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Aliases for CNKSR3 Gene

Aliases for CNKSR3 Gene

  • CNKSR Family Member 3 2 3 4 5
  • Membrane Associated Guanylate Kinase Interacting Protein-Like 1 2 3
  • Connector Enhancer Of KSR 3 3 4
  • CNK Homolog Protein 3 3 4
  • Maguin-Like Protein 3 4
  • MAGI1 3 4
  • CNK3 3 4
  • Membrane Associated Guanylate Kinase, WW And PDZ Domain Containing 1 3
  • Membrane-Associated Guanylate Kinase-Interacting Protein-Like 1 3

External Ids for CNKSR3 Gene

Previous HGNC Symbols for CNKSR3 Gene

  • MAGI1

Previous GeneCards Identifiers for CNKSR3 Gene

  • GC06M154819
  • GC06M152289
  • GC06M154708

Summaries for CNKSR3 Gene

GeneCards Summary for CNKSR3 Gene

CNKSR3 (CNKSR Family Member 3) is a Protein Coding gene. GO annotations related to this gene include peroxidase activity and oxygen transporter activity. An important paralog of this gene is CNKSR1.

UniProtKB/Swiss-Prot for CNKSR3 Gene

  • Probably involved in transepithelial sodium transport. Regulates aldosterone-induced and ENaC-mediated sodium transport possibly through regulation of the ERK pathway (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CNKSR3 Gene

Genomics for CNKSR3 Gene

Regulatory Elements for CNKSR3 Gene

Enhancers for CNKSR3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CNKSR3 on UCSC Golden Path with GeneCards custom track

Promoters for CNKSR3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CNKSR3 on UCSC Golden Path with GeneCards custom track

Genomic Location for CNKSR3 Gene

154,159,828 bp from pter
154,510,659 bp from pter
350,832 bases
Minus strand

Genomic View for CNKSR3 Gene

Genes around CNKSR3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CNKSR3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CNKSR3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CNKSR3 Gene

Proteins for CNKSR3 Gene

  • Protein details for CNKSR3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Connector enhancer of kinase suppressor of ras 3
    Protein Accession:
    Secondary Accessions:
    • Q5SGD5
    • Q96N65

    Protein attributes for CNKSR3 Gene

    555 amino acids
    Molecular mass:
    61904 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CNKSR3 Gene

Proteomics data for CNKSR3 Gene at MOPED

Post-translational modifications for CNKSR3 Gene

  • Ubiquitination at Lys 305
  • Modification sites at PhosphoSitePlus

Other Protein References for CNKSR3 Gene

No data available for DME Specific Peptides for CNKSR3 Gene

Domains & Families for CNKSR3 Gene

Protein Domains for CNKSR3 Gene

Suggested Antigen Peptide Sequences for CNKSR3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 CRIC domain.
  • Belongs to the CNKSR family.
  • Contains 1 CRIC domain.
  • Contains 1 DUF1170 domain.
  • Contains 1 PDZ (DHR) domain.
  • Contains 1 SAM (sterile alpha motif) domain.
  • Belongs to the CNKSR family.
genes like me logo Genes that share domains with CNKSR3: view

Function for CNKSR3 Gene

Molecular function for CNKSR3 Gene

UniProtKB/Swiss-Prot Function:
Probably involved in transepithelial sodium transport. Regulates aldosterone-induced and ENaC-mediated sodium transport possibly through regulation of the ERK pathway (By similarity).
UniProtKB/Swiss-Prot Induction:
Up-regulated by aldosterone (at protein level).
genes like me logo Genes that share phenotypes with CNKSR3: view

Animal Model Products

miRNA for CNKSR3 Gene

miRTarBase miRNAs that target CNKSR3

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CNKSR3 Gene

Localization for CNKSR3 Gene

Subcellular locations from

Jensen Localization Image for CNKSR3 Gene COMPARTMENTS Subcellular localization image for CNKSR3 gene
Compartment Confidence
nucleus 4
cytosol 3

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CNKSR3 Gene

Pathways & Interactions for CNKSR3 Gene

SuperPathways for CNKSR3 Gene

No Data Available

Interacting Proteins for CNKSR3 Gene

Selected Interacting proteins: Q6P9H4-CNKR3_HUMAN for CNKSR3 Gene via UniProtKB I2D

Gene Ontology (GO) - Biological Process for CNKSR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0033137 negative regulation of peptidyl-serine phosphorylation ISS --
GO:0070373 negative regulation of ERK1 and ERK2 cascade ISS --
genes like me logo Genes that share ontologies with CNKSR3: view

No data available for Pathways by source and SIGNOR curated interactions for CNKSR3 Gene

Drugs & Compounds for CNKSR3 Gene

No Compound Related Data Available

Transcripts for CNKSR3 Gene

Unigene Clusters for CNKSR3 Gene

CNKSR family member 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CNKSR3 Gene

No ASD Table

Relevant External Links for CNKSR3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CNKSR3 Gene

mRNA expression in normal human tissues for CNKSR3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CNKSR3 Gene

This gene is overexpressed in Heart (63.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for CNKSR3 Gene

SOURCE GeneReport for Unigene cluster for CNKSR3 Gene Hs.16064

genes like me logo Genes that share expression patterns with CNKSR3: view

Protein tissue co-expression partners for CNKSR3 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CNKSR3 Gene

Orthologs for CNKSR3 Gene

This gene was present in the common ancestor of animals.

