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CNGB3 Gene

protein-coding GIFtS: 59

GC08M087655

cyclic nucleotide gated channel beta 3
(Previous name: achromatopsia (rod monochromacy) 3 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: ACHM3)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
ACHM1 ^², ⁵
ACHM3 ^², ⁵
RMCH ^²
RMCH1 ^²

Descriptions
CNG channel beta-3 ^³
Cone photoreceptor cGMP-gated channel subunit beta ^³
Cyclic nucleotide-gated cation channel modulatory subunit ^², ³
Cyclic nucleotide-gated channel beta-3 ^³
achromatopsia (rod monochromacy) 3 ^¹
cone photoreceptor cGMP-gated cation channel beta-subunit ^²
cyclic nucleotide gated channel beta 3 ^²

External Ids
HGNC: 2153¹
Entrez Gene: 54714²
UniProtKB: Q9NQW8³
Ensembl: ENSG00000170289⁷

Search outside databases for aliases for CNGB3 gene

Previous GC identifers: GC08M086090 GC08M087318 GC08M087542 GC08M087541

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: CNGB3_HUMAN, Q9NQW8

Function: Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as

second messenger. This protein can be activated by cGMP which leads to an opening of the cation

channel and thereby causing a depolarization of rod photoreceptors. Induced a flickering channel

gating, weakened the outward rectification in the presence of extracellular calcium, increased

sensitivity for L-cis diltiazem and enhanced the cAMP efficiency of the channel when coexpressed

with CNGA3 (By similarity). Essential for the generation of light-evoked electrical responses in

the red-, green- and blue sensitive cones

Gene Wiki entry for CNGB3 (Cyclic_nucleotide_gated_channel_beta_3)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the CNGB3 gene

Entrez Gene cytogenetic band: 8q21-q22 Ensembl cytogenetic band: 8q21.3 HGNC cytogenetic band: 8q21.3

CNGB3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 8 GeneLoc Exon Structure

GeneLoc location for GC08M087655: (about GC identifiers)

Start:	87,655,277 bp from pter
End:	87,825,017 bp from pter
Size:	169,741 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000008.9 NT_008046.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: CNGB3_HUMAN, Q9NQW8 (See protein sequence)

Recommended Name: Cyclic nucleotide-gated cation channel beta-3

Size: 809 amino acids; 92250 Da

Subunit: Heterooligomeric complex with CNGA3

Subcellular location: Membrane; Multi-pass membrane protein

Secondary accessions: Q9NRE9

Alternative splicing: 2 isoforms: Q9NQW8-1 Q9NQW8-2

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_061971.3

ENSEMBL proteins:

ENSP00000316605

Human Recombinant Proteins

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Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001750	photoreceptor outer segment	IEA	--
GO:0016020	membrane	IEA	--
GO:0016021	integral to membrane	IEA	--

About this table

Antibodies for CNGB3:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for CNGB3

Assays for CNGB3:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q9NQW8

ProtoNet protein and cluster: Q9NQW8

1 Blocks protein family: IPB000595 Cyclic nucleotide-binding domain

UniProtKB/Swiss-Prot: CNGB3_HUMAN, Q9NQW8

Similarity: Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family

Similarity: Contains 1 cyclic nucleotide-binding domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CNGB3)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (CNGB3)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_019098

Applied Biosystems Silencer® siRNAs for CNGB3

Sigma-Aldrich siRNA and siRNA Panels for CNGB3

Sigma-Aldrich shRNA Panels and shRNA for CNGB3

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_019098
Myc/DDK tagged cDNA clone in CMV expression vector: NM_019098
untagged cDNA clone in CMV expression vector: NM_019098

