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Aliases for CNOT1 Gene

Aliases for CNOT1 Gene

  • CCR4-NOT Transcription Complex, Subunit 1 2 3
  • NOT1 3 4 6
  • Negative Regulator Of Transcription Subunit 1 Homolog 3 4
  • CCR4-Associated Factor 1 3 4
  • CDC39 3 4
  • NOT1H 3 4
  • NOT1 (Negative Regulator Of Transcription 1, Yeast) Homolog 3
  • CCR4-NOT Transcription Complex Subunit 1 3
  • Adrenal Gland Protein AD-005 3
  • KIAA1007 4
  • AD-005 3
  • HNOT1 4

External Ids for CNOT1 Gene

Previous HGNC Symbols for CNOT1 Gene

  • NOT1

Previous GeneCards Identifiers for CNOT1 Gene

  • GC00U990233
  • GC16M057112
  • GC16M058553
  • GC16M044421

Summaries for CNOT1 Gene

GeneCards Summary for CNOT1 Gene

CNOT1 (CCR4-NOT Transcription Complex, Subunit 1) is a Protein Coding gene. Among its related pathways are Gene Expression and Deadenylation-dependent mRNA decay. GO annotations related to this gene include retinoic acid receptor binding and poly(A)-specific ribonuclease activity.

UniProtKB/Swiss-Prot for CNOT1 Gene

  • Scaffolding component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Its scaffolding function implies its interaction with the catalytic complex module and diverse RNA-binding proteins mediating the complex recruitment to selected mRNA 3UTRs. Involved in degradation of AU-rich element (ARE)-containing mRNAs probably via association with ZFP36. Mediates the recruitment of the CCR4-NOT complex to miRNA targets and to the RISC complex via association with TNRC6A, TNRC6B or TNRC6C. Acts as a transcriptional repressor. Represses the ligand-dependent transcriptional activation by nuclear receptors. Involved in the maintenance of emryonic stem (ES) cell identity.

Gene Wiki entry for CNOT1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CNOT1 Gene

Genomics for CNOT1 Gene

Regulatory Elements for CNOT1 Gene

Genomic Location for CNOT1 Gene

Start:
58,519,946 bp from pter
End:
58,629,886 bp from pter
Size:
109,941 bases
Orientation:
Minus strand

Genomic View for CNOT1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CNOT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CNOT1 Gene

Proteins for CNOT1 Gene

  • Protein details for CNOT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A5YKK6-CNOT1_HUMAN
    Recommended name:
    CCR4-NOT transcription complex subunit 1
    Protein Accession:
    A5YKK6
    Secondary Accessions:
    • Q68DX7
    • Q7Z3K2
    • Q8IWB8
    • Q8TB53
    • Q9BVZ6
    • Q9UFR8
    • Q9UI27
    • Q9Y2L0

    Protein attributes for CNOT1 Gene

    Size:
    2376 amino acids
    Molecular mass:
    266939 Da
    Quaternary structure:
    • Component of the CCR4-NOT complex; distinct complexes seem to exist that differ in the participation of probably mutually exclusive catalytic subunits. In the complex, interacts directly with CNOT6, CNOT6L, CNOT7 or CNOT8. Interacts in a ligand-dependent fashion with ESR1 and RXRA. Interacts with NANOS2, TOB1 and ZFP36. Interacts with TNRC6A, TNRC6B or TNRC6C; the interactions are direct.
    SequenceCaution:
    • Sequence=AAF14861.1; Type=Frameshift; Positions=1969, 2273; Evidence={ECO:0000305}; Sequence=CAH18093.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CNOT1 Gene

    Alternative splice isoforms for CNOT1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CNOT1 Gene

Proteomics data for CNOT1 Gene at MOPED

Post-translational modifications for CNOT1 Gene

  • Ubiquitination at Lys1163 and Lys2086
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CNOT1 Gene

Domains for CNOT1 Gene

Protein Domains for CNOT1 Gene

Graphical View of Domain Structure for InterPro Entry

A5YKK6

UniProtKB/Swiss-Prot:

CNOT1_HUMAN :
  • A5YKK6
Domain:
  • Contains Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs, a motif known to be important for the association with nuclear receptors.
Family:
  • Belongs to the CNOT1 family.
genes like me logo Genes that share domains with CNOT1: view

No data available for Gene Families for CNOT1 Gene

Function for CNOT1 Gene

Molecular function for CNOT1 Gene

UniProtKB/Swiss-Prot Function: Scaffolding component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Its scaffolding function implies its interaction with the catalytic complex module and diverse RNA-binding proteins mediating the complex recruitment to selected mRNA 3UTRs. Involved in degradation of AU-rich element (ARE)-containing mRNAs probably via association with ZFP36. Mediates the recruitment of the CCR4-NOT complex to miRNA targets and to the RISC complex via association with TNRC6A, TNRC6B or TNRC6C. Acts as a transcriptional repressor. Represses the ligand-dependent transcriptional activation by nuclear receptors. Involved in the maintenance of emryonic stem (ES) cell identity.

