Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
- GeneCards Team
- Our Publications
- Citing GeneCards
- Licensing Agreement
- Weizmann Institute
- LifeMap Sciences Inc
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CNOT6 Gene

protein-coding GIFtS: 60
GCID: GC05P179921

CCR4-NOT Transcription Complex, Subunit 6

3 related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
CCR4-NOT Transcription Complex, Subunit 6¹ ²		KIAA1194³ ⁵
CCR4² ³ ⁵		Carbon Catabolite Repression 4 Protein²
Carbon Catabolite Repressor Protein 4 Homolog² ³		CCR4-NOT Transcription Complex Subunit 6²
Cytoplasmic Deadenylase² ³		CCR4a³
EC 3.1.13.4³ ⁸		CCR4 Carbon Catabolite Repression 4-Like³

External Ids:	HGNC: 14099¹	Entrez Gene: 57472²	Ensembl: ENSG00000113300⁷	OMIM: 608951⁵	UniProtKB: Q9ULM6³

Export aliases for CNOT6 gene to outside databases

Previous GC identifers: GC00U990842 GC05P179855 GC05P179856 GC05P174644

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CNOT6 Gene:

The protein encoded by this gene is a subunit of the CCR4-NOT core transcriptional regulation complex. The encoded

protein has a 3'-5' RNase activity and prefers polyadenylated substates. (provided by RefSeq, Jul 2008)

GeneCards Summary for CNOT6 Gene:

CNOT6 (CCR4-NOT transcription complex, subunit 6) is a protein-coding gene. Diseases associated with CNOT6 include food allergy, and alcoholism, and among its related super-pathways are Deadenylation-dependent mRNA decay and Metabolism of RNA. GO annotations related to this gene include RNA binding and poly(A)-specific ribonuclease activity. An important paralog of this gene is ANGEL1.

UniProtKB/Swiss-Prot: CNOT6_HUMAN, Q9ULM6

Function: Poly(A) nuclease with 3'-5' RNase activity. Catalytic component of the CCR4-NOT complex which is one of the

major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation,

miRNA-mediated repression, translational repression during translational initiation and general transcription

regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Involved in mRNA

decay mediated by the major-protein-coding determinant of instability (mCRD) of the FOS gene in the cytoplasm. In the

presence of ZNF335, enhances ligand-dependent transcriptional activity of nuclear hormone receptors, including RARA.

The increase of ligand-dependent ESR1-mediated transcription is much smaller, if any. Mediates cell proliferation and

cell survival and prevents cellular senescence

summary for CNOT6 Gene:

Chemokines (chemotactic cytokines) belong to a family of chemoattractant molecules involved in the directed

migration of immune cells. Over fifty human chemokines have been identified that can be categorised into

four groups; CC, CXC, CX3C and C (XCL1 and XCL2); depending on the spacing of their first two cysteine

residues. Chemokines exert their effects by binding to G-protein-coupled chemokine receptors on the surface

of cells, predominantly leukocytes. Eighteen human chemokine receptors have been identified that are

classified according to the class of chemokines that they bind. The major function of chemokines is to

regulate leukocyte trafficking in hematopoiesis and in innate and adaptive immunity. Other functions include

angiogenic activity, apoptosis, T-cell differentiation and phagocyte activation. Inadvertent activation of

chemokine receptors leads to autoimmunity by inappropriately targeting self antigens for destruction by

cytotoxic T-cells and macrophages.

Gene Wiki entry for CNOT6 Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000005.9 NT_023133.13 NC_018916.2

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CNOT6 gene promoter:
AP-2rep FOXF2 AP-4 E47 RORalpha1 FOXJ2 (long isoform) Hand1 FOXO1a FOXJ2 FOXO1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CNOT6 promoter sequence

Search SABiosciences Chromatin IP Primers for CNOT6

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CNOT6

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q35.3 Ensembl cytogenetic band: 5q35.3 HGNC cytogenetic band: 5q35.3

CNOT6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CNOT6 gene location

GeneLoc information about chromosome 5 GeneLoc Exon Structure

GeneLoc location for GC05P179921: view genomic region (about GC identifiers)

