CNKSR3 Gene
protein-coding GIFtS: 46
GCID: GC06M154819
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CNKSR family member 3(Previous name: membrane associated guanylate kinase interacting protein-like...)
(Previous symbol: MAGI1)
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Aliases
for CNKSR3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| CNKSR Family Member 31 2 3 | | CNK Homolog Protein 32 3 | | MAGI11 2 3 | | FLJ313491 | | Membrane Associated Guanylate Kinase Interacting Protein-Like 11 2 | | Connector Enhancer Of Kinase Suppressor Of Ras 32 | | Connector Enhancer Of KSR 32 3 | | Membrane Associated Guanylate Kinase, WW And PDZ Domain Containing 12 | | Maguin-Like Protein2 3 | | Membrane-Associated Guanylate Kinase-Interacting Protein-Like 12 | | CNK32 3 | | |
Export aliases for CNKSR3 gene to outside databasesPrevious GC identifer: GC06M152289 |
Summaries
for CNKSR3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: CNKR3_HUMAN, Q6P9H4Function: Probably involved in transepithelial sodium transport. Regulates aldosterone-induced and ENaC-mediated sodiumtransport possibly through regulation of the ERK pathway (By similarity)
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Genomic Views
for CNKSR3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000006.11 NC_018917.1 NT_025741.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CNKSR3 gene promoter:
c-Fos E2F-3a E2F-4 E2F-5 AP-1 E2F-2 AREB6 E2F-1 E2F c-Jun
Other transcription factors
Search SABiosciences Chromatin IP Primers for CNKSR3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CNKSR3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6q25.2 Ensembl cytogenetic band: 6q25.2 HGNC cytogenetic band: 6q25.2CNKSR3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06M154819: view genomic region
(about GC identifiers)
Start:
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154,726,433 bp from pter |
End:
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154,831,793 bp from pter |
Size:
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105,361 bases |
Orientation:
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minus strand |
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Proteins
for CNKSR3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CNKR3_HUMAN, Q6P9H4 (See
protein sequence)Recommended Name: Connector enhancer of kinase suppressor of ras 3 Size: 555 amino acids; 61904 Da
Caution: The gene name MAGI1, shown in this entry as a synonym, is an obsolete human gene nomenclaturecommittee-approved name. It should be noted that MAGI1 currently is the official name for the unrelatedmembrane-associated guanylate kinase, WW and PDZ domain-containing protein 1
Secondary accessions: Q5SGD5 Q96N65Explore the universe of human proteins at neXtProt for CNKSR3: NX_Q6P9H4
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6P9H4
CNKSR3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_775786.2
ENSEMBL proteins: ENSP00000356182 ENSP00000414185 ENSP00000418975 ENSP00000393225 ENSP00000406740
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
CNKSR3 for ontologies About GeneDecksing
CNKSR3 Antibody Products:
Assay Products for CNKSR3: |
Protein
Domains /
Families
for CNKSR3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CNKSR3 for domains About GeneDecksing
5/7 InterPro domains/families (see all 7):Graphical View of Domain Structure for InterPro Entry Q6P9H4ProtoNet protein and cluster: Q6P9H4 1 Blocks protein family: IPB001660 Sterile alpha motif SAM
UniProtKB/Swiss-Prot: CNKR3_HUMAN, Q6P9H4Similarity: Belongs to the CNKSR familySimilarity: Contains 1 CRIC domainSimilarity: Contains 1 DUF1170 domainSimilarity: Contains 1 PDZ (DHR) domainSimilarity: Contains 1 SAM (sterile alpha motif) domain |
Function
for CNKSR3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: CNKR3_HUMAN, Q6P9H4Function: Probably involved in transepithelial sodium transport. Regulates aldosterone-induced and ENaC-mediated sodiumtransport possibly through regulation of the ERK pathway (By similarity)Induction: Up-regulated by aldosterone (at protein level)
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CNKSR3
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CNKSR3 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016301 | kinase activity |
-- | -- |
CNKSR3 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for CNKSR3:
|
Pathways & Interactions
for CNKSR3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CNKSR3
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
3 Interacting proteins for CNKSR3 (Q6P9H43 ENSP000003561824) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0009966 | regulation of signal transduction |
-- | -- | | GO:0010765 | positive regulation of sodium ion transport |
ISS | -- | | GO:0033137 | negative regulation of peptidyl-serine phosphorylation |
ISS | -- | | GO:0070373 | negative regulation of ERK1 and ERK2 cascade |
ISS | -- |
CNKSR3 for ontologies About GeneDecksing
|
Drugs & Compounds
for CNKSR3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CNKSR3
Search CenterWatch for drugs/clinical trials and news about CNKSR3 / CNKR3
|
Transcripts
for CNKSR3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CNKSR3 gene: NM_173515.2 Unigene Cluster for CNKSR3: CNKSR family member 3 Hs.16064 [show with all ESTs]Unigene Representative Sequence: AY3288915 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000367213(uc003qpy.3) ENST00000433165 ENST00000479339 ENST00000424998
ENST00000454664