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_019098

UniProtKB/Swiss-Prot: CNGB3_HUMAN, Q9NQW8

Function: Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as

second messenger. This protein can be activated by cGMP which leads to an opening of the cation

channel and thereby causing a depolarization of rod photoreceptors. Induced a flickering channel

gating, weakened the outward rectification in the presence of extracellular calcium, increased

sensitivity for L-cis diltiazem and enhanced the cAMP efficiency of the channel when coexpressed

with CNGA3 (By similarity). Essential for the generation of light-evoked electrical responses in

the red-, green- and blue sensitive cones

5 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0005216	ion channel activity	IEA	--
GO:0005223	intracellular cGMP activated cation channel activity	IEA	--
GO:0005515	protein binding	IEA	--
GO:0030553	cGMP binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

2 Sigma-Aldrich "Your Favorite Gene" Pathways for CNGB3 (Your Favorite Gene powered by Ingenuity)

Phototransduction Pathway
cAMP-mediated Signaling

GeneDecks CNGB3 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for CNGB3

4 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006811	ion transport	IEA	--
GO:0007165	signal transduction	NAS	10888875
GO:0007601	visual perception	TAS	10888875
GO:0050896	response to stimulus	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for CNGB3

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for CNGB3

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CNGB3)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (CNGB3)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_019098

Sigma-Aldrich siRNA and siRNA Panels for CNGB3

Sigma-Aldrich shRNA Panels and shRNA for CNGB3

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_019098

REFSEQ mRNAs for CNGB3 gene:

NM_019098.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_019098

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_019098
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_019098
                                 untagged cDNA clone in CMV expression vector: NM_019098

Additional cDNA sequence:

AF228520.1 AF272900.1 BC150601.1 DQ426865.1

2 DOTS entries:

DT.40263981 DT.426629

24/35 AceView cDNA sequences (see all 35 ):

AA064798 AF228520 BF725469 CA397799 AA702094 BF725470 AA069559 AA718978

AV726367 AA723276 NM_019098 H53424 AL713036 BI827605 BX104558 AA707769

BX118844 AA317961 AF272900 AA064967 AA069498 AA701157 AA704625 AA708280

highest scoring ESTs for CNGB3:

AA064756 AF272900 AL713036 AA012972 AA064759 AA064798 AA064814 AA064967 AA065114 AA069498

Unigene Cluster for CNGB3:

Cyclic nucleotide gated channel beta 3

Hs.154433 [show with all ESTs]

Unigene Representative Sequence: AF272900

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000320005

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

CNGB3 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for CNGB3

¹ / ² / ³

6 probe-sets matching CNGB3 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
55905_r_at²^{, 3}	U95-C	1	0.94	1.00	0.58	0.25	AA064756	0.80	1.00	0.91	1
55100_at²^{, 3}	U95-C	1	0.56	1.00	1.00	1.00	AI150392	0.60	1.00	0.82	1
222959_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AF272900	0.80	1.00	0.91	1
220304_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_019098	0.60	1.00	0.82	1
222959_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
220304_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.154433
UniProtKB/Swiss-Prot: CNGB3_HUMAN, Q9NQW8
Tissue specificity: Expressed specifically in the retina

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for CNGB3 gene from 5/8 species (see all 8 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	CNGB3¹	--	cyclic nucleotide gated channel beta 3	85.85(n) 79.1(a)	403554 NM_001003030.1 NP_001003030.1
chimpanzee (Pan troglodytes)	CNGB3¹	--	cyclic nucleotide gated channel beta 3	99.09(n) 99.13(a)	464272 XM_519846.2 XP_519846.2
cow (Bos taurus)	CNGB3¹	--	cyclic nucleotide gated channel beta 3	82.36(n) 77.14(a)	519225 XM_597439.3 XP_597439.3
rat (Rattus norvegicus)	Cngb3¹	--	cyclic nucleotide gated channel beta 3	79.07(n) 70.2(a)	500418 XM_575779.2 XP_575779.2
mouse (Mus musculus)	Cngb3^{1, 5}	4⁵	cyclic nucleotide gated channel beta 3^{1, 5}	79.24(n)¹ 69.65(a)¹	30952¹ NM_013927.2¹ NP_038955.1¹ AJ243572⁵ AK040140⁵ (see all 9)

About this table Species with no ortholog for CNGB3

ENSEMBL Gene Tree for CNGB3

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for CNGB3 gene

CNGB1²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/942 NCBI SNPs in CNGB3 are shown (see all 942 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 305)

