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Aliases for CNGA4 Gene

Aliases for CNGA4 Gene

  • Cyclic Nucleotide Gated Channel Alpha 4 2 3 5
  • Cyclic Nucleotide Gated Channel Beta 2 2 3
  • CNG Channel Alpha-4 3 4
  • CNG-4 3 4
  • CNG4 3 4
  • Cyclic Nucleotide-Gated Cation Channel Alpha-4 3
  • Cyclic Nucleotide-Gated Channel Alpha-4 4
  • OCNCBETA 3
  • OCNC2 3
  • OCNCb 3
  • CNCA2 3
  • CNGB2 3
  • CNG5 3

External Ids for CNGA4 Gene

Previous HGNC Symbols for CNGA4 Gene

  • CNCA2
  • CNGB2

Previous GeneCards Identifiers for CNGA4 Gene

  • GC00U990061
  • GC11U900397
  • GC11P006220
  • GC11P006212
  • GC11P005921

Summaries for CNGA4 Gene

Entrez Gene Summary for CNGA4 Gene

  • CNGA4 is a modulatory subunit of vertebrate cyclic nucleotide-gated membrane channels that transduce odorant signals (Munger et al., 2001 [PubMed 11739959]).[supplied by OMIM, Mar 2008]

GeneCards Summary for CNGA4 Gene

CNGA4 (Cyclic Nucleotide Gated Channel Alpha 4) is a Protein Coding gene. Among its related pathways are Nanog in Mammalian ESC Pluripotency and Organelle biogenesis and maintenance. GO annotations related to this gene include ion channel activity and cAMP binding. An important paralog of this gene is CNGA3.

UniProtKB/Swiss-Prot for CNGA4 Gene

  • Second messenger, cAMP, causes the opening of cation-selective cyclic nucleotide-gated (CNG) channels and depolarization of the neuron (olfactory sensory neurons, OSNs). CNGA4 is the modulatory subunit of this channel which is known to play a central role in the transduction of odorant signals and subsequent adaptation. By accelerating the calcium-mediated negative feedback in olfactory signaling it allows rapid adaptation to odor stimulation and extends its range of odor detection (By similarity).

Gene Wiki entry for CNGA4 Gene

Additional gene information for CNGA4 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CNGA4 Gene

Genomics for CNGA4 Gene

Regulatory Elements for CNGA4 Gene

Enhancers for CNGA4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11H006233 1.1 ENCODE 14.9 +0.1 85 2 HDGF PKNOX1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 FAM160A2 RRP8 CNGA4 APBB1 ENSG00000254641 CCKBR TRIM34 GC11M006236
GH11H006258 1.3 FANTOM5 Ensembl ENCODE 6.5 +25.1 25069 2 CTCF MXI1 SUZ12 CHD7 ZFHX2 POLR2A ZNF366 ZNF600 PRDM10 EGR2 CCKBR APBB1 CNGA4 TRIM3 DCHS1 GC11M006274
GH11H006200 1.6 FANTOM5 Ensembl ENCODE dbSUPER 4.8 -33.4 -33431 2 PKNOX1 HLF CEBPB MAX ELF1 CEBPG REST GABPA POLR2A IKZF1 FAM160A2 TRIM5 CNGA4 TPP1 ENSG00000267940 GC11M006197
GH11H006185 0.2 Ensembl 6.3 -49.2 -49165 0 CNGA4 ENSG00000254444 GC11M006198
GH11H006240 0.3 FANTOM5 0.4 +6.3 6298 0 TPP1 FAM160A2 CNGA4 GC11M006236
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CNGA4 on UCSC Golden Path with GeneCards custom track

Promoters for CNGA4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000036265 135 1801 HDGF PKNOX1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143

Genomic Location for CNGA4 Gene

Chromosome:
11
Start:
6,234,765 bp from pter
End:
6,245,924 bp from pter
Size:
11,160 bases
Orientation:
Plus strand

Genomic View for CNGA4 Gene

Genes around CNGA4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CNGA4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CNGA4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CNGA4 Gene

Proteins for CNGA4 Gene

  • Protein details for CNGA4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IV77-CNGA4_HUMAN
    Recommended name:
    Cyclic nucleotide-gated cation channel alpha-4
    Protein Accession:
    Q8IV77

    Protein attributes for CNGA4 Gene

    Size:
    575 amino acids
    Molecular mass:
    65999 Da
    Quaternary structure:
    • Heterotetramer composed of two subunits of CNGA2, one of CNGA4 and one of CNGB1b. The complex forms the cyclic nucleotide-gated (CNG) channel of olfactory sensory neurons.
    SequenceCaution:
    • Sequence=AAH40277.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AK122736; Type=Frameshift; Positions=154; Evidence={ECO:0000305};

    Alternative splice isoforms for CNGA4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CNGA4 Gene

Post-translational modifications for CNGA4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CNGA4 Gene

No data available for DME Specific Peptides for CNGA4 Gene

Domains & Families for CNGA4 Gene

Gene Families for CNGA4 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Voltage-gated ion channels

