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CNN2 Gene

protein-coding   GIFtS: 55
GCID: GC19P001026

Calponin 2

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Calponin 21 2
Calponin H2, Smooth Muscle2 3
Neutral Calponin2 3
calponin-22

External Ids:    HGNC: 21561   Entrez Gene: 12652   Ensembl: ENSG000000646667   OMIM: 6023735   UniProtKB: Q994393   

Export aliases for CNN2 gene to outside databases

Previous GC identifers: GC19P001102 GC19P000966 GC19P000977 GC19P000799


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CNN2 Gene:
The protein encoded by this gene, which can bind actin, calmodulin, troponin C, and tropomyosin, may function in
the structural organization of actin filaments. The encoded protein could play a role in smooth muscle
contraction and cell adhesion. Two transcript variants encoding different isoforms have been found for this gene.
(provided by RefSeq, Jul 2008)

GeneCards Summary for CNN2 Gene:
CNN2 (calponin 2) is a protein-coding gene. GO annotations related to this gene include actin binding and calmodulin binding. An important paralog of this gene is TAGLN2.

UniProtKB/Swiss-Prot: CNN2_HUMAN, Q99439
Function: Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle
contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of
calponin with actin inhibits the actomyosin Mg-ATPase activity




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NC_018930.2  NT_011295.12  
Regulatory elements:
   Regulatory transcription factor binding sites in the CNN2 gene promoter:
         Max1   NRSF form 1   Brachyury   NRSF form 2   AP-2gamma   COMP1   AP-2beta   AP-2alpha   c-Myc   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CNN2 promoter sequence
   Search Chromatin IP Primers for CNN2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CNN2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13.3

CNN2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CNN2 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P001026:  view genomic region     (about GC identifiers)

Start:
1,026,298 bp from pter      End:
1,039,068 bp from pter
Size:
12,771 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CNN2_HUMAN, Q99439 (See protein sequence)
Recommended Name: Calponin-2  
Size: 309 amino acids; 33697 Da
1 PDB 3D structure from and Proteopedia for CNN2:
1WYN (3D)    
Secondary accessions: A5D8U8 A6NFI4 D6W5X9 Q92578
Alternative splicing: 2 isoforms:  Q99439-1   Q99439-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CNN2: NX_Q99439

Explore proteomics data for CNN2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys8, Lys19, Lys25, Lys55, Lys160, Lys174
  • Modification sites at PhosphoSitePlus

  • See CNN2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_004359.1  NP_958434.1  

    ENSEMBL proteins: 
     ENSP00000263097   ENSP00000340129   ENSP00000457968   ENSP00000468577   ENSP00000456436  
     ENSP00000455777   ENSP00000475175   ENSP00000458137  

    CNN2 Human Recombinant Protein Products:

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    OriGene MassSpec for CNN2
    OriGene Custom Protein Services for CNN2
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    Novus Biologicals CNN2 Protein
    Novus Biologicals CNN2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CNN2

     
    Search eBioscience for Proteins for CNN2 

     
    antibodies-online proteins for CNN2 (4 products) 

     
    antibodies-online peptides for CNN2

    CNN2 Antibody Products:

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    antibodies-online antibodies for CNN2 (49 products) 

    CNN2 Assay Products:

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    Cloud-Clone Corp. ELISAs for CNN2
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    antibodies-online kits for CNN2 (10 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR001997 Calponin
     IPR001715 CH-domain
     IPR003096 SM22_calponin
     IPR000557 Calponin_repeat

    Graphical View of Domain Structure for InterPro Entry Q99439

    ProtoNet protein and cluster: Q99439

    3 Blocks protein domains:
    IPB001715 Calponin-like actin-binding
    IPB001997 Calponin signature
    IPB003247 Calponin-like actin-binding subtype


    UniProtKB/Swiss-Prot: CNN2_HUMAN, Q99439
    Similarity: Belongs to the calponin family
    Similarity: Contains 3 calponin-like repeats
    Similarity: Contains 1 CH (calponin-homology) domain


