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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CNGA1 Gene

protein-coding   GIFtS: 63
GCID: GC04M047853

cyclic nucleotide gated channel alpha 1


(Previous symbols: CNCG1, CNCG)
 Explore 8 diseases affiliated with
CNGA1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CNGA1    

Aliases
for CNGA1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Cyclic Nucleotide Gated Channel Alpha 11 2     Cyclic Nucleotide-Gated Channel Alpha-12 3
CNCG11 2 3 5     Cyclic Nucleotide-Gated Channel, Photoreceptor2 3
CNCG1 2 3     Rod Photoreceptor CGMP-Gated Channel Subunit Alpha2 3
CNG11 2 3     CNG-12 3
RP491 2 5     CNG Channel Alpha-12 3
RCNC11 2     RCNCalpha2
RCNCa1 2     CGMP-Gated Cation Channel Alpha-12
Cyclic Nucleotide-Gated Cation Channel 12 3     Interleukin-1 Homologue2

External Ids:    HGNC: 21481   Entrez Gene: 12592   Ensembl: ENSG000001985157   OMIM: 1238255   UniProtKB: P299733   

Export aliases for CNGA1 gene to outside databases

Previous GC identifers: GC04M048014 GC04M048247 GC04M047787 GC04M047778 GC04M047632 GC04M047257


Summaries
for CNGA1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CNGA1:
The protein encoded by this gene is involved in phototransduction. Along with another protein, the encoded protein
forms a cGMP-gated cation channel in the plasma membrane, allowing depolarization of rod photoreceptors. This
represents the last step in the phototransduction pathway. Defects in this gene are a cause of retinitis pigmentosa
autosomal recessive (ARRP) disease. Two transcript variants encoding different isoforms have been found for this gene.
(provided by RefSeq, Dec 2008)

UniProtKB/Swiss-Prot: CNGA1_HUMAN, P29973
Function: Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This
protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a
depolarization of rod photoreceptors

Gene Wiki entry for CNGA1 (Cyclic nucleotide-gated channel alpha 1)


Genomic Views
for CNGA1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.1  NT_006238.11  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CNGA1 gene promoter:
         NF-YB   CBF-B   CBF-A   NF-YA   NF-YC   CP1C   CP1A   NF-Y   CBF-C   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CNGA1 promoter sequence
   Search SABiosciences Chromatin IP Primers for CNGA1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CNGA1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p12   Ensembl cytogenetic band:  4p12   HGNC cytogenetic band: 4p12

CNGA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CNGA1 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M047853:  view genomic region     (about GC identifiers)

Start:
 47,937,994 bp from pter      End:
 48,018,689 bp from pter
Size:
 80,696 bases      Orientation:
 minus strand

Proteins
for CNGA1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CNGA1_HUMAN, P29973 (See protein sequence)
Recommended Name: cGMP-gated cation channel alpha-1  
Size: 690 amino acids; 79586 Da
Subunit: Homotetramer or higher oligomer. Forms heterooligomeric complex with CNG4
Subcellular location: Membrane; Multi-pass membrane protein
Caution: It is uncertain whether Met-1 or Met-5 is the initiator
Sequence caution: Sequence=AAB22778.1; Type=Erroneous initiation;
Secondary accessions: A8K7K6 Q16279 Q16485 Q4W5E3

Explore the universe of human proteins at neXtProt for CNGA1: NX_P29973

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P29973

    • CNGA1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_000078.2  NP_001136036.1  

    ENSEMBL proteins: 
     ENSP00000384264   ENSP00000426862   ENSP00000389881   ENSP00000423721   ENSP00000421110  
     ENSP00000423327   ENSP00000443401   ENSP00000351320  

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    Browse Proteins at Uscn

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001750photoreceptor outer segment ----
    GO:0005624membrane fraction ----
    GO:0005887integral to plasma membrane TAS7479749
    GO:0042622photoreceptor outer segment membrane ----


