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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CNOT4 Gene

protein-coding   GIFtS: 61
GCID: GC07M135046

CCR4-NOT transcription complex, subunit 4


(Previous symbol: NOT4)
 Explore 2 diseases affiliated with
CNOT4 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CNOT4    

Aliases
for CNOT4 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
CCR4-NOT Transcription Complex, Subunit 41 2     CCR4-Associated Factor 42 3
NOT41 2 3 5     E3 Ubiquitin-Protein Ligase CNOT42 3
CLONE2431 2     CCR4-NOT Transcription Complex Subunit 42
NOT4H1 2     NOT4 (Negative Regulator Of Transcription 4, Yeast) Homolog2
Potential Transcriptional Repressor NOT4Hp2 3     EC 6.3.2.-3

External Ids:    HGNC: 78801   Entrez Gene: 48502   Ensembl: ENSG000000808027   OMIM: 6049115   UniProtKB: O956283   

Export aliases for CNOT4 gene to outside databases

Previous GC identifers: GC07M133389 GC07M134448 GC07M134462 GC07M134503 GC07M134697 GC07M129349


Summaries
for CNOT4 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CNOT4:
The protein encoded by this gene is a subunit of the CCR4-NOT complex, a global transcriptional regulator. The encoded
protein interacts with CNOT1 and has E3 ubiquitin ligase activity. Several transcript variants encoding different
isoforms have been found for this gene.(provided by RefSeq, Jul 2010)

UniProtKB/Swiss-Prot: CNOT4_HUMAN, O95628
Function: Has E3 ubiquitin ligase activity. The CCR4-NOT complex functions as general transcription regulation complex




Genomic Views
for CNOT4 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.1  NT_007933.15  NT_079596.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CNOT4 gene promoter:
         HOXA9   HOXA9B   GATA-3   GATA-2   GATA-1   Meis-1b   AREB6   HSF2   Pax-4a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): CNOT4 promoter sequence
   Search SABiosciences Chromatin IP Primers for CNOT4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CNOT4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q22-qter   Ensembl cytogenetic band:  7q33   HGNC cytogenetic band: 7q22-qter

CNOT4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CNOT4 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M135046:  view genomic region     (about GC identifiers)

Start:
 135,046,547 bp from pter      End:
 135,194,875 bp from pter
Size:
 148,329 bases      Orientation:
 minus strand

1 alternative location:
Chr7-,CRA_TCAG 134,390,899-134,539,206     

Proteins
for CNOT4 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CNOT4_HUMAN, O95628 (See protein sequence)
Recommended Name: CCR4-NOT transcription complex subunit 4  
Size: 575 amino acids; 63510 Da
Subunit: Subunit of the CCR4-NOT core complex that contains CHAF1A, CHAF1B, CNOT1, CNOT2, CNOT3, CNOT4, CNOT6 and
CNOT8. Binds CNOT1 via its C-terminus. Binds E2 ubiquitin ligases via its RING domain. Interacts (via RING domain)
with UBE2D2
Subcellular location: Cytoplasm (Probable). Nucleus (Probable)
Sequence caution: Sequence=AAC72963.1; Type=Frameshift; Positions=Several; Sequence=AAC72963.1; Type=Miscellaneous
discrepancy; Note=Sequencing errors; Sequence=AAD00180.1; Type=Frameshift; Positions=358, 400; Sequence=BAC11125.1;
Type=Erroneous initiation;
2 PDB 3D structures from and Proteopedia for CNOT4:
1E4U (3D)        1UR6 (3D)    
Secondary accessions: B7Z6I4 E7ET38 O95339 O95627 Q8IYM7 Q8NCL0 Q9NPQ1 Q9NZN6
Alternative splicing: 9 isoforms:  O95628-1   O95628-2   O95628-3   O95628-4   O95628-5   O95628-6   O95628-7   O95628-8   
O95628-9   (No experimental confirmation available. Ref.4 (BAH13270) sequence is in conflict in position: 545:V->I)

Explore the universe of human proteins at neXtProt for CNOT4: NX_O95628

Post-translational modifications:

  • Autoubiquitinated1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O95628

    • CNOT4 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (6 alternative transcripts): 
    NP_001008226.1  NP_001177776.1  NP_001177777.1  NP_001177778.1  NP_001177779.1  NP_037448.2  

