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Aliases for CNIH2 Gene

Aliases for CNIH2 Gene

  • Cornichon Family AMPA Receptor Auxiliary Protein 2 2 3 4
  • Cnil 3 4 6
  • CNIH-2 3 4
  • Cornichon Homolog 2 (Drosophila) 2
  • Protein Cornichon Homolog 2 3
  • Cornichon-Like Protein 4
  • Cornichon Homolog 2 3

External Ids for CNIH2 Gene

Previous GeneCards Identifiers for CNIH2 Gene

  • GC11P065803
  • GC11P066045
  • GC11P062375

Summaries for CNIH2 Gene

Entrez Gene Summary for CNIH2 Gene

  • The protein encoded by this gene is an auxiliary subunit of the ionotropic glutamate receptor of the AMPA subtype. AMPA receptors mediate fast synaptic neurotransmission in the central nervous system. This protein has been reported to interact with the Type I AMPA receptor regulatory protein isoform gamma-8 to control assembly of hippocampal AMPA receptor complexes, thereby modulating receptor gating and pharmacology. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

GeneCards Summary for CNIH2 Gene

CNIH2 (Cornichon Family AMPA Receptor Auxiliary Protein 2) is a Protein Coding gene. An important paralog of this gene is CNIH4.

UniProtKB/Swiss-Prot for CNIH2 Gene

  • Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by regulating their rates of activation, deactivation and desensitization. Blocks CACNG8-mediated resensitization of AMPA receptors.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CNIH2 Gene

Genomics for CNIH2 Gene

Regulatory Elements for CNIH2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CNIH2 Gene

Start:
66,278,190 bp from pter
End:
66,285,301 bp from pter
Size:
7,112 bases
Orientation:
Plus strand

Genomic View for CNIH2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CNIH2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CNIH2 Gene

Proteins for CNIH2 Gene

  • Protein details for CNIH2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6PI25-CNIH2_HUMAN
    Recommended name:
    Protein cornichon homolog 2
    Protein Accession:
    Q6PI25
    Secondary Accessions:

    Protein attributes for CNIH2 Gene

    Size:
    160 amino acids
    Molecular mass:
    18931 Da
    Quaternary structure:
    • Acts as an auxiliary subunit for AMPA-selective glutamate receptors (AMPARs). Found in a complex with GRIA1, GRIA2, GRIA3, GRIA4, CNIH3, CACNG2, CACNG3, CACNG4, CACNG5, CACNG7 and CACNG8 (By similarity). Interacts with CACGN8 (By similarity). Interacts with GRIA1.

neXtProt entry for CNIH2 Gene

Proteomics data for CNIH2 Gene at MOPED

Post-translational modifications for CNIH2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CNIH2 Gene

No data available for DME Specific Peptides for CNIH2 Gene

Domains for CNIH2 Gene

Protein Domains for CNIH2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for CNIH2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6PI25

UniProtKB/Swiss-Prot:

CNIH2_HUMAN :
  • Q6PI25
Family:
  • Belongs to the cornichon family.
genes like me logo Genes that share domains with CNIH2: view

No data available for Gene Families for CNIH2 Gene

Function for CNIH2 Gene

Molecular function for CNIH2 Gene

UniProtKB/Swiss-Prot Function: Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by regulating their rates of activation, deactivation and desensitization. Blocks CACNG8-mediated resensitization of AMPA receptors.

Gene Ontology (GO) - Molecular Function for CNIH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20805473
genes like me logo Genes that share ontologies with CNIH2: view

Phenotypes for CNIH2 Gene

genes like me logo Genes that share phenotypes with CNIH2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CNIH2 TF3277 Cnih

CRISPR Products

miRNA for CNIH2 Gene

miRTarBase miRNAs that target CNIH2

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CNIH2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for CNIH2 Gene

Localization for CNIH2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CNIH2 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell projection, dendrite. Cell projection, dendritic spine. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Note=Also localizes to the cell membrane of extrasynaptic sites (dendritic shafts, spines of pyramidal cells). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CNIH2 Gene COMPARTMENTS Subcellular localization image for CNIH2 gene
Compartment Confidence
endoplasmic reticulum 5
cytoskeleton 4
plasma membrane 4
extracellular 2

Gene Ontology (GO) - Cellular Components for CNIH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0014069 postsynaptic density ISS --
GO:0016020 membrane --
GO:0030054 cell junction IEA --
genes like me logo Genes that share ontologies with CNIH2: view

Pathways for CNIH2 Gene

SuperPathways for CNIH2 Gene

No Data Available

Interacting Proteins for CNIH2 Gene

Gene Ontology (GO) - Biological Process for CNIH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035249 synaptic transmission, glutamatergic IEA --
GO:0035556 intracellular signal transduction IEA --
GO:0042391 regulation of membrane potential IEA --
GO:0051668 localization within membrane IEA --
GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity IDA 20805473
genes like me logo Genes that share ontologies with CNIH2: view

