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CNIH2 Gene

protein-coding   GIFtS: 46
GCID: GC11P066045

Cornichon Family AMPA Receptor Auxiliary Protein 2

(Previous name: cornichon homolog 2 (Drosophila))
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cornichon Family AMPA Receptor Auxiliary Protein 21 2 3     Cnil2
CNIH-22 3     Cornichon Homolog 22
CNIL3 5     Protein Cornichon Homolog 22
Cornichon Homolog 2 (Drosophila)1     Cornichon-Like Protein3

External Ids:    HGNC: 287441   Entrez Gene: 2542632   Ensembl: ENSG000001748717   OMIM: 6112885   UniProtKB: Q6PI253   

Export aliases for CNIH2 gene to outside databases

Previous GC identifers: GC11P065803 GC11P062375


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CNIH2 Gene:
The protein encoded by this gene is an auxiliary subunit of the ionotropic glutamate receptor of the AMPA subtype.
AMPA receptors mediate fast synaptic neurotransmission in the central nervous system. This protein has been
reported to interact with the Type I AMPA receptor regulatory protein isoform gamma-8 to control assembly of
hippocampal AMPA receptor complexes, thereby modulating receptor gating and pharmacology. Alternative splicing
results in multiple transcript variants. (provided by RefSeq, Aug 2012)

GeneCards Summary for CNIH2 Gene:
CNIH2 (cornichon family AMPA receptor auxiliary protein 2) is a protein-coding gene. An important paralog of this gene is CNIH1.

UniProtKB/Swiss-Prot: CNIH2_HUMAN, Q6PI25
Function: Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes
their targeting to the cell membrane and synapses and modulates their gating properties by regulating their rates
of activation, deactivation and desensitization. Blocks CACNG8-mediated resensitization of AMPA receptors




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NC_018922.2  NT_167190.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CNIH2 gene promoter:
         MAZR   Tal-1beta   LCR-F1   E47   RORalpha2   c-Ets-1   AREB6   Pax-4a   Ik-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCNIH2 promoter sequence
   Search Chromatin IP Primers for CNIH2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CNIH2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13.2   Ensembl cytogenetic band:  11q13.2   HGNC cytogenetic band: 11q13.2

CNIH2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CNIH2 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P066045:  view genomic region     (about GC identifiers)

Start:
66,045,661 bp from pter      End:
66,052,772 bp from pter
Size:
7,112 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CNIH2_HUMAN, Q6PI25 (See protein sequence)
Recommended Name: Protein cornichon homolog 2  
Size: 160 amino acids; 18931 Da
Subunit: Acts as an auxiliary subunit for AMPA-selective glutamate receptors (AMPARs). Found in a complex with
GRIA1, GRIA2, GRIA3, GRIA4, CNIH3, CACNG2, CACNG3, CACNG4, CACNG5, CACNG7 and CACNG8 (By similarity). Interacts
with CACGN8 (By similarity). Interacts with GRIA1

Explore the universe of human proteins at neXtProt for CNIH2: NX_Q6PI25

Explore proteomics data for CNIH2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CNIH2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_872359.1  
    ENSEMBL proteins: 
     ENSP00000432177   ENSP00000310003   ENSP00000433896   ENSP00000435537  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR003377 Cornichon

    Graphical View of Domain Structure for InterPro Entry Q6PI25

    ProtoNet protein and cluster: Q6PI25

    1 Blocks protein domain: IPB003377 Cornichon

    UniProtKB/Swiss-Prot: CNIH2_HUMAN, Q6PI25
    Similarity: Belongs to the cornichon family


    Find genes that share domains with CNIH2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CNIH2_HUMAN, Q6PI25
    Function: Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes
    their targeting to the cell membrane and synapses and modulates their gating properties by regulating their rates
    of activation, deactivation and desensitization. Blocks CACNG8-mediated resensitization of AMPA receptors

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
         
    Find genes that share ontologies with CNIH2           About GenesLikeMe


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Cnih2):
     nervous system  normal 

    Find genes that share phenotypes with CNIH2           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for CNIH2

    miRNA
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    miRTarBase miRNAs that target CNIH2:
    hsa-mir-335-5p (MIRT017758)

