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Aliases for CNNM3 Gene

Aliases for CNNM3 Gene

  • Cyclin And CBS Domain Divalent Metal Cation Transport Mediator 3 2 3
  • ACDP3 3 4 6
  • Ancient Conserved Domain-Containing Protein 3 3 4
  • Cyclin M3 2 3
  • Cyclin-M3 3 4
  • Ancient Conserved Domain Protein 3 3
  • Metal Transporter CNNM3 3

External Ids for CNNM3 Gene

Previous Symbols for CNNM3 Gene

  • ACDP3

Summaries for CNNM3 Gene

GeneCards Summary for CNNM3 Gene

CNNM3 (Cyclin And CBS Domain Divalent Metal Cation Transport Mediator 3) is a Protein Coding gene. GO annotations related to this gene include adenyl nucleotide binding. An important paralog of this gene is CNNM2.

UniProtKB/Swiss-Prot for CNNM3 Gene

  • Probable metal transporter.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CNNM3 Gene

Genomics for CNNM3 Gene

Genomic Location for CNNM3 Gene

Start:
96,815,214 bp from pter
End:
96,835,384 bp from pter
Size:
20,171 bases
Orientation:
Plus strand

Genomic View for CNNM3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CNNM3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CNNM3 Gene

Regulatory Elements for CNNM3 Gene

Proteins for CNNM3 Gene

  • Protein details for CNNM3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NE01-CNNM3_HUMAN
    Recommended name:
    Metal transporter CNNM3
    Protein Accession:
    Q8NE01
    Secondary Accessions:
    • B3KX67
    • Q8TBV4
    • Q96IW4
    • Q9NRK4
    • Q9NXW6

    Protein attributes for CNNM3 Gene

    Size:
    707 amino acids
    Molecular mass:
    76119 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Shares weak sequence similarity with the cyclin family, hence its name. However, it has no cyclin-like function in vivo
    SequenceCaution:
    • Sequence=AAF86377.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH07199.3; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA90891.1; Type=Frameshift; Positions=315; Evidence={ECO:0000305};

    Alternative splice isoforms for CNNM3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CNNM3 Gene

Proteomics data for CNNM3 Gene at MOPED

Post-translational modifications for CNNM3 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys306, Lys462, Lys519, Lys526, and Lys640
  • Glycosylation at Asn73

Other Protein References for CNNM3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CNNM3 Gene

Domains for CNNM3 Gene

Protein Domains for CNNM3 Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

CNNM3_HUMAN
Domain:
  • Contains 2 CBS domains.:
    • Q8NE01
  • Contains 1 DUF21 domain.:
    • Q8NE01
Family:
  • Belongs to the ACDP family.:
    • Q8NE01
genes like me logo Genes that share domains with CNNM3: view

No data available for Gene Families for CNNM3 Gene

Function for CNNM3 Gene

Molecular function for CNNM3 Gene

UniProtKB/Swiss-Prot Function: Probable metal transporter.

Gene Ontology (GO) - Molecular Function for CNNM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding --
GO:0003899 DNA-directed RNA polymerase activity --
GO:0005515 protein binding IPI 16189514
GO:0030554 adenyl nucleotide binding --
genes like me logo Genes that share ontologies with CNNM3: view

Phenotypes for CNNM3 Gene

GenomeRNAi human phenotypes for CNNM3:
genes like me logo Genes that share phenotypes with CNNM3: view

miRNA for CNNM3 Gene

miRTarBase miRNAs that target CNNM3

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for CNNM3 Gene

Localization for CNNM3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CNNM3 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CNNM3 Gene COMPARTMENTS Subcellular localization image for CNNM3 gene
Compartment Confidence
plasma membrane 5
cytosol 1

Gene Ontology (GO) - Cellular Components for CNNM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IDA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CNNM3: view

Pathways for CNNM3 Gene

SuperPathways for CNNM3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CNNM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated --
GO:0006811 ion transport IEA --
genes like me logo Genes that share ontologies with CNNM3: view

No data available for Pathways by source for CNNM3 Gene

Transcripts for CNNM3 Gene

Unigene Clusters for CNNM3 Gene

Cyclin M3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CNNM3 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8
SP1: -
SP2: - -
SP3:

Relevant External Links for CNNM3 Gene

GeneLoc Exon Structure for
CNNM3
ECgene alternative splicing isoforms for
CNNM3

Expression for CNNM3 Gene

mRNA expression in normal human tissues for CNNM3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CNNM3 Gene

