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Aliases for CNIH4 Gene

Aliases for CNIH4 Gene

  • Cornichon Family AMPA Receptor Auxiliary Protein 4 2 3 4
  • CNIH-4 3 4
  • Cornichon Homolog 4 (Drosophila) 2
  • Protein Cornichon Homolog 4 3
  • Cornichon Homolog 4 3
  • HSPC163 3

External Ids for CNIH4 Gene

Previous GeneCards Identifiers for CNIH4 Gene

  • GC01P220852
  • GC01P222611
  • GC01P224545
  • GC01P195064

Summaries for CNIH4 Gene

GeneCards Summary for CNIH4 Gene

CNIH4 (Cornichon Family AMPA Receptor Auxiliary Protein 4) is a Protein Coding gene. An important paralog of this gene is CNIH2.

UniProtKB/Swiss-Prot for CNIH4 Gene

  • Involved in G protein-coupled receptors (GPCRs) trafficking from the endoplasmic reticulum to the cell surface; it promotes the exit of GPCRs from the early secretory pathway, likely through interaction with the COPII machinery (PubMed:24405750).

Gene Wiki entry for CNIH4 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CNIH4 Gene

Genomics for CNIH4 Gene

Regulatory Elements for CNIH4 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CNIH4 Gene

Start:
224,356,811 bp from pter
End:
224,379,459 bp from pter
Size:
22,649 bases
Orientation:
Plus strand

Genomic View for CNIH4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CNIH4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CNIH4 Gene

Proteins for CNIH4 Gene

  • Protein details for CNIH4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P003-CNIH4_HUMAN
    Recommended name:
    Protein cornichon homolog 4
    Protein Accession:
    Q9P003
    Secondary Accessions:
    • A8K1Q8
    • B2R553
    • Q9H0X8

    Protein attributes for CNIH4 Gene

    Size:
    139 amino acids
    Molecular mass:
    16093 Da
    Quaternary structure:
    • Interacts with Sec23/24 complex components SEC24B and SEC24D (PubMed:24405750). Interacts with CCR5 (PubMed:24405750). Interacts with ADRB2 in the early secretory pathway (PubMed:24405750).

    Alternative splice isoforms for CNIH4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CNIH4 Gene

Proteomics data for CNIH4 Gene at MOPED

Post-translational modifications for CNIH4 Gene

No Post-translational modifications

Other Protein References for CNIH4 Gene

No data available for DME Specific Peptides for CNIH4 Gene

Domains for CNIH4 Gene

Protein Domains for CNIH4 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for CNIH4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9P003

UniProtKB/Swiss-Prot:

CNIH4_HUMAN :
  • Q9P003
Family:
  • Belongs to the cornichon family.
genes like me logo Genes that share domains with CNIH4: view

No data available for Gene Families for CNIH4 Gene

Function for CNIH4 Gene

Molecular function for CNIH4 Gene

UniProtKB/Swiss-Prot Function: Involved in G protein-coupled receptors (GPCRs) trafficking from the endoplasmic reticulum to the cell surface; it promotes the exit of GPCRs from the early secretory pathway, likely through interaction with the COPII machinery (PubMed:24405750).

Gene Ontology (GO) - Molecular Function for CNIH4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 24405750
GO:0031730 CCR5 chemokine receptor binding IPI 24405750
genes like me logo Genes that share ontologies with CNIH4: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for CNIH4 Gene

Localization for CNIH4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CNIH4 Gene

Membrane; Multi-pass membrane protein. Endoplasmic reticulum. Endoplasmic reticulum-Golgi intermediate compartment.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CNIH4 Gene COMPARTMENTS Subcellular localization image for CNIH4 gene
Compartment Confidence
endoplasmic reticulum 4
plasma membrane 3
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CNIH4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IDA --
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment IDA 24405750
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CNIH4: view

Pathways for CNIH4 Gene

SuperPathways for CNIH4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CNIH4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006888 ER to Golgi vesicle-mediated transport IMP 24405750
GO:0035556 intracellular signal transduction IEA --
genes like me logo Genes that share ontologies with CNIH4: view

No data available for Pathways by source for CNIH4 Gene

Transcripts for CNIH4 Gene

Unigene Clusters for CNIH4 Gene

Cornichon homolog 4 (Drosophila):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CNIH4

