CNOT1 Gene
protein-coding GIFtS: 54
GCID: GC16M058553
|
|
CCR4-NOT transcription complex, subunit 1
(Previous symbol: NOT1)
| |
Aliases
for CNOT1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| CCR4-NOT Transcription Complex, Subunit 11 2 | | CCR4-Associated Factor 12 3 | | NOT11 2 3 5 | | AD-0051 | | CDC391 2 3 | | Adrenal Gland Protein AD-0052 | | NOT1H1 2 3 | | CCR4-NOT Transcription Complex Subunit 12 | | KIAA10071 3 | | NOT1 (Negative Regulator Of Transcription 1, Yeast) Homolog2 | | Negative Regulator Of Transcription Subunit 1 Homolog2 3 | | HNOT11 |
Export aliases for CNOT1 gene to outside databasesPrevious GC identifers: GC00U990233 GC16M057112 GC16M044421 |
Summaries
for CNOT1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: CNOT1_HUMAN, A5YKK6Function: Belongs to the CCR4-NOT complex that functions as general transcription regulation complex. Acts as atranscriptional repressor. Represses the ligand-dependent transcriptional activation by nuclear receptors
Gene Wiki entry for CNOT1
|
Genomic Views
for CNOT1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000016.9 NC_018927.1 NT_010498.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CNOT1 gene promoter:
HNF-4alpha1 YY1 PPAR-gamma1 CBF-B CBF-A PPAR-gamma2 CBF(2) ATF En-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for CNOT1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CNOT1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 16q21 Ensembl cytogenetic band: 16q21 HGNC cytogenetic band: 16q21CNOT1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 16 GeneLoc Exon Structure GeneLoc location for GC16M058553: view genomic region
(about GC identifiers)
Start:
|
58,553,855 bp from pter |
End:
|
58,663,790 bp from pter |
Size:
|
109,936 bases |
Orientation:
|
minus strand |
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Proteins
for CNOT1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CNOT1_HUMAN, A5YKK6 (See
protein sequence)Recommended Name: CCR4-NOT transcription complex subunit 1 Size: 2376 amino acids; 266939 Da
Subunit: Subunit of the CCR4-NOT core complex that contains CNOT1, CNOT2, CNOT3, CNOT4 and CNOT8. Interacts in aligand-dependent fashion with ESR1 and RXRA. Interacts with NANOS2 (By similarity)
Subcellular location: Cytoplasm, P-body (By similarity). Note=NANOS2 promotes its localization to P-body (Bysimilarity)
Sequence caution: Sequence=AAF14861.1; Type=Frameshift; Positions=1969, 2273; Sequence=CAH18093.1; Type=Erroneousinitiation; Note=Translation N-terminally extended;
2 PDB 3D structures from  and Proteopedia  for CNOT1:4GMJ (3D)
4GML (3D)
Secondary accessions: Q68DX7 Q7Z3K2 Q8IWB8 Q8TB53 Q9BVZ6 Q9UFR8 Q9UI27 Q9Y2L0Alternative splicing: 4 isoforms: A5YKK6-1 A5YKK6-2 A5YKK6-3 A5YKK6-4 Explore the universe of human proteins at neXtProt for CNOT1: NX_A5YKK6
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_A5YKK6
CNOT1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001252541.1 NP_057368.3 NP_996882.1
ENSEMBL proteins: ENSP00000320949 ENSP00000455635 ENSP00000456649 ENSP00000454611 ENSP00000457173 ENSP00000413113 ENSP00000454763 ENSP00000458057 ENSP00000456131 ENSP00000454377 ENSP00000457460 ENSP00000456975 ENSP00000455289 ENSP00000457869 ENSP00000245138 Reactome Protein details: A5YKK6
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
CNOT1 for ontologies About GeneDecksing
CNOT1 Antibody Products:
Assay Products for CNOT1: |
Protein
Domains /
Families
for CNOT1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CNOT1 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry A5YKK6ProtoNet protein and cluster: A5YKK6 UniProtKB/Swiss-Prot: CNOT1_HUMAN, A5YKK6Similarity: Belongs to the CNOT1 family |
Function
for CNOT1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: CNOT1_HUMAN, A5YKK6Function: Belongs to the CCR4-NOT complex that functions as general transcription regulation complex. Acts as atranscriptional repressor. Represses the ligand-dependent transcriptional activation by nuclear receptors
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CNOT1 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CNOT1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): CNOT1 (NM_206999) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CNOT1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CNOT1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CNOT1 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table
CNOT1 for ontologies About GeneDecksing
5 GenomeRNAi human phenotypes for CNOT1:
|
Pathways & Interactions
for CNOT1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Deadenylation-dependent mRNA decay | | | 2 | Metabolism of mRNA | | | 3 | Generic Transcription Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5 
Reactome Pathways for CNOT1
1 
Kegg Pathway (Kegg details for CNOT1):
