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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CNN3 Gene

protein-coding   GIFtS: 53
GCID: GC01M095362

Calponin 3, Acidic

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Calponin 3, Acidic1 2
Calponin, Acidic Isoform2 3
calponin-32
DJ639P13.2.2 (Acidic Calponin 3)2

External Ids:    HGNC: 21571   Entrez Gene: 12662   Ensembl: ENSG000001175197   OMIM: 6023745   UniProtKB: Q154173   

Export aliases for CNN3 gene to outside databases

Previous GC identifers: GC01M095763 GC01M094568 GC01M094713 GC01M094834 GC01M095074 GC01M095135 GC01M093484


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CNN3 Gene:
This gene encodes a protein with a markedly acidic C terminus; the basic N-terminus is highly homologous to the
N-terminus of a related gene, CNN1. Members of the CNN gene family all contain similar tandemly repeated motifs.
This encoded protein is associated with the cytoskeleton but is not involved in contraction. (provided by RefSeq,
Jul 2008)

GeneCards Summary for CNN3 Gene: 
CNN3 (calponin 3, acidic) is a protein-coding gene. Diseases associated with CNN3 include aortic aneurysm, and neuronitis. GO annotations related to this gene include microtubule binding and actin binding. An important paralog of this gene is TAGLN2.

UniProtKB/Swiss-Prot: CNN3_HUMAN, Q15417
Function: Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle
contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of
calponin with actin inhibits the actomyosin Mg-ATPase activity




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_032977.9  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CNN3 gene promoter:
         ER-alpha   Pax-5   AML1a   p53   AP-4   Nkx2-5   XBP-1   C/EBPalpha   c-Myb   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCNN3 promoter sequence
   Search SABiosciences Chromatin IP Primers for CNN3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CNN3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p22-p21   Ensembl cytogenetic band:  1p21.3   HGNC cytogenetic band: 1p22-p21

CNN3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CNN3 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M095362:  view genomic region     (about GC identifiers)

Start:
95,362,507 bp from pter      End:
95,392,834 bp from pter
Size:
30,328 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CNN3_HUMAN, Q15417 (See protein sequence)
Recommended Name: Calponin-3  
Size: 329 amino acids; 36414 Da
Secondary accessions: Q6FHA7

Explore the universe of human proteins at neXtProt for CNN3: NX_Q15417

Explore proteomics data for CNN3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q15417

  • CNN3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CNN3 Protein Expression
    REFSEQ proteins: NP_001830.1  
    ENSEMBL proteins: 
     ENSP00000359225   ENSP00000401452   ENSP00000437665   ENSP00000377752   ENSP00000440081  

    Human Recombinant Protein Products for CNN3: 
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    OriGene Protein Over-expression Lysate for CNN3
    OriGene MassSpec for CNN3 
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    GenScript Custom Purified and Recombinant Proteins Services for CNN3
    Novus Biologicals CNN3 Proteins
    Novus Biologicals CNN3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CNN3 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0014069postsynaptic density IEA--
    GO:0030425dendrite ----
    GO:0043025neuronal cell body IEA--
    GO:0043197dendritic spine IEA--

    CNN3 for ontologies           About GeneDecksing



    CNN3 Antibody Products: 
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    Novus Biologicals CNN3 Antibodies
    Abcam antibodies for CNN3
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    ThermoFisher Antibody for CNN3
    LSBio Antibodies in human, mouse, rat for CNN3 

    Assay Products for CNN3: 
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    Cloud-Clone Corp. ELISAs for CNN3 
    Cloud-Clone Corp. CLIAs for CNN3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR001997 Calponin
     IPR001715 CH-domain
     IPR003096 SM22_calponin
     IPR000557 Calponin_repeat

    Graphical View of Domain Structure for InterPro Entry Q15417

    ProtoNet protein and cluster: Q15417

    3 Blocks protein domains:
    IPB001715 Calponin-like actin-binding
    IPB001997 Calponin signature
    IPB003247 Calponin-like actin-binding subtype


