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Aliases for CNKSR3 Gene

Aliases for CNKSR3 Gene

  • CNKSR Family Member 3 2 3 4 5
  • Connector Enhancer Of KSR 3 3 4
  • CNK Homolog Protein 3 3 4
  • Maguin-Like Protein 3 4
  • MAGI1 3 4
  • CNK3 3 4
  • Membrane Associated Guanylate Kinase, WW And PDZ Domain Containing 1 3
  • Membrane Associated Guanylate Kinase Interacting Protein-Like 1 2
  • Membrane-Associated Guanylate Kinase-Interacting Protein-Like 1 3
  • Connector Enhancer Of Kinase Suppressor Of Ras 3 3

External Ids for CNKSR3 Gene

Previous HGNC Symbols for CNKSR3 Gene

  • MAGI1

Previous GeneCards Identifiers for CNKSR3 Gene

  • GC06M154819
  • GC06M152289
  • GC06M154708
  • GC06M154159

Summaries for CNKSR3 Gene

GeneCards Summary for CNKSR3 Gene

CNKSR3 (CNKSR Family Member 3) is a Protein Coding gene. GO annotations related to this gene include peroxidase activity and oxygen transporter activity. An important paralog of this gene is CNKSR2.

UniProtKB/Swiss-Prot for CNKSR3 Gene

  • Probably involved in transepithelial sodium transport. Regulates aldosterone-induced and ENaC-mediated sodium transport possibly through regulation of the ERK pathway (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CNKSR3 Gene

Genomics for CNKSR3 Gene

Regulatory Elements for CNKSR3 Gene

Enhancers for CNKSR3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06F154537 1 FANTOM5 ENCODE 50 -27.5 -27476 2.8 SOX13 ELF3 CEBPG RAD21 ZIC2 ZFHX2 ZBTB48 HNF4G CREM EGR2 CNKSR3 IPCEF1 ENSG00000275419
GH06F154592 1.5 FANTOM5 Ensembl ENCODE 22 -82.7 -82693 1.5 BCOR LEF1 PKNOX1 L3MBTL2 ARID1B JUND PBX2 IKZF1 ZNF547 CREM CNKSR3 RPL31P29 GC06P154578
GH06F154553 0.9 Ensembl ENCODE 21.1 -44.4 -44385 2.1 INSM2 KLF17 FEZF1 ZNF2 ZEB1 RFX5 ZNF121 ZNF366 SCRT2 ZNF391 CNKSR3 LOC100129996 RPS4XP8
GH06F154506 0.8 FANTOM5 ENCODE 16.1 +0.8 752 6.8 HDGF MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF263 SP3 CNKSR3 LOC101928868 LOC105378067
GH06F154536 0.2 ENCODE 12.6 -25.8 -25810 0.3 CNKSR3 ENSG00000275419
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around CNKSR3 on UCSC Golden Path with GeneCards custom track

Promoters for CNKSR3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001231279 659 4001 HDGF MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF263 SP3

Genomic Location for CNKSR3 Gene

Chromosome:
6
Start:
154,387,504 bp from pter
End:
154,510,659 bp from pter
Size:
123,156 bases
Orientation:
Minus strand

Genomic View for CNKSR3 Gene

Genes around CNKSR3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CNKSR3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CNKSR3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CNKSR3 Gene

Proteins for CNKSR3 Gene

  • Protein details for CNKSR3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6P9H4-CNKR3_HUMAN
    Recommended name:
    Connector enhancer of kinase suppressor of ras 3
    Protein Accession:
    Q6P9H4
    Secondary Accessions:
    • Q5SGD5
    • Q96N65

    Protein attributes for CNKSR3 Gene

    Size:
    555 amino acids
    Molecular mass:
    61904 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CNKSR3 Gene

Post-translational modifications for CNKSR3 Gene

  • Ubiquitination at Lys 305
  • Modification sites at PhosphoSitePlus

Other Protein References for CNKSR3 Gene

No data available for DME Specific Peptides for CNKSR3 Gene

Domains & Families for CNKSR3 Gene

Protein Domains for CNKSR3 Gene

Suggested Antigen Peptide Sequences for CNKSR3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6P9H4

UniProtKB/Swiss-Prot:

CNKR3_HUMAN :
  • Contains 1 CRIC domain.
  • Belongs to the CNKSR family.
Domain:
  • Contains 1 CRIC domain.
  • Contains 1 DUF1170 domain.
  • Contains 1 PDZ (DHR) domain.
  • Contains 1 SAM (sterile alpha motif) domain.
Family:
  • Belongs to the CNKSR family.
genes like me logo Genes that share domains with CNKSR3: view

Function for CNKSR3 Gene

Molecular function for CNKSR3 Gene

UniProtKB/Swiss-Prot Function:
Probably involved in transepithelial sodium transport. Regulates aldosterone-induced and ENaC-mediated sodium transport possibly through regulation of the ERK pathway (By similarity).
UniProtKB/Swiss-Prot Induction:
Up-regulated by aldosterone (at protein level).

