Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CNEP1R1 Gene

Aliases for CNEP1R1 Gene

  • CTD Nuclear Envelope Phosphatase 1 Regulatory Subunit 1 2 3
  • Transmembrane Protein 188 2 3 4
  • Nuclear Envelope Phosphatase 1-Regulatory Subunit 1 2 3
  • C16orf69 3 4
  • TMEM188 3 4
  • NEP1-R1 3 4
  • Nuclear Envelope Phosphatase-Regulatory Subunit 1 3
  • Chromosome 16 Open Reading Frame 69 2
  • TMP125 3

External Ids for CNEP1R1 Gene

Previous HGNC Symbols for CNEP1R1 Gene

  • C16orf69
  • TMEM188

Previous GeneCards Identifiers for CNEP1R1 Gene

  • GC16P050058

Summaries for CNEP1R1 Gene

Entrez Gene Summary for CNEP1R1 Gene

  • This gene encodes a transmembrane protein that belongs to the Tmemb_18A family. A similar protein in yeast is a component of an endoplasmic reticulum-associated protein phosphatase complex and is thought to play a role in the synthesis of triacylglycerol. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

GeneCards Summary for CNEP1R1 Gene

CNEP1R1 (CTD Nuclear Envelope Phosphatase 1 Regulatory Subunit 1) is a Protein Coding gene.

UniProtKB/Swiss-Prot for CNEP1R1 Gene

  • Forms with the serine/threonine protein phosphatase CTDNEP1 an active complex which dephosphorylates and may activate LPIN1 and LPIN2. LPIN1 and LPIN2 are phosphatidate phosphatases that catalyze the conversion of phosphatidic acid to diacylglycerol and control the metabolism of fatty acids at differents levels. May indirectly modulate the lipid composition of nuclear and/or endoplasmic reticulum membranes and be required for proper nuclear membrane morphology and/or dynamics. May also indirectly regulate the production of lipid droplets and triacylglycerol.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CNEP1R1 Gene

Genomics for CNEP1R1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CNEP1R1 Gene

Start:
50,024,410 bp from pter
End:
50,037,088 bp from pter
Size:
12,679 bases
Orientation:
Plus strand

Genomic View for CNEP1R1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CNEP1R1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CNEP1R1 Gene

No data available for Regulatory Elements for CNEP1R1 Gene

Proteins for CNEP1R1 Gene

  • Protein details for CNEP1R1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N9A8-NEPR1_HUMAN
    Recommended name:
    Nuclear envelope phosphatase-regulatory subunit 1
    Protein Accession:
    Q8N9A8
    Secondary Accessions:
    • Q4G1A9
    • Q5H9V0
    • Q8NE06

    Protein attributes for CNEP1R1 Gene

    Size:
    125 amino acids
    Molecular mass:
    14267 Da
    Quaternary structure:
    • Interacts with CTDNEP1; the complex dephosphorylates LPIN1 and LPIN2.

    Alternative splice isoforms for CNEP1R1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CNEP1R1 Gene

Proteomics data for CNEP1R1 Gene at MOPED

Post-translational modifications for CNEP1R1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CNEP1R1 Gene

No data available for DME Specific Peptides for CNEP1R1 Gene

Domains for CNEP1R1 Gene

Protein Domains for CNEP1R1 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q8N9A8

UniProtKB/Swiss-Prot:

NEPR1_HUMAN :
  • Q8N9A8
Family:
  • Belongs to the CNEP1R1 family.
genes like me logo Genes that share domains with CNEP1R1: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for CNEP1R1 Gene

Function for CNEP1R1 Gene

Molecular function for CNEP1R1 Gene

UniProtKB/Swiss-Prot Function: Forms with the serine/threonine protein phosphatase CTDNEP1 an active complex which dephosphorylates and may activate LPIN1 and LPIN2. LPIN1 and LPIN2 are phosphatidate phosphatases that catalyze the conversion of phosphatidic acid to diacylglycerol and control the metabolism of fatty acids at differents levels. May indirectly modulate the lipid composition of nuclear and/or endoplasmic reticulum membranes and be required for proper nuclear membrane morphology and/or dynamics. May also indirectly regulate the production of lipid droplets and triacylglycerol.

Gene Ontology (GO) - Molecular Function for CNEP1R1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 22134922
genes like me logo Genes that share ontologies with CNEP1R1: view

Phenotypes for CNEP1R1 Gene

GenomeRNAi human phenotypes for CNEP1R1:
genes like me logo Genes that share phenotypes with CNEP1R1: view

Animal Model Products

CRISPR Products

miRNA for CNEP1R1 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CNEP1R1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for CNEP1R1 Gene

Localization for CNEP1R1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CNEP1R1 Gene

Nucleus membrane; Multi-pass membrane protein. Cytoplasm. Note=Filamentous pattern in the cytoplasm.

