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Aliases for CNKSR1 Gene

Aliases for CNKSR1 Gene

  • Connector Enhancer Of Kinase Suppressor Of Ras 1 2 3 5
  • Connector Enhancer Of KSR-Like 3 4
  • Connector Enhancer Of KSR 1 3 4
  • CNK Homolog Protein 1 3 4
  • CNK1 3 4
  • HCNK1 4
  • CNK 3

External Ids for CNKSR1 Gene

Previous GeneCards Identifiers for CNKSR1 Gene

  • GC01P026109
  • GC01P026376
  • GC01P026503
  • GC01P024758

Summaries for CNKSR1 Gene

Entrez Gene Summary for CNKSR1 Gene

  • This gene encodes a protein containing several motifs involved in protein-protein interaction, including PDZ, PH (Pleckstrin homology), and SAM (sterile alpha motif) domains. The encoded protein acts as a scaffold component for receptor tyrosine kinase signaling and may mediate crosstalk between different signaling pathways. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

GeneCards Summary for CNKSR1 Gene

CNKSR1 (Connector Enhancer Of Kinase Suppressor Of Ras 1) is a Protein Coding gene. Among its related pathways are RET signaling and Immune System. GO annotations related to this gene include kinase activity and protein binding, bridging. An important paralog of this gene is CNKSR2.

UniProtKB/Swiss-Prot for CNKSR1 Gene

  • May function as an adapter protein or regulator of Ras signaling pathways.

Gene Wiki entry for CNKSR1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CNKSR1 Gene

Genomics for CNKSR1 Gene

Regulatory Elements for CNKSR1 Gene

Enhancers for CNKSR1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F026168 0.5 ENCODE 50.2 -7.4 -7376 2.5 HDGF CREB3L1 ARID4B SIN3A DMAP1 ZNF2 ZNF143 FOS ZNF263 SP3 CNKSR1 FAM110D ENSG00000236782 ZNF593
GH01F026200 1.2 FANTOM5 Ensembl ENCODE 42.1 +24.3 24273 2.6 HDGF PKNOX1 ATF1 ARNT CREB3L1 GATA2 KDM4B NCOA1 REST SMARCA4 CNKSR1 TRIM63 FAM110D ZNF593 CD52 MTFR1L PDIK1L HMGN2 LOC101928303 CATSPER4
GH01F026163 0.9 Ensembl ENCODE 40.9 -12.8 -12760 1.9 HDAC1 ATF1 KLF17 RAD21 YY1 ZNF121 GLIS2 SCRT2 CREM SP3 CNKSR1 FAM110D ENSG00000282872
GH01F026176 0.7 ENCODE 18.8 +0.5 467 2.5 ELF3 HDAC1 PKNOX1 ARID4B GATA2 THAP11 KAT8 PBX2 GLIS1 ETV4 CNKSR1 TRIM63 CATSPER4
GH01F026190 0.4 ENCODE 15.4 +13.1 13101 0.4 CTCF ESRRA TEAD4 ZIC2 RAD21 GLIS2 SMC3 NR2F6 ZNF263 NR2F1 CNKSR1 CATSPER4
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around CNKSR1 on UCSC Golden Path with GeneCards custom track

Promoters for CNKSR1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001742983 397 801 ELF3 PKNOX1 ARID4B GATA2 THAP11 KAT8 PBX2 ETV4 KDM1A BCOR

Genomic Location for CNKSR1 Gene

Chromosome:
1
Start:
26,177,403 bp from pter
End:
26,189,886 bp from pter
Size:
12,484 bases
Orientation:
Plus strand

Genomic View for CNKSR1 Gene

Genes around CNKSR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CNKSR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CNKSR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CNKSR1 Gene

Proteins for CNKSR1 Gene

  • Protein details for CNKSR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q969H4-CNKR1_HUMAN
    Recommended name:
    Connector enhancer of kinase suppressor of ras 1
    Protein Accession:
    Q969H4
    Secondary Accessions:
    • B1AMW9
    • O95381

    Protein attributes for CNKSR1 Gene

    Size:
    720 amino acids
    Molecular mass:
    79706 Da
    Quaternary structure:
    • Interacts with RHO and RALGDS.

