Aliases for CNOT3 Gene
External Ids for CNOT3 Gene
Previous HGNC Symbols for CNOT3 Gene
Previous GeneCards Identifiers for CNOT3 Gene
GeneCards Summary for CNOT3 Gene
CNOT3 (CCR4-NOT Transcription Complex Subunit 3) is a Protein Coding gene. Diseases associated with CNOT3 include precursor t-cell acute lymphoblastic leukemia and retinitis pigmentosa. Among its related pathways are Gene Expression and Regulation of TP53 Activity.
UniProtKB/Swiss-Prot for CNOT3 Gene
Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. May be involved in metabolic regulation; may be involved in recruitment of the CCR4-NOT complex to deadenylation target mRNAs involved in energy metabolism. Involved in mitotic progression and regulation of the spindle assembly checkpoint by regulating the stability of MAD1L1 mRNA. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may involve histone deacetylases. Involved in the maintenance of emryonic stem (ES) cell identity.