SOURCE GeneReport for Unigene cluster for CNNM3 Gene Hs.711617

mRNA Expression by UniProt/SwissProt for CNNM3 Gene

Q8NE01-CNNM3_HUMAN
Tissue specificity: Widely expressed. Expressed at higher level in heart and spleen.
genes like me logo Genes that share expressions with CNNM3: view

Orthologs for CNNM3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CNNM3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CNNM3 36
  • 99.53 (n)
  • 99.58 (a)
CNNM3 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CNNM3 36
  • 89.39 (n)
  • 91.48 (a)
CNNM3 37
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CNNM3 36
  • 90.23 (n)
  • 92.31 (a)
CNNM3 37
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cnnm3 36
  • 86.98 (n)
  • 88.47 (a)
Cnnm3 16
Cnnm3 37
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CNNM3 37
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CNNM3 37
  • 68 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cnnm3 36
  • 86.84 (n)
  • 89.19 (a)
lizard
(Anolis carolinensis)
Reptilia CNNM3 37
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cnnm3 36
  • 62.59 (n)
  • 61.28 (a)
zebrafish
(Danio rerio)
Actinopterygii CABZ01071058.1 37
  • 49 (a)
OneToOne
LOC100329721 36
  • 62.84 (n)
  • 60.64 (a)
fruit fly
(Drosophila melanogaster)
Insecta uex 37
  • 28 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C33D12.2 37
  • 23 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MAM3 37
  • 18 (a)
OneToMany
Species with no ortholog for CNNM3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CNNM3 Gene

ENSEMBL:
Gene Tree for CNNM3 (if available)
TreeFam:
Gene Tree for CNNM3 (if available)

Paralogs for CNNM3 Gene

Paralogs for CNNM3 Gene

Selected SIMAP similar genes for CNNM3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CNNM3: view

Variants for CNNM3 Gene

Sequence variations from dbSNP and Humsavar for CNNM3 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs9948 -- 96,835,063(-) ttatc(C/G/T)tgatt utr-variant-3-prime
rs12172 -- 96,835,115(-) ACCAG(C/G)AGTTA utr-variant-3-prime
rs938850 -- 96,822,499(-) gaccc(C/T)aatct intron-variant
rs1047634 -- 96,832,920(+) TCCCC(C/T)GGGGC utr-variant-3-prime, reference, missense, downstream-variant-500B
rs1317911 -- 96,822,961(-) CTCCA(A/C)GGAGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CNNM3 Gene

Variant ID Type Subtype PubMed ID
dgv650e201 CNV Deletion 23290073
esv5003 CNV Complex 18987735
nsv874677 CNV Loss 21882294
nsv874680 CNV Loss 21882294
nsv526313 CNV Loss 19592680
dgv4249n71 CNV Loss 21882294

Relevant External Links for CNNM3 Gene

HapMap Linkage Disequilibrium report
CNNM3
Human Gene Mutation Database (HGMD)
CNNM3

Disorders for CNNM3 Gene

Relevant External Links for CNNM3

Genetic Association Database (GAD)
CNNM3
genes like me logo Genes that share disorders with CNNM3: view

No data available for UniProtKB/Swiss-Prot for CNNM3 Gene

Publications for CNNM3 Gene

  1. Molecular cloning and characterization of a novel gene family of four ancient conserved domain proteins (ACDP). (PMID: 12657465) Wang C.-Y. … She J.-X. (Gene 2003) 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Genome-wide association study to identify single nucleotide polymorphisms (SNPs) associated with the development of erectile dysfunction in African-American men after radiotherapy for prostate cancer. (PMID: 20932654) Kerns S.L. … Rosenstein B.S. (Int. J. Radiat. Oncol. Biol. Phys. 2010) 3 49
  4. Purification, crystallization and preliminary crystallographic analysis of the CBS pair of the human metal transporter CNNM4. (PMID: 21393841) GA^mez GarcA-a I. … MartA-nez-Cruz L.A. (Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 2011) 2 3
  5. The protein tyrosine phosphatase PRL-2 interacts with the magnesium transporter CNNM3 to promote oncogenesis. (PMID: 24632616) Hardy S. … Tremblay M.L. (Oncogene 2015) 2 3

Products for CNNM3 Gene

Sources for CNNM3 Gene

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