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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CNOT2 Gene

protein-coding   GIFtS: 62
GCID: GC12P070636

CCR4-NOT Transcription Complex, Subunit 2


(Previous symbol: NOT2)
  Search for CNOT2
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
CCR4-NOT Transcription Complex, Subunit 21 2     NOT2H2
NOT21 2 3 5     CCR4-NOT Transcription Complex Subunit 22
CDC362 3     Negative Regulator Of Transcription 22
CCR4-Associated Factor 22 3     

External Ids:    HGNC: 78781   Entrez Gene: 48482   Ensembl: ENSG000001115967   OMIM: 6049095   UniProtKB: Q9NZN83   
ORGUL members:         
NONCODE14:n410470      

Export aliases for CNOT2 gene to outside databases

Previous GC identifers: GC12P070508 GC12P070353 GC12P068923 GC12P067686


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CNOT2 Gene:
This gene encodes a subunit of the multi-component CCR4-NOT complex. The CCR4-NOT complex regulates mRNA synthesis
and degradation and is also thought to be involved in mRNA splicing, transport and localization. The encoded
protein interacts with histone deacetylases and functions as a repressor of polymerase II transcription.
Alternatively spliced transcript variants have been observed for this gene. (provided by RefSeq, Dec 2010)

GeneCards Summary for CNOT2 Gene: 
CNOT2 (CCR4-NOT transcription complex, subunit 2) is a protein-coding gene, and is affiliated with the lncRNA class. Among its related super-pathways are Deadenylation-dependent mRNA decay and Metabolism of RNA. GO annotations related to this gene include RNA polymerase II transcription cofactor activity.

UniProtKB/Swiss-Prot: CNOT2_HUMAN, Q9NZN8
Function: Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to
various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression
during translational initiation and general transcription regulation. Additional complex functions may be a
consequence of its influence on mRNA expression. Required for the CCR4-NOT complex structural integrity. Can
repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function
may specificly involve the N-Cor repressor complex containing HDAC3, NCOR1 and NCOR2. Involved in the maintenance
of emryonic stem (ES) cell identity

Gene Wiki entry for CNOT2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.2  NT_029419.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CNOT2 gene promoter:
         STAT5B   E2F-4   E2F-3a   STAT1   E2F-5   STAT6   E2F-2   STAT1alpha   E2F   E2F-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCNOT2 promoter sequence
   Search SABiosciences Chromatin IP Primers for CNOT2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CNOT2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q15   Ensembl cytogenetic band:  12q15   HGNC cytogenetic band: 12q15

CNOT2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CNOT2 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P070636:  view genomic region     (about GC identifiers)

Start:
70,636,774 bp from pter      End:
70,748,773 bp from pter
Size:
112,000 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CNOT2_HUMAN, Q9NZN8 (See protein sequence)
Recommended Name: CCR4-NOT transcription complex subunit 2  
Size: 540 amino acids; 59738 Da
Subunit: Component of the CCR4-NOT complex; distinct complexes seem to exist that differ in the participation of
probably mutually exclusive catalytic subunits. In the complex interacts directly with CNOT3. Interacts with
NCOR1, NCOR2. HDAC3 and GPS2
Subcellular location: Cytoplasm. Nucleus (Probable)
Developmental stage: Expressed in embryonic stem (ES) cells
Sequence caution: Sequence=AAF29095.1; Type=Frameshift; Positions=474; Sequence=AAQ13426.1; Type=Frameshift;
Positions=71, 76, 84, 98, 123, 370, 384, 393;
Secondary accessions: Q9H3E0 Q9NSX5 Q9NWR6 Q9P028
Alternative splicing: 5 isoforms:  Q9NZN8-1   Q9NZN8-2   Q9NZN8-3   Q9NZN8-4   Q9NZN8-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CNOT2: NX_Q9NZN8

Explore proteomics data for CNOT2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9NZN8

  • CNOT2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CNOT2 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001186231.1  NP_001186232.1  NP_055330.1  