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    Selected qRT-PCR Assays for microRNAs that regulate CNIH2 (see all 38):
    hsa-miR-596 hsa-miR-199a-3p hsa-miR-1224-3p hsa-miR-15a hsa-miR-486-3p hsa-miR-4314 hsa-miR-1244 hsa-miR-424
    SwitchGear 3'UTR luciferase reporter plasmidCNIH2 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CNIH2_HUMAN, Q6PI25: Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Cell junction,
    synapse, postsynaptic cell membrane; Multi-pass membrane protein (By similarity). Cell projection, dendrite (By
    similarity). Cell projection, dendritic spine (By similarity). Cell junction, synapse, postsynaptic cell
    membrane, postsynaptic density (By similarity). Note=Also localizes to the cell membrane of extrasynaptic sites
    (dendritic shafts, spines of pyramidal cells) (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    cytoskeleton4
    plasma membrane4
    extracellular2

    Gene Ontology (GO): Selected cellular component terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0014069postsynaptic density ISS--
    GO:0016020membrane ----
    GO:0030054cell junction IEA--
    GO:0030425dendrite ISS--

    Find genes that share ontologies with CNIH2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CNIH2
    Interactions:

        Search GeneGlobe Interaction Network for CNIH2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CNIH2 (ENSP000003100034) via UniProtKB, MINT, STRING, and/or I2D (see all 32)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CACNG3ENSP000000052844STRING: ENSP00000005284
    CACNG4ENSP000002621384STRING: ENSP00000262138
    CACNG5ENSP000001695654STRING: ENSP00000169565
    CACNG7ENSP000002222124STRING: ENSP00000222212
    CNIH3ENSP000002721334STRING: ENSP00000272133
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0035249synaptic transmission, glutamatergic IEA--
    GO:0035556intracellular signal transduction IEA--
    GO:0042391regulation of membrane potential IEA--
    GO:0051668localization within membrane IEA--
    GO:2000311regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity IDA--

    Find genes that share ontologies with CNIH2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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      Browse compounds at ApexBio 

    Browse Tocris compounds for CNIH2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CNIH2 gene: 
    NM_182553.2  

    Unigene Cluster for CNIH2:

    Cornichon homolog 2 (Drosophila)
    Hs.437072  [show with all ESTs]
    Unigene Representative Sequence: BC047953
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000528852 ENST00000311445(uc001ohi.1 uc009yrb.1) ENST00000534826
    ENST00000528063 ENST00000530519 ENST00000531936
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    hsa-miR-596 hsa-miR-199a-3p hsa-miR-1224-3p hsa-miR-15a hsa-miR-486-3p hsa-miR-4314 hsa-miR-1244 hsa-miR-424
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    Additional mRNA sequence: 

    AY726585.1 BC047953.1 NR_073078.1 NR_073079.1 

    6 DOTS entries:

    DT.207733  DT.95087168  DT.100754101  DT.100754100  DT.120735053  DT.120735114 

    Selected AceView cDNA sequences (see all 60):

    CK904941 CR610128 BM547951 BM055396 BQ100766 NM_182553 BU176624 BC047953 
    CR594991 BI963773 BI829816 BM126848 BM928404 BX092166 CB305929 AI362784 
    BX394469 BM126277 AI934864 BM054760 BQ101053 BI789272 BM672358 M78733 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CNIH2 (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d · 7e
    SP1:        -           -     -                                                         
    SP2:        -           -     -                                                         
    SP3:        -                 -                                                         
    SP4:        -           -     -                                                         
    SP5:                    -     -                                                         


    ECgene alternative splicing isoforms for CNIH2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CNIH2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCAGTCATTC
    CNIH2 Expression
    About this image


    CNIH2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Bone (Muscoskeletal System)
             Membranous Facial Bones
     
     Pancreas (Endocrine System)
    CNIH2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CNIH2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.437072

    UniProtKB/Swiss-Prot: CNIH2_HUMAN, Q6PI25
    Tissue specificity: Expression is up-regulated in dorsolateral prefrontal cortex of patients with schizophrenia
    (postmortem brain study)

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for CNIH2 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cnih21 , 5 cornichon homolog 2 (Drosophila)1, 5 97.29(n)1
    100(a)1
      19 (4.24 cM)5
    127941  NM_009920.31  NP_034050.11 
     50928715 
    lizard
    (Anolis carolinensis)
    Reptilia CNIH26
    cornichon family AMPA receptor auxiliary protein 2...
    98(a)
    1 ↔ 1
    GL343519.1(26457-73538)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.171562 Xenopus laevis transcribed sequence with weak similarity more 78.45(n)    CD361746.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.151312 Transcribed sequence with weak similarity to protein more 83.84(n)    BM082369.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta cni6
    cornichon
    53(a)
    1 → many
    2L(16309594-16310736)
    worm
    (Caenorhabditis elegans)
    Secernentea cni-16
    Y64H9A.16
    Protein Y64H9A.1 (Y64H9A.1) mRNA, complete cds
    50(a)
    46(a)
    many ↔ many
    many ↔ many
    V(13180330-13181529) WBGene00011648
    X(5057363-5057581) WBGene00022023
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ERV146
    ERV156
    Protein localized to COPII-coated vesicles, involv...
    Protein involved in export of proteins from the en...
    32(a)
    28(a)
    many ↔ many
    many ↔ many
    VII(400871-401287) YGL054C
    II(645550-645978) YBR210W


