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Aliases for CNOT2 Gene

Aliases for CNOT2 Gene

  • CCR4-NOT Transcription Complex, Subunit 2 2 3
  • NOT2 3 4 6
  • CCR4-Associated Factor 2 3 4
  • CDC36 3 4
  • CCR4-NOT Transcription Complex Subunit 2 3
  • Negative Regulator Of Transcription 2 3
  • HSPC131 3
  • NOT2H 3

External Ids for CNOT2 Gene

Previous HGNC Symbols for CNOT2 Gene

  • NOT2

Previous GeneCards Identifiers for CNOT2 Gene

  • GC12P070508
  • GC12P070353
  • GC12P068923
  • GC12P070636
  • GC12P067686

Summaries for CNOT2 Gene

Entrez Gene Summary for CNOT2 Gene

  • This gene encodes a subunit of the multi-component CCR4-NOT complex. The CCR4-NOT complex regulates mRNA synthesis and degradation and is also thought to be involved in mRNA splicing, transport and localization. The encoded protein interacts with histone deacetylases and functions as a repressor of polymerase II transcription. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2010]

GeneCards Summary for CNOT2 Gene

CNOT2 (CCR4-NOT Transcription Complex, Subunit 2) is a Protein Coding gene. Among its related pathways are Translational Control and Gene Expression. GO annotations related to this gene include RNA polymerase II transcription cofactor activity and RNA polymerase II transcription corepressor binding.

UniProtKB/Swiss-Prot for CNOT2 Gene

  • Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Required for the CCR4-NOT complex structural integrity. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may specificly involve the N-Cor repressor complex containing HDAC3, NCOR1 and NCOR2. Involved in the maintenance of emryonic stem (ES) cell identity.

Gene Wiki entry for CNOT2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CNOT2 Gene

Genomics for CNOT2 Gene

Regulatory Elements for CNOT2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CNOT2 Gene

Start:
70,242,882 bp from pter
End:
70,354,993 bp from pter
Size:
112,112 bases
Orientation:
Plus strand

Genomic View for CNOT2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CNOT2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CNOT2 Gene

Proteins for CNOT2 Gene

  • Protein details for CNOT2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NZN8-CNOT2_HUMAN
    Recommended name:
    CCR4-NOT transcription complex subunit 2
    Protein Accession:
    Q9NZN8
    Secondary Accessions:
    • Q9H3E0
    • Q9NSX5
    • Q9NWR6
    • Q9P028

    Protein attributes for CNOT2 Gene

    Size:
    540 amino acids
    Molecular mass:
    59738 Da
    Quaternary structure:
    • Component of the CCR4-NOT complex; distinct complexes seem to exist that differ in the participation of probably mutually exclusive catalytic subunits. In the complex interacts directly with CNOT3. Interacts with NCOR1, NCOR2. HDAC3 and GPS2.
    SequenceCaution:
    • Sequence=AAF29095.1; Type=Frameshift; Positions=474; Evidence={ECO:0000305}; Sequence=AAQ13426.1; Type=Frameshift; Positions=71, 76, 84, 98, 123, 370, 384, 393; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CNOT2 Gene

    Alternative splice isoforms for CNOT2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CNOT2 Gene

Proteomics data for CNOT2 Gene at MOPED

Post-translational modifications for CNOT2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CNOT2 (NOT2)

No data available for DME Specific Peptides for CNOT2 Gene

Domains for CNOT2 Gene

Protein Domains for CNOT2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for CNOT2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NZN8

UniProtKB/Swiss-Prot:

CNOT2_HUMAN :
  • Q9NZN8
Family:
  • Belongs to the CNOT2/3/5 family.
genes like me logo Genes that share domains with CNOT2: view

No data available for Gene Families for CNOT2 Gene

Function for CNOT2 Gene

Molecular function for CNOT2 Gene

UniProtKB/Swiss-Prot Function: Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Required for the CCR4-NOT complex structural integrity. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may specificly involve the N-Cor repressor complex containing HDAC3, NCOR1 and NCOR2. Involved in the maintenance of emryonic stem (ES) cell identity.