    ENSEMBL proteins: 
     ENSP00000450318   ENSP00000450283   ENSP00000412091   ENSP00000448453   ENSP00000448490  
     ENSP00000449385   ENSP00000449801   ENSP00000447497   ENSP00000448255   ENSP00000450077  
     ENSP00000448024   ENSP00000449084   ENSP00000449659   ENSP00000449577   ENSP00000449260  
     ENSP00000448660   ENSP00000450090   ENSP00000449446   ENSP00000449917   ENSP00000448499  
     ENSP00000448883   ENSP00000446507   ENSP00000448298   ENSP00000448808   ENSP00000447813  
     ENSP00000447808   ENSP00000229195  
    Reactome Protein details: Q9NZN8
    Human Recombinant Protein Products for CNOT2: 
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    Novus Biologicals CNOT2 Lysate
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    Cloud-Clone Corp. Proteins for CNOT2 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus NAS10637334
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol TAS--
    GO:0030014CCR4-NOT complex IDA19558367

    CNOT2 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR007282 NOT

    Graphical View of Domain Structure for InterPro Entry Q9NZN8

    ProtoNet protein and cluster: Q9NZN8

    1 Blocks protein domain: IPB007282 NOT2/NOT3/NOT5

    UniProtKB/Swiss-Prot: CNOT2_HUMAN, Q9NZN8
    Similarity: Belongs to the CNOT2/3/5 family


    CNOT2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CNOT2_HUMAN, Q9NZN8
    Function: Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to
    various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression
    during translational initiation and general transcription regulation. Additional complex functions may be a
    consequence of its influence on mRNA expression. Required for the CCR4-NOT complex structural integrity. Can
    repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function
    may specificly involve the N-Cor repressor complex containing HDAC3, NCOR1 and NCOR2. Involved in the maintenance
    of emryonic stem (ES) cell identity

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001104RNA polymerase II transcription cofactor activity TAS10637334
    GO:0001226RNA polymerase II transcription corepressor binding IDA16712523
    GO:0004535contributes to poly(A)-specific ribonuclease activity IMP--
    GO:0005515protein binding IPI10637334
         
    CNOT2 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for CNOT2:
     Decreased POU5F1-GFP protein e  Increased circadian period len 

    Animal Models:
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    SwitchGear 3'UTR luciferase reporter plasmidCNOT2 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CNOT2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Deadenylation-dependent mRNA decay
    Deadenylation-dependent mRNA decay0.49
    Deadenylation of mRNA0.47
    RNA degradation0.49
    2Metabolism of mRNA
    Metabolism of mRNA0.92
    Metabolism of RNA0.92
    3Generic Transcription Pathway
    Gene Expression0.47
    4Translational Control
    Translational Control

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for CNOT2
        Translational Control

    5        Reactome Pathways for CNOT2
        Deadenylation of mRNA
    Deadenylation-dependent mRNA decay
    Metabolism of RNA
    Metabolism of mRNA
    Gene Expression


    1         Kegg Pathway  (Kegg details for CNOT2):
        RNA degradation


    CNOT2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CNOT2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 24)

    5/29 Interacting proteins for CNOT2 (Q9NZN81, 2, 3 ENSP000002291954) via UniProtKB, MINT, STRING, and/or I2D (see all 29)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CNOT3O751752, 3, ENSP000002212324MINT-2835143 MINT-66316 I2D: score=5 STRING: ENSP00000221232
    CNOT8Q9UFF92, 3, ENSP000002858964MINT-2835112 MINT-2835127 I2D: score=2 STRING: ENSP00000285896
    CNOT1A5YKK63, ENSP000003209494STRING: ENSP00000320949 I2D: score=4 
    CNOT6Q9ULM63, ENSP000002619514I2D: score=1 STRING: ENSP00000261951
    CNOT6LQ96LI53, ENSP000002649034I2D: score=1 STRING: ENSP00000264903
    About this table

    Gene Ontology (GO): 5/15 biological process terms (GO ID links to tree view) (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IDA14707134
    GO:0000288nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay TAS--
    GO:0000289nuclear-transcribed mRNA poly(A) tail shortening TAS--
    GO:0001829trophectodermal cell differentiation IEA--
    GO:0006355regulation of transcription, DNA-dependent ----

    CNOT2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CNOT2

    Search CenterWatch for drugs/clinical trials and news about CNOT2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CNOT2 gene (3 alternative transcripts): 
    NM_001199302.1  NM_001199303.1  NM_014515.5  

    Unigene Cluster for CNOT2:

