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Aliases for CNGA2 Gene

Aliases for CNGA2 Gene

  • Cyclic Nucleotide Gated Channel Alpha 2 2 3
  • CNG Channel Alpha-2 3 4
  • CNCA1 3 4
  • CNCA 3 4
  • CNG2 3 4
  • Cyclic-Nucleotide-Gated Cation Channel 2 3
  • Cyclic Nucleotide-Gated Cation Channel 2 4
  • Cyclic Nucleotide-Gated Channel Alpha-2 4
  • OCNCALPHA 3
  • CNCG2 4
  • OCNC1 3
  • OCNCa 3
  • CNG-2 4

External Ids for CNGA2 Gene

Previous HGNC Symbols for CNGA2 Gene

  • CNCA1
  • CNCA

Previous GeneCards Identifiers for CNGA2 Gene

  • GC0XU990031
  • GC0XP148659
  • GC0XP149529
  • GC0XP149520
  • GC0XP150573
  • GC0XP150904
  • GC0XP139760

Summaries for CNGA2 Gene

Entrez Gene Summary for CNGA2 Gene

  • The protein encoded by this gene represents the alpha subunit of a cyclic nucleotide-gated olfactory channel. The encoded protein contains a carboxy-terminal leucine zipper that mediates channel formation. [provided by RefSeq, Jan 2010]

GeneCards Summary for CNGA2 Gene

CNGA2 (Cyclic Nucleotide Gated Channel Alpha 2) is a Protein Coding gene. Diseases associated with CNGA2 include cranial nerve malignant neoplasm and olfactory nerve neoplasm. Among its related pathways are Organelle biogenesis and maintenance and Cargo trafficking to the periciliary membrane. GO annotations related to this gene include calmodulin binding and voltage-gated potassium channel activity. An important paralog of this gene is KCNH1.

UniProtKB/Swiss-Prot for CNGA2 Gene

  • Odorant signal transduction is probably mediated by a G-protein coupled cascade using cAMP as second messenger. The olfactory channel can be shown to be activated by cyclic nucleotides which leads to a depolarization of olfactory sensory neurons

Gene Wiki entry for CNGA2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CNGA2 Gene

Genomics for CNGA2 Gene

Regulatory Elements for CNGA2 Gene

Genomic Location for CNGA2 Gene

Chromosome:
X
Start:
151,734,746 bp from pter
End:
151,745,564 bp from pter
Size:
10,819 bases
Orientation:
Plus strand

Genomic View for CNGA2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CNGA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CNGA2 Gene

Proteins for CNGA2 Gene

  • Protein details for CNGA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16280-CNGA2_HUMAN
    Recommended name:
    Cyclic nucleotide-gated olfactory channel
    Protein Accession:
    Q16280
    Secondary Accessions:
    • A0AVD0

    Protein attributes for CNGA2 Gene

    Size:
    664 amino acids
    Molecular mass:
    76048 Da
    Quaternary structure:
    • Heterotetramer composed of two subunits of CNGA2, one of CNGA4 and one of CNGB1b. The complex forms the cyclic nucleotide-gated (CNG) channel of olfactory sensory neurons (By similarity).

neXtProt entry for CNGA2 Gene

Proteomics data for CNGA2 Gene at MOPED

Post-translational modifications for CNGA2 Gene

  • Glycosylation at Asn 379
  • Modification sites at PhosphoSitePlus

Other Protein References for CNGA2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for CNGA2 Gene

Domains & Families for CNGA2 Gene

Gene Families for CNGA2 Gene

Suggested Antigen Peptide Sequences for CNGA2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q16280

UniProtKB/Swiss-Prot:

CNGA2_HUMAN :
  • The C-terminal coiled-coil domain mediates trimerization of CNGA subunits.
  • Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family. CNGA2 subfamily.
Domain:
  • The C-terminal coiled-coil domain mediates trimerization of CNGA subunits.
  • Contains 1 cyclic nucleotide-binding domain.
Family:
  • Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family. CNGA2 subfamily.
genes like me logo Genes that share domains with CNGA2: view

