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CNOT10 Gene

protein-coding   GIFtS: 51
GCID: GC03P032727

CCR4-NOT Transcription Complex, Subunit 10

  Search for CNOT10
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
CCR4-NOT Transcription Complex, Subunit 101 2
CCR4-NOT Transcription Complex Subunit 102

External Ids:    HGNC: 238171   Entrez Gene: 259042   Ensembl: ENSG000001829737   UniProtKB: Q9H9A53   

Export aliases for CNOT10 gene to outside databases

Previous GC identifers: GC03P032698 GC03P032701


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CNOT10 Gene:
CNOT10 (CCR4-NOT transcription complex, subunit 10) is a protein-coding gene.

UniProtKB/Swiss-Prot: CNO10_HUMAN, Q9H9A5
Function: Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to
various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression
during translational initiation and general transcription regulation. Additional complex functions may be a
consequence of its influence on mRNA expression. Is not required for association of CNOT7 to the CCR4-NOT complex




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NT_022517.19  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CNOT10 gene promoter:
         AhR   SREBP-1c   p300   Arnt   c-Ets-1   SREBP-1b   Pax-3   SREBP-1a   Ik-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCNOT10 promoter sequence
   Search Chromatin IP Primers for CNOT10

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CNOT10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p22.3   Ensembl cytogenetic band:  3p22.3   HGNC cytogenetic band: 3p23

CNOT10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CNOT10 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P032727:  view genomic region     (about GC identifiers)

Start:
32,726,637 bp from pter      End:
32,815,367 bp from pter
Size:
88,731 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CNO10_HUMAN, Q9H9A5 (See protein sequence)
Recommended Name: CCR4-NOT transcription complex subunit 10  
Size: 744 amino acids; 82310 Da
Subunit: Component of the CCR4-NOT complex; distinct complexes seem to exist that differ in the participation of
probably mutually exclusive catalytic subunits. CNOT10 and CNOT11 form a subcomplex docked to the CNOT1 scaffold
Sequence caution: Sequence=BAB13876.1; Type=Erroneous initiation;
Secondary accessions: B7Z7L1 F8WAF2 Q9BU30 Q9H5J7 Q9H8X1 Q9H9W0 Q9HAH3 Q9UFJ2
Alternative splicing: 6 isoforms:  Q9H9A5-1   Q9H9A5-2   Q9H9A5-3   Q9H9A5-4   Q9H9A5-5   Q9H9A5-6   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CNOT10: NX_Q9H9A5

Explore proteomics data for CNOT10 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys74, Lys256, Lys271, Lys404
  • Modification sites at PhosphoSitePlus

  • See CNOT10 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001243670.1  NP_001243671.1  NP_056257.1  

    ENSEMBL proteins: 
     ENSP00000329376   ENSP00000330060   ENSP00000402795   ENSP00000402979   ENSP00000392312  
     ENSP00000395385   ENSP00000399862   ENSP00000442552  
    Reactome Protein details: Q9H9A5

    CNOT10 Human Recombinant Protein Products:

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    Novus Biologicals CNOT10 Protein
    Novus Biologicals CNOT10 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CNOT10

     
    Search eBioscience for Proteins for CNOT10 

    CNOT10 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    LSBio Antibodies in human, mouse, rat for CNOT10

    CNOT10 Assay Products:

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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CNOT10
    Cloud-Clone Corp. CLIAs for CNOT10
    Search eBioscience for ELISAs for CNOT10 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    TTC: Tetratricopeptide (TTC) repeat domain containing

    3 InterPro protein domains:
     IPR011990 TPR-like_helical
     IPR001440 TPR_1
     IPR019734 TPR_repeat

    Graphical View of Domain Structure for InterPro Entry Q9H9A5

    ProtoNet protein and cluster: Q9H9A5

    UniProtKB/Swiss-Prot: CNO10_HUMAN, Q9H9A5
    Similarity: Belongs to the CNOT10 family


