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Aliases for CNOT4 Gene

Aliases for CNOT4 Gene

  • CCR4-NOT Transcription Complex Subunit 4 2 3 5
  • Potential Transcriptional Repressor NOT4Hp 3 4
  • E3 Ubiquitin-Protein Ligase CNOT4 3 4
  • CCR4-Associated Factor 4 3 4
  • NOT4 3 4
  • NOT4 (Negative Regulator Of Transcription 4, Yeast) Homolog 3
  • CCR4-NOT Transcription Complex, Subunit 4 2
  • EC 6.3.2.- 4
  • CLONE243 3
  • NOT4H 3

External Ids for CNOT4 Gene

Previous HGNC Symbols for CNOT4 Gene

  • NOT4

Previous GeneCards Identifiers for CNOT4 Gene

  • GC07M133389
  • GC07M134448
  • GC07M134462
  • GC07M134503
  • GC07M134697
  • GC07M135046
  • GC07M129349

Summaries for CNOT4 Gene

Entrez Gene Summary for CNOT4 Gene

  • The protein encoded by this gene is a subunit of the CCR4-NOT complex, a global transcriptional regulator. The encoded protein interacts with CNOT1 and has E3 ubiquitin ligase activity. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2010]

GeneCards Summary for CNOT4 Gene

CNOT4 (CCR4-NOT Transcription Complex Subunit 4) is a Protein Coding gene. Diseases associated with CNOT4 include Adenoiditis. Among its related pathways are TP53 Regulates Transcription of Cell Cycle Genes and Deadenylation-dependent mRNA decay. GO annotations related to this gene include nucleic acid binding and nucleotide binding.

UniProtKB/Swiss-Prot for CNOT4 Gene

  • Has E3 ubiquitin ligase activity. Involved in activation of the JAK/STAT pathway.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CNOT4 Gene

Genomics for CNOT4 Gene

Regulatory Elements for CNOT4 Gene

Enhancers for CNOT4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07F135537 0.9 Ensembl ENCODE 12.3 -28.0 -27966 0.6 BCOR SMARCE1 HDAC1 RNF2 ARID1B ZNF318 IKZF1 IRF1 NR2F6 NR2C2 CNOT4 NUP205
GH07F135146 1 FANTOM5 ENCODE 4.3 +360.6 360577 6.6 HDGF PKNOX1 ARNT MLX SIN3A ARID4B YBX1 YY1 ZNF766 ZNF143 TMEM140 C7orf49 AGBL3 WDR91 CNOT4 PIR50393 GC07M135162
GH07F135978 1.5 FANTOM5 Ensembl ENCODE 4.2 -471.2 -471236 5.5 HDGF PKNOX1 ARNT CREB3L1 FEZF1 ZNF2 ZNF766 CBX5 KLF13 JUNB RNU6-1154P MTPN CNOT4 LUZP6 LOC105375523
GH07F135253 1.4 FANTOM5 Ensembl ENCODE 2.7 +255.6 255639 2.2 JUND MCM3 JUN SIN3A NFE2 ZIC2 SPI1 TCF7L2 NFE2L2 WDR91 STRA8 ENSG00000231794 TMEM140 CNOT4 GC07P135285
GH07F135158 1.4 FANTOM5 Ensembl ENCODE 2 +349.6 349636 4.6 PKNOX1 ARNT WRNIP1 ARID4B YY1 CBX5 FOS REST TBX21 MEF2D C7orf49 WDR91 TMEM140 CNOT4 GC07M135162 PIR50393
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around CNOT4 on UCSC Golden Path with GeneCards custom track

Promoters for CNOT4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for CNOT4 Gene

135,361,795 bp from pter
135,510,127 bp from pter
148,333 bases
Minus strand

Genomic View for CNOT4 Gene

Genes around CNOT4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CNOT4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CNOT4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CNOT4 Gene

Proteins for CNOT4 Gene

  • Protein details for CNOT4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    CCR4-NOT transcription complex subunit 4
    Protein Accession:
    Secondary Accessions:
    • B7Z6I4
    • E7ET38
    • F8VQP3
    • O95339
    • O95627
    • Q8IYM7
    • Q8NCL0
    • Q9NPQ1
    • Q9NZN6