Start:	179,921,412 bp from pter	End:	180,005,405 bp from pter
Size:	83,994 bases	Orientation:	plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CNOT6_HUMAN, Q9ULM6 (See protein sequence)

Recommended Name: CCR4-NOT transcription complex subunit 6

Size: 557 amino acids; 63307 Da

Cofactor: Magnesium

Subunit: Component of the CCR4-NOT complex; distinct complexes seem to exist that differ in the participation of

probably mutually exclusive catalytic subunits; the complex contains two deadenylase subunits, CNOT6 or CNOT6L, and

CNOT7 or CNOT8. Interacts with UNR and ZNF335

Subcellular location: Cytoplasm (Probable). Nucleus (Probable)

Secondary accessions: A7MD46 D3DWR0

Explore the universe of human proteins at neXtProt for CNOT6: NX_Q9ULM6

Explore proteomics data for CNOT6 at MOPED

Post-translational modifications:

View modification sites using PhosphoSitePlus

View neXtProt modification sites for NX_Q9ULM6

2 DME Specific Peptides for CNOT6 (Q9ULM6)

PKSRARTM

NRVMTKDNI

CNOT6 Protein expression data from MOPED¹, PaxDb² and MAXQB³ : About this image

REFSEQ proteins: NP_056270.2

ENSEMBL proteins:

ENSP00000377024 ENSP00000422087 ENSP00000261951

Reactome Protein details: Q9ULM6
Human Recombinant Protein Products for CNOT6:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells Browse OriGene Protein Over-expression Lysates OriGene Custom MassSpec OriGene Custom Protein Services for CNOT6
	GenScript Custom Purified and Recombinant Proteins Services for CNOT6
	Novus Biologicals CNOT6 Proteins
	Browse Sino Biological Recombinant Proteins Browse Sino Biological Cell Lysates
	Browse ProSpec Recombinant Proteins
	Cloud-Clone Corp. Proteins for CNOT6

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--
GO:0005829	cytosol	TAS	--
GO:0030014	CCR4-NOT complex	IDA	19558367

CNOT6 for ontologies About GeneDecksing

CNOT6 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for CNOT6
	GenScript Custom Superior Antibodies Services for CNOT6
	Novus Biologicals CNOT6 Antibodies
	Abcam antibodies for CNOT6
	Cloud-Clone Corp. Antibodies for CNOT6
	Search ThermoFisher Antibodies for CNOT6
	LSBio Antibodies in human, mouse, rat for CNOT6

Assay Products for CNOT6:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Assay Services for CNOT6
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for CNOT6
	Browse Enzo Life Sciences for kits & assays
	Cloud-Clone Corp. ELISAs for CNOT6 Cloud-Clone Corp. CLIAs for CNOT6

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

3 InterPro protein domains:

IPR001611 Leu-rich_rpt

IPR003591 Leu-rich_rpt_typical-subtyp

IPR005135 Endo/exonuclease/phosphatase

Graphical View of Domain Structure for InterPro Entry Q9ULM6

ProtoNet protein and cluster: Q9ULM6

UniProtKB/Swiss-Prot: CNOT6_HUMAN, Q9ULM6

Similarity: Belongs to the CCR4/nocturin family

Similarity: Contains 4 LRR (leucine-rich) repeats

CNOT6 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: CNOT6_HUMAN, Q9ULM6

Function: Poly(A) nuclease with 3'-5' RNase activity. Catalytic component of the CCR4-NOT complex which is one of the

major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation,

miRNA-mediated repression, translational repression during translational initiation and general transcription

regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Involved in mRNA

decay mediated by the major-protein-coding determinant of instability (mCRD) of the FOS gene in the cytoplasm. In the

presence of ZNF335, enhances ligand-dependent transcriptional activity of nuclear hormone receptors, including RARA.

