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CNKSR2 Gene

protein-coding   GIFtS: 57
GCID: GC0XP021392

Connector Enhancer Of Kinase Suppressor Of Ras 2

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Connector Enhancer Of Kinase Suppressor Of Ras 21 2     KIAA09023 5
CNK22 3 5     MAGUIN2
Connector Enhancer Of KSR 22 3     Connector Enhancer Of KSR22
KSR22 3     Membrane-Associated Guanylate Kinase-Interacting Protein2
CNK Homolog Protein 22 3     

External Ids:    HGNC: 197011   Entrez Gene: 228662   Ensembl: ENSG000001499707   OMIM: 3007245   UniProtKB: Q8WXI23   

Export aliases for CNKSR2 gene to outside databases

Previous GC identifers: GC0XP020754 GC0XP021152 GC0XP021302 GC0XP019116


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CNKSR2 Gene:
This gene encodes a multidomain protein that functions as a scaffold protein to mediate the mitogen-activated
protein kinase pathways downstream from Ras. This gene product is induced by vitamin D and inhibits apoptosis in
certain cancer cells. It may also play a role in ternary complex assembly of synaptic proteins at the
postsynaptic membrane and coupling of signal transduction to membrane/cytoskeletal remodeling. Multiple
transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Dec 2009)

GeneCards Summary for CNKSR2 Gene:
CNKSR2 (connector enhancer of kinase suppressor of Ras 2) is a protein-coding gene. GO annotations related to this gene include phospholipid binding. An important paralog of this gene is IPCEF1.

UniProtKB/Swiss-Prot: CNKR2_HUMAN, Q8WXI2
Function: May function as an adapter protein or regulator of Ras signaling pathways

Gene Wiki entry for CNKSR2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000023.10  NT_167197.2  NC_018934.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CNKSR2 gene promoter:
         Nkx3-1   Nkx3-1 v4   Pbx1a   Nkx3-1 v1   Cdc5   Nkx3-1 v2   FOXJ2 (long isoform)   Nkx3-1 v3   Sox9   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCNKSR2 promoter sequence
   Search Chromatin IP Primers for CNKSR2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CNKSR2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp22.12   Ensembl cytogenetic band:  Xp22.12   HGNC cytogenetic band: Xp22.12

CNKSR2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CNKSR2 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP021392:  view genomic region     (about GC identifiers)

Start:
21,392,536 bp from pter      End:
21,672,813 bp from pter
Size:
280,278 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CNKR2_HUMAN, Q8WXI2 (See protein sequence)
Recommended Name: Connector enhancer of kinase suppressor of ras 2  
Size: 1034 amino acids; 117535 Da
Subunit: Interacts with RAF1, RAB2L and RAL GTPase proteins
2 PDB 3D structures from and Proteopedia for CNKSR2:
2EAN (3D)        3BS5 (3D)    
Secondary accessions: B4DGR4 B7ZLJ1 B9EG83 E7ESA4 O94976 Q5JPK4 Q5JPN0 Q8WXI1
Alternative splicing: 4 isoforms:  Q8WXI2-1   Q8WXI2-2   Q8WXI2-4   Q8WXI2-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CNKSR2: NX_Q8WXI2

Explore proteomics data for CNKSR2 at MOPED

Post-translational modifications: 

  • Phosphorylated on tyrosine1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CNKSR2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001162118.1  NP_001162119.1  NP_001162120.1  NP_055742.2  

    ENSEMBL proteins: 
     ENSP00000279451   ENSP00000368824   ENSP00000397906   ENSP00000444633  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PLEKH: Pleckstrin homology (PH) domain containing
    SAMD: Sterile alpha motif (SAM) domain containing

    Selected InterPro protein domains (see all 9):
     IPR010599 CNKSR2
     IPR021129 SAM_type1
     IPR001849 Pleckstrin_homology
     IPR011993 PH_like_dom
     IPR013761 SAM/pointed

    Graphical View of Domain Structure for InterPro Entry Q8WXI2

    ProtoNet protein and cluster: Q8WXI2

    4 Blocks protein domains:
    IPB001478 PDZ/DHR/GLGF domain
    IPB001660 Sterile alpha motif SAM
    IPB001849 Pleckstrin-like
    IPB010599 Protein of unknown function DUF1170


    UniProtKB/Swiss-Prot: CNKR2_HUMAN, Q8WXI2
    Similarity: Belongs to the CNKSR family
    Similarity: Contains 1 CRIC domain
    Similarity: Contains 1 DUF1170 domain
    Similarity: Contains 1 PDZ (DHR) domain
    Similarity: Contains 1 PH domain
    Similarity: Contains 1 SAM (sterile alpha motif) domain


