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CNOT2 Gene

protein-coding   GIFtS: 62
GCID: GC12P070636

CCR4-NOT Transcription Complex, Subunit 2


(Previous symbol: NOT2)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
CCR4-NOT Transcription Complex, Subunit 21 2     NOT2H2
NOT21 2 3 5     CCR4-NOT Transcription Complex Subunit 22
CDC362 3     Negative Regulator Of Transcription 22
CCR4-Associated Factor 22 3     

External Ids:    HGNC: 78781   Entrez Gene: 48482   Ensembl: ENSG000001115967   OMIM: 6049095   UniProtKB: Q9NZN83   

Export aliases for CNOT2 gene to outside databases

Previous GC identifers: GC12P070508 GC12P070353 GC12P068923 GC12P067686


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CNOT2 Gene:
This gene encodes a subunit of the multi-component CCR4-NOT complex. The CCR4-NOT complex regulates mRNA synthesis
and degradation and is also thought to be involved in mRNA splicing, transport and localization. The encoded
protein interacts with histone deacetylases and functions as a repressor of polymerase II transcription.
Alternatively spliced transcript variants have been observed for this gene. (provided by RefSeq, Dec 2010)

GeneCards Summary for CNOT2 Gene:
CNOT2 (CCR4-NOT transcription complex, subunit 2) is a protein-coding gene. GO annotations related to this gene include RNA polymerase II transcription cofactor activity and RNA polymerase II transcription corepressor binding.

UniProtKB/Swiss-Prot: CNOT2_HUMAN, Q9NZN8
Function: Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to
various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression
during translational initiation and general transcription regulation. Additional complex functions may be a
consequence of its influence on mRNA expression. Required for the CCR4-NOT complex structural integrity. Can
repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function
may specificly involve the N-Cor repressor complex containing HDAC3, NCOR1 and NCOR2. Involved in the maintenance
of emryonic stem (ES) cell identity

Gene Wiki entry for CNOT2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NT_029419.13  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CNOT2 gene promoter:
         STAT5B   E2F-4   E2F-3a   STAT1   E2F-5   STAT6   E2F-2   STAT1alpha   E2F   E2F-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCNOT2 promoter sequence
   Search Chromatin IP Primers for CNOT2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CNOT2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q15   Ensembl cytogenetic band:  12q15   HGNC cytogenetic band: 12q15

CNOT2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CNOT2 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P070636:  view genomic region     (about GC identifiers)

Start:
70,636,774 bp from pter      End:
70,748,773 bp from pter
Size:
112,000 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CNOT2_HUMAN, Q9NZN8 (See protein sequence)
Recommended Name: CCR4-NOT transcription complex subunit 2  
Size: 540 amino acids; 59738 Da
Subunit: Component of the CCR4-NOT complex; distinct complexes seem to exist that differ in the participation of
probably mutually exclusive catalytic subunits. In the complex interacts directly with CNOT3. Interacts with
NCOR1, NCOR2. HDAC3 and GPS2
Developmental stage: Expressed in embryonic stem (ES) cells
Sequence caution: Sequence=AAF29095.1; Type=Frameshift; Positions=474; Sequence=AAQ13426.1; Type=Frameshift;
Positions=71, 76, 84, 98, 123, 370, 384, 393;
2 PDB 3D structures from and Proteopedia for CNOT2:
4C0D (3D)        4C0F (3D)    
Secondary accessions: Q9H3E0 Q9NSX5 Q9NWR6 Q9P028
Alternative splicing: 5 isoforms:  Q9NZN8-1   Q9NZN8-2   Q9NZN8-3   Q9NZN8-4   Q9NZN8-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CNOT2: NX_Q9NZN8

Explore proteomics data for CNOT2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CNOT2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001186231.1  NP_001186232.1  NP_055330.1  

    ENSEMBL proteins: 
     ENSP00000450318   ENSP00000450283   ENSP00000412091   ENSP00000448453   ENSP00000448490  
     ENSP00000449385   ENSP00000449801   ENSP00000447497   ENSP00000448255   ENSP00000450077  
     ENSP00000448024   ENSP00000449084   ENSP00000449659   ENSP00000449577   ENSP00000449260  
     ENSP00000448660   ENSP00000450090   ENSP00000449446   ENSP00000449917   ENSP00000448499  
     ENSP00000448883   ENSP00000446507   ENSP00000448298   ENSP00000448808   ENSP00000447813  
     ENSP00000447808   ENSP00000229195  
    Reactome Protein details: Q9NZN8

