Aliases for CNKSR2 Gene
External Ids for CNKSR2 Gene
Previous GeneCards Identifiers for CNKSR2 Gene
This gene encodes a multidomain protein that functions as a scaffold protein to mediate the mitogen-activated protein kinase pathways downstream from Ras. This gene product is induced by vitamin D and inhibits apoptosis in certain cancer cells. It may also play a role in ternary complex assembly of synaptic proteins at the postsynaptic membrane and coupling of signal transduction to membrane/cytoskeletal remodeling. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009]
GeneCards Summary for CNKSR2 Gene
CNKSR2 (Connector Enhancer Of Kinase Suppressor Of Ras 2) is a Protein Coding gene. Diseases associated with CNKSR2 include Undetermined Early-Onset Epileptic Encephalopathy and X-Linked Non-Specific Intellectual Disability. Among its related pathways are RET signaling and Oncogenic MAPK signaling. GO annotations related to this gene include identical protein binding. An important paralog of this gene is CNKSR3.
UniProtKB/Swiss-Prot for CNKSR2 Gene
May function as an adapter protein or regulator of Ras signaling pathways.