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Aliases for CNIH1 Gene

Aliases for CNIH1 Gene

  • Cornichon Family AMPA Receptor Auxiliary Protein 1 2 3 4
  • TGAM77 3 4 6
  • CNIH 3 4 6
  • T-Cell Growth-Associated Molecule 77 3 4
  • CNIH-1 3 4
  • Cnil 3 4
  • Cornichon Homolog (Drosophila) 2
  • Protein Cornichon Homolog 1 3
  • Protein Cornichon Homolog 4
  • Cornichon Homolog 3

External Ids for CNIH1 Gene

Previous HGNC Symbols for CNIH1 Gene

  • CNIH

Previous GeneCards Identifiers for CNIH1 Gene

  • GC14M054894

Summaries for CNIH1 Gene

GeneCards Summary for CNIH1 Gene

CNIH1 (Cornichon Family AMPA Receptor Auxiliary Protein 1) is a Protein Coding gene. An important paralog of this gene is CNIH4.

UniProtKB/Swiss-Prot for CNIH1 Gene

  • Involved in the selective transport and maturation of TGF-alpha family proteins.

Gene Wiki entry for CNIH1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CNIH1 Gene

Genomics for CNIH1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CNIH1 Gene

54,423,560 bp from pter
54,441,531 bp from pter
17,972 bases
Minus strand

Genomic View for CNIH1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CNIH1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CNIH1 Gene

No data available for Regulatory Elements for CNIH1 Gene

Proteins for CNIH1 Gene

  • Protein details for CNIH1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein cornichon homolog 1
    Protein Accession:
    Secondary Accessions:
    • Q3SYM7

    Protein attributes for CNIH1 Gene

    144 amino acids
    Molecular mass:
    16699 Da
    Quaternary structure:
    • Interacts with AREG immature precursor and with immature TGFA, i.e. with a prosegment and lacking full N-glycosylation, but not with the fully N-glycosylated form. In the Golgi apparatus, may form a complex with GORASP55 and transmembrane TGFA.

neXtProt entry for CNIH1 Gene

Proteomics data for CNIH1 Gene at MOPED

Post-translational modifications for CNIH1 Gene

No Post-translational modifications

Other Protein References for CNIH1 Gene

No data available for DME Specific Peptides for CNIH1 Gene

Domains for CNIH1 Gene

Protein Domains for CNIH1 Gene


Graphical View of Domain Structure for InterPro Entry



  • Belongs to the cornichon family.
  • Belongs to the cornichon family.
genes like me logo Genes that share domains with CNIH1: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for CNIH1 Gene

Function for CNIH1 Gene

Molecular function for CNIH1 Gene

UniProtKB/Swiss-Prot Function:
Involved in the selective transport and maturation of TGF-alpha family proteins.

Phenotypes for CNIH1 Gene

genes like me logo Genes that share phenotypes with CNIH1: view

Animal Model Products

CRISPR Products

miRNA for CNIH1 Gene

miRTarBase miRNAs that target CNIH1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CNIH1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targets and HOMER Transcription for CNIH1 Gene

Localization for CNIH1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CNIH1 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane. Note=Located primarily in the ER; may cycle between the ER and the Golgi apparatus.

Gene Ontology (GO) - Cellular Components for CNIH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005783 endoplasmic reticulum --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0005794 Golgi apparatus --
GO:0016020 membrane --
genes like me logo Genes that share ontologies with CNIH1: view

No data available for Subcellular locations from COMPARTMENTS for CNIH1 Gene

Pathways for CNIH1 Gene

SuperPathways for CNIH1 Gene

No Data Available

Interacting Proteins for CNIH1 Gene

Gene Ontology (GO) - Biological Process for CNIH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006955 immune response TAS 10209299
GO:0007165 signal transduction TAS 10209299
GO:0016192 vesicle-mediated transport IEA --
GO:0035556 intracellular signal transduction IEA --
genes like me logo Genes that share ontologies with CNIH1: view

No data available for Pathways by source for CNIH1 Gene

Transcripts for CNIH1 Gene

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CNIH1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CNIH1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6
SP2: -
SP3: - -
SP4: - -
SP5: - -

