CNIH3 Gene
protein-coding GIFtS : 44
GCID: GC01 P224622
cornichon homolog 3 (Drosophila)
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Aliasesfor CNIH3 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Cornichon Homolog 3 (Drosophila) 1 2 CNIH-31 2 FLJ389931 Protein Cornichon Homolog 32
Export aliases for CNIH3 gene to outside databases Previous GC identifers: GC01P221111 GC01P222870 GC01P195324
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Summariesfor CNIH3 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section UniProtKB/Swiss-Prot: CNIH3_HUMAN, Q8TBE1 Function : Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotestheir targeting to the cell membrane and synapses and modulates their gating properties by regulating their rates of activation, deactivation and desensitization
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Genomic Viewsfor CNIH3 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000001.10 NC_018912.1 NT_167186.1 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the CNIH3 gene promoter: NF-AT NF-AT4 NF-AT2 HSF2 FOXO4 FOXJ2 (long isoform) NF-AT3 FOXJ2 NF-AT1 Other transcription factors Search SABiosciences Chromatin IP Primers for CNIH3 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat CNIH3
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 1q42.12 Ensembl cytogenetic band: 1q42.12 HGNC cytogenetic band: 1q42.12 CNIH3 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 1 GeneLoc Exon Structure
GeneLoc location for GC01P224622: view genomic region
(about GC identifiers )
Start:
224,622,362 bp from pter
End:
224,928,251 bp from pter
Size:
305,890 bases
Orientation:
plus strand
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Proteinsfor CNIH3 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: CNIH3_HUMAN, Q8TBE1 (See
protein sequence )Recommended Name: Protein cornichon homolog 3 Size : 160 amino acids; 18976 Da
Subunit : Acts as an auxiliary subunit for AMPA-selective glutamate receptors (AMPARs). Found in a complex with GRIA1,GRIA2, GRIA3, GRIA4, CNIH2, CACNG2, CACNG3, CACNG4, CACNG5, CACNG7 and CACNG8 (By similarity)
Subcellular location : Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein (By similarity).Note=Also localizes to the cell membrane of extrasynaptic sites (dendritic shafts, spines of pyramidal cells) (By similarity) Explore the universe of human proteins at neXtProt for CNIH3: NX_Q8TBE1 CNIH3 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_689708.1 ENSEMBL proteins: ENSP00000272133 Human Recombinant Protein Products: Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005622 intracellular
-- -- GO:0030054 cell junction
IEA -- GO:0032281 alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex
ISS -- GO:0043198 dendritic shaft
ISS -- GO:0045211 postsynaptic membrane
ISS --
CNIH3 for ontologies About GeneDecksing CNIH3 Antibody Products: Assay Products for CNIH3:
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Protein
Domains / Familiesfor CNIH3 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
CNIH3 for domains About GeneDecksing 1 InterPro domain/family :
Graphical View of Domain Structure for InterPro Entry Q8TBE1 ProtoNet protein and cluster: Q8TBE1
1 Blocks protein family : IPB003377 Cornichon UniProtKB/Swiss-Prot: CNIH3_HUMAN, Q8TBE1 Similarity : Belongs to the cornichon family
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Functionfor CNIH3 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: CNIH3_HUMAN, Q8TBE1 Function : Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotestheir targeting to the cell membrane and synapses and modulates their gating properties by regulating their rates of activation, deactivation and desensitization
Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for CNIH3 (see all 4 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for CNIH3OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: CNIH3 (NM_152495 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CNIH3 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat CNIH3
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CNIH3
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0016247 channel regulator activity
IEA --
CNIH3 for ontologies About GeneDecksing
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Pathways & Interactionsfor CNIH3 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CNIH3 STRING Interaction
Network Preview (showing 5 interactants - click image to see 24)5/24 Interacting proteins for CNIH3 (ENSP00000272133 4 ) via UniProtKB, MINT, STRING , and/or I2D (see all 24 )About this table Gene Ontology (GO): 4 biological process terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0035249 synaptic transmission, glutamatergic
IEA -- GO:0035556 intracellular signal transduction
IEA -- GO:0042391 regulation of membrane potential
IEA -- GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity
IDA --
CNIH3 for ontologies About GeneDecksing
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Drugs & Compoundsfor CNIH3 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for CNIH3 Search CenterWatch for drugs/clinical trials and news about CNIH3
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Transcriptsfor CNIH3 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for CNIH3 gene: NM_152495.1 Unigene Cluster for CNIH3:
Cornichon homolog 3 (Drosophila) Hs.731723 [show with all ESTs ] Unigene Representative Sequence: AK096312 14 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000471578 ENST00000483512 ENST00000498126 ENST00000496372 ENST00000470602 ENST00000498382 ENST00000478120 ENST00000481095 ENST00000470788 ENST00000489556 ENST00000496277 ENST00000492470 ENST00000479227 ENST00000272133 (uc001hos.1 )Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for CNIH3 (see all 4 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for CNIH3OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: CNIH3 (NM_152495 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CNIH3 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat CNIH3
Additional cDNA sequence: AF070524.1 AK096312.1 BC022780.1
