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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CNNM4 Gene

protein-coding GIFtS: 51
GCID: GC02P097426

cyclin M4

(Previous symbol: ACDP4)

Explore 10 diseases affiliated with
CNNM4 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Cyclin M4¹ ²		Ancient Conserved Domain Protein 4²
ACDP4¹ ² ³ ⁵		Cyclin-M4³
KIAA1592¹ ³		Metal Transporter CNNM4²
Ancient Conserved Domain-Containing Protein 4² ³		Cyclin-M4³

External Ids:	HGNC: 105¹	Entrez Gene: 26504²	Ensembl: ENSG00000158158⁷	OMIM: 607805⁵	UniProtKB: Q6P4Q7³

Export aliases for CNNM4 gene to outside databases

Previous GC identifers: GC02P095298 GC02P095882 GC02P096894 GC02P096911 GC02P096848 GC02P096790 GC02P091387

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CNNM4:

This gene encodes a member of the ancient conserved domain containing protein family. Members of this protein family

contain a cyclin box motif and have structural similarity to the cyclins. The encoded protein may play a role in metal

ion transport. Mutations in this gene are associated with Jalili syndrome which consists of cone-rod dystrophy and

amelogenesis imperfecta. (provided by RefSeq, Feb 2010)

UniProtKB/Swiss-Prot: CNNM4_HUMAN, Q6P4Q7

Function: Probable metal transporter. The interaction with the metal ion chaperone COX11 suggests that it may play a

role in sensory neuron functions (By similarity). May play a role in biomineralization and retinal function

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000002.11 NC_018913.1 NT_022171.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CNNM4 gene promoter:
COUP-TF1 RP58 AML1a HTF COUP HNF-4alpha2 HNF-4alpha1 N-Myc COUP-TF
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CNNM4 promoter sequence

Search SABiosciences Chromatin IP Primers for CNNM4

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CNNM4

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q11 Ensembl cytogenetic band: 2q11.2 HGNC cytogenetic band: 2q11.2

CNNM4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CNNM4 gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02P097426: view genomic region (about GC identifiers)

Start:	97,426,639 bp from pter	End:	97,477,628 bp from pter
Size:	50,990 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CNNM4_HUMAN, Q6P4Q7 (See protein sequence)

Recommended Name: Metal transporter CNNM4

Size: 775 amino acids; 86607 Da

Subunit: Interacts with COX11

Subcellular location: Cell membrane; Multi-pass membrane protein

Miscellaneous: Shares weak sequence similarity with the cyclin family, explaining its name. However, it has no

cyclin-like function in vivo

Sequence caution: Sequence=AAF86370.1; Type=Frameshift; Positions=108, 120; Sequence=AAY14963.1; Type=Erroneous

initiation; Note=Translation N-terminally extended; Sequence=BAB14266.1; Type=Erroneous initiation; Note=Translation

N-terminally extended;

Secondary accessions: Q53RE5 Q9H9G3 Q9HCI0 Q9NRN1

Explore the universe of human proteins at neXtProt for CNNM4: NX_Q6P4Q7

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q6P4Q7

CNNM4 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_064569.3

ENSEMBL proteins:

ENSP00000366275 ENSP00000444806

Human Recombinant Protein Products:

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	Novus Biologicals CNNM4 Protein
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	Browse ProSpec Recombinant Proteins
	Uscn Proteins for CNNM4

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	IEA	--
GO:0016021	integral to membrane	IEA	--

CNNM4 for ontologies About GeneDecksing

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	ThermoFisher Antibodies for CNNM4

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	Uscn ELISAs and CLIAs for CNNM4

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CNNM4 for domains About GeneDecksing

4 InterPro domains/families:

IPR000644 Cysta_beta_synth_core

IPR000595 cNMP-bd_dom

IPR002550 DUF21

IPR014710 RmlC-like_jellyroll

Graphical View of Domain Structure for InterPro Entry Q6P4Q7

ProtoNet protein and cluster: Q6P4Q7

3 Blocks protein families:

IPB000595 Cyclic nucleotide-binding domain

IPB000644 CBS domain

IPB002550 CBS

UniProtKB/Swiss-Prot: CNNM4_HUMAN, Q6P4Q7

Similarity: Belongs to the ACDP family

Similarity: Contains 2 CBS domains

Similarity: Contains 1 DUF21 domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: CNNM4_HUMAN, Q6P4Q7

Function: Probable metal transporter. The interaction with the metal ion chaperone COX11 suggests that it may play a

role in sensory neuron functions (By similarity). May play a role in biomineralization and retinal function

miRNA Products:		OriGene 3'-UTR Clone: CNNM4 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CNNM4
		8/57 QIAGEN miScript miRNA Assays for microRNAs that regulate CNNM4 (see all 57):
		hsa-miR-2052 hsa-miR-142-5p hsa-miR-19b-2* hsa-miR-300 hsa-miR-24-1* hsa-miR-25 hsa-miR-1258 hsa-miR-9

