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Aliases for CNN2 Gene

Aliases for CNN2 Gene

  • Calponin 2 2 3 5
  • Calponin H2, Smooth Muscle 3 4
  • Neutral Calponin 3 4
  • Calponin-2 3

External Ids for CNN2 Gene

Previous GeneCards Identifiers for CNN2 Gene

  • GC19P001102
  • GC19P000966
  • GC19P000977
  • GC19P000799

Summaries for CNN2 Gene

Entrez Gene Summary for CNN2 Gene

  • The protein encoded by this gene, which can bind actin, calmodulin, troponin C, and tropomyosin, may function in the structural organization of actin filaments. The encoded protein could play a role in smooth muscle contraction and cell adhesion. Several pseudogenes of this gene have been identified, and are present on chromosomes 1, 2, 3, 6, 9, 11, 13, 15, 16, 21 and 22. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2015]

GeneCards Summary for CNN2 Gene

CNN2 (Calponin 2) is a Protein Coding gene. Among its related pathways are Immune System and Myometrial Relaxation and Contraction Pathways. GO annotations related to this gene include actin binding and calmodulin binding. An important paralog of this gene is CNN3.

UniProtKB/Swiss-Prot for CNN2 Gene

  • Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CNN2 Gene

Genomics for CNN2 Gene

Regulatory Elements for CNN2 Gene

Enhancers for CNN2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F001025 1.5 FANTOM5 ENCODE 15.2 +2.1 2106 5.8 PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF143 SP3 NFYC ABCA7 CNN2 C19orf24 ARHGAP45 SCAMP4 GRIN3B SBNO2 GZMM R3HDM4 RNU6-2
GH19F001019 1.2 ENCODE 14.6 -5.1 -5068 4.4 MLX CREB3L1 ZFP64 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 ZNF263 SP3 LOC100288123 TMEM259 ENSG00000267317 GRIN3B MIER2 ABCA7 ENSG00000261526 CIRBP WDR18 ENSG00000266990
GH19F001014 1.3 FANTOM5 ENCODE 10.6 -9.4 -9430 3.9 HDGF PKNOX1 ZFP64 ZNF2 GLIS2 GATA2 KLF7 FOS ZNF263 SP3 ABCA7 GRIN3B ENSG00000266990 RNA5SP462 TMEM259 ENSG00000267317 LOC100288123 C19orf24 SCAMP4 CNN2
GH19F000931 1.7 FANTOM5 Ensembl ENCODE 4.9 -92.5 -92502 4.1 HDGF MLX ZFP64 ARID4B SIN3A DMAP1 ZNF48 YY1 SLC30A9 ZNF121 WDR18 CNN2 R3HDM4 MIDN CIRBP ENSG00000267159 GC19M000929
GH19F001037 1.2 ENCODE 6.9 +14.2 14161 6.0 HDGF PKNOX1 ARNT WRNIP1 ARID4B SIN3A YY1 SLC30A9 ZNF766 ZNF207 ABCA7 LOC100288123 TMEM259 GRIN3B ENSG00000267317 CIRBP ARHGAP45 POLRMT MIER2 CNN2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CNN2 on UCSC Golden Path with GeneCards custom track

Promoters for CNN2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001417251 1125 3201 PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF143 SP3 NFYC

Genomic Location for CNN2 Gene

Chromosome:
19
Start:
1,026,275 bp from pter
End:
1,039,068 bp from pter
Size:
12,794 bases
Orientation:
Plus strand

Genomic View for CNN2 Gene

Genes around CNN2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CNN2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CNN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CNN2 Gene

Proteins for CNN2 Gene

  • Protein details for CNN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99439-CNN2_HUMAN
    Recommended name:
    Calponin-2
    Protein Accession:
    Q99439
    Secondary Accessions:
    • A5D8U8
    • A6NFI4
    • D6W5X9
    • Q92578

    Protein attributes for CNN2 Gene

    Size:
    309 amino acids
    Molecular mass:
    33697 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CNN2 Gene

