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Aliases for CNKSR1 Gene

Aliases for CNKSR1 Gene

  • Connector Enhancer Of Kinase Suppressor Of Ras 1 2 3
  • Connector Enhancer Of KSR 1 3 4
  • CNK Homolog Protein 1 3 4
  • CNK1 3 4
  • Connector Enhancer Of KSR-Like 4
  • HCNK1 4
  • CNK 3

External Ids for CNKSR1 Gene

Previous GeneCards Identifiers for CNKSR1 Gene

  • GC01P026109
  • GC01P026376
  • GC01P026503
  • GC01P024758

Summaries for CNKSR1 Gene

Entrez Gene Summary for CNKSR1 Gene

  • This gene encodes a protein containing several motifs involved in protein-protein interaction, including PDZ, PH (Pleckstrin homology), and SAM (sterile alpha motif) domains. The encoded protein acts as a scaffold component for receptor tyrosine kinase signaling and may mediate crosstalk between different signaling pathways. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

GeneCards Summary for CNKSR1 Gene

CNKSR1 (Connector Enhancer Of Kinase Suppressor Of Ras 1) is a Protein Coding gene. Among its related pathways are ERK Signaling and ERK Signaling. GO annotations related to this gene include phospholipid binding and protein binding, bridging. An important paralog of this gene is IPCEF1.

UniProtKB/Swiss-Prot for CNKSR1 Gene

  • May function as an adapter protein or regulator of Ras signaling pathways

Gene Wiki entry for CNKSR1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CNKSR1 Gene

Genomics for CNKSR1 Gene

Regulatory Elements for CNKSR1 Gene

Genomic Location for CNKSR1 Gene

Start:
26,173,472 bp from pter
End:
26,189,886 bp from pter
Size:
16,415 bases
Orientation:
Plus strand

Genomic View for CNKSR1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CNKSR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CNKSR1 Gene

Proteins for CNKSR1 Gene

  • Protein details for CNKSR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q969H4-CNKR1_HUMAN
    Recommended name:
    Connector enhancer of kinase suppressor of ras 1
    Protein Accession:
    Q969H4
    Secondary Accessions:
    • B1AMW9
    • O95381

    Protein attributes for CNKSR1 Gene

    Size:
    720 amino acids
    Molecular mass:
    79706 Da
    Quaternary structure:
    • Interacts with RHO and RALGDS.

    Three dimensional structures from OCA and Proteopedia for CNKSR1 Gene

    Alternative splice isoforms for CNKSR1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CNKSR1 Gene

Proteomics data for CNKSR1 Gene at MOPED

Post-translational modifications for CNKSR1 Gene

No data available for DME Specific Peptides for CNKSR1 Gene

Domains for CNKSR1 Gene

Gene Families for CNKSR1 Gene

HGNC:
  • PLEKH :Pleckstrin homology (PH) domain containing
  • SAMD :Sterile alpha motif (SAM) domain containing

Graphical View of Domain Structure for InterPro Entry

Q969H4

UniProtKB/Swiss-Prot:

CNKR1_HUMAN :
  • Q969H4
Domain:
  • Contains 1 CRIC domain.
  • Contains 1 PDZ (DHR) domain.
  • Contains 1 PH domain.
  • Contains 1 SAM (sterile alpha motif) domain.
Family:
  • Belongs to the CNKSR family.
genes like me logo Genes that share domains with CNKSR1: view

Function for CNKSR1 Gene

Molecular function for CNKSR1 Gene

UniProtKB/Swiss-Prot Function: May function as an adapter protein or regulator of Ras signaling pathways

Gene Ontology (GO) - Molecular Function for CNKSR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0016301 kinase activity --
GO:0030674 protein binding, bridging IDA 14749388
genes like me logo Genes that share ontologies with CNKSR1: view

Phenotypes for CNKSR1 Gene

GenomeRNAi human phenotypes for CNKSR1:
genes like me logo Genes that share phenotypes with CNKSR1: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CNKSR1 Gene

Localization for CNKSR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CNKSR1 Gene

Cytoplasm. Membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CNKSR1 Gene COMPARTMENTS Subcellular localization image for CNKSR1 gene
Compartment Confidence
plasma membrane 4
cytosol 3
nucleus 3

Gene Ontology (GO) - Cellular Components for CNKSR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS 9814705
GO:0005911 cell-cell junction TAS 9814705
GO:0005938 cell cortex IDA 15075335
genes like me logo Genes that share ontologies with CNKSR1: view

Pathways for CNKSR1 Gene

genes like me logo Genes that share pathways with CNKSR1: view

Pathways by source for CNKSR1 Gene

3 Qiagen pathways for CNKSR1 Gene

Gene Ontology (GO) - Biological Process for CNKSR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway TAS 9814705
GO:0007265 Ras protein signal transduction IPI 14749388
GO:0007266 Rho protein signal transduction IPI 14749388
GO:0016310 phosphorylation --
genes like me logo Genes that share ontologies with CNKSR1: view

Compounds for CNKSR1 Gene

(3) Novoseek inferred chemical compound relationships for CNKSR1 Gene

Compound -log(P) Hits PubMed IDs
ceramide 63.7 3
threonine 24.3 1
tyrosine 21.1 1
genes like me logo Genes that share compounds with CNKSR1: view

