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Aliases for CNNM1 Gene

Aliases for CNNM1 Gene

  • Cyclin And CBS Domain Divalent Metal Cation Transport Mediator 1 2 3
  • ACDP1 3 4 6
  • Ancient Conserved Domain-Containing Protein 1 3 4
  • Cyclin M1 2 3
  • Cyclin-M1 3 4
  • Ancient Conserved Domain Protein 1 3
  • Metal Transporter CNNM1 3
  • CLP-1 3

External Ids for CNNM1 Gene

Previous Symbols for CNNM1 Gene

  • ACDP1

Summaries for CNNM1 Gene

GeneCards Summary for CNNM1 Gene

CNNM1 (Cyclin And CBS Domain Divalent Metal Cation Transport Mediator 1) is a Protein Coding gene. GO annotations related to this gene include adenyl nucleotide binding. An important paralog of this gene is CNNM2.

UniProtKB/Swiss-Prot for CNNM1 Gene

  • Probable metal transporter.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CNNM1 Gene

Genomics for CNNM1 Gene

Genomic Location for CNNM1 Gene

Start:
99,329,099 bp from pter
End:
99,394,330 bp from pter
Size:
65,232 bases
Orientation:
Plus strand

Genomic View for CNNM1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CNNM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CNNM1 Gene

Regulatory Elements for CNNM1 Gene

Proteins for CNNM1 Gene

  • Protein details for CNNM1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NRU3-CNNM1_HUMAN
    Recommended name:
    Metal transporter CNNM1
    Protein Accession:
    Q9NRU3
    Secondary Accessions:
    • Q4QQG7
    • Q4QQH8
    • Q4QQP9
    • Q9NT45

    Protein attributes for CNNM1 Gene

    Size:
    951 amino acids
    Molecular mass:
    104351 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Shares weak sequence similarity with the cyclin family, hence its name. However, it has no cyclin-like function in vivo
    SequenceCaution:
    • Sequence=AAF86357.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH98103.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH98279.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH98307.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAB70798.1; Type=Frameshift; Positions=839, 874; Evidence={ECO:0000305};

    Alternative splice isoforms for CNNM1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CNNM1 Gene

Proteomics data for CNNM1 Gene at MOPED

Post-translational modifications for CNNM1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CNNM1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CNNM1 Gene

Domains for CNNM1 Gene

Protein Domains for CNNM1 Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

CNNM1_HUMAN
Domain:
  • Contains 2 CBS domains.:
    • Q9NRU3
  • Contains 1 DUF21 domain.:
    • Q9NRU3
Family:
  • Belongs to the ACDP family.:
    • Q9NRU3
genes like me logo Genes that share domains with CNNM1: view

No data available for Gene Families for CNNM1 Gene

Function for CNNM1 Gene

Molecular function for CNNM1 Gene

UniProtKB/Swiss-Prot Function: Probable metal transporter.

Gene Ontology (GO) - Molecular Function for CNNM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030554 adenyl nucleotide binding --
genes like me logo Genes that share ontologies with CNNM1: view
genes like me logo Genes that share phenotypes with CNNM1: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CNNM1 Gene

Localization for CNNM1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CNNM1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CNNM1 Gene COMPARTMENTS Subcellular localization image for CNNM1 gene
Compartment Confidence
plasma membrane 5
cytosol 1
endoplasmic reticulum 1
golgi apparatus 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CNNM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CNNM1: view

Pathways for CNNM1 Gene

SuperPathways for CNNM1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CNNM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport IEA --
genes like me logo Genes that share ontologies with CNNM1: view

No data available for Pathways by source for CNNM1 Gene

Transcripts for CNNM1 Gene

Unigene Clusters for CNNM1 Gene

Cyclin M1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CNNM1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12 ^ 13 ^ 14a · 14b
SP1: - - - - -
SP2: - - - - - -
SP3: - - -
SP4:
SP5:
SP6: -
SP7:

Relevant External Links for CNNM1 Gene

GeneLoc Exon Structure for
CNNM1
ECgene alternative splicing isoforms for
CNNM1

Expression for CNNM1 Gene

mRNA expression in normal human tissues for CNNM1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CNNM1 Gene