    UniProtKB/Swiss-Prot: CNN3_HUMAN, Q15417
    Similarity: Belongs to the calponin family
    Similarity: Contains 3 calponin-like repeats
    Similarity: Contains 1 CH (calponin-homology) domain


    CNN3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CNN3_HUMAN, Q15417
    Function: Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle
    contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of
    calponin with actin inhibits the actomyosin Mg-ATPase activity

         Genatlas biochemistry entry for CNN3:
    calponin,acidic,36kDa,cytoskeletal protein,ubiquitously expressed in smooth muscle and non smooth muscle
    tissues,actin,calmodulin,tropomyosin binding,downregulated during dedifferentiation of vascular smooth muscle
    cell

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding NAS--
    GO:0005515protein binding ----
    GO:0005516calmodulin binding NAS--
    GO:0005523tropomyosin binding NAS--
    GO:0008017microtubule binding IEA--
         
    CNN3 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for CNN3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CNN3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CNN3 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CNN3 

    miRNA
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    miRTarBase miRNAs that target CNN3:
    hsa-mir-1 (MIRT003526), hsa-mir-7 (MIRT004059)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CNN3
    8/33 QIAGEN miScript miRNA Assays for microRNAs that regulate CNN3 (see all 33):
    hsa-miR-3607-3p hsa-miR-429 hsa-miR-513a-5p hsa-miR-128 hsa-miR-16-1* hsa-miR-508-3p hsa-miR-124 hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmidCNN3 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of CNN3

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for CNN3 (see all 7)
    OriGene ORF clones in mouse, rat for CNN3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CNN3 (NM_001839)
    Sino Biological Human cDNA Clone for CNN3
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CNN3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CNN3
    Sirion Biotech Customized lentivirus for stable overexpression of CNN3 
                         Customized lentivirus expression plasmids for stable overexpression of CNN3 

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    Search LifeMap BioReagents cell lines for CNN3
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CNN3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CNN3

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5/15 Interacting proteins for CNN3 (Q154173 ENSP000003592254) via UniProtKB, MINT, STRING, and/or I2D (see all 15)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FYNP062413, ENSP000003576564I2D: score=2 STRING: ENSP00000357656
    SLX4Q8IY923, ENSP000002940084I2D: score=1 STRING: ENSP00000294008
    ATG5Q9H1Y03, ENSP000003433134I2D: score=1 STRING: ENSP00000343313
    LCP1P137963, ENSP000003157574I2D: score=5 STRING: ENSP00000315757
    EMDP504023I2D: score=2 
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006939smooth muscle contraction NAS--
    GO:0031032actomyosin structure organization IEA--
    GO:0032780negative regulation of ATPase activity IEA--

    CNN3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CNN3

    Search CenterWatch for drugs/clinical trials and news about CNN3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CNN3 gene: 
    NM_001839.3  

    Unigene Cluster for CNN3:

    Calponin 3, acidic
    Hs.483454  [show with all ESTs]
    Unigene Representative Sequence: NM_001839
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000370206(uc010otv.2 uc001dqz.4 uc010otx.2) ENST00000461018
    ENST00000487539 ENST00000415017 ENST00000474409 ENST00000538964 ENST00000394202
    ENST00000545882
    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CNN3
    8/33 QIAGEN miScript miRNA Assays for microRNAs that regulate CNN3 (see all 33):
    hsa-miR-3607-3p hsa-miR-429 hsa-miR-513a-5p hsa-miR-128 hsa-miR-16-1* hsa-miR-508-3p hsa-miR-124 hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmidCNN3 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CNN3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CNN3
    Clone
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    OriGene clones in human, mouse for CNN3 (see all 7)
    OriGene ORF clones in mouse, rat for CNN3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CNN3 (NM_001839)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CNN3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CNN3
    Sirion Biotech Customized lentivirus for stable overexpression of CNN3 
                         Customized lentivirus expression plasmids for stable overexpression of CNN3 
    Primer
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    OriGene qPCR primer pairs and template standards for CNN3
    OriGene qSTAR qPCR primer pairs in human, mouse for CNN3
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat CNN3
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CNN3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CNN3

