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Aliases for CNN2 Gene

Aliases for CNN2 Gene

  • Calponin 2 2 3
  • Calponin H2, Smooth Muscle 3 4
  • Neutral Calponin 3 4
  • Calponin-2 3

External Ids for CNN2 Gene

Previous GeneCards Identifiers for CNN2 Gene

  • GC19P001102
  • GC19P000966
  • GC19P000977
  • GC19P000799

Summaries for CNN2 Gene

Entrez Gene Summary for CNN2 Gene

  • The protein encoded by this gene, which can bind actin, calmodulin, troponin C, and tropomyosin, may function in the structural organization of actin filaments. The encoded protein could play a role in smooth muscle contraction and cell adhesion. Several pseudogenes of this gene have been identified, and are present on chromosomes 1, 2, 3, 6, 9, 11, 13, 15, 16, 21 and 22. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2015]

GeneCards Summary for CNN2 Gene

CNN2 (Calponin 2) is a Protein Coding gene. Among its related pathways are Myometrial Relaxation and Contraction Pathways. GO annotations related to this gene include actin binding and calmodulin binding. An important paralog of this gene is CNN3.

UniProtKB/Swiss-Prot for CNN2 Gene

  • Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CNN2 Gene

Genomics for CNN2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CNN2 Gene

Start:
1,026,299 bp from pter
End:
1,039,068 bp from pter
Size:
12,770 bases
Orientation:
Plus strand

Genomic View for CNN2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CNN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CNN2 Gene

Proteins for CNN2 Gene

  • Protein details for CNN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99439-CNN2_HUMAN
    Recommended name:
    Calponin-2
    Protein Accession:
    Q99439
    Secondary Accessions:
    • A5D8U8
    • A6NFI4
    • D6W5X9
    • Q92578

    Protein attributes for CNN2 Gene

    Size:
    309 amino acids
    Molecular mass:
    33697 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CNN2 Gene

    Alternative splice isoforms for CNN2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CNN2 Gene

Proteomics data for CNN2 Gene at MOPED

Post-translational modifications for CNN2 Gene

  • Ubiquitination at Lys8, Lys19, Lys25, Lys55, Lys160, and Lys174
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for CNN2 Gene

Domains for CNN2 Gene

Graphical View of Domain Structure for InterPro Entry

Q99439

UniProtKB/Swiss-Prot:

CNN2_HUMAN :
  • Q99439
Domain:
  • Contains 1 CH (calponin-homology) domain.
Family:
  • Belongs to the calponin family.
Similarity:
  • Contains 3 calponin-like repeats.
genes like me logo Genes that share domains with CNN2: view

No data available for Gene Families for CNN2 Gene

Function for CNN2 Gene

Molecular function for CNN2 Gene

GENATLAS Biochemistry: calponin neutral,h2,cytoskeletal protein of smooth muscle cells,actin,calmodulin,tropomyosin binding,closely related to non-muscle calponin CNN3
UniProtKB/Swiss-Prot Function: Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity

Gene Ontology (GO) - Molecular Function for CNN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA --
GO:0005515 protein binding --
GO:0005516 calmodulin binding IEA --
genes like me logo Genes that share ontologies with CNN2: view
genes like me logo Genes that share phenotypes with CNN2: view

Animal Models for CNN2 Gene

MGI Knock Outs for CNN2:

Animal Model Products

miRNA for CNN2 Gene

miRTarBase miRNAs that target CNN2

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for CNN2 Gene

Localization for CNN2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CNN2 Gene COMPARTMENTS Subcellular localization image for CNN2 gene
Compartment Confidence
cytoskeleton 5
cytosol 3
nucleus 2
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CNN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001725 stress fiber IDA 16236705
GO:0005856 cytoskeleton TAS 8889829
GO:0005911 cell-cell junction TAS 8889829
GO:0005925 focal adhesion IDA 21423176
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with CNN2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CNN2 Gene

Pathways for CNN2 Gene

genes like me logo Genes that share pathways with CNN2: view

Pathways by source for CNN2 Gene

1 BioSystems pathway for CNN2 Gene

Gene Ontology (GO) - Biological Process for CNN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007010 cytoskeleton organization TAS 8889829
GO:0010628 positive regulation of gene expression IEA --
GO:0030097 hemopoiesis IEA --
GO:0030336 negative regulation of cell migration IEA --
GO:0031032 actomyosin structure organization IEA --
genes like me logo Genes that share ontologies with CNN2: view

Transcripts for CNN2 Gene

Unigene Clusters for CNN2 Gene

Calponin 2:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CNN2

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CNN2 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b
SP1: - -
SP2: - - -
SP3: - - -
SP4: -
SP5: -

Relevant External Links for CNN2 Gene

GeneLoc Exon Structure for
CNN2
ECgene alternative splicing isoforms for
CNN2

Expression for CNN2 Gene

mRNA expression in normal human tissues for CNN2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CNN2 Gene

This gene is overexpressed in Whole Blood (12.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CNN2 Gene

SOURCE GeneReport for Unigene cluster for CNN2 Gene Hs.651512

mRNA Expression by UniProt/SwissProt for CNN2 Gene

Q99439-CNN2_HUMAN
Tissue specificity: Heart and smooth muscle
genes like me logo Genes that share expressions with CNN2: view

