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Aliases for CNOT2 Gene

Aliases for CNOT2 Gene

  • CCR4-NOT Transcription Complex Subunit 2 2 3 5
  • CCR4-NOT Transcription Complex, Subunit 2 2 3
  • CCR4-Associated Factor 2 3 4
  • CDC36 3 4
  • NOT2 3 4
  • Negative Regulator Of Transcription 2 3
  • HSPC131 3
  • NOT2H 3

External Ids for CNOT2 Gene

Previous HGNC Symbols for CNOT2 Gene

  • NOT2

Previous GeneCards Identifiers for CNOT2 Gene

  • GC12P070508
  • GC12P070353
  • GC12P068923
  • GC12P070636
  • GC12P067686

Summaries for CNOT2 Gene

Entrez Gene Summary for CNOT2 Gene

  • This gene encodes a subunit of the multi-component CCR4-NOT complex. The CCR4-NOT complex regulates mRNA synthesis and degradation and is also thought to be involved in mRNA splicing, transport and localization. The encoded protein interacts with histone deacetylases and functions as a repressor of polymerase II transcription. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2010]

GeneCards Summary for CNOT2 Gene

CNOT2 (CCR4-NOT Transcription Complex Subunit 2) is a Protein Coding gene. Diseases associated with CNOT2 include space motion sickness. Among its related pathways are Gene Expression and Regulation of TP53 Activity. GO annotations related to this gene include RNA polymerase II transcription cofactor activity and RNA polymerase II transcription corepressor binding.

UniProtKB/Swiss-Prot for CNOT2 Gene

  • Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Required for the CCR4-NOT complex structural integrity. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may specificly involve the N-Cor repressor complex containing HDAC3, NCOR1 and NCOR2. Involved in the maintenance of emryonic stem (ES) cell identity.

Gene Wiki entry for CNOT2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CNOT2 Gene

Genomics for CNOT2 Gene

Regulatory Elements for CNOT2 Gene

Promoters for CNOT2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CNOT2 on UCSC Golden Path with GeneCards custom track

Genomic Location for CNOT2 Gene

Chromosome:
12
Start:
70,242,994 bp from pter
End:
70,354,993 bp from pter
Size:
112,000 bases
Orientation:
Plus strand

Genomic View for CNOT2 Gene

Genes around CNOT2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CNOT2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CNOT2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CNOT2 Gene

Proteins for CNOT2 Gene

  • Protein details for CNOT2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NZN8-CNOT2_HUMAN
    Recommended name:
    CCR4-NOT transcription complex subunit 2
    Protein Accession:
    Q9NZN8
    Secondary Accessions:
    • Q9H3E0
    • Q9NSX5
    • Q9NWR6
    • Q9P028

    Protein attributes for CNOT2 Gene

    Size:
    540 amino acids
    Molecular mass:
    59738 Da
    Quaternary structure:
    • Component of the CCR4-NOT complex; distinct complexes seem to exist that differ in the participation of probably mutually exclusive catalytic subunits. In the complex interacts directly with CNOT3. Interacts with NCOR1, NCOR2. HDAC3 and GPS2.
    SequenceCaution:
    • Sequence=AAF29095.1; Type=Frameshift; Positions=474; Evidence={ECO:0000305}; Sequence=AAQ13426.1; Type=Frameshift; Positions=71, 76, 84, 98, 123, 370, 384, 393; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CNOT2 Gene

    Alternative splice isoforms for CNOT2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CNOT2 Gene

Proteomics data for CNOT2 Gene at MOPED

Post-translational modifications for CNOT2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CNOT2 (NOT2)

No data available for DME Specific Peptides for CNOT2 Gene

Domains & Families for CNOT2 Gene

Gene Families for CNOT2 Gene

Protein Domains for CNOT2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for CNOT2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NZN8

UniProtKB/Swiss-Prot:

CNOT2_HUMAN :
  • Belongs to the CNOT2/3/5 family.
Family:
  • Belongs to the CNOT2/3/5 family.
genes like me logo Genes that share domains with CNOT2: view

Function for CNOT2 Gene

Molecular function for CNOT2 Gene

UniProtKB/Swiss-Prot Function:
Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Required for the CCR4-NOT complex structural integrity. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may specificly involve the N-Cor repressor complex containing HDAC3, NCOR1 and NCOR2. Involved in the maintenance of emryonic stem (ES) cell identity.
genes like me logo Genes that share phenotypes with CNOT2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CNOT2

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CNOT2 Gene

Localization for CNOT2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CNOT2 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CNOT2 Gene COMPARTMENTS Subcellular localization image for CNOT2 gene
Compartment Confidence
cytosol 5
nucleus 5
plasma membrane 2
cytoskeleton 1
endoplasmic reticulum 1
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CNOT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 21299754
genes like me logo Genes that share ontologies with CNOT2: view

Pathways & Interactions for CNOT2 Gene

genes like me logo Genes that share pathways with CNOT2: view

Gene Ontology (GO) - Biological Process for CNOT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 14707134
GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IBA,TAS --
GO:0001829 trophectodermal cell differentiation IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter NAS 10637334
genes like me logo Genes that share ontologies with CNOT2: view

No data available for SIGNOR curated interactions for CNOT2 Gene

Drugs & Compounds for CNOT2 Gene

No Compound Related Data Available

Transcripts for CNOT2 Gene

Unigene Clusters for CNOT2 Gene

CCR4-NOT transcription complex, subunit 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CNOT2 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17
SP1: - - - - -
SP2: -
SP3:
SP4: - - - - - - - -
SP5:
SP6: - -
SP7: -

Relevant External Links for CNOT2 Gene

GeneLoc Exon Structure for
CNOT2
ECgene alternative splicing isoforms for
CNOT2

Expression for CNOT2 Gene

mRNA expression in normal human tissues for CNOT2 Gene

Protein differential expression in normal tissues from HIPED for CNOT2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (11.0), Testis (9.4), and Bone (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CNOT2 Gene



SOURCE GeneReport for Unigene cluster for CNOT2 Gene Hs.133350

mRNA Expression by UniProt/SwissProt for CNOT2 Gene

Q9NZN8-CNOT2_HUMAN
Tissue specificity: Ubiquitous. Highly expressed in brain, heart, thymus, spleen, kidney, liver, small intestine, placenta, lung and peripheral blood leukocytes.
genes like me logo Genes that share expression patterns with CNOT2: view

Protein tissue co-expression partners for CNOT2 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for CNOT2 Gene

Orthologs for CNOT2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CNOT2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CNOT2 35
  • 96.9 (n)
  • 96.02 (a)
CNOT2 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CNOT2 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CNOT2 36
  • 100 (a)
OneToOne
CNOT2 35
  • 98.64 (n)
  • 100 (a)
mouse
(Mus musculus)
Mammalia Cnot2 16
Cnot2 36
  • 100 (a)
OneToOne
Cnot2 35
  • 95.43 (n)
  • 99.81 (a)
oppossum
(Monodelphis domestica)
Mammalia CNOT2 36
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CNOT2 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cnot2 35
  • 95.25 (n)
  • 99.77 (a)
chicken
(Gallus gallus)
Aves CNOT2 36
  • 99 (a)
OneToOne
CNOT2 35
  • 93.72 (n)
  • 99.23 (a)
lizard
(Anolis carolinensis)
Reptilia CNOT2 36
  • 85 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.13312 35
tropical clawed frog
(Silurana tropicalis)
Amphibia cnot2 35
  • 88.46 (n)
  • 96.54 (a)
Str.5823 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13407 35
zebrafish
(Danio rerio)
Actinopterygii cnot2 35
  • 79.05 (n)
  • 88.59 (a)
cnot2 36
  • 88 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Rga 37
  • 54 (a)
CG15262 36
  • 21 (a)
OneToMany
CG6576 36
  • 27 (a)
OneToMany
Rga 36
  • 31 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea B0286.4a 37
  • 43 (a)
B0286.4b 37
  • 45 (a)
B0286.4c 37
  • 47 (a)
ntl-2 36
  • 32 (a)
OneToMany
tag-153 36
  • 16 (a)
OneToMany
ntl-2 35
  • 49.41 (n)
  • 43.77 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACL151C 35
  • 44.98 (n)
  • 36.14 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CDC36 35
  • 46.79 (n)
  • 33.73 (a)
CDC36 36
  • 34 (a)
OneToOne
CDC36 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D12408g 35
  • 47.39 (n)
  • 33.13 (a)
corn
(Zea mays)
Liliopsida Zm.3513 35
rice
(Oryza sativa)
Liliopsida Os.11862 35
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes not2 35
  • 46.13 (n)
  • 37.05 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2536 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8375 36
  • 29 (a)
OneToMany
CSA.8562 36
  • 76 (a)
OneToMany
Species with no ortholog for CNOT2:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CNOT2 Gene