    Find genes that share domains with CNOT10           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CNO10_HUMAN, Q9H9A5
    Function: Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to
    various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression
    during translational initiation and general transcription regulation. Additional complex functions may be a
    consequence of its influence on mRNA expression. Is not required for association of CNOT7 to the CCR4-NOT complex

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
         
    Find genes that share ontologies with CNOT10           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for CNOT10:
     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CNOT10
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CNOT10
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CNOT10

    miRNA
    Products:
        
    miRTarBase miRNAs that target CNOT10:
    hsa-mir-155-5p (MIRT020673), hsa-mir-615-3p (MIRT039734)

    Block miRNA regulation of human, mouse, rat CNOT10 using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate CNOT10:
    hsa-miR-4307 hsa-miR-4328 hsa-miR-194 hsa-miR-590-3p
    SwitchGear 3'UTR luciferase reporter plasmidCNOT10 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CNOT10

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: CNOT10 (NM_015442)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CNOT10
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CNOT10

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CNOT10


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CNO10_HUMAN, Q9H9A5: Cytoplasm (Probable). Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus4

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005829cytosol TAS--
    GO:0030014CCR4-NOT complex IDA19558367

    Find genes that share ontologies with CNOT10           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CNOT10 About    
    See pathways by source

    SuperPathContained pathways About
    1Deadenylation-dependent mRNA decay
    Deadenylation-dependent mRNA decay0.48
    Deadenylation of mRNA0.48
    RNA degradation0.48
    2Gene Expression
    Gene Expression0.40


    Find genes that share SuperPaths with CNOT10           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for CNOT10
        Deadenylation of mRNA


    1 Kegg Pathway  (Kegg details for CNOT10):
        RNA degradation

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CNOT10
    Interactions:

        Search GeneGlobe Interaction Network for CNOT10

    STRING Interaction Network Preview (showing 5 interactants - click image to see 21)

    Selected Interacting proteins for CNOT10 (Q9H9A51, 2, 3 ENSP000003300604) via UniProtKB, MINT, STRING, and/or I2D (see all 579)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    USP22Q9UPT93, ENSP000002614974I2D: score=2 STRING: ENSP00000261497
    TOB1P506163, ENSP000002689574I2D: score=1 STRING: ENSP00000268957
    CNOT11Q9UKZ11, ENSP000002893824EBI-1054261,EBI-2562014 STRING: ENSP00000289382
    CNOT6Q9ULM63, ENSP000002619514I2D: score=1 STRING: ENSP00000261951
    CNOT6LQ96LI53, ENSP000002649034I2D: score=1 STRING: ENSP00000264903
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000288nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay TAS--
    GO:0000289nuclear-transcribed mRNA poly(A) tail shortening TAS--
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--
    GO:0006417regulation of translation IEA--

    Find genes that share ontologies with CNOT10           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CNOT10 (CNO10)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CNOT10 gene (3 alternative transcripts): 
    NM_001256741.1  NM_001256742.1  NM_015442.2  

    Unigene Cluster for CNOT10:

    CCR4-NOT transcription complex, subunit 10
    Hs.444851  [show with all ESTs]
    Unigene Representative Sequence: NM_015442
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 20):
    ENST00000331889 ENST00000328834(uc003cfc.1 uc003cfd.1 uc003cfe.1 uc010hfv.1 uc010hfw.1)
    ENST00000435630 ENST00000556853 ENST00000494439 ENST00000463006 ENST00000485136
    ENST00000466103 ENST00000416457 ENST00000455381 ENST00000463697 ENST00000430408
    ENST00000471003 ENST00000481526 ENST00000479397 ENST00000468599 ENST00000473064
    ENST00000476967
    miRNA
    Products:
         
