Aliases for CNKSR2 Gene
External Ids for CNKSR2 Gene
Previous GeneCards Identifiers for CNKSR2 Gene
This gene encodes a multidomain protein that functions as a scaffold protein to mediate the mitogen-activated protein kinase pathways downstream from Ras. This gene product is induced by vitamin D and inhibits apoptosis in certain cancer cells. It may also play a role in ternary complex assembly of synaptic proteins at the postsynaptic membrane and coupling of signal transduction to membrane/cytoskeletal remodeling. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009]
GeneCards Summary for CNKSR2 Gene
CNKSR2 (Connector Enhancer Of Kinase Suppressor Of Ras 2) is a Protein Coding gene. Diseases associated with CNKSR2 include Undetermined Early-Onset Epileptic Encephalopathy and Syndromic X-Linked Intellectual Disability. Among its related pathways are Interleukin-3, 5 and GM-CSF signaling and Developmental Biology. GO annotations related to this gene include identical protein binding. An important paralog of this gene is CNKSR1.
UniProtKB/Swiss-Prot for CNKSR2 Gene
May function as an adapter protein or regulator of Ras signaling pathways.