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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CNNM3 Gene

protein-coding   GIFtS: 48
GCID: GC02P097481

cyclin M3


(Previous symbol: ACDP3)
 Explore 8 diseases affiliated with
CNNM3 via our new
 Human Malady Compendium 
Biological research products
for CNNM3
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Cyclin M31 2     Cyclin-M33
ACDP31 2 3 5     Metal Transporter CNNM32
Ancient Conserved Domain-Containing Protein 32 3     Cyclin-M33
Ancient Conserved Domain Protein 32     

External Ids:    HGNC: 1041   Entrez Gene: 265052   Ensembl: ENSG000001687637   OMIM: 6078045   UniProtKB: Q8NE013   

Export aliases for CNNM3 gene to outside databases

Previous GC identifers: GC02P095354 GC02P095936 GC02P096949 GC02P096966 GC02P096903 GC02P096845 GC02P091442


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: CNNM3_HUMAN, Q8NE01
Function: Probable metal transporter (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.1  NT_022171.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CNNM3 gene promoter:
         SRF   Pbx1a   SRF (504 AA)   NRSF form 1   NRSF form 2   CP2   HOXA5   Pax-4a   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for CNNM3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CNNM3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p12-p11.2   Ensembl cytogenetic band:  2q11.2   HGNC cytogenetic band: 2p12-p11.2

CNNM3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CNNM3 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P097481:  view genomic region     (about GC identifiers)

Start:
97,481,982 bp from pter      End:
97,501,121 bp from pter
Size:
19,140 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CNNM3_HUMAN, Q8NE01 (See protein sequence)
Recommended Name: Metal transporter CNNM3  
Size: 707 amino acids; 76119 Da
Subcellular location: Cell membrane; Multi-pass membrane protein (By similarity)
Miscellaneous: Shares weak sequence similarity with the cyclin family, hence its name. However, it has no cyclin-like
function in vivo
Sequence caution: Sequence=AAF86377.1; Type=Erroneous initiation; Sequence=AAH07199.3; Type=Erroneous initiation;
Sequence=BAA90891.1; Type=Frameshift; Positions=315;
Secondary accessions: B3KX67 Q8TBV4 Q96IW4 Q9NRK4 Q9NXW6
Alternative splicing: 3 isoforms:  Q8NE01-1   Q8NE01-2   Q8NE01-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CNNM3: NX_Q8NE01

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8NE01

  • CNNM3 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_060093.3  NP_951060.1  

    ENSEMBL proteins: 
     ENSP00000366260   ENSP00000305449  

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    Uscn Proteins for CNNM3

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0016021integral to membrane IEA--


    CNNM3 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    CNNM3 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR000644 Cysta_beta_synth_core
     IPR002550 DUF21

    Graphical View of Domain Structure for InterPro Entry Q8NE01

    ProtoNet protein and cluster: Q8NE01

    2 Blocks protein families:
    IPB000644 CBS domain
    IPB002550 CBS


    UniProtKB/Swiss-Prot: CNNM3_HUMAN, Q8NE01
    Similarity: Belongs to the ACDP family
    Similarity: Contains 2 CBS domains
    Similarity: Contains 1 DUF21 domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: CNNM3_HUMAN, Q8NE01
    Function: Probable metal transporter (By similarity)

    miRNA
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    hsa-miR-302d hsa-miR-520e hsa-miR-3194-5p hsa-miR-4254 hsa-miR-106a hsa-miR-877* hsa-miR-372 hsa-miR-93
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    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI19060904


    CNNM3 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for CNNM3:
     Increased HPV18 LCR reporter a 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CNNM3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

