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Aliases for CNOT10 Gene

Aliases for CNOT10 Gene

  • CCR4-NOT Transcription Complex, Subunit 10 2 3

External Ids for CNOT10 Gene

Previous GeneCards Identifiers for CNOT10 Gene

  • GC03P032698
  • GC03P032701

Summaries for CNOT10 Gene

GeneCards Summary for CNOT10 Gene

CNOT10 (CCR4-NOT Transcription Complex, Subunit 10) is a Protein Coding gene. Among its related pathways are Gene Expression and Deadenylation-dependent mRNA decay.

UniProtKB/Swiss-Prot for CNOT10 Gene

  • Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Is not required for association of CNOT7 to the CCR4-NOT complex.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CNOT10 Gene

Genomics for CNOT10 Gene

Regulatory Elements for CNOT10 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CNOT10 Gene

Start:
32,685,145 bp from pter
End:
32,773,875 bp from pter
Size:
88,731 bases
Orientation:
Plus strand

Genomic View for CNOT10 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CNOT10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CNOT10 Gene

Proteins for CNOT10 Gene

  • Protein details for CNOT10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H9A5-CNO10_HUMAN
    Recommended name:
    CCR4-NOT transcription complex subunit 10
    Protein Accession:
    Q9H9A5
    Secondary Accessions:
    • B7Z7L1
    • F8WAF2
    • Q9BU30
    • Q9H5J7
    • Q9H8X1
    • Q9H9W0
    • Q9HAH3
    • Q9UFJ2

    Protein attributes for CNOT10 Gene

    Size:
    744 amino acids
    Molecular mass:
    82310 Da
    Quaternary structure:
    • Component of the CCR4-NOT complex; distinct complexes seem to exist that differ in the participation of probably mutually exclusive catalytic subunits. CNOT10 and CNOT11 form a subcomplex docked to the CNOT1 scaffold.
    SequenceCaution:
    • Sequence=BAB13876.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for CNOT10 Gene

neXtProt entry for CNOT10 Gene

Proteomics data for CNOT10 Gene at MOPED

Post-translational modifications for CNOT10 Gene

  • Ubiquitination at Lys74, Lys256, Lys271, and Lys404
  • Modification sites at PhosphoSitePlus

Other Protein References for CNOT10 Gene

No data available for DME Specific Peptides for CNOT10 Gene

Domains for CNOT10 Gene

Gene Families for CNOT10 Gene

HGNC:
  • TTC :Tetratricopeptide (TTC) repeat domain containing

Protein Domains for CNOT10 Gene

Graphical View of Domain Structure for InterPro Entry

Q9H9A5

UniProtKB/Swiss-Prot:

CNO10_HUMAN :
  • Q9H9A5
Family:
  • Belongs to the CNOT10 family.
genes like me logo Genes that share domains with CNOT10: view

Function for CNOT10 Gene

Molecular function for CNOT10 Gene

UniProtKB/Swiss-Prot Function: Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Is not required for association of CNOT7 to the CCR4-NOT complex.

Gene Ontology (GO) - Molecular Function for CNOT10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 23232451
genes like me logo Genes that share ontologies with CNOT10: view

Phenotypes for CNOT10 Gene

GenomeRNAi human phenotypes for CNOT10:
genes like me logo Genes that share phenotypes with CNOT10: view

Animal Model Products

CRISPR Products

miRNA for CNOT10 Gene

miRTarBase miRNAs that target CNOT10

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for CNOT10 Gene

Localization for CNOT10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CNOT10 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CNOT10 Gene COMPARTMENTS Subcellular localization image for CNOT10 gene
Compartment Confidence
cytosol 4
nucleus 4

Gene Ontology (GO) - Cellular Components for CNOT10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005829 cytosol TAS --
GO:0016020 membrane IDA 19946888
GO:0030014 CCR4-NOT complex IDA 19558367
genes like me logo Genes that share ontologies with CNOT10: view

Pathways for CNOT10 Gene

genes like me logo Genes that share pathways with CNOT10: view

Pathways by source for CNOT10 Gene

1 KEGG pathway for CNOT10 Gene

Gene Ontology (GO) - Biological Process for CNOT10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay TAS --
GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening TAS --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006417 regulation of translation IEA --
genes like me logo Genes that share ontologies with CNOT10: view

Transcripts for CNOT10 Gene

Unigene Clusters for CNOT10 Gene

CCR4-NOT transcription complex, subunit 10:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CNOT10

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CNOT10 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b ^ 17 ^
SP1: -
SP2: -
SP3: - -
SP4: - -
SP5: - - - -
SP6:
SP7:
SP8: - - -
SP9: - -
SP10:
SP11:
SP12:

ExUns: 18a · 18b ^ 19 ^ 20a · 20b ^ 21a · 21b · 21c · 21d
SP1: - - -
SP2: - - -
SP3: - - -
SP4: - - -
SP5: - - -
SP6: - - -
SP7: - - -
SP8:
SP9:
SP10: - -
SP11: -
SP12:

Relevant External Links for CNOT10 Gene

GeneLoc Exon Structure for
CNOT10
ECgene alternative splicing isoforms for
CNOT10

Expression for CNOT10 Gene

mRNA expression in normal human tissues for CNOT10 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CNOT10 Gene

SOURCE GeneReport for Unigene cluster for CNOT10 Gene Hs.444851

genes like me logo Genes that share expressions with CNOT10: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CNOT10 Gene

Orthologs for CNOT10 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CNOT10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CNOT10 35
  • 99.92 (n)
  • 99.75 (a)
CNOT10 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CNOT10 35
  • 92.58 (n)
  • 97.42 (a)
CNOT10 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CNOT10 35
  • 93.19 (n)
  • 95.52 (a)
CNOT10 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cnot10 35
  • 88.39 (n)
  • 96.21 (a)
Cnot10 16
Cnot10 36
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CNOT10 36
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CNOT10 36
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cnot10 35
  • 88.35 (n)
  • 95.66 (a)
chicken
(Gallus gallus)
Aves CNOT10 35
  • 82.32 (n)
  • 92.27 (a)
CNOT10 36
  • 92 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CNOT10 36
  • 90 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.8121 35
tropical clawed frog
(Silurana tropicalis)
Amphibia cnot10 35
  • 76.96 (n)
  • 82.27 (a)
Str.11981 35
zebrafish
(Danio rerio)
Actinopterygii cnot10 35
  • 71.19 (n)
  • 77.67 (a)
cnot10 36
  • 76 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009674 35
  • 43.25 (n)
  • 32.1 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG18616 35
  • 40.29 (n)
  • 30.17 (a)
CG18616 36
  • 27 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G35430 35
  • 44.41 (n)
  • 32 (a)
rice
(Oryza sativa)
Liliopsida Os09g0123100 35
  • 43.73 (n)
  • 32.91 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2239 36
  • 32 (a)
OneToOne
Species with no ortholog for CNOT10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CNOT10 Gene

ENSEMBL:
Gene Tree for CNOT10 (if available)
TreeFam:
Gene Tree for CNOT10 (if available)

Paralogs for CNOT10 Gene

No data available for Paralogs for CNOT10 Gene

Variants for CNOT10 Gene

Sequence variations from dbSNP and Humsavar for CNOT10 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs2521 -- 32,753,813(+) GTCGG(A/G)TGGTA intron-variant
rs2396631 -- 32,773,739(+) CTGAC(A/T)TTTGG utr-variant-3-prime
rs3763569 -- 32,773,207(-) CCAGG(C/T)AGAGA intron-variant
rs3763570 -- 32,773,056(-) AACCC(C/T)GTCTC intron-variant
rs3763571 -- 32,772,972(-) aggag(A/G)gctgc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CNOT10 Gene

Variant ID Type Subtype PubMed ID
nsv508908 CNV Insertion 20534489
nsv822050 CNV Loss 20364138
nsv237812 CNV Loss 16902084
esv2515147 CNV Deletion 19546169
esv2725112 CNV Deletion 23290073
nsv513041 CNV Loss 21212237
esv2657972 CNV Deletion 23128226
esv999127 CNV Deletion 20482838
esv1454338 CNV Deletion 17803354

Relevant External Links for CNOT10 Gene

HapMap Linkage Disequilibrium report
CNOT10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CNOT10 Gene

Disorders for CNOT10 Gene

No disorders were found for CNOT10 Gene.

No data available for UniProtKB/Swiss-Prot for CNOT10 Gene

Publications for CNOT10 Gene

  1. Human Ccr4-Not complexes contain variable deadenylase subunits. (PMID: 19558367) Lau N.C. … Timmers H.T. (Biochem. J. 2009) 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. C2ORF29/CNOT11 and CNOT10 form a new module of the CCR4-NOT complex. (PMID: 23232451) Mauxion F. … Seraphin B. (RNA Biol. 2013) 3 4
  4. NOT10 and C2orf29/NOT11 form a conserved module of the CCR4-NOT complex that docks onto the NOT1 N-terminal domain. (PMID: 23303381) Bawankar P. … Izaurralde E. (RNA Biol. 2013) 3 4
  5. VCP phosphorylation-dependent interaction partners prevent apoptosis in Helicobacter pylori-infected gastric epithelial cells. (PMID: 23383273) Yu C.C. … Chow L.P. (PLoS ONE 2013) 3

Products for CNOT10 Gene

Sources for CNOT10 Gene

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