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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CNGA2 Gene

protein-coding   GIFtS: 50
GCID: GC0XP150904

cyclic nucleotide gated channel alpha 2


(Previous symbols: CNCA1, CNCA)
 Explore 4 diseases affiliated with
CNGA2 via our new
 Human Malady Compendium 
Biological research products
for CNGA2
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Cyclic Nucleotide Gated Channel Alpha 21 2     CNG-22 3
CNG21 2 3 5     CNG Channel Alpha-22 3
CNCA1 2 3     FLJ463121
CNCA11 2 3     OCNCalpha1
OCNC11 2 5     Cyclic Nucleotide-Gated Olfactory Channel2
OCNCALPHA1 2     Cyclic-Nucleotide-Gated Cation Channel 22
OCNCa1 2     Cyclic-Nucleotide-Gated Olfactory Channel2
Cyclic Nucleotide-Gated Cation Channel 22 3     CNCG23
Cyclic Nucleotide-Gated Channel Alpha-22 3     

External Ids:    HGNC: 21491   Entrez Gene: 12602   Ensembl: ENSG000001838627   OMIM: 3003385   UniProtKB: Q162803   

Export aliases for CNGA2 gene to outside databases

Previous GC identifers: GC0XU990031 GC0XP148659 GC0XP149529 GC0XP149520 GC0XP150573 GC0XP139760


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CNGA2:
The protein encoded by this gene represents the alpha subunit of a cyclic nucleotide-gated olfactory channel. The
encoded protein contains a carboxy-terminal leucine zipper that mediates channel formation. (provided by RefSeq, Jan
2010)

UniProtKB/Swiss-Prot: CNGA2_HUMAN, Q16280
Function: Odorant signal transduction is probably mediated by a G-protein coupled cascade using cAMP as second
messenger. The olfactory channel can be shown to be activated by cyclic nucleotides which leads to a depolarization of
olfactory sensory neurons

Gene Wiki entry for CNGA2 (Cyclic nucleotide-gated channel alpha 2)


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NC_018934.1  NT_167198.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CNGA2 gene promoter:
         USF1   C/EBPalpha   NF-YB   CHOP-10   AREB6   Pax-3   CBF-A   USF-1   HFH-1   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCNGA2 promoter sequence
   Search SABiosciences Chromatin IP Primers for CNGA2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CNGA2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq27   Ensembl cytogenetic band:  Xq28   HGNC cytogenetic band: Xq27

CNGA2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CNGA2 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP150904:  view genomic region     (about GC identifiers)

Start:
150,903,218 bp from pter      End:
150,914,036 bp from pter
Size:
10,819 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CNGA2_HUMAN, Q16280 (See protein sequence)
Recommended Name: Cyclic nucleotide-gated olfactory channel  
Size: 664 amino acids; 76048 Da
Subcellular location: Membrane; Multi-pass membrane protein
Secondary accessions: A0AVD0

Explore the universe of human proteins at neXtProt for CNGA2: NX_Q16280

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q16280

  • CNGA2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_005131.1  
    ENSEMBL proteins: 
     ENSP00000328478  

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    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0017071intracellular cyclic nucleotide activated cation channel complex NAS--


    CNGA2 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    CNGA2 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR018488 cNMP-bd_CS
     IPR018490 cNMP-bd-like
     IPR005821 Ion_trans_dom
     IPR000595 cNMP-bd_dom
     IPR014710 RmlC-like_jellyroll

    Graphical View of Domain Structure for InterPro Entry Q16280

    ProtoNet protein and cluster: Q16280

    1 Blocks protein family: IPB000595 Cyclic nucleotide-binding domain

    UniProtKB/Swiss-Prot: CNGA2_HUMAN, Q16280
    Similarity: Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family. CNGA2 subfamily
    Similarity: Contains 1 cyclic nucleotide-binding domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: CNGA2_HUMAN, Q16280
    Function: Odorant signal transduction is probably mediated by a G-protein coupled cascade using cAMP as second
    messenger. The olfactory channel can be shown to be activated by cyclic nucleotides which leads to a depolarization of
    olfactory sensory neurons

    miRNA
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    hsa-miR-30c-2* hsa-miR-219-1-3p hsa-miR-890 hsa-miR-3166 hsa-miR-30c-1* hsa-miR-1324
    SwitchGear 3'UTR luciferase reporter plasmidCNGA2 3' UTR sequence
    Inhib. RNA
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    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005216ion channel activity ----
    GO:0005222intracellular cAMP activated cation channel activity NAS--
    GO:0030552cAMP binding IEA--