This gene is overexpressed in Brain - Cortex (4.6), Brain - Nucleus accumbens (basal ganglia) (4.5), Brain - Frontal Cortex (BA9) (4.4), and Brain - Putamen (basal ganglia) (4.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CNNM1 Gene

SOURCE GeneReport for Unigene cluster for CNNM1 Gene Hs.274579

mRNA Expression by UniProt/SwissProt for CNNM1 Gene

Q9NRU3-CNNM1_HUMAN
Tissue specificity: Restricted to brain and testis.
genes like me logo Genes that share expressions with CNNM1: view

Orthologs for CNNM1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CNNM1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CNNM1 36
  • 97.64 (n)
  • 97.77 (a)
CNNM1 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CNNM1 36
  • 91.24 (n)
  • 95.39 (a)
CNNM1 37
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CNNM1 36
  • 91.55 (n)
  • 96.2 (a)
CNNM1 37
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cnnm1 36
  • 89.34 (n)
  • 94.64 (a)
Cnnm1 16
Cnnm1 37
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CNNM1 37
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CNNM1 37
  • 59 (a)
OneToOne
chicken
(Gallus gallus)
Aves CNNM1 36
  • 78.13 (n)
  • 81.56 (a)
CNNM1 37
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CNNM1 37
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cnnm1 36
  • 69.67 (n)
  • 74.16 (a)
Str.13101 36
zebrafish
(Danio rerio)
Actinopterygii cnnm1 37
  • 70 (a)
OneToOne
LOC562504 36
  • 64.83 (n)
  • 62.33 (a)
fruit fly
(Drosophila melanogaster)
Insecta uex 37
  • 34 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea R13G10.4 37
  • 19 (a)
ManyToMany
C52D10.12 38
  • 31 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MAM3 37
  • 22 (a)
OneToMany
Species with no ortholog for CNNM1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CNNM1 Gene

ENSEMBL:
Gene Tree for CNNM1 (if available)
TreeFam:
Gene Tree for CNNM1 (if available)

Paralogs for CNNM1 Gene

Paralogs for CNNM1 Gene

Selected SIMAP similar genes for CNNM1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with CNNM1: view

Variants for CNNM1 Gene

Sequence variations from dbSNP and Humsavar for CNNM1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs1132364 -- 99,394,180(+) CCTGT(C/T)ACCAC utr-variant-3-prime, nc-transcript-variant
rs1892508 -- 99,357,183(+) TTCTG(A/C)CTCTA intron-variant
rs1892509 -- 99,365,844(+) TCAGA(A/G)GGTCC intron-variant
rs1892510 -- 99,370,406(+) TGCCT(A/C)GTTTC intron-variant
rs1892511 -- 99,370,545(+) TTCCA(A/T)ATCAT intron-variant

Relevant External Links for CNNM1 Gene

HapMap Linkage Disequilibrium report
CNNM1

No data available for Structural Variations from Database of Genomic Variants (DGV) for CNNM1 Gene

Disorders for CNNM1 Gene

(2) University of Copenhagen DISEASES for CNNM1 Gene

Relevant External Links for CNNM1

Genetic Association Database (GAD)
CNNM1
Human Genome Epidemiology (HuGE) Navigator
CNNM1
genes like me logo Genes that share disorders with CNNM1: view

No data available for UniProtKB/Swiss-Prot for CNNM1 Gene

Publications for CNNM1 Gene

  1. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 4
  2. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A. … Goate A. (Am. J. Hum. Genet. 2006) 3 49
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 49
  4. Purification, crystallization and preliminary crystallographic analysis of the CBS pair of the human metal transporter CNNM4. (PMID: 21393841) GA^mez GarcA-a I. … MartA-nez-Cruz L.A. (Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 2011) 2 3
  5. Molecular cloning and characterization of a novel gene family of four ancient conserved domain proteins (ACDP). (PMID: 12657465) Wang C.-Y. … She J.-X. (Gene 2003) 3 4

Products for CNNM1 Gene

Sources for CNNM1 Gene

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