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Aliases for CNDP2 Gene

Aliases for CNDP2 Gene

  • CNDP Dipeptidase 2 (Metallopeptidase M20 Family) 2 3
  • Peptidase A 2 3 4
  • PEPA 3 4 6
  • Glutamate Carboxypeptidase-Like Protein 1 3 4
  • Cytosolic Nonspecific Dipeptidase 2 3
  • CPGL 3 4
  • CN2 3 4
  • Cytosolic Non-Specific Dipeptidase 3
  • Epididymis Secretory Protein Li 13 3
  • CNDP Dipeptidase 2 4
  • EC 3.4.13.18 4
  • HEL-S-13 3
  • HsT2298 3

External Ids for CNDP2 Gene

Previous HGNC Symbols for CNDP2 Gene

  • PEPA

Previous GeneCards Identifiers for CNDP2 Gene

  • GC18P070313
  • GC18P070314
  • GC18P072163
  • GC18P068895

Summaries for CNDP2 Gene

Entrez Gene Summary for CNDP2 Gene

  • CNDP2, also known as tissue carnosinase and peptidase A (EC 3.4.13.18), is a nonspecific dipeptidase rather than a selective carnosinase (Teufel et al., 2003 [PubMed 12473676]).[supplied by OMIM, Mar 2008]

GeneCards Summary for CNDP2 Gene

CNDP2 (CNDP Dipeptidase 2 (Metallopeptidase M20 Family)) is a Protein Coding gene. Diseases associated with CNDP2 include edwards syndrome. Among its related pathways are Metabolism and Arginine and proline metabolism. GO annotations related to this gene include metallopeptidase activity and dipeptidase activity. An important paralog of this gene is CNDP1.

UniProtKB/Swiss-Prot for CNDP2 Gene

  • Hydrolyzes a variety of dipeptides including L-carnosine but has a strong preference for Cys-Gly. Isoform 2 may be play a role as tumor suppressor in hepatocellular carcinoma (HCC) cells.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CNDP2 Gene

Genomics for CNDP2 Gene

Regulatory Elements for CNDP2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CNDP2 Gene

Start:
74,495,816 bp from pter
End:
74,523,454 bp from pter
Size:
27,639 bases
Orientation:
Plus strand

Genomic View for CNDP2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CNDP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CNDP2 Gene

Proteins for CNDP2 Gene

  • Protein details for CNDP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96KP4-CNDP2_HUMAN
    Recommended name:
    Cytosolic non-specific dipeptidase
    Protein Accession:
    Q96KP4
    Secondary Accessions:
    • B3KUG4
    • Q8WY59
    • Q9BQ94
    • Q9NVB4

    Protein attributes for CNDP2 Gene

    Size:
    475 amino acids
    Molecular mass:
    52878 Da
    Cofactor:
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Note=Binds 2 manganese ions per subunit.;
    Quaternary structure:
    • Homodimer.

    Alternative splice isoforms for CNDP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CNDP2 Gene

Proteomics data for CNDP2 Gene at MOPED

Post-translational modifications for CNDP2 Gene

  • Ubiquitination at Lys24, Lys383, and Lys402
  • Modification sites at PhosphoSitePlus

Antibody Products

  • R&D Systems Antibodies for CNDP2 (Cytosol Nonspecific Dipeptidase (CNDP2)/CPGL)
  • Santa Cruz Biotechnology (SCBT) Antibodies for CNDP2

Protein Products

No data available for DME Specific Peptides for CNDP2 Gene

Domains for CNDP2 Gene

Gene Families for CNDP2 Gene

Suggested Antigen Peptide Sequences for CNDP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96KP4

UniProtKB/Swiss-Prot:

CNDP2_HUMAN :
  • Q96KP4
Family:
  • Belongs to the peptidase M20A family.
genes like me logo Genes that share domains with CNDP2: view

