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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CNKSR1 Gene

protein-coding   GIFtS: 52
GCID: GC01P026503

connector enhancer of kinase suppressor of Ras 1

 Explore 3 diseases affiliated with
CNKSR1 via our new
 Human Malady Compendium 
Biological research products
for CNKSR1
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Connector Enhancer Of Kinase Suppressor Of Ras 11 2     Connector Enhancer Of KSR 12 3
CNK11 2 3     CNK Homolog Protein 12 3
CNK1 2     HCNK11
KSR1 2     Connector Enhancer Of KSR-Like3

External Ids:    HGNC: 197001   Entrez Gene: 102562   Ensembl: ENSG000001426757   OMIM: 6032725   UniProtKB: Q969H43   
ORGUL members:         
NONCODE:n406454    

Export aliases for CNKSR1 gene to outside databases

Previous GC identifers: GC01P026109 GC01P026188 GC01P026376 GC01P024758


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CNKSR1:
This gene is a necessary element in receptor tyrosine kinase pathways, possibly as a tyrosine phosphorylation target.
It is involved in regulation of RAF in the MAPK pathway and may also play a role in a MAPK-independent pathway.
(provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CNKR1_HUMAN, Q969H4
Function: May function as an adapter protein or regulator of Ras signaling pathways

Gene Wiki entry for CNKSR1


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_004610.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CNKSR1 gene promoter:
         HEN1   AP-1   ATF-2   c-Jun   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCNKSR1 promoter sequence
   Search SABiosciences Chromatin IP Primers for CNKSR1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CNKSR1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.11   Ensembl cytogenetic band:  1p36.11   HGNC cytogenetic band: 1p35.3

CNKSR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CNKSR1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P026503:  view genomic region     (about GC identifiers)

Start:
26,503,894 bp from pter      End:
26,516,377 bp from pter
Size:
12,484 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CNKR1_HUMAN, Q969H4 (See protein sequence)
Recommended Name: Connector enhancer of kinase suppressor of ras 1  
Size: 720 amino acids; 79706 Da
Subunit: Interacts with RHO and RALGDS
Subcellular location: Cytoplasm (By similarity). Membrane; Peripheral membrane protein (By similarity)
1 PDB 3D structure from and Proteopedia for CNKSR1:
1WWV (3D)    
Secondary accessions: B1AMW9 O95381
Alternative splicing: 2 isoforms:  Q969H4-1   Q969H4-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CNKSR1: NX_Q969H4

Post-translational modifications:

  • Phosphorylated on tyrosine1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q969H4

  • CNKSR1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_006305.2  
    ENSEMBL proteins: 
     ENSP00000354609   ENSP00000432057   ENSP00000363371   ENSP00000437038   ENSP00000435880  
     ENSP00000431817   ENSP00000434047  

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    Uscn Proteins for CNKSR1

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS9814705
    GO:0005911cell-cell junction TAS9814705
    GO:0005938cell cortex IDA15075335


    CNKSR1 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    CNKSR1 for domains           About GeneDecksing

    5/8 InterPro domains/families (see all 8):
     IPR021129 SAM_type1
     IPR001849 Pleckstrin_homology
     IPR011993 PH_like_dom
     IPR013761 SAM/pointed
     IPR001660 SAM

    Graphical View of Domain Structure for InterPro Entry Q969H4

    ProtoNet protein and cluster: Q969H4

    3 Blocks protein families:
    IPB001660 Sterile alpha motif SAM
    IPB001849 Pleckstrin-like
    IPB011510 Sterile alpha motif homology 2


    UniProtKB/Swiss-Prot: CNKR1_HUMAN, Q969H4
    Similarity: Belongs to the CNKSR family
    Similarity: Contains 1 CRIC domain
    Similarity: Contains 1 PDZ (DHR) domain
    Similarity: Contains 1 PH domain
    Similarity: Contains 1 SAM (sterile alpha motif) domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: CNKR1_HUMAN, Q969H4
    Function: May function as an adapter protein or regulator of Ras signaling pathways

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    Inhib. RNA
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    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI15670823
    GO:0005543phospholipid binding IEA--
    GO:0016301kinase activity ----
    GO:0030674protein binding, bridging IDA14749388


    CNKSR1 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for CNKSR1:
     Synthetic lethal with c-Myc af 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CNKSR1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 20)

