Aliases for CNOT1 Gene
External Ids for CNOT1 Gene
Previous HGNC Symbols for CNOT1 Gene
Previous GeneCards Identifiers for CNOT1 Gene
GeneCards Summary for CNOT1 Gene
CNOT1 (CCR4-NOT Transcription Complex Subunit 1) is a Protein Coding gene. Diseases associated with CNOT1 include Iritis. Among its related pathways are TP53 Regulates Transcription of Cell Cycle Genes and Regulation of TP53 Activity. GO annotations related to this gene include poly(A) RNA binding and protein domain specific binding.
UniProtKB/Swiss-Prot for CNOT1 Gene
Scaffolding component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Its scaffolding function implies its interaction with the catalytic complex module and diverse RNA-binding proteins mediating the complex recruitment to selected mRNA 3UTRs. Involved in degradation of AU-rich element (ARE)-containing mRNAs probably via association with ZFP36. Mediates the recruitment of the CCR4-NOT complex to miRNA targets and to the RISC complex via association with TNRC6A, TNRC6B or TNRC6C. Acts as a transcriptional repressor. Represses the ligand-dependent transcriptional activation by nuclear receptors. Involved in the maintenance of emryonic stem (ES) cell identity.