Aliases for CNGA2 Gene
External Ids for CNGA2 Gene
Previous HGNC Symbols for CNGA2 Gene
Previous GeneCards Identifiers for CNGA2 Gene
The protein encoded by this gene represents the alpha subunit of a cyclic nucleotide-gated olfactory channel. The encoded protein contains a carboxy-terminal leucine zipper that mediates channel formation. [provided by RefSeq, Jan 2010]
GeneCards Summary for CNGA2 Gene
CNGA2 (Cyclic Nucleotide Gated Channel Alpha 2) is a Protein Coding gene. Diseases associated with CNGA2 include Anosmia, Isolated Congenital and Cranial Nerve Malignant Neoplasm. Among its related pathways are Cargo trafficking to the periciliary membrane and Olfactory Signaling Pathway. GO annotations related to this gene include calmodulin binding and voltage-gated potassium channel activity. An important paralog of this gene is CNGA3.
UniProtKB/Swiss-Prot for CNGA2 Gene
Odorant signal transduction is probably mediated by a G-protein coupled cascade using cAMP as second messenger. The olfactory channel can be shown to be activated by cyclic nucleotides which leads to a depolarization of olfactory sensory neurons.