    CNGA1 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for CNGA1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CNGA1 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR018488 cNMP-bd_CS
     IPR018490 cNMP-bd-like
     IPR005821 Ion_trans_dom
     IPR000595 cNMP-bd_dom
     IPR014710 RmlC-like_jellyroll

    Graphical View of Domain Structure for InterPro Entry P29973

    ProtoNet protein and cluster: P29973

    1 Blocks protein family: IPB000595 Cyclic nucleotide-binding domain

    UniProtKB/Swiss-Prot: CNGA1_HUMAN, P29973
    Similarity: Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family. CNGA1 subfamily
    Similarity: Contains 1 cyclic nucleotide-binding domain


    Function
    for CNGA1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: CNGA1_HUMAN, P29973
    Function: Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This
    protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a
    depolarization of rod photoreceptors

         Genatlas biochemistry entry for CNGA1:
    cyclic guanine nucleotide gated channel (cGMP),rod photoreceptor,expressed in the rod outer segment alpha 1
    subunit,heterodimerizing with CNGB4

    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmid: CNGA1 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    Cell Line
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    In Situ Assay
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005216ion channel activity IEA--
    GO:0030553cGMP binding IEA--


    CNGA1 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for CNGA1:
     Decreased viability with pacli  Increased homologous recombina 


    Pathways & Interactions
    for CNGA1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/8 super-pathways (see all 8) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Activation of cAMP-Dependent PKA
    		Activation of cAMP-Dependent PKA1.00
    		PKA Signaling0.56
    		cAMP Pathway0.77
    2Visual signal transduction- Rods
    		Visual signal transduction- Rods1.00
    		Phototransduction0.44
    3Sweet Taste Signaling
    		Cellular Effects of Sildenafil0.46
    		Sperm Motility0.36
    4Potassium transporters: inward current
    		Potassium transporters: inward current1.00
    5Visual Cycle in Retinal Rods
    		Visual Cycle in Retinal Rods1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for CNGA1
        Potassium transporters- inward current

    5/9 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CNGA1 (see all 9)
        Cellular Effects of Sildenafil
    Cholera Infection
    PKA Signaling
    eNOS Signaling
    cAMP Pathway

    1 BioSystems Pathway for CNGA1 
        Visual signal transduction- Rods


    1         Kegg Pathway  (Kegg details for CNGA1):
        Phototransduction


    CNGA1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CNGA1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    5/13 Interacting proteins for CNGA1 (P299732, 3 ENSP000003842644) via UniProtKB, MINT, STRING, and/or I2D (see all 13)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SLC24A1O607213, ENSP000002618924I2D: score=2 STRING: ENSP00000261892
    GJA1P173023I2D: score=1 
    GRB14Q144493I2D: score=1 
    GNAT1ENSP000002324614STRING: ENSP00000232461
    PDE6AENSP000002552664STRING: ENSP00000255266
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport TAS7479749
    GO:0007601visual perception IEA--
    GO:0050896response to stimulus IEA--


    CNGA1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for CNGA1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for CNGA1

    1 HMDB Compound for CNGA1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Cyclic GMP3',5'-cyclic GMP (see all 13)7665-99-8--
    Search CenterWatch for drugs/clinical trials and news about CNGA1 

    Transcripts
    for CNGA1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CNGA1 gene (2 alternative transcripts): 
    NM_000087.3  NM_001142564.1  

    Unigene Cluster for CNGA1:

    Cyclic nucleotide gated channel alpha 1
    Hs.1323  [show with all ESTs]
    Unigene Representative Sequence: NM_001142564
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000402813(uc003gxu.3) ENST00000514170(uc003gxv.1) ENST00000420489(uc003gxt.4)
    ENST00000506118 ENST00000504722 ENST00000514520 ENST00000513178 ENST00000544810
    ENST00000358519

