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Aliases for CNIH4 Gene

Aliases for CNIH4 Gene

  • Cornichon Family AMPA Receptor Auxiliary Protein 4 2 3 4 5
  • CNIH-4 3 4
  • Cornichon Homolog 4 (Drosophila) 2
  • Cornichon Homolog 4 3
  • HSPC163 3

External Ids for CNIH4 Gene

Previous GeneCards Identifiers for CNIH4 Gene

  • GC01P220852
  • GC01P222611
  • GC01P224545
  • GC01P195064

Summaries for CNIH4 Gene

GeneCards Summary for CNIH4 Gene

CNIH4 (Cornichon Family AMPA Receptor Auxiliary Protein 4) is a Protein Coding gene. GO annotations related to this gene include CCR5 chemokine receptor binding. An important paralog of this gene is CNIH2.

UniProtKB/Swiss-Prot for CNIH4 Gene

  • Involved in G protein-coupled receptors (GPCRs) trafficking from the endoplasmic reticulum to the cell surface; it promotes the exit of GPCRs from the early secretory pathway, likely through interaction with the COPII machinery (PubMed:24405750).

Gene Wiki entry for CNIH4 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CNIH4 Gene

Genomics for CNIH4 Gene

Regulatory Elements for CNIH4 Gene

Enhancers for CNIH4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CNIH4 on UCSC Golden Path with GeneCards custom track

Promoters for CNIH4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CNIH4 on UCSC Golden Path with GeneCards custom track

Genomic Location for CNIH4 Gene

224,356,811 bp from pter
224,379,459 bp from pter
22,649 bases
Plus strand

Genomic View for CNIH4 Gene

Genes around CNIH4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CNIH4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CNIH4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CNIH4 Gene

Proteins for CNIH4 Gene

  • Protein details for CNIH4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein cornichon homolog 4
    Protein Accession:
    Secondary Accessions:
    • A8K1Q8
    • B2R553
    • Q9H0X8

    Protein attributes for CNIH4 Gene

    139 amino acids
    Molecular mass:
    16093 Da
    Quaternary structure:
    • Interacts with Sec23/24 complex components SEC24B and SEC24D (PubMed:24405750). Interacts with CCR5 (PubMed:24405750). Interacts with ADRB2 in the early secretory pathway (PubMed:24405750).

    Alternative splice isoforms for CNIH4 Gene


neXtProt entry for CNIH4 Gene

Proteomics data for CNIH4 Gene at MOPED

Post-translational modifications for CNIH4 Gene

No Post-translational modifications

Other Protein References for CNIH4 Gene

No data available for DME Specific Peptides for CNIH4 Gene

Domains & Families for CNIH4 Gene

Protein Domains for CNIH4 Gene


Suggested Antigen Peptide Sequences for CNIH4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the cornichon family.
  • Belongs to the cornichon family.
genes like me logo Genes that share domains with CNIH4: view

No data available for Gene Families for CNIH4 Gene

Function for CNIH4 Gene

Molecular function for CNIH4 Gene

UniProtKB/Swiss-Prot Function:
Involved in G protein-coupled receptors (GPCRs) trafficking from the endoplasmic reticulum to the cell surface; it promotes the exit of GPCRs from the early secretory pathway, likely through interaction with the COPII machinery (PubMed:24405750).

Animal Model Products

  • Taconic Biosciences Mouse Models for CNIH4

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CNIH4 Gene

Localization for CNIH4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CNIH4 Gene

Membrane; Multi-pass membrane protein. Endoplasmic reticulum. Endoplasmic reticulum-Golgi intermediate compartment.

Subcellular locations from

Jensen Localization Image for CNIH4 Gene COMPARTMENTS Subcellular localization image for CNIH4 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 3

Gene Ontology (GO) - Cellular Components for CNIH4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment IDA 24405750
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CNIH4: view

Pathways & Interactions for CNIH4 Gene

SuperPathways for CNIH4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CNIH4 Gene


No data available for Pathways by source and SIGNOR curated interactions for CNIH4 Gene

Drugs & Compounds for CNIH4 Gene

No Compound Related Data Available

Transcripts for CNIH4 Gene

Unigene Clusters for CNIH4 Gene

Cornichon homolog 4 (Drosophila):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CNIH4 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b · 6c
SP1: - -
SP2: - - -
SP3: - - - -
SP4: -

Relevant External Links for CNIH4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CNIH4 Gene

mRNA expression in normal human tissues for CNIH4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CNIH4 Gene

This gene is overexpressed in Nasal epithelium (12.6), Monocytes (11.0), and Placenta (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CNIH4 Gene