    CNGA2 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for CNGA2:
     Synthetic lethal with Ras 

    Animal Models:
         Mouse knock-outs for CNGA2: Cnga2tm1Gvr Cnga2tm1Ngai Cnga2tm1Mom
         4 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Cnga2):
     growth/size  mortality/aging  nervous system  taste/olfaction 

    CNGA2 for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Potassium transporters: inward current
    Potassium transporters: inward current1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for CNGA2
        Potassium transporters- inward current




    CNGA2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CNGA2

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5/7 Interacting proteins for CNGA2 (Q162803 ENSP000003284784) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CALM1P621583, ENSP000003494674I2D: score=1 STRING: ENSP00000349467
    CALM2P621583I2D: score=1 
    CALM3P621583I2D: score=1 
    SLC9A3R1O147453, ENSP000002626134I2D: score=1 STRING: ENSP00000262613
    CNGB1ENSP000002511024STRING: ENSP00000251102
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007608sensory perception of smell NAS--
    GO:0050896response to stimulus IEA--


    CNGA2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CNGA2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CNGA2

    1 HMDB Compound for CNGA2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Cyclic AMPCyclic AMP (see all 19)60-92-4--
    1 Novoseek chemical compound relationship for CNGA2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cgmp 27.4 1 9539801 (1)

    Search CenterWatch for drugs/clinical trials and news about CNGA2 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CNGA2 gene: 
    NM_005140.1  

    Unigene Cluster for CNGA2:

    Cyclic nucleotide gated channel alpha 2
    Hs.447360  [show with all ESTs]
    Unigene Representative Sequence: NM_005140
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000329903(uc004fey.1)

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    SwitchGear 3'UTR luciferase reporter plasmidCNGA2 3' UTR sequence
    Inhib. RNA
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CNGA2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CNGA2

    Additional cDNA sequence: 

    AK128186.1 BC126302.1 BC126304.1 

    1 DOTS entry:

    DT.101958213 

    2 AceView cDNA sequences:

    NM_005140 AK128186 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CNGA2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GATACCAAAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See CNGA2 Protein Expression from SPIRE MOPED and PaxDB
    SOURCE GeneReport for Unigene cluster: Hs.447360
        SABiosciences Expression via Pathway-Focused PCR Array including CNGA2: 
              Hypertension in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CNGA2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for CNGA2 gene from 5/20 species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves CNGA21 cyclic nucleotide gated channel alpha 2 75.94(n)
    80.78(a)
      771609  XM_001234865.2  XP_001234866.2 
    lizard
    (Anolis carolinensis)
    Reptilia CNGA26
    --
    65(a)
    1 ↔ 1
    GL343376.1(1007986-1013523)
    zebrafish
    (Danio rerio)
    Actinopterygii cnga51 cyclic nucleotide gated channel alpha 5 66.25(n)
    69.2(a)
      751786  NM_001044746.1  NP_001038211.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Cng6
    CG422606
    --
    35(a)
    20(a)
    1 ↔ many
    possible ortholog
    2R(12130650-12147000)
    2R(18628504-18685794)
    worm
    (Caenorhabditis elegans)
    Secernentea tax-46
    cng-46
    (see all 5)
    Protein CNG-4
    (see all 5)
    38(a)
    27(a)
    (see all 5)
    1 ↔ many
    possible ortholog
    (see all 5)
    III(9181472-9185571)
    IV(2104056-2111605)