The increase of ligand-dependent ESR1-mediated transcription is much smaller, if any. Mediates cell proliferation and

cell survival and prevents cellular senescence

Catalytic activity: Exonucleolytic cleavage of poly(A) to 5'-AMP

Enzyme Number (IUBMB): EC 3.1.13.4¹ ²

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003723	RNA binding	IEA	--
GO:0004532	exoribonuclease activity	IDA	11889047
GO:0004535	poly(A)-specific ribonuclease activity	TAS	--
GO:0005515	protein binding	IPI	11747467
GO:0046872	metal ion binding	IEA	--

CNOT6 for ontologies About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Custom generated mouse model solutions for CNOT6

inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CNOT6

miRNA Products:		miRTarBase miRNAs that target CNOT6: hsa-mir-373 (MIRT004074), hsa-mir-1 (MIRT003851)


		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CNOT6
		8/84 QIAGEN miScript miRNA Assays for microRNAs that regulate CNOT6 (see all 84):
		hsa-miR-520e hsa-miR-193a-3p hsa-miR-128 hsa-miR-30d hsa-miR-138-2* hsa-miR-371-5p hsa-miR-519a hsa-miR-30a

		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene RNAi products in human, mouse, rat for CNOT6
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CNOT6
		Sirion Biotech Custom design and validation of potent shRNA sequences against CNOT6

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for CNOT6
			Sirion Biotech Customized adenovirus for overexpression of CNOT6 Customized adenovirus for potent knockdown of CNOT6

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene clones in human, mouse for CNOT6 (see all 7) OriGene ORF clones in mouse, rat for CNOT6 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: CNOT6 (NM_015455)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CNOT6
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CNOT6

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CNOT6
		Search LifeMap BioReagents cell lines for CNOT6
		Sirion Biotech Customized stable knockdown cell line services for CNOT6 Customized inducible knockdown cell line services for CNOT6 Customized stable overexpressing cell line services for CNOT6 Customized inducible overexpressing cell line services for CNOT6

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CNOT6

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for CNOT6 About

See pathways by source

SuperPath

Contained pathways About

Deadenylation-dependent mRNA decay

	Deadenylation-dependent mRNA decay	0.49			Deadenylation of mRNA	0.47
	RNA degradation	0.49

Metabolism of mRNA

Metabolism of mRNA

0.92

Metabolism of RNA

0.92

Generic Transcription Pathway

Gene Expression

0.47

Pathways by source See SuperPaths
Show all pathways

5 Reactome Pathways for CNOT6

	Deadenylation of mRNA
	Deadenylation-dependent mRNA decay
	Metabolism of RNA
	Metabolism of mRNA
	Gene Expression

1 Kegg Pathway (Kegg details for CNOT6):

RNA degradation

CNOT6 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for CNOT6

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/133 Interacting proteins for CNOT6 (Q9ULM6^{1, 3} ENSP00000261951⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 133)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CNOT8	Q9UFF9¹^,³, ENSP00000285896⁴	EBI-2104530,EBI-742299 I2D: score=8 STRING: ENSP00000285896
CNOT1	A5YKK6¹^,³, ENSP00000320949⁴	STRING: ENSP00000320949 EBI-2104530,EBI-1222758 I2D: score=6
ENSG00000206286	Q8N1B4³	I2D: score=1
ENSG00000224455	Q8N1B4³	I2D: score=1
ENSG00000225590	Q8N1B4³	I2D: score=1

About this table

Gene Ontology (GO): 14 biological process terms (GO ID links to tree view) (see first 5): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000288	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	TAS	--
GO:0000289	nuclear-transcribed mRNA poly(A) tail shortening	TAS	--
GO:0006351	transcription, DNA-dependent	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	IEA	--
GO:0006417	regulation of translation	IEA	--
GO:0008284	positive regulation of cell proliferation	IMP	--
GO:0010467	gene expression	TAS	--
GO:0010606	positive regulation of cytoplasmic mRNA processing body assembly	IMP	--
GO:0016070	RNA metabolic process	TAS	--
GO:0016071	mRNA metabolic process	TAS	--
GO:0035195	gene silencing by miRNA	TAS	--
GO:0043928	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	IDA	--
GO:0070966	nuclear-transcribed mRNA catabolic process, no-go decay	IMP	15314026
GO:2000327	positive regulation of ligand-dependent nuclear receptor transcription coactivator activity	IDA	18180299

CNOT6 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, IUPHAR, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Compounds for CNOT6 available from Tocris Bioscience About this table