CNOT1 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CNOT1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/103 Interacting proteins for CNOT1 (A5YKK61, 3 ENSP000003209494) via UniProtKB, MINT, STRING, and/or I2D (see all 103)About this table
Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000288 | nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay |
TAS | -- | | GO:0000289 | nuclear-transcribed mRNA poly(A) tail shortening |
TAS | -- | | GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- | | GO:0010467 | gene expression |
TAS | -- |
CNOT1 for ontologies About GeneDecksing
|
Drugs & Compounds
for CNOT1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CNOT1
Search CenterWatch for drugs/clinical trials and news about CNOT1
|
Transcripts
for CNOT1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CNOT1 gene (3 alternative transcripts): NM_001265612.1 NM_016284.4 NM_206999.2 Unigene Cluster for CNOT1: CCR4-NOT transcription complex, subunit 1 Hs.460923 [show with all ESTs]Unigene Representative Sequence: NR_04976318/23 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 23): ENST00000317147(uc010vik.2 uc002env.3 uc002enw.3 uc002enu.4 uc002enz.1)
ENST00000563130(uc002ent.3) ENST00000569240 ENST00000567188 ENST00000569924
ENST00000570139 ENST00000568917 ENST00000563283 ENST00000566240 ENST00000441024(uc002enx.3)
ENST00000567133 ENST00000567285 ENST00000569732 ENST00000562046 ENST00000569882
ENST00000565605 ENST00000564557 ENST00000569916
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CNOT1 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CNOT1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): CNOT1 (NM_206999) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CNOT1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CNOT1 |
Additional cDNA sequence: AB023224.2 AF110778.1 AK056927.1 AK075125.1 AK300281.1 AK301092.1 AK302495.1 AL117492.1 AL832769.1 AL833549.1 BC000779.2 BC011861.2 BC024317.1 BC027969.2 BC040523.1 BX537840.1 BX647815.1 CR749237.1 EF553522.1 NR_049763.1 24/25 DOTS entries (see all 25): DT.119935 DT.100878056 DT.100878052 DT.95315571 DT.100878055 DT.91776456 DT.95337584 DT.95337585 DT.100802806 DT.92415399 DT.120655354 DT.100721201 DT.100849743 DT.100878051 DT.100878053 DT.120655393 DT.120655429 DT.91776454 DT.91996913 DT.120655339 DT.120655381 DT.40107045 DT.40254029 DT.75109778 24/558 AceView cDNA sequences (see all 558): AA612950 AA768038 AK056927 BQ434013 AA811665 AL046037 AA806166 CD358911 BG108242 AA789010 BU175362 CD370327 CB158338 NM_016284 BM818065 AI936785 AK092885 BM449720 BM453794 BC024317 BX647815 BQ072037 BM793411 BU187992
GeneLoc Exon Structure
5/20 Alternative Splicing Database (ASD) splice patterns (SP) for CNOT1 (see all 20) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ |
|---|
|
| SP1: | | | | | | | | | - | | - | | - | | - | | - | | - | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | - | | - | | - | | - | | - | | - | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | - | | - | | - | | - | | - | | - | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | - | | - | | - | | - | | - | | - | | | | | | - | | | | | | | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | |
| ExUns: | 17a | · | 17b | · | 17c | ^ | 18a | · | 18b | ^ | 19 | ^ | 20 | ^ | 21 | ^ | 22a | · | 22b | ^ | 23a | · | 23b | ^ | 24 | ^ | 25 | ^ | 26 | ^ | 27a | · | 27b | ^ | 28 | ^ | 29a | · | 29b | ^ | 30 | ^ | 31 | ^ | 32 | ^ | 33 | ^ | 34 | ^ | 35a | · |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | - | | - | | - | | - | | - | |
| ExUns: | 35b | · | 35c | ^ | 36 | ^ | 37 | ^ | 38 | ^ | 39 | ^ | 40a | · | 40b | ^ | 41 | ^ | 42a | · | 42b | ^ | 43 | ^ | 44 | ^ | 45a | · | 45b | · | 45c | ^ | 46a | · | 46b | ^ | 47a | · | 47b | ^ | 48a | · | 48b | ^ | 49 | ^ | 50 | ^ | 51 | ^ | 52 | ^ |
|---|
|
| SP1: | | | - | | - | | | | | | | | - | | | | | | | | | | | | | | | | | | - | | | | | | - | | | | | | | | - | | | | | | | | |
| SP2: | | | - | | - | | | | | | | | - | | | | | | | | | | | | | | | | | | - | | | | | | - | | | | | | | | - | | | | | | - | | |
| SP3: | | | - | | - | | | | | | | | - | | | | | | | | | | | | | | | | | | - | | | | | | - | | | | | | | | - | | | | | | - | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | | | - | | | | | | | | - | | | | | | - | |
| ExUns: | 53 | ^ | 54 | ^ | 55 | ^ | 56 | ^ | 57a | · | 57b | · | 57c | · |
|---|
|
| SP1: | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for CNOT1
|
Expression
for CNOT1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CNOT1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAAGAGAAAA
About this image
See CNOT1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CNOT1
SOURCE GeneReport for Unigene cluster: Hs.460923
UniProtKB/Swiss-Prot: CNOT1_HUMAN, A5YKK6Tissue specificity: Strongly expressed in brain, heart, thymus, spleen, kidney, liver, placenta and lung. Weaklyexpressed in skeletal muscle and colon
