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Aliases for CNN3 Gene

Aliases for CNN3 Gene

  • Calponin 3 2 3
  • Calponin 3, Acidic 2 5
  • Calponin, Acidic Isoform 4

External Ids for CNN3 Gene

Previous GeneCards Identifiers for CNN3 Gene

  • GC01M095763
  • GC01M094568
  • GC01M094713
  • GC01M094834
  • GC01M095074
  • GC01M095135
  • GC01M095362
  • GC01M093484

Summaries for CNN3 Gene

Entrez Gene Summary for CNN3 Gene

  • This gene encodes a protein with a markedly acidic C terminus; the basic N-terminus is highly homologous to the N-terminus of a related gene, CNN1. Members of the CNN gene family all contain similar tandemly repeated motifs. This encoded protein is associated with the cytoskeleton but is not involved in contraction. [provided by RefSeq, Jul 2008]

GeneCards Summary for CNN3 Gene

CNN3 (Calponin 3) is a Protein Coding gene. GO annotations related to this gene include actin binding and calmodulin binding. An important paralog of this gene is CNN2.

UniProtKB/Swiss-Prot for CNN3 Gene

  • Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CNN3 Gene

Genomics for CNN3 Gene

Regulatory Elements for CNN3 Gene

Promoters for CNN3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CNN3 on UCSC Golden Path with GeneCards custom track

Genomic Location for CNN3 Gene

Chromosome:
1
Start:
94,896,949 bp from pter
End:
94,927,278 bp from pter
Size:
30,330 bases
Orientation:
Minus strand

Genomic View for CNN3 Gene

Genes around CNN3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CNN3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CNN3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CNN3 Gene

Proteins for CNN3 Gene

  • Protein details for CNN3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15417-CNN3_HUMAN
    Recommended name:
    Calponin-3
    Protein Accession:
    Q15417
    Secondary Accessions:
    • B4DFK6
    • B4DP09
    • F8WA86
    • Q6FHA7

    Protein attributes for CNN3 Gene

    Size:
    329 amino acids
    Molecular mass:
    36414 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CNN3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CNN3 Gene

Proteomics data for CNN3 Gene at MOPED

Post-translational modifications for CNN3 Gene

  • Ubiquitination at Lys 256
  • Modification sites at PhosphoSitePlus

Other Protein References for CNN3 Gene

No data available for DME Specific Peptides for CNN3 Gene

Domains & Families for CNN3 Gene

Graphical View of Domain Structure for InterPro Entry

Q15417

UniProtKB/Swiss-Prot:

CNN3_HUMAN :
  • Contains 1 CH (calponin-homology) domain.
  • Belongs to the calponin family.
  • Contains 3 calponin-like repeats.
Domain:
  • Contains 1 CH (calponin-homology) domain.
Family:
  • Belongs to the calponin family.
Similarity:
  • Contains 3 calponin-like repeats.
genes like me logo Genes that share domains with CNN3: view

No data available for Gene Families for CNN3 Gene

Function for CNN3 Gene

Molecular function for CNN3 Gene

GENATLAS Biochemistry:
calponin,acidic,36kDa,cytoskeletal protein,ubiquitously expressed in smooth muscle and non smooth muscle tissues,actin,calmodulin,tropomyosin binding,downregulated during dedifferentiation of vascular smooth muscle cell
UniProtKB/Swiss-Prot Function:
Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity.

Gene Ontology (GO) - Molecular Function for CNN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA --
genes like me logo Genes that share ontologies with CNN3: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CNN3 Gene

Localization for CNN3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CNN3 Gene COMPARTMENTS Subcellular localization image for CNN3 gene
Compartment Confidence
cytoskeleton 5
cytosol 4
nucleus 2
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CNN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0030425 dendrite IEA --
GO:0043025 neuronal cell body IEA --
genes like me logo Genes that share ontologies with CNN3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CNN3 Gene

Pathways & Interactions for CNN3 Gene

SuperPathways for CNN3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CNN3 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CNN3 Gene

Drugs & Compounds for CNN3 Gene

No Compound Related Data Available

Transcripts for CNN3 Gene

Unigene Clusters for CNN3 Gene

Calponin 3, acidic:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CNN3 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b
SP1: - - - - - - -
SP2: - - - - -
SP3: -
SP4: -
SP5:
SP6:
SP7: - - - - -

