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Aliases for CNNM3 Gene

Aliases for CNNM3 Gene

  • Cyclin And CBS Domain Divalent Metal Cation Transport Mediator 3 2 3 5
  • Ancient Conserved Domain-Containing Protein 3 3 4
  • Cyclin M3 2 3
  • Cyclin-M3 3 4
  • ACDP3 3 4
  • Ancient Conserved Domain Protein 3 3

External Ids for CNNM3 Gene

Previous HGNC Symbols for CNNM3 Gene

  • ACDP3

Previous GeneCards Identifiers for CNNM3 Gene

  • GC02P095354
  • GC02P095936
  • GC02P096949
  • GC02P096966
  • GC02P096903
  • GC02P096845
  • GC02P097481
  • GC02P091442

Summaries for CNNM3 Gene

GeneCards Summary for CNNM3 Gene

CNNM3 (Cyclin And CBS Domain Divalent Metal Cation Transport Mediator 3) is a Protein Coding gene. GO annotations related to this gene include DNA-directed RNA polymerase activity and adenyl nucleotide binding. An important paralog of this gene is CNNM2.

UniProtKB/Swiss-Prot for CNNM3 Gene

  • Probable metal transporter.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CNNM3 Gene

Genomics for CNNM3 Gene

Regulatory Elements for CNNM3 Gene

Enhancers for CNNM3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CNNM3 on UCSC Golden Path with GeneCards custom track

Promoters for CNNM3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CNNM3 on UCSC Golden Path with GeneCards custom track

Genomic Location for CNNM3 Gene

96,814,952 bp from pter
96,837,466 bp from pter
22,515 bases
Plus strand

Genomic View for CNNM3 Gene

Genes around CNNM3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CNNM3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CNNM3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CNNM3 Gene

Proteins for CNNM3 Gene

  • Protein details for CNNM3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Metal transporter CNNM3
    Protein Accession:
    Secondary Accessions:
    • B3KX67
    • Q8TBV4
    • Q96IW4
    • Q9NRK4
    • Q9NXW6

    Protein attributes for CNNM3 Gene

    707 amino acids
    Molecular mass:
    76119 Da
    Quaternary structure:
    No Data Available
    • Shares weak sequence similarity with the cyclin family, hence its name. However, it has no cyclin-like function in vivo.
    • Sequence=AAF86377.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH07199.3; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA90891.1; Type=Frameshift; Positions=315; Evidence={ECO:0000305};

    Alternative splice isoforms for CNNM3 Gene


neXtProt entry for CNNM3 Gene

Proteomics data for CNNM3 Gene at MOPED

Post-translational modifications for CNNM3 Gene

  • Ubiquitination at Lys 462, Lys 519, Lys 526, and Lys 640
  • Glycosylation at Asn 73
  • Modification sites at PhosphoSitePlus

Other Protein References for CNNM3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CNNM3 Gene

Domains & Families for CNNM3 Gene

Protein Domains for CNNM3 Gene


Suggested Antigen Peptide Sequences for CNNM3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 2 CBS domains.
  • Belongs to the ACDP family.
  • Contains 2 CBS domains.
  • Contains 1 DUF21 domain.
  • Belongs to the ACDP family.
genes like me logo Genes that share domains with CNNM3: view

No data available for Gene Families for CNNM3 Gene

Function for CNNM3 Gene

Molecular function for CNNM3 Gene

UniProtKB/Swiss-Prot Function:
Probable metal transporter.

Phenotypes for CNNM3 Gene

GenomeRNAi human phenotypes for CNNM3:
genes like me logo Genes that share phenotypes with CNNM3: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CNNM3 Gene

Localization for CNNM3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CNNM3 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for CNNM3 Gene COMPARTMENTS Subcellular localization image for CNNM3 gene
Compartment Confidence
plasma membrane 5
cytosol 2

Gene Ontology (GO) - Cellular Components for CNNM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
genes like me logo Genes that share ontologies with CNNM3: view

Pathways & Interactions for CNNM3 Gene

SuperPathways for CNNM3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CNNM3 Gene


No data available for Pathways by source and SIGNOR curated interactions for CNNM3 Gene

Drugs & Compounds for CNNM3 Gene

No Compound Related Data Available

Transcripts for CNNM3 Gene

Unigene Clusters for CNNM3 Gene

Cyclin M3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CNNM3 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8
SP1: -
SP2: - -

