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CNKSR3 Gene

protein-coding   GIFtS: 50
GCID: GC06M154708

CNKSR Family Member 3

(Previous name: membrane associated guanylate kinase interacting protein-like...)
(Previous symbol: MAGI1)
Alzheimer's & Parkinson's Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
CNKSR Family Member 31 2 3     CNK32 3
MAGI11 2 3     CNK Homolog Protein 32 3
Membrane Associated Guanylate Kinase Interacting Protein-Like 11 2     Connector Enhancer Of Kinase Suppressor Of Ras 32
Connector Enhancer Of KSR 32 3     Membrane Associated Guanylate Kinase, WW And PDZ Domain Containing 12
Maguin-Like Protein2 3     Membrane-Associated Guanylate Kinase-Interacting Protein-Like 12

External Ids:    HGNC: 230341   Entrez Gene: 1540432   Ensembl: ENSG000001537217   UniProtKB: Q6P9H43   

Export aliases for CNKSR3 gene to outside databases

Previous GC identifers: GC06M154819 GC06M152289


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CNKSR3 Gene:
CNKSR3 (CNKSR family member 3) is a protein-coding gene. Diseases associated with CNKSR3 include parkinson's disease, and melanoma. An important paralog of this gene is IPCEF1.

UniProtKB/Swiss-Prot: CNKR3_HUMAN, Q6P9H4
Function: Probably involved in transepithelial sodium transport. Regulates aldosterone-induced and ENaC-mediated
sodium transport possibly through regulation of the ERK pathway (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000006.12  NC_018917.2  NT_025741.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the CNKSR3 gene promoter:
         c-Fos   E2F-3a   E2F-4   E2F-5   AP-1   E2F-2   AREB6   E2F-1   E2F   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCNKSR3 promoter sequence
   Search Chromatin IP Primers for CNKSR3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CNKSR3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q25.2   Ensembl cytogenetic band:  6q25.2   HGNC cytogenetic band: 6q25.2

CNKSR3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CNKSR3 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M154708:  view genomic region     (about GC identifiers)

Start:
154,708,638 bp from pter      End:
154,831,793 bp from pter
Size:
123,156 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: CNKR3_HUMAN, Q6P9H4 (See protein sequence)
Recommended Name: Connector enhancer of kinase suppressor of ras 3  
Size: 555 amino acids; 61904 Da
Caution: The gene name MAGI1, shown in this entry as a synonym, is an obsolete human gene nomenclature
committee-approved name. It should be noted that MAGI1 currently is the official name for the unrelated
membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1
Secondary accessions: Q5SGD5 Q96N65

Explore the universe of human proteins at neXtProt for CNKSR3: NX_Q6P9H4

Explore proteomics data for CNKSR3 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys305
  • Modification sites at PhosphoSitePlus

  • See CNKSR3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_775786.2  
    ENSEMBL proteins: 
     ENSP00000475915   ENSP00000414185   ENSP00000418975   ENSP00000393225   ENSP00000406740  

    CNKSR3 Human Recombinant Protein Products:

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    Novus Biologicals CNKSR3 Proteins
    Novus Biologicals CNKSR3 Lysates
    Sino Biological Recombinant Protein for CNKSR3
    Sino Biological Cell Lysate for CNKSR3
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    Cloud-Clone Corp. Proteins for CNKSR3

    CNKSR3 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Abcam antibodies for CNKSR3
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    CNKSR3 Assay Products:

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    Cloud-Clone Corp. ELISAs for CNKSR3
    Cloud-Clone Corp. CLIAs for CNKSR3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SAMD: Sterile alpha motif (SAM) domain containing

    Selected InterPro protein domains (see all 7):
     IPR010599 CNKSR2
     IPR021129 SAM_type1
     IPR013761 SAM/pointed
     IPR001660 SAM
     IPR001478 PDZ

    Graphical View of Domain Structure for InterPro Entry Q6P9H4

    ProtoNet protein and cluster: Q6P9H4

    1 Blocks protein domain: IPB001660 Sterile alpha motif SAM

    UniProtKB/Swiss-Prot: CNKR3_HUMAN, Q6P9H4
    Similarity: Belongs to the CNKSR family
    Similarity: Contains 1 CRIC domain
    Similarity: Contains 1 DUF1170 domain
    Similarity: Contains 1 PDZ (DHR) domain
    Similarity: Contains 1 SAM (sterile alpha motif) domain


    CNKSR3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CNKR3_HUMAN, Q6P9H4
    Function: Probably involved in transepithelial sodium transport. Regulates aldosterone-induced and ENaC-mediated
    sodium transport possibly through regulation of the ERK pathway (By similarity)
    Induction: Up-regulated by aldosterone (at protein level)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    CNKSR3 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for CNKSR3:
     Decreased cilium length after   Increased S DNA content 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CNKSR3
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CNKSR3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CNKSR3

    miRNA
    Products:
        
    miRTarBase miRNAs that target CNKSR3:
    hsa-mir-124-3p (MIRT022563)

