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CNGA4 Gene

protein-coding   GIFtS: 50
GCID: GC11P006255

Cyclic Nucleotide Gated Channel Alpha 4

(Previous name: cyclic nucleotide gated channel beta 2)
(Previous symbols: CNCA2, CNGB2)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cyclic Nucleotide Gated Channel Alpha 41 2     CNG52
CNCA21 2     OCNC22
CNGB21 2     OCNCBETA2
Cyclic Nucleotide Gated Channel Beta 21 2     OCNCb2
CNG-42 3     Cyclic Nucleotide-Gated Cation Channel Alpha-42
CNG42 3     Cyclic Nucleotide-Gated Channel Alpha-43
CNG Channel Alpha-42 3     

External Ids:    HGNC: 21521   Entrez Gene: 12622   Ensembl: ENSG000001322597   OMIM: 6094725   UniProtKB: Q8IV773   

Export aliases for CNGA4 gene to outside databases

Previous GC identifers: GC00U990061 GC11U900397 GC11P006220 GC11P006212 GC11P005921


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CNGA4 Gene:
CNGA4 is a modulatory subunit of vertebrate cyclic nucleotide-gated membrane channels that transduce odorant
signals (Munger et al., 2001 (PubMed 11739959)).(supplied by OMIM, Mar 2008)

GeneCards Summary for CNGA4 Gene:
CNGA4 (cyclic nucleotide gated channel alpha 4) is a protein-coding gene. Diseases associated with CNGA4 include cholera, and retinitis. GO annotations related to this gene include cGMP binding and voltage-gated potassium channel activity. An important paralog of this gene is KCNH6.

UniProtKB/Swiss-Prot: CNGA4_HUMAN, Q8IV77
Function: Second messenger, cAMP, causes the opening of cation-selective cyclic nucleotide-gated (CNG) channels
and depolarization of the neuron (olfactory sensory neurons, OSNs). CNGA4 is the modulatory subunit of this
channel which is known to play a central role in the transduction of odorant signals and subsequent adaptation.
By accelerating the calcium-mediated negative feedback in olfactory signaling it allows rapid adaptation to odor
stimulation and extends its range of odor detection (By similarity)

Gene Wiki entry for CNGA4 (Cyclic nucleotide-gated channel alpha 4) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000011.10  NT_009237.19  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CNGA4 gene promoter:
         GR   GR-beta   STAT3   GR-alpha   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCNGA4 promoter sequence
   Search Chromatin IP Primers for CNGA4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CNGA4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.4   Ensembl cytogenetic band:  11p15.4   HGNC cytogenetic band: 11p15.4

CNGA4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CNGA4 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P006255:  view genomic region     (about GC identifiers)

Start:
6,255,995 bp from pter      End:
6,265,707 bp from pter
Size:
9,713 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CNGA4_HUMAN, Q8IV77 (See protein sequence)
Recommended Name: Cyclic nucleotide-gated cation channel alpha-4  
Size: 575 amino acids; 65999 Da
Subunit: Heterotetramer composed of two subunits of CNGA2, one of CNGA4 and one of CNGB1b. The complex forms the
cyclic nucleotide-gated (CNG) channel of olfactory sensory neurons
Sequence caution: Sequence=AAH40277.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=AK122736; Type=Frameshift; Positions=154;
Alternative splicing: 2 isoforms:  Q8IV77-1   Q8IV77-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CNGA4: NX_Q8IV77

Explore proteomics data for CNGA4 at MOPED


See CNGA4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_001032406.1  
ENSEMBL proteins: 
 ENSP00000433399   ENSP00000369268  

CNGA4 Human Recombinant Protein Products:

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Novus Biologicals CNGA4 Protein
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Browse Proteins at Cloud-Clone Corp.

CNGA4 Antibody Products:

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Abcam antibodies for CNGA4
Browse Antibodies at Cloud-Clone Corp.
Search ThermoFisher Antibodies for CNGA4
LSBio Antibodies in human, mouse, rat for CNGA4

CNGA4 Assay Products:

Browse Kits and Assays available from EMD Millipore
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GenScript Custom Assay Services for CNGA4
Browse Enzo Life Sciences for kits & assays
Browse ELISAs at Cloud-Clone Corp.
Browse CLIAs at Cloud-Clone Corp.


