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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CNGA4 Gene

protein-coding   GIFtS: 51
GCID: GC11P006255

Cyclic Nucleotide Gated Channel Alpha 4

(Previous name: cyclic nucleotide gated channel beta 2)
(Previous symbols: CNCA2, CNGB2)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Cyclic Nucleotide Gated Channel Alpha 41 2     CNG52
CNCA21 2     OCNC22
CNGB21 2     OCNCBETA2
Cyclic Nucleotide Gated Channel Beta 21 2     OCNCb2
CNG-42 3     Cyclic Nucleotide-Gated Cation Channel Alpha-42
CNG42 3     Cyclic Nucleotide-Gated Channel Alpha-43
CNG Channel Alpha-42 3     

External Ids:    HGNC: 21521   Entrez Gene: 12622   Ensembl: ENSG000001322597   OMIM: 6094725   UniProtKB: Q8IV773   

Export aliases for CNGA4 gene to outside databases

Previous GC identifers: GC00U990061 GC11U900397 GC11P006220 GC11P006212 GC11P005921


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CNGA4 Gene:
CNGA4 is a modulatory subunit of vertebrate cyclic nucleotide-gated membrane channels that transduce odorant
signals (Munger et al., 2001 (PubMed 11739959)).(supplied by OMIM, Mar 2008)

GeneCards Summary for CNGA4 Gene: 
CNGA4 (cyclic nucleotide gated channel alpha 4) is a protein-coding gene. Diseases associated with CNGA4 include cholera, and retinitis, and among its related super-pathways are Activation of cAMP-Dependent PKA and Cellular Effects of Sildenafil. GO annotations related to this gene include cAMP binding and ion channel activity. An important paralog of this gene is KCNH6.

UniProtKB/Swiss-Prot: CNGA4_HUMAN, Q8IV77
Function: Second messenger, cAMP, causes the opening of cation-selective cyclic nucleotide-gated (CNG) channels
and depolarization of the neuron (olfactory sensory neurons, OSNs). CNGA4 is the modulatory subunit of this
channel which is known to play a central role in the transduction of odorant signals and subsequent adaptation.
By accelerating the calcium-mediated negative feedback in olfactory signaling it allows rapid adaptation to odor
stimulation and extends its range of odor detection (By similarity)

Gene Wiki entry for CNGA4 (Cyclic nucleotide-gated channel alpha 4) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NT_009237.18  NC_018922.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CNGA4 gene promoter:
         GR   GR-beta   STAT3   GR-alpha   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCNGA4 promoter sequence
   Search SABiosciences Chromatin IP Primers for CNGA4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CNGA4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.4   Ensembl cytogenetic band:  11p15.4   HGNC cytogenetic band: 11p15.4

CNGA4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CNGA4 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P006255:  view genomic region     (about GC identifiers)

Start:
6,255,995 bp from pter      End:
6,265,707 bp from pter
Size:
9,713 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CNGA4_HUMAN, Q8IV77 (See protein sequence)
Recommended Name: Cyclic nucleotide-gated cation channel alpha-4  
Size: 575 amino acids; 65999 Da
Subunit: Heterotetramer composed of two subunits of CNGA2, one of CNGA4 and one of CNGB1b. The complex forms the
cyclic nucleotide-gated (CNG) channel of olfactory sensory neurons
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Sequence caution: Sequence=AAH40277.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=AK122736; Type=Frameshift; Positions=154;
Alternative splicing: 2 isoforms:  Q8IV77-1   Q8IV77-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CNGA4: NX_Q8IV77

Explore proteomics data for CNGA4 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8IV77

  • CNGA4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CNGA4 Protein Expression
    REFSEQ proteins: NP_001032406.1  
    ENSEMBL proteins: 
     ENSP00000433399   ENSP00000369268  

    Human Recombinant Protein Products for CNGA4: 
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    Novus Biologicals CNGA4 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005887integral to plasma membrane IBA--
    GO:0016020membrane ----
    GO:0016021integral to membrane ----

    CNGA4 for ontologies           About GeneDecksing



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    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CNG: Voltage-gated ion channels / Cyclic nucleotide-regulated channels

    IUPHAR Guide to PHARMACOLOGY protein family classification: CNGA4 
    Cyclic nucleotide-regulated channels

    5 InterPro protein domains:
     IPR018488 cNMP-bd_CS
     IPR018490 cNMP-bd-like
     IPR005821 Ion_trans_dom
     IPR000595 cNMP-bd_dom
     IPR014710 RmlC-like_jellyroll

    Graphical View of Domain Structure for InterPro Entry Q8IV77

    ProtoNet protein and cluster: Q8IV77

    1 Blocks protein domain: IPB000595 Cyclic nucleotide-binding domain

    UniProtKB/Swiss-Prot: CNGA4_HUMAN, Q8IV77
    Domain: The C-terminal coiled-coil domain mediates trimerization of CNGA subunits (By similarity)
    Similarity: Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family. CNGA4 subfamily
    Similarity: Contains 1 cyclic nucleotide-binding domain


