Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



CNKSR1 Gene

protein-coding   GIFtS: 55
GCID: GC01P026503

Connector Enhancer Of Kinase Suppressor Of Ras 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Connector Enhancer Of Kinase Suppressor Of Ras 11 2     hCNK12 3
Connector Enhancer Of KSR 12 3     CNK2
CNK12 3     KSR2
CNK Homolog Protein 12 3     Connector Enhancer Of KSR-Like3

External Ids:    HGNC: 197001   Entrez Gene: 102562   Ensembl: ENSG000001426757   OMIM: 6032725   UniProtKB: Q969H43   

Export aliases for CNKSR1 gene to outside databases

Previous GC identifers: GC01P026109 GC01P026188 GC01P026376 GC01P024758


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for CNKSR1 Gene:
This gene is a necessary element in receptor tyrosine kinase pathways, possibly as a tyrosine phosphorylation
target. It is involved in regulation of RAF in the MAPK pathway and may also play a role in a MAPK-independent
pathway. (provided by RefSeq, Jul 2008)

GeneCards Summary for CNKSR1 Gene:
CNKSR1 (connector enhancer of kinase suppressor of Ras 1) is a protein-coding gene. Diseases associated with CNKSR1 include endometriosis, and tuberculosis. GO annotations related to this gene include phospholipid binding and protein binding, bridging. An important paralog of this gene is IPCEF1.

UniProtKB/Swiss-Prot: CNKR1_HUMAN, Q969H4
Function: May function as an adapter protein or regulator of Ras signaling pathways

Gene Wiki entry for CNKSR1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000001.11  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CNKSR1 gene promoter:
         HEN1   AP-1   ATF-2   c-Jun   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCNKSR1 promoter sequence
   Search Chromatin IP Primers for CNKSR1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CNKSR1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.11   Ensembl cytogenetic band:  1p36.11   HGNC cytogenetic band: 1p35.3

CNKSR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CNKSR1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P026503:  view genomic region     (about GC identifiers)

Start:
26,503,894 bp from pter      End:
26,516,377 bp from pter
Size:
12,484 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: CNKR1_HUMAN, Q969H4 (See protein sequence)
Recommended Name: Connector enhancer of kinase suppressor of ras 1  
Size: 720 amino acids; 79706 Da
Subunit: Interacts with RHO and RALGDS
1 PDB 3D structure from and Proteopedia for CNKSR1:
1WWV (3D)    
Secondary accessions: B1AMW9 O95381
Alternative splicing: 2 isoforms:  Q969H4-1   Q969H4-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CNKSR1: NX_Q969H4

Explore proteomics data for CNKSR1 at MOPED

Post-translational modifications: 

  • Phosphorylated on tyrosine1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CNKSR1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006305.2  
    ENSEMBL proteins: 
     ENSP00000354609   ENSP00000432057   ENSP00000363371   ENSP00000437038   ENSP00000435880  
     ENSP00000431817   ENSP00000434047  

    CNKSR1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for CNKSR1
    GenScript Custom Purified and Recombinant Proteins Services for CNKSR1
    Novus Biologicals CNKSR1 Proteins
    Novus Biologicals CNKSR1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CNKSR1

    CNKSR1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for CNKSR1
    OriGene Custom Antibody Services for CNKSR1
    Novus Biologicals CNKSR1 Antibodies
    Abcam antibodies for CNKSR1
    Cloud-Clone Corp. Antibodies for CNKSR1
    Search ThermoFisher Antibodies for CNKSR1
    LSBio Antibodies in human, mouse, rat for CNKSR1

    CNKSR1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CNKSR1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CNKSR1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CNKSR1
    Cloud-Clone Corp. CLIAs for CNKSR1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    PLEKH: Pleckstrin homology (PH) domain containing
    SAMD: Sterile alpha motif (SAM) domain containing

    Selected InterPro protein domains (see all 8):
     IPR021129 SAM_type1
     IPR001849 Pleckstrin_homology
     IPR011993 PH_like_dom
     IPR013761 SAM/pointed
     IPR001660 SAM

    Graphical View of Domain Structure for InterPro Entry Q969H4

    ProtoNet protein and cluster: Q969H4

    3 Blocks protein domains:
    IPB001660 Sterile alpha motif SAM
    IPB001849 Pleckstrin-like
    IPB011510 Sterile alpha motif homology 2


    UniProtKB/Swiss-Prot: CNKR1_HUMAN, Q969H4
    Similarity: Belongs to the CNKSR family
    Similarity: Contains 1 CRIC domain
    Similarity: Contains 1 PDZ (DHR) domain
    Similarity: Contains 1 PH domain
    Similarity: Contains 1 SAM (sterile alpha motif) domain


    CNKSR1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CNKR1_HUMAN, Q969H4
    Function: May function as an adapter protein or regulator of Ras signaling pathways

