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Aliases for CNNM3 Gene

Aliases for CNNM3 Gene

  • Cyclin And CBS Domain Divalent Metal Cation Transport Mediator 3 2 3 5
  • Ancient Conserved Domain-Containing Protein 3 3 4
  • Cyclin-M3 3 4
  • ACDP3 3 4
  • Ancient Conserved Domain Protein 3 3
  • Metal Transporter CNNM3 3
  • Cyclin M3 2

External Ids for CNNM3 Gene

Previous HGNC Symbols for CNNM3 Gene

  • ACDP3

Previous GeneCards Identifiers for CNNM3 Gene

  • GC02P095354
  • GC02P095936
  • GC02P096949
  • GC02P096966
  • GC02P096903
  • GC02P096845
  • GC02P097481
  • GC02P091442

Summaries for CNNM3 Gene

GeneCards Summary for CNNM3 Gene

CNNM3 (Cyclin And CBS Domain Divalent Metal Cation Transport Mediator 3) is a Protein Coding gene. GO annotations related to this gene include DNA-directed RNA polymerase activity and adenyl nucleotide binding. An important paralog of this gene is CNNM1.

UniProtKB/Swiss-Prot for CNNM3 Gene

  • Probable metal transporter.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CNNM3 Gene

Genomics for CNNM3 Gene

Regulatory Elements for CNNM3 Gene

Enhancers for CNNM3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F096615 0.6 Ensembl ENCODE 15.5 -197.0 -197047 3.8 ELF3 KLF1 SAP130 TAF1 KLF17 RAD21 RARA YY1 NFE2 NR2F6 CNNM3 ARID5A FER1L5 KANSL3 LOC105373496 CNNM4 LMAN2L ITPRIPL1 SNRNP200 GC02P096595
GH02F096747 0.2 Ensembl 10.4 -67.0 -66952 0.8 RNF2 TEAD1 HLF CEBPB CEBPG ZBTB40 ARID1B IRF9 ZNF318 JUND LMAN2L CNNM3 CNNM4
GH02F096608 0.2 ENCODE 10.2 -206.2 -206155 1.4 TFAP4 ESRRA SAP130 NR2F1 MAFG RAD21 RARA ZNF316 IKZF1 NFE2 ARID5A LOC105373496 CNNM3 KANSL3 GC02P096595 FER1L5
GH02F096593 0.6 ENCODE 10.1 -220.3 -220275 1.9 PKNOX1 CNNM3 ITPRIPL1 LOC105373495 SNRNP200 GC02P096595 GC02M096584 PIR31342
GH02F096664 1.4 FANTOM5 Ensembl ENCODE 10 -149.4 -149414 2.3 TBP PKNOX1 CBX3 RAD21 BRCA1 RFX5 ZNF366 SMARCC2 ZNF143 RCOR1 ANKRD36B CNNM4 LMAN2L CNNM3 ARID5A KANSL3 TMEM127 GC02M096702
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around CNNM3 on UCSC Golden Path with GeneCards custom track

Promoters for CNNM3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000594814 1448 2401 ATF1 ZFP64 ARID4B SIN3A DMAP1 ZNF48 YY1 ZNF121 GTF3C2 GLIS2

Genomic Location for CNNM3 Gene

96,814,952 bp from pter
96,837,466 bp from pter
22,515 bases
Plus strand

Genomic View for CNNM3 Gene

Genes around CNNM3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CNNM3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CNNM3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CNNM3 Gene

Proteins for CNNM3 Gene

  • Protein details for CNNM3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Metal transporter CNNM3
    Protein Accession:
    Secondary Accessions:
    • B3KX67
    • Q8TBV4
    • Q96IW4
    • Q9NRK4
    • Q9NXW6

    Protein attributes for CNNM3 Gene

    707 amino acids
    Molecular mass:
    76119 Da
    Quaternary structure:
    No Data Available
    • Shares weak sequence similarity with the cyclin family, hence its name. However, it has no cyclin-like function in vivo.
    • Sequence=AAF86377.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH07199.3; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA90891.1; Type=Frameshift; Positions=315; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CNNM3 Gene

    Alternative splice isoforms for CNNM3 Gene


neXtProt entry for CNNM3 Gene

Post-translational modifications for CNNM3 Gene

  • Ubiquitination at Lys 462, Lys 519, Lys 526, and Lys 640
  • Glycosylation at Asn 73
  • Modification sites at PhosphoSitePlus

Other Protein References for CNNM3 Gene

No data available for DME Specific Peptides for CNNM3 Gene

Domains & Families for CNNM3 Gene

Protein Domains for CNNM3 Gene


Suggested Antigen Peptide Sequences for CNNM3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 2 CBS domains.
  • Belongs to the ACDP family.
  • Contains 2 CBS domains.
  • Contains 1 DUF21 domain.
  • Belongs to the ACDP family.
genes like me logo Genes that share domains with CNNM3: view

No data available for Gene Families for CNNM3 Gene

Function for CNNM3 Gene

Molecular function for CNNM3 Gene

UniProtKB/Swiss-Prot Function:
Probable metal transporter.