Gene Ontology (GO) - Molecular Function for CNKSR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with CNKSR3: view
genes like me logo Genes that share phenotypes with CNKSR3: view

Animal Model Products

miRNA for CNKSR3 Gene

miRTarBase miRNAs that target CNKSR3

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CNKSR3 Gene

Localization for CNKSR3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CNKSR3 Gene COMPARTMENTS Subcellular localization image for CNKSR3 gene
Compartment Confidence
nucleus 4
cytosol 3

Gene Ontology (GO) - Cellular Components for CNKSR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with CNKSR3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CNKSR3 Gene

Pathways & Interactions for CNKSR3 Gene

SuperPathways for CNKSR3 Gene

No Data Available

Interacting Proteins for CNKSR3 Gene

Gene Ontology (GO) - Biological Process for CNKSR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009966 regulation of signal transduction IEA --
GO:0010765 positive regulation of sodium ion transport IEA,ISS --
GO:0033137 negative regulation of peptidyl-serine phosphorylation IEA,ISS --
GO:0070373 negative regulation of ERK1 and ERK2 cascade IEA,ISS --
GO:2000651 positive regulation of sodium ion transmembrane transporter activity IEA --
genes like me logo Genes that share ontologies with CNKSR3: view

No data available for Pathways by source and SIGNOR curated interactions for CNKSR3 Gene

Transcripts for CNKSR3 Gene

Unigene Clusters for CNKSR3 Gene

CNKSR family member 3:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CNKSR3 Gene

No ASD Table

Relevant External Links for CNKSR3 Gene

GeneLoc Exon Structure for
CNKSR3
ECgene alternative splicing isoforms for
CNKSR3

Expression for CNKSR3 Gene

mRNA expression in normal human tissues for CNKSR3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CNKSR3 Gene

This gene is overexpressed in Heart (63.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CNKSR3 Gene



Protein tissue co-expression partners for CNKSR3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CNKSR3 Gene:

CNKSR3

SOURCE GeneReport for Unigene cluster for CNKSR3 Gene:

Hs.16064
genes like me logo Genes that share expression patterns with CNKSR3: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CNKSR3 Gene

Orthologs for CNKSR3 Gene

This gene was present in the common ancestor of animals.

Orthologs for CNKSR3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CNKSR3 34 35
  • 99.38 (n)
-- 35
  • 2 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia -- 35
  • 94 (a)
ManyToMany
CNKSR3 34
  • 88.83 (n)
-- 35
  • 2 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 92 (a)
ManyToMany
-- 35
  • 2 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia IPCEF1 34
  • 88.68 (n)
-- 35
  • 49 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 88 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Cnksr3 34
  • 86.01 (n)
mouse
(Mus musculus)
Mammalia Cnksr3 34 16 35
  • 85.65 (n)
Ipcef1 35
  • 1 (a)
ManyToMany
chicken
(Gallus gallus)
Aves CNKSR3 34
  • 76.94 (n)
-- 35
  • 73 (a)
ManyToMany
-- 35
  • 2 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 39 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia cnksr3 34
  • 67.09 (n)
zebrafish
(Danio rerio)
Actinopterygii zgc:172112 34 35
  • 65.32 (n)
zgc:154018 35
  • 1 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta cnk 35
  • 10 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea cnk-1 35
  • 13 (a)
OneToMany
Species where no ortholog for CNKSR3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CNKSR3 Gene

ENSEMBL:
Gene Tree for CNKSR3 (if available)
TreeFam:
Gene Tree for CNKSR3 (if available)

Paralogs for CNKSR3 Gene

Paralogs for CNKSR3 Gene

(2) SIMAP similar genes for CNKSR3 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with CNKSR3: view

Variants for CNKSR3 Gene

Sequence variations from dbSNP and Humsavar for CNKSR3 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs10457092 -- 154,443,763(+) CTGAG(A/G)TAGGA intron-variant
rs10457093 -- 154,458,279(+) AGGGA(A/T)TGTGA intron-variant
rs10457904 -- 154,501,471(+) TCACC(C/T)ATCAC intron-variant
rs10536163 -- 154,456,708(+) GTCTC(-/A)AAAAA intron-variant
rs1054549 -- 154,414,346(-) GCCAT(C/G/T)CTGGA reference, synonymous-codon, missense

Structural Variations from Database of Genomic Variants (DGV) for CNKSR3 Gene

Variant ID Type Subtype PubMed ID
dgv1070n67 CNV loss 20364138
dgv3418n106 CNV deletion 24896259
esv2438778 CNV deletion 19546169
esv2670107 CNV deletion 23128226
esv2678574 CNV deletion 23128226
esv2732942 CNV deletion 23290073
esv2732943 CNV deletion 23290073
esv2759480 CNV loss 17122850
esv3361323 CNV insertion 20981092
esv3446 CNV loss 18987735
esv3540691 CNV deletion 23714750
esv3611320 CNV loss 21293372
esv3890967 CNV loss 25118596
nsv523663 CNV gain 19592680
nsv7981 CNV loss 18304495
nsv823879 CNV loss 20364138

Variation tolerance for CNKSR3 Gene

Residual Variation Intolerance Score: 15.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.52; 29.45% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CNKSR3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CNKSR3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CNKSR3 Gene

Disorders for CNKSR3 Gene

Relevant External Links for CNKSR3

Genetic Association Database (GAD)
CNKSR3
Human Genome Epidemiology (HuGE) Navigator
CNKSR3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CNKSR3

No disorders were found for CNKSR3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CNKSR3 Gene

Publications for CNKSR3 Gene

  1. Meta-analysis of Parkinson's disease: identification of a novel locus, RIT2. (PMID: 22451204) Pankratz N. … Foroud T. (Ann. Neurol. 2012) 3 46 64
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  3. Cnksr3 is a direct mineralocorticoid receptor target gene and plays a key role in the regulation of the epithelial sodium channel. (PMID: 19567370) Ziera T. … Borden S.A. (FASEB J. 2009) 3 4 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64

Products for CNKSR3 Gene

Sources for CNKSR3 Gene

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