10 DOTS entries : DT.75143927 DT.121397937
DT.121397909 DT.121397907 DT.100768140 DT.99993103 DT.121397886 DT.91722717 DT.40284695 DT.75193446 24/80 AceView cDNA sequences (see all 80 ):
CR595048 BU947589 AK096312 CK822707 CB141048 BF593434 AF070524 BM509970 BM972532 NM_152495 CR625980 AL121016 BM906927 AW613067 BE878711 BM503825 F03694 BF434947 BF315626 BX092428 Z40078 BG115396 BG766095 BU194016 GeneLoc Exon Structure
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Expression for CNIH3 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section CNIH3 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: ATCAAGGTGT
About this image CNIH3 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table See CNIH3 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for CNIH3 SOURCE GeneReport for Unigene cluster: Hs.731723 SABiosciences Custom PCR Arrays for CNIH3 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for CNIH3Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat CNIH3 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat CNIH3 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat CNIH3 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CNIH3
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Orthologsfor CNIH3 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of eukaryotes.
Orthologs for CNIH3 gene from 7/24 species (see all 24 ) About this table
ENSEMBL Gene Tree for CNIH3 (if available)TreeFam Gene Tree for CNIH3 (if available)
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Paralogsfor CNIH3 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for CNIH3 gene CNIH 2 CNIH4 2 CNIH2 2 3 SIMAP similar genes for CNIH3 using alignment to 1 protein entry: CNIH3_HUMAN :CNIH2 CNIH CNIH4
CNIH3 for paralogs About GeneDecksing
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Genomic Variantsfor CNIH3 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 1 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for CNIH3 (224622362 - 224872362 bp, first 250kb of CNIH3)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 2 variations for CNIH3 1 CNV : 71335 1 Indel : 71340
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing CNIH3
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Disorders
/ Diseasesfor CNIH3 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section CNIH3 for disorders About MalaCards
CNIH3 for disorders About GeneDecksing Human Genome Epidemiology (HuGE) Navigator: CNIH3 (1 document)Export disorders for CNIH3 gene to outside databases
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Publicationsfor CNIH3 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for CNIH3 gene integrated from 9 sources : (articles sorted by number of sources associating them with CNIH3) Utopia : connect your pdf to the dynamic world of online information
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414) 1 , 2 Gregory S.G.... Bentley D.R. (2006) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 1 , 2 Ota T.... Sugano S. (2004) Large-scale concatenation cDNA sequencing. (PubMed id 9110174) 1 , 3 Yu W.... Gibbs R.A. (1997) A "double adaptor" method for improved shotgun library construction. (PubMed id 8619474) 1 , 3 Andersson B.... Gibbs R.A. (1996) Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614) 1 Rose J.E....Uhl G.R. (2010) Functional comparison of the effects of TARPs and cornichons on AMPA receptor trafficking and gating. (PubMed id 20805473) 2 Shi Y....Nicoll R.A. (2010) hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965) 1 Lamesch P.... Vidal M. (2007) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 Strausberg R.L....Marra M.A. (2002)
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External Searches for CNIH3 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing CNIH3 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing CNIH3 gene
(According to HUGE )
About This Section --
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Specialized Databases showing CNIH3 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for CNIH3 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for CNIH3 gene: Search GeneIP for patents involving CNIH3 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor CNIH3 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for CNIH3 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for CNIH3 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for CNIH3 OriGene Protein Over-expression Lysate for CNIH3 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for CNIH3 OriGene 3'-UTR Clone for CNIH3 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for CNIH3 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for CNIH3 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs OriGene Purified Protein for CNIH3 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for CNIH3 OriGene Custom Protein Services for CNIH3 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CNIH3 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing CNIH3 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat CNIH3 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat CNIH3 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat CNIH3 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat CNIH3
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CNIH3 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CNIH3
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Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat CNIH3
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Aliases for CNIH3
Databases for CNIH3
Disorders / Diseases for CNIH3
Domains / Families for CNIH3
Drugs / Compounds for CNIH3
Expression for CNIH3
Function for CNIH3
Genomic Views for CNIH3
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Orthologs for CNIH3
Paralogs for CNIH3
Pathways / Interactions for CNIH3
Products for CNIH3
Proteins for CNIH3
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Search Box for CNIH3
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Transcripts for CNIH3
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