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CNKSR3 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CNKSR3
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: CNKSR3 (NM_173515) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CNKSR3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CNKSR3 |
Additional cDNA sequence: AK055911.1 AK309680.1 AY328891.1 AY328892.1 AY328893.1 AY328894.1 BC060761.1 JF308526.1 5 DOTS entries: DT.412200 DT.121354645 DT.75109462 DT.95114263 DT.95161528 24/70 AceView cDNA sequences (see all 70): BX283773 AI192533 AI378638 CA440768 CA413723 AW135351 AW955970 BU728958 AI689890 BM985338 AI190915 BF979450 H30177 BG563701 AA430235 AK055911 BG771485 AA330269 AW172705 BU735335 BM696281 BQ014502 AA911697 AI659925
GeneLoc Exon Structure
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Expression
for CNKSR3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CNKSR3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTCACTAATT
About this image
See CNKSR3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CNKSR3
SOURCE GeneReport for Unigene cluster: Hs.16064
SABiosciences Custom PCR Arrays for CNKSR3
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CNKSR3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CNKSR3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CNKSR3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CNKSR3 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CNKSR3 |
Orthologs
for CNKSR3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for CNKSR3 gene from 5/16 species (see all 16) About this table
ENSEMBL Gene Tree for CNKSR3 (if available)
TreeFam Gene Tree for CNKSR3 (if available) |
Paralogs
for CNKSR3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CNKSR3 gene
- IPCEF12 CNKSR12 CNKSR22
2 SIMAP similar genes for CNKSR3 using alignment to 5 protein entries: CNKR3_HUMAN (see all proteins):CNKSR2 CNKSR1
CNKSR3 for paralogs About GeneDecksing
|
Genomic Variants
for CNKSR3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 6 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CNKSR3 (154726433 - 154831793 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for CNKSR3
2 CNVs: 2658 99765
1 Indel: 41683 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CNKSR3 |
|
Disorders
/ Diseases
for CNKSR3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CNKSR3 for disorders About GeneDecksing
1  disease for CNKSR3: About MalaCardsaldosteronism
Human Genome Epidemiology (HuGE) Navigator: CNKSR3 (1 document)
Export disorders for CNKSR3 gene to outside databases
|
Publications
for CNKSR3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CNKSR3 gene, integrated from 9 sources (see all 14):
(articles sorted by number of sources associating them with CNKSR3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Cnksr3 is a direct mineralocorticoid receptor target gene and plays a key role in the regulation of the epithelial sodium channel. (PubMed id 19567370)1, 2 Ziera T....Borden S.A. (2009)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Differential gene expression profile in PBMCs from sub jects with AERD and ATA: a gene marker for AERD. (PubMed id 22457146)1 Shin S....Park C.S. (2012)
- Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations. (PubMed id 22797727)1 Okada Y....Tanaka T. (2012)
- Meta-analysis of Parkinson's disease: identification o f a novel locus, RIT2. (PubMed id 22451204)1 Pankratz N....Foroud T. (2012)
- Scaffold protein connector enhancer of kinase suppress or of Ras isoform 3 (CNK3) coordinates assembly of a multiprotein epithelial sod ium channel (ENaC)-regulatory complex. (PubMed id 22851176)1 Soundararajan R....Pearce D. (2012)
- CNK3 and IPCEF1 produce a single protein that is required for HGF dependent Arf6 activation and migration. (PubMed id 22085542)1 Attar M.A.... Santy L.C. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
|
External Searches for CNKSR3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing CNKSR3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CNKSR3 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CNKSR3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CNKSR3 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for CNKSR3 gene:
Search GeneIP for patents involving CNKSR3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CNKSR3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for CNKSR3 | | OriGene shRNA RFP for CNKSR3 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CNKSR3 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CNKSR3 | | | OriGene Protein Over-expression Lysate for CNKSR3 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CNKSR3 | | OriGene 3'-UTR Clone for CNKSR3 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CNKSR3 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CNKSR3 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CNKSR3 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CNKSR3 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CNKSR3 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CNKSR3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CNKSR3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CNKSR3 |
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 | | | CNKSR3 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CNKSR3 |
|  |  |  | | | | Search ThermoFisher Antibodies for CNKSR3 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CNKSR3 |
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