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CNOT1 Gene

protein-coding   GIFtS: 56
GCID: GC16M058553

CCR4-NOT Transcription Complex, Subunit 1


(Previous symbol: NOT1)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
CCR4-NOT Transcription Complex, Subunit 11 2     Adrenal Gland Protein AD-0052
NOT11 2 3 5     CCR4-NOT Transcription Complex Subunit 12
Negative Regulator Of Transcription Subunit 1 Homolog2 3     NOT1 (Negative Regulator Of Transcription 1, Yeast) Homolog2
CDC392 3     KIAA10073
NOT1H2 3     hNOT13
CCR4-Associated Factor 12 3     

External Ids:    HGNC: 78771   Entrez Gene: 230192   Ensembl: ENSG000001251077   OMIM: 6049175   UniProtKB: A5YKK63   

Export aliases for CNOT1 gene to outside databases

Previous GC identifers: GC00U990233 GC16M057112 GC16M044421


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CNOT1 Gene:
CNOT1 (CCR4-NOT transcription complex, subunit 1) is a protein-coding gene. GO annotations related to this gene include retinoic acid receptor binding and poly(A)-specific ribonuclease activity.

UniProtKB/Swiss-Prot: CNOT1_HUMAN, A5YKK6
Function: Scaffolding component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and
is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational
repression during translational initiation and general transcription regulation. Additional complex functions may
be a consequence of its influence on mRNA expression. Its scaffolding function implies its interaction with the
catalytic complex module and diverse RNA-binding proteins mediating the complex recruitment to selected mRNA
3'UTRs. Involved in degradation of AU-rich element (ARE)-containing mRNAs probably via association with ZFP36.
Mediates the recruitment of the CCR4-NOT complex to miRNA targets and to the RISC complex via association with
TNRC6A, TNRC6B or TNRC6C. Acts as a transcriptional repressor. Represses the ligand-dependent transcriptional
activation by nuclear receptors. Involved in the maintenance of emryonic stem (ES) cell identity

Gene Wiki entry for CNOT1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NC_018927.2  NT_010498.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the CNOT1 gene promoter:
         HNF-4alpha1   YY1   PPAR-gamma1   CBF-B   CBF-A   PPAR-gamma2   CBF(2)   ATF   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCNOT1 promoter sequence
   Search Chromatin IP Primers for CNOT1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CNOT1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q21   Ensembl cytogenetic band:  16q21   HGNC cytogenetic band: 16q21

CNOT1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CNOT1 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M058553:  view genomic region     (about GC identifiers)

Start:
58,553,855 bp from pter      End:
58,663,790 bp from pter
Size:
109,936 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CNOT1_HUMAN, A5YKK6 (See protein sequence)
Recommended Name: CCR4-NOT transcription complex subunit 1  
Size: 2376 amino acids; 266939 Da
Subunit: Component of the CCR4-NOT complex; distinct complexes seem to exist that differ in the participation of
probably mutually exclusive catalytic subunits. In the complex, interacts directly with CNOT6, CNOT6L, CNOT7 or
CNOT8. Interacts in a ligand-dependent fashion with ESR1 and RXRA. Interacts with NANOS2, TOB1 and ZFP36.
Interacts with TNRC6A, TNRC6B or TNRC6C; the interactions are direct
Developmental stage: Expressed in embryonic stem (ES) cells
Sequence caution: Sequence=AAF14861.1; Type=Frameshift; Positions=1969, 2273; Sequence=CAH18093.1; Type=Erroneous
initiation; Note=Translation N-terminally extended;
4 PDB 3D structures from and Proteopedia for CNOT1:
4C0D (3D)        4GMJ (3D)        4GML (3D)        4J8S (3D)    
Secondary accessions: Q68DX7 Q7Z3K2 Q8IWB8 Q8TB53 Q9BVZ6 Q9UFR8 Q9UI27 Q9Y2L0
Alternative splicing: 4 isoforms:  A5YKK6-1   A5YKK6-2   A5YKK6-3   A5YKK6-4   

Explore the universe of human proteins at neXtProt for CNOT1: NX_A5YKK6

Explore proteomics data for CNOT1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys1163, Lys2086
  • Modification sites at PhosphoSitePlus

  • See CNOT1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001252541.1  NP_057368.3  NP_996882.1  

    ENSEMBL proteins: 
     ENSP00000320949   ENSP00000455635   ENSP00000456649   ENSP00000454611   ENSP00000457173  
     ENSP00000413113   ENSP00000454763   ENSP00000458057   ENSP00000456131   ENSP00000454377  
     ENSP00000457460   ENSP00000456975   ENSP00000455289   ENSP00000457869   ENSP00000245138  
    Reactome Protein details: A5YKK6