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    4 qRT-PCR Assays for microRNAs that regulate CNOT10:
    hsa-miR-4307 hsa-miR-4328 hsa-miR-194 hsa-miR-590-3p
    SwitchGear 3'UTR luciferase reporter plasmidCNOT10 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CNOT10
    Predesigned siRNA for gene silencing in human, mouse, rat CNOT10
    Clone
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    OriGene ORF clones in mouse, rat for CNOT10
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CNOT10 (NM_015442)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CNOT10
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CNOT10
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CNOT10
    OriGene qSTAR qPCR primer pairs in human, mouse for CNOT10
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CNOT10
      QuantiTect SYBR Green Assays in human, mouse, rat CNOT10
      QuantiFast Probe-based Assays in human, mouse, rat CNOT10

    Additional mRNA sequence: 

    AK021695.1 AK022576.1 AK022952.1 AK023227.1 AK027026.1 AK297085.1 AK298693.1 AK302196.1 
    AK309670.1 AL117639.1 BC002928.2 BC002931.2 BC006382.2 NR_046352.1 

    18 DOTS entries:

    DT.313512  DT.100818866  DT.100748365  DT.120842688  DT.75117183  DT.95161784  DT.95161799  DT.97854421 
    DT.436912  DT.92043754  DT.100818869  DT.92451038  DT.100818862  DT.120842489  DT.92451044  DT.120842496 
    DT.97804532  DT.97854424 

    Selected AceView cDNA sequences (see all 158):

    AK027026 BM785282 BC002931 CB143506 BM047318 BF026370 BM016085 BG116502 
    AK022952 AU141906 AL117639 BM675100 BQ954968 BU154123 BC006382 CA398165 
    W56244 BX106257 CA866920 AL602598 CA866661 CA443758 AL602616 BM766208 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CNOT10 (see all 12)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b ^ 17 ^
    SP1:                                                                                                                          -                                 
    SP2:                                                                                                                          -                                 
    SP3:                                                                                                                    -     -                                 
    SP4:                                                                                      -                                   -                                 
    SP5:                                                                                                                    -     -           -     -               

    ExUns: 18a · 18b ^ 19 ^ 20a · 20b ^ 21a · 21b · 21c · 21d
    SP1:  -           -     -                                 
    SP2:  -           -     -                                 
    SP3:  -           -     -                                 
    SP4:  -           -     -                                 
    SP5:  -           -     -                                 


    ECgene alternative splicing isoforms for CNOT10

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CNOT10 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAGATAAACT
    CNOT10 Expression
    About this image

    CNOT10 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CNOT10 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.444851
        Custom PCR Arrays for CNOT10
    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat CNOT10
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CNOT10

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CNOT10 gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cnot101 , 5 CCR4-NOT transcription complex, subunit 101, 5 88.39(n)1
    96.21(a)1
      9 (64.72 cM)5
    788931  NM_153585.51  NP_705813.21 
     1145858785 
    chicken
    (Gallus gallus)
    Aves CNOT101 CCR4-NOT transcription complex, subunit 10 82.32(n)
    92.27(a)
      420669  NM_001006364.2  NP_001006364.1 
    lizard
    (Anolis carolinensis)
    Reptilia CNOT106
    CCR4-NOT transcription complex, subunit 10
    90(a)
    1 ↔ 1
    1(193418519-193447473)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.81212 Xenopus laevis transcribed sequence with strong similarity more 80.1(n)    CF548914.1 
    zebrafish
    (Danio rerio)
    Actinopterygii 570477992   -- 75.46(n)    57047799 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG186161 CG18616 40.29(n)
    30.17(a)
      41552  NM_141958.3  NP_650215.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G354301 AT5G35430 44.41(n)
    32(a)
      833507  NM_122934.4  NP_198393.2 
    rice
    (Oryza sativa)
    Liliopsida Os09g01231001 Os09g0123100 43.73(n)
    32.91(a)
      4346428  NM_001069135.1  NP_001062600.1 