Gene Ontology (GO) - Molecular Function for CNOT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001104 RNA polymerase II transcription cofactor activity TAS 10637334
GO:0001226 RNA polymerase II transcription corepressor binding IDA 16712523
GO:0004535 contributes_to poly(A)-specific ribonuclease activity IMP 21299754
GO:0005515 protein binding IPI 10637334
genes like me logo Genes that share ontologies with CNOT2: view

Phenotypes for CNOT2 Gene

genes like me logo Genes that share phenotypes with CNOT2: view

Animal Model Products

CRISPR Products

miRNA for CNOT2 Gene

miRTarBase miRNAs that target CNOT2

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CNOT2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for CNOT2 Gene

Localization for CNOT2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CNOT2 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CNOT2 Gene COMPARTMENTS Subcellular localization image for CNOT2 gene
Compartment Confidence
nucleus 5
cytosol 4
extracellular 2
plasma membrane 2
cytoskeleton 1
endoplasmic reticulum 1
golgi apparatus 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CNOT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus NAS 10637334
GO:0005737 cytoplasm IDA 21299754
GO:0005829 cytosol TAS --
GO:0016020 membrane IDA 19946888
GO:0030014 CCR4-NOT complex IDA 19558367
genes like me logo Genes that share ontologies with CNOT2: view

Pathways for CNOT2 Gene

genes like me logo Genes that share pathways with CNOT2: view

Pathways by source for CNOT2 Gene

1 Cell Signaling Technology pathway for CNOT2 Gene
1 KEGG pathway for CNOT2 Gene

Gene Ontology (GO) - Biological Process for CNOT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 14707134
GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay TAS --
GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening TAS --
GO:0001829 trophectodermal cell differentiation IEA --
GO:0006355 regulation of transcription, DNA-templated --
genes like me logo Genes that share ontologies with CNOT2: view

Transcripts for CNOT2 Gene

Unigene Clusters for CNOT2 Gene

CCR4-NOT transcription complex, subunit 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CNOT2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CNOT2 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17
SP1: - - - - -
SP2: -
SP3:
SP4: - - - - - - - -
SP5:
SP6: - -
SP7: -

Relevant External Links for CNOT2 Gene

GeneLoc Exon Structure for
CNOT2
ECgene alternative splicing isoforms for
CNOT2

Expression for CNOT2 Gene

mRNA expression in normal human tissues for CNOT2 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CNOT2 Gene

SOURCE GeneReport for Unigene cluster for CNOT2 Gene Hs.133350

mRNA Expression by UniProt/SwissProt for CNOT2 Gene

Q9NZN8-CNOT2_HUMAN
Tissue specificity: Ubiquitous. Highly expressed in brain, heart, thymus, spleen, kidney, liver, small intestine, placenta, lung and peripheral blood leukocytes.
genes like me logo Genes that share expressions with CNOT2: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for CNOT2 Gene