    Find genes that share domains with CNN2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CNN2_HUMAN, Q99439
    Function: Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle
    contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of
    calponin with actin inhibits the actomyosin Mg-ATPase activity

         Genatlas biochemistry entry for CNN2:
    calponin neutral,h2,cytoskeletal protein of smooth muscle cells,actin,calmodulin,tropomyosin binding,closely
    related to non-muscle calponin CNN3

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding IEA--
    GO:0005515protein binding ----
    GO:0005516calmodulin binding IEA--
         
    Find genes that share ontologies with CNN2           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for CNN2:
     High actin ratio cells 

         5 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Cnn2):
     cellular  hematopoietic system  homeostasis/metabolism  immune system  no phenotypic analysis 

    Find genes that share phenotypes with CNN2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Cnn2tm1.2Jin for CNN2

       genOway: Develop your customized and physiologically relevant rodent model for CNN2

    miRNA
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    miRTarBase miRNAs that target CNN2:
    hsa-mir-133a-3p (MIRT021704), hsa-mir-346 (MIRT042725), hsa-mir-744-5p (MIRT037661)

    Block miRNA regulation of human, mouse, rat CNN2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CNN2 (see all 9):
    hsa-miR-137 hsa-miR-130a* hsa-miR-133b hsa-miR-23c hsa-miR-23b hsa-miR-133a hsa-miR-23a hsa-miR-143*
    SwitchGear 3'UTR luciferase reporter plasmidCNN2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CNN2
    Predesigned siRNA for gene silencing in human, mouse, rat CNN2

    Gene Editing
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    Clone
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    OriGene ORF clones in mouse, rat for CNN2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CNN2 (NM_004368)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CNN2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CNN2

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for CNN2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CNN2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    cytosol3
    nucleus2
    extracellular1
    mitochondrion1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001725stress fiber IDA16236705
    GO:0005856cytoskeleton TAS8889829
    GO:0005911cell-cell junction TAS8889829

    Find genes that share ontologies with CNN2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CNN2 About    
    See pathways by source

    SuperPathContained pathways About
    1Myometrial Relaxation and Contraction Pathways
    Myometrial Relaxation and Contraction Pathways0.43


    1 BioSystems Pathway for CNN2
        Myometrial Relaxation and Contraction Pathways


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CNN2
    Interactions:

        Search GeneGlobe Interaction Network for CNN2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    Selected Interacting proteins for CNN2 (Q994393 ENSP000002630974) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ACTBP607093, ENSP000003499604I2D: score=1 STRING: ENSP00000349960
    UBCENSP000003448184STRING: ENSP00000344818
    COTL1ENSP000002624284STRING: ENSP00000262428
    CTTNENSP000003018434STRING: ENSP00000301843
    DBN1ENSP000002923854STRING: ENSP00000292385
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007010cytoskeleton organization TAS8889829
    GO:0010628positive regulation of gene expression IEA--
    GO:0030097hemopoiesis IEA--
    GO:0030336negative regulation of cell migration IEA--
    GO:0031032actomyosin structure organization IEA--

    Find genes that share ontologies with CNN2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CNN2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CNN2 gene (2 alternative transcripts): 
    NM_004368.2  NM_201277.1  

    Unigene Cluster for CNN2:

    Calponin 2
    Hs.651512  [show with all ESTs]
    Unigene Representative Sequence: NM_004368
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000263097 ENST00000562015 ENST00000606983 ENST00000348419(uc002lqu.3 uc002lqv.3 uc010xgb.2 uc010xgc.2)
    ENST00000565096 ENST00000569352 ENST00000562958 ENST00000562075(uc002lqt.1 uc010drz.1)
    ENST00000607102 ENST00000566695 ENST00000568865 ENST00000564572
    miRNA
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    Block miRNA regulation of human, mouse, rat CNN2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CNN2 (see all 9):
    hsa-miR-137 hsa-miR-130a* hsa-miR-133b hsa-miR-23c hsa-miR-23b hsa-miR-133a hsa-miR-23a hsa-miR-143*
    SwitchGear 3'UTR luciferase reporter plasmidCNN2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CNN2
    Predesigned siRNA for gene silencing in human, mouse, rat CNN2
    Clone
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    OriGene ORF clones in mouse, rat for CNN2
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    GenScript: all cDNA clones in your preferred vector (see all 2): CNN2 (NM_004368)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CNN2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CNN2
    Primer
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    OriGene qPCR primer pairs and template standards for CNN2
    OriGene qSTAR qPCR primer pairs in human, mouse for CNN2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CNN2
      QuantiTect SYBR Green Assays in human, mouse, rat CNN2
      QuantiFast Probe-based Assays in human, mouse, rat CNN2

