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CNNM2 Gene

protein-coding   GIFtS: 56
GCID: GC10P104668

Cyclin M2


(Previous symbol: ACDP2)
  See CNNM2-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cyclin M21 2
ACDP21 2 3 5
Ancient Conserved Domain-Containing Protein 22 3
Metal Transporter CNNM22
Cyclin-M23

External Ids:    HGNC: 1031   Entrez Gene: 548052   Ensembl: ENSG000001488427   OMIM: 6078035   UniProtKB: Q9H8M53   

Export aliases for CNNM2 gene to outside databases

Previous GC identifers: GC10P103571 GC10P103911 GC10P104809 GC10P104342 GC10P098313


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CNNM2 Gene:
This gene encodes a member of the ancient conserved domain containing protein family. Members of this protein
family contain a cyclin box motif and have structural similarity to the cyclins. The encoded protein may play an
important role in magnesium homeostasis by mediating the epithelial transport and renal reabsorption of Mg2+.
Mutations in this gene are associated with renal hypomagnesemia. Alternatively spliced transcript variants
encoding multiple isoforms have been observed for this gene. (provided by RefSeq, Dec 2011)

GeneCards Summary for CNNM2 Gene:
CNNM2 (cyclin M2) is a protein-coding gene. Diseases associated with CNNM2 include hypomagnesemia 6, renal, and hypomagnesemia 6. GO annotations related to this gene include adenyl nucleotide binding. An important paralog of this gene is CNNM1.

UniProtKB/Swiss-Prot: CNNM2_HUMAN, Q9H8M5
Function: Divalent metal cation transporter. Mediates transport of divalent metal cations in an order of Mg(2+) >
Co(2+) > Mn(2+) > Sr(2+) > Ba(2+) > Cu(2+) > Fe(2+) (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000010.10  NT_030059.14  NC_018921.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CNNM2 gene promoter:
         AhR   p53   Sp1   CUTL1   YY1   PPAR-alpha   CREB   SEF-1 (1)   Hlf   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCNNM2 promoter sequence
   Search Chromatin IP Primers for CNNM2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CNNM2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q24.32   Ensembl cytogenetic band:  10q24.32   HGNC cytogenetic band: 10q23-q24

CNNM2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CNNM2 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P104668:  view genomic region     (about GC identifiers)

Start:
104,678,050 bp from pter      End:
104,849,978 bp from pter
Size:
171,929 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CNNM2_HUMAN, Q9H8M5 (See protein sequence)
Recommended Name: Metal transporter CNNM2  
Size: 875 amino acids; 96623 Da
Miscellaneous: Shares weak sequence similarity with the cyclin family, hence its name. However, it has no
cyclin-like function in vivo
Sequence caution: Sequence=AAF86374.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=BAA90926.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAB14386.1;
Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=CAI16511.1; Type=Erroneous gene model
prediction; Sequence=CAI16512.1; Type=Erroneous gene model prediction; Sequence=CAI40076.1; Type=Erroneous gene
model prediction; Sequence=CAI40077.1; Type=Erroneous gene model prediction;
Secondary accessions: Q5T569 Q5T570 Q8WU59 Q9H952 Q9NRK5 Q9NXT4
Alternative splicing: 3 isoforms:  Q9H8M5-1   Q9H8M5-2   Q9H8M5-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CNNM2: NX_Q9H8M5

Explore proteomics data for CNNM2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys413
  • Glycosylation2 at Asn112
  • Modification sites at PhosphoSitePlus

  • See CNNM2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_060119.3  NP_951058.1  NP_951059.1  

    ENSEMBL proteins: 
     ENSP00000358894   ENSP00000358891   ENSP00000392875  

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    Cloud-Clone Corp. Proteins for CNNM2

     
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    antibodies-online peptides for CNNM2

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    antibodies-online antibodies for CNNM2 (34 products) 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR000644 CBS_dom
     IPR002550 DUF21
     IPR014710 RmlC-like_jellyroll

