ELISA Kits
- Browse Sino Biological ELISA Pair Sets
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- Browse Sino Biological Control Vectors
- Sino Biological Transfection Reagent
- Sino Biological Anti-His Tag Antibody
- Novus Biologicals Antibodies for CNOT6
- Novus Biologicals proteins for CNOT6
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Abcam antibodies for CNOT6
- Abcam proteins for CNOT6
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Browse Antibodies at Cloud-Clone Corp.
- Browse Proteins at Cloud-Clone Corp.
- Browse Assay Kits at Cloud-Clone Corp.
- Browse Knockouts at Cloud-Clone Corp.
- Browse Knockins at Cloud-Clone Corp.
- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- Invitrogen Antibodies for CNOT6
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Cyagen custom Knockout/knockin (KOKI) mouse models for CNOT6
- VectorBuilder custom plasmid, inducible vectors for CNOT6
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CNOT6
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for CNOT6
- antibodies-online: Search results for 34 available CNOT6 Antibodies ranked by validation data
- Compare Top CNOT6 Antibodies
- antibodies-online: Search results for available CNOT6 related products ranked by validation data
- antibodies-online: Search results for 4 available CNOT6 Proteins ranked by validation data
- Compare Top CNOT6 Proteins
- Quality Products:
- GeneTex CNOT6 antibody for CNOT6
- Search GeneTex for Proteins for CNOT6
- ViGene Biosciences adenoviral particle packaged cDNA for CNOT6 gene
- ViGene Biosciences lentiviral particle packaged cDNA for CNOT6 gene
- Search ViGene Biosciences for CNOT6
- Santa Cruz Biotechnology (SCBT) Antibodies for CNOT6
- Search Santa Cruz Biotechnology (SCBT) for CNOT6 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for CNOT6
- Horizon Cell Lines for CNOT6
- genomics-online: cdna clones - Search results for 108 available CNOT6 gene related products
- Overview of 108 available CNOT6 gene related products
- orf clones - Search results for 108 available CNOT6 gene related products
- Overview of 108 available CNOT6 gene related products
- genomics-online: gRNA clones - Search results for 108 available CNOT6 gene related products
- Overview of 108 available CNOT6 gene related products
- genomics-online: primer clones - Search results for 108 available CNOT6 gene related products
- Overview of 108 available CNOT6 gene related products
- genomics-online: shRNA clones - Search results for 108 available CNOT6 gene related products
- Overview of 108 available CNOT6 gene related products
Sources for CNOT6 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew