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Aliases for CNN3 Gene

Aliases for CNN3 Gene

  • Calponin 3, Acidic 2 3
  • Calponin, Acidic Isoform 3 4
  • DJ639P13.2.2 (Acidic Calponin 3) 3
  • Calponin-3 3

External Ids for CNN3 Gene

Summaries for CNN3 Gene

Entrez Gene Summary for CNN3 Gene

  • This gene encodes a protein with a markedly acidic C terminus; the basic N-terminus is highly homologous to the N-terminus of a related gene, CNN1. Members of the CNN gene family all contain similar tandemly repeated motifs. This encoded protein is associated with the cytoskeleton but is not involved in contraction. [provided by RefSeq, Jul 2008]

GeneCards Summary for CNN3 Gene

CNN3 (Calponin 3, Acidic) is a Protein Coding gene. GO annotations related to this gene include actin binding and microtubule binding. An important paralog of this gene is TAGLN2.

UniProtKB/Swiss-Prot for CNN3 Gene

  • Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CNN3 Gene

Genomics for CNN3 Gene

Genomic Location for CNN3 Gene

Start:
94,896,949 bp from pter
End:
94,927,278 bp from pter
Size:
30,330 bases
Orientation:
Minus strand

Genomic View for CNN3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CNN3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CNN3 Gene

Regulatory Elements for CNN3 Gene

Proteins for CNN3 Gene

  • Protein details for CNN3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15417-CNN3_HUMAN
    Recommended name:
    Calponin-3
    Protein Accession:
    Q15417
    Secondary Accessions:
    • B4DFK6
    • B4DP09
    • F8WA86
    • Q6FHA7

    Protein attributes for CNN3 Gene

    Size:
    329 amino acids
    Molecular mass:
    36414 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CNN3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CNN3 Gene

Proteomics data for CNN3 Gene at MOPED

Post-translational modifications for CNN3 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys256

Other Protein References for CNN3 Gene

No data available for DME Specific Peptides for CNN3 Gene

Domains for CNN3 Gene

UniProtKB/Swiss-Prot:

CNN3_HUMAN
Domain:
  • Contains 1 CH (calponin-homology) domain.:
    • Q15417
Family:
  • Belongs to the calponin family.:
    • Q15417
Similarity:
  • Contains 3 calponin-like repeats.:
    • Q15417
genes like me logo Genes that share domains with CNN3: view

No data available for Gene Families for CNN3 Gene

Function for CNN3 Gene

Molecular function for CNN3 Gene

GENATLAS Biochemistry: calponin,acidic,36kDa,cytoskeletal protein,ubiquitously expressed in smooth muscle and non smooth muscle tissues,actin,calmodulin,tropomyosin binding,downregulated during dedifferentiation of vascular smooth muscle cell
UniProtKB/Swiss-Prot Function: Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity

Gene Ontology (GO) - Molecular Function for CNN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA --
GO:0005515 protein binding --
GO:0005516 calmodulin binding IEA --
genes like me logo Genes that share ontologies with CNN3: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for CNN3 Gene

Localization for CNN3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CNN3 Gene COMPARTMENTS Subcellular localization image for CNN3 gene
Compartment Confidence
cytosol 3
cytoskeleton 2
nucleus 2
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CNN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005925 focal adhesion IDA 21423176
GO:0015629 actin cytoskeleton IDA --
genes like me logo Genes that share ontologies with CNN3: view

Pathways for CNN3 Gene

SuperPathways for CNN3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CNN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030855 epithelial cell differentiation IEP 21492153
GO:0031032 actomyosin structure organization IEA --
genes like me logo Genes that share ontologies with CNN3: view

No data available for Pathways by source for CNN3 Gene

Transcripts for CNN3 Gene

Unigene Clusters for CNN3 Gene

Calponin 3, acidic:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CNN3 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b
SP1: - - - - - - -
SP2: - - - - -
SP3: -
SP4: -
SP5:
SP6:
SP7: - - - - -

