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CNNM3 Gene

protein-coding   GIFtS: 50
GCID: GC02P097481

Cyclin M3


(Previous symbol: ACDP3)
  Search for CNNM3
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cyclin M31 2     cyclin-M32
ACDP31 2 3 5     Metal Transporter CNNM32
Ancient Conserved Domain-Containing Protein 32 3     Cyclin-M33
Ancient Conserved Domain Protein 32     

External Ids:    HGNC: 1041   Entrez Gene: 265052   Ensembl: ENSG000001687637   OMIM: 6078045   UniProtKB: Q8NE013   

Export aliases for CNNM3 gene to outside databases

Previous GC identifers: GC02P095354 GC02P095936 GC02P096949 GC02P096966 GC02P096903 GC02P096845 GC02P091442


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CNNM3 Gene:
CNNM3 (cyclin M3) is a protein-coding gene. GO annotations related to this gene include adenyl nucleotide binding. An important paralog of this gene is CNNM1.

UniProtKB/Swiss-Prot: CNNM3_HUMAN, Q8NE01
Function: Probable metal transporter (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the CNNM3 gene promoter:
         SRF   Pbx1a   SRF (504 AA)   NRSF form 1   NRSF form 2   CP2   HOXA5   Pax-4a   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for CNNM3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CNNM3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p12-p11.2   Ensembl cytogenetic band:  2q11.2   HGNC cytogenetic band: 2p12-p11.2

CNNM3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CNNM3 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P097481:  view genomic region     (about GC identifiers)

Start:
97,481,982 bp from pter      End:
97,501,121 bp from pter
Size:
19,140 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CNNM3_HUMAN, Q8NE01 (See protein sequence)
Recommended Name: Metal transporter CNNM3  
Size: 707 amino acids; 76119 Da
Miscellaneous: Shares weak sequence similarity with the cyclin family, hence its name. However, it has no
cyclin-like function in vivo
Sequence caution: Sequence=AAF86377.1; Type=Erroneous initiation; Sequence=AAH07199.3; Type=Erroneous initiation;
Sequence=BAA90891.1; Type=Frameshift; Positions=315;
Secondary accessions: B3KX67 Q8TBV4 Q96IW4 Q9NRK4 Q9NXW6
Alternative splicing: 3 isoforms:  Q8NE01-1   Q8NE01-2   Q8NE01-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CNNM3: NX_Q8NE01

Explore proteomics data for CNNM3 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys306, Lys462, Lys519, Lys526, Lys640
  • Glycosylation2 at Asn73
  • Modification sites at PhosphoSitePlus

  • See CNNM3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_060093.3  NP_951060.1  

    ENSEMBL proteins: 
     ENSP00000366260   ENSP00000305449  

    CNNM3 Human Recombinant Protein Products:

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    Novus Biologicals CNNM3 Protein
    Novus Biologicals CNNM3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CNNM3

     
    Search eBioscience for Proteins for CNNM3 

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    Abcam antibodies for CNNM3
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    LSBio Antibodies in human, mouse, rat for CNNM3

    CNNM3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CNNM3
    Cloud-Clone Corp. CLIAs for CNNM3
    Search eBioscience for ELISAs for CNNM3 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR000644 CBS_dom
     IPR002550 DUF21

    Graphical View of Domain Structure for InterPro Entry Q8NE01

    ProtoNet protein and cluster: Q8NE01

    2 Blocks protein domains:
    IPB000644 CBS domain
    IPB002550 CBS


    UniProtKB/Swiss-Prot: CNNM3_HUMAN, Q8NE01
    Similarity: Belongs to the ACDP family
    Similarity: Contains 2 CBS domains
    Similarity: Contains 1 DUF21 domain


    Find genes that share domains with CNNM3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CNNM3_HUMAN, Q8NE01
    Function: Probable metal transporter (By similarity)

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003899DNA-directed RNA polymerase activity ----
    GO:0005515protein binding IPI16189514
    GO:0030554adenyl nucleotide binding IEA--
         
    Find genes that share ontologies with CNNM3           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for CNNM3:
     Increased HPV18 LCR reporter a 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CNNM3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CNNM3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CNNM3
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    miRNA
    Products:
        
    miRTarBase miRNAs that target CNNM3:
    hsa-mir-155-5p (MIRT020730), hsa-mir-96-5p (MIRT027933), hsa-let-7b-5p (MIRT052005)