Function for CNGA2 Gene

Molecular function for CNGA2 Gene

UniProtKB/Swiss-Prot Function:
Odorant signal transduction is probably mediated by a G-protein coupled cascade using cAMP as second messenger. The olfactory channel can be shown to be activated by cyclic nucleotides which leads to a depolarization of olfactory sensory neurons

Gene Ontology (GO) - Molecular Function for CNGA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005216 ion channel activity --
GO:0005222 intracellular cAMP activated cation channel activity IBA --
GO:0005223 intracellular cGMP activated cation channel activity IBA --
GO:0005249 voltage-gated potassium channel activity IBA --
GO:0005516 calmodulin binding IEA --
genes like me logo Genes that share ontologies with CNGA2: view
genes like me logo Genes that share phenotypes with CNGA2: view

Animal Models for CNGA2 Gene

MGI Knock Outs for CNGA2:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CNGA2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for CNGA2 Gene

Localization for CNGA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CNGA2 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CNGA2 Gene COMPARTMENTS Subcellular localization image for CNGA2 gene
Compartment Confidence
golgi apparatus 4
plasma membrane 4
cytosol 1

Gene Ontology (GO) - Cellular Components for CNGA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane --
GO:0030660 Golgi-associated vesicle membrane TAS --
GO:0060170 ciliary membrane TAS --
genes like me logo Genes that share ontologies with CNGA2: view

Pathways & Interactions for CNGA2 Gene

genes like me logo Genes that share pathways with CNGA2: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for CNGA2 Gene

Gene Ontology (GO) - Biological Process for CNGA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport --
GO:0006996 organelle organization TAS --
GO:0007608 sensory perception of smell IEA --
GO:0042391 regulation of membrane potential IBA --
GO:0050896 response to stimulus IEA --
genes like me logo Genes that share ontologies with CNGA2: view

No data available for SIGNOR curated interactions for CNGA2 Gene

Drugs & Compounds for CNGA2 Gene

(2) Drugs for CNGA2 Gene - From: HMDB and NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
cyclic amp Experimental Pharma 0
cgmp Pharma Activation, Activator 0
genes like me logo Genes that share compounds with CNGA2: view

Transcripts for CNGA2 Gene

mRNA/cDNA for CNGA2 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CNGA2 Gene

Cyclic nucleotide gated channel alpha 2:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CNGA2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CNGA2 Gene

No ASD Table

Relevant External Links for CNGA2 Gene

GeneLoc Exon Structure for
CNGA2
ECgene alternative splicing isoforms for
CNGA2

Expression for CNGA2 Gene

mRNA expression in normal human tissues for CNGA2 Gene

mRNA differential expression in normal tissues according to GTEx for CNGA2 Gene

This gene is overexpressed in Testis (x46.3).

Protein differential expression in normal tissues from HIPED for CNGA2 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CNGA2 Gene



SOURCE GeneReport for Unigene cluster for CNGA2 Gene Hs.447360

genes like me logo Genes that share expression patterns with CNGA2: view

Protein tissue co-expression partners for CNGA2 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for CNGA2 Gene

Orthologs for CNGA2 Gene

This gene was present in the common ancestor of animals.