Relevant External Links for CNN3 Gene

GeneLoc Exon Structure for
CNN3
ECgene alternative splicing isoforms for
CNN3

Expression for CNN3 Gene

mRNA expression in normal human tissues for CNN3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CNN3 Gene

SOURCE GeneReport for Unigene cluster for CNN3 Gene Hs.483454

mRNA Expression by UniProt/SwissProt for CNN3 Gene

Q15417-CNN3_HUMAN
Tissue specificity: Expressed in both non-smooth muscle tissues as well as smooth muscle tissues
genes like me logo Genes that share expressions with CNN3: view

Orthologs for CNN3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CNN3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CNN3 36
  • 99.8 (n)
  • 99.7 (a)
CNN3 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CNN3 36
  • 94.83 (n)
  • 99.39 (a)
CNN3 37
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CNN3 36
  • 91.53 (n)
  • 98.07 (a)
CNN3 37
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cnn3 36
  • 90.07 (n)
  • 97.87 (a)
Cnn3 16
Cnn3 37
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CNN3 37
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CNN3 37
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cnn3 36
  • 90.07 (n)
  • 97.57 (a)
chicken
(Gallus gallus)
Aves CNN3 36
  • 83.6 (n)
  • 94.21 (a)
CNN3 37
  • 94 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CNN3 37
  • 87 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia cnn3-prov 36
tropical clawed frog
(Silurana tropicalis)
Amphibia cnn3 36
  • 79.13 (n)
  • 88.45 (a)
MGC76140 36
zebrafish
(Danio rerio)
Actinopterygii cnn3a 36
  • 74.92 (n)
  • 83.79 (a)
cnn3b 37
  • 81 (a)
ManyToMany
wufe49h10 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001313 36
  • 47.51 (n)
  • 40.88 (a)
fruit fly
(Drosophila melanogaster)
Insecta Chd64 36
  • 49.07 (n)
  • 39.44 (a)
Mp20 37
  • 37 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea cpn-2 37
  • 37 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SCP1 37
  • 26 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7148 37
  • 44 (a)
OneToMany
Species with no ortholog for CNN3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CNN3 Gene

ENSEMBL:
Gene Tree for CNN3 (if available)
TreeFam:
Gene Tree for CNN3 (if available)

Paralogs for CNN3 Gene

Paralogs for CNN3 Gene

Selected SIMAP similar genes for CNN3 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for CNN3 Gene

genes like me logo Genes that share paralogs with CNN3: view

Variants for CNN3 Gene

Sequence variations from dbSNP and Humsavar for CNN3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs10803 -- 94,897,723(-) GAGCT(C/T)AGTAT utr-variant-3-prime
rs859040 -- 94,919,114(+) GCAAA(G/T)AATGC intron-variant
rs859041 -- 94,918,519(+) aaaaa(A/C)aGTCG intron-variant
rs859042 -- 94,918,041(+) AGTCT(C/T)AGCAC intron-variant
rs859043 -- 94,915,952(+) TTCCC(A/G)CTGAC intron-variant

Relevant External Links for CNN3 Gene

HapMap Linkage Disequilibrium report
CNN3

No data available for Structural Variations from Database of Genomic Variants (DGV) for CNN3 Gene

Disorders for CNN3 Gene

Relevant External Links for CNN3

Genetic Association Database (GAD)
CNN3
Human Genome Epidemiology (HuGE) Navigator
CNN3
genes like me logo Genes that share disorders with CNN3: view

No data available for UniProtKB/Swiss-Prot for CNN3 Gene

Publications for CNN3 Gene

  1. Molecular cloning and gene mapping of human basic and acidic calponins. (PMID: 8526917) Maguchi M. … Hiwada K. (Biochem. Biophys. Res. Commun. 1995) 2 3 4
  2. An emerin "proteome": purification of distinct emerin-containing complexes from HeLa cells suggests molecular basis for diverse roles including gene regulation, mRNA splicing, signaling, mechanosensing, and nuclear architecture. (PMID: 17620012) Holaska J.M. … Wilson K.L. (Biochemistry 2007) 3 23
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 49

Products for CNN3 Gene

Sources for CNN3 Gene

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