Compound	Action	CAS #
RS 504393	Highly selective CCR2 chemokine receptor antagonist	[300816-15-3]
Maraviroc	Selective CCR5 antagonist	[376348-65-1]
SB 225002	Potent and selective CXCR2 antagonist	[182498-32-4]
SB 265610	Potent CXCR2 antagonist	[211096-49-0]
TC 14012	CXCR4 antagonist; CXCR7 agonist	[368874-34-4]

1 HMDB Compound for CNOT6 About this table

Compound	Synonyms	CAS #	PubMed Ids
Magnesium	Magnesium (see all 2)	7439-95-4	--

Search CenterWatch for drugs/clinical trials and news about CNOT6

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CNOT6 gene:

NM_015455.3

Unigene Cluster for CNOT6:

CCR4-NOT transcription complex, subunit 6

Hs.608380 [show with all ESTs]

Unigene Representative Sequence: BC152469

6 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000510148 ENST00000393356(uc010jld.3) ENST00000507016 ENST00000502447

ENST00000504343 ENST00000261951(uc003mlx.3 uc010jle.3)

miRNA Products:
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CNOT6
		8/84 QIAGEN miScript miRNA Assays for microRNAs that regulate CNOT6 (see all 84):
		hsa-miR-520e hsa-miR-193a-3p hsa-miR-128 hsa-miR-30d hsa-miR-138-2* hsa-miR-371-5p hsa-miR-519a hsa-miR-30a

		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene RNAi products in human, mouse, rat for CNOT6
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CNOT6
		Sirion Biotech Custom design and validation of potent shRNA sequences against CNOT6

Clone Products:		OriGene clones in human, mouse for CNOT6 (see all 7) OriGene ORF clones in mouse, rat for CNOT6 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: CNOT6 (NM_015455)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CNOT6
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CNOT6

Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for CNOT6
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat CNOT6
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CNOT6
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CNOT6

Additional mRNA sequence:

AB033020.1 AK023599.1 AK314752.1 AL110144.1 BC015331.1 BC027476.1 BC073142.1 BC090918.1

BC114958.1 BC152469.1

10 DOTS entries:

DT.115578 DT.101979531 DT.99934212 DT.100775630 DT.101957004 DT.92435297 DT.92435303 DT.95345830

DT.100737457 DT.97799052

24/268 AceView cDNA sequences (see all 268):

AB033020 CA416373 AA361774 AA235905 CR617731 AI810439 AA603028 BM729275

CB306950 N90713 CR601971 BG231763 AA630737 AA227943 BC027476 AI744474

BP379655 CB959839 AA227814 BF476475 AI276566 AA479504 BU193854 AI187427

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for CNOT6 (see all 7) About this scheme

ExUns:	1	^	2a	·	2b	·	2c	·	2d	^	3	^	4a	·	4b	^	5a	·	5b	^	6a	·	6b	^	7	^	8a	·	8b	^	9a	·	9b	·	9c	^	10	^	11	^	12	^	13
SP1:			-		-		-		-																-				-
SP2:																									-
SP3:											-
SP4:
SP5:											-										-		-		-

ECgene alternative splicing isoforms for CNOT6

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CNOT6 expression in normal human tissues (normalized intensities) CNOT6 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: TGTCTTCCGT

About this image

CNOT6 expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database

5/15 selected tissues (see all 15) fully expand


Brain (Nervous System) fully expand to see all 8 entries
Thalamus
brain/midbrain

Cartilage (Muscoskeletal System) fully expand to see all 5 entries
Rostral Chondrocranium

Neural Tube (Nervous System) fully expand to see all 3 entries
Metencephalon

Heart (Cardiovascular System) fully expand to see all 2 entries
heart/atrium

Eye (Sensory Organs) fully expand to see all 2 entries
Retina

See CNOT6 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CNOT6

SOURCE GeneReport for Unigene cluster: Hs.608380

SABiosciences Custom PCR Arrays for CNOT6

Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for CNOT6
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat CNOT6
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CNOT6
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CNOT6

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CNOT6

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals and fungi.

