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Aliases for CNNM1 Gene

Aliases for CNNM1 Gene

  • Cyclin And CBS Domain Divalent Metal Cation Transport Mediator 1 2 3
  • Ancient Conserved Domain-Containing Protein 1 3 4
  • Cyclin M1 2 3
  • Cyclin-M1 3 4
  • ACDP1 3 4
  • Ancient Conserved Domain Protein 1 3
  • CLP-1 3

External Ids for CNNM1 Gene

Previous HGNC Symbols for CNNM1 Gene

  • ACDP1

Previous GeneCards Identifiers for CNNM1 Gene

  • GC10P099983
  • GC10P100323
  • GC10P101221
  • GC10P100754
  • GC10P101080
  • GC10P094715

Summaries for CNNM1 Gene

GeneCards Summary for CNNM1 Gene

CNNM1 (Cyclin And CBS Domain Divalent Metal Cation Transport Mediator 1) is a Protein Coding gene. Diseases associated with CNNM1 include urofacial syndrome 1 and cone-rod dystrophy. GO annotations related to this gene include adenyl nucleotide binding. An important paralog of this gene is CNNM2.

UniProtKB/Swiss-Prot for CNNM1 Gene

  • Probable metal transporter.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CNNM1 Gene

Genomics for CNNM1 Gene

Regulatory Elements for CNNM1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CNNM1 Gene

99,329,099 bp from pter
99,394,330 bp from pter
65,232 bases
Plus strand

Genomic View for CNNM1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CNNM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CNNM1 Gene

Proteins for CNNM1 Gene

  • Protein details for CNNM1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Metal transporter CNNM1
    Protein Accession:
    Secondary Accessions:
    • Q4QQG7
    • Q4QQH8
    • Q4QQP9
    • Q9NT45

    Protein attributes for CNNM1 Gene

    951 amino acids
    Molecular mass:
    104351 Da
    Quaternary structure:
    No Data Available
    • Shares weak sequence similarity with the cyclin family, hence its name. However, it has no cyclin-like function in vivo
    • Sequence=AAF86357.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH98103.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH98279.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH98307.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAB70798.1; Type=Frameshift; Positions=839, 874; Evidence={ECO:0000305};

    Alternative splice isoforms for CNNM1 Gene


neXtProt entry for CNNM1 Gene

Proteomics data for CNNM1 Gene at MOPED

Post-translational modifications for CNNM1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CNNM1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CNNM1 Gene

Domains & Families for CNNM1 Gene

Protein Domains for CNNM1 Gene


Suggested Antigen Peptide Sequences for CNNM1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 2 CBS domains.
  • Belongs to the ACDP family.
  • Contains 2 CBS domains.
  • Contains 1 DUF21 domain.
  • Belongs to the ACDP family.
genes like me logo Genes that share domains with CNNM1: view

No data available for Gene Families for CNNM1 Gene

Function for CNNM1 Gene

Molecular function for CNNM1 Gene

UniProtKB/Swiss-Prot Function:
Probable metal transporter.
genes like me logo Genes that share phenotypes with CNNM1: view

miRNA for CNNM1 Gene

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CNNM1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targets and HOMER Transcription for CNNM1 Gene

Localization for CNNM1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CNNM1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for CNNM1 Gene COMPARTMENTS Subcellular localization image for CNNM1 gene
Compartment Confidence
plasma membrane 3

Gene Ontology (GO) - Cellular Components for CNNM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CNNM1: view

Pathways & Interactions for CNNM1 Gene

SuperPathways for CNNM1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CNNM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport IEA --
genes like me logo Genes that share ontologies with CNNM1: view

No data available for Pathways by source and SIGNOR curated interactions for CNNM1 Gene

Drugs & Compounds for CNNM1 Gene

No Compound Related Data Available

Transcripts for CNNM1 Gene

Unigene Clusters for CNNM1 Gene

Cyclin M1:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CNNM1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CNNM1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12 ^ 13 ^ 14a · 14b
SP1: - - - - -
SP2: - - - - - -
SP3: - - -
SP6: -

Relevant External Links for CNNM1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CNNM1 Gene

mRNA expression in normal human tissues for CNNM1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CNNM1 Gene

This gene is overexpressed in Brain - Cortex (x4.6), Brain - Nucleus accumbens (basal ganglia) (x4.5), Brain - Frontal Cortex (BA9) (x4.4), and Brain - Putamen (basal ganglia) (x4.4).