Orthologs for CNGA2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CNGA2 35
  • 89.85 (n)
  • 93.79 (a)
CNGA2 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CNGA2 35
  • 90.56 (n)
  • 94.73 (a)
CNGA2 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cnga2 35
  • 88.17 (n)
  • 93.96 (a)
Cnga2 16
Cnga2 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CNGA2 35
  • 99.5 (n)
  • 99.25 (a)
CNGA2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cnga2 35
  • 87.56 (n)
  • 92.9 (a)
oppossum
(Monodelphis domestica)
Mammalia CNGA2 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CNGA2 36
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves CNGA2 35
  • 74.04 (n)
  • 77.57 (a)
CNGA2 36
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CNGA2 36
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cnga2 35
  • 67.58 (n)
  • 69.05 (a)
zebrafish
(Danio rerio)
Actinopterygii cnga5 35
  • 66.25 (n)
  • 69.2 (a)
cnga5 36
  • 66 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Cng 36
  • 37 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea che-6 36
  • 30 (a)
ManyToMany
cng-1 36
  • 31 (a)
ManyToMany
cng-2 36
  • 23 (a)
ManyToMany
cng-3 36
  • 22 (a)
ManyToMany
tax-4 36
  • 39 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 57 (a)
OneToMany
Species with no ortholog for CNGA2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CNGA2 Gene

ENSEMBL:
Gene Tree for CNGA2 (if available)
TreeFam:
Gene Tree for CNGA2 (if available)

Paralogs for CNGA2 Gene

(4) SIMAP similar genes for CNGA2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CNGA2: view

Variants for CNGA2 Gene

Sequence variations from dbSNP and Humsavar for CNGA2 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs714147 - 151,744,490(+) CTGAC(A/G)AGCCA missense, reference
rs733871 -- 151,740,124(+) GAGGG(A/C)TGGAG intron-variant
rs879371 -- 151,745,003(+) CCCCA(A/T)CAGAT utr-variant-3-prime
rs879372 -- 151,744,801(+) GCGAC(C/T)CCTCC utr-variant-3-prime
rs881441 -- 151,746,047(-) ttcat(G/T)tgttc downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for CNGA2 Gene

Variant ID Type Subtype PubMed ID
nsv518142 CNV Gain 19592680

Variation tolerance for CNGA2 Gene

Residual Variation Intolerance Score: 87.87% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.12; 80.60% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CNGA2 Gene

HapMap Linkage Disequilibrium report
CNGA2
Human Gene Mutation Database (HGMD)
CNGA2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CNGA2 Gene

Disorders for CNGA2 Gene

MalaCards: The human disease database

(3) MalaCards diseases for CNGA2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
cranial nerve malignant neoplasm
  • malignant neoplasm of cranial nerves nos
olfactory nerve neoplasm
  • tumor of olfactory nerve
stickler syndrome
  • cleft lip and palate
- elite association
Search CNGA2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CNGA2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CNGA2
genes like me logo Genes that share disorders with CNGA2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CNGA2 Gene

Publications for CNGA2 Gene

  1. Electrophysiology of hyperpolarization-activated cyclic nucleotide-gated cation channel 2 and hyperpolarization-activated cyclic nucleotide-gated cation channel 4 expressed in HEK293 cells. (PMID: 18067793) Li C. … Wang S.Q. (Chin. Med. J. 2007) 23 67
  2. Odorant inhibition of the olfactory cyclic nucleotide-gated channel with a native molecular assembly. (PMID: 16940558) Chen T.Y. … Kurahashi T. (J. Gen. Physiol. 2006) 23 67
  3. Interplay between PIP3 and calmodulin regulation of olfactory cyclic nucleotide-gated channels. (PMID: 17032767) Brady J.D. … Brown R.L. (Proc. Natl. Acad. Sci. U.S.A. 2006) 23 67
  4. International Union of Pharmacology. LI. Nomenclature and structure-function relationships of cyclic nucleotide-regulated channels. (PMID: 16382102) Hofmann F. … Kaupp U.B. (Pharmacol. Rev. 2005) 2 67
  5. Structure of calmodulin complexed with an olfactory CNG channel fragment and role of the central linker: residual dipolar couplings to evaluate calmodulin binding modes outside the kinase family. (PMID: 15803393) Contessa G.M. … Cicero D.O. (J. Biomol. NMR 2005) 23 67

Products for CNGA2 Gene

Sources for CNGA2 Gene

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