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CNN3 Gene

protein-coding   GIFtS: 54
GCID: GC01M095362

Calponin 3, Acidic

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Calponin 3, Acidic1 2
Calponin, Acidic Isoform2 3
calponin-32
DJ639P13.2.2 (Acidic Calponin 3)2

External Ids:    HGNC: 21571   Entrez Gene: 12662   Ensembl: ENSG000001175197   OMIM: 6023745   UniProtKB: Q154173   

Export aliases for CNN3 gene to outside databases

Previous GC identifers: GC01M095763 GC01M094568 GC01M094713 GC01M094834 GC01M095074 GC01M095135 GC01M093484


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CNN3 Gene:
This gene encodes a protein with a markedly acidic C terminus; the basic N-terminus is highly homologous to the
N-terminus of a related gene, CNN1. Members of the CNN gene family all contain similar tandemly repeated motifs.
This encoded protein is associated with the cytoskeleton but is not involved in contraction. (provided by RefSeq,
Jul 2008)

GeneCards Summary for CNN3 Gene:
CNN3 (calponin 3, acidic) is a protein-coding gene. GO annotations related to this gene include microtubule binding and actin binding. An important paralog of this gene is TAGLN2.

UniProtKB/Swiss-Prot: CNN3_HUMAN, Q15417
Function: Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle
contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of
calponin with actin inhibits the actomyosin Mg-ATPase activity




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CNN3 gene promoter:
         ER-alpha   Pax-5   AML1a   p53   AP-4   Nkx2-5   XBP-1   C/EBPalpha   c-Myb   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCNN3 promoter sequence
   Search Chromatin IP Primers for CNN3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CNN3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p22-p21   Ensembl cytogenetic band:  1p21.3   HGNC cytogenetic band: 1p22-p21

CNN3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CNN3 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M095362:  view genomic region     (about GC identifiers)

Start:
95,362,507 bp from pter      End:
95,392,834 bp from pter
Size:
30,328 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CNN3_HUMAN, Q15417 (See protein sequence)
Recommended Name: Calponin-3  
Size: 329 amino acids; 36414 Da
Secondary accessions: Q6FHA7

Explore the universe of human proteins at neXtProt for CNN3: NX_Q15417

Explore proteomics data for CNN3 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys256
  • Modification sites at PhosphoSitePlus

  • See CNN3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001272984.1  NP_001272985.1  NP_001830.1  

    ENSEMBL proteins: 
     ENSP00000359225   ENSP00000401452   ENSP00000437665   ENSP00000377752   ENSP00000440081  

    CNN3 Human Recombinant Protein Products:

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    OriGene MassSpec for CNN3
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    Novus Biologicals CNN3 Proteins
    Novus Biologicals CNN3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CNN3

     
    Search eBioscience for Proteins for CNN3 

     
    antibodies-online proteins for CNN3 (6 products) 

     
    antibodies-online peptides for CNN3

    CNN3 Antibody Products:

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    antibodies-online antibodies for CNN3 (21 products) 

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    Cloud-Clone Corp. ELISAs for CNN3
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR001997 Calponin
     IPR001715 CH-domain
     IPR003096 SM22_calponin
     IPR000557 Calponin_repeat

    Graphical View of Domain Structure for InterPro Entry Q15417

    ProtoNet protein and cluster: Q15417

    3 Blocks protein domains:
    IPB001715 Calponin-like actin-binding
    IPB001997 Calponin signature
    IPB003247 Calponin-like actin-binding subtype


    UniProtKB/Swiss-Prot: CNN3_HUMAN, Q15417
    Similarity: Belongs to the calponin family
    Similarity: Contains 3 calponin-like repeats
    Similarity: Contains 1 CH (calponin-homology) domain


    Find genes that share domains with CNN3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CNN3_HUMAN, Q15417
    Function: Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle
    contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of
    calponin with actin inhibits the actomyosin Mg-ATPase activity

         Genatlas biochemistry entry for CNN3:
    calponin,acidic,36kDa,cytoskeletal protein,ubiquitously expressed in smooth muscle and non smooth muscle
    tissues,actin,calmodulin,tropomyosin binding,downregulated during dedifferentiation of vascular smooth muscle
    cell

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding IEA--
    GO:0005515protein binding ----
    GO:0005516calmodulin binding IEA--
    GO:0005523tropomyosin binding ----
    GO:0008017microtubule binding ----
         
    Find genes that share ontologies with CNN3           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for CNN3

    miRNA
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    miRTarBase miRNAs that target CNN3:
    hsa-mir-28-5p (MIRT050000), hsa-mir-122-5p (MIRT023223), hsa-mir-16-5p (MIRT051220), hsa-mir-652-3p (MIRT039532), hsa-mir-1 (MIRT003526), hsa-mir-7-5p (MIRT004059), hsa-mir-15a-5p (MIRT051326), hsa-mir-124-3p (MIRT022443), hsa-mir-375 (MIRT019744)