ENSEMBL:
Gene Tree for CNOT2 (if available)
TreeFam:
Gene Tree for CNOT2 (if available)

Paralogs for CNOT2 Gene

genes like me logo Genes that share paralogs with CNOT2: view

No data available for Paralogs for CNOT2 Gene

Variants for CNOT2 Gene

Sequence variations from dbSNP and Humsavar for CNOT2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs11178192 - 70,344,215(+) TTTTA(A/G)CTGCA nc-transcript-variant, reference, missense
rs788378 -- 70,330,452(+) CGACA(A/G)CCTTT intron-variant, nc-transcript-variant, reference, synonymous-codon
rs788379 -- 70,349,619(+) TTTCT(C/T)ATCCT intron-variant
rs1057499 -- 70,328,629(+) AAAAC(C/T)CAGGA intron-variant
rs2272180 -- 70,330,227(+) ATTTA(A/T)AGAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CNOT2 Gene

Variant ID Type Subtype PubMed ID
esv1061540 CNV Insertion 17803354
dgv292n67 CNV Loss 20364138
esv267925 CNV Insertion 20981092
esv25808 CNV Loss 19812545
nsv826415 CNV Loss 20364138
nsv899235 CNV Gain 21882294
dgv1445n71 CNV Gain+Loss 21882294
dgv1446n71 CNV Loss 21882294

Variation tolerance for CNOT2 Gene

Residual Variation Intolerance Score: 22.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.62; 13.30% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CNOT2 Gene

HapMap Linkage Disequilibrium report
CNOT2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CNOT2 Gene

Disorders for CNOT2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CNOT2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
space motion sickness
- elite association - COSMIC cancer census association via MalaCards
Search CNOT2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CNOT2

Genetic Association Database (GAD)
CNOT2
Human Genome Epidemiology (HuGE) Navigator
CNOT2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CNOT2
genes like me logo Genes that share disorders with CNOT2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CNOT2 Gene

Publications for CNOT2 Gene

  1. Isolation and characterization of human orthologs of yeast CCR4-NOT complex subunits. (PMID: 10637334) Albert T.K. … Timmers H.T.M. (Nucleic Acids Res. 2000) 2 3 4 67
  2. Involvement of the SMRT/NCoR-HDAC3 complex in transcriptional repression by the CNOT2 subunit of the human Ccr4-Not complex. (PMID: 16712523) Jayne S. … Timmers H.T. (Biochem. J. 2006) 3 23
  3. The cyclin-dependent kinase 11 interacts with NOT2. (PMID: 16039607) Shi J. … Nelson M.A. (Biochem. Biophys. Res. Commun. 2005) 3 23
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3

Products for CNOT2 Gene

Sources for CNOT2 Gene

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