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Aliases for CNOT10 Gene

Aliases for CNOT10 Gene

  • CCR4-NOT Transcription Complex Subunit 10 2 3 5
  • CCR4-NOT Transcription Complex, Subunit 10 2

External Ids for CNOT10 Gene

Previous GeneCards Identifiers for CNOT10 Gene

  • GC03P032698
  • GC03P032701

Summaries for CNOT10 Gene

GeneCards Summary for CNOT10 Gene

CNOT10 (CCR4-NOT Transcription Complex Subunit 10) is a Protein Coding gene. Among its related pathways are TP53 Regulates Transcription of Cell Cycle Genes and Deadenylation-dependent mRNA decay.

UniProtKB/Swiss-Prot for CNOT10 Gene

  • Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Is not required for association of CNOT7 to the CCR4-NOT complex.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CNOT10 Gene

Genomics for CNOT10 Gene

Regulatory Elements for CNOT10 Gene

Enhancers for CNOT10 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03F032706 0.2 Ensembl 12.4 +21.5 21456 0.8 POLR2A HMBOX1 CEBPB FOS CNOT10 CNOT10-AS1 SUGT1P2 TRIM71 TMPPE PIR58788
GH03F032778 1.3 FANTOM5 Ensembl ENCODE 11.7 +95.7 95686 4.1 CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZNF143 KLF13 SP5 REST TRIM71 SUGT1P2 CNOT10-AS1 CNOT10 ENSG00000236732 RPL23AP43
GH03F032708 0.2 ENCODE 11.5 +24.1 24080 0.8 HDAC1 PKNOX1 ATF1 ARNT TBL1XR1 SIN3A ZBTB40 CHAMP1 ZNF121 ELK1 CNOT10 CNOT10-AS1 SUGT1P2 TRIM71 RPL31P18 CMTM6 TMPPE PIR58788
GH03F032794 1.2 ENCODE 11.4 +109.7 109710 1.4 TBP MLX ARID4B THRB ZNF48 RAD21 RARA SLC30A9 GATA4 FOS DYNC1LI1 TRIM71 SUGT1P2 CNOT10-AS1 CNOT10 RPSAP11 RPL23AP43 GC03P032812
GH03F032888 0.3 FANTOM5 11.4 +203.3 203305 0.0 SUGT1P2 CNOT10-AS1 CNOT10 TRIM71 CMTM6 RPL31P18 PIR42638 PIR32571
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around CNOT10 on UCSC Golden Path with GeneCards custom track

Promoters for CNOT10 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001360640 355 2201 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A DMAP1 YY1 ZNF207 SP3

Genomic Location for CNOT10 Gene

Chromosome:
3
Start:
32,685,145 bp from pter
End:
32,773,875 bp from pter
Size:
88,731 bases
Orientation:
Plus strand

Genomic View for CNOT10 Gene

Genes around CNOT10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CNOT10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CNOT10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CNOT10 Gene

Proteins for CNOT10 Gene

  • Protein details for CNOT10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H9A5-CNO10_HUMAN
    Recommended name:
    CCR4-NOT transcription complex subunit 10
    Protein Accession:
    Q9H9A5
    Secondary Accessions:
    • B7Z7L1
    • F8WAF2
    • Q9BU30
    • Q9H5J7
    • Q9H8X1
    • Q9H9W0
    • Q9HAH3
    • Q9UFJ2

    Protein attributes for CNOT10 Gene

    Size:
    744 amino acids
    Molecular mass:
    82310 Da
    Quaternary structure:
    • Component of the CCR4-NOT complex; distinct complexes seem to exist that differ in the participation of probably mutually exclusive catalytic subunits. CNOT10 and CNOT11 form a subcomplex docked to the CNOT1 scaffold.
    SequenceCaution:
    • Sequence=BAB13876.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for CNOT10 Gene

neXtProt entry for CNOT10 Gene

Post-translational modifications for CNOT10 Gene

  • Ubiquitination at Lys 74, Lys 256, Lys 271, and Lys 404
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CNOT10 Gene

Domains & Families for CNOT10 Gene

Protein Domains for CNOT10 Gene

Graphical View of Domain Structure for InterPro Entry

Q9H9A5

UniProtKB/Swiss-Prot:

CNO10_HUMAN :
  • Belongs to the CNOT10 family.
Family:
  • Belongs to the CNOT10 family.
genes like me logo Genes that share domains with CNOT10: view

Function for CNOT10 Gene

Molecular function for CNOT10 Gene

UniProtKB/Swiss-Prot Function:
Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Is not required for association of CNOT7 to the CCR4-NOT complex.

Gene Ontology (GO) - Molecular Function for CNOT10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 23232451
genes like me logo Genes that share ontologies with CNOT10: view
genes like me logo Genes that share phenotypes with CNOT10: view

Animal Model Products

miRNA for CNOT10 Gene

miRTarBase miRNAs that target CNOT10

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CNOT10 Gene

Localization for CNOT10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CNOT10 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CNOT10 Gene COMPARTMENTS Subcellular localization image for CNOT10 gene
Compartment Confidence
cytosol 5
nucleus 5
cytoskeleton 2

Gene Ontology (GO) - Cellular Components for CNOT10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0016020 membrane IDA 19946888
GO:0030014 CCR4-NOT complex IDA 19558367
genes like me logo Genes that share ontologies with CNOT10: view

Pathways & Interactions for CNOT10 Gene

genes like me logo Genes that share pathways with CNOT10: view

Gene Ontology (GO) - Biological Process for CNOT10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening TAS --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006417 regulation of translation IEA --
GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest TAS --
genes like me logo Genes that share ontologies with CNOT10: view

