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Aliases for CNGA4 Gene

Aliases for CNGA4 Gene

  • Cyclic Nucleotide Gated Channel Alpha 4 2 3
  • Cyclic Nucleotide Gated Channel Beta 2 2 3
  • CNG Channel Alpha-4 3 4
  • CNG-4 3 4
  • CNG4 3 4
  • Cyclic Nucleotide-Gated Cation Channel Alpha-4 3
  • Cyclic Nucleotide-Gated Channel Alpha-4 4
  • OCNCBETA 3
  • OCNC2 3
  • OCNCb 3
  • CNCA2 3
  • CNGB2 3
  • CNG5 3

External Ids for CNGA4 Gene

Previous Symbols for CNGA4 Gene

  • CNCA2
  • CNGB2

Summaries for CNGA4 Gene

Entrez Gene Summary for CNGA4 Gene

  • CNGA4 is a modulatory subunit of vertebrate cyclic nucleotide-gated membrane channels that transduce odorant signals (Munger et al., 2001 [PubMed 11739959]).[supplied by OMIM, Mar 2008]

GeneCards Summary for CNGA4 Gene

CNGA4 (Cyclic Nucleotide Gated Channel Alpha 4) is a Protein Coding gene. Among its related pathways are CREB Pathway and Activation of cAMP-Dependent PKA. GO annotations related to this gene include voltage-gated potassium channel activity and cGMP binding. An important paralog of this gene is KCNH1.

UniProtKB/Swiss-Prot for CNGA4 Gene

  • Second messenger, cAMP, causes the opening of cation-selective cyclic nucleotide-gated (CNG) channels and depolarization of the neuron (olfactory sensory neurons, OSNs). CNGA4 is the modulatory subunit of this channel which is known to play a central role in the transduction of odorant signals and subsequent adaptation. By accelerating the calcium-mediated negative feedback in olfactory signaling it allows rapid adaptation to odor stimulation and extends its range of odor detection (By similarity).

Gene Wiki entry for CNGA4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CNGA4 Gene

Genomics for CNGA4 Gene

Genomic Location for CNGA4 Gene

Start:
6,234,765 bp from pter
End:
6,245,836 bp from pter
Size:
11,072 bases
Orientation:
Plus strand

Genomic View for CNGA4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CNGA4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CNGA4 Gene

Regulatory Elements for CNGA4 Gene

Proteins for CNGA4 Gene

  • Protein details for CNGA4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IV77-CNGA4_HUMAN
    Recommended name:
    Cyclic nucleotide-gated cation channel alpha-4
    Protein Accession:
    Q8IV77
    Secondary Accessions:

    Protein attributes for CNGA4 Gene

    Size:
    575 amino acids
    Molecular mass:
    65999 Da
    Quaternary structure:
    • Heterotetramer composed of two subunits of CNGA2, one of CNGA4 and one of CNGB1b. The complex forms the cyclic nucleotide-gated (CNG) channel of olfactory sensory neurons.
    SequenceCaution:
    • Sequence=AAH40277.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AK122736; Type=Frameshift; Positions=154; Evidence={ECO:0000305};

    Alternative splice isoforms for CNGA4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CNGA4 Gene

Proteomics data for CNGA4 Gene at MOPED

Post-translational modifications for CNGA4 Gene

No Post-translational modifications

Other Protein References for CNGA4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CNGA4 Gene

Domains for CNGA4 Gene

Gene Families for CNGA4 Gene

HGNC:
  • CNG :Voltage-gated ion channels / Cyclic nucleotide-regulated channels
IUPHAR :

Graphical View of Domain Structure for InterPro Entry

Q8IV77

UniProtKB/Swiss-Prot:

CNGA4_HUMAN
Domain:
  • The C-terminal coiled-coil domain mediates trimerization of CNGA subunits.:
    • Q8IV77
  • Contains 1 cyclic nucleotide-binding domain.:
    • Q8IV77
Family:
  • Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family. CNGA4 subfamily.:
    • Q8IV77
genes like me logo Genes that share domains with CNGA4: view

Function for CNGA4 Gene

Molecular function for CNGA4 Gene

UniProtKB/Swiss-Prot EnzymeRegulation: Calcium-calmodulin exerts its inhibitory effect in cAMP sensitivity by binding to IQ-like motif of CNGA4 and preferably binds to the channel in the closed state. Inhibition by PIP3 of the CNG channel probably occurs via CGNA2 binding.
UniProtKB/Swiss-Prot Function: Second messenger, cAMP, causes the opening of cation-selective cyclic nucleotide-gated (CNG) channels and depolarization of the neuron (olfactory sensory neurons, OSNs). CNGA4 is the modulatory subunit of this channel which is known to play a central role in the transduction of odorant signals and subsequent adaptation. By accelerating the calcium-mediated negative feedback in olfactory signaling it allows rapid adaptation to odor stimulation and extends its range of odor detection (By similarity).