    Graphical View of Domain Structure for InterPro Entry Q9H8M5

    ProtoNet protein and cluster: Q9H8M5

    2 Blocks protein domains:
    IPB000644 CBS domain
    IPB002550 CBS


    UniProtKB/Swiss-Prot: CNNM2_HUMAN, Q9H8M5
    Similarity: Belongs to the ACDP family
    Similarity: Contains 2 CBS domains
    Similarity: Contains 1 DUF21 domain


    Find genes that share domains with CNNM2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CNNM2_HUMAN, Q9H8M5
    Function: Divalent metal cation transporter. Mediates transport of divalent metal cations in an order of Mg(2+) >
    Co(2+) > Mn(2+) > Sr(2+) > Ba(2+) > Cu(2+) > Fe(2+) (By similarity)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0030554adenyl nucleotide binding IEA--
         
    Find genes that share ontologies with CNNM2           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for CNNM2

    miRNA
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    miRTarBase miRNAs that target CNNM2:
    hsa-mir-103a-3p (MIRT027164), hsa-mir-128-3p (MIRT022053), hsa-mir-16-5p (MIRT031855), hsa-mir-124-3p (MIRT022806), hsa-mir-26b-5p (MIRT029773)

    Block miRNA regulation of human, mouse, rat CNNM2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CNNM2 (see all 45):
    hsa-miR-579 hsa-miR-15a hsa-miR-503 hsa-let-7a-2* hsa-miR-138-2* hsa-miR-342-3p hsa-miR-424 hsa-miR-9
    SwitchGear 3'UTR luciferase reporter plasmidCNNM2 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 3): CNNM2 (NM_199077)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CNNM2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CNNM2

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CNNM2_HUMAN, Q9H8M5: Cell membrane; Multi-pass membrane protein (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral component of membrane IEA--
    GO:0016323basolateral plasma membrane IMP--

    Find genes that share ontologies with CNNM2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CNNM2
    Interactions:

        Search GeneGlobe Interaction Network for CNNM2

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    Selected Interacting proteins for CNNM2 (Q9H8M53 ENSP000003588944) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RYKP349253, ENSP000002960844I2D: score=1 STRING: ENSP00000296084
    TRAPPC3O436173I2D: score=1 
    UBCENSP000003448184STRING: ENSP00000344818
    UBBENSP000003046974STRING: ENSP00000304697
    TPI1ENSP000003799334STRING: ENSP00000379933
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0010960magnesium ion homeostasis IMP--
    GO:0015693magnesium ion transport IEA--

    Find genes that share ontologies with CNNM2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CNNM2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CNNM2 gene (3 alternative transcripts): 
    NM_017649.4  NM_199076.2  NM_199077.2  

    Unigene Cluster for CNNM2:

    Cyclin M2
    Hs.643509  [show with all ESTs]
    Unigene Representative Sequence: NM_017649
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000369878 ENST00000369875(uc001kwl.3) ENST00000433628 ENST00000475511

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate CNNM2 (see all 45):
    hsa-miR-579 hsa-miR-15a hsa-miR-503 hsa-let-7a-2* hsa-miR-138-2* hsa-miR-342-3p hsa-miR-424 hsa-miR-9
    SwitchGear 3'UTR luciferase reporter plasmidCNNM2 3' UTR sequence
    Inhib. RNA
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): CNNM2 (NM_199077)
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    OriGene qSTAR qPCR primer pairs in human, mouse for CNNM2
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      QuantiTect SYBR Green Assays in human, mouse, rat CNNM2
      QuantiFast Probe-based Assays in human, mouse, rat CNNM2

    Additional mRNA sequence: 

    AF216962.1 AK000071.1 AK023066.1 AK023479.1 BC021222.2 

    6 DOTS entries:

    DT.95157342  DT.412460  DT.438085  DT.306632  DT.95157340  DT.99999302 

    Selected AceView cDNA sequences (see all 103):

