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Aliases for CNOT11 Gene

Aliases for CNOT11 Gene

  • CCR4-NOT Transcription Complex, Subunit 11 2 3
  • C2orf29 3 4
  • CCR4-NOT Transcription Complex Subunit 11 3
  • Chromosome 2 Open Reading Frame 29 2
  • UPF0760 Protein C2orf29 3
  • C40 3

External Ids for CNOT11 Gene

Previous Symbols for CNOT11 Gene

  • C2orf29

Summaries for CNOT11 Gene

GeneCards Summary for CNOT11 Gene

CNOT11 (CCR4-NOT Transcription Complex, Subunit 11) is a Protein Coding gene. Among its related pathways are Gene Expression and Deadenylation-dependent mRNA decay.

UniProtKB/Swiss-Prot for CNOT11 Gene

  • Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Is required for the association of CNOT10 with the CCR4-NOT complex. Seems not to be required for complex deadenylase function

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CNOT11 Gene

Genomics for CNOT11 Gene

Genomic Location for CNOT11 Gene

Start:
101,252,802 bp from pter
End:
101,270,316 bp from pter
Size:
17,515 bases
Orientation:
Plus strand

Genomic View for CNOT11 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CNOT11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CNOT11 Gene

No data available for Regulatory Elements for CNOT11 Gene

Proteins for CNOT11 Gene

  • Protein details for CNOT11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UKZ1-CNO11_HUMAN
    Recommended name:
    CCR4-NOT transcription complex subunit 11
    Protein Accession:
    Q9UKZ1
    Secondary Accessions:
    • Q6P2M9
    • Q8N681

    Protein attributes for CNOT11 Gene

    Size:
    510 amino acids
    Molecular mass:
    55215 Da
    Quaternary structure:
    • Component of the CCR4-NOT complex; distinct complexes seem to exist that differ in the participation of probably mutually exclusive catalytic subunits. CNOT10 and CNOT11 form a subcomplex docked to the CNOT1 scaffold.

neXtProt entry for CNOT11 Gene

Proteomics data for CNOT11 Gene at MOPED

Post-translational modifications for CNOT11 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys335 and Lys495

Other Protein References for CNOT11 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for CNOT11 Gene

Domains for CNOT11 Gene

Protein Domains for CNOT11 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

CNO11_HUMAN
Family:
  • Belongs to the CNOT11 family.:
    • Q9UKZ1
genes like me logo Genes that share domains with CNOT11: view

No data available for Gene Families for CNOT11 Gene

Function for CNOT11 Gene

Molecular function for CNOT11 Gene

UniProtKB/Swiss-Prot Function: Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Is required for the association of CNOT10 with the CCR4-NOT complex. Seems not to be required for complex deadenylase function

Gene Ontology (GO) - Molecular Function for CNOT11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 23232451
genes like me logo Genes that share ontologies with CNOT11: view

miRNA for CNOT11 Gene

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for CNOT11 Gene

Localization for CNOT11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CNOT11 Gene

Cytoplasm. Nucleus.

Gene Ontology (GO) - Cellular Components for CNOT11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005829 cytosol TAS --
GO:0030014 CCR4-NOT complex IDA 19558367
genes like me logo Genes that share ontologies with CNOT11: view

Pathways for CNOT11 Gene

genes like me logo Genes that share pathways with CNOT11: view

Pathways by source for CNOT11 Gene

Gene Ontology (GO) - Biological Process for CNOT11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay TAS --
GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening TAS --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006417 regulation of translation IEA --
genes like me logo Genes that share ontologies with CNOT11: view

Transcripts for CNOT11 Gene

mRNA/cDNA for CNOT11 Gene

Unigene Clusters for CNOT11 Gene

CCR4-NOT transcription complex, subunit 11:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CNOT11 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b
SP1: -
SP2:
SP3:

Relevant External Links for CNOT11 Gene

GeneLoc Exon Structure for
CNOT11
ECgene alternative splicing isoforms for
CNOT11

Expression for CNOT11 Gene

mRNA expression in normal human tissues for CNOT11 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CNOT11 Gene

