Aliases for CNIH2 Gene
External Ids for CNIH2 Gene
Previous GeneCards Identifiers for CNIH2 Gene
The protein encoded by this gene is an auxiliary subunit of the ionotropic glutamate receptor of the AMPA subtype. AMPA receptors mediate fast synaptic neurotransmission in the central nervous system. This protein has been reported to interact with the Type I AMPA receptor regulatory protein isoform gamma-8 to control assembly of hippocampal AMPA receptor complexes, thereby modulating receptor gating and pharmacology. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
GeneCards Summary for CNIH2 Gene
CNIH2 (Cornichon Family AMPA Receptor Auxiliary Protein 2) is a Protein Coding gene. Diseases associated with CNIH2 include Schizophrenia. Among its related pathways are Vesicle-mediated transport and Transport to the Golgi and subsequent modification. An important paralog of this gene is CNIH3.
UniProtKB/Swiss-Prot for CNIH2 Gene
Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by regulating their rates of activation, deactivation and desensitization. Blocks CACNG8-mediated resensitization of AMPA receptors.