    AW611666 AW469552 BX113753 BM727814 F04472 NM_199077 Z44985 NM_017649 
    AA430251 BU632128 NM_199076 AK023479 CA435665 BM562876 AI499732 AW452585 
    Z41609 BM711859 CF890717 CF886849 AI827730 AA430042 AF216962 BC021222 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for CNNM2    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b
    SP1:              -                       -                                       
    SP2:              -                       -           -                           
    SP3:                                                  -                           
    SP4:                                                                              


    ECgene alternative splicing isoforms for CNNM2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CNNM2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGGCCCGGCA
    CNNM2 Expression
    About this image


    CNNM2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Blood (Hematopoietic System)
             Proerythroblasts Hematopoietic Bone Marrow
     
     Brain (Nervous System)
             Thalamus
    CNNM2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CNNM2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.643509

    UniProtKB/Swiss-Prot: CNNM2_HUMAN, Q9H8M5
    Tissue specificity: Widely expressed. Expressed at higher level in brain, kidney and placenta, while it is weakly
    expressed in skeletal muscle. In the kidney, it is expressed in the distal convoluted tubule and the thick
    ascending limb of Henle loop

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CNNM2 gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cnnm21 , 5 cyclin M21, 5 91.66(n)1
    97.83(a)1
      19 (38.97 cM)5
    942191  NM_033569.31  NP_291047.21 
     467616095 
    chicken
    (Gallus gallus)
    Aves CNNM21 cyclin M2 87.66(n)
    96.01(a)
      428975  XM_426532.4  XP_426532.3 
    lizard
    (Anolis carolinensis)
    Reptilia CNNM26
    cyclin M2
    84(a)
    1 ↔ 1
    3(40338500-40470126)
    African clawed frog
    (Xenopus laevis)
    Amphibia BJ066530.12   -- 81.65(n)    BJ066530.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5657021 metal transporter CNNM2-like 76.66(n)
    83.38(a)
      565702  XM_001922770.4  XP_001922805.4 
    fruit fly
    (Drosophila melanogaster)
    Insecta uex1 unextended 55.62(n)
    55.74(a)
      5740320  NM_001110921.3  NP_001104391.2 
    worm
    (Caenorhabditis elegans)
    Secernentea C33D12.23
    CELE_C52D10.121
    CELE_C52D10.121 44(a)
    (best of 3)3
    48.91(n)1
    41.59(a)1
      X(3077278-3081092)3
    1784991  NM_070651.31  NP_503052.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes MAM36
    Protein required for normal mitochondrial morpholo...
    25(a)
    1 → many
    XV(214017-216137) YOL060C
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT4G142301 AT4G14230 46.8(n)
    39.24(a)
      827064  NM_117500.5  NP_193159.3 
    rice
    (Oryza sativa)
    Liliopsida Os05g03953001 Os05g0395300 48.97(n)
    41.59(a)
      4338701  NM_001061997.1  NP_001055462.1 


    ENSEMBL Gene Tree for CNNM2 (if available)
    TreeFam Gene Tree for CNNM2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CNNM2 gene
    CNNM12  CNNM32  CNNM42  
    4 SIMAP similar genes for CNNM2 using alignment to 1 protein entry:     CNNM2_HUMAN:
    DKFZp434I1016    CNNM1    CNNM4    CNNM3

    Find genes that share paralogs with CNNM2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CNNM2 (see all 3051)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0652604
    Hypomagnesemia 6 (HOMG6)4--see VAR_0652602 T I mis40--------
    rs1819070661,2
    C--98317068(+) AAAAAA/GAAACA 3 -- int10--------
    rs340632911,2
    C--98328120(+) TTTTTT/-GGAGA 2 -- int11Minor allele frequency- -:0.50CSA 2
    rs1435681821,2
    C--98332606(+) AAAAA-/GACAACGC 2 -- int10--------
    rs111914691,2
    A--98333970(+) AACAAC/AAAAAA 2 -- int1 trp32Minor allele frequency- A:0.25NA CSA 4
    rs1408910821,2
    C--98342869(+) ATGAT-/ACTG  
            