    Block miRNA regulation of human, mouse, rat CNNM3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CNNM3 (see all 48):
    hsa-miR-302d hsa-miR-520e hsa-miR-3194-5p hsa-miR-4254 hsa-miR-106a hsa-miR-877* hsa-miR-372 hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmidCNNM3 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CNNM3

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 2): CNNM3 (NM_017623)
    Sino Biological Human cDNA Clone for CNNM3
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CNNM3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CNNM3

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CNNM3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CNNM3_HUMAN, Q8NE01: Cell membrane; Multi-pass membrane protein (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytosol1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with CNNM3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CNNM3
    Interactions:

        Search GeneGlobe Interaction Network for CNNM3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    Selected Interacting proteins for CNNM3 (Q8NE011, 2, 3 ENSP000003054494) via UniProtKB, MINT, STRING, and/or I2D (see all 21)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RBPMSQ930622, 3, ENSP000003401764MINT-68099 I2D: score=5 STRING: ENSP00000340176
    MDFIQ997501, 2, 3, ENSP000002303214EBI-741032,EBI-724076 MINT-67938 I2D: score=5 STRING: ENSP00000230321
    KRTAP4-12Q9BQ662, 3, ENSP000003775824MINT-66811 I2D: score=5 STRING: ENSP00000377582
    PTP4A3O753653, ENSP000003322744I2D: score=2 STRING: ENSP00000332274
    RYKP349253, ENSP000002960844I2D: score=1 STRING: ENSP00000296084
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated ----
    GO:0006811ion transport IEA--

    Find genes that share ontologies with CNNM3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CNNM3



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CNNM3 gene (2 alternative transcripts): 
    NM_017623.4  NM_199078.2  

    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000377060(uc002swz.3) ENST00000305510(uc002swy.3) ENST00000465224
    ENST00000494595 ENST00000480035
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CNNM3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CNNM3 (see all 48):
    hsa-miR-302d hsa-miR-520e hsa-miR-3194-5p hsa-miR-4254 hsa-miR-106a hsa-miR-877* hsa-miR-372 hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmidCNNM3 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CNNM3
    Predesigned siRNA for gene silencing in human, mouse, rat CNNM3
    Clone
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    OriGene ORF clones in mouse, rat for CNNM3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CNNM3 (NM_017623)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CNNM3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CNNM3
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for CNNM3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CNNM3
      QuantiTect SYBR Green Assays in human, mouse, rat CNNM3
      QuantiFast Probe-based Assays in human, mouse, rat CNNM3

    Selected AceView cDNA sequences (see all 188):

    CA771086 AW779949 BQ226111 BM909589 BE219848 AK126847 AA193266 BI962783 
    CA436806 AI471327 AW083404 BM053131 AW300064 BM052819 BQ054671 CR749702 
    BQ059569 AA683316 BM823802 BQ643171 AW169713 AI383280 AA761693 AI873719 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for CNNM3    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8
    SP1:                                -                           
    SP2:              -                 -                           
    SP3:                                                            


    ECgene alternative splicing isoforms for CNNM3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CNNM3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AACCAGGTGG
    CNNM3 Expression
    About this image


    CNNM3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Mononuclear Myocytes Hyoid Arch Muscles
     
     Thymus (Hematopoietic System)
     
     Spleen (Hematopoietic System)
    CNNM3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CNNM3 Protein Expression

    UniProtKB/Swiss-Prot: CNNM3_HUMAN, Q8NE01
    Tissue specificity: Widely expressed. Expressed at higher level in heart and spleen

        Custom PCR Arrays for CNNM3
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CNNM3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for CNNM3 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cnnm31 , 5 cyclin M31, 5 86.98(n)1
    88.47(a)1
      1 (15.30 cM)5
    942181  NM_053186.21  NP_444416.21 
     365118675 
    lizard
    (Anolis carolinensis)
    Reptilia CNNM36
    cyclin M3
    61(a)
    1 ↔ 1
    GL343484.1(510126-528446)
    African clawed frog
    (Xenopus laevis)
    Amphibia BJ038331.12   -- 80.63(n)    BJ038331.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1003297211 metal transporter CNNM3-like 62.84(n)
    60.64(a)
      100329721  XM_003199481.2  XP_003199529.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta uex6
    unextended
    28(a)
    1 → many
    2RHet(3136909-3181390)
    worm
    (Caenorhabditis elegans)
    Secernentea C33D12.26
    Protein C33D12.2 (C33D12.2) mRNA, complete cds
    23(a)
    many ↔ many
    X(3041978-3045806) WBGene00016343
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes MAM36
    Protein required for normal mitochondrial morpholo...
    18(a)
    1 → many
    XV(214017-216137) YOL060C


