Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CNNM2 Gene

protein-coding   GIFtS: 55
GCID: GC10P104668

Cyclin M2


(Previous symbol: ACDP2)
Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Cyclin M21 2
ACDP21 2 3 5
Ancient Conserved Domain-Containing Protein 22 3
Metal Transporter CNNM22
Cyclin-M23

External Ids:    HGNC: 1031   Entrez Gene: 548052   Ensembl: ENSG000001488427   OMIM: 6078035   UniProtKB: Q9H8M53   

Export aliases for CNNM2 gene to outside databases

Previous GC identifers: GC10P103571 GC10P103911 GC10P104809 GC10P104342 GC10P098313


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CNNM2 Gene:
This gene encodes a member of the ancient conserved domain containing protein family. Members of this protein
family contain a cyclin box motif and have structural similarity to the cyclins. The encoded protein may play an
important role in magnesium homeostasis by mediating the epithelial transport and renal reabsorption of Mg2+.
Mutations in this gene are associated with renal hypomagnesemia. Alternatively spliced transcript variants
encoding multiple isoforms have been observed for this gene. (provided by RefSeq, Dec 2011)

GeneCards Summary for CNNM2 Gene: 
CNNM2 (cyclin M2) is a protein-coding gene. Diseases associated with CNNM2 include hypomagnesemia 6, renal, and amelogenesis imperfecta. An important paralog of this gene is CNNM1.

UniProtKB/Swiss-Prot: CNNM2_HUMAN, Q9H8M5
Function: Divalent metal cation transporter. Mediates transport of divalent metal cations in an order of Mg(2+) >
Co(2+) > Mn(2+) > Sr(2+) > Ba(2+) > Cu(2+) > Fe(2+) (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NT_030059.13  NC_018921.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CNNM2 gene promoter:
         AhR   p53   Sp1   CUTL1   YY1   PPAR-alpha   CREB   SEF-1 (1)   Hlf   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCNNM2 promoter sequence
   Search SABiosciences Chromatin IP Primers for CNNM2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CNNM2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q24.32   Ensembl cytogenetic band:  10q24.32   HGNC cytogenetic band: 10q23-q24

CNNM2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CNNM2 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P104668:  view genomic region     (about GC identifiers)

Start:
104,678,074 bp from pter      End:
104,838,344 bp from pter
Size:
160,271 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CNNM2_HUMAN, Q9H8M5 (See protein sequence)
Recommended Name: Metal transporter CNNM2  
Size: 875 amino acids; 96623 Da
Subcellular location: Cell membrane; Multi-pass membrane protein (By similarity)
Miscellaneous: Shares weak sequence similarity with the cyclin family, hence its name. However, it has no
cyclin-like function in vivo
Sequence caution: Sequence=AAF86374.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=BAA90926.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAB14386.1;
Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=CAI16511.1; Type=Erroneous gene model
prediction; Sequence=CAI16512.1; Type=Erroneous gene model prediction; Sequence=CAI40076.1; Type=Erroneous gene
model prediction; Sequence=CAI40077.1; Type=Erroneous gene model prediction;
Secondary accessions: Q5T569 Q5T570 Q8WU59 Q9H952 Q9NRK5 Q9NXT4
Alternative splicing: 3 isoforms:  Q9H8M5-1   Q9H8M5-2   Q9H8M5-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CNNM2: NX_Q9H8M5

Explore proteomics data for CNNM2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9H8M5

  • CNNM2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CNNM2 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_060119.3  NP_951058.1  NP_951059.1  

    ENSEMBL proteins: 
     ENSP00000358891   ENSP00000392875   ENSP00000402831   ENSP00000358894  

    Human Recombinant Protein Products for CNNM2: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for CNNM2
    GenScript Custom Purified and Recombinant Proteins Services for CNNM2
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CNNM2 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral to membrane IEA--
    GO:0016323basolateral plasma membrane IMP--

    CNNM2 for ontologies           About GeneDecksing



    CNNM2 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for CNNM2
    GenScript Custom Superior Antibodies Services for CNNM2
    Novus Biologicals CNNM2 Antibody
    Abcam antibodies for CNNM2
    Cloud-Clone Corp. Antibodies for CNNM2 
    Search ThermoFisher Antibodies for CNNM2
    LSBio Antibodies in human, mouse, rat for CNNM2 

    Assay Products for CNNM2: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CNNM2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CNNM2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CNNM2 
    Cloud-Clone Corp. CLIAs for CNNM2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR000644 Cysta_beta_synth_core
     IPR002550 DUF21
     IPR014710 RmlC-like_jellyroll