Orthologs for CNOT6 gene from 7/15 species (see all 15) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Cnot6^{1 , 5}	CCR4-NOT transcription complex, subunit 6^{1, 5}	92.27(n)¹ 96.01(a)¹		11 (29.76 cM)⁵ 104625¹ NM_212484.1¹ NP_997649.1¹ 49671503⁵
chicken (Gallus gallus)	Aves	CNOT6¹	CCR4-NOT transcription complex, subunit 6	86.18(n) 95.69(a)		416293 XM_414612.3 XP_414612.3
lizard (Anolis carolinensis)	Reptilia	CNOT6⁶	Uncharacterized protein	93(a)	1 ↔ 1	2(141011047-141051754)
zebrafish (Danio rerio)	Actinopterygii	Dr.24978²	Danio rerio mRNA similar to KIAA1194 (cDNA clone IMAGE5413 more	78.97(n)		BC058309.1
fruit fly (Drosophila melanogaster)	Insecta	twin¹	CG31137-PA	59.3(n) 59.05(a)		42880 NM_170128.1 NP_732964.1
worm (Caenorhabditis elegans)	Secernentea	ccr-4¹	Protein CCR-4	57.1(n) 51.76(a)		178184 NM_001028437.1 NP_001023608.1
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	CCR4(YAL021C)⁴	Component of the CCR4-NOT transcriptional complex, more	--		1(113359-110846) 851212 NP_009381.1

ENSEMBL Gene Tree for CNOT6 (if available)
TreeFam Gene Tree for CNOT6 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CNOT6 gene

ANGEL1² CCRN4L² PDE12² ANGEL2² CNOT6L²

1 SIMAP similar gene for CNOT6 using alignment to 3 protein entries: CNOT6_HUMAN (see all proteins):

CNOT6L

CNOT6 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 5 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs73363219^1,2	C,F	--	179919427(+)	`CCGCAC/TAACTC`	1	--	us2k¹		1		WA	118
rs141118409^1,2	C	--	179919464(+)	`GGGATG/TGCCAC`	1	--	us2k¹		0	--	--	--	--
rs56755455^1,2	C	--	179919468(+)	`TGGCCA/CCAGGC`	1	--	us2k¹		4		NA WA EA	360
rs182840291^1,2		--	179919550(+)	`ATGGCA/GCTAGA`	1	--	us2k¹		0	--	--	--	--
rs150269797^1,2	C	--	179919589(+)	`GCAGTA/GCCAAG`	1	--	us2k¹		0	--	--	--	--
rs62405496^1,2	C,F	--	179919618(+)	`CGTGCT/CGGGGA`	1	--	us2k¹		6		NA WA EA	364
rs62405497^1,2	C	--	179919912(+)	`ATATAG/CCTCAA`	1	--	us2k¹		7		NA WA EA	366
rs10072835^1,2	C,F	--	179919913(+)	`TATAGC/GTCAAA`	1	--	us2k¹		2		WA NA	238
rs72811127^1,2	C	--	179919918(+)	`CTCAAT/ATTTTT`	1	--	us2k¹		1		NA	2
rs71577044^1,2	C	--	179919924(+)	`TTTTT-/C/C TT/TTTTTTT`	2	--	us2k¹ cds¹		1		NA	2

HapMap Linkage Disequilibrium report for CNOT6 (179921412 - 180005405 bp)

Structural Variations
Database of Genomic Variants (DGV) 10/11 variations for CNOT6 (see all 11): About this table

Variant ID	Type	Subtype	PubMed ID
esv998085	CNV	Deletion	20482838
esv991928	CNV	Deletion	20482838
esv2731343	CNV	Deletion	23290073
esv2731344	CNV	Deletion	23290073
esv1078210	CNV	Deletion	17803354
esv1787252	CNV	Deletion	17803354
nsv509111	CNV	Insertion	20534489
nsv509110	CNV	Insertion	20534489
nsv519380	CNV	Loss	19592680
nsv823366	CNV	Loss	20364138

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CNOT6

DNA2.0 Custom Variant and Variant Library Synthesis for CNOT6

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CNOT6 for disorders           About GeneDecksing

OMIM gene information: 608951    OMIM disorders: --

3 diseases for CNOT6:    About MalaCards

food allergy alcoholism gastric cancer

1 Novoseek inferred disease relationship for CNOT6 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
tumors	0	1	17641067 (1)