Protein differential expression in normal tissues from HIPED for CNNM1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (30.3) and Adipocyte (28.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CNNM1 Gene

SOURCE GeneReport for Unigene cluster for CNNM1 Gene Hs.274579

mRNA Expression by UniProt/SwissProt for CNNM1 Gene

Tissue specificity: Restricted to brain and testis.
genes like me logo Genes that share expression patterns with CNNM1: view

Protein tissue co-expression partners for CNNM1 Gene

Primer Products

In Situ Assay Products

Orthologs for CNNM1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CNNM1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CNNM1 35
  • 91.24 (n)
  • 95.39 (a)
CNNM1 36
  • 95 (a)
(Canis familiaris)
Mammalia CNNM1 35
  • 91.55 (n)
  • 96.2 (a)
CNNM1 36
  • 96 (a)
(Mus musculus)
Mammalia Cnnm1 35
  • 89.34 (n)
  • 94.64 (a)
Cnnm1 16
Cnnm1 36
  • 95 (a)
(Pan troglodytes)
Mammalia CNNM1 35
  • 97.64 (n)
  • 97.77 (a)
CNNM1 36
  • 99 (a)
(Monodelphis domestica)
Mammalia CNNM1 36
  • 82 (a)
(Ornithorhynchus anatinus)
Mammalia CNNM1 36
  • 59 (a)
(Gallus gallus)
Aves CNNM1 35
  • 78.13 (n)
  • 81.56 (a)
CNNM1 36
  • 77 (a)
(Anolis carolinensis)
Reptilia CNNM1 36
  • 70 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cnnm1 35
  • 69.67 (n)
  • 74.16 (a)
Str.13101 35
(Danio rerio)
Actinopterygii LOC562504 35
  • 64.83 (n)
  • 62.33 (a)
cnnm1 36
  • 70 (a)
fruit fly
(Drosophila melanogaster)
Insecta uex 36
  • 34 (a)
(Caenorhabditis elegans)
Secernentea C52D10.12 37
  • 31 (a)
R13G10.4 36
  • 19 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MAM3 36
  • 22 (a)
Species with no ortholog for CNNM1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CNNM1 Gene

Gene Tree for CNNM1 (if available)
Gene Tree for CNNM1 (if available)

Paralogs for CNNM1 Gene

Paralogs for CNNM1 Gene

(4) SIMAP similar genes for CNNM1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with CNNM1: view

Variants for CNNM1 Gene

Sequence variations from dbSNP and Humsavar for CNNM1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs1132364 -- 99,394,180(+) CCTGT(C/T)ACCAC utr-variant-3-prime
rs1892508 -- 99,357,183(+) TTCTG(A/C)CTCTA intron-variant
rs1892509 -- 99,365,844(+) TCAGA(A/G)GGTCC intron-variant
rs1892510 -- 99,370,406(+) TGCCT(A/C)GTTTC intron-variant
rs1892511 -- 99,370,545(+) TTCCA(A/T)ATCAT intron-variant

Variation tolerance for CNNM1 Gene

Residual Variation Intolerance Score: 26.33% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.31; 62.92% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CNNM1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CNNM1 Gene

Disorders for CNNM1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for CNNM1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
urofacial syndrome 1
  • urofacial syndrome
cone-rod dystrophy
  • cone-rod dystrophy 5
- elite association
Search CNNM1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CNNM1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with CNNM1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CNNM1 Gene

Publications for CNNM1 Gene

  1. Purification, crystallization and preliminary crystallographic analysis of the CBS pair of the human metal transporter CNNM4. (PMID: 21393841) GA^mez GarcA-a I. … MartA-nez-Cruz L.A. (Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 2011) 2 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  3. A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci. (PMID: 22412388) Kenny E.E. … Peter I. (PLoS Genet. 2012) 67
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 67
  5. The full-ORF clone resource of the German cDNA consortium. (PMID: 17974005) Bechtel S. … Schupp I. (BMC Genomics 2007) 67

Products for CNNM1 Gene

Sources for CNNM1 Gene

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