    Three dimensional structures from OCA and Proteopedia for CNKSR1 Gene

    Alternative splice isoforms for CNKSR1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CNKSR1 Gene

Post-translational modifications for CNKSR1 Gene

No data available for DME Specific Peptides for CNKSR1 Gene

Domains & Families for CNKSR1 Gene

Graphical View of Domain Structure for InterPro Entry

Q969H4

UniProtKB/Swiss-Prot:

CNKR1_HUMAN :
  • Contains 1 CRIC domain.
  • Belongs to the CNKSR family.
Domain:
  • Contains 1 CRIC domain.
  • Contains 1 PDZ (DHR) domain.
  • Contains 1 PH domain.
  • Contains 1 SAM (sterile alpha motif) domain.
Family:
  • Belongs to the CNKSR family.
genes like me logo Genes that share domains with CNKSR1: view

Function for CNKSR1 Gene

Molecular function for CNKSR1 Gene

UniProtKB/Swiss-Prot Function:
May function as an adapter protein or regulator of Ras signaling pathways.

Gene Ontology (GO) - Molecular Function for CNKSR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0016301 kinase activity IEA --
GO:0030674 protein binding, bridging IDA 14749388
genes like me logo Genes that share ontologies with CNKSR1: view
genes like me logo Genes that share phenotypes with CNKSR1: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CNKSR1 Gene

Localization for CNKSR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CNKSR1 Gene

Cytoplasm. Membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CNKSR1 Gene COMPARTMENTS Subcellular localization image for CNKSR1 gene
Compartment Confidence
cytosol 4
plasma membrane 4
nucleus 3
cytoskeleton 2
golgi apparatus 2

Gene Ontology (GO) - Cellular Components for CNKSR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane TAS 9814705
GO:0005911 cell-cell junction TAS 9814705
GO:0005938 cell cortex IDA 15075335
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with CNKSR1: view

Pathways & Interactions for CNKSR1 Gene

SuperPathways for CNKSR1 Gene

SuperPathway Contained pathways
1 RET signaling
2 ERK Signaling
3 Developmental Biology
4 Cytokine Signaling in Immune system
5 HIV Life Cycle
.45
genes like me logo Genes that share pathways with CNKSR1: view

Pathways by source for CNKSR1 Gene

SIGNOR curated interactions for CNKSR1 Gene

Activates:

Gene Ontology (GO) - Biological Process for CNKSR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway TAS 9814705
GO:0007265 Ras protein signal transduction IPI 14749388
GO:0007266 Rho protein signal transduction IPI 14749388
GO:0016310 phosphorylation IEA --
genes like me logo Genes that share ontologies with CNKSR1: view

Drugs & Compounds for CNKSR1 Gene

(3) Drugs for CNKSR1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with CNKSR1: view

Transcripts for CNKSR1 Gene

Unigene Clusters for CNKSR1 Gene

Connector enhancer of kinase suppressor of Ras 1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CNKSR1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17a ·
SP1: - - - - -
SP2: - - - -
SP3: - - - - -
SP4: - - -
SP5: - - - -
SP6: - -
SP7:
SP8:
SP9: -

ExUns: 17b ^ 18 ^ 19 ^ 20 ^ 21
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for CNKSR1 Gene

GeneLoc Exon Structure for
CNKSR1
ECgene alternative splicing isoforms for
CNKSR1

Expression for CNKSR1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CNKSR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CNKSR1 Gene

This gene is overexpressed in Muscle - Skeletal (x7.2).

