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Aliases for CNOT4 Gene

Aliases for CNOT4 Gene

  • CCR4-NOT Transcription Complex, Subunit 4 2 3
  • NOT4 3 4 6
  • Potential Transcriptional Repressor NOT4Hp 3 4
  • E3 Ubiquitin-Protein Ligase CNOT4 3 4
  • CCR4-Associated Factor 4 3 4
  • NOT4 (Negative Regulator Of Transcription 4, Yeast) Homolog 3
  • CCR4-NOT Transcription Complex Subunit 4 3
  • EC 6.3.2.- 4
  • CLONE243 3
  • NOT4H 3

External Ids for CNOT4 Gene

Previous HGNC Symbols for CNOT4 Gene

  • NOT4

Previous GeneCards Identifiers for CNOT4 Gene

  • GC07M133389
  • GC07M134448
  • GC07M134462
  • GC07M134503
  • GC07M134697
  • GC07M135046
  • GC07M129349

Summaries for CNOT4 Gene

Entrez Gene Summary for CNOT4 Gene

  • The protein encoded by this gene is a subunit of the CCR4-NOT complex, a global transcriptional regulator. The encoded protein interacts with CNOT1 and has E3 ubiquitin ligase activity. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2010]

GeneCards Summary for CNOT4 Gene

CNOT4 (CCR4-NOT Transcription Complex, Subunit 4) is a Protein Coding gene. Among its related pathways are Gene Expression and Deadenylation-dependent mRNA decay. GO annotations related to this gene include RNA binding and ubiquitin-protein transferase activity.

UniProtKB/Swiss-Prot for CNOT4 Gene

  • Has E3 ubiquitin ligase activity. Involved in activation of the JAK/STAT pathway.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CNOT4 Gene

Genomics for CNOT4 Gene

Regulatory Elements for CNOT4 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CNOT4 Gene

135,361,795 bp from pter
135,510,127 bp from pter
148,333 bases
Minus strand

Genomic View for CNOT4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CNOT4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CNOT4 Gene

Proteins for CNOT4 Gene

  • Protein details for CNOT4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    CCR4-NOT transcription complex subunit 4
    Protein Accession:
    Secondary Accessions:
    • B7Z6I4
    • E7ET38
    • F8VQP3
    • O95339
    • O95627
    • Q8IYM7
    • Q8NCL0
    • Q9NPQ1
    • Q9NZN6

    Protein attributes for CNOT4 Gene

    575 amino acids
    Molecular mass:
    63510 Da
    Quaternary structure:
    • Interacts with CNOT1 via its C-terminus but does not stably associate with the CCR4-NOT complex. Binds E2 ubiquitin ligases via its RING domain. Interacts (via RING domain) with UBE2D2.
    • Sequence=AAC72963.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305}; Sequence=AAC72963.1; Type=Miscellaneous discrepancy; Note=Sequencing errors.; Evidence={ECO:0000305}; Sequence=AAD00180.1; Type=Frameshift; Positions=358, 400; Evidence={ECO:0000305}; Sequence=BAC11125.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CNOT4 Gene

    Alternative splice isoforms for CNOT4 Gene

neXtProt entry for CNOT4 Gene

Proteomics data for CNOT4 Gene at MOPED

Post-translational modifications for CNOT4 Gene

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for CNOT4

No data available for DME Specific Peptides for CNOT4 Gene

Domains for CNOT4 Gene

Suggested Antigen Peptide Sequences for CNOT4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 RRM (RNA recognition motif) domain.
  • Contains 1 C3H1-type zinc finger.
  • Contains 1 RRM (RNA recognition motif) domain.
  • Contains 1 C3H1-type zinc finger.
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with CNOT4: view

Function for CNOT4 Gene

Molecular function for CNOT4 Gene

UniProtKB/Swiss-Prot Function:
Has E3 ubiquitin ligase activity. Involved in activation of the JAK/STAT pathway.

Enzyme Numbers (IUBMB) for CNOT4 Gene

Gene Ontology (GO) - Molecular Function for CNOT4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding --
GO:0004842 ubiquitin-protein transferase activity IDA 15001359
GO:0005515 protein binding IPI 15001359
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with CNOT4: view

Phenotypes for CNOT4 Gene

genes like me logo Genes that share phenotypes with CNOT4: view

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CNOT4

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for CNOT4 Gene

Localization for CNOT4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CNOT4 Gene

Cytoplasm. Nucleus.

Subcellular locations from

Jensen Localization Image for CNOT4 Gene COMPARTMENTS Subcellular localization image for CNOT4 gene
Compartment Confidence
cytosol 4
nucleus 4
extracellular 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for CNOT4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005829 cytosol TAS --
GO:0030014 colocalizes_with CCR4-NOT complex IDA 19558367
genes like me logo Genes that share ontologies with CNOT4: view

Pathways for CNOT4 Gene

genes like me logo Genes that share pathways with CNOT4: view

Pathways by source for CNOT4 Gene

1 KEGG pathway for CNOT4 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

UniProtKB/Swiss-Prot O95628-CNOT4_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for CNOT4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay TAS --
GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening TAS --
GO:0010467 gene expression TAS --
GO:0016070 RNA metabolic process --
GO:0016071 mRNA metabolic process --
genes like me logo Genes that share ontologies with CNOT4: view

Drugs for CNOT4 Gene

(4) HMDB Compounds for CNOT4 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine monophosphate
  • 5'-Adenosine monophosphate
Adenosine triphosphate
  • 5'-(Tetrahydrogen triphosphate) Adenosine
Phosphoric acid
  • Acide phosphorique (FRENCH)
  • (4-)Diphosphoric acid ion
genes like me logo Genes that share compounds with CNOT4: view