		SwitchGear 3'UTR luciferase reporter plasmid: CNNM4 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CNNM4 (see all 4) OriGene shRNA RFP: CNNM4 OriGene siRNA: CNNM4
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Gene Editing
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		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CNNM4 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CNNM4 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CNNM4
		Search LifeMap BioReagents cell lines for CNNM4

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CNNM4

1 GenomeRNAi human phenotype for CNNM4:

Decreased circadian period len

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for CNNM4

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

1 Interacting protein for CNNM4 (Q6P4Q7³ ENSP00000366275⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PTP4A2	Q12974³, ENSP00000344909⁴	I2D: score=1 STRING: ENSP00000344909

About this table

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006811	ion transport	IEA	--
GO:0007601	visual perception	IEA	--
GO:0031214	biomineral tissue development	IEA	--
GO:0050896	response to stimulus	IEA	--

CNNM4 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CNNM4
Search CenterWatch for drugs/clinical trials and news about CNNM4

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CNNM4 gene:

NM_020184.3

Unigene Cluster for CNNM4:

Cyclin M4

Hs.175043 [show with all ESTs]

Unigene Representative Sequence: BC063295

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000377075(uc002swx.3) ENST00000482716 ENST00000496186 ENST00000493384

ENST00000540067(uc010yuy.2)

miRNA Products:		OriGene 3'-UTR Clone: CNNM4 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CNNM4
		8/57 QIAGEN miScript miRNA Assays for microRNAs that regulate CNNM4 (see all 57):
		hsa-miR-2052 hsa-miR-142-5p hsa-miR-19b-2* hsa-miR-300 hsa-miR-24-1* hsa-miR-25 hsa-miR-1258 hsa-miR-9

		SwitchGear 3'UTR luciferase reporter plasmid: CNNM4 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CNNM4 (see all 4) OriGene shRNA RFP: CNNM4 OriGene siRNA: CNNM4
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CNNM4

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CNNM4 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CNNM4 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: CNNM4 (NM_020184)
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Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CNNM4 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CNNM4
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CNNM4

Additional cDNA sequence:

AB046812.1 AF202777.1 AK022833.1 AK095065.1 AK293915.1 AL833905.1 BC063295.1

4 DOTS entries:

DT.440749 DT.99949719 DT.40195286 DT.92423031

24/113 AceView cDNA sequences (see all 113):

AI250061 AI784226 BE549578 AA682741 AI203318 BM767356 AW193818 AL833905

AU124719 BU728717 BM980392 BM770848 AA633378 CA443913 AI086161 R79035

AK095065 AI215435 AI082229 BM770528 AA631999 BM770248 AA458941 BC063295

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CNNM4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTGGTCCTTC

About this image

CNNM4 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Definitive endoderm-like cells (A scalable, suspensi...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See CNNM4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CNNM4

SOURCE GeneReport for Unigene cluster: Hs.175043

UniProtKB/Swiss-Prot: CNNM4_HUMAN, Q6P4Q7

Tissue specificity: Widely expressed. Highly expressed in heart

SABiosciences Custom PCR Arrays for CNNM4

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CNNM4

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CNNM4

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for CNNM4 gene from 7/25 species (see all 25) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	LOC425706¹	metal transporter CNNM4-like	72.69(n) 72.32(a)		425706 XM_003643431.1 XP_003643479.1
lizard (Anolis carolinensis)	Reptilia	CNNM4⁶ --	--	64(a) 57(a)	1 ↔ many 1 ↔ many	GL343484.1(531938-580868) GL343488.1(253793-265126)
zebrafish (Danio rerio)	Actinopterygii	LOC100150651¹	novel protein similar to human and mouse cyclin M4 more	66.67(n) 68.73(a)		100150651 XM_001919506.2 XP_001919541.2
fruit fly (Drosophila melanogaster)	Insecta	uex⁶	unextended	37(a)	1 → many	2RHet(3136909-3181390)
worm (Caenorhabditis elegans)	Secernentea	C33D12.2³ CELE_C52D10.12¹	Protein C52D10.12¹	46(a) (best of 3)³ 47.55(n)¹ 38.74(a)¹		X(3077278-3081092)³ 178499¹ NM_070651.2¹ NP_503052.1¹
thale cress (Arabidopsis thaliana)	eudicotyledons	AT2G14520⁶ AT4G33700⁶ (see all 7)	CBS domain-containing protein (see all 7)	29(a) 28(a) (see all 7)	possible ortholog possible ortholog (see all 7)	2(6182193-6184648) 4(16176276-16179481)
rice (Oryza sativa)	Liliopsida	-- -- (see all 3)	CBS domain containing protein, expressed (see all 3)	28(a) 26(a) (see all 3)	possible ortholog possible ortholog (see all 3)	3(26644652-26650901) 5(19170330-19177914)

ENSEMBL Gene Tree for CNNM4 (if available)
TreeFam Gene Tree for CNNM4 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CNNM4 gene