    CNGA4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CNGA4_HUMAN, Q8IV77
    Function: Second messenger, cAMP, causes the opening of cation-selective cyclic nucleotide-gated (CNG) channels
    and depolarization of the neuron (olfactory sensory neurons, OSNs). CNGA4 is the modulatory subunit of this
    channel which is known to play a central role in the transduction of odorant signals and subsequent adaptation.
    By accelerating the calcium-mediated negative feedback in olfactory signaling it allows rapid adaptation to odor
    stimulation and extends its range of odor detection (By similarity)
    Enzyme regulation: Calcium-calmodulin exerts its inhibitory effect in cAMP sensitivity by binding to IQ-like motif
    of CNGA4 and preferably binds to the channel in the closed state. Inhibition by PIP3 of the CNG channel probably
    occurs via CGNA2 binding

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005216ion channel activity ----
    GO:0005222intracellular cAMP activated cation channel activity IBA--
    GO:0005223intracellular cGMP activated cation channel activity IBA--
    GO:0005249voltage-gated potassium channel activity IBA--
    GO:0030552cAMP binding IEA--
         
    CNGA4 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Cnga4):
     taste/olfaction 

    CNGA4 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for CNGA4 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CNGA4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CNGA4 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CNGA4 

    miRNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CNGA4


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CNGA4 About   (see all 8)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Activation of cAMP-Dependent PKA
    Activation of cAMP-Dependent PKA0.77
    PKA Signaling0.56
    cAMP Pathway0.77
    2Sweet Taste Signaling
    Cellular Effects of Sildenafil0.46
    Sperm Motility0.37
    3Olfactory transduction
    Olfactory transduction0.81
    4CREB Pathway
    Intracellular Calcium Signaling0.50
    5Nanog in Mammalian ESC Pluripotency
    eNOS Signaling0.48

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for CNGA4
        Potassium transporters- inward current

    5/9 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CNGA4 (see all 9)
        Cellular Effects of Sildenafil
    Cholera Infection
    PKA Signaling
    eNOS Signaling
    cAMP Pathway



    1         Kegg Pathway  (Kegg details for CNGA4):
        Olfactory transduction


    CNGA4 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CNGA4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    5/14 Interacting proteins for CNGA4 (ENSP000003692684) via UniProtKB, MINT, STRING, and/or I2D (see all 14)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ADCY3ENSP000002606004STRING: ENSP00000260600
    CALM1ENSP000003494674STRING: ENSP00000349467
    CALML3ENSP000003152994STRING: ENSP00000315299
    CALML5ENSP000003696894STRING: ENSP00000369689
    CALML6ENSP000003046434STRING: ENSP00000304643
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006811ion transport ----
    GO:0007603phototransduction, visible light IBA--
    GO:0007608sensory perception of smell IEA--
    GO:0042391regulation of membrane potential IBA--
    GO:0050896response to stimulus ----

    CNGA4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CNGA4

    10/18 HMDB Compounds for CNGA4 (see all 18)    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    Cyclic AMPCyclic AMP (see all 19)60-92-4--
    PIP3(16:0/16:0)PIP3(16:0/16:0) (see all 7)----
    PIP3(16:0/16:1(9Z))PIP3(16:0/16:1w7) (see all 11)----
    PIP3(16:0/18:1(11Z))Phosphatidylinositol Triphosphate(16:0/18:1w7) (see all 11)----
    PIP3(16:0/18:1(9Z))1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-myo-inositol-3',4',5'-trisphosphate) (see all 11)----
    PIP3(18:0/16:1(9Z))Phosphatidylinositol Triphosphate(18:0/16:1) (see all 11)----
    PIP3(18:0/18:1(11Z))Phosphatidylinositol Triphosphate(18:0/18:1w7) (see all 11)----
    PIP3(18:0/18:1(9Z))PIP3(36:1) (see all 11)----
    PIP3(18:1(11Z)/18:1(11Z))PIP3(18:1w7/18:1w7) (see all 11)----

    Search CenterWatch for drugs/clinical trials and news about CNGA4

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CNGA4 gene: 
    NM_001037329.3  

    Unigene Cluster for CNGA4:

    Cyclic nucleotide gated channel alpha 4
    Hs.434618  [show with all ESTs]
    Unigene Representative Sequence: NM_001037329
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000533426 ENST00000379936(uc001mco.3 uc010raa.2 uc001mcn.3)

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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CNGA4

    Additional mRNA sequence: 

    AK122736.1 AK302551.1 BC106935.2 BC106936.2 

    2 DOTS entries:

    DT.101960960  DT.95201420 

    6 AceView cDNA sequences:

    BC040277 BU158634 BQ429429 AK122736 BI830763 BM473083 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CNGA4 expression in normal human tissues (normalized intensities)      CNGA4 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGGAGAAAG
    CNGA4 Expression
    About this image


    CNGA4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Epithelium (Respiratory System)    fully expand to see all 2 entries
             bronchial epithelial cells   
     
     Gut Tube (Gastrointestinal Tract)
             Definitive endoderm-like cells ( A scalable, suspension protocol for derivation of...
     
