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Aliases for CNOT3 Gene

Aliases for CNOT3 Gene

  • CCR4-NOT Transcription Complex, Subunit 3 2 3
  • NOT3 3 4 6
  • Leukocyte Receptor Cluster Member 2 3 4
  • CCR4-Associated Factor 3 3 4
  • LENG2 3 4
  • NOT3 (Negative Regulator Of Transcription 3, Yeast) Homolog 3
  • NOT3 (Negative Regulator Of Transcription 3 2
  • CCR4-NOT Transcription Complex Subunit 3 3
  • Yeast) Homolog 2
  • KIAA0691 4
  • NOT3H 3

External Ids for CNOT3 Gene

Previous HGNC Symbols for CNOT3 Gene

  • NOT3

Previous GeneCards Identifiers for CNOT3 Gene

  • GC19P055290
  • GC19P055066
  • GC19P059318
  • GC19P059333
  • GC19P054641
  • GC19P050957

Summaries for CNOT3 Gene

GeneCards Summary for CNOT3 Gene

CNOT3 (CCR4-NOT Transcription Complex, Subunit 3) is a Protein Coding gene. Diseases associated with CNOT3 include precursor t-cell acute lymphoblastic leukemia. Among its related pathways are Gene Expression and Deadenylation-dependent mRNA decay.

UniProtKB/Swiss-Prot for CNOT3 Gene

  • Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. May be involved in metabolic regulation; may be involved in recruitment of the CCR4-NOT complex to deadenylation target mRNAs involved in energy metabolism. Involved in mitotic progression and regulation of the spindle assembly checkpoint by regulating the stability of MAD1L1 mRNA. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may involve histone deacetylases. Involved in the maintenance of emryonic stem (ES) cell identity.

Gene Wiki entry for CNOT3 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CNOT3 Gene

Genomics for CNOT3 Gene

Regulatory Elements for CNOT3 Gene

Genomic Location for CNOT3 Gene

Start:
54,137,720 bp from pter
End:
54,155,708 bp from pter
Size:
17,989 bases
Orientation:
Plus strand

Genomic View for CNOT3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CNOT3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CNOT3 Gene

Proteins for CNOT3 Gene

  • Protein details for CNOT3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75175-CNOT3_HUMAN
    Recommended name:
    CCR4-NOT transcription complex subunit 3
    Protein Accession:
    O75175
    Secondary Accessions:
    • Q9NZN7
    • Q9UF76

    Protein attributes for CNOT3 Gene

    Size:
    753 amino acids
    Molecular mass:
    81872 Da
    Quaternary structure:
    • Component of the CCR4-NOT complex; distinct complexes seem to exist that differ in the participation of probably mutually exclusive catalytic subunits. In the complex interacts directly with CNOT2. Interacts with TIP120B and NANOS2.
    SequenceCaution:
    • Sequence=BAA31666.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CNOT3 Gene

    Alternative splice isoforms for CNOT3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CNOT3 Gene

Proteomics data for CNOT3 Gene at MOPED

Post-translational modifications for CNOT3 Gene

  • Ubiquitination at Lys737
  • Modification sites at PhosphoSitePlus

Other Protein References for CNOT3 Gene

No data available for DME Specific Peptides for CNOT3 Gene

Domains for CNOT3 Gene

Protein Domains for CNOT3 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

O75175

UniProtKB/Swiss-Prot:

CNOT3_HUMAN :
  • O75175
Family:
  • Belongs to the CNOT2/3/5 family.
genes like me logo Genes that share domains with CNOT3: view

No data available for Gene Families for CNOT3 Gene

Function for CNOT3 Gene

Molecular function for CNOT3 Gene

UniProtKB/Swiss-Prot Function: Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. May be involved in metabolic regulation; may be involved in recruitment of the CCR4-NOT complex to deadenylation target mRNAs involved in energy metabolism. Involved in mitotic progression and regulation of the spindle assembly checkpoint by regulating the stability of MAD1L1 mRNA. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may involve histone deacetylases. Involved in the maintenance of emryonic stem (ES) cell identity.

Gene Ontology (GO) - Molecular Function for CNOT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 10637334
genes like me logo Genes that share ontologies with CNOT3: view

Phenotypes for CNOT3 Gene

genes like me logo Genes that share phenotypes with CNOT3: view

Animal Models for CNOT3 Gene

MGI Knock Outs for CNOT3:

miRNA for CNOT3 Gene

miRTarBase miRNAs that target CNOT3

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for CNOT3 Gene

Localization for CNOT3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CNOT3 Gene

Cytoplasm. Nucleus. Cytoplasm, P-body. Note=NANOS2 promotes its localization to P-body. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CNOT3 Gene COMPARTMENTS Subcellular localization image for CNOT3 gene
Compartment Confidence
cytosol 4
nucleus 4

Gene Ontology (GO) - Cellular Components for CNOT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000932 cytoplasmic mRNA processing body ISS --
GO:0005634 nucleus IEA --
GO:0005829 cytosol TAS --
GO:0030014 CCR4-NOT complex IDA 19558367
genes like me logo Genes that share ontologies with CNOT3: view