    Block miRNA regulation of human, mouse, rat CNN3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CNN3 (see all 33):
    hsa-miR-3607-3p hsa-miR-429 hsa-miR-513a-5p hsa-miR-128 hsa-miR-16-1* hsa-miR-508-3p hsa-miR-124 hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmidCNN3 3' UTR sequence
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    Predesigned siRNA for gene silencing in human, mouse, rat CNN3

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: CNN3 (NM_001839)
    Sino Biological Human cDNA Clone for CNN3
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CNN3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CNN3

    Cell Line
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CNN3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    cytoskeleton2
    nucleus2
    extracellular1
    mitochondrion1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0014069postsynaptic density ----
    GO:0043025neuronal cell body ----
    GO:0043197dendritic spine ----

    Find genes that share ontologies with CNN3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CNN3
    Interactions:

        Search GeneGlobe Interaction Network for CNN3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

    Selected Interacting proteins for CNN3 (Q154173 ENSP000003592254) via UniProtKB, MINT, STRING, and/or I2D (see all 25)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FYNP062413, ENSP000003576564I2D: score=2 STRING: ENSP00000357656
    MAPK1P284823, ENSP000002158324I2D: score=1 STRING: ENSP00000215832
    SLX4Q8IY923, ENSP000002940084I2D: score=1 STRING: ENSP00000294008
    ATG5Q9H1Y03, ENSP000003433134I2D: score=1 STRING: ENSP00000343313
    LCP1P137963, ENSP000003157574I2D: score=5 STRING: ENSP00000315757
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006939smooth muscle contraction ----
    GO:0030855epithelial cell differentiation IEP--
    GO:0031032actomyosin structure organization IEA--
    GO:0032780negative regulation of ATPase activity ----

    Find genes that share ontologies with CNN3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CNN3



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CNN3 gene (3 alternative transcripts): 
    NM_001286055.1  NM_001286056.1  NM_001839.4  

    Unigene Cluster for CNN3:

    Calponin 3, acidic
    Hs.483454  [show with all ESTs]
    Unigene Representative Sequence: NM_001839
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000370206(uc010otv.2 uc001dqz.4 uc010otx.2) ENST00000461018
    ENST00000487539 ENST00000415017 ENST00000474409 ENST00000538964 ENST00000394202
    ENST00000545882
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate CNN3 (see all 33):
    hsa-miR-3607-3p hsa-miR-429 hsa-miR-513a-5p hsa-miR-128 hsa-miR-16-1* hsa-miR-508-3p hsa-miR-124 hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmidCNN3 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for CNN3
    Predesigned siRNA for gene silencing in human, mouse, rat CNN3
    Clone
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    OriGene clones in human, mouse for CNN3 (see all 6)
    OriGene ORF clones in mouse, rat for CNN3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CNN3 (NM_001839)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CNN3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CNN3
    Primer
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    OriGene qPCR primer pairs and template standards for CNN3
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    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat CNN3
      QuantiTect SYBR Green Assays in human, mouse, rat CNN3
      QuantiFast Probe-based Assays in human, mouse, rat CNN3

    Additional mRNA sequence: 

    AK294141.1 AK298145.1 AK312370.1 AK316398.1 BC025372.2 CR541848.1 S80562.1 

    18 DOTS entries:

    DT.91707091  DT.95260960  DT.100038228  DT.100828373  DT.40106743  DT.100828369  DT.100828372  DT.91882574 
    DT.100828370  DT.100038227  DT.100828377  DT.100828378  DT.121389516  DT.121389546  DT.431783  DT.443895 
    DT.91807008  DT.95260941 

    Selected AceView cDNA sequences (see all 407):

    CF242801 BE298662 BG250828 BQ881069 BU542521 T32862 BE531089 BQ212786 
    AA346375 AW150149 BU167516 CR619086 AI678797 AA480367 CD250768 BU150139 
    AU280817 BX418686 CR622382 BX458262 BP372479 BM696718 AI186941 AA149803 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CNN3 (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b
    SP1:              -     -     -     -     -           -                 -                                 
    SP2:                          -     -     -           -                 -                                 
    SP3:                                                                    -                                 
    SP4:                                                  -                                                   
    SP5:                                                                                                      


    ECgene alternative splicing isoforms for CNN3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CNN3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TACAAAAGTG
    CNN3 Expression
    About this image


    CNN3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 18) fully expand
     
     Neural Tube (Nervous System)
             Telencephalon
     
     Brain (Nervous System)
             Cerebral Cortex
     
     Colon (Gastrointestinal Tract)
     
     Uterus (Reproductive System)
     
     Thyroid (Endocrine System)
    CNN3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CNN3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.483454

    UniProtKB/Swiss-Prot: CNN3_HUMAN, Q15417
    Tissue specificity: Expressed in both non-smooth muscle tissues as well as smooth muscle tissues