Gene Ontology (GO) - Molecular Function for CNOT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004535 contributes_to poly(A)-specific ribonuclease activity IDA 21976065
GO:0005488 binding --
GO:0005515 protein binding IPI 10637334
GO:0019904 protein domain specific binding IPI 24768540
GO:0030331 estrogen receptor binding IDA 16778766
genes like me logo Genes that share ontologies with CNOT1: view
genes like me logo Genes that share phenotypes with CNOT1: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for CNOT1 Gene

Localization for CNOT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CNOT1 Gene

Cytoplasm, P-body. Nucleus. Note=NANOS2 promotes its localization to P-body. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CNOT1 Gene COMPARTMENTS Subcellular localization image for CNOT1 gene
Compartment Confidence
peroxisome 5
cytosol 4
nucleus 4
endoplasmic reticulum 1
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CNOT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000932 cytoplasmic mRNA processing body ISS --
GO:0005615 extracellular space IDA 22664934
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005778 peroxisomal membrane IDA 21525035
genes like me logo Genes that share ontologies with CNOT1: view

Pathways for CNOT1 Gene

genes like me logo Genes that share pathways with CNOT1: view

Pathways by source for CNOT1 Gene

1 KEGG pathway for CNOT1 Gene

Gene Ontology (GO) - Biological Process for CNOT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 16778766
GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay TAS --
GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening TAS --
GO:0006351 transcription, DNA-templated IEA --
GO:0006417 regulation of translation --
genes like me logo Genes that share ontologies with CNOT1: view

Transcripts for CNOT1 Gene

Unigene Clusters for CNOT1 Gene

CCR4-NOT transcription complex, subunit 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CNOT1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^
SP1: - - - - - - -
SP2: - - - - - - -
SP3:
SP4: - - - - - - -
SP5: - - - - - - - - - - - - - - - - -
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12: - - - - -
SP13: - - - -
SP14:
SP15:
SP16: - - - - -
SP17:
SP18: - - -
SP19: - - - - - -
SP20: - - -

ExUns: 17a · 17b · 17c ^ 18a · 18b ^ 19 ^ 20 ^ 21 ^ 22a · 22b ^ 23a · 23b ^ 24 ^ 25 ^ 26 ^ 27a · 27b ^ 28 ^ 29a · 29b ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35a ·
SP1: -
SP2:
SP3: -
SP4:
SP5: - - - - - - - - -
SP6:
SP7: - - - - - - - - - - - - -
SP8:
SP9: -
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:

ExUns: 35b · 35c ^ 36 ^ 37 ^ 38 ^ 39 ^ 40a · 40b ^ 41 ^ 42a · 42b ^ 43 ^ 44 ^ 45a · 45b · 45c ^ 46a · 46b ^ 47a · 47b ^ 48a · 48b ^ 49 ^ 50 ^ 51 ^ 52 ^
SP1: - - - - - -
SP2: - - - - - - -
SP3: - - - - - - -
SP4:
SP5: - - - - - - - - - - - - - - - - - - - -
SP6: - -
SP7: - - - - - - - -
SP8:
SP9:
SP10: -
SP11: - -
SP12:
SP13:
SP14: -
SP15: -
SP16:
SP17:
SP18:
SP19:
SP20:

ExUns: 53 ^ 54 ^ 55 ^ 56 ^ 57a · 57b · 57c ·
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:

Relevant External Links for CNOT1 Gene

GeneLoc Exon Structure for
CNOT1
ECgene alternative splicing isoforms for
CNOT1

Expression for CNOT1 Gene

mRNA expression in normal human tissues for CNOT1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CNOT1 Gene

SOURCE GeneReport for Unigene cluster for CNOT1 Gene Hs.460923

mRNA Expression by UniProt/SwissProt for CNOT1 Gene

A5YKK6-CNOT1_HUMAN
Tissue specificity: Strongly expressed in brain, heart, thymus, spleen, kidney, liver, placenta and lung. Weakly expressed in skeletal muscle and colon.
genes like me logo Genes that share expressions with CNOT1: view

No data available for mRNA differential expression in normal tissues for CNOT1 Gene