Function for CNDP2 Gene

Molecular function for CNDP2 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=1.04 mM for Ser-Gln (at pH 7.5 and in the presence of 0.1 mM manganese ions) {ECO:0000269 PubMed:12473676, ECO:0000269 PubMed:19346245}; KM=0.6 mM for Cys-Gly (at pH 8.0 and in the presence of 50 uM manganese ions) {ECO:0000269 PubMed:12473676, ECO:0000269 PubMed:19346245}; KM=15 mM for carnosine (at pH 9.5 and in the presence of 0.1 mM manganese ions) {ECO:0000269 PubMed:12473676, ECO:0000269 PubMed:19346245};
UniProtKB/Swiss-Prot CatalyticActivity:
Hydrolysis of dipeptides, preferentially hydrophobic dipeptides including prolyl amino acids.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by p-hydroxymercurybenzoate. The inhibitory concentration 50% (IC(50)) is 13 uM. Inhibited by bestatin. The inhibitory concentration 50% (IC(50)) is 7 nM at pH 9.5.
UniProtKB/Swiss-Prot Function:
Hydrolyzes a variety of dipeptides including L-carnosine but has a strong preference for Cys-Gly. Isoform 2 may be play a role as tumor suppressor in hepatocellular carcinoma (HCC) cells.

Enzyme Numbers (IUBMB) for CNDP2 Gene

Gene Ontology (GO) - Molecular Function for CNDP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004180 carboxypeptidase activity TAS --
GO:0008233 peptidase activity --
GO:0008237 metallopeptidase activity IEA --
GO:0016787 hydrolase activity --
GO:0016805 dipeptidase activity IEA --
genes like me logo Genes that share ontologies with CNDP2: view

Animal Model Products

miRNA for CNDP2 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CNDP2

In Situ Assay Products

Flow Cytometry Products

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for CNDP2 Gene

Localization for CNDP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CNDP2 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CNDP2 Gene COMPARTMENTS Subcellular localization image for CNDP2 gene
Compartment Confidence
cytosol 4
cytoskeleton 1
nucleus 1

Gene Ontology (GO) - Cellular Components for CNDP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with CNDP2: view

Pathways for CNDP2 Gene

genes like me logo Genes that share pathways with CNDP2: view

Gene Ontology (GO) - Biological Process for CNDP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000096 sulfur amino acid metabolic process TAS --
GO:0006508 proteolysis IEA --
GO:0006750 glutathione biosynthetic process TAS --
GO:0006805 xenobiotic metabolic process TAS --
GO:0008152 metabolic process --
genes like me logo Genes that share ontologies with CNDP2: view

Compounds for CNDP2 Gene

(1) Novoseek inferred chemical compound relationships for CNDP2 Gene

Compound -log(P) Hits PubMed IDs
thimet 77.6 1
genes like me logo Genes that share compounds with CNDP2: view

Transcripts for CNDP2 Gene

Unigene Clusters for CNDP2 Gene

CNDP dipeptidase 2 (metallopeptidase M20 family):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CNDP2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CNDP2 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c · 3d ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e · 6f · 6g · 6h ^ 7 ^ 8a · 8b · 8c · 8d ^ 9a · 9b ·
SP1: - - - - - - - - -
SP2: - - -
SP3: - - - - - - - - - - - - -
SP4: - - - - - - -
SP5: - - - - - - - - - - - -
SP6: -
SP7:
SP8: - - - - - - - - - - - - - - - - - -
SP9: - - - - - - - - - - - -
SP10: - - - - - - - -
SP11: -
SP12: - - - - - - - - - - -
SP13: - - - - - - - - - - -
SP14: -
SP15: - - -
SP16: - - - -
SP17:
SP18: - - - - - - - - - - - - - - - - - - -
SP19: - - - - - - - - - - -
SP20: - - -
SP21: -
SP22:
SP23:
SP24:
SP25:
SP26:
SP27: -

