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CNGA2 Gene

protein-coding   GIFtS: 52
GCID: GC0XP150904

Cyclic Nucleotide Gated Channel Alpha 2


(Previous symbols: CNCA1, CNCA)
  See CNGA2-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cyclic Nucleotide Gated Channel Alpha 21 2     OCNC12 5
CNCA1 2 3     OCNCALPHA2
CNCA11 2 3     OCNCa2
CNG22 3 5     Cyclic Nucleotide-Gated Olfactory Channel2
Cyclic Nucleotide-Gated Cation Channel 22 3     Cyclic-Nucleotide-Gated Cation Channel 22
Cyclic Nucleotide-Gated Channel Alpha-22 3     Cyclic-Nucleotide-Gated Olfactory Channel2
CNG-22 3     CNCG23
CNG Channel Alpha-22 3     

External Ids:    HGNC: 21491   Entrez Gene: 12602   Ensembl: ENSG000001838627   OMIM: 3003385   UniProtKB: Q162803   

Export aliases for CNGA2 gene to outside databases

Previous GC identifers: GC0XU990031 GC0XP148659 GC0XP149529 GC0XP149520 GC0XP150573 GC0XP139760


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CNGA2 Gene:
The protein encoded by this gene represents the alpha subunit of a cyclic nucleotide-gated olfactory channel. The
encoded protein contains a carboxy-terminal leucine zipper that mediates channel formation. (provided by RefSeq,
Jan 2010)

GeneCards Summary for CNGA2 Gene:
CNGA2 (cyclic nucleotide gated channel alpha 2) is a protein-coding gene. Diseases associated with CNGA2 include neuroblastoma. GO annotations related to this gene include cAMP binding and calmodulin binding. An important paralog of this gene is KCNH6.

UniProtKB/Swiss-Prot: CNGA2_HUMAN, Q16280
Function: Odorant signal transduction is probably mediated by a G-protein coupled cascade using cAMP as second
messenger. The olfactory channel can be shown to be activated by cyclic nucleotides which leads to a
depolarization of olfactory sensory neurons

Gene Wiki entry for CNGA2 (Cyclic nucleotide-gated channel alpha 2) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000023.10  NC_018934.2  NT_011681.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the CNGA2 gene promoter:
         USF1   C/EBPalpha   NF-YB   CHOP-10   AREB6   Pax-3   CBF-A   USF-1   HFH-1   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCNGA2 promoter sequence
   Search Chromatin IP Primers for CNGA2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CNGA2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq27   Ensembl cytogenetic band:  Xq28   HGNC cytogenetic band: Xq27

CNGA2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CNGA2 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP150904:  view genomic region     (about GC identifiers)

Start:
150,903,218 bp from pter      End:
150,914,036 bp from pter
Size:
10,819 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CNGA2_HUMAN, Q16280 (See protein sequence)
Recommended Name: Cyclic nucleotide-gated olfactory channel  
Size: 664 amino acids; 76048 Da
Subunit: Heterotetramer composed of two subunits of CNGA2, one of CNGA4 and one of CNGB1b. The complex forms the
cyclic nucleotide-gated (CNG) channel of olfactory sensory neurons (By similarity)
Secondary accessions: A0AVD0

Explore the universe of human proteins at neXtProt for CNGA2: NX_Q16280

Explore proteomics data for CNGA2 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn379
  • Modification sites at PhosphoSitePlus

  • See CNGA2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005131.1  
    ENSEMBL proteins: 
     ENSP00000328478  

    CNGA2 Human Recombinant Protein Products:

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    Browse Proteins at Cloud-Clone Corp.

     
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    antibodies-online peptides for CNGA2

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CNG: Voltage-gated ion channels / Cyclic nucleotide-regulated channels

    IUPHAR Guide to PHARMACOLOGY protein family classification: CNGA2
    Cyclic nucleotide-regulated channels

    5 InterPro protein domains:
     IPR018488 cNMP-bd_CS
     IPR018490 cNMP-bd-like
     IPR005821 Ion_trans_dom
     IPR000595 cNMP-bd_dom
     IPR014710 RmlC-like_jellyroll

    Graphical View of Domain Structure for InterPro Entry Q16280

    ProtoNet protein and cluster: Q16280

    1 Blocks protein domain: IPB000595 Cyclic nucleotide-binding domain

    UniProtKB/Swiss-Prot: CNGA2_HUMAN, Q16280
    Domain: The C-terminal coiled-coil domain mediates trimerization of CNGA subunits (By similarity)
    Similarity: Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family. CNGA2 subfamily
    Similarity: Contains 1 cyclic nucleotide-binding domain


    Find genes that share domains with CNGA2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CNGA2_HUMAN, Q16280
    Function: Odorant signal transduction is probably mediated by a G-protein coupled cascade using cAMP as second
    messenger. The olfactory channel can be shown to be activated by cyclic nucleotides which leads to a
    depolarization of olfactory sensory neurons

