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Aliases for CNOT1 Gene

Aliases for CNOT1 Gene

  • CCR4-NOT Transcription Complex Subunit 1 2 3 5
  • Negative Regulator Of Transcription Subunit 1 Homolog 3 4
  • CCR4-Associated Factor 1 3 4
  • CDC39 3 4
  • NOT1H 3 4
  • NOT1 3 4
  • NOT1 (Negative Regulator Of Transcription 1, Yeast) Homolog 3
  • CCR4-NOT Transcription Complex, Subunit 1 2
  • Adrenal Gland Protein AD-005 3
  • KIAA1007 4
  • AD-005 3
  • HNOT1 4

External Ids for CNOT1 Gene

Previous HGNC Symbols for CNOT1 Gene

  • NOT1

Previous GeneCards Identifiers for CNOT1 Gene

  • GC00U990233
  • GC16M057112
  • GC16M058553
  • GC16M044421

Summaries for CNOT1 Gene

GeneCards Summary for CNOT1 Gene

CNOT1 (CCR4-NOT Transcription Complex Subunit 1) is a Protein Coding gene. Diseases associated with CNOT1 include Iritis. Among its related pathways are TP53 Regulates Transcription of Cell Cycle Genes and Regulation of TP53 Activity. GO annotations related to this gene include poly(A) RNA binding and protein domain specific binding.

UniProtKB/Swiss-Prot for CNOT1 Gene

  • Scaffolding component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Its scaffolding function implies its interaction with the catalytic complex module and diverse RNA-binding proteins mediating the complex recruitment to selected mRNA 3UTRs. Involved in degradation of AU-rich element (ARE)-containing mRNAs probably via association with ZFP36. Mediates the recruitment of the CCR4-NOT complex to miRNA targets and to the RISC complex via association with TNRC6A, TNRC6B or TNRC6C. Acts as a transcriptional repressor. Represses the ligand-dependent transcriptional activation by nuclear receptors. Involved in the maintenance of emryonic stem (ES) cell identity.

Gene Wiki entry for CNOT1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CNOT1 Gene

Genomics for CNOT1 Gene

Regulatory Elements for CNOT1 Gene

Enhancers for CNOT1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around CNOT1 on UCSC Golden Path with GeneCards custom track

Promoters for CNOT1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for CNOT1 Gene

Chromosome:
16
Start:
58,519,946 bp from pter
End:
58,629,886 bp from pter
Size:
109,941 bases
Orientation:
Minus strand

Genomic View for CNOT1 Gene

Genes around CNOT1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CNOT1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CNOT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CNOT1 Gene

Proteins for CNOT1 Gene

  • Protein details for CNOT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A5YKK6-CNOT1_HUMAN
    Recommended name:
    CCR4-NOT transcription complex subunit 1
    Protein Accession:
    A5YKK6
    Secondary Accessions:
    • Q68DX7
    • Q7Z3K2
    • Q8IWB8
    • Q8TB53
    • Q9BVZ6
    • Q9UFR8
    • Q9UI27
    • Q9Y2L0

    Protein attributes for CNOT1 Gene

    Size:
    2376 amino acids
    Molecular mass:
    266939 Da
    Quaternary structure:
    • Component of the CCR4-NOT complex; distinct complexes seem to exist that differ in the participation of probably mutually exclusive catalytic subunits. In the complex, interacts directly with CNOT6, CNOT6L, CNOT7 or CNOT8. Interacts in a ligand-dependent fashion with ESR1 and RXRA. Interacts with NANOS2, TOB1 and ZFP36. Interacts with TNRC6A, TNRC6B or TNRC6C; the interactions are direct.
    SequenceCaution:
    • Sequence=AAF14861.1; Type=Frameshift; Positions=1969, 2273; Evidence={ECO:0000305}; Sequence=CAH18093.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CNOT1 Gene

    Alternative splice isoforms for CNOT1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CNOT1 Gene

Post-translational modifications for CNOT1 Gene

  • Ubiquitination at Lys 1163 and Lys 2086
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CNOT1 Gene