     Inner Cell Mass (Early Embryonic Tissues)
             Line H9 (WA09)

    See CNGA4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CNGA4

    SOURCE GeneReport for Unigene cluster: Hs.434618
        SABiosciences Expression via Pathway-Focused PCR Array including CNGA4: 
              Hypertension in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CNGA4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for CNGA4 gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cnga41 , 5 cyclic nucleotide gated channel alpha 41, 5 88.87(n)1
    93.22(a)1
      7 (55.85 cM)5
    2336491  NM_001033317.31  NP_001028489.11 
     1054045685 
    chicken
    (Gallus gallus)
    Aves CNGA41 cyclic nucleotide gated channel alpha 4 67.86(n)
    63.09(a)
      430630  XM_428185.3  XP_428185.3 
    lizard
    (Anolis carolinensis)
    Reptilia CNGA46
    Uncharacterized protein
    56(a)
    1 ↔ 1
    GL344039.1(8066-29620)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5681231 cyclic nucleotide-gated cation channel alpha-4-like 62.24(n)
    60.72(a)
      568123  XM_002663396.2  XP_002663442.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta Cng6
    Cyclic-nucleotide-gated ion channel protein
    30(a)
    1 → many
    2R(12130650-12147000)
    worm
    (Caenorhabditis elegans)
    Secernentea tax-46
    cng-16
    (see all 5)
    Protein CNG-1, isoform b
    (see all 5)
    31(a)
    25(a)
    (see all 5)
    1 ↔ many
    possible ortholog
    (see all 5)
    III(9181550-9185649)
    V(15025740-15030250)


    ENSEMBL Gene Tree for CNGA4 (if available)
    TreeFam Gene Tree for CNGA4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CNGA4 gene
    KCNH62  KCNH32  KCNH52  HCN32  HCN42  KCNH42  HCN22  CNGA22  
    CNGA12  HCN12  KCNH22  KCNH72  CNGB12  CNGA32  CNGB32  KCNH82  
    KCNH12  
    5 SIMAP similar genes for CNGA4 using alignment to 2 protein entries:     CNGA4_HUMAN (see all proteins):
    CNGA1    CNGA3    CNGA2    CNGB1    CNGB3

    CNGA4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/219 SNPs in CNGA4 are shown (see all 219)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1926024191,2
    --6258341(+) AACACA/GCATTC 1 -- us2k10--------
    rs1422830451,2
    --6258479(+) TGCCAC/TAACAT 1 -- us2k10--------
    rs1845434611,2
    --6258555(+) CTAGAA/GGAAAA 1 -- us2k10--------
    rs1902408791,2
    --6258638(+) CATCCA/GGTGAG 1 -- us2k10--------
    rs575284111,2
    C--6258689(+) CGGGAG/ACCACT 1 -- us2k13Minor allele frequency- A:0.14NA EA 242
    rs113128811,2
    C--6258785(+) CCAAG-/AAAAAA 1 -- us2k1 trp32Minor allele frequency- A:0.25NA CSA 4
    rs1140179981,2
    C--6258825(+) GAGGAA/GCTTAT 1 -- us2k10--------
    rs728922041,2
    --6258841(+) ACACTA/TAAAAG 1 -- us2k10--------
    rs1388498501,2
    --6258974(+) GGGAAA/GAGAGA 1 -- us2k10--------
    rs1428180311,2
    --6259092(+) TATTGC/TCGTTG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CNGA4 (6255995 - 6265707 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for CNGA4: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CNGA4
    DNA2.0 Custom Variant and Variant Library Synthesis for CNGA4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 609472    OMIM disorders: --

    4 diseases for CNGA4:    About MalaCards
    cholera    retinitis    hypertension    neuronitis


    CNGA4 for disorders           About GeneDecksing


    Export disorders for CNGA4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CNGA4 gene, integrated from 9 sources (see all 11):
    (articles sorted by number of sources associating them with CNGA4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. International Union of Pharmacology. LI. Nomenclature and structure-function relationships of cyclic nucleotide-regulated channels. (PubMed id 16382102)1, 3 Hofmann F....Kaupp U.B. (2005)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. Nomenclature for ion channel subunits. (PubMed id 11764791)1, 3 Bradley J....Reed R. (2001)
    4. Interplay between PIP3 and calmodulin regulation of olfactory cyclic nucleotide-gated channels. (PubMed id 17032767)2 Brady J.D....Brown R.L. (2006)
    5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    6. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)2 Taylor T.D....Sakaki Y. (2006)
    7. Calmodulin permanently associates with rat olfactory CNG channels under native conditions. (PubMed id 15195096)2 Bradley J.... Frings S. (2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    9. Importance of the CNGA4 channel gene for odor discrimination and adaptation in behaving mice. (PubMed id 12649326)1 Kelliher K.R....Zufall F. (2003)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1262 HGNC: 2152 AceView: CNGA4 Ensembl:ENSG00000132259 euGenes: HUgn1262
    ECgene: CNGA4 Kegg: 1262 H-InvDB: CNGA4

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CNGA4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CNGA4 gene:
    Search GeneIP for patents involving CNGA4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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