    5/22 Interacting proteins for CNKSR1 (Q969H41, 2, 3 ENSP000003546094) via UniProtKB, MINT, STRING, and/or I2D (see all 22)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RHOAP615861, 2, 3, ENSP000004001754EBI-741671,EBI-446668 MINT-56522 MINT-56518 MINT-56516 MINT-56519 I2D: score=5 STRING: ENSP00000400175
    CYTH3O437392, 3, ENSP000002970444MINT-66188 I2D: score=5 STRING: ENSP00000297044
    SMAD4Q134852, 3MINT-61978 I2D: score=3 
    RAF1P040492, 3, ENSP000002518494MINT-56513 I2D: score=4 STRING: ENSP00000251849
    RASSF1Q9NS232, 3, ENSP000003495474MINT-56515 I2D: score=4 STRING: ENSP00000349547
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007169transmembrane receptor protein tyrosine kinase signaling pathway TAS9814705
    GO:0007265Ras protein signal transduction IPI14749388
    GO:0007266Rho protein signal transduction IPI14749388


    CNKSR1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CNKSR1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CNKSR1
    3 Novoseek chemical compound relationships for CNKSR1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ceramide 63.7 4 9531568 (1), 9804808 (1), 12676512 (1)
    threonine 24.3 1 11134016 (1)
    tyrosine 21.1 1 8521512 (1)

    Search CenterWatch for drugs/clinical trials and news about CNKSR1 / CNKR1 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CNKSR1 gene: 
    NM_006314.2  

    Unigene Cluster for CNKSR1:

    Connector enhancer of kinase suppressor of Ras 1
    Hs.16232  [show with all ESTs]
    Unigene Representative Sequence: BC012797
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000361530(uc010oex.1 uc001blm.4 uc009vsd.3 uc009vse.3)
    ENST00000481077 ENST00000480348 ENST00000465415 ENST00000374253(uc001bln.4)
    ENST00000525687 ENST00000482227 ENST00000531191 ENST00000524529 ENST00000531150
    ENST00000528001 ENST00000528281 ENST00000480617 ENST00000484874

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    Additional cDNA sequence: 

    AB209335.1 AF100153.1 AK001900.1 AK222817.1 AK222904.1 AK292646.1 AK296814.1 AK302056.1 
    BC011604.2 BC012797.2 BT006900.1 NR_023345.1 

    10 DOTS entries:

    DT.412818  DT.95269681  DT.95069868  DT.100806032  DT.100721147  DT.100778809  DT.121348186  DT.100683003 
    DT.121348185  DT.99975514 

    24/99 AceView cDNA sequences (see all 99):

    BM750903 BE730887 AW961213 T24751 NM_006314 BI916418 CB854293 CA433801 
    BU685413 CK824807 AF100153 BX363940 BT006900 BE140561 BG479915 BC011604 
    BU944084 BX280341 BC012797 AW299295 BM918431 CR624234 R48382 BM271803 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for CNKSR1 (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17a ·
    SP1:                          -                 -     -                                         -                                         -                     
    SP2:                          -                 -     -                                                                                   -                     
    SP3:                          -                 -     -                                         -                                         -                     
    SP4:                                                                                            -           -                             -                     
    SP5:                    -     -                 -     -                                                                                                         

    ExUns: 17b ^ 18 ^ 19 ^ 20 ^ 21
    SP1:                              
    SP2:                              
    SP3:                              
    SP4:                              
    SP5:                              


    ECgene alternative splicing isoforms for CNKSR1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CNKSR1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AGGGCTACTT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See CNKSR1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CNKSR1

    SOURCE GeneReport for Unigene cluster: Hs.16232
        SABiosciences Custom PCR Arrays for CNKSR1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CNKSR1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for CNKSR1 gene from 5/17 species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves CNKSR11 connector enhancer of kinase suppressor of Ras 1 58.28(n)
    50.15(a)
      419548  XM_417698.3  XP_417698.3 
    lizard
    (Anolis carolinensis)
    Reptilia CNKSR16
    --
    43(a)
    1 ↔ 1
    GL343480.1(390850-423416)
    zebrafish
    (Danio rerio)
    Actinopterygii cnksr11 connector enhancer of kinase suppressor of Ras 1 52.34(n)
    40.83(a)
      402957  NM_205659.1  NP_991222.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta cnk6
    connector enhancer of ksr
    9(a)
    possible ortholog
    2R(13301476-13307104)
    worm
    (Caenorhabditis elegans)
    Secernentea cnk-16
    Connector/eNhancer of KSR family member (cnk-1)
    13(a)
    possible ortholog
    III(10271166-10278488)