Genetic Association Database (GAD): CNOT6

Export disorders for CNOT6 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CNOT6 gene, integrated from 9 sources (see all 41):
(articles sorted by number of sources associating them with CNOT6)

Utopia: connect your pdf to the dynamic
world of online information

CCR4, a 3'-5' poly(A) RNA and ssDNA exonuclease, is the catalytic component of the cytoplasmic deadenylase. (PubMed id 11889047)^{1, 2, 3} Chen J.... Denis C.L. (2002)
Components of the CCR4-NOT complex function as nuclear hormone receptor coactivators via association with the NRC-interacting Factor NIF-1. (PubMed id 18180299)^{1, 2, 9} Garapaty S....Samuels H.H. (2008)
UNR, a new partner of poly(A)-binding protein, plays a key role in translationally coupled mRNA turnover mediated by the c-fos major coding-region determinant. (PubMed id 15314026)^{1, 2, 9} Chang T.-C.... Shyu A.-B. (2004)
The Ccr4a (CNOT6) and Ccr4b (CNOT6L) deadenylase subu nits of the human Ccr4-Not complex contribute to the prevention of cell death a nd senescence. (PubMed id 21233283)^{1, 2} Mittal S....Winkler G.S. (2011)
Human Ccr4-Not complexes contain variable deadenylase subunits. (PubMed id 19558367)^{1, 2} Lau N.C....Timmers H.T. (2009)
Identification of four families of yCCR4- and Mg2+-dependent endonuclease-related proteins in higher eukaryotes, and characterization of orthologs of yCCR4 with a conserved leucine-rich repeat essential for hCAF1/hPOP2 binding. (PubMed id 11747467)^{1, 2} Dupressoir A....Heidmann T. (2001)
Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10574462)^{1, 2} Nagase T.... Ohara O. (1999)
CCR4-NOT deadenylates mRNA associated with RNA-induce d silencing complexes in human cells. (PubMed id 20065043)^{2, 9} Piao X....Belasco J.G. (2010)
Isolation and characterization of human orthologs of yeast CCR4-NOT complex subunits. (PubMed id 10637334)^{1, 9} Albert T.K....Timmers H.T. (2000)
Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)¹ Udeshi N.D....Carr S.A. (2012)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 57472	HGNC: 14099	AceView: KIAA1194	Ensembl:ENSG00000113300	euGenes: HUgn57472
ECgene: CNOT6	Kegg: 57472	H-InvDB: CNOT6

(According to HUGE)
About This Section

HUGE: KIAA1194

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CNOT6	Pharmacogenomics, SNPs, Pathways

Intellectual Property for CNOT6 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for CNOT6 gene:
Search GeneIP for patents involving CNOT6

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Protease Activity Assays and Reagents		Browse Recombinant/Natural Proteins
	Browse Stem Cell Products		Browse Tocris Biochemicals & Compounds
	Browse cDNA Clones		Browse Proteome Profiler Antibody Arrays

	Browse OriGene Antibodies		OriGene RNAi products in human, mouse, rat for CNOT6
	Browse OriGene qPCR primer pairs and template standards		Browse OriGene Protein Over-expression Lysates
	OriGene Custom Mass Spec		OriGene clones in human, mouse for CNOT6
	OriGene qSTAR qPCR primer pairs in human, mouse for CNOT6		Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
	OriGene ORF clones in mouse, rat for CNOT6		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for CNOT6		OriGene Custom Protein Services for CNOT6

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CNOT6
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CNOT6
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CNOT6
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CNOT6
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CNOT6
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CNOT6

	GenScript Custom Purified and Recombinant Proteins Services for CNOT6		GenScript cDNA clones with any tag delivered in your preferred vector for CNOT6
	GenScript Custom Assay Services for CNOT6		GenScript Custom Superior Antibodies Services for CNOT6
	GenScript Custom overexpressing Cell Line Services for CNOT6		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in CNOT6 promoter
	Search Chromatin IP Primers for CNOT6
	RT² qPCR Primer Assay in human, mouse, rat CNOT6
	GNC Network for CNOT6
	SABiosciences Custom PCR Arrays for CNOT6

Tocris compounds for CNOT6

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological Cell Lysates
	Browse Sino Biological cDNA Clones
	4000+ Proteins
	Search Sino Biological for antibodies, proteins & pathways
	Protein Production Services
	Transfection Reagents
	Protein A/G/L resins
	Isotyping reagents