Transcripts for CNOT4 Gene

Unigene Clusters for CNOT4 Gene

CCR4-NOT transcription complex, subunit 4:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CNOT4

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CNOT4 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b · 17c
SP1: -
SP4: - -
SP6: - -
SP8: - - -
SP9: -
SP11: - - -

Relevant External Links for CNOT4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CNOT4 Gene

mRNA expression in normal human tissues for CNOT4 Gene

Protein differential expression in normal tissues for CNOT4 Gene

This gene is overexpressed in Testis (41.9) and Frontal cortex (7.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CNOT4 Gene

SOURCE GeneReport for Unigene cluster for CNOT4 Gene Hs.490224

genes like me logo Genes that share expressions with CNOT4: view

Expression partners for CNOT4 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CNOT4 Gene

Orthologs for CNOT4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CNOT4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CNOT4 35
  • 95.48 (n)
  • 98.44 (a)
CNOT4 36
  • 97 (a)
(Canis familiaris)
Mammalia CNOT4 35
  • 97.05 (n)
  • 99.44 (a)
CNOT4 36
  • 99 (a)
(Mus musculus)
Mammalia Cnot4 35
  • 94.65 (n)
  • 98.17 (a)
Cnot4 16
Cnot4 36
  • 98 (a)
(Pan troglodytes)
Mammalia CNOT4 35
  • 99.76 (n)
  • 99.72 (a)
CNOT4 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Cnot4 35
  • 94.41 (n)
  • 97.75 (a)
(Monodelphis domestica)
Mammalia CNOT4 36
  • 97 (a)
(Ornithorhynchus anatinus)
Mammalia CNOT4 36
  • 96 (a)
(Gallus gallus)
Aves CNOT4 35
  • 89.43 (n)
  • 95.09 (a)
CNOT4 36
  • 89 (a)
(Anolis carolinensis)
Reptilia CNOT4 36
  • 89 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cnot4 35
  • 80.57 (n)
  • 89.69 (a)
African clawed frog
(Xenopus laevis)
Amphibia cnot4-prov 35
(Danio rerio)
Actinopterygii zgc63566 35
zgc:63566 35
  • 71.09 (n)
  • 76.6 (a)
CNOT4 (1 of 2) 36
  • 69 (a)
CNOT4 (2 of 2) 36
  • 67 (a)
fruit fly
(Drosophila melanogaster)
Insecta Cnot4 36
  • 26 (a)
(Caenorhabditis elegans)
Secernentea C49H3.5a 37
  • 56 (a)
ntl-4 36
  • 30 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MOT2 36
  • 30 (a)
MOT2 38
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.7897 35
Species with no ortholog for CNOT4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CNOT4 Gene

Gene Tree for CNOT4 (if available)
Gene Tree for CNOT4 (if available)

Paralogs for CNOT4 Gene Pseudogenes for CNOT4 Gene

genes like me logo Genes that share paralogs with CNOT4: view

No data available for Paralogs for CNOT4 Gene

Variants for CNOT4 Gene

Sequence variations from dbSNP and Humsavar for CNOT4 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs14469 -- 135,362,067(-) TTTTT(G/T)TTTTA utr-variant-3-prime
rs918874 -- 135,406,497(-) ttttt(G/T)gtaga intron-variant
rs918876 -- 135,471,381(-) CCTCA(G/T)ATTTT intron-variant
rs918877 -- 135,464,552(-) ccttc(C/T)accct intron-variant
rs997530 -- 135,369,395(-) CGGTA(A/G)GGGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CNOT4 Gene

Variant ID Type Subtype PubMed ID
esv29990 CNV Gain 17803354
nsv520786 CNV Gain 19592680
esv2735188 CNV Deletion 23290073
dgv1135n67 CNV Loss 20364138
esv2735189 CNV Deletion 23290073
esv2678090 CNV Deletion 23128226
esv2657378 CNV Deletion 23128226
nsv831146 CNV Loss 17160897
esv2442045 CNV Deletion 19546169
esv2735190 CNV Deletion 23290073
esv2668392 CNV Deletion 23128226
nsv5961 CNV Insertion 18451855

Relevant External Links for CNOT4 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CNOT4 Gene

Disorders for CNOT4 Gene

Relevant External Links for CNOT4

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for CNOT4 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for CNOT4 Gene

Publications for CNOT4 Gene

  1. Isolation and characterization of human orthologs of yeast CCR4-NOT complex subunits. (PMID: 10637334) Albert T.K. … Timmers H.T.M. (Nucleic Acids Res. 2000) 2 3 4
  2. Identification of a ubiquitin-protein ligase subunit within the CCR4- NOT transcription repressor complex. (PMID: 11823428) Albert T.K. … Timmers H.T.M. (EMBO J. 2002) 3 4
  3. Not4 enhances JAK/STAT pathway-dependent gene expression in Drosophila and in human cells. (PMID: 22159038) Gronholm J. … Ramet M. (FASEB J. 2012) 3 4
  4. An altered-specificity ubiquitin-conjugating enzyme/ubiquitin-protein ligase pair. (PMID: 15001359) Winkler G.S. … Timmers H.T. (J. Mol. Biol. 2004) 3 4
  5. The structure of the C4C4 ring finger of human NOT4 reveals features distinct from those of C3HC4 RING fingers. (PMID: 11087754) Hanzawa H. … Boelens R. (J. Biol. Chem. 2001) 3 4

Products for CNOT4 Gene

Sources for CNOT4 Gene

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