    Graphical View of Domain Structure for InterPro Entry Q9H8M5

    ProtoNet protein and cluster: Q9H8M5

    2 Blocks protein domains:
    IPB000644 CBS domain
    IPB002550 CBS


    UniProtKB/Swiss-Prot: CNNM2_HUMAN, Q9H8M5
    Similarity: Belongs to the ACDP family
    Similarity: Contains 2 CBS domains
    Similarity: Contains 1 DUF21 domain


    CNNM2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CNNM2_HUMAN, Q9H8M5
    Function: Divalent metal cation transporter. Mediates transport of divalent metal cations in an order of Mg(2+) >
    Co(2+) > Mn(2+) > Sr(2+) > Ba(2+) > Cu(2+) > Fe(2+) (By similarity)

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0030554adenyl nucleotide binding IEA--
         
    CNNM2 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for CNNM2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CNNM2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CNNM2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CNNM2 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CNNM2
    8/45 QIAGEN miScript miRNA Assays for microRNAs that regulate CNNM2 (see all 45):
    hsa-miR-579 hsa-miR-15a hsa-miR-503 hsa-let-7a-2* hsa-miR-138-2* hsa-miR-342-3p hsa-miR-424 hsa-miR-9
    SwitchGear 3'UTR luciferase reporter plasmidCNNM2 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CNNM2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CNNM2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CNNM2
    Sirion Biotech Customized adenovirus for overexpression of CNNM2

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for CNNM2 (see all 17)
    OriGene ORF clones in mouse, rat for CNNM2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): CNNM2 (NM_199077)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CNNM2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CNNM2
    Sirion Biotech Customized lentivirus for stable overexpression of CNNM2 
                         Customized lentivirus expression plasmids for stable overexpression of CNNM2 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CNNM2
    Search LifeMap BioReagents cell lines for CNNM2
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CNNM2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CNNM2

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    3 Interacting proteins for CNNM2 (Q9H8M53 ENSP000003588944) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RYKP349253, ENSP000002960844I2D: score=1 STRING: ENSP00000296084
    TRAPPC3O436173I2D: score=1 
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0010960magnesium ion homeostasis IMP--
    GO:0015693magnesium ion transport IEA--

    CNNM2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CNNM2

    Search CenterWatch for drugs/clinical trials and news about CNNM2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CNNM2 gene (3 alternative transcripts): 
    NM_017649.4  NM_199076.2  NM_199077.2  

    Unigene Cluster for CNNM2:

    Cyclin M2
    Hs.643509  [show with all ESTs]
    Unigene Representative Sequence: NM_017649
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000369875(uc001kwl.3) ENST00000433628 ENST00000457502(uc001kwm.3 uc001kwn.3)
    ENST00000475511 ENST00000369878

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CNNM2
    8/45 QIAGEN miScript miRNA Assays for microRNAs that regulate CNNM2 (see all 45):
    hsa-miR-579 hsa-miR-15a hsa-miR-503 hsa-let-7a-2* hsa-miR-138-2* hsa-miR-342-3p hsa-miR-424 hsa-miR-9
    SwitchGear 3'UTR luciferase reporter plasmidCNNM2 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CNNM2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CNNM2
    Clone
    Products:
         
    OriGene clones in human, mouse for CNNM2 (see all 17)
    OriGene ORF clones in mouse, rat for CNNM2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): CNNM2 (NM_199077)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CNNM2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CNNM2
    Sirion Biotech Customized lentivirus for stable overexpression of CNNM2 
                         Customized lentivirus expression plasmids for stable overexpression of CNNM2 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for CNNM2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CNNM2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CNNM2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CNNM2

    Additional mRNA sequence: 

    AF216962.1 AK000071.1 AK023066.1 AK023479.1 BC021222.2 

    6 DOTS entries:

    DT.95157342  DT.412460  DT.438085  DT.306632  DT.95157340  DT.99999302 

    24/103 AceView cDNA sequences (see all 103):

    AW452585 BM562876 AI827730 AK023066 AW469552 NM_017649 NM_199077 BM711859 
    AI499732 F04472 NM_199076 BU675201 CF890717 CA435665 AK023479 AW611666 
    Z41609 CF886849 AA430042 AK090785 AF216962 BU632128 BM727814 BC021222 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for CNNM2    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b
    SP1:              -                       -                                       
    SP2:              -                       -           -                           
    SP3:                                                  -                           
    SP4:                                                                              


    ECgene alternative splicing isoforms for CNNM2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CNNM2 expression in normal human tissues (normalized intensities)      CNNM2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGGCCCGGCA
    CNNM2 Expression
    About this image


    CNNM2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/6 selected tissues (see all 6) fully expand
     