CNNM1² CNNM3² CNNM2²

4 SIMAP similar genes for CNNM4 using alignment to 5 protein entries: CNNM4_HUMAN (see all proteins):

CNNM1 DKFZp434I1016 CNNM2 CNNM3

CNNM4 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs79424354^1,2	C	pathogenic	97427335(+)	`ATTTTA/CTGGCC`	2	Y S	mis¹		0	--	--	--	--
rs75267011^1,2	C	pathogenic	97427443(+)	`CATCCA/GGCGCA`	2	Q R	mis¹		0	--	--	--	--
rs74552543^1,2	C	pathogenic	97427707(+)	`GCTCCC/TGGACT`	2	P L	mis¹		0	--	--	--	--
rs80100937^1,2	C	pathogenic	97464802(+)	`TCTCTC/TAGTTT`	2	Q *	stg¹		0	--	--	--	--
rs75559353^1,2	C	pathogenic	97475075(+)	`AGTACC/TAGAAC`	2	Q *	stg¹		0	--	--	--	--
rs11888876^1,2	C,F,H,	--	91438286(+)	`GTGCTC/TAGCTG`	1	--	ds500¹		8		NS NA WA	1090
rs117231287^1,2	F,	--	97424680(+)	`TGAGTG/ATAGAC`	1	--	us2k¹		1		EA	120
rs181879346^1,2		--	97424719(+)	`CAATTC/TGTACT`	1	--	us2k¹		0	--	--	--	--
rs186946255^1,2		--	97424820(+)	`TTCTAA/CGTATG`	1	--	us2k¹		0	--	--	--	--
rs115069125^1,2	F,	--	97424903(+)	`TTTGAG/CGCAAT`	1	--	us2k¹		1		WA	118

HapMap Linkage Disequilibrium report for CNNM4 (97426639 - 97477628 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CNNM4: --
Human Gene Mutation Database (HGMD): CNNM4

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CNNM4

DNA2.0 Custom Variant and Variant Library Synthesis for CNNM4

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CNNM4 for disorders           About GeneDecksing

OMIM gene information: 607805
OMIM disorders: 217080
UniProtKB/Swiss-Prot: CNNM4_HUMAN, Q6P4Q7

Defects in CNNM4 are the cause of Jalili syndrome (JALIS) [MIM:217080]. A syndrome characterized by the

association of cone-rod dystrophy and amelogenesis imperfecta

10 diseases for CNNM4: About MalaCards

cone-rod dystrophy amelogenesis imperfecta cone-rod dystrophy amelogenesis imperfecta achromatopsia

pneumonia retinitis tuberculosis malaria

neuronitis mycobacterium tuberculosis

2 diseases from the University of Copenhagen DISEASES database for CNNM4:

cone-rod dystrophy Amelogenesis imperfecta

Export disorders for CNNM4 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CNNM4 gene, integrated from 9 sources (see all 21):
(articles sorted by number of sources associating them with CNNM4)

Utopia: connect your pdf to the dynamic
world of online information

Mutations in CNNM4 cause recessive cone-rod dystrophy with amelogenesis imperfecta. (PubMed id 19200527)^{1, 2} Polok B....Schorderet D.F. (2009)
Mutations in CNNM4 cause Jalili syndrome, consisting of autosomal-recessive cone-rod dystrophy and amelogenesis imperfecta. (PubMed id 19200525)^{1, 2} Parry D.A....Inglehearn C.F. (2009)
Physical interaction and functional coupling between ACDP4 and the intracellular ion chaperone COX11, an implication of the role of ACDP4 in essential metal ion transport and homeostasis. (PubMed id 15840172)^{1, 2} Guo D.... Wang C.-Y. (2005)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Molecular cloning and characterization of a novel gene family of four ancient conserved domain proteins (ACDP). (PubMed id 12657465)^{1, 2} Wang C.-Y.... She J.-X. (2003)
Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10997877)^{1, 2} Nagase T.... Ohara O. (2000)
Membrane topology and intracellular processing of Cyclin M2 (CNNM2). (PubMed id 22399287)² de Baaij J.H.... Hoenderop J.G. (2012)
Cone-rod dystrophy associated with amelogenesis imperf ecta in a child with neurofibromatosis type 1. (PubMed id 21728811)¹ Zobor D....Kohl S. (2012)
Large-scale genome-wide association analysis of bipol ar disorder identifies a new susceptibility locus near ODZ4. (PubMed id 21926972)¹ Sklar P....Purcell S.M. (2011)
Purification, crystallization and preliminary crystal lographic analysis of the CBS pair of the human metal transporter CNNM4. (PubMed id 21393841)¹ GA^mez GarcA-a I....MartA-nez-Cruz L.A. (2011)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 26504	HGNC: 105	AceView: CNNM4	Ensembl:ENSG00000158158	euGenes: HUgn26504
ECgene: CNNM4	H-InvDB: CNNM4

(According to HUGE)
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HUGE: KIAA1592

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CNNM4	Pharmacogenomics, SNPs, Pathways

Intellectual Property for CNNM4 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for CNNM4 gene:
Search GeneIP for patents involving CNNM4

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
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Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

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