    Block miRNA regulation of human, mouse, rat CNKSR3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CNKSR3 (see all 21):
    hsa-miR-495 hsa-miR-300 hsa-miR-181c hsa-miR-429 hsa-miR-487a hsa-miR-485-3p hsa-miR-124 hsa-miR-7-1*
    SwitchGear 3'UTR luciferase reporter plasmidCNKSR3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CNKSR3
    Predesigned siRNA for gene silencing in human, mouse, rat CNKSR3

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for CNKSR3

    Clone
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    OriGene clones in human, mouse for CNKSR3 (see all 7)
    OriGene ORF clones in mouse, rat for CNKSR3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CNKSR3 (NM_173515)
    Sino Biological Human cDNA Clone for CNKSR3
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CNKSR3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CNKSR3

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for CNKSR3 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CNKSR3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus2
    mitochondrion1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0016020membrane IEA--

    CNKSR3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CNKSR3
    Interactions:

        Search GeneGlobe Interaction Network for CNKSR3

    2 Interacting proteins for CNKSR3 (Q6P9H43) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BAIAP2Q9UQB83I2D: score=1 
    DLL1O005483I2D: score=1 
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0009966regulation of signal transduction ----
    GO:0010765positive regulation of sodium ion transport ISS--
    GO:0033137negative regulation of peptidyl-serine phosphorylation ISS--
    GO:0070373negative regulation of ERK1 and ERK2 cascade ISS--

    CNKSR3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CNKSR3 (CNKR3)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CNKSR3 gene: 
    NM_173515.2  

    Unigene Cluster for CNKSR3:

    CNKSR family member 3
    Hs.16064  [show with all ESTs]
    Unigene Representative Sequence: AY328891
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000607772 ENST00000433165 ENST00000479339 ENST00000424998 ENST00000454664


    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CNKSR3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CNKSR3 (see all 21):
    hsa-miR-495 hsa-miR-300 hsa-miR-181c hsa-miR-429 hsa-miR-487a hsa-miR-485-3p hsa-miR-124 hsa-miR-7-1*
    SwitchGear 3'UTR luciferase reporter plasmidCNKSR3 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CNKSR3
    Predesigned siRNA for gene silencing in human, mouse, rat CNKSR3
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    OriGene clones in human, mouse for CNKSR3 (see all 7)
    OriGene ORF clones in mouse, rat for CNKSR3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CNKSR3 (NM_173515)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CNKSR3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CNKSR3
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CNKSR3
    OriGene qSTAR qPCR primer pairs in human, mouse for CNKSR3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CNKSR3
      QuantiTect SYBR Green Assays in human, mouse, rat CNKSR3
      QuantiFast Probe-based Assays in human, mouse, rat CNKSR3

    Additional mRNA sequence: 

    AK055911.1 AK309680.1 AY328891.1 AY328892.1 AY328893.1 AY328894.1 BC060761.1 JF308526.1 

    5 DOTS entries:

    DT.412200  DT.121354645  DT.75109462  DT.95114263  DT.95161528 

    Selected AceView cDNA sequences (see all 70):

    CA413723 AI192533 BM985338 AI689890 BX283773 AW135351 AW955970 AI378638 
    CA440768 BU728958 CA389377 CA309383 BM701183 AW962509 AA383620 AA330598 
    BG563701 H30177 AA430235 AI190915 BF979450 BQ772179 AI559494 T91236 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CNKSR3 expression in normal human tissues (normalized intensities)      CNKSR3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTCACTAATT
    CNKSR3 Expression
    About this image


    CNKSR3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Blood (Hematopoietic System)
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
    CNKSR3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CNKSR3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.16064
        Custom PCR Arrays for CNKSR3
    Primer
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    OriGene qPCR primer pairs and template standards for CNKSR3
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CNKSR3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CNKSR3 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cnksr31 , 5 Cnksr family member 31, 5 85.65(n)1
    92.25(a)1
      10 (1.85 cM)5
    2157481  NM_172546.21  NP_766134.11 
     71190635 
    chicken
    (Gallus gallus)
    Aves CNKSR31 CNKSR family member 3 76.94(n)
    86.31(a)
      421646  XM_419685.4  XP_419685.4 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    39(a)
    1 → many
    1(215103884-215233604)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia cnksr31 CNKSR family member 3 67.09(n)
    69.76(a)
      100216222  NM_001142190.1  NP_001135662.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1721121 zgc:172112 65.32(n)
    64.52(a)
      100003037  NM_001113647.1  NP_001107119.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta cnk6
    connector enhancer of ksr
    10(a)
    1 → many
    2R(13301476-13307104)
    worm
    (Caenorhabditis elegans)
    Secernentea cnk-16
    Protein CNK-1 (cnk-1) mRNA, complete cds
    13(a)
    1 → many
    III(10271257-10278579) WBGene00000564