Gene Ontology (GO) - Cellular Components for CNEP1R1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005635 nuclear envelope TAS --
GO:0005737 cytoplasm IDA 22134922
GO:0016021 integral component of membrane IEA --
GO:0031965 nuclear membrane IDA 22134922
GO:0071595 Nem1-Spo7 phosphatase complex IDA 22134922
genes like me logo Genes that share ontologies with CNEP1R1: view

No data available for Subcellular locations from COMPARTMENTS for CNEP1R1 Gene

Pathways for CNEP1R1 Gene

SuperPathways for CNEP1R1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CNEP1R1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle TAS --
GO:0006629 lipid metabolic process IEA --
GO:0007077 mitotic nuclear envelope disassembly TAS --
GO:0010867 positive regulation of triglyceride biosynthetic process IGI 22134922
GO:0034504 protein localization to nucleus IDA 22134922
genes like me logo Genes that share ontologies with CNEP1R1: view

No data available for Pathways by source for CNEP1R1 Gene

Transcripts for CNEP1R1 Gene

Unigene Clusters for CNEP1R1 Gene

CTD nuclear envelope phosphatase 1 regulatory subunit 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CNEP1R1

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CNEP1R1 Gene

No ASD Table

Relevant External Links for CNEP1R1 Gene

GeneLoc Exon Structure for
CNEP1R1
ECgene alternative splicing isoforms for
CNEP1R1

Expression for CNEP1R1 Gene

mRNA expression in normal human tissues for CNEP1R1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CNEP1R1 Gene

SOURCE GeneReport for Unigene cluster for CNEP1R1 Gene Hs.59134

mRNA Expression by UniProt/SwissProt for CNEP1R1 Gene

Q8N9A8-NEPR1_HUMAN
Tissue specificity: Muscle specific with lower expression in other metabolic tissues.
genes like me logo Genes that share expressions with CNEP1R1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for CNEP1R1 Gene

Orthologs for CNEP1R1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CNEP1R1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CNEP1R1 35
  • 99.77 (n)
  • 100 (a)
TMEM188 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CNEP1R1 35
  • 93.87 (n)
  • 100 (a)
CNEP1R1 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CNEP1R1 35
  • 90.85 (n)
  • 92.25 (a)
CNEP1R1 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cnep1r1 35
  • 94.13 (n)
  • 100 (a)
Cnep1r1 16
Cnep1r1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cnep1r1 35
  • 92.53 (n)
  • 99.2 (a)
chicken
(Gallus gallus)
Aves CNEP1R1 35
  • 89.6 (n)
  • 98.4 (a)
CNEP1R1 36
  • 98 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CNEP1R1 36
  • 96 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia flj38101-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia cnep1r1 35
  • 82.13 (n)
  • 97.6 (a)
Str.1469 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10209 35
zebrafish
(Danio rerio)
Actinopterygii cnep1r1 35
  • 78.67 (n)
  • 94.4 (a)
cnep1r1 36
  • 94 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005430 35
  • 52.94 (n)
  • 60.5 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG41106 36
  • 32 (a)
OneToMany
CG8009 35
  • 57.39 (n)
  • 61.74 (a)
CG8009 36
  • 53 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea nepr-1 36
  • 32 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4360 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 70 (a)
OneToOne
Species with no ortholog for CNEP1R1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CNEP1R1 Gene

ENSEMBL:
Gene Tree for CNEP1R1 (if available)
TreeFam:
Gene Tree for CNEP1R1 (if available)

Paralogs for CNEP1R1 Gene

Selected SIMAP similar genes for CNEP1R1 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for CNEP1R1 Gene

genes like me logo Genes that share paralogs with CNEP1R1: view

No data available for Paralogs for CNEP1R1 Gene

Variants for CNEP1R1 Gene

Sequence variations from dbSNP and Humsavar for CNEP1R1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs1134181 -- 50,036,313(+) TTTTT(G/T)TATTT utr-variant-3-prime, nc-transcript-variant
rs1134182 -- 50,036,315(+) tttgt(A/T)ttttt utr-variant-3-prime, nc-transcript-variant
rs1362633 -- 50,028,661(-) AAGTG(C/T)TAAGA intron-variant
rs1477125 -- 50,027,038(-) TTTTA(C/T)TAGGT intron-variant
rs2041918 -- 50,035,401(-) GAAAA(C/G)ACAGA intron-variant

Relevant External Links for CNEP1R1 Gene

HapMap Linkage Disequilibrium report
CNEP1R1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CNEP1R1 Gene

Disorders for CNEP1R1 Gene

No disorders were found for CNEP1R1 Gene.

No data available for UniProtKB/Swiss-Prot for CNEP1R1 Gene

Publications for CNEP1R1 Gene

  1. Nuclear envelope phosphatase-regulatory subunit 1 (formerly TMEM188) is the metazoan SPO7 ortholog and functions in the lipin activation pathway. (PMID: 22134922) Han S. … Goodman J.M. (J. Biol. Chem. 2012) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PMID: 15342556) Suzuki Y. … Sugano S. (Genome Res. 2004) 3
  4. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for CNEP1R1 Gene

Sources for CNEP1R1 Gene

Back to Top

Content