     Colon (Gastrointestinal Tract)    fully expand to see all 3 entries
             sigmoid colon mucosa   
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Thalamus
             Midbrain   
     
     Intestine (Gastrointestinal Tract)
             SMALL INTESTINE   
     
     Ovary (Reproductive System)
             oocyte   
     
     Adipose (Muscoskeletal System)
             epididymal fat pads   

    See CNNM2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CNNM2

    SOURCE GeneReport for Unigene cluster: Hs.643509

    UniProtKB/Swiss-Prot: CNNM2_HUMAN, Q9H8M5
    Tissue specificity: Widely expressed. Expressed at higher level in brain, kidney and placenta, while it is weakly
    expressed in skeletal muscle. In the kidney, it is expressed in the distal convoluted tubule and the thick
    ascending limb of Henle loop

        SABiosciences Custom PCR Arrays for CNNM2
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for CNNM2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CNNM2
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CNNM2
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CNNM2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CNNM2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CNNM2 gene from 10/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cnnm21 , 5 cyclin M21, 5 91.66(n)1
    97.83(a)1
      19 (38.97 cM)5
    942191  NM_033569.31  NP_291047.21 
     467616095 
    chicken
    (Gallus gallus)
    Aves CNNM21 cyclin M2 87.66(n)
    96.01(a)
      428975  XM_426532.3  XP_426532.3 
    lizard
    (Anolis carolinensis)
    Reptilia CNNM26
    Uncharacterized protein
    84(a)
    1 ↔ 1
    3(40338500-40470126)
    African clawed frog
    (Xenopus laevis)
    Amphibia BJ066530.12   -- 81.65(n)    BJ066530.1 
    zebrafish
    (Danio rerio)
    Actinopterygii cnnm2a6
    CNNM2 (1 of 2)6
    cyclin M2
    80(a)
    80(a)
    many → 1
    many → 1
    13(28841688-28866862)
    1(31179273-31253329)
    fruit fly
    (Drosophila melanogaster)
    Insecta uex6
    unextended
    40(a)
    1 → many
    2RHet(3136909-3181390)
    worm
    (Caenorhabditis elegans)
    Secernentea C33D12.23   -- 44(a)
    (best of 3)
      X(3077278-3081092)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes MAM36
    Protein required for normal mitochondrial morpholo...
    23(a)
    1 → many
    XV(214017-216137)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT4G142401 CBS and DUF21 domain-containing protein 48.08(n)
    38.94(a)
      827065  NM_117501.4  NP_193160.3 
    rice
    (Oryza sativa)
    Liliopsida Os05g03953001 hypothetical protein 48.31(n)
    40.11(a)
      4338701  NM_001061997.1  NP_001055462.1 


    ENSEMBL Gene Tree for CNNM2 (if available)
    TreeFam Gene Tree for CNNM2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CNNM2 gene
    CNNM12  CNNM32  CNNM42  
    4 SIMAP similar genes for CNNM2 using alignment to 1 protein entry:     CNNM2_HUMAN:
    DKFZp434I1016    CNNM1    CNNM4    CNNM3

    CNNM2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3051 SNPs in CNNM2 are shown (see all 3051)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0652604
    Hypomagnesemia 6 (HOMG6)4--see VAR_0652602 T I mis40--------
    rs1819070661,2
    C--98317068(+) AAAAAA/GAAACA 3 -- int10--------
    rs340632911,2
    C--98328120(+) TTTTTT/-GGAGA 2 -- int11Minor allele frequency- -:0.50CSA 2
    rs1435681821,2
    C--98332606(+) AAAAA-/GACAACGC 2 -- int10--------
    rs111914691,2
    A--98333970(+) AACAAC/AAAAAA 2 -- int1 trp32Minor allele frequency- A:0.25NA CSA 4
    rs1408910821,2
    C--98342869(+) ATGAT-/ACTG  
            
    TAGAG
    2 -- int10--------
    rs1115954781,2
    C--98355943(+) CAAAC-/TTATGAC 2 -- int11Minor allele frequency- TT:0.00CSA 2
    rs1414815031,2
    C--98362092(+) TAAGA-/ATATATA 2 -- int10--------
    rs57874781,2
    C,F--98367789(+) GTATT-/CCCCCC 2 -- int1 trp33Minor allele frequency- C:0.33NA CSA 6
    rs2008771011,2
    C--98367789(+) GTATTC/TCCCCC 2 -- int10--------

    HapMap Linkage Disequilibrium report for CNNM2 (104678074 - 104838344 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CNNM2:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2449517CNV Insertion19546169
    nsv7528CNV Loss18451855


    Human Gene Mutation Database (HGMD): CNNM2
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CNNM2
    DNA2.0 Custom Variant and Variant Library Synthesis for CNNM2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 607803    OMIM disorders: --