Pathways for CNOT3 Gene

genes like me logo Genes that share pathways with CNOT3: view

Pathways by source for CNOT3 Gene

1 KEGG pathway for CNOT3 Gene

Gene Ontology (GO) - Biological Process for CNOT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay TAS --
GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening TAS --
GO:0001829 trophectodermal cell differentiation IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with CNOT3: view

Transcripts for CNOT3 Gene

Unigene Clusters for CNOT3 Gene

CCR4-NOT transcription complex, subunit 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CNOT3 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a ·
SP1: -
SP2: -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

ExUns: 19b ^ 20
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for CNOT3 Gene

GeneLoc Exon Structure for
CNOT3
ECgene alternative splicing isoforms for
CNOT3

Expression for CNOT3 Gene

mRNA expression in normal human tissues for CNOT3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CNOT3 Gene

SOURCE GeneReport for Unigene cluster for CNOT3 Gene Hs.343571

mRNA Expression by UniProt/SwissProt for CNOT3 Gene

O75175-CNOT3_HUMAN
Tissue specificity: Ubiquitous. Highly expressed in brain, heart, thymus, spleen, kidney, liver, small intestine, lung and peripheral blood leukocytes.
genes like me logo Genes that share expressions with CNOT3: view

No data available for mRNA differential expression in normal tissues for CNOT3 Gene

Orthologs for CNOT3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CNOT3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CNOT3 35
  • 99.51 (n)
  • 100 (a)
CNOT3 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CNOT3 35
  • 90.64 (n)
  • 94.89 (a)
CNOT3 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CNOT3 35
  • 91.28 (n)
  • 96.81 (a)
CNOT3 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cnot3 35
  • 90.95 (n)
  • 95.07 (a)
Cnot3 16
Cnot3 36
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CNOT3 36
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cnot3 35
  • 90.68 (n)
  • 95.34 (a)
lizard
(Anolis carolinensis)
Reptilia CNOT3 36
  • 85 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.33620 35
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100158546 35
  • 71.22 (n)
  • 81.62 (a)
zebrafish
(Danio rerio)
Actinopterygii -- 35
cnot3a 35
  • 70.56 (n)
  • 79.17 (a)
cnot3a 36
  • 57 (a)
OneToMany
cnot3b 36
  • 51 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta l(2)NC136 36
  • 40 (a)
OneToOne
CG8426 37
  • 64 (a)
worm
(Caenorhabditis elegans)
Secernentea ntl-3 36
  • 38 (a)
OneToOne
Y56A3A.1 37
  • 43 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NOT3 36
  • 22 (a)
OneToOne
NOT3 38
rice
(Oryza sativa)
Liliopsida Os.8777 35
wheat
(Triticum aestivum)
Liliopsida Ta.14014 35
Species with no ortholog for CNOT3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for CNOT3 Gene

ENSEMBL:
Gene Tree for CNOT3 (if available)
TreeFam:
Gene Tree for CNOT3 (if available)

Paralogs for CNOT3 Gene

Selected SIMAP similar genes for CNOT3 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with CNOT3: view

No data available for Paralogs for CNOT3 Gene

Variants for CNOT3 Gene

Sequence variations from dbSNP and Humsavar for CNOT3 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs11606 -- 54,154,365(+) CCAGT(C/G)CAGCT intron-variant
rs36632 -- 54,144,350(+) GACCC(A/G)ACACC intron-variant
rs36633 -- 54,142,554(-) CTGGA(A/G)ATCAC intron-variant
rs36634 -- 54,142,105(+) CCTCC(A/G)TGAGT intron-variant
rs36635 -- 54,141,434(-) GCCCA(C/T)AAAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CNOT3 Gene

Variant ID Type Subtype PubMed ID
esv2718812 CNV Deletion 23290073
dgv4001n71 CNV Loss 21882294
nsv515623 CNV Loss 19592680
dgv4002n71 CNV Loss 21882294
nsv2545 CNV Insertion 18451855
esv24700 CNV Loss 19812545
nsv912398 CNV Loss 21882294

Relevant External Links for CNOT3 Gene

HapMap Linkage Disequilibrium report
CNOT3
Human Gene Mutation Database (HGMD)
CNOT3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CNOT3 Gene

Disorders for CNOT3 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for CNOT3 Gene including...

Search for CNOT3 Gene in MalaCards »

Relevant External Links for CNOT3

Human Genome Epidemiology (HuGE) Navigator
CNOT3
genes like me logo Genes that share disorders with CNOT3: view

No data available for UniProtKB/Swiss-Prot for CNOT3 Gene

Publications for CNOT3 Gene

  1. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9734811) Ishikawa K. … Ohara O. (DNA Res. 1998) 2 3 4
  2. Isolation and characterization of human orthologs of yeast CCR4-NOT complex subunits. (PMID: 10637334) Albert T.K. … Timmers H.T.M. (Nucleic Acids Res. 2000) 2 3 4
  3. TBP-interacting protein 120B, which is induced in relation to myogenesis, binds to NOT3. (PMID: 12207886) Aoki T. … Tamura T.-A. (Biochem. Biophys. Res. Commun. 2002) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Human Ccr4-Not complexes contain variable deadenylase subunits. (PMID: 19558367) Lau N.C. … Timmers H.T. (Biochem. J. 2009) 3 4

Products for CNOT3 Gene

  • Addgene plasmids for CNOT3

Sources for CNOT3 Gene

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