    ENSEMBL proteins: 
     ENSP00000388491   ENSP00000406777   ENSP00000354673   ENSP00000416532   ENSP00000399108  
     ENSP00000445508   ENSP00000348485   ENSP00000326731  
    Reactome Protein details: O95628
    Human Recombinant Protein Products: 
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    OriGene Purified Protein: CNOT4
    OriGene Protein Over-expression Lysate (see all 2): CNOT4
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    GenScript Custom Purified and Recombinant Proteins Services for CNOT4
    Novus Biologicals CNOT4 Proteins
    Novus Biologicals CNOT4 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for CNOT4

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005829cytosol TAS--


    CNOT4 for ontologies           About GeneDecksing



    CNOT4 Antibody Products: 
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    Uscn ELISAs and CLIAs for CNOT4

    Protein Domains /
    Families
    for CNOT4 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CNOT4 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR000571 Znf_CCCH
     IPR001841 Znf_RING
     IPR013083 Znf_RING/FYVE/PHD
     IPR012677 Nucleotide-bd_a/b_plait
     IPR000504 RRM_dom

    Graphical View of Domain Structure for InterPro Entry O95628

    ProtoNet protein and cluster: O95628

    2 Blocks protein families:
    IPB000504 RNA-binding region RNP-1 (RNA recognition motif)
    IPB001841 Zn-finger


    UniProtKB/Swiss-Prot: CNOT4_HUMAN, O95628
    Similarity: Contains 1 C3H1-type zinc finger
    Similarity: Contains 1 RING-type zinc finger
    Similarity: Contains 1 RRM (RNA recognition motif) domain


    Function
    for CNOT4 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: CNOT4_HUMAN, O95628
    Function: Has E3 ubiquitin ligase activity. The CCR4-NOT complex functions as general transcription regulation complex

    Enzyme Number (IUBMB): EC 6.3.2.-1

    miRNA
    Products:            		miRTarBase miRNAs that target CNOT4:
    hsa-mir-98 (MIRT004947)

    OriGene 3'-UTR Clone (see all 2): CNOT4
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CNOT4
    8/18 QIAGEN miScript miRNA Assays for microRNAs that regulate CNOT4 (see all 18):
    hsa-miR-320a hsa-miR-429 hsa-miR-125a-3p hsa-miR-4263 hsa-miR-1205 hsa-miR-583 hsa-miR-511 hsa-miR-3658
    SwitchGear 3'UTR luciferase reporter plasmid: CNOT4 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CNOT4 (see all 7)
    OriGene shRNA RFP: CNOT4
    OriGene siRNA: CNOT4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CNOT4

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 6): CNOT4 (NM_001008225)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CNOT4 

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    Search LifeMap BioReagents cell lines for CNOT4

    In Situ Assay
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         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CNOT4

    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003723RNA binding IEA--
    GO:0004842ubiquitin-protein ligase activity IDA15001359
    GO:0005515protein binding IPI15001359
    GO:0008270zinc ion binding IEA--


    CNOT4 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for CNOT4:
     Increased HPV18 LCR reporter a  Increased cell death HMECs cel 


    Pathways & Interactions
    for CNOT4 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Deadenylation-dependent mRNA decay
    		Deadenylation-dependent mRNA decay1.00
    		Deadenylation of mRNA0.47
    		RNA degradation0.50
    2Metabolism of mRNA
    		Metabolism of mRNA1.00
    		Metabolism of RNA0.92
    3Generic Transcription Pathway
    		Gene Expression0.46

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    5        Reactome Pathways for CNOT4
        Deadenylation of mRNA
    Deadenylation-dependent mRNA decay
    Metabolism of RNA
    Metabolism of mRNA
    Gene Expression


    1         Kegg Pathway  (Kegg details for CNOT4):
        RNA degradation

    UniProtKB/Swiss-Prot: CNOT4_HUMAN, O95628
    Pathway: Protein modification; protein ubiquitination


    CNOT4 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CNOT4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/62 Interacting proteins for CNOT4 (O956283 ENSP000003546734) via UniProtKB, MINT, STRING, and/or I2D (see all 62)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    CNOT1A5YKK63, ENSP000003209494STRING: ENSP00000320949 I2D: score=3 
    UBE2D2P628373, ENSP000003817174I2D: score=3 STRING: ENSP00000381717
    UBE2D3P610773, ENSP000003497224I2D: score=2 STRING: ENSP00000349722
    UBE2NP610883, ENSP000003161764I2D: score=2 STRING: ENSP00000316176
    UBE2WQ96B023, ENSP000003974534I2D: score=2 STRING: ENSP00000397453
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000288nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay TAS--
    GO:0000289nuclear-transcribed mRNA poly(A) tail shortening TAS--
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--
    GO:0010467gene expression TAS--


    CNOT4 for ontologies           About GeneDecksing



    Drugs & Compounds
    for CNOT4 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CNOT4