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    1 QIAGEN miScript miRNA Assays for microRNA that regulate CNGA1:
    hsa-miR-330-3p
    SwitchGear 3'UTR luciferase reporter plasmid: CNGA1 3' UTR sequence
    Inhib. RNA
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AK292021.1 M84741.1 S42457.1 X64802.1 

    6 DOTS entries:

    DT.312592  DT.100659925  DT.99932944  DT.121240741  DT.40306891  DT.95175958 

    24/46 AceView cDNA sequences (see all 46):

    AI800043 BM693218 BX109510 W93472 BM696079 AI206400 BM664585 AI669887 
    BM668529 BM677264 AL711841 AL711805 NM_000087 AW269147 BM721661 S42457 
    BX500913 BQ637979 M84741 W57704 BM932193 BX509701 AI380866 W89169 

    GeneLoc Exon Structure


    Expression
    for CNGA1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CNGA1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TACATCATAT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    CNGA1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    EyeOuter Nuclear LayerMature Rod CellsPhotoreceptors, Retina
    BoneZeugopod Growth PlateBone
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 2 LifeMap Cells 
    NameCategory
    Photoreceptor-like cells (Generation of retina...)Eye
    Photoreceptor-like cells (Generation of retina...)

    See CNGA1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CNGA1

    SOURCE GeneReport for Unigene cluster: Hs.1323

    UniProtKB/Swiss-Prot: CNGA1_HUMAN, P29973
    Tissue specificity: Rod cells in the retina

        SABiosciences Expression via Pathway-Focused PCR Array including CNGA1: 
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    In Situ
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    Orthologs
    for CNGA1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for CNGA1 gene from 5/20 species (see all 20)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves CNGA11 cyclic nucleotide gated channel alpha 1 76.98(n)
    81.43(a)    		   396143  NM_205220.1  NP_990551.1 
    lizard
    (Anolis carolinensis)    		 Reptilia CNGA16
    		 --
    		 76(a)
    		 1 ↔ 1
    		 GL343293.1(592340-602150)
    zebrafish
    (Danio rerio)    		 Actinopterygii LOC5722491 cyclic nucleotide-gated channel rod photoreceptor subunit more 69.35(n)
    76.88(a)    		   572249  XM_695944.5  XP_701036.4 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG35363 intracellular cyclic nucleotide activated
    cation more    		 59(a)
    (best of 3)    		   59A4   --
    worm
    (Caenorhabditis elegans)    		 Secernentea tax-41 , 3 Cyclic-nucleotide-gated olfactory channel3
    Protein TAX-41    		 51(a)
    (best of 5)3
    57.44(n)1
    58.37(a)1    		   III(9253275-9257290)3
    1762971  NM_066632.31  NP_499033.11 


    ENSEMBL Gene Tree for CNGA1 (if available)
    TreeFam Gene Tree for CNGA1 (if available) 

    Paralogs
    for CNGA1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CNGA1 gene
    HCN12  KCNH62  KCNH22  KCNH72  KCNH32  CNGB12  CNGA42  KCNH52  
    HCN32  CNGA32  CNGB32  HCN42  HCN22  KCNH42  CNGA22  KCNH82  
    KCNH12  
    18/20 SIMAP similar genes for CNGA1 using alignment to 4 protein entries:     CNGA1_HUMAN (see all proteins) (see all similar genes):
    OK/SW-cl.41    COQ5    DNAPTP3    FP6651    CNGA2    CNGA3
    CNGA4    FAM138A    FAM138B    FAM138C    FAM138F    FAM138D
    FLJ20555    UTY    LINC00269    FP6778    CNGB1    LOC100996300

    CNGA1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for CNGA1
    PGOHUM00000242361


    Genomic Variants
    for CNGA1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 3 variations for CNGA1
         1 CNV: 98707
         2 Indels: 12446 46655
    Human Gene Mutation Database (HGMD): CNGA1

    Locus Specific Mutation Databases (LSDB): CNGA1
    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CNGA1
    DNA2.0 Custom Variant and Variant Library Synthesis for CNGA1