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    antibodies-online proteins for CNOT2 (5 products) 

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR007282 NOT

    Graphical View of Domain Structure for InterPro Entry Q9NZN8

    ProtoNet protein and cluster: Q9NZN8

    1 Blocks protein domain: IPB007282 NOT2/NOT3/NOT5

    UniProtKB/Swiss-Prot: CNOT2_HUMAN, Q9NZN8
    Similarity: Belongs to the CNOT2/3/5 family


    Find genes that share domains with CNOT2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CNOT2_HUMAN, Q9NZN8
    Function: Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to
    various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression
    during translational initiation and general transcription regulation. Additional complex functions may be a
    consequence of its influence on mRNA expression. Required for the CCR4-NOT complex structural integrity. Can
    repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function
    may specificly involve the N-Cor repressor complex containing HDAC3, NCOR1 and NCOR2. Involved in the maintenance
    of emryonic stem (ES) cell identity

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001104RNA polymerase II transcription cofactor activity TAS10637334
    GO:0001226RNA polymerase II transcription corepressor binding IDA16712523
    GO:0004535contributes to poly(A)-specific ribonuclease activity IMP--
    GO:0005515protein binding IPI10637334
         
    Find genes that share ontologies with CNOT2           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for CNOT2:
     Decreased POU5F1-GFP protein e  Increased circadian period len 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for CNOT2

    miRNA
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    hsa-miR-576-3p hsa-miR-100* hsa-miR-520f hsa-miR-759 hsa-miR-130b hsa-miR-92b hsa-miR-761 hsa-miR-130a*
    SwitchGear 3'UTR luciferase reporter plasmidCNOT2 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CNOT2_HUMAN, Q9NZN8: Cytoplasm. Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    extracellular2
    plasma membrane2
    cytoskeleton1
    endoplasmic reticulum1
    golgi apparatus1
    mitochondrion1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus NAS10637334
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol TAS--
    GO:0030014CCR4-NOT complex IDA19558367

    Find genes that share ontologies with CNOT2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CNOT2 About    
    See pathways by source

    SuperPathContained pathways About
    1Deadenylation-dependent mRNA decay
    Deadenylation-dependent mRNA decay0.48
    Deadenylation of mRNA0.48
    RNA degradation0.48
    2Gene Expression
    Gene Expression0.40
    3Translational Control
    Translational Control


    Find genes that share SuperPaths with CNOT2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for CNOT2
        Translational Control


    1 Reactome Pathway for CNOT2
        Deadenylation of mRNA


    1 Kegg Pathway  (Kegg details for CNOT2):
        RNA degradation

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CNOT2
    Interactions:

        GeneGlobe Interaction Network for CNOT2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CNOT2 (Q9NZN81, 2, 3 ENSP000002291954) via UniProtKB, MINT, STRING, and/or I2D (see all 124)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CNOT3O751751, 2, 3, ENSP000002212324EBI-743033,EBI-743073 MINT-2835143 MINT-66316 I2D: score=5 STRING: ENSP00000221232
    CNOT8Q9UFF91, 2, 3, ENSP000002858964EBI-743033,EBI-742299 MINT-2835112 MINT-2835127 I2D: score=2 STRING: ENSP00000285896
    CNOT1A5YKK61, 3, ENSP000003209494STRING: ENSP00000320949 EBI-743033,EBI-1222758 I2D: score=4 
    EYA2O001673, ENSP000003336404I2D: score=3 STRING: ENSP00000333640
    CNOT6LQ96LI53, ENSP000002649034I2D: score=1 STRING: ENSP00000264903
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IDA14707134
    GO:0000288nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay TAS--
    GO:0000289nuclear-transcribed mRNA poly(A) tail shortening TAS--
    GO:0001829trophectodermal cell differentiation IEA--
    GO:0006355regulation of transcription, DNA-templated ----

    Find genes that share ontologies with CNOT2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CNOT2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CNOT2 gene (3 alternative transcripts): 
    NM_001199302.1  NM_001199303.1  NM_014515.5  

    Unigene Cluster for CNOT2:

    CCR4-NOT transcription complex, subunit 2
    Hs.133350  [show with all ESTs]
    Unigene Representative Sequence: AL833404
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 43):
    ENST00000552231 ENST00000547780 ENST00000418359(uc009zro.3 uc009zrp.3 uc009zrq.3)
    ENST00000552319 ENST00000550160 ENST00000551661 ENST00000553078 ENST00000551132
    ENST00000548021 ENST00000552915 ENST00000549443 ENST00000548741 ENST00000552483
    ENST00000552422 ENST00000551179 ENST00000547321 ENST00000550641 ENST00000553020

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    hsa-miR-576-3p hsa-miR-100* hsa-miR-520f hsa-miR-759 hsa-miR-130b hsa-miR-92b hsa-miR-761 hsa-miR-130a*
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    Additional mRNA sequence: 

    AF044215.1 AF113226.1 AF161480.1 AF180473.1 AK000662.1 AK095789.1 AK129966.1 AK307479.1 
    AK315715.1 AL833404.1 AY395696.1 BC002597.2 BC011826.2 NR_037615.1 

    Selected DOTS entries (see all 34):

    DT.86837164  DT.98083206  DT.100838186  DT.100019013  DT.95316397  DT.102843048  DT.99954554  DT.100838194 
    DT.87017489  DT.91758946  DT.121176334  DT.91758932  DT.92034426  DT.100838197  DT.121176275  DT.121176364 
    DT.121176391  DT.121176393  DT.121176421  DT.40117354  DT.95200435  DT.99945897  DT.100044662  DT.100838189 

    Selected AceView cDNA sequences (see all 438):

    AA659807 AL833404 BF594508 AA918467 BQ277944 AA010687 R77125 AA232692 
    BU509783 AW511332 BM835500 AA972211 AI090119 AF147398 BM722426 BQ646717 
    AW182430 N47923 AW673688 AA664363 BM129496 AI696775 AA234384 BI093732 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CNOT2 (see all 7)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17
    SP1:                                                              -     -           -           -                                               -               
    SP2:                                                                                                                                            -               
    SP3:                                                                                                                                                            
    SP4:        -     -                                   -     -     -     -     -     -                                                                           
    SP5:                                                                                                                                                            


    ECgene alternative splicing isoforms for CNOT2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CNOT2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGCCAACAA
    CNOT2 Expression
    About this image

    CNOT2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CNOT2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.133350

    UniProtKB/Swiss-Prot: CNOT2_HUMAN, Q9NZN8
    Tissue specificity: Ubiquitous. Highly expressed in brain, heart, thymus, spleen, kidney, liver, small intestine,
    placenta, lung and peripheral blood leukocytes

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CNOT2 gene from Selected species (see all 23)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cnot21 , 5 CCR4-NOT transcription complex, subunit 21, 5 95.43(n)1
    99.81(a)1
      10 (64.76 cM)5
    720681  NM_001037847.21  NP_001032936.21 
     1164851655 
    chicken
    (Gallus gallus)
    Aves CNOT21 CCR4-NOT transcription complex, subunit 2 93.72(n)
    99.23(a)
      417851  NM_001012808.1  NP_001012826.1 
    lizard
    (Anolis carolinensis)
    Reptilia CNOT26
    CCR4-NOT transcription complex, subunit 2
    85(a)
    1 ↔ 1
    GL343256.1(1870383-1935138)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.133122 Xenopus laevis transcribed sequence with moderate similarity more 88.73(n)    BU910022.1 
    zebrafish
    (Danio rerio)
    Actinopterygii 570957312   -- 82.23(n)    57095731 
    fruit fly
    (Drosophila melanogaster)
    Insecta Rga3   -- 54(a)   3 83B5   --
    worm
    (Caenorhabditis elegans)
    Secernentea B0286.4c3
    ntl-21
    ntl-21 47(a)
    (best of 3)3
    49.41(n)1
    43.77(a)1
      II(4372945-4374492)3
    1737731  NM_062371.41  NP_494772.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CDC36(YDL165W)4
    CDC361
    Component of the CCR4-NOT complex, which has multiple more4
    CDC361
    46.79(n)1
    33.73(a)1
      4(164290-164865)4
    8513891, 4  NP_010116.11, 4 
    rice
    (Oryza sativa)
    Liliopsida Os.118622 Oryza sativa (japonica cultivar-group) cDNA clone0 more 73.88(n)    AK099785.1 