    5/20 Interacting proteins for CNNM3 (Q8NE011, 2, 3 ENSP000003054494) via UniProtKB, MINT, STRING, and/or I2D (see all 20)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RBPMSQ930622, 3, ENSP000003401764MINT-68099 I2D: score=5 STRING: ENSP00000340176
    MDFIQ997501, 2, 3, ENSP000002303214EBI-741032,EBI-724076 MINT-67938 I2D: score=5 STRING: ENSP00000230321
    KRTAP4-12Q9BQ662, 3, ENSP000003775824MINT-66811 I2D: score=5 STRING: ENSP00000377582
    PTP4A3O753653, ENSP000003322744I2D: score=2 STRING: ENSP00000332274
    RYKP349253, ENSP000002960844I2D: score=1 STRING: ENSP00000296084
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006811ion transport IEA--


    CNNM3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CNNM3
    Search CenterWatch for drugs/clinical trials and news about CNNM3 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CNNM3 gene (2 alternative transcripts): 
    NM_017623.4  NM_199078.2  

    Unigene Cluster for CNNM3:

    Cyclin M3
    Hs.711617  [show with all ESTs]
    Unigene Representative Sequence: NM_017623
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000377060(uc002swz.3) ENST00000305510(uc002swy.3) ENST00000465224
    ENST00000494595 ENST00000480035

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    8/48 QIAGEN miScript miRNA Assays for microRNAs that regulate CNNM3 (see all 48):
    hsa-miR-302d hsa-miR-520e hsa-miR-3194-5p hsa-miR-4254 hsa-miR-106a hsa-miR-877* hsa-miR-372 hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmidCNNM3 3' UTR sequence
    Inhib. RNA
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    Clone
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    Additional cDNA sequence: 

    AF216965.1 AK000025.1 AK126847.1 BC007199.1 BC018604.1 BC022944.1 BC037272.1 

    13 DOTS entries:

    DT.95085337  DT.100682173  DT.100026231  DT.95262564  DT.100773988  DT.95290912  DT.40112444  DT.120995910 
    DT.99968592  DT.315363  DT.86845565  DT.100674040  DT.120995907 

    24/188 AceView cDNA sequences (see all 188):

    BQ059569 BM909589 AF216965 AI873719 AA864580 BE502265 BM703846 BM509667 
    BC022944 CA771086 BQ070671 AA987274 BQ286674 NM_199078 BI438732 BI439061 
    AI383280 BC018604 AI278213 BM053131 AA314076 AI248206 BE739853 AA761693 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for CNNM3    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8
    SP1:                                -                           
    SP2:              -                 -                           
    SP3:                                                            


    ECgene alternative splicing isoforms for CNNM3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CNNM3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AACCAGGTGG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See CNNM3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CNNM3

    SOURCE GeneReport for Unigene cluster: Hs.711617

    UniProtKB/Swiss-Prot: CNNM3_HUMAN, Q8NE01
    Tissue specificity: Widely expressed. Expressed at higher level in heart and spleen

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CNNM3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CNNM3 gene from 7/25 species (see all 25)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    lizard
    (Anolis carolinensis)
    Reptilia CNNM36
    --
    60(a)
    1 ↔ 1
    GL343484.1(510126-528446)
    African clawed frog
    (Xenopus laevis)
    Amphibia BJ038331.12   -- 80.63(n)    BJ038331.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1003297211 metal transporter CNNM3-like 59.93(n)
    55.68(a)
      100329721  XM_003199481.1  XP_003199529.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta uex6
    unextended
    27(a)
    1 → many
    2RHet(3136909-3181390)
    worm
    (Caenorhabditis elegans)
    Secernentea C33D12.26
    C52D10.126
    (see all 5)
    --
    22(a)
    21(a)
    (see all 5)
    many ↔ many
    many ↔ many
    (see all 5)
    X(3041968-3045796)
    IV(17197872-17206809)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G032706
    AT4G142406
    (see all 7)
    CBS and DUF21 domain-containing protein
    (see all 7)
    22(a)
    22(a)
    (see all 7)
    possible ortholog
    possible ortholog
    (see all 7)
    1(799191-802436)
    4(8204347-8207408)
    rice
    (Oryza sativa)
    Liliopsida --
    --
    (see all 3)
    CBS domain containing protein, expressed
    (see all 3)
    22(a)
    22(a)
    (see all 3)
    possible ortholog
    possible ortholog
    (see all 3)
    5(19170330-19177914)
    3(26644652-26650901)