    Alternative splice isoforms for CNN2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CNN2 Gene

Post-translational modifications for CNN2 Gene

  • Ubiquitination at Lys 19, Lys 25, Lys 55, Lys 160, and Lys 174
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CNN2 Gene

Domains & Families for CNN2 Gene

Graphical View of Domain Structure for InterPro Entry

Q99439

UniProtKB/Swiss-Prot:

CNN2_HUMAN :
  • Contains 1 CH (calponin-homology) domain.
  • Belongs to the calponin family.
  • Contains 3 calponin-like repeats.
Domain:
  • Contains 1 CH (calponin-homology) domain.
Family:
  • Belongs to the calponin family.
Similarity:
  • Contains 3 calponin-like repeats.
genes like me logo Genes that share domains with CNN2: view

No data available for Gene Families for CNN2 Gene

Function for CNN2 Gene

Molecular function for CNN2 Gene

GENATLAS Biochemistry:
calponin neutral,h2,cytoskeletal protein of smooth muscle cells,actin,calmodulin,tropomyosin binding,closely related to non-muscle calponin CNN3
UniProtKB/Swiss-Prot Function:
Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity.

Gene Ontology (GO) - Molecular Function for CNN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA --
GO:0005516 calmodulin binding IEA --
GO:0098641 cadherin binding involved in cell-cell adhesion IDA 25468996
genes like me logo Genes that share ontologies with CNN2: view
genes like me logo Genes that share phenotypes with CNN2: view

Animal Models for CNN2 Gene

MGI Knock Outs for CNN2:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CNN2 Gene

Localization for CNN2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CNN2 gene
Compartment Confidence
extracellular 5
cytoskeleton 5
cytosol 4
nucleus 3
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CNN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001725 stress fiber IDA 16236705
GO:0005856 cytoskeleton IEA,TAS 8889829
GO:0005911 cell-cell junction TAS 8889829
GO:0005913 cell-cell adherens junction IDA 25468996
GO:0005925 focal adhesion IDA 21423176
genes like me logo Genes that share ontologies with CNN2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CNN2 Gene

Pathways & Interactions for CNN2 Gene

genes like me logo Genes that share pathways with CNN2: view

Pathways by source for CNN2 Gene

1 BioSystems pathway for CNN2 Gene
2 Reactome pathways for CNN2 Gene

Gene Ontology (GO) - Biological Process for CNN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007010 cytoskeleton organization IEA,TAS 8889829
GO:0010628 positive regulation of gene expression IEA --
GO:0030097 hemopoiesis IEA --
GO:0030336 negative regulation of cell migration IEA --
GO:0031032 actomyosin structure organization IEA --
genes like me logo Genes that share ontologies with CNN2: view

No data available for SIGNOR curated interactions for CNN2 Gene

Transcripts for CNN2 Gene

Unigene Clusters for CNN2 Gene

Calponin 2:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CNN2 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b
SP1: - -
SP2: - - -
SP3: - - -
SP4: -
SP5: -

Relevant External Links for CNN2 Gene

GeneLoc Exon Structure for
CNN2
ECgene alternative splicing isoforms for
CNN2

Expression for CNN2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CNN2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CNN2 Gene

This gene is overexpressed in Whole Blood (x12.5).

Protein differential expression in normal tissues from HIPED for CNN2 Gene

This gene is overexpressed in Bone marrow stromal cell (8.8), Platelet (8.3), and Lymph node (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CNN2 Gene



Protein tissue co-expression partners for CNN2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CNN2 Gene:

CNN2

SOURCE GeneReport for Unigene cluster for CNN2 Gene:

Hs.651512

mRNA Expression by UniProt/SwissProt for CNN2 Gene:

Q99439-CNN2_HUMAN
Tissue specificity: Heart and smooth muscle.
genes like me logo Genes that share expression patterns with CNN2: view