SOURCE GeneReport for Unigene cluster for CNIH4 Gene Hs.445890

genes like me logo Genes that share expression patterns with CNIH4: view

Protein tissue co-expression partners for CNIH4 Gene

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CNIH4 Gene

Orthologs for CNIH4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CNIH4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CNIH4 35
  • 93.76 (n)
  • 96.4 (a)
CNIH4 36
  • 96 (a)
(Canis familiaris)
Mammalia CNIH4 35
  • 89.66 (n)
  • 94.83 (a)
CNIH4 36
  • 95 (a)
(Mus musculus)
Mammalia Cnih4 35
  • 89.93 (n)
  • 95.68 (a)
Cnih4 16
Cnih4 36
  • 96 (a)
(Pan troglodytes)
Mammalia CNIH4 35
  • 99.52 (n)
  • 98.56 (a)
CNIH4 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Cnih4 35
  • 89.45 (n)
  • 93.53 (a)
(Monodelphis domestica)
Mammalia CNIH4 36
  • 96 (a)
(Ornithorhynchus anatinus)
Mammalia CNIH4 36
  • 81 (a)
(Gallus gallus)
Aves CNIH4 35
  • 82.25 (n)
  • 92.09 (a)
(Anolis carolinensis)
Reptilia CNIH4 36
  • 96 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cnih4 35
  • 78.9 (n)
  • 89.21 (a)
MGC76215 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.16228 35
(Danio rerio)
Actinopterygii cnih4 35
  • 74.19 (n)
  • 80.65 (a)
cnih4 36
  • 76 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1830 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009116 35
  • 58.15 (n)
  • 51.82 (a)
fruit fly
(Drosophila melanogaster)
Insecta cnir 35
  • 52.8 (n)
  • 45.26 (a)
cnir 36
  • 39 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C05478g 35
  • 54.33 (n)
  • 41.73 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ERV14 35
  • 52.63 (n)
  • 44.36 (a)
ERV14 36
  • 43 (a)
ERV15 36
  • 33 (a)
ERV15 38
bread mold
(Neurospora crassa)
Ascomycetes NCU06922 35
  • 51.77 (n)
  • 46.97 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5341 36
  • 50 (a)
Species with no ortholog for CNIH4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CNIH4 Gene

Gene Tree for CNIH4 (if available)
Gene Tree for CNIH4 (if available)

Paralogs for CNIH4 Gene

Paralogs for CNIH4 Gene

(3) SIMAP similar genes for CNIH4 Gene using alignment to 3 proteins: Pseudogenes for CNIH4 Gene

genes like me logo Genes that share paralogs with CNIH4: view

Variants for CNIH4 Gene

Sequence variations from dbSNP and Humsavar for CNIH4 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs12123896 - 224,356,932(+) GGAGG(C/G/T)GGTGG nc-transcript-variant, upstream-variant-2KB, reference, missense, utr-variant-5-prime
rs12361 -- 224,376,675(-) GGCAC(A/C)ACGTG intron-variant, nc-transcript-variant, utr-variant-3-prime
rs1857042 -- 224,360,672(-) AATAA(A/G)AGACA intron-variant
rs3841826 -- 224,377,351(-) GGGAC(-/T)TGTTT intron-variant, downstream-variant-500B
rs2897051 -- 224,373,436(-) TACTC(A/C/G/T)GCAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CNIH4 Gene

Variant ID Type Subtype PubMed ID
nsv8868 CNV Loss 18304495
nsv469889 CNV Complex 16826518

Variation tolerance for CNIH4 Gene

Residual Variation Intolerance Score: 82.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.61; 13.15% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for CNIH4 Gene

Disorders for CNIH4 Gene

Relevant External Links for CNIH4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CNIH4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CNIH4 Gene

Publications for CNIH4 Gene

  1. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 2 3 4 67
  2. ABCE1 is a highly conserved RNA silencing suppressor. (PMID: 25659154) KAorblane K. … Sarmiento C. (PLoS ONE 2015) 3
  3. Control of a neuronal morphology program by an RNA-binding zinc finger protein, Unkempt. (PMID: 25737280) Murn J. … Shi Y. (Genes Dev. 2015) 3
  4. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta G.D. … Pelletier L. (Cell 2015) 3
  5. CNIH4 interacts with newly synthesized GPCR and controls their export from the endoplasmic reticulum. (PMID: 24405750) Sauvageau E. … Bouvier M. (Traffic 2014) 3

Products for CNIH4 Gene

Sources for CNIH4 Gene