Orthologs for CNKSR3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CNKSR3 35
  • 88.83 (n)
  • 94.23 (a)
-- 36
  • 2 (a)
-- 36
  • 94 (a)
(Canis familiaris)
Mammalia IPCEF1 35
  • 88.68 (n)
  • 93.69 (a)
-- 36
  • 49 (a)
(Mus musculus)
Mammalia Cnksr3 35
  • 85.65 (n)
  • 92.25 (a)
Cnksr3 16
Cnksr3 36
  • 92 (a)
Ipcef1 36
  • 1 (a)
(Pan troglodytes)
Mammalia CNKSR3 35
  • 99.38 (n)
  • 99.44 (a)
-- 36
  • 2 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Cnksr3 35
  • 86.01 (n)
  • 92.43 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 2 (a)
-- 36
  • 92 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 88 (a)
(Gallus gallus)
Aves CNKSR3 35
  • 76.94 (n)
  • 86.31 (a)
-- 36
  • 2 (a)
-- 36
  • 73 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 39 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cnksr3 35
  • 67.09 (n)
  • 69.76 (a)
(Danio rerio)
Actinopterygii zgc:172112 35
  • 65.32 (n)
  • 64.52 (a)
zgc:154018 36
  • 1 (a)
zgc:172112 36
  • 63 (a)
fruit fly
(Drosophila melanogaster)
Insecta cnk 36
  • 10 (a)
(Caenorhabditis elegans)
Secernentea cnk-1 36
  • 13 (a)
Species with no ortholog for CNKSR3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CNKSR3 Gene

Gene Tree for CNKSR3 (if available)
Gene Tree for CNKSR3 (if available)

Paralogs for CNKSR3 Gene

Paralogs for CNKSR3 Gene

(2) SIMAP similar genes for CNKSR3 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with CNKSR3: view

Variants for CNKSR3 Gene

Sequence variations from dbSNP and Humsavar for CNKSR3 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1054549 -- 154,414,346(-) GCCAT(C/G/T)CTGGA reference, synonymous-codon, missense
rs1054550 -- 154,411,020(-) ATTCA(A/C)CATTG reference, missense
rs1105909 -- 154,462,680(-) GGGAC(C/T)TCACA intron-variant
rs1112134 -- 154,432,165(-) ccaaa(C/T)gctgc intron-variant
rs1143440 -- 154,419,215(-) ttttt(A/T)ttttt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CNKSR3 Gene

Variant ID Type Subtype PubMed ID
nsv886787 CNV Gain 21882294
nsv7981 CNV Loss 18304495
dgv2020e1 CNV Complex 17122850
nsv523663 CNV Gain 19592680
esv2438778 CNV Deletion 19546169
esv3446 CNV Deletion 18987735
esv2678574 CNV Deletion 23128226
esv2732942 CNV Deletion 23290073
esv2732943 CNV Deletion 23290073
esv2670107 CNV Deletion 23128226
nsv823879 CNV Loss 20364138
dgv1070n67 CNV Loss 20364138

Variation tolerance for CNKSR3 Gene

Residual Variation Intolerance Score: 15.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.52; 29.45% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for CNKSR3 Gene

Disorders for CNKSR3 Gene

Relevant External Links for CNKSR3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CNKSR3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CNKSR3 Gene

Publications for CNKSR3 Gene

  1. Meta-analysis of Parkinson's disease: identification of a novel locus, RIT2. (PMID: 22451204) Pankratz N. … Foroud T. (Ann. Neurol. 2012) 3 48 67
  2. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. Single nucleotide polymorphism array analysis of uveal melanomas reveals that amplification of CNKSR3 is correlated with improved patient survival. (PMID: 23357503) Lake S.L. … Coupland S.E. (Am. J. Pathol. 2013) 3
  5. Differential gene expression profile in PBMCs from subjects with AERD and ATA: a gene marker for AERD. (PMID: 22457146) Shin S. … Park C.S. (Mol. Genet. Genomics 2012) 3

Products for CNKSR3 Gene

Sources for CNKSR3 Gene