    Protein attributes for CNOT4 Gene

    575 amino acids
    Molecular mass:
    63510 Da
    Quaternary structure:
    • Interacts with CNOT1 via its C-terminus but does not stably associate with the CCR4-NOT complex. Binds E2 ubiquitin ligases via its RING domain. Interacts (via RING domain) with UBE2D2.
    • Sequence=AAC72963.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305}; Sequence=AAC72963.1; Type=Miscellaneous discrepancy; Note=Sequencing errors.; Evidence={ECO:0000305}; Sequence=AAD00180.1; Type=Frameshift; Positions=358, 400; Evidence={ECO:0000305}; Sequence=BAC11125.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CNOT4 Gene

    Alternative splice isoforms for CNOT4 Gene

neXtProt entry for CNOT4 Gene

Post-translational modifications for CNOT4 Gene

Antibody Products

No data available for DME Specific Peptides for CNOT4 Gene

Domains & Families for CNOT4 Gene

Suggested Antigen Peptide Sequences for CNOT4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 RRM (RNA recognition motif) domain.
  • Contains 1 C3H1-type zinc finger.
  • Contains 1 RRM (RNA recognition motif) domain.
  • Contains 1 C3H1-type zinc finger.
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with CNOT4: view

Function for CNOT4 Gene

Molecular function for CNOT4 Gene

UniProtKB/Swiss-Prot Function:
Has E3 ubiquitin ligase activity. Involved in activation of the JAK/STAT pathway.

Enzyme Numbers (IUBMB) for CNOT4 Gene

Gene Ontology (GO) - Molecular Function for CNOT4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IEA --
GO:0004842 ubiquitin-protein transferase activity IDA 15001359
GO:0005515 protein binding IPI 15001359
genes like me logo Genes that share ontologies with CNOT4: view
genes like me logo Genes that share phenotypes with CNOT4: view

Animal Models for CNOT4 Gene

MGI Knock Outs for CNOT4:

Animal Model Products

miRNA for CNOT4 Gene

miRTarBase miRNAs that target CNOT4

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CNOT4 Gene

Localization for CNOT4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CNOT4 Gene

Cytoplasm. Nucleus.

Subcellular locations from

Jensen Localization Image for CNOT4 Gene COMPARTMENTS Subcellular localization image for CNOT4 gene
Compartment Confidence
cytosol 5
nucleus 5
extracellular 1
golgi apparatus 1
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CNOT4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0030014 colocalizes_with CCR4-NOT complex IDA 19558367
genes like me logo Genes that share ontologies with CNOT4: view

Pathways & Interactions for CNOT4 Gene

genes like me logo Genes that share pathways with CNOT4: view

UniProtKB/Swiss-Prot O95628-CNOT4_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for CNOT4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening TAS --
GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest TAS --
GO:0016567 protein ubiquitination IEA --
GO:0051865 protein autoubiquitination IDA 15001359
genes like me logo Genes that share ontologies with CNOT4: view

No data available for SIGNOR curated interactions for CNOT4 Gene

Drugs & Compounds for CNOT4 Gene

(3) Drugs for CNOT4 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Adenosine monophosphate Approved Nutra 0
Adenosine triphosphate Approved Nutra 0

(1) Additional Compounds for CNOT4 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • (4-)Diphosphoric acid ion
  • (P2O74-)Diphosphate
  • Diphosphate
  • Diphosphoric acid
  • PPi
genes like me logo Genes that share compounds with CNOT4: view

Transcripts for CNOT4 Gene

Unigene Clusters for CNOT4 Gene

CCR4-NOT transcription complex, subunit 4:
Representative Sequences:

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CNOT4 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b · 17c
SP1: -
SP4: - -
SP6: - -
SP8: - - -
SP9: -
SP11: - - -

Relevant External Links for CNOT4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CNOT4 Gene

mRNA expression in normal human tissues for CNOT4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CNOT4 Gene

This gene is overexpressed in Testis (41.9) and Frontal cortex (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CNOT4 Gene

Protein tissue co-expression partners for CNOT4 Gene

NURSA nuclear receptor signaling pathways regulating expression of CNOT4 Gene:


SOURCE GeneReport for Unigene cluster for CNOT4 Gene:

genes like me logo Genes that share expression patterns with CNOT4: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CNOT4 Gene

