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CNOT4 Gene

protein-coding   GIFtS: 61
GCID: GC07M135046

CCR4-NOT Transcription Complex, Subunit 4


(Previous symbol: NOT4)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
CCR4-NOT Transcription Complex, Subunit 41 2     CLONE2432
NOT41 2 3 5     NOT4H2
Potential Transcriptional Repressor NOT4Hp2 3     CCR4-NOT Transcription Complex Subunit 42
CCR4-Associated Factor 42 3     NOT4 (Negative Regulator Of Transcription 4, Yeast) Homolog2
E3 Ubiquitin-Protein Ligase CNOT42 3     EC 6.3.2.-3

External Ids:    HGNC: 78801   Entrez Gene: 48502   Ensembl: ENSG000000808027   OMIM: 6049115   UniProtKB: O956283   

Export aliases for CNOT4 gene to outside databases

Previous GC identifers: GC07M133389 GC07M134448 GC07M134462 GC07M134503 GC07M134697 GC07M129349


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CNOT4 Gene:
The protein encoded by this gene is a subunit of the CCR4-NOT complex, a global transcriptional regulator. The
encoded protein interacts with CNOT1 and has E3 ubiquitin ligase activity. Several transcript variants encoding
different isoforms have been found for this gene.(provided by RefSeq, Jul 2010)

GeneCards Summary for CNOT4 Gene:
CNOT4 (CCR4-NOT transcription complex, subunit 4) is a protein-coding gene. Diseases associated with CNOT4 include choroiditis. GO annotations related to this gene include ubiquitin-protein ligase activity and RNA binding.

UniProtKB/Swiss-Prot: CNOT4_HUMAN, O95628
Function: Has E3 ubiquitin ligase activity. Involved in activation of the JAK/STAT pathway




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000007.14  NC_018918.2  NT_007933.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the CNOT4 gene promoter:
         HOXA9   HOXA9B   GATA-3   GATA-2   GATA-1   Meis-1b   AREB6   HSF2   Pax-4a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): CNOT4 promoter sequence
   Search Chromatin IP Primers for CNOT4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CNOT4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q33   Ensembl cytogenetic band:  7q33   HGNC cytogenetic band: 7q33

CNOT4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CNOT4 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M135046:  view genomic region     (about GC identifiers)

Start:
135,046,547 bp from pter      End:
135,194,875 bp from pter
Size:
148,329 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 134,390,899-134,539,206     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: CNOT4_HUMAN, O95628 (See protein sequence)
Recommended Name: CCR4-NOT transcription complex subunit 4  
Size: 575 amino acids; 63510 Da
Subunit: Interacts with CNOT1 via its C-terminus but does not stably associate with the CCR4-NOT complex. Binds E2
ubiquitin ligases via its RING domain. Interacts (via RING domain) with UBE2D2
Sequence caution: Sequence=AAC72963.1; Type=Frameshift; Positions=Several; Sequence=AAC72963.1; Type=Miscellaneous
discrepancy; Note=Sequencing errors; Sequence=AAD00180.1; Type=Frameshift; Positions=358, 400;
Sequence=BAC11125.1; Type=Erroneous initiation;
2 PDB 3D structures from and Proteopedia for CNOT4:
1E4U (3D)        1UR6 (3D)    
Secondary accessions: B7Z6I4 E7ET38 F8VQP3 O95339 O95627 Q8IYM7 Q8NCL0 Q9NPQ1 Q9NZN6
Alternative splicing: 10 isoforms:  O95628-1   O95628-2   O95628-3   O95628-4   O95628-5   O95628-6   O95628-7   O95628-8   
O95628-9   O95628-10   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CNOT4: NX_O95628

Explore proteomics data for CNOT4 at MOPED

Post-translational modifications: 

  • Autoubiquitinated1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CNOT4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (6 alternative transcripts): 
    NP_001008226.1  NP_001177776.1  NP_001177777.1  NP_001177778.1  NP_001177779.1  NP_037448.2  

    ENSEMBL proteins: 
     ENSP00000388491   ENSP00000406777   ENSP00000354673   ENSP00000416532   ENSP00000399108  
     ENSP00000445508   ENSP00000348485   ENSP00000326731  
    Reactome Protein details: O95628

    CNOT4 Human Recombinant Protein Products:

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    Novus Biologicals CNOT4 Proteins
    Novus Biologicals CNOT4 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CNOT4

    CNOT4 Antibody Products:

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    CNOT4 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for CNOT4
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CNOT4
    Cloud-Clone Corp. CLIAs for CNOT4


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RBM: RNA binding motif (RRM) containing

    5 InterPro protein domains:
     IPR000571 Znf_CCCH
     IPR001841 Znf_RING
     IPR013083 Znf_RING/FYVE/PHD
     IPR012677 Nucleotide-bd_a/b_plait
     IPR000504 RRM_dom

    Graphical View of Domain Structure for InterPro Entry O95628

    ProtoNet protein and cluster: O95628

    2 Blocks protein domains:
    IPB000504 RNA-binding region RNP-1 (RNA recognition motif)
    IPB001841 Zn-finger


    UniProtKB/Swiss-Prot: CNOT4_HUMAN, O95628
    Similarity: Contains 1 C3H1-type zinc finger
    Similarity: Contains 1 RING-type zinc finger
    Similarity: Contains 1 RRM (RNA recognition motif) domain


    CNOT4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CNOT4_HUMAN, O95628
    Function: Has E3 ubiquitin ligase activity. Involved in activation of the JAK/STAT pathway

         Enzyme Number (IUBMB): EC 6.3.2.-1

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003676nucleic acid binding ----
    GO:0003723RNA binding ----
    GO:0004842ubiquitin-protein ligase activity IDA15001359
    GO:0005515protein binding IPI15001359
         
    CNOT4 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for CNOT4:
     Increased HPV18 LCR reporter a  Increased cell death HMECs cel 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CNOT4
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CNOT4
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CNOT4

    miRNA
    Products:
        
    miRTarBase miRNAs that target CNOT4:
    hsa-mir-93-5p (MIRT028102), hsa-mir-26b-5p (MIRT030177), hsa-mir-186-5p (MIRT021203), hsa-mir-19b-3p (MIRT031278), hsa-mir-130b-3p (MIRT020314), hsa-mir-98-5p (MIRT004947)

    Block miRNA regulation of human, mouse, rat CNOT4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CNOT4 (see all 18):
    hsa-miR-320a hsa-miR-429 hsa-miR-125a-3p hsa-miR-4263 hsa-miR-1205 hsa-miR-583 hsa-miR-511 hsa-miR-3658
    SwitchGear 3'UTR luciferase reporter plasmidCNOT4 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CNOT4
    Predesigned siRNA for gene silencing in human, mouse, rat CNOT4

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for CNOT4

    Clone
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    OriGene clones in human, mouse for CNOT4 (see all 28)
    OriGene ORF clones in mouse, rat for CNOT4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 6): CNOT4 (NM_001008225)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CNOT4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CNOT4

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for CNOT4 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CNOT4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CNOT4_HUMAN, O95628: Cytoplasm (Probable). Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus4
    extracellular1
    golgi apparatus1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005829cytosol TAS--
    GO:0030014colocalizes with CCR4-NOT complex IDA19558367

    CNOT4 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CNOT4 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Deadenylation-dependent mRNA decay
    Deadenylation-dependent mRNA decay0.48
    Deadenylation of mRNA0.48
    RNA degradation0.48
    2Gene Expression
    Gene Expression0.40

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for CNOT4
        Deadenylation of mRNA


    1 Kegg Pathway  (Kegg details for CNOT4):
        RNA degradation

    UniProtKB/Swiss-Prot: CNOT4_HUMAN, O95628
    Pathway: Protein modification; protein ubiquitination


    CNOT4 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including CNOT4: 

              Ubiquitin Ligases in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CNOT4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CNOT4 (O956283 ENSP000003546734) via UniProtKB, MINT, STRING, and/or I2D (see all 239)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CNOT1A5YKK63, ENSP000003209494STRING: ENSP00000320949 I2D: score=3 
    UBE2D2P628373, ENSP000003817174I2D: score=3 STRING: ENSP00000381717
    UBE2NP610883, ENSP000003161764I2D: score=2 STRING: ENSP00000316176
    MYCP011063, ENSP000003672074I2D: score=1 STRING: ENSP00000367207
    PABPC4Q133103, ENSP000003619494I2D: score=1 STRING: ENSP00000361949
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000288nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay TAS--
    GO:0000289nuclear-transcribed mRNA poly(A) tail shortening TAS--
    GO:0010467gene expression TAS--
    GO:0016070RNA metabolic process TAS--
    GO:0016071mRNA metabolic process TAS--