Domains & Families for CNOT1 Gene

Gene Families for CNOT1 Gene

Protein Domains for CNOT1 Gene

Graphical View of Domain Structure for InterPro Entry

A5YKK6

UniProtKB/Swiss-Prot:

CNOT1_HUMAN :
  • Contains Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs, a motif known to be important for the association with nuclear receptors.
  • Belongs to the CNOT1 family.
Domain:
  • Contains Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs, a motif known to be important for the association with nuclear receptors.
Family:
  • Belongs to the CNOT1 family.
genes like me logo Genes that share domains with CNOT1: view

Function for CNOT1 Gene

Molecular function for CNOT1 Gene

UniProtKB/Swiss-Prot Function:
Scaffolding component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Its scaffolding function implies its interaction with the catalytic complex module and diverse RNA-binding proteins mediating the complex recruitment to selected mRNA 3UTRs. Involved in degradation of AU-rich element (ARE)-containing mRNAs probably via association with ZFP36. Mediates the recruitment of the CCR4-NOT complex to miRNA targets and to the RISC complex via association with TNRC6A, TNRC6B or TNRC6C. Acts as a transcriptional repressor. Represses the ligand-dependent transcriptional activation by nuclear receptors. Involved in the maintenance of emryonic stem (ES) cell identity.

Gene Ontology (GO) - Molecular Function for CNOT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004535 contributes_to poly(A)-specific ribonuclease activity IDA 21976065
GO:0005515 protein binding IPI 10637334
GO:0019904 protein domain specific binding IPI 24768540
GO:0030331 estrogen receptor binding IDA 16778766
GO:0032947 protein complex scaffold IDA 22977175
genes like me logo Genes that share ontologies with CNOT1: view
genes like me logo Genes that share phenotypes with CNOT1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for CNOT1

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CNOT1 Gene

Localization for CNOT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CNOT1 Gene

Cytoplasm, P-body. Nucleus. Note=NANOS2 promotes its localization to P-body. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CNOT1 Gene COMPARTMENTS Subcellular localization image for CNOT1 gene
Compartment Confidence
cytosol 5
extracellular 5
peroxisome 5
nucleus 4
endoplasmic reticulum 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CNOT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000932 cytoplasmic mRNA processing body ISS --
GO:0005615 extracellular space IDA 22664934
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with CNOT1: view

Pathways & Interactions for CNOT1 Gene

genes like me logo Genes that share pathways with CNOT1: view

Gene Ontology (GO) - Biological Process for CNOT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 16778766
GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening TAS --
GO:0006351 transcription, DNA-templated IEA --
GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest TAS --
GO:0007275 multicellular organism development IEA --
genes like me logo Genes that share ontologies with CNOT1: view

No data available for SIGNOR curated interactions for CNOT1 Gene

Drugs & Compounds for CNOT1 Gene

No Compound Related Data Available

Transcripts for CNOT1 Gene

Unigene Clusters for CNOT1 Gene

CCR4-NOT transcription complex, subunit 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for CNOT1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CNOT1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^
SP1: - - - - - - -
SP2: - - - - - - -
SP3:
SP4: - - - - - - -
SP5: - - - - - - - - - - - - - - - - -
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12: - - - - -
SP13: - - - -
SP14:
SP15:
SP16: - - - - -
SP17:
SP18: - - -
SP19: - - - - - -
SP20: - - -

ExUns: 17a · 17b · 17c ^ 18a · 18b ^ 19 ^ 20 ^ 21 ^ 22a · 22b ^ 23a · 23b ^ 24 ^ 25 ^ 26 ^ 27a · 27b ^ 28 ^ 29a · 29b ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35a ·
SP1: -
SP2:
SP3: -
SP4:
SP5: - - - - - - - - -
SP6:
SP7: - - - - - - - - - - - - -
SP8:
SP9: -
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:

ExUns: 35b · 35c ^ 36 ^ 37 ^ 38 ^ 39 ^ 40a · 40b ^ 41 ^ 42a · 42b ^ 43 ^ 44 ^ 45a · 45b · 45c ^ 46a · 46b ^ 47a · 47b ^ 48a · 48b ^ 49 ^ 50 ^ 51 ^ 52 ^
SP1: - - - - - -
SP2: - - - - - - -
SP3: - - - - - - -
SP4:
SP5: - - - - - - - - - - - - - - - - - - - -
SP6: - -
SP7: - - - - - - - -
SP8:
SP9:
SP10: -
SP11: - -
SP12:
SP13:
SP14: -
SP15: -
SP16:
SP17:
SP18:
SP19:
SP20:

ExUns: 53 ^ 54 ^ 55 ^ 56 ^ 57a · 57b · 57c ·
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:

Relevant External Links for CNOT1 Gene

GeneLoc Exon Structure for
CNOT1
ECgene alternative splicing isoforms for
CNOT1

Expression for CNOT1 Gene

mRNA expression in normal human tissues for CNOT1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CNOT1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (10.1), Lymph node (7.8), and Bone (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CNOT1 Gene



Protein tissue co-expression partners for CNOT1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CNOT1 Gene:

CNOT1

SOURCE GeneReport for Unigene cluster for CNOT1 Gene:

Hs.460923

mRNA Expression by UniProt/SwissProt for CNOT1 Gene:

A5YKK6-CNOT1_HUMAN
Tissue specificity: Strongly expressed in brain, heart, thymus, spleen, kidney, liver, placenta and lung. Weakly expressed in skeletal muscle and colon.
genes like me logo Genes that share expression patterns with CNOT1: view

Primer Products

No data available for mRNA differential expression in normal tissues for CNOT1 Gene

Orthologs for CNOT1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CNOT1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CNOT1 34
  • 95.26 (n)
  • 99.75 (a)
CNOT1 35
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CNOT1 34
  • 95.06 (n)
  • 99.71 (a)
CNOT1 35
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cnot1 34
  • 92.35 (n)
  • 99.37 (a)
Cnot1 16
Cnot1 35
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CNOT1 34
  • 99.87 (n)
  • 100 (a)
CNOT1 35
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cnot1 34
  • 91.75 (n)
  • 99.33 (a)
oppossum
(Monodelphis domestica)
Mammalia CNOT1 35
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 86 (a)
OneToMany
-- 35
  • 98 (a)
OneToMany
chicken
(Gallus gallus)
Aves CNOT1 34
  • 86.15 (n)
  • 97.73 (a)
-- 35
  • 100 (a)
OneToMany
CNOT1 35
  • 98 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia CNOT1 35
  • 95 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cnot1 34
  • 80.41 (n)
  • 93.99 (a)
zebrafish
(Danio rerio)
Actinopterygii cnot1 34
  • 77.76 (n)
  • 90.52 (a)
cnot1 35
  • 91 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8458 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009057 34
  • 55.05 (n)
  • 54.89 (a)
fruit fly
(Drosophila melanogaster)
Insecta Not1 34
  • 53.53 (n)
  • 51.12 (a)
Not1 35
  • 47 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea let-711 34
  • 51.32 (n)
  • 44.68 (a)
let-711 35
  • 32 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CDC39 35
  • 26 (a)
OneToOne
CDC39 37
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G02080 34
  • 50.16 (n)
  • 39.24 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.11667 34
barley
(Hordeum vulgare)
Liliopsida Hv.4407 34
rice
(Oryza sativa)
Liliopsida Os.4089 34
Os10g0556801 34
  • 51.04 (n)
  • 42.12 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.5541 34
corn
(Zea mays)
Liliopsida Zm.7360 34
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3300 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6570 35
  • 60 (a)
OneToOne
Species where no ortholog for CNOT1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for CNOT1 Gene

ENSEMBL:
Gene Tree for CNOT1 (if available)
TreeFam:
Gene Tree for CNOT1 (if available)

Paralogs for CNOT1 Gene

No data available for Paralogs for CNOT1 Gene

Variants for CNOT1 Gene

Sequence variations from dbSNP and Humsavar for CNOT1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs17854028 - 58,575,026(+) TTTTA(G/T)CTGTG nc-transcript-variant, reference, missense
rs3045182 -- 58,554,939(+) caaaa(-/G/GAAAAAAA)aaaaa intron-variant
rs3045184 -- 58,563,102(+) ACGCG(-/TT)GTTTT intron-variant
rs3048056 -- 58,529,811(+) CTCCA(-/CTCCA)GCCTG intron-variant
rs3180805 -- 58,543,452(-) TAATT(C/T)TGTGA intron-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for CNOT1 Gene