    Additional mRNA sequence: 

    AK294141.1 AK298145.1 AK312370.1 AK316398.1 BC025372.2 CR541848.1 S80562.1 

    18 DOTS entries:

    DT.91707091  DT.95260960  DT.100038228  DT.100828373  DT.40106743  DT.100828369  DT.100828372  DT.91882574 
    DT.100828370  DT.100038227  DT.100828377  DT.100828378  DT.121389516  DT.121389546  DT.431783  DT.443895 
    DT.91807008  DT.95260941 

    24/407 AceView cDNA sequences (see all 407):

    AI150692 AA599581 BM904930 CB215038 AW629623 BI552687 NM_001839 CR541848 
    BX377430 BX418686 AW150149 CD519313 BM696718 BE531300 BM699310 BU146152 
    BX458262 BX458281 BU150139 BG056965 AI701207 BM669529 BP352256 BE298662 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for CNN3 (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b
    SP1:              -     -     -     -     -           -                 -                                 
    SP2:                          -     -     -           -                 -                                 
    SP3:                                                                    -                                 
    SP4:                                                  -                                                   
    SP5:                                                                                                      


    ECgene alternative splicing isoforms for CNN3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CNN3 expression in normal human tissues (normalized intensities)      CNN3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TACAAAAGTG
    CNN3 Expression
    About this image


    CNN3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/10 selected tissues (see all 10) fully expand
     
     Neural Crest (Gastrulation Derivatives)
             mesenchyme   
     
     Peripheral Nervous System (Nervous System)
             ganglia   
     
     Mesoderm (Gastrulation Derivatives)
             mesenchyme   
     
     Lower Urinary Tract (Urinary System)
             visceral organ   
     
     Heart (Cardiovascular System)
             mouse/organ system/cardiovascular system   

    See CNN3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CNN3

    SOURCE GeneReport for Unigene cluster: Hs.483454

    UniProtKB/Swiss-Prot: CNN3_HUMAN, Q15417
    Tissue specificity: Expressed in both non-smooth muscle tissues as well as smooth muscle tissues

        SABiosciences Custom PCR Arrays for CNN3
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CNN3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CNN3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for CNN3 gene from 8/17 species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cnn31 , 5 calponin 3, acidic1, 5 90.07(n)1
    97.87(a)1
      3 (52.94 cM)5
    719941  NM_028044.21  NP_082320.11 
     1214265415 
    chicken
    (Gallus gallus)
    Aves CNN31 calponin 3, acidic 81.54(n)
    91.38(a)
      424485  XM_422326.3  XP_422326.2 
    lizard
    (Anolis carolinensis)
    Reptilia CNN36
    Uncharacterized protein
    87(a)
    1 ↔ 1
    4(89287734-89294314)
    African clawed frog
    (Xenopus laevis)
    Amphibia cnn3-prov2 calponin 3, acidic 79.59(n)    BC043808.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufe49h102 wufe49h10 77.22(n)   326931  BC053309.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Mp201 Muscle protein 20 48.02(n)
    38.42(a)
      36468  NM_001014522.1  NP_001014522.1 
    worm
    (Caenorhabditis elegans)
    Secernentea cpn-26
    cpn-16
    (see all 4)
    Protein CPN-1
    (see all 4)
    35(a)
    34(a)
    (see all 4)
    1 ↔ many
    possible ortholog
    (see all 4)
    II(337339-339248)
    I(8636120-8637961)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SCP16
    Component of yeast cortical actin cytoskeleton, bi...
    25(a)
    1 → many
    XV(1026007-1026609)