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for CNIH4

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CNIH4 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b · 6c
SP1: - -
SP2: - - -
SP3: - - - -
SP4: -
SP5:

Relevant External Links for CNIH4 Gene

GeneLoc Exon Structure for
CNIH4
ECgene alternative splicing isoforms for
CNIH4

Expression for CNIH4 Gene

mRNA expression in normal human tissues for CNIH4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CNIH4 Gene

SOURCE GeneReport for Unigene cluster for CNIH4 Gene Hs.445890

genes like me logo Genes that share expressions with CNIH4: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CNIH4 Gene

Orthologs for CNIH4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CNIH4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CNIH4 35
  • 99.52 (n)
  • 98.56 (a)
CNIH4 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CNIH4 35
  • 93.76 (n)
  • 96.4 (a)
CNIH4 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CNIH4 35
  • 89.66 (n)
  • 94.83 (a)
CNIH4 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cnih4 35
  • 89.93 (n)
  • 95.68 (a)
Cnih4 16
Cnih4 36
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CNIH4 36
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CNIH4 36
  • 81 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cnih4 35
  • 89.45 (n)
  • 93.53 (a)
chicken
(Gallus gallus)
Aves CNIH4 35
  • 82.25 (n)
  • 92.09 (a)
lizard
(Anolis carolinensis)
Reptilia CNIH4 36
  • 96 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.16228 35
tropical clawed frog
(Silurana tropicalis)
Amphibia cnih4 35
  • 78.9 (n)
  • 89.21 (a)
MGC76215 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1830 35
zebrafish
(Danio rerio)
Actinopterygii cnih4 35
  • 74.19 (n)
  • 80.65 (a)
cnih4 36
  • 76 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009116 35
  • 58.15 (n)
  • 51.82 (a)
fruit fly
(Drosophila melanogaster)
Insecta cnir 35
  • 52.8 (n)
  • 45.26 (a)
cnir 36
  • 39 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ERV14 35
  • 52.63 (n)
  • 44.36 (a)
ERV14 36
  • 43 (a)
ManyToMany
ERV15 36
  • 33 (a)
ManyToMany
ERV15 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C05478g 35
  • 54.33 (n)
  • 41.73 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU06922 35
  • 51.77 (n)
  • 46.97 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5341 36
  • 50 (a)
OneToOne
Species with no ortholog for CNIH4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CNIH4 Gene

ENSEMBL:
Gene Tree for CNIH4 (if available)
TreeFam:
Gene Tree for CNIH4 (if available)

Paralogs for CNIH4 Gene

Paralogs for CNIH4 Gene

Selected SIMAP similar genes for CNIH4 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for CNIH4 Gene

genes like me logo Genes that share paralogs with CNIH4: view

Variants for CNIH4 Gene

Sequence variations from dbSNP and Humsavar for CNIH4 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs6671751 -- 224,358,082(+) TCATT(C/T)TTCAT intron-variant
rs7517754 -- 224,356,827(+) CGAGG(A/G)CCACA utr-variant-5-prime, nc-transcript-variant, upstream-variant-2KB
rs10799568 -- 224,355,391(+) aaaac(A/G)tgtgc upstream-variant-2KB
rs10916599 -- 224,355,037(+) cggca(C/G)agcac upstream-variant-2KB
rs11554770 -- 224,356,912(+) GGCGA(A/G)CGGAG utr-variant-5-prime, nc-transcript-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CNIH4 Gene

Variant ID Type Subtype PubMed ID
nsv8868 CNV Loss 18304495
nsv469889 CNV Complex 16826518

Relevant External Links for CNIH4 Gene

HapMap Linkage Disequilibrium report
CNIH4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CNIH4 Gene

Disorders for CNIH4 Gene

No disorders were found for CNIH4 Gene.

No data available for UniProtKB/Swiss-Prot for CNIH4 Gene

Publications for CNIH4 Gene

  1. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 2 3 4
  2. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4
  3. CNIH4 interacts with newly synthesized GPCR and controls their export from the endoplasmic reticulum. (PMID: 24405750) Sauvageau E. … Bouvier M. (Traffic 2014) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. From ORFeome to biology: a functional genomics pipeline. (PMID: 15489336) Wiemann S. … Poustka A. (Genome Res. 2004) 3

Products for CNIH4 Gene

Sources for CNIH4 Gene

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