Relevant External Links for CNNM3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CNNM3 Gene

mRNA expression in normal human tissues for CNNM3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CNNM3 Gene

This gene is overexpressed in Fetal Brain (19.3), Pancreas (11.3), Placenta (8.5), and Testis (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CNNM3 Gene

SOURCE GeneReport for Unigene cluster for CNNM3 Gene Hs.711617

mRNA Expression by UniProt/SwissProt for CNNM3 Gene

Tissue specificity: Widely expressed. Expressed at higher level in heart and spleen.
genes like me logo Genes that share expression patterns with CNNM3: view

Protein tissue co-expression partners for CNNM3 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues for CNNM3 Gene

Orthologs for CNNM3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CNNM3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CNNM3 35
  • 89.39 (n)
  • 91.48 (a)
CNNM3 36
  • 90 (a)
(Canis familiaris)
Mammalia CNNM3 35
  • 90.23 (n)
  • 92.31 (a)
CNNM3 36
  • 91 (a)
(Mus musculus)
Mammalia Cnnm3 35
  • 86.98 (n)
  • 88.47 (a)
Cnnm3 16
Cnnm3 36
  • 87 (a)
(Pan troglodytes)
Mammalia CNNM3 35
  • 99.53 (n)
  • 99.58 (a)
CNNM3 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Cnnm3 35
  • 86.84 (n)
  • 89.19 (a)
(Monodelphis domestica)
Mammalia CNNM3 36
  • 78 (a)
(Ornithorhynchus anatinus)
Mammalia CNNM3 36
  • 68 (a)
(Anolis carolinensis)
Reptilia CNNM3 36
  • 61 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cnnm3 35
  • 62.59 (n)
  • 61.28 (a)
(Danio rerio)
Actinopterygii LOC100329721 35
  • 62.84 (n)
  • 60.64 (a)
CABZ01071058.1 36
  • 49 (a)
fruit fly
(Drosophila melanogaster)
Insecta uex 36
  • 28 (a)
(Caenorhabditis elegans)
Secernentea C33D12.2 36
  • 23 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MAM3 36
  • 18 (a)
Species with no ortholog for CNNM3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CNNM3 Gene

Gene Tree for CNNM3 (if available)
Gene Tree for CNNM3 (if available)

Paralogs for CNNM3 Gene

Paralogs for CNNM3 Gene

(3) SIMAP similar genes for CNNM3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CNNM3: view

Variants for CNNM3 Gene

Sequence variations from dbSNP and Humsavar for CNNM3 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs938850 -- 96,822,499(-) gaccc(C/T)aatct intron-variant
rs4907251 -- 96,819,077(+) TAGCT(C/T)AGGAA intron-variant
rs4907252 -- 96,820,973(+) CGATG(C/G)AGGAG intron-variant
rs1047634 -- 96,832,920(+) TCCCC(C/T)GGGGC intron-variant, nc-transcript-variant, utr-variant-3-prime
rs1057296 -- 96,837,407(+) ATTTT(G/T)TTTTT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CNNM3 Gene

Variant ID Type Subtype PubMed ID
dgv650e201 CNV Deletion 23290073
esv5003 CNV Complex 18987735
nsv874677 CNV Loss 21882294
nsv874680 CNV Loss 21882294
nsv526313 CNV Loss 19592680
dgv4249n71 CNV Loss 21882294

Variation tolerance for CNNM3 Gene

Residual Variation Intolerance Score: 38.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.60; 30.77% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CNNM3 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CNNM3 Gene

Disorders for CNNM3 Gene

Relevant External Links for CNNM3

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CNNM3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CNNM3 Gene

Publications for CNNM3 Gene

  1. The protein tyrosine phosphatase PRL-2 interacts with the magnesium transporter CNNM3 to promote oncogenesis. (PMID: 24632616) Hardy S. … Tremblay M.L. (Oncogene 2015) 2 3 67
  2. Purification, crystallization and preliminary crystallographic analysis of the CBS pair of the human metal transporter CNNM4. (PMID: 21393841) GA^mez GarcA-a I. … MartA-nez-Cruz L.A. (Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 2011) 2 3
  3. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta G.D. … Pelletier L. (Cell 2015) 3
  4. Identifying biological pathways that underlie primordial short stature using network analysis. (PMID: 24711643) Hanson D. … Clayton P.E. (J. Mol. Endocrinol. 2014) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for CNNM3 Gene

Sources for CNNM3 Gene