    ENSEMBL Gene Tree for CNN3 (if available)
    TreeFam Gene Tree for CNN3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CNN3 gene
    TAGLN22  TAGLN2  CNN12  TAGLN32  CNN22  
    14 SIMAP similar genes for CNN3 using alignment to 5 protein entries:     CNN3_HUMAN (see all proteins):
    CNN1    CNN2    KIAA0142    LMO7    TAGLN3    LIMCH1
    VAV2    TAGLN2    TAGLN    VAV3    LRCH3    LRCH4
    ARHGEF7    LRCH1

    CNN3 for paralogs           About GeneDecksing


    4 Pseudogenes.org Pseudogenes for CNN3
    PGOHUM00000242873 PGOHUM00000237161 PGOHUM00000243479 PGOHUM00000249740


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/587 SNPs in CNN3 are shown (see all 587)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1389061531,2
    C--93516326(+) TTTCTA/GCATTT 1 -- us2k10--------
    rs12651681,2
    C,F,A,H--93516386(-) GTGGCA/CATGTC 1 -- us2k118Minor allele frequency- C:0.27NS EA NA WA CSA 1212
    rs1828409581,2
    --93516388(+) CATTGC/TCACTG 1 -- us2k10--------
    rs1416204421,2
    C--93516456(+) TCCTTC/GGTTTC 1 -- us2k10--------
    rs120981341,2
    C,F--95362162(+) GGCTGA/TCCTAG 1 -- int15Minor allele frequency- T:0.14NA WA 244
    rs1872676231,2
    --95362302(+) AATAAA/GCAAGG 1 -- int10--------
    rs1921021891,2
    --95362434(+) GTACCC/TAGGAA 1 -- int10--------
    rs1838263831,2
    --95362602(+) GAAAAC/GAGAGC 1 -- ut310--------
    rs1118242751,2
    F--95362882(+) CAATAT/AGCATG 1 -- ut311Minor allele frequency- A:0.50CSA 2
    rs1884217931,2
    --95362899(+) GTCTTC/GCATGT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for CNN3 (95362507 - 95392834 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for CNN3: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CNN3
    DNA2.0 Custom Variant and Variant Library Synthesis for CNN3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602374    OMIM disorders: --

    2 diseases for CNN3:    About MalaCards
    aortic aneurysm    neuronitis


    CNN3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): CNN3
    Human Genome Epidemiology (HuGE) Navigator: CNN3 (1 document)

    Export disorders for CNN3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CNN3 gene, integrated from 9 sources (see all 29):
    (articles sorted by number of sources associating them with CNN3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and gene mapping of human basic and acidic calponins. (PubMed id 8526917)1, 2, 3 Maguchi M.... Hiwada K. (1995)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    3. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. An emerin 'proteome': purification of distinct emerin-containing complexes from HeLa cells suggests molecular basis for diverse roles including gene regulation, mRNA splicing, signaling, mechanosensing, and nuclear architecture. (PubMed id 17620012)1, 9 Holaska J.M. and Wilson K.L. (2007)
    6. Genome-wide association study identifies novel loci as sociated with concentrations of four plasma phospholipid fatty acids in the de n ovo lipogenesis pathway: results from the Cohorts for Heart and Aging Research i n Genomic Epidemiology (CHARGE) consortium. (PubMed id 23362303)1 Wu J.H....Mozaffarian D. (2013)
    7. The P-body component USP52/PAN2 is a novel regulator o f HIF1A mRNA stability. (PubMed id 23398456)1 Bett J.S....Hay R.T. (2013)
    8. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)
    9. Increased expression of calponin-3 in epileptic patien ts and experimental rats. (PubMed id 22119193)1 Han Y....Chen G. (2012)
    10. Identification of VKORC1 interaction partners by spli t-ubiquitin system and coimmunoprecipitation. (PubMed id 21103663)1 Schaafhausen A....MA1ller C.R. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1266 HGNC: 2157 AceView: CNN3 Ensembl:ENSG00000117519 euGenes: HUgn1266
    ECgene: CNN3 H-InvDB: CNN3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CNN3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CNN3 gene:
    Search GeneIP for patents involving CNN3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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