No data available for SIGNOR curated interactions for CNOT10 Gene

Transcripts for CNOT10 Gene

Unigene Clusters for CNOT10 Gene

CCR4-NOT transcription complex, subunit 10:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CNOT10 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b ^ 17 ^
SP1: -
SP2: -
SP3: - -
SP4: - -
SP5: - - - -
SP6:
SP7:
SP8: - - -
SP9: - -
SP10:
SP11:
SP12:

ExUns: 18a · 18b ^ 19 ^ 20a · 20b ^ 21a · 21b · 21c · 21d
SP1: - - -
SP2: - - -
SP3: - - -
SP4: - - -
SP5: - - -
SP6: - - -
SP7: - - -
SP8:
SP9:
SP10: - -
SP11: -
SP12:

Relevant External Links for CNOT10 Gene

GeneLoc Exon Structure for
CNOT10
ECgene alternative splicing isoforms for
CNOT10

Expression for CNOT10 Gene

mRNA expression in normal human tissues for CNOT10 Gene

Protein differential expression in normal tissues from HIPED for CNOT10 Gene

This gene is overexpressed in Monocytes (9.3) and Breast (9.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CNOT10 Gene



Protein tissue co-expression partners for CNOT10 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CNOT10 Gene:

CNOT10

SOURCE GeneReport for Unigene cluster for CNOT10 Gene:

Hs.444851
genes like me logo Genes that share expression patterns with CNOT10: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CNOT10 Gene

Orthologs for CNOT10 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CNOT10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CNOT10 34 35
  • 99.92 (n)
dog
(Canis familiaris)
Mammalia CNOT10 34 35
  • 93.19 (n)
cow
(Bos Taurus)
Mammalia CNOT10 34 35
  • 92.58 (n)
mouse
(Mus musculus)
Mammalia Cnot10 34 16 35
  • 88.39 (n)
rat
(Rattus norvegicus)
Mammalia Cnot10 34
  • 88.35 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CNOT10 35
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CNOT10 35
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves CNOT10 34 35
  • 82.32 (n)
lizard
(Anolis carolinensis)
Reptilia CNOT10 35
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cnot10 34
  • 76.96 (n)
Str.11981 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.8121 34
zebrafish
(Danio rerio)
Actinopterygii cnot10 34 35
  • 71.19 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009674 34
  • 43.25 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG18616 34 35
  • 40.29 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G35430 34
  • 44.41 (n)
rice
(Oryza sativa)
Liliopsida Os09g0123100 34
  • 43.73 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2239 35
  • 32 (a)
OneToOne
Species where no ortholog for CNOT10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CNOT10 Gene

ENSEMBL:
Gene Tree for CNOT10 (if available)
TreeFam:
Gene Tree for CNOT10 (if available)

Paralogs for CNOT10 Gene

No data available for Paralogs for CNOT10 Gene

Variants for CNOT10 Gene

Sequence variations from dbSNP and Humsavar for CNOT10 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs10558501 -- 32,760,132(+) AGATC(-/TCT)GCACC intron-variant
rs10576116 -- 32,701,285(+) TTACC(-/TA)TATAT intron-variant
rs10589864 -- 32,717,515(+) AACTC(-/ACTT)AAACA intron-variant
rs10590243 -- 32,729,785(+) ttttt(-/TT)gagac intron-variant
rs10601313 -- 32,709,699(+) ACCAG(-/TG)GTAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CNOT10 Gene

Variant ID Type Subtype PubMed ID
esv1454338 CNV deletion 17803354
esv2515147 CNV deletion 19546169
esv2657972 CNV deletion 23128226
esv2725112 CNV deletion 23290073
esv2837125 CNV deletion 24192839
esv3561707 CNV deletion 23714750
esv3595781 CNV loss 21293372
esv999127 CNV deletion 20482838
nsv1003285 CNV gain 25217958
nsv1004530 CNV gain 25217958
nsv1072302 CNV deletion 25765185
nsv1072679 CNV deletion 25765185
nsv1121728 CNV deletion 24896259
nsv1122061 CNV deletion 24896259
nsv1149497 CNV deletion 26484159
nsv237812 CNV deletion 16902084
nsv508908 CNV insertion 20534489
nsv513041 CNV loss 21212237
nsv822050 CNV loss 20364138
nsv998302 CNV gain 25217958

Variation tolerance for CNOT10 Gene

Residual Variation Intolerance Score: 5.29% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.42; 54.47% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CNOT10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CNOT10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CNOT10 Gene

Disorders for CNOT10 Gene

Relevant External Links for CNOT10

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CNOT10

No disorders were found for CNOT10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CNOT10 Gene

Publications for CNOT10 Gene

  1. C2ORF29/CNOT11 and CNOT10 form a new module of the CCR4-NOT complex. (PMID: 23232451) Mauxion F. … Seraphin B. (RNA Biol. 2013) 3 4 64
  2. NOT10 and C2orf29/NOT11 form a conserved module of the CCR4-NOT complex that docks onto the NOT1 N-terminal domain. (PMID: 23303381) Bawankar P. … Izaurralde E. (RNA Biol. 2013) 3 4 64
  3. Human Ccr4-Not complexes contain variable deadenylase subunits. (PMID: 19558367) Lau N.C. … Timmers H.T. (Biochem. J. 2009) 3 4 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes. (PMID: 25281560) Lambert J.P. … Gingras A.C. (J Proteomics 2015) 3 64

Products for CNOT10 Gene

Sources for CNOT10 Gene

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