    CNOT1 Human Recombinant Protein Products:

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    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
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    Novus Biologicals CNOT1 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CNOT1

     
    Search eBioscience for Proteins for CNOT1 

     
    antibodies-online proteins for CNOT1 (2 products) 

     
    Search antibodies-online for peptides for CNOT1

    CNOT1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Search for Antibodies for CNOT1 at Abcam
    Cloud-Clone Corp. Antibodies for CNOT1
    Search ThermoFisher Antibodies for CNOT1
    antibodies-online antibodies for CNOT1 (4 products) 

    CNOT1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for CNOT1
    Cloud-Clone Corp. CLIAs for CNOT1
    Search eBioscience for ELISAs for CNOT1 
    antibodies-online kits for CNOT1 (2 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR007196 CCR4-Not_Not1_C
     IPR024557 CCR4-Not_Not1su_DUF3819

    Graphical View of Domain Structure for InterPro Entry A5YKK6

    ProtoNet protein and cluster: A5YKK6

    UniProtKB/Swiss-Prot: CNOT1_HUMAN, A5YKK6
    Domain: Contains Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs, a motif known to be important for the association with
    nuclear receptors
    Similarity: Belongs to the CNOT1 family


    Find genes that share domains with CNOT1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CNOT1_HUMAN, A5YKK6
    Function: Scaffolding component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and
    is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational
    repression during translational initiation and general transcription regulation. Additional complex functions may
    be a consequence of its influence on mRNA expression. Its scaffolding function implies its interaction with the
    catalytic complex module and diverse RNA-binding proteins mediating the complex recruitment to selected mRNA
    3'UTRs. Involved in degradation of AU-rich element (ARE)-containing mRNAs probably via association with ZFP36.
    Mediates the recruitment of the CCR4-NOT complex to miRNA targets and to the RISC complex via association with
    TNRC6A, TNRC6B or TNRC6C. Acts as a transcriptional repressor. Represses the ligand-dependent transcriptional
    activation by nuclear receptors. Involved in the maintenance of emryonic stem (ES) cell identity

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004535contributes to poly(A)-specific ribonuclease activity IDA--
    GO:0005488binding ----
    GO:0005515protein binding IPI10637334
    GO:0030331estrogen receptor binding IDA16778766
    GO:0042974retinoic acid receptor binding IDA16778766
         
    Find genes that share ontologies with CNOT1           About GenesLikeMe


    Phenotypes:
         5 GenomeRNAi human phenotypes for CNOT1:
     Decreased POU5F1-GFP protein e  Decreased Wnt reporter activit  Increased gamma-H2AX phosphory  Synthetic lethal with Ras 
     Wnt reporter downregulated 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for CNOT1

    miRNA
    Products:
        
    miRTarBase miRNAs that target CNOT1:
    hsa-mir-193b-3p (MIRT041221), hsa-mir-423-3p (MIRT042519), hsa-mir-128-3p (MIRT045861), hsa-mir-421 (MIRT039422), hsa-mir-93-3p (MIRT038795), hsa-let-7b-5p (MIRT052277), hsa-mir-454-3p (MIRT039246), hsa-mir-766-3p (MIRT039055), hsa-mir-92a-3p (MIRT049821), hsa-mir-221-3p (MIRT046901), hsa-mir-744-5p (MIRT037620), hsa-mir-23a-3p (MIRT050410), hsa-mir-615-3p (MIRT039634), hsa-mir-130b-3p (MIRT044167)

    Block miRNA regulation of human, mouse, rat CNOT1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CNOT1 (see all 35):
    hsa-miR-26a-2* hsa-miR-300 hsa-miR-513a-5p hsa-miR-139-5p hsa-miR-486-3p hsa-miR-500a hsa-miR-29b-1* hsa-miR-133a
    SwitchGear 3'UTR luciferase reporter plasmidCNOT1 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for CNOT1
    Predesigned siRNA for gene silencing in human, mouse, rat CNOT1

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for CNOT1

    Clone
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    OriGene clones in human, mouse for CNOT1 (see all 11)
    OriGene ORF clones in mouse, rat for CNOT1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CNOT1 (NM_206999)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CNOT1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CNOT1
    Addgene plasmids for CNOT1 