    Find genes that share domains with CNKSR2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CNKR2_HUMAN, Q8WXI2
    Function: May function as an adapter protein or regulator of Ras signaling pathways

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0042802identical protein binding IEA--
         
    Find genes that share ontologies with CNKSR2           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CNKSR2
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    miRTarBase miRNAs that target CNKSR2:
    hsa-mir-940 (MIRT036596)

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    Selected qRT-PCR Assays for microRNAs that regulate CNKSR2 (see all 52):
    hsa-miR-3164 hsa-miR-15a hsa-miR-1260b hsa-let-7a-2* hsa-miR-30d hsa-miR-507 hsa-miR-424 hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidCNKSR2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CNKSR2

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CNKR2_HUMAN, Q8WXI2: Cytoplasm. Membrane; Peripheral membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2
    cytoskeleton1
    golgi apparatus1
    plasma membrane1

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005794Golgi apparatus IDA--
    GO:0005886plasma membrane IDA--
    GO:0016020membrane ----
    GO:0043005neuron projection IEA--

    Find genes that share ontologies with CNKSR2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CNKSR2
    Interactions:

        Search GeneGlobe Interaction Network for CNKSR2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CNKSR2 (Q8WXI22, 3 ENSP000003688244) via UniProtKB, MINT, STRING, and/or I2D (see all 56)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LRRC7Q96NW72, 3, ENSP000000353834MINT-1784595 I2D: score=4 STRING: ENSP00000035383
    BRAFP150563, ENSP000002886024I2D: score=2 STRING: ENSP00000288602
    HRASP011123, ENSP000003098454I2D: score=2 STRING: ENSP00000309845
    MOB3BQ86TA13, ENSP000002622444I2D: score=2 STRING: ENSP00000262244
    TNIKQ9UKE53, ENSP000003995114I2D: score=2 STRING: ENSP00000399511
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0009966regulation of signal transduction IEA--

    Find genes that share ontologies with CNKSR2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CNKSR2 (CNKR2)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CNKSR2 gene (4 alternative transcripts): 
    NM_001168647.1  NM_001168648.1  NM_001168649.1  NM_014927.3  

    Unigene Cluster for CNKSR2:

    Connector enhancer of kinase suppressor of Ras 2
    Hs.555917  [show with all ESTs]
    Unigene Representative Sequence: NM_014927
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000279451(uc004czw.3) ENST00000379510 ENST00000480138 ENST00000479158
    ENST00000485012 ENST00000425654(uc004czx.2 uc011mjo.2) ENST00000543067(uc011mjn.2 uc004czy.3)

    miRNA
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    Block miRNA regulation of human, mouse, rat CNKSR2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CNKSR2 (see all 52):
    hsa-miR-3164 hsa-miR-15a hsa-miR-1260b hsa-let-7a-2* hsa-miR-30d hsa-miR-507 hsa-miR-424 hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidCNKSR2 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for CNKSR2
    Predesigned siRNA for gene silencing in human, mouse, rat CNKSR2
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    GenScript: all cDNA clones in your preferred vector (see all 4): CNKSR2 (NM_014927)
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    OriGene qPCR primer pairs and template standards for CNKSR2
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CNKSR2
      QuantiTect SYBR Green Assays in human, mouse, rat CNKSR2
      QuantiFast Probe-based Assays in human, mouse, rat CNKSR2

    Additional mRNA sequence: 

    AB020709.1 AF418269.1 AF418270.1 AK056549.1 AK124258.1 AK294728.1 BC092447.1 BC126121.1 
    BC136289.1 BC143839.1 

    6 DOTS entries:

    DT.408062  DT.210699  DT.95153379  DT.100736664  DT.121288814  DT.427299 

    Selected AceView cDNA sequences (see all 57):

    AF418269 AW468132 F09543 NM_014927 AF418270 CA975859 BM692904 AK056549 
    AB020709 AA081786 AI361550 AA325920 AW237040 T65396 BE702076 AW896402 
    Z40257 BP360548 AI670947 BI489493 BF432843 BP348863 BF510923 F11896 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for CNKSR2    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22
    SP1:                                                                                                                                                
    SP2:                                                                                -                                                               
    SP3:                                                                                                                                                
    SP4:        -                                                                                                                                       


    ECgene alternative splicing isoforms for CNKSR2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CNKSR2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAAGAGACCT
    CNKSR2 Expression
    About this image


    CNKSR2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     NULL (Uncategorized)
             Vascular endothelial growth factor-induced cells
     