    CCR4-NOT transcription complex, subunit 2
    Hs.133350  [show with all ESTs]
    Unigene Representative Sequence: AL833404
    18/43 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 43):
    ENST00000552231 ENST00000547780 ENST00000418359(uc009zro.3 uc009zrp.3 uc009zrq.3)
    ENST00000552319 ENST00000550160 ENST00000551661 ENST00000553078 ENST00000551132
    ENST00000548021 ENST00000552915 ENST00000549443 ENST00000548741 ENST00000552483
    ENST00000552422 ENST00000551179 ENST00000547321 ENST00000550641 ENST00000553020

    miRNA
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    8/133 QIAGEN miScript miRNA Assays for microRNAs that regulate CNOT2 (see all 133):
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    Additional mRNA sequence: 

    AF044215.1 AF113226.1 AF161480.1 AF180473.1 AK000662.1 AK095789.1 AK129966.1 AK307479.1 
    AK315715.1 AL833404.1 AY395696.1 BC002597.2 BC011826.2 NR_037615.1 

    24/34 DOTS entries (see all 34):

    DT.86837164  DT.98083206  DT.100838186  DT.100019013  DT.95316397  DT.102843048  DT.99954554  DT.100838194 
    DT.87017489  DT.91758946  DT.121176334  DT.91758932  DT.92034426  DT.100838197  DT.121176275  DT.121176364 
    DT.121176391  DT.121176393  DT.121176421  DT.40117354  DT.95200435  DT.99945897  DT.100044662  DT.100838189 

    24/438 AceView cDNA sequences (see all 438):

    BP368830 CF264708 AI024271 AI201638 AI832975 CA503057 CB112101 AL833404 
    AA659807 CD105615 AK095789 BM786306 BG054733 BI086964 BP334690 BQ286066 
    CR599299 BF594508 AA918467 BQ277944 AA010687 R77125 AA232692 BU509783 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for CNOT2 (see all 7)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17
    SP1:                                                              -     -           -           -                                               -               
    SP2:                                                                                                                                            -               
    SP3:                                                                                                                                                            
    SP4:        -     -                                   -     -     -     -     -     -                                                                           
    SP5:                                                                                                                                                            


    ECgene alternative splicing isoforms for CNOT2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CNOT2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGCCAACAA
    CNOT2 Expression
    About this image


    See CNOT2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CNOT2

    SOURCE GeneReport for Unigene cluster: Hs.133350

    UniProtKB/Swiss-Prot: CNOT2_HUMAN, Q9NZN8
    Tissue specificity: Ubiquitous. Highly expressed in brain, heart, thymus, spleen, kidney, liver, small intestine,
    placenta, lung and peripheral blood leukocytes

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CNOT2 gene from 10/26 species (see all 26)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cnot21 , 5 CCR4-NOT transcription complex, subunit 21, 5 95.43(n)1
    99.81(a)1
      10 (64.76 cM)5
    720681  NM_001037846.31  NP_001032935.21 
     1164851655 
    chicken
    (Gallus gallus)
    Aves CNOT21 CCR4-NOT transcription complex, subunit 2 93.72(n)
    99.23(a)
      417851  NM_001012808.1  NP_001012826.1 
    lizard
    (Anolis carolinensis)
    Reptilia CNOT26
    CCR4-NOT transcription complex, subunit 2
    85(a)
    1 ↔ 1
    GL343256.1(1870383-1935138)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.133122 Xenopus laevis transcribed sequence with moderate similarity more 88.73(n)    BU910022.1 
    zebrafish
    (Danio rerio)
    Actinopterygii 570957312   -- 82.23(n)    57095731 
    fruit fly
    (Drosophila melanogaster)
    Insecta Rga1 , 3 Regena1 54(a)3
    47.81(n)1
    43.65(a)1
      3 83B53
    406831  NM_079515.21  NP_524239.21 
    worm
    (Caenorhabditis elegans)
    Secernentea B0286.4c3   -- 47(a)
    (best of 3)
      II(4372945-4374492)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CDC36(YDL165W)4
    CDC361
    Component of the CCR4-NOT complex, which has multiple more4
    Cdc36p1
    46.18(n)1
    33.13(a)1
      4(164290-164865)4
    8513891, 4  NP_010116.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G077051 CCR4-NOT transcription complex subunit 2 48.15(n)
    43.1(a)
      837284  NM_001084009.1  NP_001077478.1 
    rice
    (Oryza sativa)
    Liliopsida Os.118622 Oryza sativa (japonica cultivar-group) cDNA clone0 more 73.88(n)    AK099785.1 


