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Aliases for CNIH4 Gene

Aliases for CNIH4 Gene

  • Cornichon Family AMPA Receptor Auxiliary Protein 4 2 3 4 5
  • CNIH-4 3 4
  • Cornichon Homolog 4 (Drosophila) 2
  • Protein Cornichon Homolog 4 3
  • Cornichon Homolog 4 3
  • HSPC163 3

External Ids for CNIH4 Gene

Previous GeneCards Identifiers for CNIH4 Gene

  • GC01P220852
  • GC01P222611
  • GC01P224545
  • GC01P195064

Summaries for CNIH4 Gene

GeneCards Summary for CNIH4 Gene

CNIH4 (Cornichon Family AMPA Receptor Auxiliary Protein 4) is a Protein Coding gene. GO annotations related to this gene include CCR5 chemokine receptor binding. An important paralog of this gene is CNIH1.

UniProtKB/Swiss-Prot for CNIH4 Gene

  • Involved in G protein-coupled receptors (GPCRs) trafficking from the endoplasmic reticulum to the cell surface; it promotes the exit of GPCRs from the early secretory pathway, likely through interaction with the COPII machinery (PubMed:24405750).

Gene Wiki entry for CNIH4 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CNIH4 Gene

Genomics for CNIH4 Gene

Regulatory Elements for CNIH4 Gene

Enhancers for CNIH4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F224376 1.2 Ensembl ENCODE 48.1 +22.1 22084 5.0 HDGF PKNOX1 TBL1XR1 FEZF1 ZNF2 ZNF121 EGR1 FOS CREM EGR2 CNIH4 NVL CNIH3 WDR26 GC01P224379 MIR4742
GH01F224356 1.5 FANTOM5 ENCODE 37.2 +0.6 597 2.4 PKNOX1 ARNT CREB3L1 ARID4B SIN3A DMAP1 YBX1 ZNF2 YY1 ZNF143 CNIH4 NVL CNIH3 WDR26 LOC101927164 LOC101927143 CAPN2 DEGS1 FBXO28 GC01P224379
GH01F224456 1.1 Ensembl ENCODE 46.5 +101.4 101415 4.1 HDGF ZNF2 RAD21 RFX5 ZNF143 ZNF263 ZNF362 ZNF654 USF2 REST CNIH4 CNIH3 WDR26 NVL DEGS1 GC01M224438 GC01P224480
GH01F224429 1.2 ENCODE 36.3 +76.7 76698 7.2 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 CICP5 CNIH4 RN7SKP49 FBXO28 GTF2IP20 CNIH3 GC01P224430
GH01F224501 1.8 FANTOM5 Ensembl ENCODE 22.7 +146.7 146690 3.8 HDGF PKNOX1 ARNT CREB3L1 SIN3A FEZF1 ZNF2 YY1 SLC30A9 CBX5 CICP5 CNIH4 WDR26 CNIH3 GC01P224480 AKR1B1P1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CNIH4 on UCSC Golden Path with GeneCards custom track

Promoters for CNIH4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001038246 490 1800 PKNOX1 ARNT CREB3L1 ARID4B SIN3A DMAP1 YBX1 ZNF2 YY1 ZNF143

Genomic Location for CNIH4 Gene

Chromosome:
1
Start:
224,356,811 bp from pter
End:
224,379,459 bp from pter
Size:
22,649 bases
Orientation:
Plus strand

Genomic View for CNIH4 Gene

Genes around CNIH4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CNIH4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CNIH4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CNIH4 Gene

Proteins for CNIH4 Gene

  • Protein details for CNIH4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P003-CNIH4_HUMAN
    Recommended name:
    Protein cornichon homolog 4
    Protein Accession:
    Q9P003
    Secondary Accessions:
    • A8K1Q8
    • B2R553
    • Q9H0X8

    Protein attributes for CNIH4 Gene

    Size:
    139 amino acids
    Molecular mass:
    16093 Da
    Quaternary structure:
    • Interacts with Sec23/24 complex components SEC24B and SEC24D (PubMed:24405750). Interacts with CCR5 (PubMed:24405750). Interacts with ADRB2 in the early secretory pathway (PubMed:24405750).

    Alternative splice isoforms for CNIH4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CNIH4 Gene

Post-translational modifications for CNIH4 Gene

No Post-translational modifications

Other Protein References for CNIH4 Gene

No data available for DME Specific Peptides for CNIH4 Gene

Domains & Families for CNIH4 Gene

Protein Domains for CNIH4 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for CNIH4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9P003

UniProtKB/Swiss-Prot:

CNIH4_HUMAN :
  • Belongs to the cornichon family.
Family:
  • Belongs to the cornichon family.
genes like me logo Genes that share domains with CNIH4: view

No data available for Gene Families for CNIH4 Gene

Function for CNIH4 Gene

Molecular function for CNIH4 Gene

UniProtKB/Swiss-Prot Function:
Involved in G protein-coupled receptors (GPCRs) trafficking from the endoplasmic reticulum to the cell surface; it promotes the exit of GPCRs from the early secretory pathway, likely through interaction with the COPII machinery (PubMed:24405750).