Graphical View of Domain Structure for InterPro Entry

Q8IV77

UniProtKB/Swiss-Prot:

CNGA4_HUMAN :
  • The C-terminal coiled-coil domain mediates trimerization of CNGA subunits.
  • Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family. CNGA4 subfamily.
Domain:
  • The C-terminal coiled-coil domain mediates trimerization of CNGA subunits.
Family:
  • Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family. CNGA4 subfamily.
genes like me logo Genes that share domains with CNGA4: view

Function for CNGA4 Gene

Molecular function for CNGA4 Gene

UniProtKB/Swiss-Prot EnzymeRegulation:
Calcium-calmodulin exerts its inhibitory effect in cAMP sensitivity by binding to IQ-like motif of CNGA4 and preferably binds to the channel in the closed state. Inhibition by PIP3 of the CNG channel probably occurs via CGNA2 binding.
UniProtKB/Swiss-Prot Function:
Second messenger, cAMP, causes the opening of cation-selective cyclic nucleotide-gated (CNG) channels and depolarization of the neuron (olfactory sensory neurons, OSNs). CNGA4 is the modulatory subunit of this channel which is known to play a central role in the transduction of odorant signals and subsequent adaptation. By accelerating the calcium-mediated negative feedback in olfactory signaling it allows rapid adaptation to odor stimulation and extends its range of odor detection (By similarity).

Gene Ontology (GO) - Molecular Function for CNGA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0005216 ion channel activity IEA --
GO:0005249 voltage-gated potassium channel activity IBA --
GO:0030552 cAMP binding IEA --
genes like me logo Genes that share ontologies with CNGA4: view
genes like me logo Genes that share phenotypes with CNGA4: view

Animal Models for CNGA4 Gene

MGI Knock Outs for CNGA4:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for CNGA4
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CNGA4 Gene

Localization for CNGA4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CNGA4 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CNGA4 gene
Compartment Confidence
plasma membrane 5
golgi apparatus 4
mitochondrion 1
peroxisome 1
nucleus 1
endoplasmic reticulum 1
cytosol 1

Gene Ontology (GO) - Cellular Components for CNGA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030660 Golgi-associated vesicle membrane TAS --
genes like me logo Genes that share ontologies with CNGA4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CNGA4 Gene

Pathways & Interactions for CNGA4 Gene

genes like me logo Genes that share pathways with CNGA4: view

Gene Ontology (GO) - Biological Process for CNGA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006811 ion transport IEA --
GO:0007608 sensory perception of smell IEA --
GO:0034220 ion transmembrane transport IEA --
GO:0042391 regulation of membrane potential IBA --
genes like me logo Genes that share ontologies with CNGA4: view

No data available for SIGNOR curated interactions for CNGA4 Gene

Drugs & Compounds for CNGA4 Gene

(2) Drugs for CNGA4 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
cyclic amp Experimental Pharma 0
calcium Nutra 0

(16) Additional Compounds for CNGA4 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
PIP3(16:0/16:0)
  • 1,2-Dihexadecanoyl-rac-glycero-3-phospho-(1'-myo-inositol-3',4',5'-trisphosphate)
  • 1,2-Dipalmitoyl-rac-glycero-3-phosphoinositol-trisphosphate
  • Phosphatidylinositol Triphosphate(16:0/16:0)
  • Phosphatidylinositol Triphosphate(32:0)
  • PIP3(16:0/16:0)
PIP3(16:0/16:1(9Z))
  • 1-Hexadecanoyl-2-(9Z-hexadecenoyl)-sn-glycero-3-phospho-(1'-myo-inositol-3',4',5'-trisphosphate)
  • 1-Palmitoyl-2-palmitoleoyl-sn-glycero-3-phosphoinositol-trisphosphate
  • Phosphatidylinositol Triphosphate(16:0/16:1)
  • Phosphatidylinositol Triphosphate(16:0/16:1n7)
  • Phosphatidylinositol Triphosphate(16:0/16:1w7)
PIP3(16:0/18:1(11Z))
  • 1-Hexadecanoyl-2-(11Z-octadecenoyl)-sn-glycero-3-phospho-(1'-myo-inositol-3',4',5'-trisphosphate)
  • 1-Palmitoyl-2-vaccenoyl-sn-glycero-3-phosphoinositol-trisphosphate
  • Phosphatidylinositol Triphosphate(16:0/18:1)
  • Phosphatidylinositol Triphosphate(16:0/18:1n7)
  • Phosphatidylinositol Triphosphate(16:0/18:1w7)
PIP3(16:0/18:1(9Z))
  • 1-Hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-myo-inositol-3',4',5'-trisphosphate)
  • 1-Palmitoyl-2-oleoyl-sn-glycero-3-phosphoinositol-trisphosphate
  • Phosphatidylinositol Triphosphate(16:0/18:1)
  • Phosphatidylinositol Triphosphate(16:0/18:1n9)
  • Phosphatidylinositol Triphosphate(16:0/18:1w9)
PIP3(18:0/16:1(9Z))
  • 1-Octadecanoyl-2-(9Z-hexadecenoyl)-sn-glycero-3-phospho-(1'-myo-inositol-3',4',5'-trisphosphate)
  • 1-Stearoyl-2-palmitoleoyl-sn-glycero-3-phosphoinositol-trisphosphate
  • Phosphatidylinositol Triphosphate(18:0/16:1)
  • Phosphatidylinositol Triphosphate(18:0/16:1n7)
  • Phosphatidylinositol Triphosphate(18:0/16:1w7)
genes like me logo Genes that share compounds with CNGA4: view