    ENSEMBL Gene Tree for CNNM3 (if available)
    TreeFam Gene Tree for CNNM3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CNNM3 gene
    CNNM12  CNNM22  CNNM42  
    3 SIMAP similar genes for CNNM3 using alignment to 1 protein entry:     CNNM3_HUMAN:
    CNNM2    CNNM4    CNNM1

    Find genes that share paralogs with CNNM3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CNNM3 (see all 424)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1906072001,2
    --97482646(+) GGCGGG/TGCTGC 4 G V mis10--------
    rs2005177001,2
    C--97482906(+) GCGGCA/GGCGAC 4 S G mis10--------
    rs116870921,2
    C,A,H--97482908(+) GGCGGC/GGACCC 4 G syn1 ese30--------
    rs2001715071,2
    --97482926(+) GATCTC/GAGCAA 4 L syn10--------
    rs2020128901,2
    --97482967(+) CGTGCG/TCACGC 4 R L mis10--------
    rs1830356201,2
    C--97483057(+) CACGCA/GCATCC 4 H R mis10--------
    rs1511518161,2
    C,F--97483162(+) CATCAC/G/TTCGTT 6 T S I mis12NA EU 5857
    rs1445572841,2
    C,F--97483174(+) CTACAA/GCCATC 4 N S mis11Minor allele frequency- G:0.00NA 4534
    rs342287661,2
    C,F,H--97483211(-) GCGTCC/TAGCTT 4 L syn111Minor allele frequency- T:0.04NS NA CSA WA EU 6841
    rs2003676431,2
    C--97483430(+) CCATCG/TATCAG 2 -- int10--------

    HapMap Linkage Disequilibrium report for CNNM3 (97481982 - 97501121 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for CNNM3:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv650e201CNV Deletion23290073
    dgv4249n71CNV Loss21882294
    nsv874680CNV Loss21882294
    nsv526313CNV Loss19592680
    nsv874677CNV Loss21882294
    esv5003CNV Complex18987735

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CNNM3
    DNA2.0 Custom Variant and Variant Library Synthesis for CNNM3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607804    OMIM disorders: --


    Find genes that share disorders with CNNM3           About GenesLikeMe

    Genetic Association Database (GAD): CNNM3

    Export disorders for CNNM3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CNNM3 gene, integrated from 10 sources (see all 29):
    (articles sorted by number of sources associating them with CNNM3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genome-wide association study to identify single nucleotide polymorphisms (SNPs) associated with the development of erectile dysfunction in African-American men after radiotherapy for prostate cancer. (PubMed id 20932654)1, 4 Kerns S.L....Rosenstein B.S. (Int. J. Radiat. Oncol. Biol. Phys. 2010)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. Molecular cloning and characterization of a novel gene family of four ancient conserved domain proteins (ACDP). (PubMed id 12657465)1, 2 Wang C.-Y.... She J.-X. (Gene 2003)
    4. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    5. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    6. Novel, gel-free proteomics approach identifies RNF5 and JAMP as modulators of GPCR stability. (PubMed id 23798571)1 Roy S.J....Parent J.L. (Mol. Endocrinol. 2013)
    7. Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)1 Oshikawa K....Nakayama K.I. (J. Proteome Res. 2012)
    8. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    9. Proteomic identification of common SCF ubiquitin ligase FBXO6-interacting glycoproteins in three kinds of cells. (PubMed id 22268729)1 Liu B....Wang L.S. (J. Proteome Res. 2012)
    10. Mapping a dynamic innate immunity protein interaction network regulating type I interferon production. (PubMed id 21903422)1 Li S.... Dorf M.E. (Immunity 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 26505 HGNC: 104 AceView: CNNM3 Ensembl:ENSG00000168763 euGenes: HUgn26505
    ECgene: CNNM3 H-InvDB: CNNM3

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CNNM3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CNNM3 gene:
    Search GeneIP for patents involving CNNM3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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