    ENSEMBL Gene Tree for CNGA2 (if available)
    TreeFam Gene Tree for CNGA2 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CNGA2 gene
    HCN12  KCNH62  KCNH22  KCNH72  KCNH32  CNGB12  CNGA42  KCNH52  
    HCN32  CNGA32  CNGB32  HCN42  HCN22  KCNH42  CNGA12  KCNH82  
    KCNH12  
    5 SIMAP similar genes for CNGA2 using alignment to 1 protein entry:     CNGA2_HUMAN:
    CNGA1    CNGA3    CNGA4    CNGB1    CNGB3

    CNGA2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/265 NCBI SNPs in CNGA2 are shown (see all 265    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1829171981,2
    --150901229(+) CTGTAC/TTTTTG 1 -- us2k10--------
    rs1493220711,2
    --150901284(+) ATTTCC/TCTATT 1 -- us2k10--------
    rs562619561,2
    C,--150901319(+) ACTCAT/CATGCC 1 -- us2k11Minor allele frequency- C:0.00WA 2
    rs1875118441,2
    --150901344(+) ACTGAC/TGCTTT 1 -- us2k10--------
    rs110945151,2
    C,F,A,H,--150901389(+) TTCTGA/GTTGTC 1 -- us2k116Minor allele frequency- G:0.39NS EA NA 1981
    rs575459311,2
    C,--150901525(+) CCCATG/ATAGTG 1 -- us2k11Minor allele frequency- A:0.00WA 2
    rs1924865781,2
    --150901672(+) AATTGC/TACATC 1 -- us2k10--------
    rs1848033391,2
    --150901738(+) AATTTA/GTTTGC 1 -- us2k10--------
    rs1485301501,2
    --150901756(+) ATAATG/TTCTGA 1 -- us2k10--------
    rs1875539421,2
    --150901790(+) TTACTG/TTGTTG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CNGA2 (150903218 - 150914036 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for CNGA2: --
    Locus Specific Mutation Databases (LSDB): CNGA2

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    CNGA2 for disorders           About GeneDecksing

    OMIM gene information: 300338    OMIM disorders: --

    4 diseases for CNGA2:    About MalaCards
    olfactory neuroblastoma    neuroblastoma    hypertension    neuronitis


    Export disorders for CNGA2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CNGA2 gene, integrated from 9 sources (see all 31):
    (articles sorted by number of sources associating them with CNGA2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Expression of cyclic nucleotide-gated cation channels in non-sensory tissues and cells. (PubMed id 7532814)1, 2, 3 Distler M.... Hofmann F. (1994)
    2. International Union of Pharmacology. LI. Nomenclature and structure-function relationships of cyclic nucleotide-regulated channels. (PubMed id 16382102)1, 3 Hofmann F....Kaupp U.B. (2005)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Expression of olfactory-type cyclic nucleotide-gated channel (CNGA2) in vascular tissues. (PubMed id 14618336)1, 9 Cheng K.T....Yao X. (2003)
    5. An isoform of the rod photoreceptor cyclic nucleotide-gated channel beta subunit expressed in olfactory neurons. (PubMed id 9539801)1, 9 Sautter A....Biel M. (1998)
    6. The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (2006)
    7. A single P-loop glutamate point mutation to either lysine or arginine switches the cation-anion selectivity of the CNGA2 channel. (PubMed id 16533895)1 Qu W....Barry P.H. (2006)
    8. Assembly and trafficking of a multiprotein ROMK (Kir 1.1) channel complex by PDZ interactions. (PubMed id 14604981)1 Yoo D....Welling P.A. (2004)
    9. Calcium/calmodulin modulation of olfactory and rod cyclic nucleotide-gated ion channels. (PubMed id 12626507)1 Trudeau M.C. and Zagotta W.N. (2003)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1260 HGNC: 2149 AceView: CNGA2 Ensembl:ENSG00000183862 euGenes: HUgn1260
    ECgene: CNGA2 H-InvDB: CNGA2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CNGA2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CNGA2 gene:
    Search GeneIP for patents involving CNGA2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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