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for CNOT1 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CNOT1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CNOT1_HUMAN, A5YKK6: Cytoplasm, P-body. Nucleus (Probable). Note=NANOS2 promotes its localization to P-body (By
    similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    peroxisome5
    cytosol4
    nucleus4
    endoplasmic reticulum1
    mitochondrion1
    plasma membrane1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000932cytoplasmic mRNA processing body ISS--
    GO:0005615extracellular space IDA--
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005778peroxisomal membrane IDA--

    Find genes that share ontologies with CNOT1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CNOT1 About    
    See pathways by source

    SuperPathContained pathways About
    1Deadenylation-dependent mRNA decay
    Deadenylation-dependent mRNA decay0.48
    Deadenylation of mRNA0.48
    RNA degradation0.48
    2Gene Expression
    Gene Expression0.40


    Find genes that share SuperPaths with CNOT1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for CNOT1
        Deadenylation of mRNA


    1 Kegg Pathway  (Kegg details for CNOT1):
        RNA degradation

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CNOT1
    Interactions:

        Search GeneGlobe Interaction Network for CNOT1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CNOT1 (A5YKK61, 3 ENSP000003209494) via UniProtKB, MINT, STRING, and/or I2D (see all 196)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CNOT2Q9NZN81, 3, ENSP000002291954EBI-1222758,EBI-743033 I2D: score=4 STRING: ENSP00000229195
    CNOT6LQ96LI51, 3, ENSP000002649034EBI-1222758,EBI-1046635 I2D: score=2 STRING: ENSP00000264903
    TOB1P506161, 3, ENSP000002689574EBI-1222758,EBI-723281 I2D: score=1 STRING: ENSP00000268957
    ENSG00000231502Q9Y3333, ENSP000004033454I2D: score=4 STRING: ENSP00000403345
    ENSG00000236826Q9Y3333, ENSP000004146344I2D: score=4 STRING: ENSP00000414634
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 17):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IDA16778766
    GO:0000288nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay TAS--
    GO:0000289nuclear-transcribed mRNA poly(A) tail shortening TAS--
    GO:0006351transcription, DNA-templated IEA--
    GO:0006417regulation of translation IEA--

    Find genes that share ontologies with CNOT1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CNOT1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CNOT1 gene (3 alternative transcripts): 
    NM_001265612.1  NM_016284.4  NM_206999.2  

    Unigene Cluster for CNOT1:

    CCR4-NOT transcription complex, subunit 1
    Hs.460923  [show with all ESTs]
    Unigene Representative Sequence: NR_049763
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 23):
    ENST00000317147(uc010vik.2 uc002env.3 uc002enw.3 uc002enu.4 uc002enz.1)
    ENST00000563130(uc002ent.3) ENST00000569240 ENST00000567188 ENST00000569924
    ENST00000570139 ENST00000568917 ENST00000563283 ENST00000566240 ENST00000441024(uc002enx.3)
    ENST00000567133 ENST00000567285 ENST00000569732 ENST00000562046 ENST00000569882
    ENST00000565605 ENST00000564557 ENST00000569916
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate CNOT1 (see all 35):
    hsa-miR-26a-2* hsa-miR-300 hsa-miR-513a-5p hsa-miR-139-5p hsa-miR-486-3p hsa-miR-500a hsa-miR-29b-1* hsa-miR-133a
    SwitchGear 3'UTR luciferase reporter plasmidCNOT1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CNOT1
    Clone
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    OriGene ORF clones in mouse, rat for CNOT1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CNOT1 (NM_206999)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CNOT1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CNOT1
    Addgene plasmids for CNOT1 
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for CNOT1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CNOT1
      QuantiTect SYBR Green Assays in human, mouse, rat CNOT1
      QuantiFast Probe-based Assays in human, mouse, rat CNOT1

    Additional mRNA sequence: 

    AB023224.2 AF110778.1 AK056927.1 AK075125.1 AK300281.1 AK301092.1 AK302495.1 AL117492.1 
    AL832769.1 AL833549.1 BC000779.2 BC011861.2 BC024317.1 BC027969.2 BC040523.1 BX537840.1 
    BX647815.1 CR749237.1 EF553522.1 NR_049763.1 

    Selected DOTS entries (see all 25):

    DT.119935  DT.100878056  DT.100878052  DT.95315571  DT.100878055  DT.91776456  DT.95337584  DT.95337585 
    DT.100802806  DT.92415399  DT.120655354  DT.100721201  DT.100849743  DT.100878051  DT.100878053  DT.120655393 
    DT.120655429  DT.91776454  DT.91996913  DT.120655339  DT.120655381  DT.40107045  DT.40254029  DT.75109778 

    Selected AceView cDNA sequences (see all 558):

