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Aliases for CNKSR3 Gene

Aliases for CNKSR3 Gene

  • CNKSR Family Member 3 2 3 4
  • Membrane Associated Guanylate Kinase Interacting Protein-Like 1 2 3
  • Connector Enhancer Of KSR 3 3 4
  • CNK Homolog Protein 3 3 4
  • Maguin-Like Protein 3 4
  • MAGI1 3 4
  • CNK3 3 4
  • Membrane Associated Guanylate Kinase, WW And PDZ Domain Containing 1 3
  • Membrane-Associated Guanylate Kinase-Interacting Protein-Like 1 3
  • Connector Enhancer Of Kinase Suppressor Of Ras 3 3

External Ids for CNKSR3 Gene

Previous Symbols for CNKSR3 Gene

  • MAGI1

Summaries for CNKSR3 Gene

GeneCards Summary for CNKSR3 Gene

CNKSR3 (CNKSR Family Member 3) is a Protein Coding gene. Among its related pathways are Ras signaling pathway and G-protein signaling_H-RAS regulation pathway. An important paralog of this gene is CNKSR1.

UniProtKB/Swiss-Prot for CNKSR3 Gene

  • Probably involved in transepithelial sodium transport. Regulates aldosterone-induced and ENaC-mediated sodium transport possibly through regulation of the ERK pathway (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CNKSR3 Gene

Genomics for CNKSR3 Gene

Genomic Location for CNKSR3 Gene

154,159,828 bp from pter
154,510,659 bp from pter
350,832 bases
Minus strand

Genomic View for CNKSR3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CNKSR3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CNKSR3 Gene

Regulatory Elements for CNKSR3 Gene

Proteins for CNKSR3 Gene

  • Protein details for CNKSR3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Connector enhancer of kinase suppressor of ras 3
    Protein Accession:
    Secondary Accessions:
    • Q5SGD5
    • Q96N65

    Protein attributes for CNKSR3 Gene

    555 amino acids
    Molecular mass:
    61904 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CNKSR3 Gene

Proteomics data for CNKSR3 Gene at MOPED

Post-translational modifications for CNKSR3 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys305

Other Protein References for CNKSR3 Gene

No data available for DME Specific Peptides for CNKSR3 Gene

Domains for CNKSR3 Gene

Gene Families for CNKSR3 Gene

  • SAMD :Sterile alpha motif (SAM) domain containing

Protein Domains for CNKSR3 Gene


  • Contains 1 CRIC domain.:
    • Q6P9H4
  • Contains 1 DUF1170 domain.:
    • Q6P9H4
  • Contains 1 PDZ (DHR) domain.:
    • Q6P9H4
  • Contains 1 SAM (sterile alpha motif) domain.:
    • Q6P9H4
  • Belongs to the CNKSR family.:
    • Q6P9H4
genes like me logo Genes that share domains with CNKSR3: view

Function for CNKSR3 Gene

Molecular function for CNKSR3 Gene

UniProtKB/Swiss-Prot Function: Probably involved in transepithelial sodium transport. Regulates aldosterone-induced and ENaC-mediated sodium transport possibly through regulation of the ERK pathway (By similarity).
UniProtKB/Swiss-Prot Induction: Up-regulated by aldosterone (at protein level).

Gene Ontology (GO) - Molecular Function for CNKSR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004601 peroxidase activity --
GO:0005344 oxygen transporter activity --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with CNKSR3: view

Phenotypes for CNKSR3 Gene

genes like me logo Genes that share phenotypes with CNKSR3: view

miRNA for CNKSR3 Gene

miRTarBase miRNAs that target CNKSR3

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for CNKSR3 Gene

Localization for CNKSR3 Gene

Subcellular locations from

Jensen Localization Image for CNKSR3 Gene COMPARTMENTS Subcellular localization image for CNKSR3 gene
Compartment Confidence
cytosol 3
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CNKSR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with CNKSR3: view

Pathways for CNKSR3 Gene

genes like me logo Genes that share pathways with CNKSR3: view

Interacting Proteins for CNKSR3 Gene

Selected Interacting proteins: Q6P9H4-CNKR3_HUMAN for CNKSR3 Gene via UniProtKB I2D

Gene Ontology (GO) - Biological Process for CNKSR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006979 response to oxidative stress --
GO:0009966 regulation of signal transduction --
GO:0010765 positive regulation of sodium ion transport ISS --
GO:0015671 oxygen transport --
GO:0033137 negative regulation of peptidyl-serine phosphorylation ISS --
genes like me logo Genes that share ontologies with CNKSR3: view

Transcripts for CNKSR3 Gene

Unigene Clusters for CNKSR3 Gene

CNKSR family member 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CNKSR3 Gene

No ASD Table

Relevant External Links for CNKSR3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CNKSR3 Gene

mRNA expression in normal human tissues for CNKSR3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for CNKSR3 Gene

SOURCE GeneReport for Unigene cluster for CNKSR3 Gene Hs.16064

genes like me logo Genes that share expressions with CNKSR3: view

Orthologs for CNKSR3 Gene

This gene was present in the common ancestor of animals.