Gene Ontology (GO) - Molecular Function for CNNM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with CNNM3: view

Phenotypes for CNNM3 Gene

genes like me logo Genes that share phenotypes with CNNM3: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CNNM3 Gene

Localization for CNNM3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CNNM3 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for CNNM3 Gene COMPARTMENTS Subcellular localization image for CNNM3 gene
Compartment Confidence
plasma membrane 5
cytosol 2

Gene Ontology (GO) - Cellular Components for CNNM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA,IDA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CNNM3: view

Pathways & Interactions for CNNM3 Gene

SuperPathways for CNNM3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CNNM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006811 ion transport IEA --
genes like me logo Genes that share ontologies with CNNM3: view

No data available for Pathways by source and SIGNOR curated interactions for CNNM3 Gene

Transcripts for CNNM3 Gene

Unigene Clusters for CNNM3 Gene

Cyclin M3:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CNNM3 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8
SP1: -
SP2: - -

Relevant External Links for CNNM3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CNNM3 Gene

mRNA expression in normal human tissues for CNNM3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CNNM3 Gene

This gene is overexpressed in Fetal Brain (19.3), Pancreas (11.3), Placenta (8.5), and Testis (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CNNM3 Gene

Protein tissue co-expression partners for CNNM3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CNNM3 Gene:


SOURCE GeneReport for Unigene cluster for CNNM3 Gene:


mRNA Expression by UniProt/SwissProt for CNNM3 Gene:

Tissue specificity: Widely expressed. Expressed at higher level in heart and spleen.
genes like me logo Genes that share expression patterns with CNNM3: view

Primer Products

No data available for mRNA differential expression in normal tissues for CNNM3 Gene

Orthologs for CNNM3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CNNM3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CNNM3 34 35
  • 99.53 (n)
(Canis familiaris)
Mammalia CNNM3 34 35
  • 90.23 (n)
(Bos Taurus)
Mammalia CNNM3 34 35
  • 89.39 (n)
(Mus musculus)
Mammalia Cnnm3 34 16 35
  • 86.98 (n)
(Rattus norvegicus)
Mammalia Cnnm3 34
  • 86.84 (n)
(Monodelphis domestica)
Mammalia CNNM3 35
  • 78 (a)
(Ornithorhynchus anatinus)
Mammalia CNNM3 35
  • 68 (a)
(Anolis carolinensis)
Reptilia CNNM3 35
  • 61 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cnnm3 34
  • 62.59 (n)
(Danio rerio)
Actinopterygii LOC100329721 34
  • 62.84 (n)
CABZ01071058.1 35
  • 49 (a)
fruit fly
(Drosophila melanogaster)
Insecta uex 35
  • 28 (a)
(Caenorhabditis elegans)
Secernentea C33D12.2 35
  • 23 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MAM3 35
  • 18 (a)
Species where no ortholog for CNNM3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CNNM3 Gene

Gene Tree for CNNM3 (if available)
Gene Tree for CNNM3 (if available)

Paralogs for CNNM3 Gene

Paralogs for CNNM3 Gene

(3) SIMAP similar genes for CNNM3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CNNM3: view

Variants for CNNM3 Gene

Sequence variations from dbSNP and Humsavar for CNNM3 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs10439526 -- 96,836,351(+) attct(A/C)ctgcc intron-variant
rs1047634 -- 96,832,920(+) TCCCC(C/T)GGGGC intron-variant, nc-transcript-variant, utr-variant-3-prime
rs1057296 -- 96,837,407(+) ATTTT(G/T)TTTTT downstream-variant-500B
rs10643982 -- 96,834,655(+) ACAGA(-/AG)AGTTT intron-variant, nc-transcript-variant, utr-variant-3-prime
rs10708500 -- 96,821,655(+) ATAAA(-/C)CCATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CNNM3 Gene

Variant ID Type Subtype PubMed ID
dgv607e201 CNV deletion 23290073
esv3425717 CNV duplication 20981092
esv5003 OTHER complex 18987735
nsv1072008 CNV deletion 25765185
nsv1112766 CNV deletion 24896259
nsv1135873 CNV deletion 24896259
nsv526313 CNV loss 19592680

Variation tolerance for CNNM3 Gene

Residual Variation Intolerance Score: 38.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.60; 30.77% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CNNM3 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CNNM3 Gene

Disorders for CNNM3 Gene

Relevant External Links for CNNM3

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CNNM3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CNNM3 Gene

Publications for CNNM3 Gene

  1. The protein tyrosine phosphatase PRL-2 interacts with the magnesium transporter CNNM3 to promote oncogenesis. (PMID: 24632616) Hardy S. … Tremblay M.L. (Oncogene 2015) 2 3 64
  2. Purification, crystallization and preliminary crystallographic analysis of the CBS pair of the human metal transporter CNNM4. (PMID: 21393841) GA^mez GarcA-a I. … MartA-nez-Cruz L.A. (Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 2011) 2 3 64
  3. Genome-wide association study to identify single nucleotide polymorphisms (SNPs) associated with the development of erectile dysfunction in African-American men after radiotherapy for prostate cancer. (PMID: 20932654) Kerns S.L. … Rosenstein B.S. (Int. J. Radiat. Oncol. Biol. Phys. 2010) 3 46 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. Molecular cloning and characterization of a novel gene family of four ancient conserved domain proteins (ACDP). (PMID: 12657465) Wang C.-Y. … She J.-X. (Gene 2003) 3 4 64

Products for CNNM3 Gene

Sources for CNNM3 Gene

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