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Aliases for CNOT3 Gene

Aliases for CNOT3 Gene

  • CCR4-NOT Transcription Complex Subunit 3 2 3 5
  • CCR4-NOT Transcription Complex, Subunit 3 2 3
  • Leukocyte Receptor Cluster Member 2 3 4
  • CCR4-Associated Factor 3 3 4
  • LENG2 3 4
  • NOT3 3 4
  • NOT3 (Negative Regulator Of Transcription 3, Yeast) Homolog 3
  • NOT3 (Negative Regulator Of Transcription 3 2
  • Yeast) Homolog 2
  • KIAA0691 4
  • NOT3H 3

External Ids for CNOT3 Gene

Previous HGNC Symbols for CNOT3 Gene

  • NOT3

Previous GeneCards Identifiers for CNOT3 Gene

  • GC19P055290
  • GC19P055066
  • GC19P059318
  • GC19P059333
  • GC19P054641
  • GC19P050957

Summaries for CNOT3 Gene

GeneCards Summary for CNOT3 Gene

CNOT3 (CCR4-NOT Transcription Complex Subunit 3) is a Protein Coding gene. Diseases associated with CNOT3 include precursor t-cell acute lymphoblastic leukemia and retinitis pigmentosa. Among its related pathways are Gene Expression and Regulation of TP53 Activity.

UniProtKB/Swiss-Prot for CNOT3 Gene

  • Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. May be involved in metabolic regulation; may be involved in recruitment of the CCR4-NOT complex to deadenylation target mRNAs involved in energy metabolism. Involved in mitotic progression and regulation of the spindle assembly checkpoint by regulating the stability of MAD1L1 mRNA. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may involve histone deacetylases. Involved in the maintenance of emryonic stem (ES) cell identity.

Gene Wiki entry for CNOT3 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CNOT3 Gene

Genomics for CNOT3 Gene

Regulatory Elements for CNOT3 Gene

Promoters for CNOT3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CNOT3 on UCSC Golden Path with GeneCards custom track

Genomic Location for CNOT3 Gene

Chromosome:
19
Start:
54,137,689 bp from pter
End:
54,155,708 bp from pter
Size:
18,020 bases
Orientation:
Plus strand

Genomic View for CNOT3 Gene

Genes around CNOT3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CNOT3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CNOT3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CNOT3 Gene

Proteins for CNOT3 Gene

  • Protein details for CNOT3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75175-CNOT3_HUMAN
    Recommended name:
    CCR4-NOT transcription complex subunit 3
    Protein Accession:
    O75175
    Secondary Accessions:
    • Q9NZN7
    • Q9UF76

    Protein attributes for CNOT3 Gene

    Size:
    753 amino acids
    Molecular mass:
    81872 Da
    Quaternary structure:
    • Component of the CCR4-NOT complex; distinct complexes seem to exist that differ in the participation of probably mutually exclusive catalytic subunits. In the complex interacts directly with CNOT2. Interacts with TIP120B and NANOS2.
    SequenceCaution:
    • Sequence=BAA31666.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CNOT3 Gene

    Alternative splice isoforms for CNOT3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CNOT3 Gene

Proteomics data for CNOT3 Gene at MOPED

Post-translational modifications for CNOT3 Gene

  • Ubiquitination at Lys 737
  • Modification sites at PhosphoSitePlus

Other Protein References for CNOT3 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CNOT3 (NOT3)

No data available for DME Specific Peptides for CNOT3 Gene

Domains & Families for CNOT3 Gene

Gene Families for CNOT3 Gene

Protein Domains for CNOT3 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

O75175

UniProtKB/Swiss-Prot:

CNOT3_HUMAN :
  • Belongs to the CNOT2/3/5 family.
Family:
  • Belongs to the CNOT2/3/5 family.
genes like me logo Genes that share domains with CNOT3: view

Function for CNOT3 Gene

Molecular function for CNOT3 Gene

UniProtKB/Swiss-Prot Function:
Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. May be involved in metabolic regulation; may be involved in recruitment of the CCR4-NOT complex to deadenylation target mRNAs involved in energy metabolism. Involved in mitotic progression and regulation of the spindle assembly checkpoint by regulating the stability of MAD1L1 mRNA. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may involve histone deacetylases. Involved in the maintenance of emryonic stem (ES) cell identity.
genes like me logo Genes that share phenotypes with CNOT3: view

Animal Models for CNOT3 Gene

MGI Knock Outs for CNOT3:

Animal Model Products

miRNA for CNOT3 Gene

miRTarBase miRNAs that target CNOT3

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CNOT3 Gene

Localization for CNOT3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CNOT3 Gene

Cytoplasm. Nucleus. Cytoplasm, P-body. Note=NANOS2 promotes its localization to P-body. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CNOT3 Gene COMPARTMENTS Subcellular localization image for CNOT3 gene
Compartment Confidence
cytosol 4
nucleus 3