Orthologs for CNKSR3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia -- 37
  • 2 (a)
  • 99.38 (n)
  • 99.44 (a)
  • 99 (a)
(Bos Taurus)
Mammalia -- 37
  • 2 (a)
-- 37
  • 94 (a)
  • 88.83 (n)
  • 94.23 (a)
(Canis familiaris)
Mammalia -- 37
  • 49 (a)
  • 88.68 (n)
  • 93.69 (a)
(Mus musculus)
Mammalia Cnksr3 36
  • 85.65 (n)
  • 92.25 (a)
Cnksr3 16
Cnksr3 37
  • 92 (a)
Ipcef1 37
  • 1 (a)
(Monodelphis domestica)
Mammalia -- 37
  • 2 (a)
-- 37
  • 92 (a)
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 88 (a)
(Rattus norvegicus)
Mammalia Cnksr3 36
  • 86.01 (n)
  • 92.43 (a)
(Gallus gallus)
Aves -- 37
  • 2 (a)
-- 37
  • 73 (a)
  • 76.94 (n)
  • 86.31 (a)
(Anolis carolinensis)
Reptilia -- 37
  • 39 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cnksr3 36
  • 67.09 (n)
  • 69.76 (a)
(Danio rerio)
Actinopterygii zgc:154018 37
  • 1 (a)
zgc:172112 36
  • 65.32 (n)
  • 64.52 (a)
zgc:172112 37
  • 63 (a)
fruit fly
(Drosophila melanogaster)
Insecta cnk 37
  • 10 (a)
(Caenorhabditis elegans)
Secernentea cnk-1 37
  • 13 (a)
Species with no ortholog for CNKSR3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CNKSR3 Gene

Gene Tree for CNKSR3 (if available)
Gene Tree for CNKSR3 (if available)

Paralogs for CNKSR3 Gene

Paralogs for CNKSR3 Gene

Selected SIMAP similar genes for CNKSR3 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with CNKSR3: view

Variants for CNKSR3 Gene

Sequence variations from dbSNP and Humsavar for CNKSR3 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs883652 -- 154,460,738(-) GGTGT(C/T)TGGTT intron-variant
rs883987 -- 154,460,021(+) CTGAC(C/G)ACTGT intron-variant
rs946234 -- 154,461,725(-) AAATA(A/G)TAGCG intron-variant
rs946235 -- 154,458,893(-) TTCCA(A/G)TCCAG intron-variant
rs946236 -- 154,482,749(+) CTAGA(A/G)TTCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CNKSR3 Gene

Variant ID Type Subtype PubMed ID
nsv886787 CNV Gain 21882294
nsv7981 CNV Loss 18304495
dgv2020e1 CNV Complex 17122850
nsv523663 CNV Gain 19592680
esv2438778 CNV Deletion 19546169
esv3446 CNV Deletion 18987735
esv2678574 CNV Deletion 23128226
esv2732942 CNV Deletion 23290073
esv2732943 CNV Deletion 23290073
esv2670107 CNV Deletion 23128226
nsv823879 CNV Loss 20364138
dgv1070n67 CNV Loss 20364138

Relevant External Links for CNKSR3 Gene

HapMap Linkage Disequilibrium report

Disorders for CNKSR3 Gene

Relevant External Links for CNKSR3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with CNKSR3: view

No data available for UniProtKB/Swiss-Prot for CNKSR3 Gene

Publications for CNKSR3 Gene

  1. Meta-analysis of Parkinson's disease: identification of a novel locus, RIT2. (PMID: 22451204) Pankratz N. … Foroud T. (Ann. Neurol. 2012) 3 49
  2. Cnksr3 is a direct mineralocorticoid receptor target gene and plays a key role in the regulation of the epithelial sodium channel. (PMID: 19567370) Ziera T. … Borden S.A. (FASEB J. 2009) 3 4
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 49
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. Delta proteins and MAGI proteins: an interaction of Notch ligands with intracellular scaffolding molecules and its significance for zebrafish development. (PMID: 15509766) Wright G.J. … Lewis J. (Development 2004) 3

Products for CNKSR3 Gene

  • antibodies-online proteins for CNKSR3
  • antibodies-online antibodies for CNKSR3
  • antibodies-online kits for CNKSR3

Sources for CNKSR3 Gene

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