    UniProtKB/Swiss-Prot: CNNM2_HUMAN, Q9H8M5
  • Hypomagnesemia 6 (HOMG6) [MIM:613882]: A renal disease characterized by severely lowered serum magnesium
    levels in the absence of other electrolyte disturbances. Affected individuals show an inappropriately normal
    urinary magnesium excretion, demonstrating a defect in tubular reabsorption. Age of clinical onset is highly
    variable and some affected individuals are asymptomatic. Note=The disease is caused by mutations affecting the
    gene represented in this entry

  • 9 diseases for CNNM2:    About MalaCards
    hypomagnesemia 6, renal    amelogenesis imperfecta    cone-rod dystrophy    gigantism
    parkinson's disease    hypertension    neuroblastoma    tuberculosis
    alzheimer's disease


    CNNM2 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): CNNM2
    Human Genome Epidemiology (HuGE) Navigator: CNNM2 (5 documents)

    Export disorders for CNNM2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CNNM2 gene, integrated from 9 sources (see all 28):
    (articles sorted by number of sources associating them with CNNM2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genome-wide association study identifies five new schi zophrenia loci. (PubMed id 21926974)1, 4 (2011)
    2. Large-scale association analysis identifies 13 new su sceptibility loci for coronary artery disease. (PubMed id 21378990)1, 4 Schunkert H....Samani N.J. (2011)
    3. A genome-wide association study in Europeans and Sout h Asians identifies five new loci for coronary artery disease. (PubMed id 21378988)1, 4 (2011)
    4. CNNM2, encoding a basolateral protein required for renal Mg2+ handling, is mutated in dominant hypomagnesemia. (PubMed id 21397062)1, 2 Stuiver M.... Muller D. (2011)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    6. Genome-wide association study of intracranial aneurys m identifies three new risk loci. (PubMed id 20364137)1, 4 Yasuno K....GA1nel M. (2010)
    7. Blood pressure and hypertension are associated with 7 loci in the Japanese population. (PubMed id 20479155)1, 4 Takeuchi F....Kato N. (2010)
    8. Genome-wide association study reveals genetic risk un derlying Parkinson's disease. (PubMed id 19915575)1, 4 SimA^n-SA!nchez J....Gasser T. (2009)
    9. Genome-wide association study identifies eight loci associated with blood pressure. (PubMed id 19430483)1, 4 Newton-Cheh C....Munroe P.B. (2009)
    10. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 54805 HGNC: 103 AceView: CNNM2 Ensembl:ENSG00000148842 euGenes: HUgn54805
    ECgene: CNNM2 H-InvDB: CNNM2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CNNM2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CNNM2 gene:
    Search GeneIP for patents involving CNNM2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for CNNM2  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for CNNM2  
     OriGene qSTAR qPCR primer pairs in human, mouse for CNNM2   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for CNNM2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CNNM2   OriGene Custom Protein Services for CNNM2  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CNNM2
     QIAGEN SeqTarget long-range PCR primers for resequencing CNNM2
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CNNM2
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CNNM2
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CNNM2
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CNNM2
     GenScript Custom Purified and Recombinant Proteins Services for CNNM2 GenScript cDNA clones with any tag delivered in your preferred vector for CNNM2
     GenScript Custom Assay Services for CNNM2 GenScript Custom Superior Antibodies Services for CNNM2
     GenScript Custom overexpressing Cell Line Services for CNNM2 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in CNNM2 promoter
     Search Chromatin IP Primers for CNNM2
     RT2 qPCR Primer Assay in human, mouse, rat CNNM2
     Search GNC Networks for CNNM2
     SABiosciences Custom PCR Arrays for CNNM2
     Search Tocris compounds for CNNM2
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     CNNM2 antibodies
     Antibodies for CNNM2
     See all of Abcam's Antibodies, Kits and Proteins for CNNM2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for CNNM2
     Antibodies for CNNM2
     ELISAs for CNNM2
     CLIAs for CNNM2
     Search LifeMap BioReagents cell lines for CNNM2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CNNM2
     SwitchGear 3'UTR luciferase reporter plasmids for CNNM2
     SwitchGear Promoter luciferase reporter plasmids for CNNM2
     Search ThermoFisher Antibodies for CNNM2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CNNM2
     inGenious Targeting Laboratory - Custom generated mouse model solutions for CNNM2
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CNNM2
    Customized:
     lentivirus for stable overexpression of CNNM2
     lentivirus expression plasmids for stable overexpression of CNNM2
     adenovirus for overexpression of CNNM2
     LSBio Antibodies in human, mouse, rat for CNNM2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      CNNM2 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4