Transcripts for CNGA4 Gene

mRNA/cDNA for CNGA4 Gene

(4) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CNGA4 Gene

Cyclic nucleotide gated channel alpha 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for CNGA4
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for CNGA4 Gene

No ASD Table

Relevant External Links for CNGA4 Gene

GeneLoc Exon Structure for
CNGA4
ECgene alternative splicing isoforms for
CNGA4

Expression for CNGA4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CNGA4 Gene

mRNA differential expression in normal tissues according to GTEx for CNGA4 Gene

This gene is overexpressed in Testis (x10.7).

Protein differential expression in normal tissues from HIPED for CNGA4 Gene

This gene is overexpressed in Bone marrow stromal cell (67.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CNGA4 Gene



Protein tissue co-expression partners for CNGA4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CNGA4 Gene:

CNGA4

SOURCE GeneReport for Unigene cluster for CNGA4 Gene:

Hs.434618

Evidence on tissue expression from TISSUES for CNGA4 Gene

  • Lung(4.3)
  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with CNGA4: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CNGA4 Gene

Orthologs for CNGA4 Gene

This gene was present in the common ancestor of animals.

Orthologs for CNGA4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CNGA4 33 34
  • 99.48 (n)
oppossum
(Monodelphis domestica)
Mammalia CNGA4 34
  • 91 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CNGA4 33 34
  • 90.43 (n)
dog
(Canis familiaris)
Mammalia CNGA4 33 34
  • 90.09 (n)
mouse
(Mus musculus)
Mammalia Cnga4 33 16 34
  • 88.87 (n)
rat
(Rattus norvegicus)
Mammalia Cnga4 33
  • 88.64 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CNGA4 34
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves CNGA4 33 34
  • 66.94 (n)
lizard
(Anolis carolinensis)
Reptilia CNGA4 34
  • 55 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cnga4 33
  • 67.05 (n)
zebrafish
(Danio rerio)
Actinopterygii cnga4 33 34
  • 62.75 (n)
fruit fly
(Drosophila melanogaster)
Insecta Cng 34
  • 30 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea tax-4 34
  • 31 (a)
ManyToMany
che-6 34
  • 25 (a)
ManyToMany
cng-1 34
  • 25 (a)
ManyToMany
cng-3 34
  • 20 (a)
ManyToMany
cng-2 34
  • 19 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 48 (a)
OneToMany
Species where no ortholog for CNGA4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CNGA4 Gene

ENSEMBL:
Gene Tree for CNGA4 (if available)
TreeFam:
Gene Tree for CNGA4 (if available)

Paralogs for CNGA4 Gene

Paralogs for CNGA4 Gene

(5) SIMAP similar genes for CNGA4 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CNGA4: view

Variants for CNGA4 Gene

Sequence variations from dbSNP and Humsavar for CNGA4 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000315188 -- 6,243,698(+) TGCAC(A/C)AGCCA intron-variant
rs1000389592 -- 6,237,645(+) GCATT(A/G)CAAAG intron-variant, upstream-variant-2KB
rs1000423783 -- 6,237,391(+) GGATA(C/T)CCAAG intron-variant, upstream-variant-2KB
rs1000750130 -- 6,243,713(+) GTTAT(A/G)TAACT intron-variant
rs1001025053 -- 6,236,852(+) TGGGA(A/G)TTTGG intron-variant

Variation tolerance for CNGA4 Gene

Residual Variation Intolerance Score: 90.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.65; 72.80% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CNGA4 Gene

Human Gene Mutation Database (HGMD)
CNGA4
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CNGA4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CNGA4 Gene

Disorders for CNGA4 Gene

Relevant External Links for CNGA4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CNGA4

No disorders were found for CNGA4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CNGA4 Gene

Publications for CNGA4 Gene

  1. International Union of Pharmacology. LI. Nomenclature and structure-function relationships of cyclic nucleotide-regulated channels. (PMID: 16382102) Hofmann F … Kaupp UB (Pharmacological reviews 2005) 2 3 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  3. Nomenclature for ion channel subunits. (PMID: 11764791) Bradley J … Reed R (Science (New York, N.Y.) 2001) 2 3 60
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 60
  5. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor TD … Sakaki Y (Nature 2006) 4 60

Products for CNGA4 Gene

Sources for CNGA4 Gene

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