CNOT2 Gene
protein-coding GIFtS: 61
GCID: GC12P070636
|
|
CCR4-NOT transcription complex, subunit 2
(Previous symbol: NOT2)
| |
Aliases
for CNOT2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA
Quality score for the ORGUL clustered with this gene is 3
| Aliases |
|---|
| CCR4-NOT Transcription Complex, Subunit 21 2 | | CCR4-Associated Factor 22 3 | | NOT21 2 3 5 | | CCR4-NOT Transcription Complex Subunit 22 | | CDC361 2 3 | | Negative Regulator Of Transcription 22 | | NOT2H1 2 | | |
| External Ids: | HGNC: 78781 | Entrez Gene: 48482 | Ensembl: ENSG000001115967 | OMIM: 6049095 | UniProtKB: Q9NZN83 |
|---|
| | ORGUL members: | |
|---|
| NONCODE:n410470 | |
Export aliases for CNOT2 gene to outside databasesPrevious GC identifers: GC12P070508 GC12P070353 GC12P068923 GC12P067686
Summaries
for CNOT2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CNOT2:
This gene encodes a subunit of the multi-component CCR4-NOT complex. The CCR4-NOT complex regulates mRNA synthesis anddegradation and is also thought to be involved in mRNA splicing, transport and localization. The encoded proteininteracts with histone deacetylases and functions as a repressor of polymerase II transcription. Alternatively splicedtranscript variants have been observed for this gene. (provided by RefSeq, Dec 2010)
UniProtKB/Swiss-Prot: CNOT2_HUMAN, Q9NZN8Function: The CCR4-NOT complex functions as general transcription regulation complex
Gene Wiki entry for CNOT2
|
Genomic Views
for CNOT2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000012.11 NC_018923.1 NT_029419.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CNOT2 gene promoter:
STAT5B E2F-4 E2F-3a STAT1 E2F-5 STAT6 E2F-2 STAT1alpha E2F E2F-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for CNOT2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CNOT2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12q15 Ensembl cytogenetic band: 12q15 HGNC cytogenetic band: 12q15CNOT2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12P070636: view genomic region
(about GC identifiers)
Start:
|
70,636,774 bp from pter |
End:
|
70,748,773 bp from pter |
Size:
|
112,000 bases |
Orientation:
|
plus strand |
|
Proteins
for CNOT2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CNOT2_HUMAN, Q9NZN8 (See
protein sequence)Recommended Name: CCR4-NOT transcription complex subunit 2 Size: 540 amino acids; 59738 Da
Subunit: Subunit of the CCR4-NOT core complex that contains CHAF1A, CHAF1B, CNOT1, CNOT2, CNOT3, CNOT4, CNOT6 and CNOT8
Subcellular location: Cytoplasm (Probable). Nucleus (Probable)
Sequence caution: Sequence=AAF29095.1; Type=Frameshift; Positions=474; Sequence=AAQ13426.1; Type=Frameshift;Positions=71, 76, 84, 98, 123, 370, 384, 393;
Secondary accessions: Q9H3E0 Q9NSX5 Q9NWR6 Q9P028Alternative splicing: 5 isoforms: Q9NZN8-1 Q9NZN8-2 Q9NZN8-3 Q9NZN8-4 Q9NZN8-5 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for CNOT2: NX_Q9NZN8
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9NZN8
CNOT2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001186231.1 NP_001186232.1 NP_055330.1
ENSEMBL proteins: ENSP00000450318 ENSP00000450283 ENSP00000412091 ENSP00000448453 ENSP00000448490 ENSP00000449385 ENSP00000449801 ENSP00000447497 ENSP00000448255 ENSP00000450077 ENSP00000448024 ENSP00000449084 ENSP00000449659 ENSP00000449577 ENSP00000449260 ENSP00000448660 ENSP00000450090 ENSP00000449446 ENSP00000449917 ENSP00000448499 ENSP00000448883 ENSP00000447491 ENSP00000446507 ENSP00000448298 ENSP00000448808 ENSP00000447813 ENSP00000447808 ENSP00000229195 Reactome Protein details: Q9NZN8
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
CNOT2 for ontologies About GeneDecksing
CNOT2 Antibody Products:
Assay Products for CNOT2: |
Protein
Domains /
Families
for CNOT2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CNOT2 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9NZN8ProtoNet protein and cluster: Q9NZN8 1 Blocks protein family: IPB007282 NOT2/NOT3/NOT5
UniProtKB/Swiss-Prot: CNOT2_HUMAN, Q9NZN8Similarity: Belongs to the CNOT2/3/5 family |
Function
for CNOT2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: CNOT2_HUMAN, Q9NZN8Function: The CCR4-NOT complex functions as general transcription regulation complex
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CNOT2 (see all 7)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CNOT2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 3): CNOT2 (NM_014515) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CNOT2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CNOT2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CNOT2 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0001104 | RNA polymerase II transcription cofactor activity |
TAS | 10637334 |
CNOT2 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for CNOT2:
|