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	CNOT6 antibodies
	CNOT6 proteins

	Antibodies for CNOT6
	See all of Abcam's Antibodies, Kits and Proteins for CNOT6
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

	Proteins for CNOT6
	Antibodies for CNOT6
	ELISAs for CNOT6
	CLIAs for CNOT6

Search LifeMap BioReagents cell lines for CNOT6

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CNOT6

	Browse SwitchGear 3'UTR luciferase reporter plasmids for CNOT6
	SwitchGear Promoter luciferase reporter plasmids for CNOT6

Search ThermoFisher Antibodies for CNOT6

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CNOT6

	inGenious Targeting Laboratory - Custom generated mouse model solutions for CNOT6
	inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CNOT6

Customized:

	stable knockdown cell line services for CNOT6
	inducible knockdown cell line services for CNOT6
	design and validation of potent shRNA sequences against CNOT6
	adenovirus for potent knockdown of CNOT6
	stable overexpressing cell line services for CNOT6
	inducible overexpressing cell line services for CNOT6
	adenovirus for overexpression of CNOT6

LSBio Antibodies in human, mouse, rat for CNOT6

GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013

View Random Gene

Category			TGFB1 (GIFtS: 73) transforming growth factor, beta 1
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes CNOT6 gene at Home site.

hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4

Advanced Search

Export list of displayed genes

CNOT6 Gene

CCR4-NOT Transcription Complex, Subunit 6

Aliases
for CNOT6 gene

Summaries
for CNOT6 gene

Genomic Views
for CNOT6 gene

Proteins
for CNOT6 gene

Protein Domains /
Families
for CNOT6 gene

Function
for CNOT6 gene

Pathways & Interactions
for CNOT6 gene

Drugs & Compounds
for CNOT6 gene

Transcripts
for CNOT6 gene

Expression
for CNOT6 gene

Orthologs
for CNOT6 gene

Paralogs
for CNOT6 gene

Genomic Variants
for CNOT6 gene

Disorders / Diseases
for CNOT6 gene

Publications
for CNOT6 gene

External Searches for CNOT6 gene

Genome Databases showing CNOT6 gene

Other Databases showing CNOT6 gene

Specialized Databases showing CNOT6 gene

Intellectual Property
for CNOT6 gene

Products
for CNOT6 gene

View Random Gene

Advanced Search

Export list of displayed genes

CNOT6 Gene

CCR4-NOT Transcription Complex, Subunit 6

Aliasesfor CNOT6 gene

Summariesfor CNOT6 gene

Genomic Viewsfor CNOT6 gene

Proteinsfor CNOT6 gene

Protein Domains /Familiesfor CNOT6 gene

Functionfor CNOT6 gene

Pathways & Interactionsfor CNOT6 gene

Drugs & Compoundsfor CNOT6 gene

Transcriptsfor CNOT6 gene

Expression for CNOT6 gene

Orthologsfor CNOT6 gene

Paralogsfor CNOT6 gene

Genomic Variantsfor CNOT6 gene

Disorders / Diseasesfor CNOT6 gene

Publicationsfor CNOT6 gene

External Searches for CNOT6 gene

Genome Databases showing CNOT6 gene

Other Databases showing CNOT6 gene

Specialized Databases showing CNOT6 gene

Intellectual Propertyfor CNOT6 gene

Productsfor CNOT6 gene

View Random Gene

Aliases
for CNOT6 gene

Summaries
for CNOT6 gene

Genomic Views
for CNOT6 gene

Proteins
for CNOT6 gene

Protein Domains /
Families
for CNOT6 gene

Function
for CNOT6 gene

Pathways & Interactions
for CNOT6 gene

Drugs & Compounds
for CNOT6 gene

Transcripts
for CNOT6 gene

Expression
for CNOT6 gene

Orthologs
for CNOT6 gene

Paralogs
for CNOT6 gene

Genomic Variants
for CNOT6 gene

Disorders / Diseases
for CNOT6 gene

Publications
for CNOT6 gene

Intellectual Property
for CNOT6 gene

Products
for CNOT6 gene