In Situ Assay Products

Orthologs for CNN2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CNN2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CNN2 35
  • 89 (n)
  • 95.15 (a)
CNN2 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CNN2 35
  • 91.15 (n)
  • 94.5 (a)
CNN2 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cnn2 35
  • 88.85 (n)
  • 96.07 (a)
Cnn2 16
Cnn2 36
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CNN2 36
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CNN2 36
  • 82 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cnn2 35
  • 90 (n)
  • 98.64 (a)
chicken
(Gallus gallus)
Aves CNN2 35
  • 80.7 (n)
  • 85.86 (a)
CNN2 36
  • 84 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia cnn2-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia cnn1 35
  • 73.12 (n)
  • 84.95 (a)
Str.6304 35
zebrafish
(Danio rerio)
Actinopterygii cnn2 35
  • 68.28 (n)
  • 75.86 (a)
cnn2 36
  • 73 (a)
OneToOne
Dr.28235 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012304 35
  • 51.41 (n)
  • 37.85 (a)
fruit fly
(Drosophila melanogaster)
Insecta Mp20 35
  • 51.89 (n)
  • 36.36 (a)
Mp20 36
  • 33 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea cpn-2 36
  • 35 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SCP1 36
  • 27 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7148 36
  • 40 (a)
OneToMany
Species with no ortholog for CNN2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CNN2 Gene

ENSEMBL:
Gene Tree for CNN2 (if available)
TreeFam:
Gene Tree for CNN2 (if available)

Paralogs for CNN2 Gene

Paralogs for CNN2 Gene

genes like me logo Genes that share paralogs with CNN2: view

Variants for CNN2 Gene

Sequence variations from dbSNP and Humsavar for CNN2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs930231 -- 1,036,445(-) ATGCC(C/G/T)GACTG synonymous-codon, reference
rs930232 -- 1,036,019(-) CCTGC(C/T)GCGCA intron-variant
rs1064410 -- 1,036,457(+) ACTGC(C/G)TACGG reference, synonymous-codon
rs1064411 -- 1,036,469(+) ACGAG(A/G)AGGCA reference, synonymous-codon
rs1141534 -- 1,032,690(+) CTGGC(G/T)GGGAA reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for CNN2 Gene

Variant ID Type Subtype PubMed ID
dgv3513n71 CNV Loss 21882294
dgv3552n71 CNV Loss 21882294
nsv910292 CNV Loss 21882294
nsv910310 CNV Loss 21882294
dgv3555n71 CNV Loss 21882294
dgv3560n71 CNV Loss 21882294
nsv9662 CNV Gain 18304495
dgv3564n71 CNV Loss 21882294
dgv3566n71 CNV Loss 21882294
nsv469845 CNV Loss 16826518
essv258 CNV CNV 17122850
nsv833704 CNV Gain 17160897
dgv1055e1 CNV Complex 17122850
nsv910361 CNV Gain+Loss 21882294
dgv3567n71 CNV Loss 21882294
dgv3568n71 CNV Loss 21882294
dgv3569n71 CNV Loss 21882294
dgv3572n71 CNV Loss 21882294
nsv910383 CNV Gain 21882294
nsv910384 CNV Loss 21882294
dgv3574n71 CNV Loss 21882294
dgv3575n71 CNV Loss 21882294
nsv910388 CNV Gain 21882294
esv2586842 CNV Deletion 19546169
esv2044506 CNV Deletion 18987734
esv25790 CNV Loss 19812545
esv1006717 CNV Loss 20482838
esv2677837 CNV Deletion 23128226
nsv512556 CNV Loss 21212237
esv2492823 CNV Deletion 19546169
esv22453 CNV Loss 19812545
dgv527e201 CNV Deletion 23290073
dgv528e201 CNV Deletion 23290073
esv1680853 CNV Deletion 17803354
nsv910392 CNV Gain 21882294

Relevant External Links for CNN2 Gene

HapMap Linkage Disequilibrium report
CNN2
Human Gene Mutation Database (HGMD)
CNN2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CNN2 Gene

Disorders for CNN2 Gene

No disorders were found for CNN2 Gene.

No data available for UniProtKB/Swiss-Prot for CNN2 Gene

Publications for CNN2 Gene

  1. Molecular cloning and characterization of human non-smooth muscle calponin. (PMID: 8889829) Masuda H. … Takahashi K. (J. Biochem. 1996) 2 3 4 23
  2. A unique downregulation of h2-calponin gene expression in Down syndrome: a possible attenuation mechanism for fetal survival by methylation at the CpG island in the trisomic chromosome 21. (PMID: 9001224) Kuromitsu J. … Hayashizaki Y. (Mol. Cell. Biol. 1997) 3 4
  3. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PMID: 12665801) Gevaert K. … Vandekerckhove J. (Nat. Biotechnol. 2003) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. h2-Calponin is regulated by mechanical tension and modifies the function of actin cytoskeleton. (PMID: 16236705) Hossain M.M. … Jin J.P. (J. Biol. Chem. 2005) 3

Products for CNN2 Gene

Sources for CNN2 Gene

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