AB	SNP ID	Valid	Chr 8 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs990193^1,2	A,C,F,H,O	87655267(-)	`GCTCTC/TGTCAC`	1	--	ng5¹		7	EU EA WA NA	560
	rs990192^1,2	A,C,F,H,O	87655509(-)	`TTTCGA/CCTGGC`	1	--	ut3¹		8	MN EU EA WA NA	740
	rs4961206^1,2	A,C,F,H	87735367(+)	`TTTTGG/TAGAAG`	1	T/P	mis¹ ese³		20	EU EA WA NS NA	1404
	rs7812496^1,2	A,C,F,H	87825007(+)	`TATTTA/CTGACT`	1	--	ut5¹		7	NA EU EA WA	552
	rs17683284^1,2	C,F,H	87655845(+)	`TGACTC/TTATCA`	1	--	ut3¹		15	NA EU EA WA	1400
	rs16916632^1,2	C,F,H	87749398(+)	`TAATTC/TGCTTT`	1	R/Q	mis¹		12	NA EU EA WA	1044
	rs6471482^1,2	C,F,H	87748419(+)	`ATAAAC/ACAGCA`	1	W/C	mis¹ ese³		12	NA EU EA WA	1058
	rs16915859^1,2	C,F,H	87656370(+)	`CCTGTA/GTCCTC`	1	--	ut3¹ ese³		7	NA EU EA WA	562
	rs10956955^1,2	A,C,F	87825567(+)	`TGTCAC/ATTTTG`	1	--	ng3¹		3	NA	142
	rs3735972^1,2	C,F,H	87657314(-)	`ACCTGA/GATGTA`	1	E/G	mis¹ ese³		12	EU EA WA NA	1202

About this table

HapMap Linkage Disequilibrium images for CNGB3 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 605080 disorders: 262300 248200

UniProtKB/Swiss-Prot: CNGB3_HUMAN, Q9NQW8

Defects in CNGB3 are the cause of Stargardt disease type 1 (STGD1) [MIM:248200]. STGD is

one of the most frequent causes of macular degeneration in childhood. It is characterized by

macular dystrophy with juvenile-onset, rapidly progressive course, alterations of the peripheral

retina, and subretinal deposition of lipofuscin-like material. STGD1 inheritance is autosomal

recessive

Defects in CNGB3 are the cause of achromatopsia type 3 (ACHM3) [MIM:262300]; also known as

Pingelapese blindness. ACHM3 is a congenital complete achromatopsia and is distinct from total

colorblindness mainly because of the consistent concurrence of severe myopia

1 Novoseek disease relationship for CNGB3 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
achromatopsia	97.74	21	15657609 (3), 16319819 (2), 17265047 (2), 12815043 (2) (see all 12)

About this table

GeneTests: CNGB3

Achromatopsia

Human Gene Mutation Database: CNGB3
Genetic Association Database: CNGB3
Human Genome Epidemiology Navigator: CNGB3 (1 document)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/31 PubMed articles for CNGB3 gene (see all 31 ):