    TAGAG
    2 -- int10--------
    rs1115954781,2
    C--98355943(+) CAAAC-/TTATGAC 2 -- int11Minor allele frequency- TT:0.00CSA 2
    rs1414815031,2
    C--98362092(+) TAAGA-/ATATATA 2 -- int10--------
    rs57874781,2
    C,F--98367789(+) GTATT-/CCCCCC 2 -- int1 trp33Minor allele frequency- C:0.33NA CSA 6
    rs2008771011,2
    C--98367789(+) GTATTC/TCCCCC 2 -- int10--------

    HapMap Linkage Disequilibrium report for CNNM2 (104678050 - 104849978 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CNNM2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2449517CNV Insertion19546169
    nsv7528CNV Loss18451855

    Human Gene Mutation Database (HGMD): CNNM2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CNNM2
    DNA2.0 Custom Variant and Variant Library Synthesis for CNNM2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607803   
    OMIM disorders: 613882  
    UniProtKB/Swiss-Prot: CNNM2_HUMAN, Q9H8M5
  • Hypomagnesemia 6 (HOMG6) [MIM:613882]: A renal disease characterized by severely lowered serum magnesium
    levels in the absence of other electrolyte disturbances. Affected individuals show an inappropriately normal
    urinary magnesium excretion, demonstrating a defect in tubular reabsorption. Age of clinical onset is highly
    variable and some affected individuals are asymptomatic. Note=The disease is caused by mutations affecting the
    gene represented in this entry

  • 3 diseases for CNNM2:    
    About MalaCards
    hypomagnesemia 6, renal    hypomagnesemia 6    renal hypomagnesemia 4


    Find genes that share disorders with CNNM2           About GenesLikeMe

    Genetic Association Database (GAD): CNNM2
    Human Genome Epidemiology (HuGE) Navigator: CNNM2 (5 documents)

    Export disorders for CNNM2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CNNM2 gene, integrated from 10 sources (see all 30):
    (articles sorted by number of sources associating them with CNNM2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genome-wide association study identifies five new schizophrenia loci. (PubMed id 21926974)1, 4 (Nat. Genet. 2011)
    2. Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. (PubMed id 21378990)1, 4 Schunkert H....Samani N.J. (Nat. Genet. 2011)
    3. A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease. (PubMed id 21378988)1, 4 (Nat. Genet. 2011)
    4. CNNM2, encoding a basolateral protein required for renal Mg2+ handling, is mutated in dominant hypomagnesemia. (PubMed id 21397062)1, 2 Stuiver M.... Muller D. (Am. J. Hum. Genet. 2011)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    6. Genome-wide association study of intracranial aneurysm identifies three new risk loci. (PubMed id 20364137)1, 4 Yasuno K....GA1nel M. (Nat. Genet. 2010)
    7. Blood pressure and hypertension are associated with 7 loci in the Japanese population. (PubMed id 20479155)1, 4 Takeuchi F....Kato N. (Circulation 2010)
    8. Genome-wide association study reveals genetic risk underlying Parkinson's disease. (PubMed id 19915575)1, 4 SimA^n-SA!nchez J....Gasser T. (Nat. Genet. 2009)
    9. Genome-wide association study identifies eight loci associated with blood pressure. (PubMed id 19430483)1, 4 Newton-Cheh C....Munroe P.B. (Nat. Genet. 2009)
    10. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (Am. J. Hum. Genet. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 54805 HGNC: 103 AceView: CNNM2 Ensembl:ENSG00000148842 euGenes: HUgn54805
    ECgene: CNNM2 H-InvDB: CNNM2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CNNM2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CNNM2 gene:
    Search GeneIP for patents involving CNNM2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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