    ENSEMBL Gene Tree for CNOT2 (if available)
    TreeFam Gene Tree for CNOT2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CNOT2 gene
    Selected SIMAP similar genes for CNOT2 using alignment to 23 protein entries:     CNOT2_HUMAN (see all proteins) (see all similar genes):
    NVL    PSD3    SENP7    ANKDD1A    LGALS3    QTRT1
    CARS2    NDUFS7    SCIMP    SPANXA2-OT1    TPTE2P1    USHBP1
    C12orf23    COX7A2    IFT74    TMEM67    ZNF568    ZNF738

    Find genes that share paralogs with CNOT2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CNOT2 (see all 2142)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1821079811,2
    --70634804(+) AATAAA/GTGAAT 1 -- us2k10--------
    rs1165116311,2
    C,F--70635340(+) ACCTAG/CAGTAC 2 -- us2k11Minor allele frequency- C:0.09WA 118
    rs37591561,2
    C,F,H--70635355(-) TACCTA/GCCTTA 2 -- us2k16Minor allele frequency- G:0.09NS EA NA 650
    rs37591551,2
    C,F,A--70635358(-) TAATAC/TCTACC 2 -- us2k11Minor allele frequency- T:0.07EA 120
    rs1868318611,2
    --70635367(+) TAAAAA/CTTTTT 2 -- us2k10--------
    rs1916713301,2
    --70635374(+) TTTTTA/TACAAA 2 -- us2k10--------
    rs1842669221,2
    --70635405(+) AATAAC/TAGGAC 2 -- us2k10--------
    rs15242471,2
    C,F,H--70635434(-) AAGCCG/AGGTTG 2 -- us2k110Minor allele frequency- A:0.06EA NS NA CSA WA 676
    rs37591531,2
    C,F,A,H--70635437(-) TTTAAG/ACCGGG 2 -- us2k110Minor allele frequency- A:0.38EA NS NA WA CSA 547
    rs1899152521,2
    --70635486(+) CAAAGA/TAAGTA 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for CNOT2 (70636774 - 70748773 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for CNOT2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1061540CNV Insertion17803354
    esv267925CNV Insertion20981092
    esv25808CNV Loss19812545
    nsv826415CNV Loss20364138
    dgv1446n71CNV Loss21882294
    dgv292n67CNV Loss20364138
    nsv899235CNV Gain21882294
    dgv1445n71CNV Gain+Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CNOT2
    DNA2.0 Custom Variant and Variant Library Synthesis for CNOT2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604909    OMIM disorders: --


    Find genes that share disorders with CNOT2           About GenesLikeMe

    Genetic Association Database (GAD): CNOT2
    Human Genome Epidemiology (HuGE) Navigator: CNOT2 (1 document)

    Export disorders for CNOT2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CNOT2 gene, integrated from 10 sources (see all 34):
    (articles sorted by number of sources associating them with CNOT2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation and characterization of human orthologs of yeast CCR4-NOT complex subunits. (PubMed id 10637334)1, 2, 3 Albert T.K....Timmers H.T.M. (Nucleic Acids Res. 2000)
    2. Involvement of the SMRT/NCoR-HDAC3 complex in transcriptional repression by the CNOT2 subunit of the human Ccr4-Not complex. (PubMed id 16712523)1, 2, 9 Jayne S.... Timmers H.T. (Biochem. J. 2006)
    3. Cnot1, Cnot2, and Cnot3 maintain mouse and human ESC identity and inhibit extraembryonic differentiation. (PubMed id 22367759)1, 2 Zheng X.... Hu G. (Stem Cells 2012)
    4. CNOT2 depletion disrupts and inhibits the CCR4-NOT deadenylase complex and induces apoptotic cell death. (PubMed id 21299754)1, 2 Ito K.... Yamamoto T. (Genes Cells 2011)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    6. Human Ccr4-Not complexes contain variable deadenylase subunits. (PubMed id 19558367)1, 2 Lau N.C.... Timmers H.T. (Biochem. J. 2009)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Repression of promoter activity by CNOT2, a subunit of the transcription regulatory Ccr4-not complex. (PubMed id 14707134)1, 2 Zwartjes C.G.... Timmers H.T. (J. Biol. Chem. 2004)
    10. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2 Zhang Q.-H.... Chen Z. (Genome Res. 2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4848 HGNC: 7878 AceView: CNOT2 Ensembl:ENSG00000111596 euGenes: HUgn4848
    ECgene: CNOT2 Kegg: 4848 H-InvDB: CNOT2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CNOT2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CNOT2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CNOT2 gene:
    Search GeneIP for patents involving CNOT2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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