Pathways & Interactions
for CNOT2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Deadenylation-dependent mRNA decay | | | 2 | Metabolism of mRNA | | | 3 | Translational Control | | | 4 | Generic Transcription Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 
Cell Signaling Technology (CST) Pathway for CNOT2
5 
Reactome Pathways for CNOT2
1 
Kegg Pathway (Kegg details for CNOT2):
CNOT2 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CNOT2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 24)
5/29 Interacting proteins for CNOT2 (Q9NZN82, 3 ENSP000002291954) via UniProtKB, MINT, STRING, and/or I2D (see all 29)About this table
Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000288 | nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay |
TAS | -- | | GO:0000289 | nuclear-transcribed mRNA poly(A) tail shortening |
TAS | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
-- | -- | | GO:0006357 | regulation of transcription from RNA polymerase II promoter |
NAS | 10637334 | | GO:0010467 | gene expression |
TAS | -- |
CNOT2 for ontologies About GeneDecksing
|
Drugs & Compounds
for CNOT2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CNOT2
Search CenterWatch for drugs/clinical trials and news about CNOT2
|
Transcripts
for CNOT2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CNOT2 gene (3 alternative transcripts): NM_001199302.1 NM_001199303.1 NM_014515.5 Unigene Cluster for CNOT2: CCR4-NOT transcription complex, subunit 2 Hs.133350 [show with all ESTs]Unigene Representative Sequence: AL83340418/43 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 43): ENST00000552231 ENST00000547780 ENST00000418359(uc009zro.3 uc009zrp.3 uc009zrq.3)
ENST00000552319 ENST00000550160 ENST00000551661 ENST00000553078 ENST00000551132
ENST00000548021 ENST00000552915 ENST00000549443 ENST00000548741 ENST00000552483
ENST00000552422 ENST00000551179 ENST00000547321 ENST00000550641 ENST00000553020
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CNOT2 (see all 7)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CNOT2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): CNOT2 (NM_014515) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CNOT2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CNOT2 |
Additional cDNA sequence: AF044215.1 AF113226.1 AF161480.1 AF180473.1 AK000662.1 AK095789.1 AK129966.1 AK307479.1 AK315715.1 AL833404.1 AY395696.1 BC002597.2 BC011826.2 NR_037615.1 24/34 DOTS entries (see all 34): DT.86837164 DT.98083206 DT.100838186 DT.100019013 DT.95316397 DT.102843048 DT.99954554 DT.100838194 DT.87017489 DT.91758946 DT.121176334 DT.91758932 DT.92034426 DT.100838197 DT.121176275 DT.121176364 DT.121176391 DT.121176393 DT.121176421 DT.40117354 DT.95200435 DT.99945897 DT.100044662 DT.100838189 24/438 AceView cDNA sequences (see all 438): AA918467 R77125 BM835500 AA232692 AW511332 BU509783 AI090119 AA972211 AF147398 BM722426 AW182430 BQ646717 N47923 AW673688 BM129496 AA664363 AA234384 AI696775 BI093732 BG054930 W93220 AA251850 BM129287 AA298571
GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for CNOT2 (see all 7) About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9a | · | 9b | · | 9c | ^ | 10a | · | 10b | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15a | · | 15b | ^ | 16 | ^ | 17 |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | - | | - | | | | - | | | | - | | | | | | | | | | | | | | | | - | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | - | | - | | | | | | | | | | | | - | | - | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for CNOT2
|
Expression
for CNOT2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CNOT2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAGCCAACAA
About this image
See CNOT2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CNOT2
SOURCE GeneReport for Unigene cluster: Hs.133350
UniProtKB/Swiss-Prot: CNOT2_HUMAN, Q9NZN8Tissue specificity: Ubiquitous. Highly expressed in brain, heart, thymus, spleen, kidney, liver, small intestine,placenta, lung and peripheral blood leukocytes
SABiosciences Custom PCR Arrays for CNOT2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CNOT2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CNOT2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CNOT2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CNOT2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CNOT2 |
Orthologs
for CNOT2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for CNOT2 gene from 10/36 species (see all 36) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Cnot21 , 5 |
CCR4-NOT transcription complex, subunit 21, 5 |
95.43(n)1
99.81(a)1 |
|
10 (64.76 cM)5
720681 NM_001037846.31 NP_001032935.21
1164851655 |
chicken
(Gallus gallus) |
Aves |
CNOT21 |
CCR4-NOT transcription complex, subunit 2 |
93.72(n)
99.23(a) |
|