Transcripts for CNKSR1 Gene

Unigene Clusters for CNKSR1 Gene

Connector enhancer of kinase suppressor of Ras 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CNKSR1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17a ·
SP1: - - - - -
SP2: - - - -
SP3: - - - - -
SP4: - - -
SP5: - - - -
SP6: - -
SP7:
SP8:
SP9: -

ExUns: 17b ^ 18 ^ 19 ^ 20 ^ 21
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for CNKSR1 Gene

GeneLoc Exon Structure for
CNKSR1
ECgene alternative splicing isoforms for
CNKSR1

Expression for CNKSR1 Gene

mRNA expression in normal human tissues for CNKSR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CNKSR1 Gene

This gene is overexpressed in Muscle - Skeletal (7.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CNKSR1 Gene

SOURCE GeneReport for Unigene cluster for CNKSR1 Gene Hs.16232

genes like me logo Genes that share expressions with CNKSR1: view

No data available for mRNA Expression by UniProt/SwissProt for CNKSR1 Gene

Orthologs for CNKSR1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CNKSR1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CNKSR1 35
  • 99.1 (n)
  • 98.35 (a)
cow
(Bos Taurus)
Mammalia -- 36
  • 85 (a)
OneToMany
-- 36
  • 77 (a)
OneToMany
LOC617552 35
  • 83.22 (n)
  • 78.98 (a)
dog
(Canis familiaris)
Mammalia CNKSR1 35
  • 85.13 (n)
  • 79.52 (a)
CNKSR1 36
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cnksr1 35
  • 81.22 (n)
  • 78.6 (a)
Cnksr1 16
Cnksr1 36
  • 77 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CNKSR1 36
  • 52 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CNKSR1 36
  • 73 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cnksr1 35
  • 80.2 (n)
  • 77.6 (a)
chicken
(Gallus gallus)
Aves CNKSR1 35
  • 62.8 (n)
  • 53.78 (a)
CNKSR1 36
  • 37 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CNKSR1 36
  • 45 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cnksr1 35
  • 53.84 (n)
  • 47.1 (a)
zebrafish
(Danio rerio)
Actinopterygii cnksr1 35
  • 54.71 (n)
  • 44.14 (a)
cnksr1 36
  • 34 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta cnk 36
  • 11 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea cnk-1 36
  • 16 (a)
OneToMany
Species with no ortholog for CNKSR1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CNKSR1 Gene

ENSEMBL:
Gene Tree for CNKSR1 (if available)
TreeFam:
Gene Tree for CNKSR1 (if available)

Paralogs for CNKSR1 Gene

Paralogs for CNKSR1 Gene

Selected SIMAP similar genes for CNKSR1 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with CNKSR1: view

Variants for CNKSR1 Gene

Sequence variations from dbSNP and Humsavar for CNKSR1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1889736 -- 26,180,095(+) tgtgt(C/G)tcaag intron-variant, upstream-variant-2KB
rs1889737 -- 26,180,262(+) CTTTT(A/G)AGAAC intron-variant, upstream-variant-2KB
rs1889738 -- 26,180,299(+) AACTC(A/G)GTGGC intron-variant, upstream-variant-2KB
rs2154368 -- 26,175,975(-) CTTAC(A/G)TATTG upstream-variant-2KB, intron-variant
rs2186232 -- 26,176,185(-) gtatc(A/T)ctcaa upstream-variant-2KB, intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CNKSR1 Gene

Variant ID Type Subtype PubMed ID
nsv871237 CNV Loss 21882294

Relevant External Links for CNKSR1 Gene

HapMap Linkage Disequilibrium report
CNKSR1
Human Gene Mutation Database (HGMD)
CNKSR1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CNKSR1 Gene

Disorders for CNKSR1 Gene

No disorders were found for CNKSR1 Gene.

No data available for UniProtKB/Swiss-Prot for CNKSR1 Gene

Publications for CNKSR1 Gene

  1. CNK, a RAF-binding multidomain protein required for RAS signaling. (PMID: 9814705) Therrien M. … Rubin G.M. (Cell 1998) 2 3 4 23
  2. Human CNK1 acts as a scaffold protein, linking Rho and Ras signal transduction pathways. (PMID: 14749388) Jaffe A.B. … Hall A. (Mol. Cell. Biol. 2004) 3 4 23
  3. Bioluminescence resonance energy transfer identify scaffold protein CNK1 interactions in intact cells. (PMID: 15670823) Lopez-Ilasaca M.A. … Xavier R.J. (FEBS Lett. 2005) 3 23
  4. Association of CNK1 with Rho guanine nucleotide exchange factors controls signaling specificity downstream of Rho. (PMID: 15753034) Jaffe A.B. … Schmidt A. (Curr. Biol. 2005) 3 23
  5. KSR and CNK: two scaffolds regulating RAS-mediated RAF activation. (PMID: 17496912) ClapAcron A. … Therrien M. (Oncogene 2007) 3 23

Products for CNKSR1 Gene

Sources for CNKSR1 Gene

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