    AA806166 CD370327 CB243577 BM451104 BM453794 AK056927 BM668196 BQ434013 
    N77602 BG778126 AL117492 BU657793 AA922463 CA416938 BU170502 BM818065 
    BC024317 BQ636518 AL045214 CB158833 AU125118 CA428402 BX647815 BU175362 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CNOT1 (see all 20)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^
    SP1:                          -     -     -     -     -     -                 -                                                                                 
    SP2:                          -     -     -     -     -     -                 -                                                                                 
    SP3:                                                                                                                                                            
    SP4:                          -     -     -     -     -     -                 -                                                                                 
    SP5:                          -     -     -     -     -     -                 -                       -     -     -     -     -     -     -     -     -     -   

    ExUns: 17a · 17b · 17c ^ 18a · 18b ^ 19 ^ 20 ^ 21 ^ 22a · 22b ^ 23a · 23b ^ 24 ^ 25 ^ 26 ^ 27a · 27b ^ 28 ^ 29a · 29b ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35a ·
    SP1:                                                        -                                                                                                   
    SP2:                                                                                                                                                            
    SP3:                                                        -                                                                                                   
    SP4:                                                                                                                                                            
    SP5:  -     -                                                                                                           -     -     -     -     -     -     -   

    ExUns: 35b · 35c ^ 36 ^ 37 ^ 38 ^ 39 ^ 40a · 40b ^ 41 ^ 42a · 42b ^ 43 ^ 44 ^ 45a · 45b · 45c ^ 46a · 46b ^ 47a · 47b ^ 48a · 48b ^ 49 ^ 50 ^ 51 ^ 52 ^
    SP1:        -     -                       -                                                     -                 -                       -                     
    SP2:        -     -                       -                                                     -                 -                       -                 -   
    SP3:        -     -                       -                                                     -                 -                       -                 -   
    SP4:                                                                                                                                                            
    SP5:  -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -           -                       -                 -   

    ExUns: 53 ^ 54 ^ 55 ^ 56 ^ 57a · 57b · 57c ·
    SP1:                                          
    SP2:                                          
    SP3:                                          
    SP4:                                          
    SP5:                                          


    ECgene alternative splicing isoforms for CNOT1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    CNOT1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAAGAGAAAA
    CNOT1 Expression
    About this image


    CNOT1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 11) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Membranous Facial Bones
     
     Thymus (Hematopoietic System)
             Thymus
     
     Kidney (Urinary System)
             Metanephros
    CNOT1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CNOT1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.460923

    UniProtKB/Swiss-Prot: CNOT1_HUMAN, A5YKK6
    Tissue specificity: Strongly expressed in brain, heart, thymus, spleen, kidney, liver, placenta and lung. Weakly
    expressed in skeletal muscle and colon

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CNOT1 gene from Selected species (see all 25)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cnot11 , 5 CCR4-NOT transcription complex, subunit 11, 5 92.35(n)1
    99.37(a)1
      8 (47.18 cM)5
    2345941  NM_178078.21  NP_835179.11 
     957194515 
    chicken
    (Gallus gallus)
    Aves CNOT11 CCR4-NOT transcription complex subunit 1-like 86.15(n)
    97.73(a)
      100858397  NM_001277133.1  NP_001264062.1 
    lizard
    (Anolis carolinensis)
    Reptilia CNOT16
    CCR4-NOT transcription complex, subunit 1
    95(a)
    1 ↔ 1
    GL344149.1(19203-66337)
    African clawed frog
    (Xenopus laevis)
    Amphibia CD327656.12   -- 82.27(n)    CD327656.1 
    zebrafish
    (Danio rerio)
    Actinopterygii 570947572   -- 83.49(n)    57094757 
    fruit fly
    (Drosophila melanogaster)
    Insecta Not11 Not1 53.53(n)
    51.12(a)
      5740252  NM_165678.4  NP_724798.3 
    worm
    (Caenorhabditis elegans)
    Secernentea let-7111 let-711 51.32(n)
    44.68(a)
      175971  NM_066115.4  NP_498516.2 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CDC39(YCR093W)4 Component of the CCR4-NOT complex, which has multiple more   --   3(280117-286443) 850455  NP_010017.2 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G020801 AT1G02080 50.16(n)
    39.24(a)
      839244  NM_100088.5  NP_171710.4 
    rice
    (Oryza sativa)
    Liliopsida Os.40892 Oryza sativa (japonica cultivar-group) putative transcription more 72.61(n)    NM_197706.1 