    4 HMDB Compounds for CNOT4    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--
    Search CenterWatch for drugs/clinical trials and news about CNOT4 

    Transcripts
    for CNOT4 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CNOT4 gene (6 alternative transcripts): 
    NM_001008225.2  NM_001190847.1  NM_001190848.1  NM_001190849.1  NM_001190850.1  NM_013316.3  

    Unigene Cluster for CNOT4:

    CCR4-NOT transcription complex, subunit 4
    Hs.490224  [show with all ESTs]
    Unigene Representative Sequence: BC035590
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000451834 ENST00000423368 ENST00000361528 ENST00000473470 ENST00000414802
    ENST00000428680 ENST00000491203 ENST00000498534 ENST00000465721 ENST00000541284(uc011kpy.2 uc011kpz.2 uc003vst.3 uc003vss.3)
    ENST00000356162 ENST00000315544(uc003vsv.2 uc003vsu.2)

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CNOT4
    8/18 QIAGEN miScript miRNA Assays for microRNAs that regulate CNOT4 (see all 18):
    hsa-miR-320a hsa-miR-429 hsa-miR-125a-3p hsa-miR-4263 hsa-miR-1205 hsa-miR-583 hsa-miR-511 hsa-miR-3658
    SwitchGear 3'UTR luciferase reporter plasmid: CNOT4 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CNOT4 (see all 7)
    OriGene shRNA RFP: CNOT4
    OriGene siRNA: CNOT4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CNOT4
    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 6): CNOT4 (NM_001008225)
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    Primer
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    Additional cDNA sequence: 

    AF091094.1 AF180475.1 AK055985.1 AK074493.1 AK074671.1 AK300365.1 AK314540.1 AL389980.1 
    BC035590.1 U71267.1 U71268.1 

    13 DOTS entries:

    DT.100773605  DT.306037  DT.444174  DT.95375780  DT.100024772  DT.91821036  DT.100707592  DT.75103110 
    DT.91988936  DT.95375778  DT.121100976  DT.121100979  DT.86854927 

    24/202 AceView cDNA sequences (see all 202):

    AW500197 BM803693 BP356904 CA771248 BM472243 AA286904 BX952065 BQ441020 
    AA337514 AW303275 BM825749 CR596624 BM929368 BX472361 BM694746 CA396599 
    AI284731 AW576246 BM838577 BX478126 AA337424 AL389980 AI570510 AI269845 

    GeneLoc Exon Structure

    5/11 Alternative Splicing Database (ASD) splice patterns (SP) for CNOT4 (see all 11)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b · 17c
    SP1:                                                                                -                                                                     
    SP2:                                                                                                                                                      
    SP3:                                                                                                                                                      
    SP4:              -     -                                                                                                                                 
    SP5:                                                                                                                                                      


    ECgene alternative splicing isoforms for CNOT4

    Expression
    for CNOT4 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CNOT4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GGGGAAAGCA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See CNOT4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CNOT4

    SOURCE GeneReport for Unigene cluster: Hs.490224
        SABiosciences Expression via Pathway-Focused PCR Array including CNOT4: 
              Ubiquitin Ligases in human mouse rat

    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CNOT4

    Orthologs
    for CNOT4 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CNOT4 gene from 9/25 species (see all 25)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Cnot41 , 5 CCR4-NOT transcription complex, subunit 41, 5 94.69(n)1
    98.31(a)1    		   6 (15.20 cM)5
    536211  NM_001164413.11  NP_001157885.11 
     350220665 
    chicken
    (Gallus gallus)    		 Aves CNOT41 CCR4-NOT transcription complex, subunit 4 89.25(n)
    94.65(a)    		   417936  NM_001012811.1  NP_001012829.1 
    lizard
    (Anolis carolinensis)    		 Reptilia CNOT46
    		 --
    		 89(a)
    		 1 ↔ 1
    		 5(28086712-28139344)
    African clawed frog
    (Xenopus laevis)    		 Amphibia cnot4-prov2 CCR4-NOT transcription complex, subunit 4 84.77(n)    BC044088.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii zgc635662 similar to CCR4-NOT transcription complex, subunit more 78.33(n)   394144  BC054913.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Cnot46
    		 Cnot 4 homologue
    		 21(a)
    		 1 ↔ 1
    		 2L(10396716-10403206)
    worm
    (Caenorhabditis elegans)    		 Secernentea C49H3.5a3 zinc-finger transcription regulator 56(a)     --
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT2G285406
    AT3G456306
    (see all 3)    		 CCR4-NOT transcription complex subunit 4
    (see all 3)    		 14(a)
    14(a)
    (see all 3)    		 many → 1
    many → 1
    (see all 3)    		 2(12218045-12223828)
    3(16748174-16753833)
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    (see all 3)    		 expressed protein
    (see all 3)    		 15(a)
    13(a)
    (see all 3)    		 many → 1
    many → 1
    (see all 3)    		 1(5944633-5953387)
    11(109158-115986)