    Additional mRNA sequence: 

    AK024835.1 AK057960.1 AK126391.1 AK222924.1 AK293171.1 AK295271.1 AK297774.1 AK300788.1 
    AY927510.1 AY927514.1 BC141818.1 BC141833.1 BC148264.1 CR541810.1 CR541831.1 D83735.1 
    D86059.1 

    Selected DOTS entries (see all 42):

    DT.92452188  DT.100888912  DT.95372006  DT.100765294  DT.95332015  DT.95372004  DT.95071699  DT.100696096 
    DT.95371979  DT.100888937  DT.100888950  DT.100888951  DT.100766100  DT.121502280  DT.121502267  DT.121502259 
    DT.100696720  DT.95076658  DT.100753847  DT.100688095  DT.100841523  DT.100888919  DT.100888920  DT.95372005 

    21 AceView cDNA sequences:

    CR615042 CR592088 CR592852 CR602855 CR616871 CR611249 CR598250 CR606476 
    CR618608 CR603928 CR607371 NM_201277 CR541831 AK024835 AK057960 AK093630 
    D83735 CR541810 NM_004368 D86059 X05126 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for CNN2    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b
    SP1:        -                             -                           
    SP2:        -                             -     -                     
    SP3:        -                       -     -                           
    SP4:                                      -                           
    SP5:        -                                                         


    ECgene alternative splicing isoforms for CNN2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CNN2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCCCGCCAAG
    CNN2 Expression
    About this image


    CNN2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 11) fully expand
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Heart (Cardiovascular System)
             Heart Tube
     
     Epiblast (Early Embryonic Tissues)
             Epiblast Stem Cell line 5
     
     Uterus (Reproductive System)
     
     Lung (Respiratory System)
    CNN2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CNN2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.651512

    UniProtKB/Swiss-Prot: CNN2_HUMAN, Q99439
    Tissue specificity: Heart and smooth muscle

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    QuantiFast Probe-based Assays in human, mouse, rat CNN2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CNN2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for CNN2 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cnn21 , 5 calponin 21, 5 88.85(n)1
    96.07(a)1
      10 (39.72 cM)5
    127981  NM_007725.21  NP_031751.11 
     799885845 
    chicken
    (Gallus gallus)
    Aves CNN21 calponin 2 80.7(n)
    85.86(a)
      100216000  NM_001142256.1  NP_001135728.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia cnn2-prov2 calponin 2 80.48(n)    BC046257.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.282352 Danio rerio cDNA clone MGC65794 IMAGE6791200, complete more 74.97(n)    BC059802.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Mp201 Muscle protein 20 51.89(n)
    36.36(a)
      36468  NM_057295.4  NP_476643.1 
    worm
    (Caenorhabditis elegans)
    Secernentea cpn-26
    Protein CPN-2 (cpn-2) mRNA, complete cds
    35(a)
    1 → many
    II(337339-339248) WBGene00000778
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SCP16
    Component of yeast cortical actin cytoskeleton, bi...
    27(a)
    1 → many
    XV(1026007-1026609) YOR367W


    ENSEMBL Gene Tree for CNN2 (if available)
    TreeFam Gene Tree for CNN2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CNN2 gene
    TAGLN22  TAGLN2  CNN12  CNN32  TAGLN32  
    Selected SIMAP similar genes for CNN2 using alignment to 9 protein entries:     CNN2_HUMAN (see all proteins) (see all similar genes):
    RHBG    NLN    TNNT1    SEC14L3    COQ5    RRM2B
    RBMS2    CNN3    MST132    ZNF799    CNN1    ZNF429
    DPP9    RQCD1    VPS33A    PFKFB3    ZNF114    ACTR10

