Aliases for CNOT2 Gene
External Ids for CNOT2 Gene
Previous HGNC Symbols for CNOT2 Gene
Previous GeneCards Identifiers for CNOT2 Gene
This gene encodes a subunit of the multi-component CCR4-NOT complex. The CCR4-NOT complex regulates mRNA synthesis and degradation and is also thought to be involved in mRNA splicing, transport and localization. The encoded protein interacts with histone deacetylases and functions as a repressor of polymerase II transcription. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2010]
GeneCards Summary for CNOT2 Gene
CNOT2 (CCR4-NOT Transcription Complex Subunit 2) is a Protein Coding gene. Diseases associated with CNOT2 include Space Motion Sickness. Among its related pathways are TP53 Regulates Transcription of Cell Cycle Genes and Regulation of TP53 Activity. GO annotations related to this gene include RNA polymerase II transcription cofactor activity and RNA polymerase II transcription corepressor binding.
UniProtKB/Swiss-Prot for CNOT2 Gene
Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Required for the CCR4-NOT complex structural integrity. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may specificly involve the N-Cor repressor complex containing HDAC3, NCOR1 and NCOR2. Involved in the maintenance of emryonic stem (ES) cell identity.