    ENSEMBL Gene Tree for CNOT4 (if available)
    TreeFam Gene Tree for CNOT4 (if available) 

    Paralogs
    for CNOT4 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CNOT4 gene

    CNOT4 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for CNOT4
    PGOHUM00000248317


    Genomic Variants
    for CNOT4 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2496 NCBI SNPs in CNOT4 are shown (see all 2496)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 7 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1442226551,2
    		--135046054(+) CCCCAC/TCAACA 4 -- ds50010--------
    rs69430401,2
    		C,F,H,--135046057(+) CATCAT/ACAGGT 4 -- ds500114Minor allele frequency- A:0.14NS EA NA CSA WA 651
    rs1900788641,2
    		--135046146(+) GGCACA/TCACAA 4 -- ds50010--------
    rs624815691,2
    		C,F,--135046159(+) AGATGC/TCACTT 4 -- ds50018Minor allele frequency- T:0.34NA CSA WA EA 368
    rs1831424481,2
    		--135046193(+) CTGCCA/GGGTCT 4 -- ds50010--------
    rs1477338461,2
    		--135046308(+) GAGGAA/GTCTTC 4 -- ds50010--------
    rs10032261,2
    		C,F,A,H,--135046552(+) TGTCAC/TCATCA 4 -- ut3129Minor allele frequency- G:0.00NA EA NS CSA WA 2514
    rs1181550901,2
    		F,--135046584(+) TTTTAG/TTTTTA 4 -- ut311Minor allele frequency- T:0.02EA 120
    rs1877818421,2
    		--135046729(+) GGCAAA/GGAGGT 4 -- ut310--------
    rs1922120011,2
    		--135046733(+) AGGAGA/GTCAGA 4 -- ut310--------

    HapMap Linkage Disequilibrium report for CNOT4 (135046547 - 135194875 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for CNOT4
         2 CNVs: 36621 100131
    Human Gene Mutation Database (HGMD): CNOT4

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CNOT4
    DNA2.0 Custom Variant and Variant Library Synthesis for CNOT4

    Disorders / Diseases
    for CNOT4 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CNOT4 for disorders           About GeneDecksing

    OMIM gene information: 604911    OMIM disorders: --

    2 diseases for CNOT4:    About MalaCards
    choroiditis    malaria

    Human Genome Epidemiology (HuGE) Navigator: CNOT4 (1 document)

    Export disorders for CNOT4 gene to outside databases

    Publications
    for CNOT4 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CNOT4 gene, integrated from 9 sources (see all 24):
    (articles sorted by number of sources associating them with CNOT4)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation and characterization of human orthologs of yeast CCR4-NOT complex subunits. (PubMed id 10637334)1, 2, 3 Albert T.K....Timmers H.T. (2000)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. An altered-specificity ubiquitin-conjugating enzyme/ubiquitin-protein ligase pair. (PubMed id 15001359)1, 2 Winkler G.S....Timmers H.T. (2004)
    5. Identification of a ubiquitin-protein ligase subunit within the CCR4- NOT transcription repressor complex. (PubMed id 11823428)1, 2 Albert T.K.... Timmers H.T.M. (2002)
    6. The structure of the C4C4 ring finger of human NOT4 reveals features distinct from those of C3HC4 RING fingers. (PubMed id 11087754)1, 2 Hanzawa H.... Boelens R. (2001)
    7. Structural model of the UbcH5B/CNOT4 complex revealed by combining NMR, mutagenesis, and docking approaches. (PubMed id 15062086)1, 9 Dominguez C....Boelens R. (2004)
    8. Not4 enhances JAK/STAT pathway-dependent gene expressi on in Drosophila and in human cells. (PubMed id 22159038)1 Gronholm J....Ramet M. (2012)
    9. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    10. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)

    External Searches for CNOT4 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing CNOT4 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4850 HGNC: 7880 AceView: CNOT4 Ensembl:ENSG00000080802 euGenes: HUgn4850
    ECgene: CNOT4 Kegg: 4850 H-InvDB: CNOT4

    Other Databases showing CNOT4 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CNOT4 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CNOT4 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for CNOT4 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CNOT4 gene:
    Search GeneIP for patents involving CNOT4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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