Orthologs for CNOT4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CNOT4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CNOT4 34 35
  • 99.76 (n)
(Canis familiaris)
Mammalia CNOT4 34 35
  • 97.05 (n)
(Monodelphis domestica)
Mammalia CNOT4 35
  • 97 (a)
(Ornithorhynchus anatinus)
Mammalia CNOT4 35
  • 96 (a)
(Bos Taurus)
Mammalia CNOT4 34 35
  • 95.48 (n)
(Mus musculus)
Mammalia Cnot4 34 16 35
  • 94.65 (n)
(Rattus norvegicus)
Mammalia Cnot4 34
  • 94.41 (n)
(Gallus gallus)
Aves CNOT4 34 35
  • 89.43 (n)
(Anolis carolinensis)
Reptilia CNOT4 35
  • 89 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cnot4 34
  • 80.57 (n)
African clawed frog
(Xenopus laevis)
Amphibia cnot4-prov 34
(Danio rerio)
Actinopterygii zgc:63566 34
  • 71.09 (n)
CNOT4 (1 of 2) 35
  • 69 (a)
CNOT4 (2 of 2) 35
  • 67 (a)
zgc63566 34
fruit fly
(Drosophila melanogaster)
Insecta Cnot4 35
  • 26 (a)
(Caenorhabditis elegans)
Secernentea C49H3.5a 36
  • 56 (a)
ntl-4 35
  • 30 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MOT2 35 37
  • 30 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.7897 34
Species where no ortholog for CNOT4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CNOT4 Gene

Gene Tree for CNOT4 (if available)
Gene Tree for CNOT4 (if available)

Paralogs for CNOT4 Gene Pseudogenes for CNOT4 Gene

genes like me logo Genes that share paralogs with CNOT4: view

No data available for Paralogs for CNOT4 Gene

Variants for CNOT4 Gene

Sequence variations from dbSNP and Humsavar for CNOT4 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1003226 -- 135,361,800(+) TGTCA(C/T)CATCA utr-variant-3-prime
rs10046574 -- 135,485,722(+) ggaag(C/T)gggac intron-variant
rs10085725 -- 135,479,590(+) aGAAT(C/T)TGACT intron-variant
rs10085728 -- 135,479,918(+) gaaTT(C/T)GAGAG intron-variant
rs10214966 -- 135,511,894(+) TGTAT(A/G)TATTA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CNOT4 Gene

Variant ID Type Subtype PubMed ID
dgv1135n67 CNV loss 20364138
dgv6637n100 CNV gain 25217958
esv2442045 CNV deletion 19546169
esv2657378 CNV deletion 23128226
esv2668392 CNV deletion 23128226
esv2678090 CNV deletion 23128226
esv2735188 CNV deletion 23290073
esv2735189 CNV deletion 23290073
esv2735190 CNV deletion 23290073
esv29990 CNV gain 17803354
esv3542471 CNV deletion 23714750
esv3542472 CNV deletion 23714750
esv3542473 CNV deletion 23714750
esv3615119 CNV loss 21293372
esv3615120 CNV gain 21293372
nsv1019101 CNV gain 25217958
nsv1075999 CNV deletion 25765185
nsv1121679 CNV deletion 24896259
nsv1124269 CNV deletion 24896259
nsv482983 CNV loss 15286789
nsv520786 CNV gain 19592680
nsv5961 CNV insertion 18451855
nsv608460 CNV gain 21841781
nsv608461 CNV loss 21841781
nsv831146 CNV loss 17160897
nsv955971 CNV deletion 24416366
nsv970944 CNV duplication 23825009

Variation tolerance for CNOT4 Gene

Residual Variation Intolerance Score: 24.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.29; 88.22% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CNOT4 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CNOT4 Gene

Disorders for CNOT4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CNOT4 Gene - From: DISEASES

Disorder Aliases PubMed IDs
  • chronic adenoiditis
- elite association - COSMIC cancer census association via MalaCards
Search CNOT4 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CNOT4

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with CNOT4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CNOT4 Gene

Publications for CNOT4 Gene

  1. Isolation and characterization of human orthologs of yeast CCR4-NOT complex subunits. (PMID: 10637334) Albert T.K. … Timmers H.T.M. (Nucleic Acids Res. 2000) 2 3 4 64
  2. Not4 enhances JAK/STAT pathway-dependent gene expression in Drosophila and in human cells. (PMID: 22159038) Gronholm J. … Ramet M. (FASEB J. 2012) 3 4 64
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. An altered-specificity ubiquitin-conjugating enzyme/ubiquitin-protein ligase pair. (PMID: 15001359) Winkler G.S. … Timmers H.T. (J. Mol. Biol. 2004) 3 4 64

Products for CNOT4 Gene

Sources for CNOT4 Gene

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