    CNOT4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CNOT4

    4 HMDB Compounds for CNOT4    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CNOT4 gene (6 alternative transcripts): 
    NM_001008225.2  NM_001190847.1  NM_001190848.1  NM_001190849.1  NM_001190850.1  NM_013316.3  

    Unigene Cluster for CNOT4:

    CCR4-NOT transcription complex, subunit 4
    Hs.490224  [show with all ESTs]
    Unigene Representative Sequence: BC035590
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000451834 ENST00000423368 ENST00000361528 ENST00000473470 ENST00000414802
    ENST00000428680 ENST00000491203 ENST00000498534 ENST00000465721 ENST00000541284(uc011kpy.2 uc011kpz.2 uc003vst.3 uc003vss.3)
    ENST00000356162 ENST00000315544(uc003vsv.2 uc003vsu.2)
    miRNA
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    Block miRNA regulation of human, mouse, rat CNOT4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CNOT4 (see all 18):
    hsa-miR-320a hsa-miR-429 hsa-miR-125a-3p hsa-miR-4263 hsa-miR-1205 hsa-miR-583 hsa-miR-511 hsa-miR-3658
    SwitchGear 3'UTR luciferase reporter plasmidCNOT4 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for CNOT4
    Predesigned siRNA for gene silencing in human, mouse, rat CNOT4
    Clone
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    OriGene clones in human, mouse for CNOT4 (see all 28)
    OriGene ORF clones in mouse, rat for CNOT4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 6): CNOT4 (NM_001008225)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CNOT4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CNOT4
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for CNOT4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CNOT4
      QuantiTect SYBR Green Assays in human, mouse, rat CNOT4
      QuantiFast Probe-based Assays in human, mouse, rat CNOT4

    Additional mRNA sequence: 

    AF091094.1 AF180475.1 AK055985.1 AK074493.1 AK074671.1 AK300365.1 AK314540.1 AL389980.1 
    BC035590.1 U71267.1 U71268.1 

    12 DOTS entries:

    DT.100773605  DT.306037  DT.444174  DT.95375780  DT.100024772  DT.91821036  DT.100707592  DT.75103110 
    DT.91988936  DT.95375778  DT.121100976  DT.121100979 

    Selected AceView cDNA sequences (see all 202):

    BQ441020 AW576246 BM472243 BP356904 AA286904 AI570510 BM803693 AI269845 
    BQ879075 BX472361 CA396599 CA771248 Z44319 BM838577 AW500197 BX952065 
    AA337514 BX478126 AL389980 AA337424 CR596624 BM825749 AI284731 BM929368 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CNOT4 (see all 11)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b · 17c
    SP1:                                                                                -                                                                     
    SP2:                                                                                                                                                      
    SP3:                                                                                                                                                      
    SP4:              -     -                                                                                                                                 
    SP5:                                                                                                                                                      


    ECgene alternative splicing isoforms for CNOT4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CNOT4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGGGAAAGCA
    CNOT4 Expression
    About this image

    CNOT4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CNOT4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.490224
        Pathway & Disease-focused RT2 Profiler PCR Array including CNOT4: 
              Ubiquitin Ligases in human mouse rat

    Primer
    Products:
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CNOT4
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    QuantiFast Probe-based Assays in human, mouse, rat CNOT4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CNOT4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for CNOT4 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cnot41 , 5 CCR4-NOT transcription complex, subunit 41, 5 94.65(n)1
    98.17(a)1
      6 (15.20 cM)5
    536211  NM_001164413.11  NP_001157885.11 
     350220665 
    chicken
    (Gallus gallus)
    Aves CNOT41 CCR4-NOT transcription complex, subunit 4 89.43(n)
    95.09(a)
      417936  NM_001012811.1  NP_001012829.1 
    lizard
    (Anolis carolinensis)
    Reptilia CNOT46
    CCR4-NOT transcription complex, subunit 4
    89(a)
    1 ↔ 1
    5(28085500-28160480)
    African clawed frog
    (Xenopus laevis)
    Amphibia cnot4-prov2 CCR4-NOT transcription complex, subunit 4 84.77(n)    BC044088.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc635662 similar to CCR4-NOT transcription complex, subunit more 78.33(n)   394144  BC054913.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Cnot46
    Cnot 4 homologue
    26(a)
    1 ↔ 1
    2L(10396716-10403206)
    worm
    (Caenorhabditis elegans)
    Secernentea C49H3.5a3 zinc-finger transcription regulator 56(a)     --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes MOT2(YER068W)4 Subunit of the CCR4-NOT complex, which has roles in more   --   5(293050-294813) 856799  NP_010991.1 