    Find genes that share paralogs with CNN2           About GenesLikeMe


    Selected Pseudogenes.org Pseudogenes for CNN2 (see all 21)
    PGOHUM00000242544 PGOHUM00000262204 PGOHUM00000246798 PGOHUM00000248916 PGOHUM00000245068


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CNN2 (see all 454)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1811289111,2
    --1024316(+) AGCCCG/TGCCAC 2 -- us2k10--------
    rs2020531551,2
    --1024419(+) TGAAA-/CCCGCA 2 -- us2k10--------
    rs1427698881,2
    C--1024474(+) TCTACA/GGTCCC 2 -- us2k10--------
    rs1449858291,2
    --1024477(+) ACGGTC/TCCAGC 2 -- us2k10--------
    rs1869843161,2
    --1024659(+) ATCACC/GAGGTC 2 -- us2k10--------
    rs1914668521,2
    --1024673(+) AGATCG/TAGACC 2 -- us2k10--------
    rs1834450871,2
    --1024731(+) TTAGCC/TGGGTG 2 -- us2k10--------
    rs129862791,2
    C,F--1024824(+) gccaaG/Cattgc 2 -- us2k1 tfbs32Minor allele frequency- C:0.50NA 4
    rs1145557121,2
    F--1024909(+) CATGAA/GGTATT 2 -- us2k11Minor allele frequency- G:0.16WA 118
    rs1865369861,2
    --1024947(+) TCCAGC/TGCTCA 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for CNN2 (1026298 - 1039068 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for CNN2 (see all 35):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2677837CNV Deletion23128226
    dgv528e201CNV Deletion23290073
    dgv527e201CNV Deletion23290073
    esv2586842CNV Deletion19546169
    esv1680853CNV Deletion17803354
    esv2492823CNV Deletion19546169
    esv2044506CNV Deletion18987734
    nsv910384CNV Loss21882294
    dgv3575n71CNV Loss21882294
    nsv910310CNV Loss21882294

    Human Gene Mutation Database (HGMD): CNN2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CNN2
    DNA2.0 Custom Variant and Variant Library Synthesis for CNN2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602373    OMIM disorders: --


    Find genes that share disorders with CNN2           About GenesLikeMe


    Export disorders for CNN2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CNN2 gene, integrated from 10 sources (see all 34):
    (articles sorted by number of sources associating them with CNN2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and characterization of human non-smooth muscle calponin. (PubMed id 8889829)1, 2, 3, 9 Masuda H....Takahashi K. (J. Biochem. 1996)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (Nat. Biotechnol. 2003)
    4. A unique downregulation of h2-calponin gene expression in Down syndrome: a possible attenuation mechanism for fetal survival by methylation at the CpG island in the trisomic chromosome 21. (PubMed id 9001224)1, 2 Kuromitsu J.... Hayashizaki Y. (Mol. Cell. Biol. 1997)
    5. Mechanoregulation of h2-calponin gene expression and the role of Notch signaling. (PubMed id 24285540)1 Jiang W.R....Jin J.P. (J. Biol. Chem. 2014)
    6. The intracellular interactome of tetraspanin-enriched microdomains reveals their function as sorting machineries toward exosomes. (PubMed id 23463506)1 Perez-Hernandez D....YA!A+ez-MA^ M. (J. Biol. Chem. 2013)
    7. The P-body component USP52/PAN2 is a novel regulator of HIF1A mRNA stability. (PubMed id 23398456)1 Bett J.S....Hay R.T. (Biochem. J. 2013)
    8. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    9. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    10. A high-throughput approach for measuring temporal changes in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (Nat. Methods 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1265 HGNC: 2156 AceView: CNN2 Ensembl:ENSG00000064666 euGenes: HUgn1265
    ECgene: CNN2 H-InvDB: CNN2

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CNN2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for CNN2 gene:
    Search GeneIP for patents involving CNN2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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