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Aliases for CNOT10 Gene

Aliases for CNOT10 Gene

  • CCR4-NOT Transcription Complex Subunit 10 2 3 5
  • CCR4-NOT Transcription Complex, Subunit 10 2

External Ids for CNOT10 Gene

Previous GeneCards Identifiers for CNOT10 Gene

  • GC03P032698
  • GC03P032701

Summaries for CNOT10 Gene

GeneCards Summary for CNOT10 Gene

CNOT10 (CCR4-NOT Transcription Complex Subunit 10) is a Protein Coding gene. Among its related pathways are Deadenylation-dependent mRNA decay and TP53 Regulates Transcription of Cell Cycle Genes.

UniProtKB/Swiss-Prot for CNOT10 Gene

  • Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Is not required for association of CNOT7 to the CCR4-NOT complex.

Additional gene information for CNOT10 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CNOT10 Gene

Genomics for CNOT10 Gene

Regulatory Elements for CNOT10 Gene

Enhancers for CNOT10 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03H033437 1.4 ENCODE dbSUPER 56.1 +754.8 754792 5.5 HDGF PKNOX1 FOXA2 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 CNOT10 PDCD6IP UBP1 FBXL2 GLB1 TMPPE CMTM6 PIR40256 GC03M033417
GH03H033113 1.1 ENCODE 45.1 +429.6 429562 3.1 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 FOS CNOT10 PDCD6IP UBP1 CRTAP TMPPE GLB1 ENSG00000271643 ENSG00000236732 ENSG00000271020 GC03P033114
GH03H032832 1.1 ENCODE dbSUPER 42.1 +148.2 148150 0.7 ZFP64 ZNF140 ZNF266 ZNF384 ZNF697 ZNF664 ZNF791 POLR2A GLI2 ZNF547 CNOT10 UBP1 PDCD6IP FBXL2 TMPPE GLB1 TRIM71 PIR32571
GH03H032501 1.3 ENCODE dbSUPER 32.8 -182.8 -182805 2.7 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A FEZF1 DMAP1 YY1 SP3 CNOT10 CMTM6 UBP1 DYNC1LI1 SUGT1P2 CNOT10-AS1 GC03P032466
GH03H032778 1.9 FANTOM5 Ensembl ENCODE dbSUPER 22.1 +95.7 95686 4.1 HDGF FOXA2 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZNF143 DEK CNOT10 TRIM71 SUGT1P2 CNOT10-AS1 UBP1 RPL23AP43
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CNOT10 on UCSC Golden Path with GeneCards custom track

Promoters for CNOT10 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000150559 355 1801 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 YY1 ZNF143 ZNF207 SP3

Genomic Locations for CNOT10 Gene

Genomic Locations for CNOT10 Gene
chr3:32,685,145-32,773,875
(GRCh38/hg38)
Size:
88,731 bases
Orientation:
Plus strand
chr3:32,726,637-32,815,367
(GRCh37/hg19)

Genomic View for CNOT10 Gene

Genes around CNOT10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CNOT10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CNOT10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CNOT10 Gene

Proteins for CNOT10 Gene

  • Protein details for CNOT10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H9A5-CNO10_HUMAN
    Recommended name:
    CCR4-NOT transcription complex subunit 10
    Protein Accession:
    Q9H9A5
    Secondary Accessions:
    • B7Z7L1
    • F8WAF2
    • Q9BU30
    • Q9H5J7
    • Q9H8X1
    • Q9H9W0
    • Q9HAH3
    • Q9UFJ2

    Protein attributes for CNOT10 Gene

    Size:
    744 amino acids
    Molecular mass:
    82310 Da
    Quaternary structure:
    • Component of the CCR4-NOT complex; distinct complexes seem to exist that differ in the participation of probably mutually exclusive catalytic subunits. CNOT10 and CNOT11 form a subcomplex docked to the CNOT1 scaffold.
    SequenceCaution:
    • Sequence=BAB13876.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for CNOT10 Gene

neXtProt entry for CNOT10 Gene

Post-translational modifications for CNOT10 Gene

  • Ubiquitination at Lys74, posLast=256256, Lys271, and Lys404
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CNOT10 Gene

Domains & Families for CNOT10 Gene

Gene Families for CNOT10 Gene

Protein Domains for CNOT10 Gene

Graphical View of Domain Structure for InterPro Entry

Q9H9A5

UniProtKB/Swiss-Prot:

CNO10_HUMAN :
  • Belongs to the CNOT10 family.
Family:
  • Belongs to the CNOT10 family.
genes like me logo Genes that share domains with CNOT10: view

Function for CNOT10 Gene

Molecular function for CNOT10 Gene

UniProtKB/Swiss-Prot Function:
Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Is not required for association of CNOT7 to the CCR4-NOT complex.

Phenotypes From GWAS Catalog for CNOT10 Gene

Gene Ontology (GO) - Molecular Function for CNOT10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 23232451
genes like me logo Genes that share ontologies with CNOT10: view
genes like me logo Genes that share phenotypes with CNOT10: view

miRNA for CNOT10 Gene

miRTarBase miRNAs that target CNOT10

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CNOT10 Gene

Localization for CNOT10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CNOT10 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CNOT10 gene
Compartment Confidence
nucleus 5
cytosol 5
cytoskeleton 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Centrosome (2)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CNOT10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0016020 membrane IDA 19946888
GO:0030014 CCR4-NOT complex IDA 19558367
genes like me logo Genes that share ontologies with CNOT10: view

Pathways & Interactions for CNOT10 Gene

genes like me logo Genes that share pathways with CNOT10: view

Gene Ontology (GO) - Biological Process for CNOT10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening TAS --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006417 regulation of translation IEA --
GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest TAS --
genes like me logo Genes that share ontologies with CNOT10: view