Orthologs for CNOT1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CNOT1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CNOT1 35
  • 99.87 (n)
  • 100 (a)
CNOT1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CNOT1 35
  • 95.26 (n)
  • 99.75 (a)
CNOT1 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CNOT1 35
  • 95.06 (n)
  • 99.71 (a)
CNOT1 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cnot1 35
  • 92.35 (n)
  • 99.37 (a)
Cnot1 16
Cnot1 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CNOT1 36
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 86 (a)
OneToMany
-- 36
  • 98 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Cnot1 35
  • 91.75 (n)
  • 99.33 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 100 (a)
OneToMany
CNOT1 35
  • 86.15 (n)
  • 97.73 (a)
CNOT1 36
  • 98 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia CNOT1 36
  • 95 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cnot1 35
  • 80.41 (n)
  • 93.99 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8458 35
zebrafish
(Danio rerio)
Actinopterygii cnot1 35
  • 77.76 (n)
  • 90.52 (a)
cnot1 36
  • 91 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009057 35
  • 55.05 (n)
  • 54.89 (a)
fruit fly
(Drosophila melanogaster)
Insecta Not1 35
  • 53.53 (n)
  • 51.12 (a)
Not1 36
  • 47 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea let-711 35
  • 51.32 (n)
  • 44.68 (a)
let-711 36
  • 32 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CDC39 36
  • 26 (a)
OneToOne
CDC39 38
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.11667 35
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G02080 35
  • 50.16 (n)
  • 39.24 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.4407 35
corn
(Zea mays)
Liliopsida Zm.7360 35
rice
(Oryza sativa)
Liliopsida Os.4089 35
Os10g0556801 35
  • 51.04 (n)
  • 42.12 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.5541 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3300 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6570 36
  • 60 (a)
OneToOne
Species with no ortholog for CNOT1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for CNOT1 Gene

ENSEMBL:
Gene Tree for CNOT1 (if available)
TreeFam:
Gene Tree for CNOT1 (if available)

Paralogs for CNOT1 Gene

No data available for Paralogs for CNOT1 Gene

Variants for CNOT1 Gene

Sequence variations from dbSNP and Humsavar for CNOT1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs27097 -- 58,630,161(+) GGAGA(G/T)GCTGA upstream-variant-2KB
rs28307 -- 58,543,234(+) TGTGC(A/C)CATGC intron-variant, utr-variant-3-prime
rs37037 -- 58,630,698(+) GTAGG(A/G)GACGC upstream-variant-2KB
rs37039 -- 58,544,187(-) CAGCA(A/G)TGTGT intron-variant
rs37040 -- 58,544,358(-) AGCCA(A/G)ATACT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CNOT1 Gene

Variant ID Type Subtype PubMed ID
dgv2876n71 CNV Loss 21882294
nsv827687 CNV Loss 20364138
dgv893e1 CNV Complex 17122850
nsv521338 CNV Loss 19592680
esv2546975 CNV Deletion 19546169
esv2714553 CNV Deletion 23290073
esv2032869 CNV Deletion 18987734
esv4241 CNV Deletion 18987735
esv2714554 CNV Deletion 23290073
nsv103597 CNV Loss 16902084
esv2714555 CNV Deletion 23290073
esv2466145 CNV Insertion 19546169
nsv511049 CNV Complex 20534489
nsv507819 CNV Insertion 20534489
esv33503 CNV Loss 17666407
nsv509623 CNV Insertion 20534489
nsv510686 CNV Loss 20534489
esv2614548 CNV Deletion 19546169
nsv9448 CNV Gain 18304495
nsv512440 CNV Loss 21212237
esv2714556 CNV Deletion 23290073
nsv819144 CNV Gain 19587683
dgv482n67 CNV Loss 20364138
dgv59e180 CNV Gain 20482838
nsv821034 CNV Deletion 20802225
dgv497e199 CNV Deletion 23128226
nsv103378 CNV Loss 16902084
esv24929 CNV Gain 19812545
nsv514806 CNV Loss 21397061
esv32972 CNV Gain+Loss 17666407

Relevant External Links for CNOT1 Gene

HapMap Linkage Disequilibrium report
CNOT1
Human Gene Mutation Database (HGMD)
CNOT1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CNOT1 Gene

Disorders for CNOT1 Gene

Relevant External Links for CNOT1

Genetic Association Database (GAD)
CNOT1
genes like me logo Genes that share disorders with CNOT1: view

No data available for UniProtKB/Swiss-Prot for CNOT1 Gene

Publications for CNOT1 Gene

  1. Purification and characterization of the 1.0 MDa CCR4-NOT complex identifies two novel components of the complex. (PMID: 11733989) Chen J. … Denis C.L. (J. Mol. Biol. 2001) 3 23
  2. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10231032) Nagase T. … Ohara O. (DNA Res. 1999) 3 4
  3. Isolation and characterization of human orthologs of yeast CCR4-NOT complex subunits. (PMID: 10637334) Albert T.K. … Timmers H.T.M. (Nucleic Acids Res. 2000) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 2 3
  5. Human Ccr4-Not complex is a ligand-dependent repressor of nuclear receptor-mediated transcription. (PMID: 16778766) Winkler G.S. … Timmers H.T. (EMBO J. 2006) 3 4

Products for CNOT1 Gene

Sources for CNOT1 Gene

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