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005216ion channel activity ----
    GO:0005222intracellular cAMP activated cation channel activity ----
    GO:0005223intracellular cGMP activated cation channel activity IBA--
    GO:0005249voltage-gated potassium channel activity IBA--
    GO:0005516calmodulin binding IEA--
         
    Find genes that share ontologies with CNGA2           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for CNGA2:
     Synthetic lethal with Ras 

         6 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Cnga2):
     craniofacial  growth/size/body  mortality/aging  nervous system  respiratory system 
     taste/olfaction 

    Find genes that share phenotypes with CNGA2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for CNGA2: Cnga2tm1Gvr Cnga2tm1Ngai Cnga2tm1Mom

       genOway: Develop your customized and physiologically relevant rodent model for CNGA2

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    6 qRT-PCR Assays for microRNAs that regulate CNGA2:
    hsa-miR-30c-2* hsa-miR-219-1-3p hsa-miR-890 hsa-miR-3166 hsa-miR-30c-1* hsa-miR-1324
    SwitchGear 3'UTR luciferase reporter plasmidCNGA2 3' UTR sequence
    Inhib. RNA
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    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CNGA2

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CNGA2_HUMAN, Q16280: Membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3
    cytosol1
    endoplasmic reticulum1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005887integral component of plasma membrane IBA--
    GO:0016020membrane ----
    GO:0017071intracellular cyclic nucleotide activated cation channel complex ----

    Find genes that share ontologies with CNGA2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CNGA2 About    
    See pathways by source

    SuperPathContained pathways About
    1Potassium transporters inward current
    Potassium transporters inward current



        Pathway & Disease-focused RT2 Profiler PCR Array including CNGA2: 
              Hypertension in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for CNGA2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    Selected Interacting proteins for CNGA2 (Q162803 ENSP000003284784) via UniProtKB, MINT, STRING, and/or I2D (see all 14)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CALM1P621583, ENSP000003494674I2D: score=1 STRING: ENSP00000349467
    CALM2P621583I2D: score=1 
    CALM3P621583I2D: score=1 
    SLC9A3R1O147453, ENSP000002626134I2D: score=1 STRING: ENSP00000262613
    CNGA4ENSP000003692684STRING: ENSP00000369268
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006811ion transport ----
    GO:0007603phototransduction, visible light IBA--
    GO:0007608sensory perception of smell IEA--
    GO:0042391regulation of membrane potential IBA--
    GO:0055085transmembrane transport ----

    Find genes that share ontologies with CNGA2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CNGA2

    1 HMDB Compound for CNGA2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Cyclic AMPCyclic AMP (see all 19)60-92-4--

    1 Novoseek inferred chemical compound relationship for CNGA2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cgmp 27.4 1 9539801 (1)



    Find genes that share compounds with CNGA2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CNGA2 gene: 
    NM_005140.1  

    Unigene Cluster for CNGA2:

    Cyclic nucleotide gated channel alpha 2
    Hs.447360  [show with all ESTs]
    Unigene Representative Sequence: NM_005140
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000329903(uc004fey.1)
    miRNA
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    hsa-miR-30c-2* hsa-miR-219-1-3p hsa-miR-890 hsa-miR-3166 hsa-miR-30c-1* hsa-miR-1324
    SwitchGear 3'UTR luciferase reporter plasmidCNGA2 3' UTR sequence
    Inhib. RNA
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    Primer
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      QuantiFast Probe-based Assays in human, mouse, rat CNGA2

    Additional mRNA sequence: 

    AK128186.1 BC126302.1 BC126304.1 

    1 DOTS entry:

    DT.101958213 

    2 AceView cDNA sequences:

    NM_005140 AK128186 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CNGA2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GATACCAAAA
    CNGA2 Expression
    About this image

    CNGA2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CNGA2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.447360
        Pathway & Disease-focused RT2 Profiler PCR Array including CNGA2: 
              Hypertension in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CNGA2 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cnga21 , 5 cyclic nucleotide gated channel alpha 21, 5 88.17(n)1
    93.96(a)1
      X (37.15 cM)5
    127891  NM_007724.21  NP_031750.21 
     719918495 
    chicken
    (Gallus gallus)
    Aves CNGA21 cyclic nucleotide gated channel alpha 2 74.04(n)
    77.57(a)
      771609  XM_001234865.3  XP_001234866.3 
    lizard
    (Anolis carolinensis)
    Reptilia CNGA26
    cyclic nucleotide gated channel alpha 2
    65(a)
    1 ↔ 1
    GL343376.1(1007986-1013523)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia cnga21 cyclic nucleotide gated channel alpha 2 67.58(n)
    69.05(a)
      100494874  XM_002939200.2  XP_002939246.1 
    zebrafish
    (Danio rerio)
    Actinopterygii cnga51 cyclic nucleotide gated channel alpha 5 66.25(n)
    69.2(a)
      751786  NM_001044746.1  NP_001038211.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Cng6
    Cyclic-nucleotide-gated ion channel protein
    37(a)
    1 → many
    2R(12130650-12147000)
    worm
    (Caenorhabditis elegans)
    Secernentea tax-46
    cng-16
    (see all 5)
    Protein TAX-4 (tax-4) mRNA, complete cds
    Protein CNG-1, isoform b (cng-1) mRNA, complete cd...
    (see all 5)
    39(a)
    31(a)
    (see all 5)
    many ↔ many
    many ↔ many
    (see all 5)
    III(9181550-9185649) WBGene00006526
    V(15025740-15031473) WBGene00000562