    ENSEMBL Gene Tree for CNOT10 (if available)
    TreeFam Gene Tree for CNOT10 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for CNOT10 (see all 2047)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1438322341,2
    --32657664(+) TACATA/GAATTA 3 -- us2k10--------
    rs1902818561,2
    --32657682(+) TTCACA/GTAATG 3 -- us2k10--------
    rs1472739431,2
    --32657709(+) AACAAC/TGAGAA 3 -- us2k10--------
    rs1809240881,2
    --32657840(+) TCCATA/GGTGTT 3 -- us2k10--------
    rs1858015251,2
    --32657951(+) ATATGC/TATGTG 3 -- us2k10--------
    rs1407769341,2
    --32657993(+) TATGAC/TTCATG 3 -- us2k10--------
    rs1499359051,2
    --32658070(+) TTTGAC/GACAGA 3 -- us2k10--------
    rs76168451,2
    C--32658372(+) TAAAAG/TAAAGT 3 -- us2k10--------
    rs1475129981,2
    C--32658391(+) AAAAA-/AGAAAA 3 -- us2k10--------
    rs1915728071,2
    --32658489(+) TGTAAA/CCATTA 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for CNOT10 (32726637 - 32815367 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for CNOT10:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1454338CNV Deletion17803354
    esv2515147CNV Deletion19546169
    esv2657972CNV Deletion23128226
    esv999127CNV Deletion20482838
    esv2725112CNV Deletion23290073
    nsv508908CNV Insertion20534489
    nsv237812CNV Loss16902084
    nsv513041CNV Loss21212237
    nsv822050CNV Loss20364138

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CNOT10 gene, integrated from 10 sources (see all 30):
    (articles sorted by number of sources associating them with CNOT10)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. C2ORF29/CNOT11 and CNOT10 form a new module of the CCR4-NOT complex. (PubMed id 23232451)1, 2 Mauxion F.... Seraphin B. (RNA Biol. 2013)
    2. NOT10 and C2orf29/NOT11 form a conserved module of the CCR4-NOT complex that docks onto the NOT1 N-terminal domain. (PubMed id 23303381)1, 2 Bawankar P.... Izaurralde E. (RNA Biol. 2013)
    3. Human Ccr4-Not complexes contain variable deadenylase subunits. (PubMed id 19558367)1, 2 Lau N.C.... Timmers H.T. (Biochem. J. 2009)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Protein interaction discovery using parallel analysis of translated ORFs (PLATO). (PubMed id 23503679)1 Zhu J....Elledge S.J. (Nat. Biotechnol. 2013)
    6. VCP phosphorylation-dependent interaction partners prevent apoptosis in Helicobacter pylori-infected gastric epithelial cells. (PubMed id 23383273)1 Yu C.C....Chow L.P. (PLoS ONE 2013)
    7. Trypanosome CNOT10 is essential for the integrity of the NOT deadenylase complex and for degradation of many mRNAs. (PubMed id 23221646)2 Farber V.... Clayton C. (Nucleic Acids Res. 2013)
    8. Identification of the hypoxia-inducible factor 2I+ nuclear interactome in melanoma cells reveals master proteins involved in melanoma development. (PubMed id 23275444)1 Steunou A.L....Nieto L. (amp 2013)
    9. Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. (PubMed id 24255178)1 Couzens A.L....Gingras A.C. (Sci Signal 2013)
    10. The HECT type ubiquitin ligase NEDL2 is degraded by anaphase-promoting complex/cyclosome (APC/C)-Cdh1, and its tight regulation maintains the metaphase to anaphase transition. (PubMed id 24163370)1 Lu L....Zhang L. (J. Biol. Chem. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 25904 HGNC: 23817 AceView: CNOT10 Ensembl:ENSG00000182973 euGenes: HUgn25904
    ECgene: CNOT10 Kegg: 25904 H-InvDB: CNOT10

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CNOT10 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for CNOT10 gene:
    Search GeneIP for patents involving CNOT10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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