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
CNG: Voltage-gated ion channels / Cyclic nucleotide-regulated channels

IUPHAR Guide to PHARMACOLOGY protein family classification: CNGA4
Cyclic nucleotide-regulated channels

5 InterPro protein domains:
 IPR018488 cNMP-bd_CS
 IPR018490 cNMP-bd-like
 IPR005821 Ion_trans_dom
 IPR000595 cNMP-bd_dom
 IPR014710 RmlC-like_jellyroll

Graphical View of Domain Structure for InterPro Entry Q8IV77

ProtoNet protein and cluster: Q8IV77

1 Blocks protein domain: IPB000595 Cyclic nucleotide-binding domain

UniProtKB/Swiss-Prot: CNGA4_HUMAN, Q8IV77
Domain: The C-terminal coiled-coil domain mediates trimerization of CNGA subunits (By similarity)
Similarity: Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family. CNGA4 subfamily
Similarity: Contains 1 cyclic nucleotide-binding domain


CNGA4 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: CNGA4_HUMAN, Q8IV77
Function: Second messenger, cAMP, causes the opening of cation-selective cyclic nucleotide-gated (CNG) channels
and depolarization of the neuron (olfactory sensory neurons, OSNs). CNGA4 is the modulatory subunit of this
channel which is known to play a central role in the transduction of odorant signals and subsequent adaptation.
By accelerating the calcium-mediated negative feedback in olfactory signaling it allows rapid adaptation to odor
stimulation and extends its range of odor detection (By similarity)
Enzyme regulation: Calcium-calmodulin exerts its inhibitory effect in cAMP sensitivity by binding to IQ-like motif
of CNGA4 and preferably binds to the channel in the closed state. Inhibition by PIP3 of the CNG channel probably
occurs via CGNA2 binding

     Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005216ion channel activity ----
GO:0005222intracellular cAMP activated cation channel activity IBA--
GO:0005223intracellular cGMP activated cation channel activity IBA--
GO:0005249voltage-gated potassium channel activity IBA--
GO:0030552cAMP binding IEA--
     
CNGA4 for ontologies           About GeneDecksing


Phenotypes:
     1 MGI mutant phenotype (inferred from 1 allele(MGI details for Cnga4):
 taste/olfaction 

CNGA4 for phenotypes           About GeneDecksing

Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CNGA4
   inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CNGA4

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CNGA4
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CNGA4

miRNA
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Search for qRT-PCR Assays for microRNAs that regulate CNGA4
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
Products:
    
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Predesigned siRNA for gene silencing in human, mouse, rat CNGA4

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for CNGA4

Clone
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OriGene clones in human, mouse for CNGA4 (see all 6)
OriGene ORF clones in mouse, rat for CNGA4
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: CNGA4 (NM_001037329)
Sino Biological Human cDNA Clone for CNGA4
DNA2.0 Custom Codon Optimized Gene Synthesis Service for CNGA4
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CNGA4

Cell Line
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Browse ESI BIO Cell Lines and PureStem Progenitors for CNGA4 
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CNGA4


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
CNGA4_HUMAN, Q8IV77: Membrane; Multi-pass membrane protein (Potential)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
plasma membrane3
cytosol1
endoplasmic reticulum1
mitochondrion1
nucleus1
peroxisome1

Gene Ontology (GO): 2 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005887integral component of plasma membrane IBA--
GO:0016020membrane ----

CNGA4 for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for CNGA4 About   (see all 8)  
See pathways by source

SuperPathContained pathways About
1Activation of cAMP-Dependent PKA
Activation of cAMP-Dependent PKA0.77
PKA Signaling0.56
cAMP Pathway0.77
2Sweet Taste Signaling
Cellular Effects of Sildenafil0.46
Sperm Motility0.37
3Olfactory Signaling Pathway
Olfactory transduction0.82
4CREB Pathway
Intracellular Calcium Signaling0.50
5Nanog in Mammalian ESC Pluripotency
eNOS Signaling0.48

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways

Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CNGA4 (see all 9)
    Cellular Effects of Sildenafil
Cholera Infection
PKA Signaling
eNOS Signaling
cAMP Pathway



1 Kegg Pathway  (Kegg details for CNGA4):
    Olfactory transduction


CNGA4 for pathways           About GeneDecksing

    Pathway & Disease-focused RT2 Profiler PCR Array including CNGA4: 
          Hypertension in human mouse rat

Interactions:

    Search GeneGlobe Interaction Network for CNGA4

STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

Selected Interacting proteins for CNGA4 (ENSP000003692684) via UniProtKB, MINT, STRING, and/or I2D (see all 15)
InteractantInteraction Details
GeneCardExternal ID(s)
ADCY3ENSP000002606004STRING: ENSP00000260600
CALM1ENSP000003494674STRING: ENSP00000349467
CALML3ENSP000003152994STRING: ENSP00000315299
CALML5ENSP000003696894STRING: ENSP00000369689
CALML6ENSP000003046434STRING: ENSP00000304643
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Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006811ion transport ----
GO:0007603phototransduction, visible light IBA--
GO:0007608sensory perception of smell IEA--
GO:0042391regulation of membrane potential IBA--
GO:0055085transmembrane transport ----

CNGA4 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for CNGA4

Selected HMDB Compounds for CNGA4 (see all 18)    About this table
CompoundSynonyms CAS #PubMed Ids
CalciumCa (see all 2)7440-70-2--
Cyclic AMPCyclic AMP (see all 19)60-92-4--
PIP3(16:0/16:0)PIP3(16:0/16:0) (see all 7)----
PIP3(16:0/16:1(9Z))PIP3(16:0/16:1w7) (see all 11)----
PIP3(16:0/18:1(11Z))Phosphatidylinositol Triphosphate(16:0/18:1w7) (see all 11)----
PIP3(16:0/18:1(9Z))1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-myo-inositol-3',4',5'-trisphosphate) (see all 11)----
PIP3(18:0/16:1(9Z))Phosphatidylinositol Triphosphate(18:0/16:1) (see all 11)----
PIP3(18:0/18:1(11Z))Phosphatidylinositol Triphosphate(18:0/18:1w7) (see all 11)----
PIP3(18:0/18:1(9Z))PIP3(36:1) (see all 11)----
PIP3(18:1(11Z)/18:1(11Z))PIP3(18:1w7/18:1w7) (see all 11)----



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for CNGA4 gene: 
NM_001037329.3  

Unigene Cluster for CNGA4:

Cyclic nucleotide gated channel alpha 4
Hs.434618  [show with all ESTs]
Unigene Representative Sequence: NM_001037329
2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000533426 ENST00000379936(uc001mco.3 uc010raa.2 uc001mcn.3)

miRNA
Products:
     
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Search for qRT-PCR Assays for microRNAs that regulate CNGA4
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for CNGA4
Predesigned siRNA for gene silencing in human, mouse, rat CNGA4
Clone
Products:
     
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OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: CNGA4 (NM_001037329)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for CNGA4
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CNGA4
Primer
Products:
    
OriGene qSTAR qPCR primer pairs in human, mouse for CNGA4
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CNGA4
  QuantiTect SYBR Green Assays in human, mouse, rat CNGA4
  QuantiFast Probe-based Assays in human, mouse, rat CNGA4

Additional mRNA sequence: 

AK122736.1 AK302551.1 BC106935.2 BC106936.2 

2 DOTS entries:

DT.101960960  DT.95201420 

6 AceView cDNA sequences:

BC040277 BU158634 BQ429429 AK122736 BI830763 BM473083 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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CNGA4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GAGGAGAAAG
CNGA4 Expression
About this image

CNGA4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

CNGA4 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.434618
    Pathway & Disease-focused RT2 Profiler PCR Array including CNGA4: 
          Hypertension in human mouse rat

Primer
Products:
OriGene qSTAR qPCR primer pairs in human, mouse for CNGA4
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CNGA4
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CNGA4

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for CNGA4 gene from Selected species (see all 14)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Cnga41 , 5 cyclic nucleotide gated channel alpha 41, 5 88.87(n)1
93.22(a)1
  7 (55.85 cM)5
2336491  NM_001033317.31  NP_001028489.11 
 1054045685 
chicken
(Gallus gallus)
Aves CNGA41 cyclic nucleotide gated channel alpha 4 66.94(n)
61.07(a)
  430630  XM_428185.4  XP_428185.4 
lizard
(Anolis carolinensis)
Reptilia CNGA46
cyclic nucleotide gated channel alpha 4
55(a)
1 ↔ 1
GL344039.1(8066-29620)
tropical clawed frog
(Xenopus tropicalis)
Amphibia cnga41 cyclic nucleotide gated channel alpha 4 67.05(n)
66.15(a)
  100489546  XM_002942550.2  XP_002942596.2 
zebrafish
(Danio rerio)
Actinopterygii cnga41 cyclic nucleotide gated channel alpha 4 62.75(n)
61.25(a)
  568123  XM_002663396.3  XP_002663442.3 
fruit fly
(Drosophila melanogaster)
Insecta Cng6
Cyclic-nucleotide-gated ion channel protein
30(a)
1 → many
2R(12130650-12147000)
worm
(Caenorhabditis elegans)
Secernentea tax-46
che-66
(see all 5)
Protein CHE-6
(see all 5)
31(a)
25(a)
(see all 5)
many ↔ many
many ↔ many
(see all 5)
III(9181550-9185649) WBGene00006526
IV(2104056-2111605) WBGene00000487


