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Aliases for CNIH3 Gene

Aliases for CNIH3 Gene

  • Cornichon Family AMPA Receptor Auxiliary Protein 3 2 3 4
  • CNIH-3 3 4
  • Cornichon Homolog 3 (Drosophila) 2
  • Cornichon Homolog 3 3

External Ids for CNIH3 Gene

Previous GeneCards Identifiers for CNIH3 Gene

  • GC01P221111
  • GC01P222870
  • GC01P224622
  • GC01P195324

Summaries for CNIH3 Gene

GeneCards Summary for CNIH3 Gene

CNIH3 (Cornichon Family AMPA Receptor Auxiliary Protein 3) is a Protein Coding gene. Diseases associated with CNIH3 include schizophrenia. Among its related pathways are Transport to the Golgi and subsequent modification and Vesicle-mediated transport. GO annotations related to this gene include channel regulator activity. An important paralog of this gene is CNIH4.

UniProtKB/Swiss-Prot for CNIH3 Gene

  • Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by regulating their rates of activation, deactivation and desensitization.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CNIH3 Gene

Genomics for CNIH3 Gene

Regulatory Elements for CNIH3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CNIH3 Gene

Chromosome:
1
Start:
224,434,660 bp from pter
End:
224,740,567 bp from pter
Size:
305,908 bases
Orientation:
Plus strand

Genomic View for CNIH3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CNIH3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CNIH3 Gene

Proteins for CNIH3 Gene

  • Protein details for CNIH3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TBE1-CNIH3_HUMAN
    Recommended name:
    Protein cornichon homolog 3
    Protein Accession:
    Q8TBE1

    Protein attributes for CNIH3 Gene

    Size:
    160 amino acids
    Molecular mass:
    18976 Da
    Quaternary structure:
    • Acts as an auxiliary subunit for AMPA-selective glutamate receptors (AMPARs). Found in a complex with GRIA1, GRIA2, GRIA3, GRIA4, CNIH2, CACNG2, CACNG3, CACNG4, CACNG5, CACNG7 and CACNG8 (By similarity).

neXtProt entry for CNIH3 Gene

Proteomics data for CNIH3 Gene at MOPED

Post-translational modifications for CNIH3 Gene

No Post-translational modifications

Other Protein References for CNIH3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CNIH3 Gene

Domains & Families for CNIH3 Gene

Protein Domains for CNIH3 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for CNIH3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TBE1

UniProtKB/Swiss-Prot:

CNIH3_HUMAN :
  • Belongs to the cornichon family.
Family:
  • Belongs to the cornichon family.
genes like me logo Genes that share domains with CNIH3: view

No data available for Gene Families for CNIH3 Gene

Function for CNIH3 Gene

Molecular function for CNIH3 Gene

UniProtKB/Swiss-Prot Function:
Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by regulating their rates of activation, deactivation and desensitization.

Gene Ontology (GO) - Molecular Function for CNIH3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016247 channel regulator activity IEA --
genes like me logo Genes that share ontologies with CNIH3: view

Phenotypes for CNIH3 Gene

genes like me logo Genes that share phenotypes with CNIH3: view

Animal Model Products

miRNA for CNIH3 Gene

miRTarBase miRNAs that target CNIH3

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for CNIH3 Gene

Localization for CNIH3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CNIH3 Gene

Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Note=Also localizes to the cell membrane of extrasynaptic sites (dendritic shafts, spines of pyramidal cells). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CNIH3 Gene COMPARTMENTS Subcellular localization image for CNIH3 gene
Compartment Confidence
plasma membrane 4

Gene Ontology (GO) - Cellular Components for CNIH3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005622 intracellular --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0012507 ER to Golgi transport vesicle membrane TAS --
GO:0016020 membrane --
genes like me logo Genes that share ontologies with CNIH3: view

Pathways & Interactions for CNIH3 Gene

genes like me logo Genes that share pathways with CNIH3: view

Interacting Proteins for CNIH3 Gene

Gene Ontology (GO) - Biological Process for CNIH3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006888 ER to Golgi vesicle-mediated transport TAS --
GO:0018279 protein N-linked glycosylation via asparagine TAS --
GO:0035249 synaptic transmission, glutamatergic IEA --
GO:0035556 intracellular signal transduction IEA --
GO:0042391 regulation of membrane potential IEA --
genes like me logo Genes that share ontologies with CNIH3: view

No data available for SIGNOR curated interactions for CNIH3 Gene

Drugs & Compounds for CNIH3 Gene

No Compound Related Data Available

Transcripts for CNIH3 Gene

Unigene Clusters for CNIH3 Gene

Cornichon homolog 3 (Drosophila):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CNIH3 Gene

No ASD Table

Relevant External Links for CNIH3 Gene

GeneLoc Exon Structure for
CNIH3
ECgene alternative splicing isoforms for
CNIH3

Expression for CNIH3 Gene

mRNA expression in normal human tissues for CNIH3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CNIH3 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x5.0), Brain - Anterior cingulate cortex (BA24) (x5.0), Brain - Cortex (x4.7), and Brain - Hippocampus (x4.2).

Protein differential expression in normal tissues from HIPED for CNIH3 Gene

This gene is overexpressed in Pancreas (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CNIH3 Gene



SOURCE GeneReport for Unigene cluster for CNIH3 Gene Hs.731723

mRNA Expression by UniProt/SwissProt for CNIH3 Gene

Q8TBE1-CNIH3_HUMAN
Tissue specificity: Expression is up-regulated in dorsolateral prefrontal cortex of patients with schizophrenia (postmortem brain study).
genes like me logo Genes that share expression patterns with CNIH3: view

Protein tissue co-expression partners for CNIH3 Gene

- Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

Orthologs for CNIH3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CNIH3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CNIH3 35
  • 93.75 (n)
  • 99.37 (a)
CNIH3 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CNIH3 35
  • 90.83 (n)
  • 96.87 (a)
CNIH3 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cnih3 35
  • 91.04 (n)
  • 100 (a)
Cnih3 16
Cnih3 36
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CNIH3 35
  • 99.17 (n)
  • 100 (a)
CNIH3 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cnih3 35
  • 92.71 (n)
  • 99.37 (a)
oppossum
(Monodelphis domestica)
Mammalia CNIH3 36
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CNIH3 36
  • 97 (a)
OneToOne
chicken
(Gallus gallus)
Aves CNIH3 35
  • 84.58 (n)
  • 98.12 (a)
CNIH3 36
  • 98 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CNIH3 36
  • 94 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cnih3 35
  • 80.62 (n)
  • 92.5 (a)
zebrafish
(Danio rerio)
Actinopterygii cnih3 35
  • 77 (n)
  • 82.28 (a)
cnih3 36
  • 81 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta cni 36
  • 53 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea cni-1 36
  • 52 (a)
ManyToMany
Y64H9A.1 36
  • 52 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ERV14 36
  • 28 (a)
ManyToMany
ERV15 36
  • 25 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5635 36
  • 67 (a)
OneToMany
Species with no ortholog for CNIH3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CNIH3 Gene

ENSEMBL:
Gene Tree for CNIH3 (if available)
TreeFam:
Gene Tree for CNIH3 (if available)

Paralogs for CNIH3 Gene

Paralogs for CNIH3 Gene

(4) SIMAP similar genes for CNIH3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CNIH3: view

Variants for CNIH3 Gene

Sequence variations from dbSNP and Humsavar for CNIH3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs169888 -- 224,651,380(+) ACATA(A/G)TTGAT intron-variant
rs177121 -- 224,657,071(+) GGTCT(C/T)GATAT intron-variant
rs192725 -- 224,651,564(+) TCTTA(C/T)ATAAA intron-variant
rs298730 -- 224,653,542(+) AATGG(A/G)GTTTT intron-variant
rs298731 -- 224,654,251(+) GGTGG(C/T)GCACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CNIH3 Gene

Variant ID Type Subtype PubMed ID
dgv102n67 CNV Loss 20364138
esv2670242 CNV Deletion 23128226
esv2723761 CNV Deletion 23290073
esv26044 CNV Loss 19812545
nsv524125 CNV Gain 19592680
esv24936 CNV Gain 19812545

Variation tolerance for CNIH3 Gene

Residual Variation Intolerance Score: 57.27% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.47; 10.23% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CNIH3 Gene

HapMap Linkage Disequilibrium report
CNIH3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CNIH3 Gene

Disorders for CNIH3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CNIH3 Gene - From: GeneCards

Disorder Aliases PubMed IDs
schizophrenia
  • schizophrenia 12
- elite association
Search CNIH3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CNIH3

Genetic Association Database (GAD)
CNIH3
Human Genome Epidemiology (HuGE) Navigator
CNIH3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CNIH3
genes like me logo Genes that share disorders with CNIH3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CNIH3 Gene

Publications for CNIH3 Gene

  1. Large-scale concatenation cDNA sequencing. (PMID: 9110174) Yu W. … Gibbs R.A. (Genome Res. 1997) 2 67
  2. A "double adaptor" method for improved shotgun library construction. (PMID: 8619474) Andersson B. … Gibbs R.A. (Anal. Biochem. 1996) 2 67
  3. Upregulation of cornichon transcripts in the dorsolateral prefrontal cortex in schizophrenia. (PMID: 23103966) Drummond J.B. … Meador-Woodruff J.H. (Neuroreport 2012) 67
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 67
  5. Functional comparison of the effects of TARPs and cornichons on AMPA receptor trafficking and gating. (PMID: 20805473) Shi Y. … Nicoll R.A. (Proc. Natl. Acad. Sci. U.S.A. 2010) 67

Products for CNIH3 Gene

Sources for CNIH3 Gene

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