No data available for Pathways by source for CNIH2 Gene

Transcripts for CNIH2 Gene

Unigene Clusters for CNIH2 Gene

Cornichon homolog 2 (Drosophila):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CNIH2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CNIH2 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d · 7e
SP1: - - -
SP2: - - -
SP3: - -
SP4: - - -
SP5: - -
SP6:

Relevant External Links for CNIH2 Gene

GeneLoc Exon Structure for
CNIH2
ECgene alternative splicing isoforms for
CNIH2

Expression for CNIH2 Gene

mRNA expression in normal human tissues for CNIH2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CNIH2 Gene

This gene is overexpressed in Brain - Hippocampus (11.0), Brain - Amygdala (5.4), Brain - Nucleus accumbens (basal ganglia) (4.7), Brain - Anterior cingulate cortex (BA24) (4.5), Brain - Putamen (basal ganglia) (4.4), and Brain - Caudate (basal ganglia) (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CNIH2 Gene

SOURCE GeneReport for Unigene cluster for CNIH2 Gene Hs.437072

mRNA Expression by UniProt/SwissProt for CNIH2 Gene

Q6PI25-CNIH2_HUMAN
Tissue specificity: Expression is up-regulated in dorsolateral prefrontal cortex of patients with schizophrenia (postmortem brain study).
genes like me logo Genes that share expressions with CNIH2: view

In Situ Assay Products

Orthologs for CNIH2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CNIH2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CNIH2 35
  • 99.79 (n)
  • 100 (a)
CNIH2 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CNIH2 35
  • 89.37 (n)
  • 88.75 (a)
CNIH2 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cnih2 35
  • 97.29 (n)
  • 100 (a)
Cnih2 16
Cnih2 36
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CNIH2 36
  • 55 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cnih2 35
  • 97.5 (n)
  • 100 (a)
lizard
(Anolis carolinensis)
Reptilia CNIH2 36
  • 98 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.17156 35
tropical clawed frog
(Silurana tropicalis)
Amphibia cnih2 35
  • 76.86 (n)
  • 89.81 (a)
zebrafish
(Danio rerio)
Actinopterygii cnih2 35
  • 80 (n)
  • 90 (a)
cnih2 36
  • 90 (a)
OneToOne
Dr.15131 35
fruit fly
(Drosophila melanogaster)
Insecta cni 36
  • 53 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea cni-1 36
  • 50 (a)
ManyToMany
Y64H9A.1 36
  • 46 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ERV14 36
  • 32 (a)
ManyToMany
ERV15 36
  • 28 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5635 36
  • 65 (a)
OneToMany
Species with no ortholog for CNIH2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CNIH2 Gene

ENSEMBL:
Gene Tree for CNIH2 (if available)
TreeFam:
Gene Tree for CNIH2 (if available)

Paralogs for CNIH2 Gene

Paralogs for CNIH2 Gene

Selected SIMAP similar genes for CNIH2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with CNIH2: view

Variants for CNIH2 Gene

Sequence variations from dbSNP and Humsavar for CNIH2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs948358 -- 66,280,052(-) AAAAG(A/G)GGCTT intron-variant
rs1783732 -- 66,280,643(-) GTCAC(C/G)CCTCC intron-variant
rs1789147 -- 66,282,026(-) CCCTT(C/T)CAAAA intron-variant
rs3016315 -- 66,283,477(-) CCTCA(A/G)GGGCA intron-variant
rs4073582 -- 66,283,241(+) TGTCT(A/G)CCCCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CNIH2 Gene

Variant ID Type Subtype PubMed ID
dgv1187n71 CNV Loss 21882294
nsv897772 CNV Loss 21882294
dgv1188n71 CNV Loss 21882294
nsv897779 CNV Loss 21882294
nsv825956 CNV Gain 20364138

Relevant External Links for CNIH2 Gene

HapMap Linkage Disequilibrium report
CNIH2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CNIH2 Gene

Disorders for CNIH2 Gene

No disorders were found for CNIH2 Gene.

No data available for UniProtKB/Swiss-Prot for CNIH2 Gene

Publications for CNIH2 Gene

  1. Functional comparison of the effects of TARPs and cornichons on AMPA receptor trafficking and gating. (PMID: 20805473) Shi Y. … Nicoll R.A. (Proc. Natl. Acad. Sci. U.S.A. 2010) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Upregulation of cornichon transcripts in the dorsolateral prefrontal cortex in schizophrenia. (PMID: 23103966) Drummond J.B. … Meador-Woodruff J.H. (Neuroreport 2012) 3 4
  4. Cornichon2 dictates the time course of excitatory transmission at individual hippocampal synapses. (PMID: 24853943) Boudkkazi S. … Fakler B. (Neuron 2014) 2 3
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3

Products for CNIH2 Gene

Sources for CNIH2 Gene

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