Orthologs for CNOT2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CNOT2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CNOT2 35
  • 96.9 (n)
  • 96.02 (a)
CNOT2 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CNOT2 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CNOT2 35
  • 98.64 (n)
  • 100 (a)
CNOT2 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cnot2 35
  • 95.43 (n)
  • 99.81 (a)
Cnot2 16
Cnot2 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CNOT2 36
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CNOT2 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cnot2 35
  • 95.25 (n)
  • 99.77 (a)
chicken
(Gallus gallus)
Aves CNOT2 35
  • 93.72 (n)
  • 99.23 (a)
CNOT2 36
  • 99 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CNOT2 36
  • 85 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.13312 35
tropical clawed frog
(Silurana tropicalis)
Amphibia cnot2 35
  • 88.46 (n)
  • 96.54 (a)
Str.5823 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13407 35
zebrafish
(Danio rerio)
Actinopterygii cnot2 35
  • 79.05 (n)
  • 88.59 (a)
cnot2 36
  • 88 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG15262 36
  • 21 (a)
OneToMany
CG6576 36
  • 27 (a)
OneToMany
Rga 36
  • 31 (a)
OneToMany
Rga 37
  • 54 (a)
worm
(Caenorhabditis elegans)
Secernentea ntl-2 35
  • 49.41 (n)
  • 43.77 (a)
ntl-2 36
  • 32 (a)
OneToMany
tag-153 36
  • 16 (a)
OneToMany
B0286.4c 37
  • 47 (a)
B0286.4a 37
  • 43 (a)
B0286.4b 37
  • 45 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACL151C 35
  • 44.98 (n)
  • 36.14 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CDC36 35
  • 46.79 (n)
  • 33.73 (a)
CDC36 36
  • 34 (a)
OneToOne
CDC36 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D12408g 35
  • 47.39 (n)
  • 33.13 (a)
corn
(Zea mays)
Liliopsida Zm.3513 35
rice
(Oryza sativa)
Liliopsida Os.11862 35
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes not2 35
  • 46.13 (n)
  • 37.05 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2536 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8375 36
  • 29 (a)
OneToMany
CSA.8562 36
  • 76 (a)
OneToMany
Species with no ortholog for CNOT2:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CNOT2 Gene

ENSEMBL:
Gene Tree for CNOT2 (if available)
TreeFam:
Gene Tree for CNOT2 (if available)

Paralogs for CNOT2 Gene

genes like me logo Genes that share paralogs with CNOT2: view

No data available for Paralogs for CNOT2 Gene

Variants for CNOT2 Gene

Sequence variations from dbSNP and Humsavar for CNOT2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs717956 -- 70,308,307(-) TCACA(A/C)GAGAA intron-variant
rs720653 -- 70,324,657(-) TGGCT(A/G)GATCT intron-variant
rs788375 -- 70,295,033(-) TCTGT(A/G)ATGTT intron-variant
rs788376 -- 70,293,236(-) GTGCA(G/T)TGAGT intron-variant
rs788377 -- 70,291,201(-) TTATT(A/G)GTAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CNOT2 Gene

Variant ID Type Subtype PubMed ID
esv1061540 CNV Insertion 17803354
dgv292n67 CNV Loss 20364138
esv267925 CNV Insertion 20981092
esv25808 CNV Loss 19812545
nsv826415 CNV Loss 20364138
nsv899235 CNV Gain 21882294
dgv1445n71 CNV Gain+Loss 21882294
dgv1446n71 CNV Loss 21882294

Relevant External Links for CNOT2 Gene

HapMap Linkage Disequilibrium report
CNOT2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CNOT2 Gene

Disorders for CNOT2 Gene

Relevant External Links for CNOT2

Genetic Association Database (GAD)
CNOT2
Human Genome Epidemiology (HuGE) Navigator
CNOT2
genes like me logo Genes that share disorders with CNOT2: view

No data available for UniProtKB/Swiss-Prot for CNOT2 Gene

Publications for CNOT2 Gene

  1. Involvement of the SMRT/NCoR-HDAC3 complex in transcriptional repression by the CNOT2 subunit of the human Ccr4-Not complex. (PMID: 16712523) Jayne S. … Timmers H.T. (Biochem. J. 2006) 3 4 23
  2. Isolation and characterization of human orthologs of yeast CCR4-NOT complex subunits. (PMID: 10637334) Albert T.K. … Timmers H.T.M. (Nucleic Acids Res. 2000) 2 3 4
  3. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 3 4
  4. Human Ccr4-Not complexes contain variable deadenylase subunits. (PMID: 19558367) Lau N.C. … Timmers H.T. (Biochem. J. 2009) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for CNOT2 Gene

Sources for CNOT2 Gene

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