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Aliases for CNKSR2 Gene

Aliases for CNKSR2 Gene

  • Connector Enhancer Of Kinase Suppressor Of Ras 2 2 3
  • CNK2 3 4 6
  • Connector Enhancer Of KSR 2 3 4
  • CNK Homolog Protein 2 3 4
  • KIAA0902 4 6
  • KSR2 3 4
  • Membrane-Associated Guanylate Kinase-Interacting Protein 3
  • Connector Enhancer Of KSR2 3
  • MAGUIN 3

External Ids for CNKSR2 Gene

Summaries for CNKSR2 Gene

Entrez Gene Summary for CNKSR2 Gene

  • This gene encodes a multidomain protein that functions as a scaffold protein to mediate the mitogen-activated protein kinase pathways downstream from Ras. This gene product is induced by vitamin D and inhibits apoptosis in certain cancer cells. It may also play a role in ternary complex assembly of synaptic proteins at the postsynaptic membrane and coupling of signal transduction to membrane/cytoskeletal remodeling. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009]

GeneCards Summary for CNKSR2 Gene

CNKSR2 (Connector Enhancer Of Kinase Suppressor Of Ras 2) is a Protein Coding gene. GO annotations related to this gene include phospholipid binding. An important paralog of this gene is CNKSR1.

UniProtKB/Swiss-Prot for CNKSR2 Gene

  • May function as an adapter protein or regulator of Ras signaling pathways.

Gene Wiki entry for CNKSR2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CNKSR2 Gene

Genomics for CNKSR2 Gene

Genomic Location for CNKSR2 Gene

21,374,414 bp from pter
21,654,695 bp from pter
280,282 bases
Plus strand

Genomic View for CNKSR2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CNKSR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CNKSR2 Gene

Regulatory Elements for CNKSR2 Gene

Proteins for CNKSR2 Gene

  • Protein details for CNKSR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Connector enhancer of kinase suppressor of ras 2
    Protein Accession:
    Secondary Accessions:
    • B4DGR4
    • B7ZLJ1
    • B9EG83
    • E7ESA4
    • O94976
    • Q5JPK4
    • Q5JPN0
    • Q8WXI1

    Protein attributes for CNKSR2 Gene

    1034 amino acids
    Molecular mass:
    117535 Da
    Quaternary structure:
    • Interacts with RAF1, RAB2L and RAL GTPase proteins.

    Three dimensional structures from OCA and Proteopedia for CNKSR2 Gene

    Alternative splice isoforms for CNKSR2 Gene


neXtProt entry for CNKSR2 Gene

Proteomics data for CNKSR2 Gene at MOPED

Post-translational modifications for CNKSR2 Gene

Other Protein References for CNKSR2 Gene

No data available for DME Specific Peptides for CNKSR2 Gene

Domains for CNKSR2 Gene

Gene Families for CNKSR2 Gene

  • PLEKH :Pleckstrin homology (PH) domain containing
  • SAMD :Sterile alpha motif (SAM) domain containing


  • Contains 1 CRIC domain.:
    • Q8WXI2
  • Contains 1 DUF1170 domain.:
    • Q8WXI2
  • Contains 1 PDZ (DHR) domain.:
    • Q8WXI2
  • Contains 1 PH domain.:
    • Q8WXI2
  • Contains 1 SAM (sterile alpha motif) domain.:
    • Q8WXI2
  • Belongs to the CNKSR family.:
    • Q8WXI2
genes like me logo Genes that share domains with CNKSR2: view

Function for CNKSR2 Gene

Molecular function for CNKSR2 Gene

UniProtKB/Swiss-Prot Function: May function as an adapter protein or regulator of Ras signaling pathways.

Gene Ontology (GO) - Molecular Function for CNKSR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0042802 identical protein binding IEA --
genes like me logo Genes that share ontologies with CNKSR2: view

miRNA for CNKSR2 Gene

miRTarBase miRNAs that target CNKSR2

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for CNKSR2 Gene

Localization for CNKSR2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CNKSR2 Gene

Cytoplasm. Membrane; Peripheral membrane protein.

