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CNOT11 Gene

protein-coding   GIFtS: 39
GCID: GC02P101870

CCR4-NOT Transcription Complex, Subunit 11

(Previous name: chromosome 2 open reading frame 29)
(Previous symbol: C2orf29)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
CCR4-NOT Transcription Complex, Subunit 111 2
C2orf291 2 3
Chromosome 2 Open Reading Frame 291
CCR4-NOT Transcription Complex Subunit 112
UPF0760 Protein C2orf292

External Ids:    HGNC: 252171   Entrez Gene: 555712   Ensembl: ENSG000001584357   UniProtKB: Q9UKZ13   

Export aliases for CNOT11 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CNOT11 Gene:
CNOT11 (CCR4-NOT transcription complex, subunit 11) is a protein-coding gene.

UniProtKB/Swiss-Prot: CNO11_HUMAN, Q9UKZ1
Function: Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to
various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression
during translational initiation and general transcription regulation. Additional complex functions may be a
consequence of its influence on mRNA expression. Is required for the association of CNOT10 with the CCR4-NOT
complex. Seems not to be required for complex deadenylase function




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Search for regulatory transcription factor binding sites for CNOT11
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for CNOT11

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CNOT11


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q11.2   Ensembl cytogenetic band:  2q11.2   HGNC cytogenetic band: 2q12.1

CNOT11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CNOT11 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P101870:  view genomic region     (about GC identifiers)

Start:
101,869,264 bp from pter      End:
101,886,778 bp from pter
Size:
17,515 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CNO11_HUMAN, Q9UKZ1 (See protein sequence)
Recommended Name: CCR4-NOT transcription complex subunit 11  
Size: 510 amino acids; 55215 Da
Subunit: Component of the CCR4-NOT complex; distinct complexes seem to exist that differ in the participation of
probably mutually exclusive catalytic subunits. CNOT10 and CNOT11 form a subcomplex docked to the CNOT1 scaffold
Secondary accessions: Q6P2M9 Q8N681

Explore the universe of human proteins at neXtProt for CNOT11: NX_Q9UKZ1

Explore proteomics data for CNOT11 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys335, Lys495
  • Modification sites at PhosphoSitePlus

  • See CNOT11 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_060016.3  
    ENSEMBL proteins: 
     ENSP00000289382   ENSP00000394203  
    Reactome Protein details: Q9UKZ1

    CNOT11 Human Recombinant Protein Products:

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    Browse Proteins at Cloud-Clone Corp.

     
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    antibodies-online proteins for CNOT11 

     
    antibodies-online peptides for CNOT11

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    antibodies-online antibodies for CNOT11 (16 products) 

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    Browse ELISAs at Cloud-Clone Corp.
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    antibodies-online kits for CNOT11 (2 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR019312 DUF2363

    Graphical View of Domain Structure for InterPro Entry Q9UKZ1

    ProtoNet protein and cluster: Q9UKZ1

    UniProtKB/Swiss-Prot: CNO11_HUMAN, Q9UKZ1
    Similarity: Belongs to the CNOT11 family


    Find genes that share domains with CNOT11           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CNO11_HUMAN, Q9UKZ1
    Function: Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to
    various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression
    during translational initiation and general transcription regulation. Additional complex functions may be a
    consequence of its influence on mRNA expression. Is required for the association of CNOT10 with the CCR4-NOT
    complex. Seems not to be required for complex deadenylase function

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0005515protein binding IPI--
         
    Find genes that share ontologies with CNOT11           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for CNOT11

    miRNA
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    miRTarBase miRNAs that target CNOT11:
    hsa-mir-196a-5p (MIRT048199), hsa-mir-149-5p (MIRT045470), hsa-mir-25-3p (MIRT050217), hsa-mir-124-3p (MIRT023186)

    Block miRNA regulation of human, mouse, rat CNOT11 using miScript Target Protectors
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    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CNOT11

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CNO11_HUMAN, Q9UKZ1: Cytoplasm (Probable). Nucleus (Probable)

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005829cytosol TAS--
    GO:0030014CCR4-NOT complex IDA19558367

    Find genes that share ontologies with CNOT11           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CNOT11 About    
    See pathways by source

    SuperPathContained pathways About
    1Deadenylation-dependent mRNA decay
    Deadenylation-dependent mRNA decay0.48
    Deadenylation of mRNA0.48
    2Gene Expression
    Gene Expression0.40


    Find genes that share SuperPaths with CNOT11           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for CNOT11
        Deadenylation of mRNA


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CNOT11
    Interactions:

        Search GeneGlobe Interaction Network for CNOT11

    STRING Interaction Network Preview (showing 5 interactants - click image to see 20)

    Selected Interacting proteins for CNOT11 (Q9UKZ11, 3 ENSP000002893824) via UniProtKB, MINT, STRING, and/or I2D (see all 21)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MYCP011063, ENSP000003672074I2D: score=1 STRING: ENSP00000367207
    CNOT1A5YKK61, ENSP000003209494STRING: ENSP00000320949 EBI-2562014,EBI-1222758
    CNOT10Q9H9A51, ENSP000003300604EBI-2562014,EBI-1054261 STRING: ENSP00000330060
    CNOT2ENSP000002291954STRING: ENSP00000229195
    CNOT3ENSP000002212324STRING: ENSP00000221232
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000288nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay TAS--
    GO:0000289nuclear-transcribed mRNA poly(A) tail shortening TAS--
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--
    GO:0006417regulation of translation IEA--