    ENSEMBL Gene Tree for CNNM3 (if available)
    TreeFam Gene Tree for CNNM3 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CNNM3 gene
    CNNM12  CNNM22  CNNM42  
    3 SIMAP similar genes for CNNM3 using alignment to 1 protein entry:     CNNM3_HUMAN:
    CNNM2    CNNM4    CNNM1

    CNNM3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/353 NCBI SNPs in CNNM3 are shown (see all 353    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs559614301,2
    --91440425(+) GTCTCC/GATCTT 3 -- nc-transcript-variantus2k10--------
    rs1116773741,2
    C,F--91440482(+) CAGGCG/ATGAGC 1 -- nc-transcript-variant2Minor allele frequency- A:0.50NA 4
    rs1415890961,2
    --97480000(+) GTGATC/GTGCCC 3 -- nc-transcript-variantus2k10--------
    rs1890064421,2
    --97480001(+) TGATGC/TGCCCG 3 -- us2k1 nc-transcript-variant0--------
    rs1809082861,2
    --97480046(+) GAGCCA/GCCGCG 3 -- us2k1 nc-transcript-variant0--------
    rs1458785901,2
    --97480103(+) CTGTCA/GCCCAG 3 -- nc-transcript-variantus2k10--------
    rs1871715361,2
    --97480211(+) GGTGCA/CCGCCA 3 -- us2k10--------
    rs1907859421,2
    --97480491(+) AACCCC/TGTCTC 3 -- us2k10--------
    rs1814774771,2
    --97480583(+) ATGGCG/TTGAAC 3 -- us2k10--------
    rs113209531,2
    C--97480730(+) ACTCA-/TTTTTT 3 -- us2k1 tfbs3 trp30--------

    HapMap Linkage Disequilibrium report for CNNM3 (97481982 - 97501121 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for CNNM3: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CNNM3
    DNA2.0 Custom Variant and Variant Library Synthesis for CNNM3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    CNNM3 for disorders           About GeneDecksing

    OMIM gene information: 607804    OMIM disorders: --

    8 diseases for CNNM3:    About MalaCards
    prostate cancer    breast cancer    pneumonia    prostatitis
    tuberculosis    malaria    neuronitis    mycobacterium tuberculosis


    Export disorders for CNNM3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CNNM3 gene, integrated from 9 sources (see all 20):
    (articles sorted by number of sources associating them with CNNM3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    2. Molecular cloning and characterization of a novel gene family of four ancient conserved domain proteins (ACDP). (PubMed id 12657465)1, 2 Wang C.-Y.... She J.-X. (2003)
    3. Mapping a dynamic innate immunity protein interaction network regulating type I interferon production. (PubMed id 21903422)1 Li S....Dorf M.E. (2011)
    4. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    5. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    6. Mindbomb 1, an E3 ubiquitin ligase, forms a complex w ith RYK to activate Wnt/I^-catenin signaling. (PubMed id 21875946)1 Berndt J.D....Moon R.T. (2011)
    7. Ubiquitin ligase substrate identification through qua ntitative proteomics at both the protein and peptide levels. (PubMed id 21987572)1 Lee K.A....Doedens J.R. (2011)
    8. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    9. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
    10. Genome-wide association study to identify single nucl eotide polymorphisms (SNPs) associated with the development of erectile dysfunc tion in African-American men after radiotherapy for prostate cancer. (PubMed id 20932654)1 Kerns S.L....Rosenstein B.S. (2010)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 26505 HGNC: 104 AceView: CNNM3 Ensembl:ENSG00000168763 euGenes: HUgn26505
    ECgene: CNNM3 H-InvDB: CNNM3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CNNM3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CNNM3 gene:
    Search GeneIP for patents involving CNNM3

    GeneCards and IP:
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