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0016301kinase activity ----
    GO:0030674protein binding, bridging IDA14749388
         
    CNKSR1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CNKSR1:
     Synthetic lethal with c-Myc af 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CNKSR1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CNKSR1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CNKSR1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CNKSR1

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat CNKSR1 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate CNKSR1
    SwitchGear 3'UTR luciferase reporter plasmidCNKSR1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CNKSR1
    Predesigned siRNA for gene silencing in human, mouse, rat CNKSR1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CNKSR1

    Clone
    Products:
         
    OriGene clones in human, mouse for CNKSR1 (see all 8)
    OriGene ORF clones in mouse, rat for CNKSR1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CNKSR1 (NM_006314)
    Sino Biological Human cDNA Clone for CNKSR1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CNKSR1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CNKSR1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CNKSR1
    Browse ESI BIO Cell Lines and PureStem Progenitors for CNKSR1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CNKSR1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    CNKR1_HUMAN, Q969H4: Cytoplasm (By similarity). Membrane; Peripheral membrane protein (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    cytosol3
    nucleus3

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS9814705
    GO:0005911cell-cell junction TAS9814705
    GO:0005938cell cortex IDA15075335

    CNKSR1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for CNKSR1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1NOD-like Receptor Signaling Pathways
    Pathogen or Damage-activated C-Type Lectin Receptor Signaling Pathways0.31

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for CNKSR1
        Pathogen or Damage-activated C-Type Lectin Receptor Signaling Pathways

    3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CNKSR1
        MAPK Signaling
    Ceramide Pathway
    ERK Signaling



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CNKSR1
    Interactions:

        GeneGlobe Interaction Network for CNKSR1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CNKSR1 (Q969H42, 3 ENSP000003546094) via UniProtKB, MINT, STRING, and/or I2D (see all 43)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RHOAP615862, 3, ENSP000004001754MINT-56522 MINT-56518 MINT-56516 MINT-56519 I2D: score=5 STRING: ENSP00000400175
    CYTH3O437392, 3, ENSP000002970444MINT-66188 I2D: score=5 STRING: ENSP00000297044
    SMAD4Q134852, 3MINT-61978 I2D: score=3 
    RAF1P040492, 3, ENSP000002518494MINT-56513 I2D: score=4 STRING: ENSP00000251849
    RASSF1Q9NS232, 3, ENSP000003495474MINT-56515 I2D: score=4 STRING: ENSP00000349547
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007169transmembrane receptor protein tyrosine kinase signaling pathway TAS9814705
    GO:0007265Ras protein signal transduction IPI14749388
    GO:0007266Rho protein signal transduction IPI14749388

    CNKSR1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CNKSR1 (CNKR1)

    3 Novoseek inferred chemical compound relationships for CNKSR1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ceramide 63.7 4 9531568 (1), 9804808 (1), 12676512 (1)
    threonine 24.3 1 11134016 (1)
    tyrosine 21.1 1 8521512 (1)



    CNKSR1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for CNKSR1 gene: 
    NM_006314.2  

    Unigene Cluster for CNKSR1:

    Connector enhancer of kinase suppressor of Ras 1
    Hs.16232  [show with all ESTs]
    Unigene Representative Sequence: BC012797
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000361530(uc010oex.1 uc001blm.4 uc009vsd.3 uc009vse.3)
    ENST00000481077 ENST00000480348 ENST00000465415 ENST00000374253(uc001bln.4)
    ENST00000525687 ENST00000482227 ENST00000531191 ENST00000524529 ENST00000531150
    ENST00000528001 ENST00000528281 ENST00000480617 ENST00000484874
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CNKSR1 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate CNKSR1
    SwitchGear 3'UTR luciferase reporter plasmidCNKSR1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CNKSR1
    Predesigned siRNA for gene silencing in human, mouse, rat CNKSR1
    Clone
    Products:
         
    OriGene clones in human, mouse for CNKSR1 (see all 8)
    OriGene ORF clones in mouse, rat for CNKSR1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CNKSR1 (NM_006314)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CNKSR1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CNKSR1
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for CNKSR1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CNKSR1
      QuantiTect SYBR Green Assays in human, mouse, rat CNKSR1
      QuantiFast Probe-based Assays in human, mouse, rat CNKSR1

    Additional mRNA sequence: 

    AB209335.1 AF100153.1 AK001900.1 AK222817.1 AK222904.1 AK292646.1 AK296814.1 AK302056.1 
    BC011604.2 BC012797.2 BT006900.1 NR_023345.1 

    10 DOTS entries:

    DT.412818  DT.95269681  DT.95069868  DT.100806032  DT.100721147  DT.100778809  DT.121348186  DT.100683003 
    DT.121348185  DT.99975514 