    Find genes that share ontologies with CNOT11           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CNOT11 (CNO11)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CNOT11 gene: 
    NM_017546.4  

    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000289382(uc002taw.4) ENST00000462489 ENST00000420107
    miRNA
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    Primer
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      QuantiFast Probe-based Assays in human, mouse, rat CNOT11

    Selected AceView cDNA sequences (see all 249):

    AA524263 BE879472 BM828321 AI140642 CA432565 CD724078 BQ774906 BI092598 
    BM973958 AA309758 AW243559 CB267910 AA280796 AA515378 CA307178 BQ774828 
    AK024221 BM923954 AW130072 BE350932 AI950980 AA290988 CB215610 BC018664 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for CNOT11    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b
    SP1:              -                                                   
    SP2:                                                                  
    SP3:                                                                  


    ECgene alternative splicing isoforms for CNOT11

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CNOT11 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CNOT11 Expression
    About this image

    CNOT11 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CNOT11 Protein Expression
        Custom PCR Arrays for CNOT11
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CNOT11 gene from Selected species (see all 24)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cnot111 , 5 DNA segment, Chr 1, Brigham & Women's Genetics 0212 more5
    CCR4-NOT transcription complex, subunit 111
    88.05(n)1
    93.66(a)1
      1 (18.31 cM)5
    528461  NM_028043.21  NP_082319.11 
     395349925 
    chicken
    (Gallus gallus)
    Aves C2ORF291 chromosome 1 open reading frame, human C2orf29 83.11(n)
    94.42(a)
      418711  XM_416910.4  XP_416910.3 
    lizard
    (Anolis carolinensis)
    Reptilia CNOT116
    CCR4-NOT transcription complex, subunit 11
    94(a)
    1 ↔ 1
    GL343542.1(138426-153543)
    African clawed frog
    (Xenopus laevis)
    Amphibia BJ619677.12   -- 81.81(n)    BJ619677.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufj49e012 Transcribed sequence with moderate similarity to protein more 75.79(n)    CK127695.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG135671 CG13567 59.38(n)
    62.33(a)
      37839  NM_138030.3  NP_611874.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G184201 AT5G18420 51.11(n)
    45.13(a)
      831960  NM_180514.3  NP_850845.1 
    rice
    (Oryza sativa)
    Liliopsida AK059540.12   -- 73.26(n)    AK059540.1 


    ENSEMBL Gene Tree for CNOT11 (if available)
    TreeFam Gene Tree for CNOT11 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CNOT11 (see all 442)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs111238671,2
    C,F,A--101867359(+) CCACCG/TTGCCC 1 -- us2k11Minor allele frequency- T:0.50WA 2
    rs99738291,2
    C,F--101867414(+) TGAATC/TAGTTC 1 -- us2k11Minor allele frequency- T:0.20WA 118
    rs1865980351,2
    --101867508(+) AGAAGC/GCTTTA 1 -- us2k10--------
    rs1923505211,2
    C--101867522(+) TTCAGC/TAGATA 1 -- us2k10--------
    rs1151528481,2
    C,F--101867533(+) TCACAC/ACTGTT 1 -- us2k11Minor allele frequency- A:0.01WA 118
    rs1830053751,2
    --101867563(+) CTTAAA/TTTTTT 1 -- us2k10--------
    rs1140159651,2
    C,F--101867570(+) TTTTCA/TTAAGA 1 -- us2k11Minor allele frequency- T:0.02WA 118
    rs1879609001,2
    --101867613(+) AGTGGC/GAGCTA 1 -- us2k10--------
    rs1929844461,2
    --101867628(+) ATGAGA/GATGCA 1 -- us2k10--------
    rs1475330601,2
    --101867738(+) TCACGC/TGCGTC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CNOT11 (101869264 - 101886778 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for CNOT11: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CNOT11
    DNA2.0 Custom Variant and Variant Library Synthesis for CNOT11

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CNOT11 gene, integrated from 10 sources (see all 18):
    (articles sorted by number of sources associating them with CNOT11)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. C2ORF29/CNOT11 and CNOT10 form a new module of the CCR4-NOT complex. (PubMed id 23232451)1, 2, 3 Mauxion F.... Seraphin B. (RNA Biol. 2013)
    2. NOT10 and C2orf29/NOT11 form a conserved module of the CCR4-NOT complex that docks onto the NOT1 N-terminal domain. (PubMed id 23303381)1, 2, 3 Bawankar P.... Izaurralde E. (RNA Biol. 2013)
    3. Identification of differentially expressed genes associated with HER- 2/neu overexpression in human breast cancer cells. (PubMed id 10497265)1, 2, 3 Oh J.J.... Slamon D.J. (Nucleic Acids Res. 1999)
    4. Human Ccr4-Not complexes contain variable deadenylase subunits. (PubMed id 19558367)1, 2 Lau N.C.... Timmers H.T. (Biochem. J. 2009)
    5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W.... Wilson R.K. (Nature 2005)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    8. The protein interaction landscape of the human CMGC kinase group. (PubMed id 23602568)1 Varjosalo M....Gstaiger M. (Cell Rep 2013)
    9. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55571 HGNC: 25217 AceView: C2orf29 Ensembl:ENSG00000158435 euGenes: HUgn55571
    ECgene: CNOT11 H-InvDB: CNOT11

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CNOT11 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for CNOT11 gene:
    Search GeneIP for patents involving CNOT11

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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    About This Section

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