Subcellular locations from

Jensen Localization Image for CNKSR2 Gene COMPARTMENTS Subcellular localization image for CNKSR2 gene
Compartment Confidence
cytosol 2
nucleus 2
cytoskeleton 1
golgi apparatus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CNKSR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm --
GO:0005794 Golgi apparatus IDA --
GO:0005886 plasma membrane IDA --
GO:0016020 membrane --
GO:0043005 neuron projection IEA --
genes like me logo Genes that share ontologies with CNKSR2: view

Pathways for CNKSR2 Gene

SuperPathways for CNKSR2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CNKSR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009966 regulation of signal transduction IEA --
genes like me logo Genes that share ontologies with CNKSR2: view

No data available for Pathways by source for CNKSR2 Gene

Transcripts for CNKSR2 Gene

Unigene Clusters for CNKSR2 Gene

Connector enhancer of kinase suppressor of Ras 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CNKSR2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22
SP2: -
SP4: -

Relevant External Links for CNKSR2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CNKSR2 Gene

mRNA expression in normal human tissues for CNKSR2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CNKSR2 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (7.1), Brain - Frontal Cortex (BA9) (5.6), Brain - Cerebellum (5.6), Brain - Nucleus accumbens (basal ganglia) (4.5), Brain - Anterior cingulate cortex (BA24) (4.5), and Brain - Cortex (4.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CNKSR2 Gene

SOURCE GeneReport for Unigene cluster for CNKSR2 Gene Hs.555917

genes like me logo Genes that share expressions with CNKSR2: view

Orthologs for CNKSR2 Gene

This gene was present in the common ancestor of animals.

Orthologs for CNKSR2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CNKSR2 36
  • 96.36 (n)
  • 95.34 (a)
  • 100 (a)
(Bos Taurus)
Mammalia CNKSR2 36
  • 94.91 (n)
  • 99.42 (a)
  • 97 (a)
(Canis familiaris)
Mammalia CNKSR2 36
  • 95.04 (n)
  • 99.32 (a)
  • 99 (a)
(Mus musculus)
Mammalia Cnksr2 36
  • 93.77 (n)
  • 98.74 (a)
Cnksr2 16
Cnksr2 37
  • 99 (a)
(Monodelphis domestica)
Mammalia CNKSR2 37
  • 94 (a)
(Ornithorhynchus anatinus)
Mammalia CNKSR2 37
  • 88 (a)
(Rattus norvegicus)
Mammalia Cnksr2 36
  • 94.02 (n)
  • 99.13 (a)
(Gallus gallus)
Aves CNKSR2 36
  • 81.88 (n)
  • 90.43 (a)
  • 91 (a)
(Anolis carolinensis)
Reptilia CNKSR2 37
  • 91 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cnksr2 36
  • 78.71 (n)
  • 86.37 (a)
(Danio rerio)
Actinopterygii cnksr2a 36
  • 68.82 (n)
  • 78.18 (a)
cnksr2a 37
  • 76 (a)
cnksr2b 37
  • 71 (a)
Dr.26298 36
fruit fly
(Drosophila melanogaster)
Insecta cnk 37
  • 17 (a)
(Caenorhabditis elegans)
Secernentea cnk-1 37
  • 19 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 39 (a)
Species with no ortholog for CNKSR2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CNKSR2 Gene

Gene Tree for CNKSR2 (if available)
Gene Tree for CNKSR2 (if available)

Paralogs for CNKSR2 Gene

Paralogs for CNKSR2 Gene

Selected SIMAP similar genes for CNKSR2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CNKSR2: view

Variants for CNKSR2 Gene

Sequence variations from dbSNP and Humsavar for CNKSR2 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs921841 -- 21,374,115(-) CAGAG(C/T)CCGGG upstream-variant-2KB
rs921842 -- 21,374,106(-) GGGTC(A/G)GTCAA upstream-variant-2KB
rs993265 -- 21,513,880(-) aatta(A/G)aaaat intron-variant
rs993755 -- 21,582,424(+) TCTTA(G/T)TGCCA intron-variant
rs1184767 -- 21,520,616(+) ATTAT(C/T)TGGAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CNKSR2 Gene

Variant ID Type Subtype PubMed ID
nsv510819 CNV Loss 20534489
esv273338 CNV Insertion 20981092
nsv6830 CNV Insertion 18451855

Relevant External Links for CNKSR2 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)
Locus Specific Mutation Databases (LSDB)

Disorders for CNKSR2 Gene

(1) University of Copenhagen DISEASES for CNKSR2 Gene

Relevant External Links for CNKSR2

Genetic Association Database (GAD)
genes like me logo Genes that share disorders with CNKSR2: view

No data available for UniProtKB/Swiss-Prot for CNKSR2 Gene

Publications for CNKSR2 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4
  3. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10048485) Nagase T. … Ohara O. (DNA Res. 1998) 3 4
  4. Human homologue of Drosophila CNK interacts with Ras effector proteins Raf and Rlf. (PMID: 14597674) Lanigan T.M. … Guan K.-L. (FASEB J. 2003) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for CNKSR2 Gene

Sources for CNKSR2 Gene

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