    ENSEMBL Gene Tree for CNOT4 (if available)
    TreeFam Gene Tree for CNOT4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CNOT4 gene

    CNOT4 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for CNOT4
    PGOHUM00000248317


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CNOT4 (see all 2895)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs675525181,2
    C--134453187(+) ACACA-/CACACACA
    CACACACACA
    TTTTT
    6 -- int11Minor allele frequency- CACACACACACACACACA:0.00NA 2
    rs1442226551,2
    --135046054(+) CCCCAC/TCAACA 4 -- ds50010--------
    rs69430401,2
    C,F,H--135046057(+) CATCAT/ACAGGT 4 -- ds500114Minor allele frequency- A:0.14NS EA NA CSA WA 651
    rs1900788641,2
    --135046146(+) GGCACA/TCACAA 4 -- ds50010--------
    rs624815691,2
    C,F--135046159(+) AGATGC/TCACTT 4 -- ds50018Minor allele frequency- T:0.34NA CSA WA EA 368
    rs1831424481,2
    --135046193(+) CTGCCA/GGGTCT 4 -- ds50010--------
    rs1477338461,2
    --135046308(+) GAGGAA/GTCTTC 4 -- ds50010--------
    rs10032261,2
    C,F,A,H--135046552(+) TGTCAC/TCATCA 4 -- ut3129Minor allele frequency- G:0.00NA EA NS CSA WA 2514
    rs1181550901,2
    F--135046584(+) TTTTAG/TTTTTA 4 -- ut311Minor allele frequency- T:0.02EA 120
    rs1877818421,2
    --135046729(+) GGCAAA/GGAGGT 4 -- ut310--------

    HapMap Linkage Disequilibrium report for CNOT4 (135046547 - 135194875 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for CNOT4 (see all 12):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2657378CNV Deletion23128226
    esv2735189CNV Deletion23290073
    esv2735188CNV Deletion23290073
    esv2735190CNV Deletion23290073
    esv2678090CNV Deletion23128226
    esv2442045CNV Deletion19546169
    esv2668392CNV Deletion23128226
    nsv5961CNV Insertion18451855
    nsv831146CNV Loss17160897
    dgv1135n67CNV Loss20364138

    Human Gene Mutation Database (HGMD): CNOT4
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CNOT4
    DNA2.0 Custom Variant and Variant Library Synthesis for CNOT4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604911    OMIM disorders: --

    1 disease for CNOT4:    About MalaCards
    choroiditis


    CNOT4 for disorders           About GeneDecksing

    Genetic Association Database (GAD): CNOT4
    Human Genome Epidemiology (HuGE) Navigator: CNOT4 (1 document)

    Export disorders for CNOT4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CNOT4 gene, integrated from 10 sources (see all 26):
    (articles sorted by number of sources associating them with CNOT4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation and characterization of human orthologs of yeast CCR4-NOT complex subunits. (PubMed id 10637334)1, 2, 3 Albert T.K....Timmers H.T.M. (Nucleic Acids Res. 2000)
    2. Not4 enhances JAK/STAT pathway-dependent gene expression in Drosophila and in human cells. (PubMed id 22159038)1, 2 Gronholm J.... Ramet M. (FASEB J. 2012)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. An altered-specificity ubiquitin-conjugating enzyme/ubiquitin-protein ligase pair. (PubMed id 15001359)1, 2 Winkler G.S....Timmers H.T. (J. Mol. Biol. 2004)
    7. Identification of a ubiquitin-protein ligase subunit within the CCR4- NOT transcription repressor complex. (PubMed id 11823428)1, 2 Albert T.K.... Timmers H.T.M. (EMBO J. 2002)
    8. The structure of the C4C4 ring finger of human NOT4 reveals features distinct from those of C3HC4 RING fingers. (PubMed id 11087754)1, 2 Hanzawa H.... Boelens R. (J. Biol. Chem. 2001)
    9. Structural model of the UbcH5B/CNOT4 complex revealed by combining NMR, mutagenesis, and docking approaches. (PubMed id 15062086)1, 9 Dominguez C....Boelens R. (Structure 2004)
    10. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4850 HGNC: 7880 AceView: CNOT4 Ensembl:ENSG00000080802 euGenes: HUgn4850
    ECgene: CNOT4 Kegg: 4850 H-InvDB: CNOT4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CNOT4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CNOT4 gene:
    Search GeneIP for patents involving CNOT4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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