SOURCE GeneReport for Unigene cluster for CNOT11 Gene Hs.744080

genes like me logo Genes that share expressions with CNOT11: view

Orthologs for CNOT11 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CNOT11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CNOT11 36
  • 99.61 (n)
  • 99.41 (a)
CNOT11 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CNOT11 36
  • 87.32 (n)
  • 95.49 (a)
CNOT11 37
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CNOT11 36
  • 91.37 (n)
  • 96.86 (a)
CNOT11 37
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cnot11 36
  • 88.05 (n)
  • 93.66 (a)
Cnot11 16
Cnot11 37
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CNOT11 37
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CNOT11 37
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cnot11 36
  • 86.11 (n)
  • 93.65 (a)
chicken
(Gallus gallus)
Aves C2ORF29 36
  • 83.11 (n)
  • 94.42 (a)
CNOT11 37
  • 96 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CNOT11 37
  • 94 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cnot11 36
  • 78.48 (n)
  • 91.93 (a)
Str.18681 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.971 36
zebrafish
(Danio rerio)
Actinopterygii cnot11 36
  • 72.88 (n)
  • 85.84 (a)
cnot11 37
  • 86 (a)
OneToOne
wufj49e01 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007117 36
  • 49.52 (n)
  • 41.15 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG13567 36
  • 59.38 (n)
  • 62.33 (a)
CG13567 37
  • 54 (a)
OneToOne
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.5129 36
soybean
(Glycine max)
eudicotyledons Gma.17966 36
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G18420 36
  • 51.11 (n)
  • 45.13 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.10531 36
rice
(Oryza sativa)
Liliopsida Os11g0240900 36
  • 54.35 (n)
  • 51.23 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.4129 36
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.12100 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 54 (a)
OneToMany
CSA.605 37
  • 60 (a)
OneToMany
Species with no ortholog for CNOT11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • worm (Caenorhabditis elegans)

Evolution for CNOT11 Gene

ENSEMBL:
Gene Tree for CNOT11 (if available)
TreeFam:
Gene Tree for CNOT11 (if available)

Paralogs for CNOT11 Gene

No data available for Paralogs for CNOT11 Gene

Variants for CNOT11 Gene

Sequence variations from dbSNP and Humsavar for CNOT11 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs12114 -- 101,270,141(-) ATTTT(C/T)CCTTA utr-variant-3-prime
rs874272 -- 101,253,611(+) CTCTC(C/T)CTGCG intron-variant
rs881133 -- 101,254,747(-) AGCAA(A/T)TTTTT intron-variant
rs935067 -- 101,254,400(-) AGAAA(C/T)GCGGC intron-variant
rs1007752 -- 101,262,561(-) CTTTG(C/T)GTTGG synonymous-codon, reference

Relevant External Links for CNOT11 Gene

HapMap Linkage Disequilibrium report
CNOT11

No data available for Structural Variations from Database of Genomic Variants (DGV) for CNOT11 Gene

Disorders for CNOT11 Gene

No disorders were found for CNOT11 Gene.

No data available for UniProtKB/Swiss-Prot for CNOT11 Gene

Publications for CNOT11 Gene

  1. Identification of differentially expressed genes associated with HER- 2/neu overexpression in human breast cancer cells. (PMID: 10497265) Oh J.J. … Slamon D.J. (Nucleic Acids Res. 1999) 2 3 4
  2. C2ORF29/CNOT11 and CNOT10 form a new module of the CCR4-NOT complex. (PMID: 23232451) Mauxion F. … Seraphin B. (RNA Biol. 2013) 2 3 4
  3. NOT10 and C2orf29/NOT11 form a conserved module of the CCR4-NOT complex that docks onto the NOT1 N-terminal domain. (PMID: 23303381) Bawankar P. … Izaurralde E. (RNA Biol. 2013) 2 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4

Products for CNOT11 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate CNOT11
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for CNOT11
    • Block miRNA regulation of CNOT11 using miScript Target Protectors

    Sources for CNOT11 Gene

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