    ENSEMBL Gene Tree for CNKSR1 (if available)
    TreeFam Gene Tree for CNKSR1 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CNKSR1 gene
    IPCEF12  CNKSR32  CNKSR22  
    1 SIMAP similar gene for CNKSR1 using alignment to 7 protein entries:     CNKR1_HUMAN (see all proteins):
    CNKSR3

    CNKSR1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/354 NCBI SNPs in CNKSR1 are shown (see all 354    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1998739671,2
    C--26502149(+) CCTGTC/TTNNNN 2 -- us2k10--------
    rs343121861,2
    C--26502150(+) TTTTTT/-TTTTT 2 -- us2k11Minor allele frequency- -:0.00NA 2
    rs1908188791,2
    --26502229(+) CTGCAA/CGCTCT 2 -- us2k10--------
    rs1446273721,2
    --26502294(+) CAGGCA/GCCCGC 2 -- us2k10--------
    rs749673111,2
    C,F,--26502404(+) CGATTA/TTAGGC 2 -- us2k11Minor allele frequency- T:0.04WA 118
    rs1815585371,2
    --26502414(+) CGTGAA/GCCACC 2 -- us2k10--------
    rs21543681,2
    C,F,O,H,--26502466(-) CTTACA/GTATTG 2 -- us2k110Minor allele frequency- G:0.37EA NA NS 756
    rs796165631,2
    F,--26502567(+) CTTTCG/AGCCAG 2 -- us2k11Minor allele frequency- A:0.06WA 118
    rs1478643321,2
    --26502592(+) GTAAAC/TACATA 2 -- us2k10--------
    rs1140344641,2
    F,--26502655(+) GGGTGG/ACTTTG 2 -- us2k11Minor allele frequency- A:0.03WA 118

    HapMap Linkage Disequilibrium report for CNKSR1 (26503894 - 26516377 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for CNKSR1: --
    Human Gene Mutation Database (HGMD): CNKSR1

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    CNKSR1 for disorders           About GeneDecksing

    OMIM gene information: 603272    OMIM disorders: --

    3 diseases for CNKSR1:    About MalaCards
    endometriosis    tuberculosis    mycobacterium tuberculosis


    Export disorders for CNKSR1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CNKSR1 gene, integrated from 9 sources (see all 42):
    (articles sorted by number of sources associating them with CNKSR1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. CNK, a RAF-binding multidomain protein required for RAS signaling. (PubMed id 9814705)1, 2, 3, 9 Therrien M.... Rubin G.M. (1998)
    2. Human CNK1 acts as a scaffold protein, linking Rho and Ras signal transduction pathways. (PubMed id 14749388)1, 2, 9 Jaffe A.B.... Hall A. (2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Association of CNK1 with Rho guanine nucleotide exchange factors controls signaling specificity downstream of Rho. (PubMed id 15753034)1, 9 Jaffe A.B....Schmidt A. (2005)
    5. Bioluminescence resonance energy transfer identify scaffold protein CNK1 interactions in intact cells. (PubMed id 15670823)1, 9 Lopez-Ilasaca M.A....Xavier R.J. (2005)
    6. Carbohydrate-specific signaling through the DC-SIGN s ignalosome tailors immunity to Mycobacterium tuberculosis, HIV-1 and Helicobact er pylori. (PubMed id 19718030)1, 9 Gringhuis S.I....Geijtenbeek T.B. (2009)
    7. CNK1 and other scaffolds for Akt/FoxO signaling. (PubMed id 21320536)1 Fritz R.D. and Radziwill G. (2011)
    8. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
    9. CNK1 promotes invasion of cancer cells through NF-kap paB-dependent signaling. (PubMed id 20197385)1 Fritz R.D. and Radziwill G. (2010)
    10. CNK1 is a novel Akt interaction partner that promotes cell proliferation through the Akt-FoxO signalling axis. (PubMed id 20383191)1 Fritz R.D....Radziwill G. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10256 HGNC: 19700 AceView: CNKSR1 Ensembl:ENSG00000142675 euGenes: HUgn10256
    ECgene: CNKSR1 H-InvDB: CNKSR1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CNKSR1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CNKSR1 gene:
    Search GeneIP for patents involving CNKSR1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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