SABiosciences Custom PCR Arrays for CNOT1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CNOT1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CNOT1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CNOT1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CNOT1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CNOT1 |
Orthologs
for CNOT1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for CNOT1 gene from 9/36 species (see all 36) About this table
ENSEMBL Gene Tree for CNOT1 (if available)
TreeFam Gene Tree for CNOT1 (if available) |
Paralogs
for CNOT1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for CNOT1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 16 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CNOT1 (58553855 - 58663790 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 15 variations for CNOT1
10 CNVs: 67008 102293 4008 7122 77359 5829 88149 30785 102295 58765
5 Indels: 77360 41758 45445 88150 102294 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CNOT1 |
|
Disorders
/ Diseases
for CNOT1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CNOT1 for disorders About GeneDecksing
OMIM gene information: 604917
OMIM disorders: --
4  diseases for CNOT1: About MalaCardsmyocardial stunning intrahepatic cholangiocarcinoma cholangiocarcinoma malaria
Export disorders for CNOT1 gene to outside databases
|
Publications
for CNOT1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CNOT1 gene, integrated from 9 sources (see all 41):
(articles sorted by number of sources associating them with CNOT1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Human Ccr4-Not complex is a ligand-dependent repressor of nuclear receptor-mediated transcription. (PubMed id 16778766)1, 2 Winkler G.S.... Timmers H.T. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 3 Ota T.... Sugano S. (2004)
- Isolation and characterization of human orthologs of yeast CCR4-NOT complex subunits. (PubMed id 10637334)1, 2 Albert T.K....Timmers H.T. (2000)
- Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10231032)1, 2 Nagase T.... Ohara O. (1999)
- Purification and characterization of the 1.0 MDa CCR4-NOT complex identifies two novel components of the complex. (PubMed id 11733989)1, 9 Chen J....Denis C.L. (2001)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Cnot1, Cnot2, and Cnot3 maintain mouse and human ESC i dentity and inhibit extraembryonic differentiation. (PubMed id 22367759)1 Zheng X....Hu G. (2012)
- The structural basis for the interaction between the C AF1 nuclease and the NOT1 scaffold of the human CCR4-NOT deadenylase complex. (PubMed id 22977175)1 Petit A.P....Weichenrieder O. (2012)
- A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
- A common variant in SLC8A1 is associated with the dura tion of the electrocardiographic QT interval. (PubMed id 22726844)1 Kim J.W....Oh B. (2012)
|
External Searches for CNOT1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CNOT1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
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Other Databases showing CNOT1 gene
(According to HUGE)
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Specialized Databases showing CNOT1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Name | Description |
| PharmGKB entry for CNOT1 | Pharmacogenomics, SNPs, Pathways |
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| Patent Information for CNOT1 gene:
Search GeneIP for patents involving CNOT1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for CNOT1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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| | |  | Browse OriGene Antibodies | | Browse OriGene shRNA RFPs | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CNOT1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CNOT1 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CNOT1 | | OriGene 3'-UTR Clone for CNOT1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CNOT1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CNOT1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for CNOT1 | | OriGene Custom Protein Services for CNOT1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CNOT1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CNOT1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CNOT1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CNOT1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CNOT1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CNOT1 |
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| | | | Search Tocris compounds for CNOT1 |
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 | | | CNOT1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CNOT1 |
|  |  |  | | | | Search ThermoFisher Antibodies for CNOT1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CNOT1 |
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