CNIH Gene
protein-coding GIFtS: 45
GCID: GC14M054893
|
|
cornichon homolog (Drosophila)
| |
Aliases
for CNIH gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Cornichon Homolog (Drosophila)1 2 | | CNIL1 2 3 | | TGAM771 2 3 | | CNIH11 2 | | T-Cell Growth-Associated Molecule 772 3 | | Protein Cornichon Homolog2 |
Export aliases for CNIH gene to outside databasesPrevious GC identifers: GC14M048689 GC14M052883 GC14M053963 GC14M035056 |
Summaries
for CNIH gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: CNIH_HUMAN, O95406Function: Involved in the selective transport and maturation of TGF-alpha family proteins
Gene Wiki entry for CNIH
|
Genomic Views
for CNIH gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000014.8 NC_018925.1 NT_026437.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CNIH gene promoter:
CBF-C GATA-1 CBF-A POU2F1 CBF-B POU2F1b POU2F1a POU2F1c CP1A NF-Y
Other transcription factors
Search SABiosciences Chromatin IP Primers for CNIH
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CNIH |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 14q22.2 Ensembl cytogenetic band: 14q22.2 HGNC cytogenetic band: 14q22.1CNIH Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 14 GeneLoc Exon Structure GeneLoc location for GC14M054893: view genomic region
(about GC identifiers)
Start:
|
54,893,647 bp from pter |
End:
|
54,908,149 bp from pter |
Size:
|
14,503 bases |
Orientation:
|
minus strand |
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Proteins
for CNIH gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CNIH_HUMAN, O95406 (See
protein sequence)Recommended Name: Protein cornichon homolog Size: 144 amino acids; 16699 Da
Subunit: Interacts with AREG immature precursor and with immature TGFA, i.e. with a prosegment and lacking fullN-glycosylation, but not with the fully N-glycosylated form. In the Golgi apparatus, may form a complex with GORASP55and transmembrane TGFA
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane.Note=Located primarily in the ER; may cycle between the ER and the Golgi apparatus
Secondary accessions: Q3SYM7Explore the universe of human proteins at neXtProt for CNIH: NX_O95406
CNIH Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_005767.1
ENSEMBL proteins: ENSP00000378940 ENSP00000216416 ENSP00000451640 ENSP00000452457 ENSP00000451852 ENSP00000452466 ENSP00000451142
Human Recombinant Protein Products:
Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table
CNIH for ontologies About GeneDecksing
CNIH Antibody Products:
Assay Products for CNIH: |
Protein
Domains /
Families
for CNIH gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CNIH for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry O95406ProtoNet protein and cluster: O95406 1 Blocks protein family: IPB003377 Cornichon
UniProtKB/Swiss-Prot: CNIH_HUMAN, O95406Similarity: Belongs to the cornichon family |
Function
for CNIH gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: CNIH_HUMAN, O95406Function: Involved in the selective transport and maturation of TGF-alpha family proteins
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CNIH (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CNIH
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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| |  | GenScript: all cDNA clones in your preferred vector: CNIH (NM_005776) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CNIH | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CNIH |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CNIH |
Animal Models:
2 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Cnih):
CNIH for phenotypes About GeneDecksing
|
Pathways & Interactions
for CNIH gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CNIH
STRING Interaction
Network Preview (showing 4 interactants - click image to see more details)
4 Interacting proteins for CNIH (ENSP000002164164) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table
CNIH for ontologies About GeneDecksing
|
Drugs & Compounds
for CNIH gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CNIH
Search CenterWatch for drugs/clinical trials and news about CNIH
|
Transcripts
for CNIH gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CNIH gene (2 alternative transcripts): NM_001009551.1 NM_005776.2 Unigene Cluster for CNIH: Cornichon homolog (Drosophila) Hs.294603 [show with all ESTs]Unigene Representative Sequence: BF1027137 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000395573 ENST00000216416(uc001xat.1 uc001xav.1) ENST00000557659
ENST00000553660 ENST00000557690 ENST00000554683 ENST00000556113
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CNIH (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CNIH
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: CNIH (NM_005776) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CNIH | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CNIH |
Additional cDNA sequence: AF070654.1 AF104398.1 AK074781.1 AK307074.1 AK311897.1 AY358635.1 BC103741.1 BX248284.1 20 DOTS entries: DT.452750 DT.91772094 DT.413217 DT.120761584 DT.100649822 DT.100649823 DT.95166619 DT.99986161 DT.120761558 DT.120761587 DT.100057579 DT.100860631 DT.120761563 DT.91772067 DT.91772093 DT.95166630 DT.95236613 DT.100773049 DT.92048963 DT.97854238 24/601 AceView cDNA sequences (see all 601): BM470229 BQ230824 BM742034 BE738950 CN481878 AI804120 BE784175 AI419055 F04288 BQ937490 H28462 BX457030 AI280992 BX426051 BU730445 F02558 AA316187 CR616723 AA297245 BF034555 AA258561 BE745778 CR596676 BX338125