    Selected AceView cDNA sequences (see all 99):

    CR624234 BM750903 BU944084 BC012797 CB988737 AI609339 BE140561 BM271803 
    CK824807 AW299295 BQ024435 R48382 BM918431 CA433801 BE730887 BT006900 
    BG479915 BC011604 AW961213 T24751 BI916418 AF100153 BX280341 CB854293 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CNKSR1 (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17a ·
    SP1:                          -                 -     -                                         -                                         -                     
    SP2:                          -                 -     -                                                                                   -                     
    SP3:                          -                 -     -                                         -                                         -                     
    SP4:                                                                                            -           -                             -                     
    SP5:                    -     -                 -     -                                                                                                         

    ExUns: 17b ^ 18 ^ 19 ^ 20 ^ 21
    SP1:                              
    SP2:                              
    SP3:                              
    SP4:                              
    SP5:                              


    ECgene alternative splicing isoforms for CNKSR1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    CNKSR1 expression in normal human tissues (normalized intensities)      CNKSR1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGGGCTACTT
    CNKSR1 Expression
    About this image


    CNKSR1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Neurons
             nGnG Amacrine Cells Inner Nuclear Layer
     
     Kidney (Urinary System)
             Ureteric Bud
     
     Eye (Sensory Organs)
             nGnG Amacrine Cells Inner Nuclear Layer
    CNKSR1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CNKSR1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.16232
        Custom PCR Arrays for CNKSR1
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for CNKSR1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CNKSR1
    QuantiTect SYBR Green Assays in human, mouse, rat CNKSR1
    QuantiFast Probe-based Assays in human, mouse, rat CNKSR1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CNKSR1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for CNKSR1 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cnksr11 , 5 connector enhancer of kinase suppressor of Ras 11, 5 81.22(n)1
    78.6(a)1
      4 (66.50 cM)5
    1942311  NM_001081047.11  NP_001074516.11 
     1342280415 
    chicken
    (Gallus gallus)
    Aves CNKSR11 connector enhancer of kinase suppressor of Ras 1 62.8(n)
    53.78(a)
      419548  XM_004947675.1  XP_004947732.1 
    lizard
    (Anolis carolinensis)
    Reptilia CNKSR16
    connector enhancer of kinase suppressor of Ras 1
    45(a)
    1 ↔ 1
    GL343480.1(390850-426185)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia cnksr11 connector enhancer of kinase suppressor of Ras 1 53.84(n)
    47.1(a)
      100144653  NM_001123424.1  NP_001116896.1 
    zebrafish
    (Danio rerio)
    Actinopterygii cnksr11 connector enhancer of kinase suppressor of Ras 1 54.71(n)
    44.14(a)
      402957  NM_205659.1  NP_991222.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta cnk6
    connector enhancer of ksr
    11(a)
    1 → many
    2R(13301476-13307104)
    worm
    (Caenorhabditis elegans)
    Secernentea cnk-16
    Protein CNK-1 (cnk-1) mRNA, complete cds
    16(a)
    1 → many
    III(10271257-10278579) WBGene00000564


    ENSEMBL Gene Tree for CNKSR1 (if available)
    TreeFam Gene Tree for CNKSR1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for CNKSR1 gene
    IPCEF12  CNKSR32  CNKSR22  
    1 SIMAP similar gene for CNKSR1 using alignment to 7 protein entries:     CNKR1_HUMAN (see all proteins):
    CNKSR3

    CNKSR1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for CNKSR1 (see all 421)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1998739671,2
    C--26502149(+) CCTGTC/TTNNNN 2 -- us2k10--------
    rs343121861,2
    C--26502158(+) TTTTTT/-TTTTT 2 -- us2k11Minor allele frequency- -:0.00NA 2
    rs1908188791,2
    --26502229(+) CTGCAA/CGCTCT 2 -- us2k10--------
    rs1446273721,2
    --26502294(+) CAGGCA/GCCCGC 2 -- us2k10--------
    rs749673111,2
    C,F--26502404(+) CGATTA/TTAGGC 2 -- us2k11Minor allele frequency- T:0.04WA 118
    rs1815585371,2
    --26502414(+) CGTGAA/GCCACC 2 -- us2k10--------
    rs21543681,2
    C,F,O,H--26502466(-) CTTACA/GTATTG 2 -- us2k110Minor allele frequency- G:0.37EA NA NS 756
    rs796165631,2
    F--26502567(+) CTTTCG/AGCCAG 2 -- us2k11Minor allele frequency- A:0.06WA 118
    rs1478643321,2
    C--26502592(+) GTAAAC/TACATA 2 -- us2k10--------
    rs1140344641,2
    F--26502655(+) GGGTGG/ACTTTG 2 -- us2k11Minor allele frequency- A:0.03WA 118