    ENSEMBL Gene Tree for CNOT1 (if available)
    TreeFam Gene Tree for CNOT1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CNOT1 (see all 2449)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs370361,2
    C,F,A,H--44421346(-) CGAGTA/GCCAGT 3 -- ds500122Minor allele frequency- G:0.25MN NS EA NA WA 2532
    rs1932947411,2
    --58555378(+) AATAGC/GACAGG 3 -- int10--------
    rs1850150481,2
    --58555419(+) AGCCGC/TAGAAG 3 -- int10--------
    rs1488040431,2
    --58555426(+) GAAGAC/GTAAGT 3 -- int10--------
    rs1424536121,2
    C--58555455(+) TAATGG/TTATCT 3 -- int10--------
    rs620400731,2
    C--58555507(+) AGCCAC/TATAAA 3 -- int13Minor allele frequency- T:0.09NA EA 242
    rs99391331,2
    C,F,H--58555553(+) AGTAGA/TAATTT 3 -- int131Minor allele frequency- T:0.47NS EA NA WA CSA 2921
    rs1406670311,2
    --58555621(+) GAGGCC/TGAGGC 3 -- int10--------
    rs1875299151,2
    --58555654(+) AGTTCA/GAGACC 3 -- int10--------
    rs1443749451,2
    --58555803(+) TGAGCC/TGAGAT 3 -- int10--------

    HapMap Linkage Disequilibrium report for CNOT1 (58553855 - 58663790 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for CNOT1 (see all 30):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2714553CNV Deletion23290073
    esv2714556CNV Deletion23290073
    esv2714555CNV Deletion23290073
    esv2546975CNV Deletion19546169
    esv2714554CNV Deletion23290073
    esv2032869CNV Deletion18987734
    esv2614548CNV Deletion19546169
    esv4241CNV Deletion18987735
    dgv497e199CNV Deletion23128226
    nsv821034CNV Deletion20802225

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 604917    OMIM disorders: --


    Find genes that share disorders with CNOT1           About GenesLikeMe

    Genetic Association Database (GAD): CNOT1

    Export disorders for CNOT1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CNOT1 gene, integrated from 10 sources (see all 55):
    (articles sorted by number of sources associating them with CNOT1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Structural basis for the recruitment of the human CCR4-NOT deadenylase complex by tristetraprolin. (PubMed id 23644599)1, 2 Fabian M.R....Sonenberg N. (amp 2013)
    2. Cnot1, Cnot2, and Cnot3 maintain mouse and human ESC identity and inhibit extraembryonic differentiation. (PubMed id 22367759)1, 2 Zheng X.... Hu G. (Stem Cells 2012)
    3. The structural basis for the interaction between the CAF1 nuclease and the NOT1 scaffold of the human CCR4-NOT deadenylase complex. (PubMed id 22977175)1, 2 Petit A.P.... Weichenrieder O. (Nucleic Acids Res. 2012)
    4. The role of the CNOT1 subunit of the CCR4-NOT complex in mRNA deadenylation and cell viability. (PubMed id 21976065)1, 2 Ito K.... Yamamoto T. (Protein Cell 2011)
    5. Several common variants modulate heart rate, PR interval and QRS duration. (PubMed id 20062063)1, 4 Holm H....Stefansson K. (Nat. Genet. 2010)
    6. Common variants at ten loci influence QT interval duration in the QTGEN Study. (PubMed id 19305408)1, 4 Newton-Cheh C.... Stricker B.H. (Nat. Genet. 2009)
    7. Common variants at ten loci modulate the QT interval duration in the QTSCD Study. (PubMed id 19305409)1, 4 Pfeufer A.... Chakravarti A. (Nat. Genet. 2009)
    8. Human Ccr4-Not complexes contain variable deadenylase subunits. (PubMed id 19558367)1, 2 Lau N.C.... Timmers H.T. (Biochem. J. 2009)
    9. Interaction of antiproliferative protein Tob with the CCR4-NOT deadenylase complex. (PubMed id 18377426)1, 2 Miyasaka T.... Yamamoto T. (Cancer Sci. 2008)
    10. Human Ccr4-Not complex is a ligand-dependent repressor of nuclear receptor-mediated transcription. (PubMed id 16778766)1, 2 Winkler G.S.... Timmers H.T. (EMBO J. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 23019 HGNC: 7877 AceView: KIAA1007 Ensembl:ENSG00000125107 euGenes: HUgn23019
    ECgene: CNOT1 Kegg: 23019 H-InvDB: CNOT1

    (According to HUGE)
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    HUGE: KIAA1007

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CNOT1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CNOT1 gene:
    Search GeneIP for patents involving CNOT1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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