417851 NM_001012808.1 NP_001012826.1 |
lizard
(Anolis carolinensis) |
Reptilia |
CNOT26 |
-- |
96(a) |
1 ↔ 1 |
GL343256.1(1913231-1935119) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.133122 |
Xenopus laevis transcribed sequence with moderate similarity more |
88.73(n) |
|
BU910022.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
570957312 |
-- |
82.23(n) |
|
57095731 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Rga1 , 3 |
Regena1 |
54(a)3
47.81(n)1
43.65(a)1 |
|
3 83B53
406831 NM_079515.21 NP_524239.21 |
worm
(Caenorhabditis elegans) |
Secernentea |
B0286.4c3 |
-- |
47(a)
(best of 3) |
|
II(4372945-4374492) -- |
baker's yeast
(Saccharomyces cerevisiae) |
Saccharomycetes |
CDC36(YDL165W)4
CDC361 |
Component of the CCR4-NOT complex, which has multiple more4
Cdc36p1 |
46.18(n)1
33.13(a)1 |
|
4(164290-164865)4
8513891, 4 NP_010116.11, 4 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
AT1G077051 |
CCR4-NOT transcription complex subunit 2 |
48.15(n)
43.1(a) |
|
837284 NM_001084009.1 NP_001077478.1 |
rice
(Oryza sativa) |
Liliopsida |
Os.118622 |
Oryza sativa (japonica cultivar-group) cDNA clone0 more |
73.88(n) |
|
AK099785.1 |
ENSEMBL Gene Tree for CNOT2 (if available)
TreeFam Gene Tree for CNOT2 (if available) |
Paralogs
for CNOT2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for CNOT2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 12 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CNOT2 (70636774 - 70748773 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for CNOT2
1 CNV: 66262 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CNOT2 |
|
Disorders
/ Diseases
for CNOT2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CNOT2 for disorders About GeneDecksing
OMIM gene information: 604909
OMIM disorders: --
1  disease for CNOT2: About MalaCardsmalaria
Human Genome Epidemiology (HuGE) Navigator: CNOT2 (1 document)
Export disorders for CNOT2 gene to outside databases
|
Publications
for CNOT2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CNOT2 gene, integrated from 9 sources (see all 28):
(articles sorted by number of sources associating them with CNOT2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Isolation and characterization of human orthologs of yeast CCR4-NOT complex subunits. (PubMed id 10637334)1, 2, 3 Albert T.K....Timmers H.T. (2000)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2 Zhang Q.-H.... Chen Z. (2000)
- The cyclin-dependent kinase 11 interacts with NOT2. (PubMed id 16039607)1, 9 Shi J. and Nelson M.A. (2005)
- Involvement of the SMRT/NCoR-HDAC3 complex in transcriptional repression by the CNOT2 subunit of the human Ccr4-Not complex. (PubMed id 16712523)1, 9 Jayne S....Timmers H.T. (2006)
- Cnot1, Cnot2, and Cnot3 maintain mouse and human ESC i dentity and inhibit extraembryonic differentiation. (PubMed id 22367759)1 Zheng X....Hu G. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- CNOT2 depletion disrupts and inhibits the CCR4-NOT de adenylase complex and induces apoptotic cell death. (PubMed id 21299754)1 Ito K....Yamamoto T. (2011)
|
External Searches for CNOT2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CNOT2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CNOT2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CNOT2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for CNOT2 gene:
Search GeneIP for patents involving CNOT2
GeneCards and IP:
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Products
for CNOT2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for CNOT2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CNOT2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CNOT2 | | | OriGene Protein Over-expression Lysate for CNOT2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CNOT2 | | OriGene 3'-UTR Clone for CNOT2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CNOT2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CNOT2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for CNOT2 | | OriGene Custom Protein Services for CNOT2 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CNOT2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CNOT2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CNOT2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CNOT2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CNOT2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CNOT2 |
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| | Antibodies & Assays for CNOT2 (NOT2) |
| | | | Search Tocris compounds for CNOT2 |
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 | | | CNOT2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CNOT2 |
|  |  |  | | | | Search ThermoFisher Antibodies for CNOT2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CNOT2 |
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