     Inner Cell Mass (Early Embryonic Tissues)
             C2a
     
     Brain (Nervous System)
    CNKSR2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CNKSR2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.555917
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CNKSR2 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cnksr21 , 5 connector enhancer of kinase suppressor of Ras 21, 5 93.77(n)1
    98.74(a)1
      X (72.76 cM)5
    2456841  NM_177751.21  NP_808419.11 
     1578214365 
    chicken
    (Gallus gallus)
    Aves CNKSR21 connector enhancer of kinase suppressor of Ras 2 81.88(n)
    90.43(a)
      427997  XM_425567.4  XP_425567.3 
    lizard
    (Anolis carolinensis)
    Reptilia CNKSR26
    connector enhancer of kinase suppressor of Ras 2
    91(a)
    1 ↔ 1
    3(124298513-124477865)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia cnksr21 connector enhancer of kinase suppressor of Ras 2 78.71(n)
    86.37(a)
      100101685  NM_001100211.2  NP_001093681.2 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.262982 Transcribed sequence with weak similarity to protein more 76.55(n)    CD604333.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta cnk6
    connector enhancer of ksr
    17(a)
    1 → many
    2R(13301476-13307104)
    worm
    (Caenorhabditis elegans)
    Secernentea cnk-16
    Protein CNK-1 (cnk-1) mRNA, complete cds
    19(a)
    1 → many
    III(10271257-10278579) WBGene00000564


    ENSEMBL Gene Tree for CNKSR2 (if available)
    TreeFam Gene Tree for CNKSR2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CNKSR2 gene
    IPCEF12  CNKSR32  CNKSR12  
    2 SIMAP similar genes for CNKSR2 using alignment to 2 protein entries:     CNKR2_HUMAN (see all proteins):
    CNKSR3    IPCEF1

    Find genes that share paralogs with CNKSR2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CNKSR2 (see all 3010)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0356814
    A colorectal cancer sample4--see VAR_0356812 R H mis40--------
    rs2007170351,2
    --21304728(+) TACAC-/ATATATA 4 -- us2k10--------
    rs1905475261,2
    --21304777(+) ACACAC/TATATA 4 -- us2k10--------
    rs1838728141,2
    --21304988(+) ACACAC/TATATA 4 -- us2k10--------
    rs1889703501,2
    --21305012(+) ACACAC/TATATA 4 -- us2k10--------
    rs1926811851,2
    --21305383(+) GTCACA/TATATT 4 -- us2k10--------
    rs1844810941,2
    C--21305427(+) GTGTGG/TGGGGG 4 -- us2k10--------
    rs1870734681,2
    --21305443(+) GGTGTC/TGTCAA 4 -- us2k10--------
    rs1392194611,2
    --21305479(+) TTTCTC/GCATCT 4 -- us2k10--------
    rs59514451,2
    C,F,H--21305632(+) GAGTTA/TGCATC 4 -- us2k18Minor allele frequency- T:0.43NS EA NA WA CSA 425

    HapMap Linkage Disequilibrium report for CNKSR2 (21392536 - 21642536 bp, first 250kb of CNKSR2)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for CNKSR2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv273338CNV Insertion20981092
    nsv6830CNV Insertion18451855
    nsv510819CNV Loss20534489

    Human Gene Mutation Database (HGMD): CNKSR2
    Locus Specific Mutation Databases (LSDB): CNKSR2

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CNKSR2
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 300724    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for CNKSR2:
    Neuritis

    Find genes that share disorders with CNKSR2           About GenesLikeMe

    Genetic Association Database (GAD): CNKSR2

    Export disorders for CNKSR2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CNKSR2 gene, integrated from 10 sources (see all 26):
    (articles sorted by number of sources associating them with CNKSR2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (Nature 2005)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Human homologue of Drosophila CNK interacts with Ras effector proteins Raf and Rlf. (PubMed id 14597674)1, 2 Lanigan T.M.... Guan K.-L. (FASEB J. 2003)
    5. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10048485)1, 2 Nagase T.... Ohara O. (DNA Res. 1998)
    6. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (Sci. Signal. 2011)
    7. Genome-wide association study of biochemical traits in Korcula Island, Croatia. (PubMed id 19260141)1 Zemunik T....Rudan I. (Croat. Med. J. 2009)
    8. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (Sci. Signal. 2009)
    9. Defining the human deubiquitinating enzyme interaction landscape. (PubMed id 19615732)1 Sowa M.E....Harper J.W. (Cell 2009)
    10. Large-scale proteomics and phosphoproteomics of urinary exosomes. (PubMed id 19056867)1 Gonzales P.A....Knepper M.A. (J. Am. Soc. Nephrol. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 22866 HGNC: 19701 AceView: CNKSR2 Ensembl:ENSG00000149970 euGenes: HUgn22866
    ECgene: CNKSR2 H-InvDB: CNKSR2

    (According to HUGE)
    About This Section

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    HUGE: KIAA0902

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CNKSR2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for CNKSR2 gene:
    Search GeneIP for patents involving CNKSR2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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