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CNN3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for CNN3 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cnn31 , 5 calponin 3, acidic1, 5 90.07(n)1
    97.87(a)1
      3 (52.94 cM)5
    719941  NM_028044.21  NP_082320.11 
     1214265415 
    chicken
    (Gallus gallus)
    Aves CNN31 calponin 3, acidic 83.6(n)
    94.21(a)
      424485  XM_422326.4  XP_422326.3 
    lizard
    (Anolis carolinensis)
    Reptilia CNN36
    calponin 3, acidic
    87(a)
    1 ↔ 1
    4(89287734-89294314)
    African clawed frog
    (Xenopus laevis)
    Amphibia cnn3-prov2 calponin 3, acidic 79.59(n)    BC043808.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufe49h102 wufe49h10 77.22(n)   326931  BC053309.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Chd641 Chd64 49.07(n)
    39.44(a)
      38490  NM_139603.3  NP_647860.1 
    worm
    (Caenorhabditis elegans)
    Secernentea cpn-26
    Protein CPN-2 (cpn-2) mRNA, complete cds
    37(a)
    1 → many
    II(337339-339248) WBGene00000778
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SCP16
    Component of yeast cortical actin cytoskeleton, bi...
    26(a)
    1 → many
    XV(1026007-1026609) YOR367W


    ENSEMBL Gene Tree for CNN3 (if available)
    TreeFam Gene Tree for CNN3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CNN3 gene
    TAGLN22  TAGLN2  CNN12  TAGLN32  CNN22  
    14 SIMAP similar genes for CNN3 using alignment to 5 protein entries:     CNN3_HUMAN (see all proteins):
    CNN1    CNN2    KIAA0142    LMO7    TAGLN3    LIMCH1
    VAV2    TAGLN2    TAGLN    VAV3    LRCH3    LRCH4
    ARHGEF7    LRCH1

    Find genes that share paralogs with CNN3           About GenesLikeMe


    4 Pseudogenes.org Pseudogenes for CNN3
    PGOHUM00000242873 PGOHUM00000237161 PGOHUM00000243479 PGOHUM00000249740


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CNN3 (see all 587)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1389061531,2
    C--93516326(+) TTTCTA/GCATTT 1 -- us2k10--------
    rs12651681,2
    C,F,A,H--93516386(-) GTGGCA/CATGTC 1 -- us2k118Minor allele frequency- C:0.27NS EA NA WA CSA 1212
    rs1828409581,2
    --93516388(+) CATTGC/TCACTG 1 -- us2k10--------
    rs1416204421,2
    C--93516456(+) TCCTTC/GGTTTC 1 -- us2k10--------
    rs120981341,2
    C,F--95362162(+) GGCTGA/TCCTAG 1 -- int15Minor allele frequency- T:0.14NA WA 244
    rs1872676231,2
    --95362302(+) AATAAA/GCAAGG 1 -- int10--------
    rs1921021891,2
    --95362434(+) GTACCC/TAGGAA 1 -- int10--------
    rs1838263831,2
    --95362602(+) GAAAAC/GAGAGC 1 -- ut310--------
    rs1118242751,2
    F--95362882(+) CAATAT/AGCATG 1 -- ut311Minor allele frequency- A:0.50CSA 2
    rs1884217931,2
    --95362899(+) GTCTTC/GCATGT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for CNN3 (95362507 - 95392834 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for CNN3: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CNN3
    DNA2.0 Custom Variant and Variant Library Synthesis for CNN3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602374    OMIM disorders: --


    Find genes that share disorders with CNN3           About GenesLikeMe

    Genetic Association Database (GAD): CNN3
    Human Genome Epidemiology (HuGE) Navigator: CNN3 (1 document)

    Export disorders for CNN3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CNN3 gene, integrated from 10 sources (see all 30):
    (articles sorted by number of sources associating them with CNN3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and gene mapping of human basic and acidic calponins. (PubMed id 8526917)1, 2, 3 Maguchi M.... Hiwada K. (Biochem. Biophys. Res. Commun. 1995)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. An emerin &quot;proteome&quot;: purification of distinct emerin-containing complexes from HeLa cells suggests molecular basis for diverse roles including gene regulation, mRNA splicing, signaling, mechanosensing, and nuclear architecture. (PubMed id 17620012)1, 9 Holaska J.M. and Wilson K.L. (Biochemistry 2007)
    6. Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium. (PubMed id 23362303)1 Wu J.H....Mozaffarian D. (Circ Cardiovasc Genet 2013)
    7. The P-body component USP52/PAN2 is a novel regulator of HIF1A mRNA stability. (PubMed id 23398456)1 Bett J.S....Hay R.T. (Biochem. J. 2013)
    8. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    9. Increased expression of calponin-3 in epileptic patients and experimental rats. (PubMed id 22119193)1 Han Y....Chen G. (Exp. Neurol. 2012)
    10. Identification of VKORC1 interaction partners by split-ubiquitin system and coimmunoprecipitation. (PubMed id 21103663)1 Schaafhausen A....MA1ller C.R. (Thromb. Haemost. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1266 HGNC: 2157 AceView: CNN3 Ensembl:ENSG00000117519 euGenes: HUgn1266
    ECgene: CNN3 H-InvDB: CNN3

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CNN3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for CNN3 gene:
    Search GeneIP for patents involving CNN3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

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