No data available for SIGNOR curated interactions for CNOT10 Gene

Drugs & Compounds for CNOT10 Gene

No Compound Related Data Available

Transcripts for CNOT10 Gene

Unigene Clusters for CNOT10 Gene

CCR4-NOT transcription complex, subunit 10:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CNOT10 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b ^ 17 ^
SP1: -
SP2: -
SP3: - -
SP4: - -
SP5: - - - -
SP6:
SP7:
SP8: - - -
SP9: - -
SP10:
SP11:
SP12:

ExUns: 18a · 18b ^ 19 ^ 20a · 20b ^ 21a · 21b · 21c · 21d
SP1: - - -
SP2: - - -
SP3: - - -
SP4: - - -
SP5: - - -
SP6: - - -
SP7: - - -
SP8:
SP9:
SP10: - -
SP11: -
SP12:

Relevant External Links for CNOT10 Gene

GeneLoc Exon Structure for
CNOT10
ECgene alternative splicing isoforms for
CNOT10

Expression for CNOT10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CNOT10 Gene

Protein differential expression in normal tissues from HIPED for CNOT10 Gene

This gene is overexpressed in Monocytes (9.3) and Breast (9.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CNOT10 Gene



Protein tissue co-expression partners for CNOT10 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CNOT10 Gene:

CNOT10

SOURCE GeneReport for Unigene cluster for CNOT10 Gene:

Hs.444851

Evidence on tissue expression from TISSUES for CNOT10 Gene

  • Liver(4.2)
  • Skin(4.2)
  • Nervous system(2.4)
genes like me logo Genes that share expression patterns with CNOT10: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CNOT10 Gene

Orthologs for CNOT10 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CNOT10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CNOT10 33 34
  • 99.92 (n)
dog
(Canis familiaris)
Mammalia CNOT10 33 34
  • 93.19 (n)
cow
(Bos Taurus)
Mammalia CNOT10 33 34
  • 92.58 (n)
mouse
(Mus musculus)
Mammalia Cnot10 33 16 34
  • 88.39 (n)
rat
(Rattus norvegicus)
Mammalia Cnot10 33
  • 88.35 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CNOT10 34
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CNOT10 34
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves CNOT10 33 34
  • 82.32 (n)
lizard
(Anolis carolinensis)
Reptilia CNOT10 34
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cnot10 33
  • 76.96 (n)
Str.11981 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.8121 33
zebrafish
(Danio rerio)
Actinopterygii cnot10 33 34
  • 71.19 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009674 33
  • 43.25 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG18616 33 34
  • 40.29 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G35430 33
  • 44.41 (n)
rice
(Oryza sativa)
Liliopsida Os09g0123100 33
  • 43.73 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2239 34
  • 32 (a)
OneToOne
Species where no ortholog for CNOT10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CNOT10 Gene

ENSEMBL:
Gene Tree for CNOT10 (if available)
TreeFam:
Gene Tree for CNOT10 (if available)

Paralogs for CNOT10 Gene

No data available for Paralogs for CNOT10 Gene

Variants for CNOT10 Gene

Sequence variations from dbSNP and Humsavar for CNOT10 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000033811 -- 32,771,664(+) AATTG(A/C)TAGAT intron-variant
rs1000045875 -- 32,730,036(+) GTGCT(G/T)GGATT intron-variant
rs1000079858 -- 32,692,074(+) GCCAA(C/T)TTCCC intron-variant
rs1000112149 -- 32,764,042(+) AGAGA(A/G)TCACT intron-variant
rs1000154190 -- 32,724,615(+) CACCA(C/T)GTTAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CNOT10 Gene

Variant ID Type Subtype PubMed ID
nsv998302 CNV gain 25217958
nsv822050 CNV loss 20364138
nsv513041 CNV loss 21212237
nsv508908 CNV insertion 20534489
nsv237812 CNV deletion 16902084
nsv1149497 CNV deletion 26484159
nsv1122061 CNV deletion 24896259
nsv1121728 CNV deletion 24896259
nsv1072679 CNV deletion 25765185
nsv1072302 CNV deletion 25765185
nsv1004530 CNV gain 25217958
nsv1003285 CNV gain 25217958
esv999127 CNV deletion 20482838
esv3595781 CNV loss 21293372
esv3561707 CNV deletion 23714750
esv2837125 CNV deletion 24192839
esv2725112 CNV deletion 23290073
esv2657972 CNV deletion 23128226
esv2515147 CNV deletion 19546169
esv1454338 CNV deletion 17803354

Variation tolerance for CNOT10 Gene

Residual Variation Intolerance Score: 5.29% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.42; 54.47% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CNOT10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CNOT10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CNOT10 Gene

Disorders for CNOT10 Gene

Relevant External Links for CNOT10

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CNOT10

No disorders were found for CNOT10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CNOT10 Gene

Publications for CNOT10 Gene

  1. C2ORF29/CNOT11 and CNOT10 form a new module of the CCR4-NOT complex. (PMID: 23232451) Mauxion F … Séraphin B (RNA biology 2013) 3 4 60
  2. NOT10 and C2orf29/NOT11 form a conserved module of the CCR4-NOT complex that docks onto the NOT1 N-terminal domain. (PMID: 23303381) Bawankar P … Izaurralde E (RNA biology 2013) 3 4 60
  3. Human Ccr4-Not complexes contain variable deadenylase subunits. (PMID: 19558367) Lau NC … Timmers HT (The Biochemical journal 2009) 3 4 60
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60

Products for CNOT10 Gene

Sources for CNOT10 Gene

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