CNIH4 Gene
protein-coding GIFtS: 45
GCID: GC01P224545
|
|
cornichon homolog 4 (Drosophila)
| |
Aliases
for CNIH4 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Cornichon Homolog 4 (Drosophila)1 2 | | HSPC1631 | | Protein Cornichon Homolog 42 |
Export aliases for CNIH4 gene to outside databasesPrevious GC identifers: GC01P220852 GC01P222611 GC01P195064 |
Summaries
for CNIH4 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Gene Wiki entry for CNIH4
|
Genomic Views
for CNIH4 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_167186.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CNIH4 gene promoter:
LHX3b/Lhx3b Brachyury NCX/Ncx Nkx2-2 HNF-3beta Egr-4 GATA-1 Sox9 LHX3a/Lhx3a MRF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for CNIH4
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CNIH4 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1q42.11 Ensembl cytogenetic band: 1q42.11 HGNC cytogenetic band: 1q42.12CNIH4 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P224545: view genomic region
(about GC identifiers)
Start:
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224,544,552 bp from pter |
End:
|
224,567,161 bp from pter |
Size:
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22,610 bases |
Orientation:
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plus strand |
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Proteins
for CNIH4 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CNIH4_HUMAN, Q9P003 (See
protein sequence)Recommended Name: Protein cornichon homolog 4 Size: 139 amino acids; 16093 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Secondary accessions: A8K1Q8 B2R553 Q9H0X8Alternative splicing: 2 isoforms: Q9P003-1 Q9P003-2 Explore the universe of human proteins at neXtProt for CNIH4: NX_Q9P003
CNIH4 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_054903.1
ENSEMBL proteins: ENSP00000420443 ENSP00000355823 ENSP00000355822 ENSP00000355821
Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
CNIH4 for ontologies About GeneDecksing
CNIH4 Antibody Products:
Assay Products for CNIH4: |
Protein
Domains /
Families
for CNIH4 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CNIH4 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9P003ProtoNet protein and cluster: Q9P003 1 Blocks protein family: IPB003377 Cornichon
UniProtKB/Swiss-Prot: CNIH4_HUMAN, Q9P003Similarity: Belongs to the cornichon family |
Function
for CNIH4 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CNIH4 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CNIH4
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: CNIH4 (NM_014184) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CNIH4 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CNIH4 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CNIH4 |
|
Pathways & Interactions
for CNIH4 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CNIH4
STRING Interaction
Network Preview (showing 5 interactants - click image to see 13)
5/75 Interacting proteins for CNIH4 (Q9P0033 ENSP000004204434) via UniProtKB, MINT, STRING, and/or I2D (see all 75)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0035556 | intracellular signal transduction |
IEA | -- |
CNIH4 for ontologies About GeneDecksing
|
Drugs & Compounds
for CNIH4 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CNIH4
Search CenterWatch for drugs/clinical trials and news about CNIH4
|
Transcripts
for CNIH4 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CNIH4 gene: NM_014184.2 Unigene Cluster for CNIH4: Cornichon homolog 4 (Drosophila) Hs.445890 [show with all ESTs]Unigene Representative Sequence: BX6490768 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000465271(uc001hom.1) ENST00000366858 ENST00000366857(uc001hon.1)
ENST00000366860 ENST00000468318 ENST00000366856 ENST00000477413 ENST00000469200
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CNIH4 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CNIH4
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: CNIH4 (NM_014184) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CNIH4 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CNIH4 |
Additional cDNA sequence: AF161512.1 AK024237.1 AK024569.1 AK222634.1 AK289973.1 AK312064.1 AL136930.1 BC000573.1 BC039037.1 BX649076.1 15 DOTS entries: DT.92442860 DT.210806 DT.400837 DT.121419536 DT.91882179 DT.91749663 DT.100748299 DT.121419534 DT.100748298 DT.100785314 DT.121419563 DT.121613905 DT.92442852 DT.92442861 DT.95350558 24/266 AceView cDNA sequences (see all 266): AW293746 BQ216892 AA053139 AW342036 BU855843 CB306175 AW874395 CA425296 AI419931 BG248347 BC000573 BC039037 BQ227001 AI277337 BI918355 BG109710 BM930964 CR590797 BM768685 W95793 AI097662 BM684463 AA055226 AL136930
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for CNIH4 About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | · | 6c |
|---|
|
| SP1: | | | | | | | | | | | - | | | | | | | | - | | | | | | | | |
| SP2: | | | | | | | | | | | - | | | | - | | | | - | | | | | | | | |
| SP3: | | | | | | | | | | | - | | | | - | | - | | - | | | | | | | | |
| SP4: | | | | | | | | | | | - | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for CNIH4
|
Expression
for CNIH4 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CNIH4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TATCTTTATA
About this image
See CNIH4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CNIH4
SOURCE GeneReport for Unigene cluster: Hs.445890
SABiosciences Custom PCR Arrays for CNIH4
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CNIH4
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CNIH4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CNIH4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CNIH4 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CNIH4 |
Orthologs
for CNIH4 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for CNIH4 gene from 8/32 species (see all 32) About this table
ENSEMBL Gene Tree for CNIH4 (if available)
TreeFam Gene Tree for CNIH4 (if available) |
Paralogs
for CNIH4 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CNIH4 gene
- CNIH2 CNIH32 CNIH22
2 SIMAP similar genes for CNIH4 using alignment to 3 protein entries: CNIH4_HUMAN (see all proteins):CNIH CNIH3
CNIH4 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for CNIH4
PGOHUM00000243354
|
Genomic Variants
for CNIH4 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CNIH4 (224544552 - 224567161 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for CNIH4
1 CNV: 31690 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CNIH4 |
|
Disorders
/ Diseases
for CNIH4 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for CNIH4 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CNIH4 gene, integrated from 9 sources (see all 15):
(articles sorted by number of sources associating them with CNIH4) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2, 3 Zhang Q.-H.... Chen Z. (2000)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (2001)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Genome-wide association study of major depressive dis order: new results, meta-analysis, and lessons learned. (PubMed id 21042317)1 Wray N.R....Sullivan P.F. (2010)
- Large-scale mapping of human protein-protein interactions by mass spectrometry. (PubMed id 17353931)1 Ewing R.M.... Figeys D. (2007)
- The LIFEdb database in 2006. (PubMed id 16381901)1 Mehrle A....Wiemann S. (2006)
- Large-scale analysis of the human ubiquitin-related p roteome. (PubMed id 16196087)1 Matsumoto M....Nakayama K.I. (2005)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
|
External Searches for CNIH4 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CNIH4 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CNIH4 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CNIH4 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CNIH4 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for CNIH4 gene:
Search GeneIP for patents involving CNIH4
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CNIH4 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for CNIH4 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CNIH4 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CNIH4 | | | OriGene Protein Over-expression Lysate for CNIH4 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CNIH4 | | OriGene 3'-UTR Clone for CNIH4 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CNIH4 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CNIH4 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for CNIH4 | | OriGene Custom Protein Services for CNIH4 | | | OriGene Custom Immunoassay Development | | |
| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CNIH4 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CNIH4 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CNIH4 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CNIH4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CNIH4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CNIH4 |
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| | | | Search Tocris compounds for CNIH4 |
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 | | | CNIH4 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CNIH4 |
|  |  |  | | | | Search ThermoFisher Antibodies for CNIH4 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CNIH4 |
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