Gene Ontology (GO) - Molecular Function for CNIH4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 24405750
GO:0031730 CCR5 chemokine receptor binding IPI 24405750
genes like me logo Genes that share ontologies with CNIH4: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CNIH4

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CNIH4 Gene

Localization for CNIH4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CNIH4 Gene

Membrane; Multi-pass membrane protein. Endoplasmic reticulum. Endoplasmic reticulum-Golgi intermediate compartment.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CNIH4 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 3

Gene Ontology (GO) - Cellular Components for CNIH4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA,IDA 24405750
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment IEA,IDA 24405750
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CNIH4: view

Pathways & Interactions for CNIH4 Gene

SuperPathways for CNIH4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CNIH4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006888 ER to Golgi vesicle-mediated transport IMP 24405750
GO:0015031 protein transport IEA --
GO:0016192 vesicle-mediated transport IEA --
genes like me logo Genes that share ontologies with CNIH4: view

No data available for Pathways by source and SIGNOR curated interactions for CNIH4 Gene

Transcripts for CNIH4 Gene

Unigene Clusters for CNIH4 Gene

Cornichon homolog 4 (Drosophila):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CNIH4 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b · 6c
SP1: - -
SP2: - - -
SP3: - - - -
SP4: -
SP5:

Relevant External Links for CNIH4 Gene

GeneLoc Exon Structure for
CNIH4
ECgene alternative splicing isoforms for
CNIH4

Expression for CNIH4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CNIH4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CNIH4 Gene

This gene is overexpressed in Nasal epithelium (12.6), Monocytes (11.0), and Placenta (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CNIH4 Gene



Protein tissue co-expression partners for CNIH4 Gene

NURSA nuclear receptor signaling pathways regulating expression of CNIH4 Gene:

CNIH4

SOURCE GeneReport for Unigene cluster for CNIH4 Gene:

Hs.445890
genes like me logo Genes that share expression patterns with CNIH4: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CNIH4 Gene

Orthologs for CNIH4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CNIH4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CNIH4 34 35
  • 99.52 (n)
oppossum
(Monodelphis domestica)
Mammalia CNIH4 35
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CNIH4 34 35
  • 93.76 (n)
mouse
(Mus musculus)
Mammalia Cnih4 34 16 35
  • 89.93 (n)
dog
(Canis familiaris)
Mammalia CNIH4 34 35
  • 89.66 (n)
rat
(Rattus norvegicus)
Mammalia Cnih4 34
  • 89.45 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CNIH4 35
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves CNIH4 34
  • 82.25 (n)
lizard
(Anolis carolinensis)
Reptilia CNIH4 35
  • 96 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cnih4 34
  • 78.9 (n)
MGC76215 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.16228 34
zebrafish
(Danio rerio)
Actinopterygii cnih4 34 35
  • 74.19 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1830 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009116 34
  • 58.15 (n)
fruit fly
(Drosophila melanogaster)
Insecta cnir 34 35
  • 52.8 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C05478g 34
  • 54.33 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ERV14 34 35
  • 52.63 (n)
ERV15 35 37
  • 33 (a)
ManyToMany
bread mold
(Neurospora crassa)
Ascomycetes NCU06922 34
  • 51.77 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5341 35
  • 50 (a)
OneToOne
Species where no ortholog for CNIH4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CNIH4 Gene

ENSEMBL:
Gene Tree for CNIH4 (if available)
TreeFam:
Gene Tree for CNIH4 (if available)

Paralogs for CNIH4 Gene

Paralogs for CNIH4 Gene

(3) SIMAP similar genes for CNIH4 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for CNIH4 Gene

genes like me logo Genes that share paralogs with CNIH4: view

Variants for CNIH4 Gene

Sequence variations from dbSNP and Humsavar for CNIH4 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs10495221 -- 224,370,506(-) CCAGA(A/C)TGTGT intron-variant
rs10554288 -- 224,366,740(+) GATCA(-/CT)TGAGG intron-variant
rs10707628 -- 224,366,979(+) AAAAA(-/A)GCTGC intron-variant
rs10799568 -- 224,355,391(+) aaaac(A/G)tgtgc upstream-variant-2KB
rs10799569 -- 224,371,110(+) GACCT(C/G)AGGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CNIH4 Gene

Variant ID Type Subtype PubMed ID
esv2508330 CNV deletion 19546169
nsv1127063 CNV deletion 24896259
nsv469889 CNV gain 16826518
nsv8868 CNV loss 18304495

Variation tolerance for CNIH4 Gene

Residual Variation Intolerance Score: 82.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.61; 13.15% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CNIH4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CNIH4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CNIH4 Gene

Disorders for CNIH4 Gene

Relevant External Links for CNIH4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CNIH4

No disorders were found for CNIH4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CNIH4 Gene

Publications for CNIH4 Gene

  1. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 2 3 4 64
  2. CNIH4 interacts with newly synthesized GPCR and controls their export from the endoplasmic reticulum. (PMID: 24405750) Sauvageau E. … Bouvier M. (Traffic 2014) 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4 64

Products for CNIH4 Gene

Sources for CNIH4 Gene

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