CNGB3 mutations account for 50% of all cases with autosomal recessive achromatopsia. (PubMed id 15657609)^{1, 3, 4, 6} Kohl S....Wissinger B. (2005)
Mutations in the CNGB3 gene encoding the beta-subunit of the cone photoreceptor cGMP-gated channel are responsible for achromatopsia (ACHM3) linked to chromosome 8q21. (PubMed id 10958649)^{1, 2, 3, 4} Kohl S....Wissinger B. (2000)
Genetic basis of total colourblindness among the Pingelapese islanders. (PubMed id 10888875)^{2, 3, 4} Sundin O.H.... Maumenee I.H. (2000)
Cone cGMP-gated channel mutations and clinical findings in patients with achromatopsia, macular degeneration, and other hereditary cone diseases. (PubMed id 15712225)^{1, 3, 4} Nishiguchi K.M....Dryja T.P. (2005)
Achromatopsia caused by novel mutations in both CNGA3 and CNGB3. (PubMed id 14757870)^{1, 3, 4} Johnson S....Hunt D.M. (2004)
International Union of Pharmacology. LI. Nomenclature and structure-function relationships of cyclic nucleotide-regulated channels. (PubMed id 16382102)^{2, 3} Hofmann F....Kaupp U.B. (2005)
CNGB3 achromatopsia with progressive loss of residual cone function and impaired rod-mediated function. (PubMed id 17652762)^{1, 3} Khan N.W....Sieving P.A. (2007)
Functionally important calmodulin-binding sites in both NH2- and COOH-terminal regions of the cone photoreceptor cyclic nucleotide-gated channel CNGB3 subunit. (PubMed id 12730238)^{1, 3} Peng C....Varnum M.D. (2003)
Clinical and genetic features of Hungarian achromatopsia patients. (PubMed id 16319819)^{1, 3} Varsanyi B....Farkas A. (2005)
Achromatopsia: the CNGB3 p.T383fsX mutation results from a founder effect and is responsible for the visual phenotype in the original report of uniparental disomy 14. (PubMed id 17265047)^{1, 3} Wiszniewski W....Lupski J.R. (2007)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 54714	HGNC: 2153	AceView: CNGB3	Ensembl:ENSG00000170289	euGenes: HUgn54714
ECgene: CNGB3	H-InvDB: CNGB3

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for CNGB3	Genetics and Cytogenetics in Oncology and Haematology
GeneReviews	http://www.genetests.org/query?gene=CNGB3

Licensable Technologies for CNGB3
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for CNGB3:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for CNGB3-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for CNGB3		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for CNGB3		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Search Novus for antibodies for CNGB3

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CNGB3 Gene

protein-coding GIFtS: 59

Aliases &
Descriptions
for CNGB3

Summaries
for CNGB3

Genomic Location
for CNGB3

Proteins
for CNGB3

Protein Domains/
Families
for CNGB3

Gene Function
for CNGB3

Pathways & Interactions
for CNGB3

Drugs & Compounds
for CNGB3

Transcripts
for CNGB3

Expression
for CNGB3

Orthologs
for CNGB3

Paralogs
for CNGB3

SNPs/Variants
for CNGB3

Disorders & Mutations
for CNGB3

Medical News
for CNGB3

Publications
for CNGB3

Search for CNGB3

Genome Databases showing CNGB3

Other Databases showing CNGB3

Specialized Databases showing CNGB3

Licensable Technologies
for CNGB3

Services
for CNGB3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

CNGB3 Gene

protein-coding GIFtS: 59

Aliases & Descriptionsfor CNGB3

Summariesfor CNGB3

Genomic Locationfor CNGB3

Proteinsfor CNGB3

Protein Domains/Familiesfor CNGB3

Gene Functionfor CNGB3

Pathways & Interactionsfor CNGB3

Drugs & Compoundsfor CNGB3

Transcriptsfor CNGB3

Expression for CNGB3

Orthologsfor CNGB3

Paralogsfor CNGB3

SNPs/Variantsfor CNGB3

Disorders & Mutationsfor CNGB3

Medical Newsfor CNGB3

Publicationsfor CNGB3

Search for CNGB3

Genome Databases showing CNGB3

Other Databases showing CNGB3

Specialized Databases showing CNGB3

Licensable Technologiesfor CNGB3

Servicesfor CNGB3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for CNGB3

Summaries
for CNGB3

Genomic Location
for CNGB3

Proteins
for CNGB3

Protein Domains/
Families
for CNGB3

Gene Function
for CNGB3

Pathways & Interactions
for CNGB3

Drugs & Compounds
for CNGB3

Transcripts
for CNGB3

Expression
for CNGB3

Orthologs
for CNGB3

Paralogs
for CNGB3

SNPs/Variants
for CNGB3

Disorders & Mutations
for CNGB3

Medical News
for CNGB3

Publications
for CNGB3

Licensable Technologies
for CNGB3

Services
for CNGB3