    ENSEMBL Gene Tree for CNKSR3 (if available)
    TreeFam Gene Tree for CNKSR3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CNKSR3 gene
    IPCEF12  CNKSR12  CNKSR22  
    2 SIMAP similar genes for CNKSR3 using alignment to 5 protein entries:     CNKR3_HUMAN (see all proteins):
    CNKSR2    CNKSR1

    CNKSR3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CNKSR3 (see all 2447)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1832587841,2
    --154725942(+) GCCTGC/GGTGAC 1 -- int10--------
    rs2009385751,2
    C--154725984(+) CAAAC-/AAAA  
            
    AAAAC
    1 -- int10--------
    rs795084291,2
    C--154725987(+) ACAAAC/AAAAAC 1 -- int11Minor allele frequency- A:0.50WA 2
    rs1886760161,2
    --154726053(+) AACCAC/TACCAG 1 -- int10--------
    rs1176648821,2
    C,F--154726143(+) ATTCCG/AGTGGT 1 -- int11Minor allele frequency- A:0.01NA 120
    rs1509196671,2
    C--154726174(+) GTAGGA/GGATTT 1 -- int10--------
    rs1407970911,2
    C--154726202(+) ATACCC/TCAGAA 1 -- int10--------
    rs1501130701,2
    --154726393(+) GCTTCA/GTGTAT 1 -- int10--------
    rs624335931,2
    C,F--154726639(+) TTTGAA/CGAAGT 1 -- ut313Minor allele frequency- C:0.05WA NA 124
    rs77645271,2
    C,F,A,H--154726694(+) AAACTC/GATGTA 1 -- ut31 ese315Minor allele frequency- G:0.11NS EA NA WA 1222

    HapMap Linkage Disequilibrium report for CNKSR3 (154708638 - 154831793 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for CNKSR3 (see all 12):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2732942CNV Deletion23290073
    esv2670107CNV Deletion23128226
    esv2732943CNV Deletion23290073
    esv2438778CNV Deletion19546169
    esv2678574CNV Deletion23128226
    esv3446CNV Deletion18987735
    nsv7981CNV Loss18304495
    nsv823879CNV Loss20364138
    dgv1070n67CNV Loss20364138
    nsv886787CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CNKSR3
    DNA2.0 Custom Variant and Variant Library Synthesis for CNKSR3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    2 diseases for CNKSR3:    About MalaCards
    parkinson's disease    melanoma


    CNKSR3 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): CNKSR3
    Human Genome Epidemiology (HuGE) Navigator: CNKSR3 (1 document)

    Export disorders for CNKSR3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CNKSR3 gene, integrated from 10 sources (see all 17):
    (articles sorted by number of sources associating them with CNKSR3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Meta-analysis of Parkinson's disease: identification of a novel locus, RIT2. (PubMed id 22451204)1, 4 Pankratz N....Foroud T. (Ann. Neurol. 2012)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. Cnksr3 is a direct mineralocorticoid receptor target gene and plays a key role in the regulation of the epithelial sodium channel. (PubMed id 19567370)1, 2 Ziera T.... Borden S.A. (FASEB J. 2009)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    6. Single nucleotide polymorphism array analysis of uveal melanomas reveals that amplification of CNKSR3 is correlated with improved patient survival. (PubMed id 23357503)1 Lake S.L....Coupland S.E. (Am. J. Pathol. 2013)
    7. Differential gene expression profile in PBMCs from subjects with AERD and ATA: a gene marker for AERD. (PubMed id 22457146)1 Shin S....Park C.S. (Mol. Genet. Genomics 2012)
    8. Scaffold protein connector enhancer of kinase suppressor of Ras isoform 3 (CNK3) coordinates assembly of a multiprotein epithelial sodium channel (ENaC)-regulatory complex. (PubMed id 22851176)1 Soundararajan R....Pearce D. (J. Biol. Chem. 2012)
    9. Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations. (PubMed id 22797727)1 Okada Y....Tanaka T. (Nat. Genet. 2012)
    10. CNK3 and IPCEF1 produce a single protein that is required for HGF dependent Arf6 activation and migration. (PubMed id 22085542)1 Attar M.A.... Santy L.C. (Exp. Cell Res. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 154043 HGNC: 23034 AceView: MAGI1 Ensembl:ENSG00000153721 euGenes: HUgn154043
    ECgene: CNKSR3 H-InvDB: CNKSR3

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CNKSR3 Pharmacogenomics, SNPs, Pathways

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    Patent Information for CNKSR3 gene:
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