No data available for Gene Ontology (GO) - Cellular Components for CNOT3 Gene

Pathways & Interactions for CNOT3 Gene

genes like me logo Genes that share pathways with CNOT3: view

SIGNOR curated interactions for CNOT3 Gene

Other effect:

Gene Ontology (GO) - Biological Process for CNOT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IBA --
GO:0001829 trophectodermal cell differentiation IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0010467 gene expression TAS --
GO:0031047 gene silencing by RNA IEA --
genes like me logo Genes that share ontologies with CNOT3: view

Drugs & Compounds for CNOT3 Gene

No Compound Related Data Available

Transcripts for CNOT3 Gene

Unigene Clusters for CNOT3 Gene

CCR4-NOT transcription complex, subunit 3:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CNOT3 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a ·
SP1: -
SP2: -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

ExUns: 19b ^ 20
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for CNOT3 Gene

GeneLoc Exon Structure for
CNOT3
ECgene alternative splicing isoforms for
CNOT3

Expression for CNOT3 Gene

mRNA expression in normal human tissues for CNOT3 Gene

Protein differential expression in normal tissues from HIPED for CNOT3 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (8.9) and CD8 Tcells (8.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CNOT3 Gene



SOURCE GeneReport for Unigene cluster for CNOT3 Gene Hs.343571

mRNA Expression by UniProt/SwissProt for CNOT3 Gene

O75175-CNOT3_HUMAN
Tissue specificity: Ubiquitous. Highly expressed in brain, heart, thymus, spleen, kidney, liver, small intestine, lung and peripheral blood leukocytes.
genes like me logo Genes that share expression patterns with CNOT3: view

Protein tissue co-expression partners for CNOT3 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for CNOT3 Gene

Orthologs for CNOT3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CNOT3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CNOT3 35
  • 90.64 (n)
  • 94.89 (a)
CNOT3 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CNOT3 35
  • 91.28 (n)
  • 96.81 (a)
CNOT3 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cnot3 35
  • 90.95 (n)
  • 95.07 (a)
Cnot3 16
Cnot3 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CNOT3 35
  • 99.51 (n)
  • 100 (a)
CNOT3 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cnot3 35
  • 90.68 (n)
  • 95.34 (a)
oppossum
(Monodelphis domestica)
Mammalia CNOT3 36
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CNOT3 36
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100158546 35
  • 71.22 (n)
  • 81.62 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.33620 35
zebrafish
(Danio rerio)
Actinopterygii -- 35
cnot3a 35
  • 70.56 (n)
  • 79.17 (a)
cnot3a 36
  • 57 (a)
OneToMany
cnot3b 36
  • 51 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG8426 37
  • 64 (a)
l(2)NC136 36
  • 40 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea Y56A3A.1 37
  • 43 (a)
ntl-3 36
  • 38 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NOT3 36
  • 22 (a)
OneToOne
NOT3 38
rice
(Oryza sativa)
Liliopsida Os.8777 35
wheat
(Triticum aestivum)
Liliopsida Ta.14014 35
Species with no ortholog for CNOT3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for CNOT3 Gene

ENSEMBL:
Gene Tree for CNOT3 (if available)
TreeFam:
Gene Tree for CNOT3 (if available)

Paralogs for CNOT3 Gene

(1) SIMAP similar genes for CNOT3 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with CNOT3: view

No data available for Paralogs for CNOT3 Gene

Variants for CNOT3 Gene

Structural Variations from Database of Genomic Variants (DGV) for CNOT3 Gene

Variant ID Type Subtype PubMed ID
esv2718812 CNV Deletion 23290073
dgv4001n71 CNV Loss 21882294
nsv515623 CNV Loss 19592680
dgv4002n71 CNV Loss 21882294
nsv2545 CNV Insertion 18451855
esv24700 CNV Loss 19812545
nsv912398 CNV Loss 21882294

Variation tolerance for CNOT3 Gene

Residual Variation Intolerance Score: 50.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.14; 38.95% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CNOT3 Gene

HapMap Linkage Disequilibrium report
CNOT3
Human Gene Mutation Database (HGMD)
CNOT3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for CNOT3 Gene

Disorders for CNOT3 Gene

MalaCards: The human disease database

(2) MalaCards diseases for CNOT3 Gene - From: Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
precursor t-cell acute lymphoblastic leukemia
  • precursor t-cell acute lymphoblastic leukemia/lymphoma
retinitis pigmentosa
  • retinitis pigmentosa 1
- elite association - COSMIC cancer census association via MalaCards
Search CNOT3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CNOT3

Human Genome Epidemiology (HuGE) Navigator
CNOT3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CNOT3
genes like me logo Genes that share disorders with CNOT3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CNOT3 Gene

Publications for CNOT3 Gene

  1. Isolation and characterization of human orthologs of yeast CCR4-NOT complex subunits. (PMID: 10637334) Albert T.K. … Timmers H.T.M. (Nucleic Acids Res. 2000) 2 3 4 67
  2. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9734811) Ishikawa K. … Ohara O. (DNA Res. 1998) 2 3
  3. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3

Products for CNOT3 Gene

Sources for CNOT3 Gene

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