Orthologs for CNN2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CNN2 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia CNN2 34 35
  • 91.15 (n)
rat
(Rattus norvegicus)
Mammalia Cnn2 34
  • 90 (n)
oppossum
(Monodelphis domestica)
Mammalia CNN2 35
  • 90 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CNN2 34 35
  • 89 (n)
mouse
(Mus musculus)
Mammalia Cnn2 34 16 35
  • 88.85 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CNN2 35
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves CNN2 34 35
  • 80.7 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia cnn1 34
  • 73.12 (n)
Str.6304 34
African clawed frog
(Xenopus laevis)
Amphibia cnn2-prov 34
zebrafish
(Danio rerio)
Actinopterygii cnn2 34 35
  • 68.28 (n)
Dr.28235 34
fruit fly
(Drosophila melanogaster)
Insecta Mp20 34 35
  • 51.89 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012304 34
  • 51.41 (n)
worm
(Caenorhabditis elegans)
Secernentea cpn-2 35
  • 35 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SCP1 35
  • 27 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7148 35
  • 40 (a)
OneToMany
Species where no ortholog for CNN2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CNN2 Gene

ENSEMBL:
Gene Tree for CNN2 (if available)
TreeFam:
Gene Tree for CNN2 (if available)

Paralogs for CNN2 Gene

Paralogs for CNN2 Gene

genes like me logo Genes that share paralogs with CNN2: view

Variants for CNN2 Gene

Sequence variations from dbSNP and Humsavar for CNN2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10401325 -- 1,032,370(+) TCCCC(C/T)GCCCC intron-variant
rs10403470 -- 1,035,651(+) ggcgc(A/G)gtggc intron-variant
rs10406018 -- 1,025,570(+) tatta(A/T)taGGG upstream-variant-2KB
rs10407915 -- 1,035,456(+) CGCAG(A/C)CATCC intron-variant
rs10409682 -- 1,033,777(+) TAGAC(C/G)GGGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CNN2 Gene

Variant ID Type Subtype PubMed ID
nsv9662 CNV gain 18304495
nsv960770 CNV duplication 23825009
nsv953938 CNV deletion 24416366
nsv833704 CNV gain 17160897
nsv578188 CNV loss 21841781
nsv512556 CNV loss 21212237
nsv469845 CNV loss 16826518
nsv1160555 CNV deletion 26073780
nsv1143894 CNV deletion 24896259
esv3643383 CNV gain 21293372
esv3102679 CNV deletion 24192839
esv2758743 CNV gain+loss 17122850
esv2677837 CNV deletion 23128226
esv2586842 CNV deletion 19546169
esv25790 CNV loss 19812545
esv2492823 CNV deletion 19546169
esv22453 CNV loss 19812545
esv2044506 CNV deletion 18987734
esv1680853 CNV deletion 17803354
esv1006717 CNV loss 20482838
dgv487e201 CNV deletion 23290073
dgv486e201 CNV deletion 23290073
dgv136n111 CNV deletion 26073780
dgv135n111 CNV deletion 26073780

Variation tolerance for CNN2 Gene

Residual Variation Intolerance Score: 40.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.88; 18.31% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CNN2 Gene

Human Gene Mutation Database (HGMD)
CNN2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CNN2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CNN2 Gene

Disorders for CNN2 Gene

Relevant External Links for CNN2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CNN2

No disorders were found for CNN2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CNN2 Gene

Publications for CNN2 Gene

  1. Molecular cloning and characterization of human non-smooth muscle calponin. (PMID: 8889829) Masuda H. … Takahashi K. (J. Biochem. 1996) 2 3 4 22 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PMID: 12665801) Gevaert K. … Vandekerckhove J. (Nat. Biotechnol. 2003) 3 4 64
  4. A unique downregulation of h2-calponin gene expression in Down syndrome: a possible attenuation mechanism for fetal survival by methylation at the CpG island in the trisomic chromosome 21. (PMID: 9001224) Kuromitsu J. … Hayashizaki Y. (Mol. Cell. Biol. 1997) 3 4 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for CNN2 Gene

Sources for CNN2 Gene

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