    HapMap Linkage Disequilibrium report for CNKSR1 (26503894 - 26516377 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for CNKSR1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv871237CNV Loss21882294

    Human Gene Mutation Database (HGMD): CNKSR1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CNKSR1
    DNA2.0 Custom Variant and Variant Library Synthesis for CNKSR1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 603272    OMIM disorders: --

    3 diseases for CNKSR1:    About MalaCards
    endometriosis    tuberculosis    hiv-1


    CNKSR1 for disorders           About GeneDecksing


    Export disorders for CNKSR1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for CNKSR1 gene, integrated from 10 sources (see all 42):
    (articles sorted by number of sources associating them with CNKSR1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. CNK, a RAF-binding multidomain protein required for RAS signaling. (PubMed id 9814705)1, 2, 3, 9 Therrien M.... Rubin G.M. (Cell 1998)
    2. Human CNK1 acts as a scaffold protein, linking Rho and Ras signal transduction pathways. (PubMed id 14749388)1, 2, 9 Jaffe A.B.... Hall A. (Mol. Cell. Biol. 2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Association of CNK1 with Rho guanine nucleotide exchange factors controls signaling specificity downstream of Rho. (PubMed id 15753034)1, 9 Jaffe A.B....Schmidt A. (Curr. Biol. 2005)
    5. Bioluminescence resonance energy transfer identify scaffold protein CNK1 interactions in intact cells. (PubMed id 15670823)1, 9 Lopez-Ilasaca M.A....Xavier R.J. (FEBS Lett. 2005)
    6. Carbohydrate-specific signaling through the DC-SIGN signalosome tailors immunity to Mycobacterium tuberculosis, HIV-1 and Helicobacter pylori. (PubMed id 19718030)1, 9 Gringhuis S.I....Geijtenbeek T.B. (Nat. Immunol. 2009)
    7. CNK1 and other scaffolds for Akt/FoxO signaling. (PubMed id 21320536)1 Fritz R.D. and Radziwill G. (Biochim. Biophys. Acta 2011)
    8. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (Sci. Signal. 2011)
    9. CNK1 promotes invasion of cancer cells through NF-kappaB-dependent signaling. (PubMed id 20197385)1 Fritz R.D. and Radziwill G. (Mol. Cancer Res. 2010)
    10. CNK1 is a novel Akt interaction partner that promotes cell proliferation through the Akt-FoxO signalling axis. (PubMed id 20383191)1 Fritz R.D....Radziwill G. (Oncogene 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 10256 HGNC: 19700 AceView: CNKSR1 Ensembl:ENSG00000142675 euGenes: HUgn10256
    ECgene: CNKSR1 H-InvDB: CNKSR1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for CNKSR1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for CNKSR1 gene:
    Search GeneIP for patents involving CNKSR1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for CNKSR1   OriGene RNAi products in human, mouse, rat for CNKSR1  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for CNKSR1  
     OriGene qSTAR qPCR primer pairs in human, mouse for CNKSR1   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for CNKSR1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CNKSR1   OriGene Custom Protein Services for CNKSR1  

     
     
     Block miRNA regulation of human, mouse, rat CNKSR1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing CNKSR1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CNKSR1 Predesigned siRNA for gene silencing in human, mouse, rat CNKSR1
     QuantiFast Probe-based Assays in human, mouse, rat CNKSR1 QuantiTect SYBR Green Assays in human, mouse, rat CNKSR1
     Custom PCR Arrays for CNKSR1 Search Chromatin IP Primers for CNKSR1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CNKSR1  GeneGlobe Interaction Network for CNKSR1
     Regulatory tfbs in CNKSR1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for CNKSR1 GenScript cDNA clones with any tag delivered in your preferred vector for CNKSR1
     GenScript Custom Assay Services for CNKSR1 GenScript Custom overexpressing Cell Line Services for CNKSR1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for CNKSR1 (CNKR1)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for CNKSR1
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     CNKSR1 antibodies
     CNKSR1 proteins
     CNKSR1 lysates
     Antibodies for CNKSR1
     See all of Abcam's Antibodies, Kits and Proteins for CNKSR1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for CNKSR1
     Antibodies for CNKSR1
     ELISAs for CNKSR1
     CLIAs for CNKSR1



     Browse ESI BIO Cell Lines and PureStem Progenitors for CNKSR1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CNKSR1
     SwitchGear 3'UTR luciferase reporter plasmids for CNKSR1
     SwitchGear Promoter luciferase reporter plasmids for CNKSR1
     Search ThermoFisher Antibodies for CNKSR1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CNKSR1
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CNKSR1
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CNKSR1
     LSBio Antibodies in human, mouse, rat for CNKSR1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      CNKSR1 gene at Home site.
    Version: 3.12.136 22 July 2014
    hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4