    ENSEMBL Gene Tree for CNOT2 (if available)
    TreeFam Gene Tree for CNOT2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CNOT2 gene
    18/73 SIMAP similar genes for CNOT2 using alignment to 23 protein entries:     CNOT2_HUMAN (see all proteins) (see all similar genes):
    NVL    PSD3    SENP7    ANKDD1A    LGALS3    QTRT1
    CARS2    NDUFS7    SCIMP    SPANXA2-OT1    TPTE2P1    USHBP1
    C12orf23    COX7A2    IFT74    TMEM67    ZNF568    ZNF738

    CNOT2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2142 SNPs in CNOT2 are shown (see all 2142)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1821079811,2
    --70634804(+) AATAAA/GTGAAT 1 -- us2k10--------
    rs1165116311,2
    C,F--70635340(+) ACCTAG/CAGTAC 2 -- us2k11Minor allele frequency- C:0.09WA 118
    rs37591561,2
    C,F,H--70635355(-) TACCTA/GCCTTA 2 -- us2k16Minor allele frequency- G:0.09NS EA NA 650
    rs37591551,2
    C,F,A--70635358(-) TAATAC/TCTACC 2 -- us2k11Minor allele frequency- T:0.07EA 120
    rs1868318611,2
    --70635367(+) TAAAAA/CTTTTT 2 -- us2k10--------
    rs1916713301,2
    --70635374(+) TTTTTA/TACAAA 2 -- us2k10--------
    rs1842669221,2
    --70635405(+) AATAAC/TAGGAC 2 -- us2k10--------
    rs15242471,2
    C,F,H--70635434(-) AAGCCG/AGGTTG 2 -- us2k110Minor allele frequency- A:0.06EA NS NA CSA WA 676
    rs37591531,2
    C,F,A,H--70635437(-) TTTAAG/ACCGGG 2 -- us2k110Minor allele frequency- A:0.38EA NS NA WA CSA 547
    rs1899152521,2
    --70635486(+) CAAAGA/TAAGTA 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for CNOT2 (70636774 - 70748773 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for CNOT2:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv1061540CNV Insertion17803354
    esv267925CNV Insertion20981092
    esv25808CNV Loss19812545
    nsv826415CNV Loss20364138
    dgv1446n71CNV Loss21882294
    dgv292n67CNV Loss20364138
    nsv899235CNV Gain21882294
    dgv1445n71CNV Gain+Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    CNOT2 for disorders           About MalaCards
    OMIM gene information: 604909    OMIM disorders: --


    CNOT2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): CNOT2
    Human Genome Epidemiology (HuGE) Navigator: CNOT2 (1 document)

    Export disorders for CNOT2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CNOT2 gene, integrated from 9 sources (see all 32):
    (articles sorted by number of sources associating them with CNOT2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation and characterization of human orthologs of yeast CCR4-NOT complex subunits. (PubMed id 10637334)1, 2, 3 Albert T.K....Timmers H.T. (2000)
    2. Involvement of the SMRT/NCoR-HDAC3 complex in transcriptional repression by the CNOT2 subunit of the human Ccr4-Not complex. (PubMed id 16712523)1, 2, 9 Jayne S....Timmers H.T. (2006)
    3. Cnot1, Cnot2, and Cnot3 maintain mouse and human ESC i dentity and inhibit extraembryonic differentiation. (PubMed id 22367759)1, 2 Zheng X....Hu G. (2012)
    4. CNOT2 depletion disrupts and inhibits the CCR4-NOT de adenylase complex and induces apoptotic cell death. (PubMed id 21299754)1, 2 Ito K....Yamamoto T. (2011)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    6. Human Ccr4-Not complexes contain variable deadenylase subunits. (PubMed id 19558367)1, 2 Lau N.C....Timmers H.T. (2009)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    9. Repression of promoter activity by CNOT2, a subunit of the transcription regulatory Ccr4-not complex. (PubMed id 14707134)1, 2 Zwartjes C.G....Timmers H.T. (2004)
    10. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2 Zhang Q.-H.... Chen Z. (2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Aliases
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      Query String
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    OMIM
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4848 HGNC: 7878 AceView: CNOT2 Ensembl:ENSG00000111596 euGenes: HUgn4848
    ECgene: CNOT2 Kegg: 4848 H-InvDB: CNOT2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CNOT2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CNOT2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CNOT2 gene:
    Search GeneIP for patents involving CNOT2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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