    ENSEMBL Gene Tree for CNGA2 (if available)
    TreeFam Gene Tree for CNGA2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CNGA2 gene
    KCNH62  KCNH32  KCNH52  HCN32  HCN42  KCNH42  HCN22  CNGA12  
    HCN12  KCNH22  KCNH72  CNGB12  CNGA42  CNGA32  CNGB32  KCNH82  
    KCNH12  
    4 SIMAP similar genes for CNGA2 using alignment to 1 protein entry:     CNGA2_HUMAN:
    CNGA1    CNGA3    CNGA4    CNGB3

    Find genes that share paralogs with CNGA2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CNGA2 (see all 357)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0366044
    A breast cancer sample4--see VAR_0366042 R Q mis40--------
    VAR_0366034
    A breast cancer sample4--see VAR_0366032 R H mis40--------
    rs1829171981,2
    C--150767607(+) CTGTAC/TTTTTG 1 -- us2k10--------
    rs1493220711,2
    --150767662(+) ATTTCC/TCTATT 1 -- us2k10--------
    rs562619561,2
    C,F--150767697(+) ACTCAT/CATGCC 1 -- us2k11Minor allele frequency- C:0.00WA 2
    rs1875118441,2
    --150767722(+) ACTGAC/TGCTTT 1 -- us2k10--------
    rs110945151,2
    C,F,A,H--150767767(+) TTCTGA/GTTGTC 1 -- us2k116Minor allele frequency- G:0.39NS EA NA 1981
    rs575459311,2
    C,F--150767903(+) CCCATG/ATAGTG 1 -- us2k11Minor allele frequency- A:0.00WA 2
    rs1924865781,2
    --150768050(+) AATTGC/TACATC 1 -- us2k10--------
    rs1848033391,2
    C--150768116(+) AATTTA/GTTTGC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CNGA2 (150903218 - 150914036 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for CNGA2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv518142CNV Gain19592680

    Locus Specific Mutation Databases (LSDB): CNGA2

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CNGA2
    DNA2.0 Custom Variant and Variant Library Synthesis for CNGA2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 300338    OMIM disorders: --

    1 disease for CNGA2:    
    About MalaCards
    neuroblastoma

    1 disease from the University of Copenhagen DISEASES database for CNGA2:
    Olfactory neuroblastoma

    Find genes that share disorders with CNGA2           About GenesLikeMe


    Export disorders for CNGA2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CNGA2 gene, integrated from 10 sources (see all 31):
    (articles sorted by number of sources associating them with CNGA2)
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    1. Expression of cyclic nucleotide-gated cation channels in non-sensory tissues and cells. (PubMed id 7532814)1, 2, 3 Distler M.... Hofmann F. (Neuropharmacology 1994)
    2. International Union of Pharmacology. LI. Nomenclature and structure-function relationships of cyclic nucleotide-regulated channels. (PubMed id 16382102)1, 3 Hofmann F....Kaupp U.B. (Pharmacol. Rev. 2005)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Expression of olfactory-type cyclic nucleotide-gated channel (CNGA2) in vascular tissues. (PubMed id 14618336)1, 9 Cheng K.T....Yao X. (Histochem. Cell Biol. 2003)
    5. An isoform of the rod photoreceptor cyclic nucleotide-gated channel beta subunit expressed in olfactory neurons. (PubMed id 9539801)1, 9 Sautter A....Biel M. (Proc. Natl. Acad. Sci. U.S.A. 1998)
    6. The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (Science 2006)
    7. A single P-loop glutamate point mutation to either lysine or arginine switches the cation-anion selectivity of the CNGA2 channel. (PubMed id 16533895)1 Qu W....Barry P.H. (J. Gen. Physiol. 2006)
    8. Assembly and trafficking of a multiprotein ROMK (Kir 1.1) channel complex by PDZ interactions. (PubMed id 14604981)1 Yoo D....Welling P.A. (J. Biol. Chem. 2004)
    9. Calcium/calmodulin modulation of olfactory and rod cyclic nucleotide-gated ion channels. (PubMed id 12626507)1 Trudeau M.C. and Zagotta W.N. (J. Biol. Chem. 2003)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1260 HGNC: 2149 AceView: CNGA2 Ensembl:ENSG00000183862 euGenes: HUgn1260
    ECgene: CNGA2 H-InvDB: CNGA2

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CNGA2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CNGA2 gene:
    Search GeneIP for patents involving CNGA2

    GeneCards and IP:
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