ENSEMBL Gene Tree for CNGA4 (if available)
TreeFam Gene Tree for CNGA4 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for CNGA4 gene
KCNH62  KCNH32  KCNH52  HCN32  HCN42  KCNH42  HCN22  CNGA12  
CNGA22  HCN12  KCNH22  KCNH72  CNGB12  CNGA32  CNGB32  KCNH82  
KCNH12  
5 SIMAP similar genes for CNGA4 using alignment to 2 protein entries:     CNGA4_HUMAN (see all proteins):
CNGA1    CNGA3    CNGA2    CNGB1    CNGB3

CNGA4 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for CNGA4 (see all 219)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 11 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1926024191,2
--6258341(+) AACACA/GCATTC 1 -- us2k10--------
rs1422830451,2
--6258479(+) TGCCAC/TAACAT 1 -- us2k10--------
rs1845434611,2
--6258555(+) CTAGAA/GGAAAA 1 -- us2k10--------
rs1902408791,2
--6258638(+) CATCCA/GGTGAG 1 -- us2k10--------
rs575284111,2
C--6258689(+) CGGGAG/ACCACT 1 -- us2k13Minor allele frequency- A:0.14NA EA 242
rs113128811,2
C--6258785(+) CCAAG-/AAAAAA 1 -- us2k1 trp32Minor allele frequency- A:0.25NA CSA 4
rs1140179981,2
C--6258825(+) GAGGAA/GCTTAT 1 -- us2k10--------
rs728922041,2
--6258841(+) ACACTA/TAAAAG 1 -- us2k10--------
rs1388498501,2
--6258974(+) GGGAAA/GAGAGA 1 -- us2k10--------
rs1428180311,2
--6259092(+) TATTGC/TCGTTG 1 -- us2k10--------

HapMap Linkage Disequilibrium report for CNGA4 (6255995 - 6265707 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for CNGA4: --
Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing CNGA4
DNA2.0 Custom Variant and Variant Library Synthesis for CNGA4

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 609472    OMIM disorders: --

4 diseases for CNGA4:    
About MalaCards
cholera    retinitis    hypertension    neuronitis


CNGA4 for disorders           About GeneDecksing


Export disorders for CNGA4 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for CNGA4 gene, integrated from 10 sources (see all 11):
(articles sorted by number of sources associating them with CNGA4)
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  1. International Union of Pharmacology. LI. Nomenclature and structure-function relationships of cyclic nucleotide-regulated channels. (PubMed id 16382102)1, 3 Hofmann F....Kaupp U.B. (Pharmacol. Rev. 2005)
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
  3. Nomenclature for ion channel subunits. (PubMed id 11764791)1, 3 Bradley J....Reed R. (Science 2001)
  4. Interplay between PIP3 and calmodulin regulation of olfactory cyclic nucleotide-gated channels. (PubMed id 17032767)2 Brady J.D....Brown R.L. (Proc. Natl. Acad. Sci. U.S.A. 2006)
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
  6. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)2 Taylor T.D....Sakaki Y. (Nature 2006)
  7. Calmodulin permanently associates with rat olfactory CNG channels under native conditions. (PubMed id 15195096)2 Bradley J.... Frings S. (Nat. Neurosci. 2004)
  8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  9. Importance of the CNGA4 channel gene for odor discrimination and adaptation in behaving mice. (PubMed id 12649326)1 Kelliher K.R....Zufall F. (Proc. Natl. Acad. Sci. U.S.A. 2003)
  10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 1262 HGNC: 2152 AceView: CNGA4 Ensembl:ENSG00000132259 euGenes: HUgn1262
ECgene: CNGA4 Kegg: 1262 H-InvDB: CNGA4

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for CNGA4 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for CNGA4 gene:
Search GeneIP for patents involving CNGA4

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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