Variant ID Type Subtype PubMed ID
dgv482n67 CNV loss 20364138
dgv497e199 CNV deletion 23128226
dgv5151n54 CNV loss 21841781
dgv5152n54 CNV gain 21841781
dgv5153n54 CNV gain+loss 21841781
dgv5154n54 CNV gain 21841781
dgv5155n54 CNV loss 21841781
dgv5156n54 CNV loss 21841781
dgv5157n54 CNV gain 21841781
dgv59e180 CNV gain 20482838
esv2032869 CNV deletion 18987734
esv2466145 CNV insertion 19546169
esv24929 CNV gain 19812545
esv2546975 CNV deletion 19546169
esv2614548 CNV deletion 19546169
esv2714553 CNV deletion 23290073
esv2714554 CNV deletion 23290073
esv2714555 CNV deletion 23290073
esv2714556 CNV deletion 23290073
esv2758650 CNV loss 17122850
esv32972 CNV gain+loss 17666407
esv3553495 CNV deletion 23714750
esv3638729 CNV loss 21293372
esv4241 CNV loss 18987735
nsv103378 CNV deletion 16902084
nsv103597 CNV deletion 16902084
nsv1071009 CNV deletion 25765185
nsv1113813 CNV deletion 24896259
nsv1126430 CNV deletion 24896259
nsv507819 OTHER sequence alteration 20534489
nsv509623 CNV insertion 20534489
nsv510686 CNV deletion 20534489
nsv511049 OTHER complex 20534489
nsv512440 CNV loss 21212237
nsv514806 CNV loss 21397061
nsv521338 CNV loss 19592680
nsv572769 CNV gain+loss 21841781
nsv572788 CNV loss 21841781
nsv819144 CNV gain 19587683
nsv821034 CNV deletion 20802225
nsv827687 CNV loss 20364138
nsv9448 CNV gain 18304495
nsv958053 CNV deletion 24416366

Variation tolerance for CNOT1 Gene

Residual Variation Intolerance Score: 0.464% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.12; 38.62% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CNOT1 Gene

Human Gene Mutation Database (HGMD)
CNOT1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CNOT1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CNOT1 Gene

Disorders for CNOT1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CNOT1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
iritis
  • anterior uveitis
- elite association - COSMIC cancer census association via MalaCards
Search CNOT1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CNOT1

Genetic Association Database (GAD)
CNOT1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CNOT1
genes like me logo Genes that share disorders with CNOT1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CNOT1 Gene

Publications for CNOT1 Gene

  1. Structural basis for the recruitment of the human CCR4-NOT deadenylase complex by tristetraprolin. (PMID: 23644599) Fabian M.R. … Sonenberg N. (Nat. Struct. Mol. Biol. 2013) 3 4 65
  2. Cnot1, Cnot2, and Cnot3 maintain mouse and human ESC identity and inhibit extraembryonic differentiation. (PMID: 22367759) Zheng X. … Hu G. (Stem Cells 2012) 3 4 65
  3. The structural basis for the interaction between the CAF1 nuclease and the NOT1 scaffold of the human CCR4-NOT deadenylase complex. (PMID: 22977175) Petit A.P. … Weichenrieder O. (Nucleic Acids Res. 2012) 3 4 65
  4. Not1 mediates recruitment of the deadenylase Caf1 to mRNAs targeted for degradation by tristetraprolin. (PMID: 21278420) Sandler H. … Stoecklin G. (Nucleic Acids Res. 2011) 3 4 65
  5. The role of the CNOT1 subunit of the CCR4-NOT complex in mRNA deadenylation and cell viability. (PMID: 21976065) Ito K. … Yamamoto T. (Protein Cell 2011) 3 4 65

Products for CNOT1 Gene

Sources for CNOT1 Gene

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