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for CNIH About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 |
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| SP1: | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | - | | | | | | | | |
| SP3: | | | | | | | | | - | | | | - | | | | |
| SP4: | | | | | | | - | | - | | | | | | | | |
| SP5: | | | | | | | | | - | | - | | | | | |
ECgene alternative splicing isoforms for CNIH
|
Expression
for CNIH gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CNIH expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATATAAAAAT
About this image
See CNIH Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CNIH
SOURCE GeneReport for Unigene cluster: Hs.294603
UniProtKB/Swiss-Prot: CNIH_HUMAN, O95406Tissue specificity: Highly expressed in heart, liver, skeletal muscle, pancreas, adrenal medulla and cortex, thyroid,testis, spleen, appendix, peripheral blood lymphocytes and bone marrow. Lower expression found in brain, placenta,lung, kidney, ovary, small intestine, stomach, lymph node, thymus and fetal liver
SABiosciences Custom PCR Arrays for CNIH
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CNIH
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CNIH | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CNIH | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CNIH | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CNIH |
Orthologs
for CNIH gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for CNIH gene from 9/27 species (see all 27) About this table
ENSEMBL Gene Tree for CNIH (if available)
TreeFam Gene Tree for CNIH (if available) |
Paralogs
for CNIH gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CNIH gene
- CNIH32 CNIH42 CNIH22
3 SIMAP similar genes for CNIH using alignment to 8 protein entries: CNIH_HUMAN (see all proteins):CNIH2 CNIH3 CNIH4
CNIH for paralogs About GeneDecksing
|
Genomic Variants
for CNIH gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 14 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CNIH (54893647 - 54908149 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CNIH: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CNIH |
|
Disorders
/ Diseases
for CNIH gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CNIH for disorders About GeneDecksing
OMIM gene information: 611287
OMIM disorders: --
1  disease for CNIH: About MalaCardsthyroiditis
Export disorders for CNIH gene to outside databases
|
Publications
for CNIH gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CNIH gene integrated from 9 sources:
(articles sorted by number of sources associating them with CNIH) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The human homolog of Drosophila cornichon protein is differentially expressed in alloactivated T-cells. (PubMed id 10209299)1, 2, 3 Utku N.... Gullans S.R. (1999)
- Cornichon regulates transport and secretion of TGFalpha-related proteins in metazoan cells. (PubMed id 17607000)1, 2 Perez Castro C.... Derynck R. (2007)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
- Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2 Zhang Q.-H.... Chen Z. (2000)
- AMPA receptor modulation by cornichon-2 dictated by tr ansmembrane AMPA receptor regulatory protein isoform. (PubMed id 22211840)1 Gill M.B....Bredt D.S. (2012)
- Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1 Otsuki T....Isogai T. (2005)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
|
External Searches for CNIH gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CNIH gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CNIH gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CNIH gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CNIH | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for CNIH gene:
Search GeneIP for patents involving CNIH
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CNIH gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for CNIH | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CNIH | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CNIH | | | OriGene Protein Over-expression Lysate for CNIH | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CNIH | | OriGene 3'-UTR Clone for CNIH | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CNIH | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CNIH | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for CNIH | | OriGene Custom Protein Services for CNIH | | | OriGene Custom Immunoassay Development | | |
| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CNIH | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CNIH | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CNIH | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CNIH | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CNIH | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CNIH |
| |
 |  |  |  | |
| | | | Search Tocris compounds for CNIH |
| |  |  |  |  | | | | |
 |
 |
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 | | | CNIH Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CNIH |
|  |  |  | | | | Search ThermoFisher Antibodies for CNIH |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CNIH |
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