    ENSEMBL Gene Tree for CNIH2 (if available)
    TreeFam Gene Tree for CNIH2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    Paralogs for CNIH2 gene
    CNIH12  CNIH32  CNIH42  
    3 SIMAP similar genes for CNIH2 using alignment to 4 protein entries:     CNIH2_HUMAN (see all proteins):
    CNIH3    CNIH1    CNIH

    Find genes that share paralogs with CNIH2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CNIH2 (see all 131)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1172268721,2
    C,F--66045546(+) TTGTCG/TGGGCT 3 -- us2k11Minor allele frequency- T:0.28NA 120
    rs1469372071,2
    C,F--66045948(+) GCCGCG/ATTCTG 4 /A syn11Minor allele frequency- A:0.00NA 3790
    rs1378717201,2
    C,F--66045957(+) TGCTAC/TATGCT 4 Y syn11Minor allele frequency- T:0.01NA 3920
    rs1821624641,2
    C--66045979(+) TGTGCA/GCCTCC 4 T A mis10--------
    rs2013051511,2
    --66046017(+) AGGCCC/GGGCTG 3 -- int10--------
    rs1433579021,2
    C--66046337(+) CCCAC-/CACCAT
            
    CCAGC
    3 -- int10--------
    rs1999135711,2
    C--66046400(-) AAAGGC/GGNNNN 3 -- int10--------
    rs1868506221,2
    --66046493(+) TTAACC/GCTTTG 3 -- int10--------
    rs1403435741,2
    --66046503(+) GCCTTA/CCCAGC 3 -- int10--------
    rs1909716561,2
    C--66046529(+) GCAGCA/CGTTGG 3 -- int10--------

    HapMap Linkage Disequilibrium report for CNIH2 (66045661 - 66052772 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for CNIH2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv897772CNV Loss21882294
    dgv1187n71CNV Loss21882294
    nsv897779CNV Loss21882294
    dgv1188n71CNV Loss21882294
    nsv825956CNV Gain20364138

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611288    OMIM disorders: --


    Find genes that share disorders with CNIH2           About GenesLikeMe


    Export disorders for CNIH2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CNIH2 gene, integrated from 10 sources (see all 12):
    (articles sorted by number of sources associating them with CNIH2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Upregulation of cornichon transcripts in the dorsolateral prefrontal cortex in schizophrenia. (PubMed id 23103966)1, 2 Drummond J.B....Meador-Woodruff J.H. (Neuroreport 2012)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    4. Cornichons modify channel properties of recombinant and glial AMPA receptors. (PubMed id 22815494)1 Coombs I.D....Cull-Candy S.G. (J. Neurosci. 2012)
    5. AMPA receptor modulation by cornichon-2 dictated by transmembrane AMPA receptor regulatory protein isoform. (PubMed id 22211840)1 Gill M.B....Bredt D.S. (Eur. J. Neurosci. 2012)
    6. Cornichon-2 modulates AMPA receptor-transmembrane AMPA receptor regulatory protein assembly to dictate gating and pharmacology. (PubMed id 21543622)1 Gill M.B....Bredt D.S. (J. Neurosci. 2011)
    7. Transmembrane AMPA receptor regulatory proteins and cornichon-2 allosterically regulate AMPA receptor antagonists and potentiators. (PubMed id 21343286)1 Schober D.A....Bredt D.S. (J. Biol. Chem. 2011)
    8. Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4. (PubMed id 21926972)1 (Nat. Genet. 2011)
    9. Hippocampal AMPA receptor gating controlled by both TARP and cornichon proteins. (PubMed id 21172611)1 Kato A.S.... Bredt D.S. (Neuron 2010)
    10. Functional comparison of the effects of TARPs and cornichons on AMPA receptor trafficking and gating. (PubMed id 20805473)2 Shi Y....Nicoll R.A. (Proc. Natl. Acad. Sci. U.S.A. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 254263 HGNC: 28744 AceView: MGC50896 Ensembl:ENSG00000174871 euGenes: HUgn254263
    ECgene: CNIH2 H-InvDB: CNIH2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CNIH2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CNIH2 gene:
    Search GeneIP for patents involving CNIH2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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