    Disorders / Diseases
    for CNGA1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CNGA1 for disorders           About GeneDecksing

    OMIM gene information: 123825    OMIM disorders: --

    UniProtKB/Swiss-Prot: CNGA1_HUMAN, P29973
  • Defects in CNGA1 are the cause of retinitis pigmentosa type 49 (RP49) [MIM:613756]. RP leads to degeneration
    • of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field.
    As their condition progresses, they lose their far peripheral visual field and eventually central vision as well

    8 diseases for CNGA1:    About MalaCards
    retinitis pigmentosa    retinitis pigmentosa-49    retinitis    hypertrichosis
    retinal disease    blindness    hypertension    neuronitis

    1 disease from the University of Copenhagen DISEASES database for CNGA1:
    Hypertrichosis

    1 Novoseek disease relationship for CNGA1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinitis pigmentosa 66.1 2 12362048 (1), 11970862 (1)

    Human Genome Epidemiology (HuGE) Navigator: CNGA1 (1 document)

    Export disorders for CNGA1 gene to outside databases

    Publications
    for CNGA1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CNGA1 gene, integrated from 9 sources (see all 27):
    (articles sorted by number of sources associating them with CNGA1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Human rod photoreceptor cGMP-gated channel: amino acid sequence, gene structure, and functional expression. (PubMed id 1379636)1, 2, 9 Dhallan R.S....Nathans J. (1992)
    2. International Union of Pharmacology. LI. Nomenclature and structure-function relationships of cyclic nucleotide-regulated channels. (PubMed id 16382102)1, 3 Hofmann F....Kaupp U.B. (2005)
    3. Autosomal recessive retinitis pigmentosa in a Pakistani family mapped to CNGA1 with identification of a novel mutation. (PubMed id 15570217)1, 2 Zhang Q.... Hejtmancik J.F. (2004)
    4. Mutations in the gene encoding the alpha subunit of the rod cGMP- gated channel in autosomal recessive retinitis pigmentosa. (PubMed id 7479749)1, 2 Dryja T.P.... Yau K.-W. (1995)
    5. Expression of cyclic nucleotide-gated cation channels in non-sensory tissues and cells. (PubMed id 7532814)1, 2 Distler M.... Hofmann F. (1994)
    6. Human rod cGMP-gated cation channel gene maps to 4p12-->centromere by chromosomal in situ hybridization. (PubMed id 7683629)1, 3 Griffin C.A....Levine M.A. (1993)
    7. Primary structure and chromosomal localization of human and mouse rod photoreceptor cGMP-gated cation channel. (PubMed id 1372902)1, 2 Pittler S.J.... Baehr W. (1992)
    8. Novel homozygous mutation in the alpha subunit of the rod cGMP gated channel (CNGA1) in two Spanish sibs affected with autosomal recessive retinitis pigmentosa. (PubMed id 12362048)1, 9 Paloma E....Balcells S. (2002)
    9. Insulin receptor regulates photoreceptor CNG channel a ctivity. (PubMed id 23032687)1 Gupta V.K....Rajala R.V. (2012)
    10. Simultaneous Mutation Detection in 90 Retinal Disease Genes in Multiple Patients Using a Custom-designed 300-kb Retinal Resequencing Chip. (PubMed id 20801516)1 Booij J.C....Florijn R.J. (2010)

    External Searches for CNGA1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing CNGA1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1259 HGNC: 2148 AceView: CNGA1 Ensembl:ENSG00000198515 euGenes: HUgn1259
    ECgene: CNGA1 Kegg: 1259 H-InvDB: CNGA1

    Other Databases showing CNGA1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CNGA1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CNGA1 Pharmacogenomics, SNPs, Pathways
    Mutations of the CNGA1 genehttp://www.retina-international.org/files/sci-news/cnga1mut.htm
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/CNGA1

    Intellectual Property
    for CNGA1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CNGA1 gene:
    Search GeneIP for patents involving CNGA1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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