Protein differential expression in normal tissues from HIPED for CNKSR1 Gene

This gene is overexpressed in Frontal cortex (50.9), Placenta (11.6), and Bone marrow mesenchymal stem cell (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CNKSR1 Gene



Protein tissue co-expression partners for CNKSR1 Gene

NURSA nuclear receptor signaling pathways regulating expression of CNKSR1 Gene:

CNKSR1

SOURCE GeneReport for Unigene cluster for CNKSR1 Gene:

Hs.16232
genes like me logo Genes that share expression patterns with CNKSR1: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for CNKSR1 Gene

Orthologs for CNKSR1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CNKSR1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CNKSR1 34
  • 99.1 (n)
dog
(Canis familiaris)
Mammalia CNKSR1 34 35
  • 85.13 (n)
cow
(Bos Taurus)
Mammalia -- 35
  • 85 (a)
OneToMany
LOC617552 34
  • 83.22 (n)
-- 35
  • 77 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Cnksr1 34 16 35
  • 81.22 (n)
rat
(Rattus norvegicus)
Mammalia Cnksr1 34
  • 80.2 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CNKSR1 35
  • 73 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CNKSR1 35
  • 52 (a)
OneToOne
chicken
(Gallus gallus)
Aves CNKSR1 34 35
  • 62.8 (n)
lizard
(Anolis carolinensis)
Reptilia CNKSR1 35
  • 45 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cnksr1 34
  • 53.84 (n)
zebrafish
(Danio rerio)
Actinopterygii cnksr1 34 35
  • 54.71 (n)
fruit fly
(Drosophila melanogaster)
Insecta cnk 35
  • 11 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea cnk-1 35
  • 16 (a)
OneToMany
Species where no ortholog for CNKSR1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CNKSR1 Gene

ENSEMBL:
Gene Tree for CNKSR1 (if available)
TreeFam:
Gene Tree for CNKSR1 (if available)

Paralogs for CNKSR1 Gene

Paralogs for CNKSR1 Gene

(1) SIMAP similar genes for CNKSR1 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with CNKSR1: view

Variants for CNKSR1 Gene

Sequence variations from dbSNP and Humsavar for CNKSR1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs140685957 Uncertain significance 26,180,836(+) TGATG(A/G/T)CCTCT upstream-variant-2KB, reference, missense, utr-variant-5-prime
rs879255394 Benign 26,183,826(+) CCCCC(-/C)ACAGG reference, frameshift-variant
rs1045102 -- 26,189,358(+) GTGGA(A/T)GGAGC upstream-variant-2KB, reference, missense
rs1045105 -- 26,189,465(+) CCCCC(A/C)ACTCC upstream-variant-2KB, reference, missense
rs111403374 -- 26,179,408(+) GAGGA(A/T)TAGCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CNKSR1 Gene

Variant ID Type Subtype PubMed ID
esv3577792 CNV loss 25503493
nsv1002191 CNV gain 25217958

Variation tolerance for CNKSR1 Gene

Residual Variation Intolerance Score: 77.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.60; 72.47% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CNKSR1 Gene

Human Gene Mutation Database (HGMD)
CNKSR1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CNKSR1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CNKSR1 Gene

Disorders for CNKSR1 Gene

Relevant External Links for CNKSR1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CNKSR1

No disorders were found for CNKSR1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CNKSR1 Gene

Publications for CNKSR1 Gene

  1. CNK, a RAF-binding multidomain protein required for RAS signaling. (PMID: 9814705) Therrien M. … Rubin G.M. (Cell 1998) 2 3 4 22 64
  2. Human CNK1 acts as a scaffold protein, linking Rho and Ras signal transduction pathways. (PMID: 14749388) Jaffe A.B. … Hall A. (Mol. Cell. Biol. 2004) 3 4 22 64
  3. Carbohydrate-specific signaling through the DC-SIGN signalosome tailors immunity to Mycobacterium tuberculosis, HIV-1 and Helicobacter pylori. (PMID: 19718030) Gringhuis S.I. … Geijtenbeek T.B. (Nat. Immunol. 2009) 3 22 64
  4. CNK and HYP form a discrete dimer by their SAM domains to mediate RAF kinase signaling. (PMID: 18287031) Rajakulendran T. … Sicheri F. (Proc. Natl. Acad. Sci. U.S.A. 2008) 3 22 64
  5. KSR and CNK: two scaffolds regulating RAS-mediated RAF activation. (PMID: 17496912) ClapAcron A. … Therrien M. (Oncogene 2007) 3 22 64

Products for CNKSR1 Gene

Sources for CNKSR1 Gene

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