Relevant External Links for CNN3 Gene

GeneLoc Exon Structure for
CNN3
ECgene alternative splicing isoforms for
CNN3

Expression for CNN3 Gene

mRNA expression in normal human tissues for CNN3 Gene

Protein differential expression in normal tissues from HIPED for CNN3 Gene

This gene is overexpressed in Bone marrow stromal cell (13.8) and Uterus (11.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CNN3 Gene



SOURCE GeneReport for Unigene cluster for CNN3 Gene Hs.483454

mRNA Expression by UniProt/SwissProt for CNN3 Gene

Q15417-CNN3_HUMAN
Tissue specificity: Expressed in both non-smooth muscle tissues as well as smooth muscle tissues.
genes like me logo Genes that share expression patterns with CNN3: view

Protein tissue co-expression partners for CNN3 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for CNN3 Gene

Orthologs for CNN3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CNN3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CNN3 35
  • 94.83 (n)
  • 99.39 (a)
CNN3 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CNN3 35
  • 91.53 (n)
  • 98.07 (a)
CNN3 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cnn3 35
  • 90.07 (n)
  • 97.87 (a)
Cnn3 16
Cnn3 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CNN3 35
  • 99.8 (n)
  • 99.7 (a)
CNN3 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cnn3 35
  • 90.07 (n)
  • 97.57 (a)
oppossum
(Monodelphis domestica)
Mammalia CNN3 36
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CNN3 36
  • 95 (a)
OneToOne
chicken
(Gallus gallus)
Aves CNN3 35
  • 83.6 (n)
  • 94.21 (a)
CNN3 36
  • 94 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CNN3 36
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cnn3 35
  • 79.13 (n)
  • 88.45 (a)
MGC76140 35
African clawed frog
(Xenopus laevis)
Amphibia cnn3-prov 35
zebrafish
(Danio rerio)
Actinopterygii cnn3a 35
  • 74.92 (n)
  • 83.79 (a)
wufe49h10 35
cnn3b 36
  • 81 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001313 35
  • 47.51 (n)
  • 40.88 (a)
fruit fly
(Drosophila melanogaster)
Insecta Chd64 35
  • 49.07 (n)
  • 39.44 (a)
Mp20 36
  • 37 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea cpn-2 36
  • 37 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SCP1 36
  • 26 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7148 36
  • 44 (a)
OneToMany
Species with no ortholog for CNN3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CNN3 Gene

ENSEMBL:
Gene Tree for CNN3 (if available)
TreeFam:
Gene Tree for CNN3 (if available)

Paralogs for CNN3 Gene

Paralogs for CNN3 Gene

(14) SIMAP similar genes for CNN3 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for CNN3 Gene

genes like me logo Genes that share paralogs with CNN3: view

Variants for CNN3 Gene

Sequence variations from dbSNP and Humsavar for CNN3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs10803 -- 94,897,723(-) GAGCT(C/T)AGTAT utr-variant-3-prime
rs864553 -- 94,912,869(-) AGTGC(C/G)CTAGA intron-variant
rs859040 -- 94,919,114(+) GCAAA(G/T)AATGC intron-variant
rs859041 -- 94,918,519(+) aaaaa(A/C)aGTCG intron-variant
rs859042 -- 94,918,041(+) AGTCT(C/T)AGCAC intron-variant

Variation tolerance for CNN3 Gene

Residual Variation Intolerance Score: 48.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.74; 32.94% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CNN3 Gene

HapMap Linkage Disequilibrium report
CNN3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CNN3 Gene

Disorders for CNN3 Gene

Relevant External Links for CNN3

Genetic Association Database (GAD)
CNN3
Human Genome Epidemiology (HuGE) Navigator
CNN3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CNN3

No disorders were found for CNN3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CNN3 Gene

Publications for CNN3 Gene

  1. Molecular cloning and gene mapping of human basic and acidic calponins. (PMID: 8526917) Maguchi M. … Hiwada K. (Biochem. Biophys. Res. Commun. 1995) 2 3 4 67
  2. An emerin "proteome": purification of distinct emerin-containing complexes from HeLa cells suggests molecular basis for diverse roles including gene regulation, mRNA splicing, signaling, mechanosensing, and nuclear architecture. (PMID: 17620012) Holaska J.M. … Wilson K.L. (Biochemistry 2007) 3 23
  3. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3

Products for CNN3 Gene

Sources for CNN3 Gene

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