Gene Ontology (GO) - Molecular Function for CNGA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005216 ion channel activity --
GO:0005222 intracellular cAMP activated cation channel activity IBA --
GO:0005223 intracellular cGMP activated cation channel activity IBA --
GO:0005249 voltage-gated potassium channel activity IBA --
GO:0030552 cAMP binding IEA --
genes like me logo Genes that share ontologies with CNGA4: view

Phenotypes for CNGA4 Gene

MGI mutant phenotypes for CNGA4:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with CNGA4: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CNGA4 Gene

Localization for CNGA4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CNGA4 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CNGA4 Gene COMPARTMENTS Subcellular localization image for CNGA4 gene
Compartment Confidence
plasma membrane 3
cytosol 1
endoplasmic reticulum 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CNGA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane --
GO:0030660 Golgi-associated vesicle membrane TAS --
GO:0060170 ciliary membrane TAS --
genes like me logo Genes that share ontologies with CNGA4: view

Pathways for CNGA4 Gene

genes like me logo Genes that share pathways with CNGA4: view

Pathways by source for CNGA4 Gene

Interacting Proteins for CNGA4 Gene

Gene Ontology (GO) - Biological Process for CNGA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport --
GO:0006996 organelle organization TAS --
GO:0007603 phototransduction, visible light IBA --
GO:0007608 sensory perception of smell IEA --
GO:0042391 regulation of membrane potential IBA --
genes like me logo Genes that share ontologies with CNGA4: view

Compounds for CNGA4 Gene

(18) HMDB Compounds for CNGA4 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
Cyclic AMP
  • Cyclic AMP
60-92-4
PIP3(16:0/16:0)
  • PIP3(16:0/16:0)
Not Available
PIP3(16:0/16:1(9Z))
  • PIP3(16:0/16:1w7)
Not Available
PIP3(16:0/18:1(11Z))
  • Phosphatidylinositol Triphosphate(16:0/18:1w7)
Not Available
genes like me logo Genes that share compounds with CNGA4: view

Transcripts for CNGA4 Gene

mRNA/cDNA for CNGA4 Gene

(3) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CNGA4 Gene

Cyclic nucleotide gated channel alpha 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CNGA4 Gene

No ASD Table

Relevant External Links for CNGA4 Gene

GeneLoc Exon Structure for
CNGA4
ECgene alternative splicing isoforms for
CNGA4

Expression for CNGA4 Gene

mRNA expression in normal human tissues for CNGA4 Gene

mRNA differential expression in normal tissues according to GTEx for CNGA4 Gene

This gene is overexpressed in Testis (10.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CNGA4 Gene

SOURCE GeneReport for Unigene cluster for CNGA4 Gene Hs.434618

genes like me logo Genes that share expressions with CNGA4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for CNGA4 Gene

Orthologs for CNGA4 Gene

This gene was present in the common ancestor of animals.

Orthologs for CNGA4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CNGA4 35
  • 99.48 (n)
  • 99.48 (a)
CNGA4 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CNGA4 35
  • 90.43 (n)
  • 94.09 (a)
CNGA4 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CNGA4 35
  • 90.09 (n)
  • 93.91 (a)
CNGA4 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cnga4 35
  • 88.87 (n)
  • 93.22 (a)
Cnga4 16
Cnga4 36
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CNGA4 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CNGA4 36
  • 78 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cnga4 35
  • 88.64 (n)
  • 93.39 (a)
chicken
(Gallus gallus)
Aves CNGA4 35
  • 66.94 (n)
  • 61.07 (a)
CNGA4 36
  • 55 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CNGA4 36
  • 55 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cnga4 35
  • 67.05 (n)
  • 66.15 (a)
zebrafish
(Danio rerio)
Actinopterygii cnga4 35
  • 62.75 (n)
  • 61.25 (a)
cnga4 36
  • 49 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Cng 36
  • 30 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea che-6 36
  • 25 (a)
ManyToMany
cng-1 36
  • 25 (a)
ManyToMany
cng-2 36
  • 19 (a)
ManyToMany
cng-3 36
  • 20 (a)
ManyToMany
tax-4 36
  • 31 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 48 (a)
OneToMany
Species with no ortholog for CNGA4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CNGA4 Gene

ENSEMBL:
Gene Tree for CNGA4 (if available)
TreeFam:
Gene Tree for CNGA4 (if available)

Paralogs for CNGA4 Gene

Selected SIMAP similar genes for CNGA4 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CNGA4: view

Variants for CNGA4 Gene

Sequence variations from dbSNP and Humsavar for CNGA4 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs325702 -- 6,238,271(-) ccccc(C/T)tctcc upstream-variant-2KB, intron-variant
rs325703 -- 6,238,847(-) AGGTG(A/T)CCTCT upstream-variant-2KB, intron-variant
rs325704 -- 6,243,228(-) tctca(C/G)atatt intron-variant, utr-variant-3-prime
rs325705 -- 6,243,636(-) CAAAC(C/T)GTAAG intron-variant, utr-variant-3-prime
rs325706 - 6,244,339(-) CAGGC(A/T)CACCC reference, missense, utr-variant-3-prime

Relevant External Links for CNGA4 Gene

HapMap Linkage Disequilibrium report
CNGA4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CNGA4 Gene

Disorders for CNGA4 Gene

No disorders were found for CNGA4 Gene.

No data available for UniProtKB/Swiss-Prot for CNGA4 Gene

Publications for CNGA4 Gene

  1. Nomenclature for ion channel subunits. (PMID: 11764791) Bradley J. … Reed R. (Science 2001) 2 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. International Union of Pharmacology. LI. Nomenclature and structure-function relationships of cyclic nucleotide-regulated channels. (PMID: 16382102) Hofmann F. … Kaupp U.B. (Pharmacol. Rev. 2005) 2 3
  4. Calmodulin permanently associates with rat olfactory CNG channels under native conditions. (PMID: 15195096) Bradley J. … Frings S. (Nat. Neurosci. 2004) 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4

Products for CNGA4 Gene

Sources for CNGA4 Gene

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