Relevant External Links for CNIH1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CNIH1 Gene

mRNA expression in normal human tissues for CNIH1 Gene

Protein differential expression in normal tissues for CNIH1 Gene

This gene is overexpressed in Ovary (59.0) and Liver (6.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CNIH1 Gene

mRNA Expression by UniProt/SwissProt for CNIH1 Gene

Tissue specificity: Highly expressed in heart, liver, skeletal muscle, pancreas, adrenal medulla and cortex, thyroid, testis, spleen, appendix, peripheral blood lymphocytes and bone marrow. Lower expression found in brain, placenta, lung, kidney, ovary, small intestine, stomach, lymph node, thymus and fetal liver. Expression is up-regulated in dorsolateral prefrontal cortex of patients with schizophrenia (postmortem brain study).
genes like me logo Genes that share expressions with CNIH1: view

Expression partners for CNIH1 Gene

* - Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for CNIH1 Gene

Orthologs for CNIH1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CNIH1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CNIH1 35
  • 97.22 (n)
  • 100 (a)
  • 80 (a)
(Canis familiaris)
Mammalia CNIH1 35
  • 96.3 (n)
  • 100 (a)
CNIH1 36
  • 52 (a)
(Mus musculus)
Mammalia Cnih1 35
  • 91.9 (n)
  • 100 (a)
Cnih 16
Cnih1 36
  • 100 (a)
(Pan troglodytes)
Mammalia CNIH 35
  • 99.54 (n)
  • 100 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Cnih1 35
  • 93.52 (n)
  • 100 (a)
(Monodelphis domestica)
Mammalia CNIH1 36
  • 89 (a)
(Gallus gallus)
Aves CNIH 35
  • 89.81 (n)
  • 99.31 (a)
CNI 36
  • 99 (a)
(Anolis carolinensis)
Reptilia CNIH1 36
  • 89 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cnih1 35
  • 85.19 (n)
  • 98.61 (a)
Str.6297 35
(Danio rerio)
Actinopterygii cnih1 35
  • 80.09 (n)
  • 96.53 (a)
cnih1 36
  • 97 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008974 35
  • 63.66 (n)
  • 69.44 (a)
fruit fly
(Drosophila melanogaster)
Insecta cni 35
  • 60.88 (n)
  • 66.67 (a)
cni 36
  • 67 (a)
(Caenorhabditis elegans)
Secernentea cnih-2 35
  • 56.02 (n)
  • 59.03 (a)
cni-1 36
  • 59 (a)
Y64H9A.1 36
  • 57 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ERV14 36
  • 33 (a)
ERV15 36
  • 31 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2430 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5635 36
  • 80 (a)
Species with no ortholog for CNIH1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CNIH1 Gene

Gene Tree for CNIH1 (if available)
Gene Tree for CNIH1 (if available)

Paralogs for CNIH1 Gene

Paralogs for CNIH1 Gene

(4) SIMAP similar genes for CNIH1 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with CNIH1: view

Variants for CNIH1 Gene

Sequence variations from dbSNP and Humsavar for CNIH1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs1138757 -- 54,424,936(-) GTGAT(A/G)GGAAA downstream-variant-500B
rs2298078 -- 54,436,899(-) ATATC(G/T)ATGGC intron-variant
rs2358665 -- 54,439,662(+) CCTCC(A/G)CCTCA intron-variant
rs3759655 -- 54,442,019(+) TGGTG(A/T)GACTT upstream-variant-2KB
rs3759656 -- 54,442,408(+) GCTGA(C/T)GGAAG upstream-variant-2KB

Relevant External Links for CNIH1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CNIH1 Gene

Disorders for CNIH1 Gene

No disorders were found for CNIH1 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for CNIH1 Gene

Publications for CNIH1 Gene

  1. The human homolog of Drosophila cornichon protein is differentially expressed in alloactivated T-cells. (PMID: 10209299) Utku N. … Gullans S.R. (Biochim. Biophys. Acta 1999) 2 3 4
  2. Upregulation of cornichon transcripts in the dorsolateral prefrontal cortex in schizophrenia. (PMID: 23103966) Drummond J.B. … Meador-Woodruff J.H. (Neuroreport 2012) 3 4
  3. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 3 4
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for CNIH1 Gene

Sources for CNIH1 Gene

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