ExUns: 9c ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b · 13c · 13d · 13e ^ 14a · 14b · 14c · 14d ^ 15 ^ 16a · 16b · 16c ^ 17a · 17b · 17c · 17d ^ 18a · 18b ^ 19a ·
SP1: - - - - -
SP2: - - - - - - - - - - -
SP3:
SP4:
SP5:
SP6: - - -
SP7: - -
SP8:
SP9:
SP10:
SP11:
SP12:
SP13: - - -
SP14: - - - -
SP15: - - - - - -
SP16: -
SP17: - -
SP18:
SP19:
SP20:
SP21: - - - - - - - - - - - - - -
SP22:
SP23: - - - - - - -
SP24: - - -
SP25: -
SP26: -
SP27:

ExUns: 19b ^ 20 ^ 21
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:
SP23:
SP24:
SP25:
SP26:
SP27:

Relevant External Links for CNDP2 Gene

GeneLoc Exon Structure for
CNDP2
ECgene alternative splicing isoforms for
CNDP2

Expression for CNDP2 Gene

mRNA expression in normal human tissues for CNDP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CNDP2 Gene

This gene is overexpressed in Kidney - Cortex (4.9).

Protein differential expression in normal tissues for CNDP2 Gene

This gene is overexpressed in Spleen (7.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CNDP2 Gene

SOURCE GeneReport for Unigene cluster for CNDP2 Gene Hs.149185

mRNA Expression by UniProt/SwissProt for CNDP2 Gene

Q96KP4-CNDP2_HUMAN
Tissue specificity: Isoform 1 is ubiquitously expressed with higher levels in kidney and liver (at protein level). Isoform 2 is expressed in fetal tissues, it is only expressed in adult liver and placental tissues.
genes like me logo Genes that share expressions with CNDP2: view

Expression partners for CNDP2 Gene

In Situ Assay Products

Orthologs for CNDP2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CNDP2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CNDP2 35
  • 84.98 (n)
  • 91.37 (a)
CNDP2 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CNDP2 35
  • 86.82 (n)
  • 91.75 (a)
CNDP2 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cndp2 35
  • 84.91 (n)
  • 91.16 (a)
Cndp2 16
Cndp2 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CNDP2 35
  • 98.95 (n)
  • 98.95 (a)
CNDP2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cndp2 35
  • 84.49 (n)
  • 90.32 (a)
oppossum
(Monodelphis domestica)
Mammalia CNDP2 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 84 (a)
OneToMany
-- 36
  • 84 (a)
OneToMany
chicken
(Gallus gallus)
Aves CNDP2 35
  • 75.37 (n)
  • 84.63 (a)
CNDP2 36
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CNDP2 36
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cndp2 35
  • 73.77 (n)
  • 81.22 (a)
MGC75655 35
African clawed frog
(Xenopus laevis)
Amphibia cn2-prov 35
zebrafish
(Danio rerio)
Actinopterygii cndp2 35
  • 69.91 (n)
  • 75.48 (a)
wufd20d11 35
cndp2 36
  • 78 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11239 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007619 35
  • 61.06 (n)
  • 63.62 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG17337 35
  • 59.32 (n)
  • 62.92 (a)
CG17337 36
  • 62 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y71H2AM.11 35
  • 54.96 (n)
  • 56.81 (a)
pes-9 36
  • 57 (a)
ManyToMany
Y71H2AM.11 36
  • 57 (a)
ManyToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR252C 35
  • 57.56 (n)
  • 52.69 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A01001g 35
  • 54.86 (n)
  • 53.78 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DUG1 35
  • 54.96 (n)
  • 52.13 (a)
DUG1 36
  • 51 (a)
OneToMany
DUG1 38
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4756 35
bread mold
(Neurospora crassa)
Ascomycetes NCU07153 35
  • 57.01 (n)
  • 52.79 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC1198.08 35
  • 53.76 (n)
  • 52.55 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3123 36
  • 71 (a)
OneToOne
Species with no ortholog for CNDP2:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CNDP2 Gene

ENSEMBL:
Gene Tree for CNDP2 (if available)
TreeFam:
Gene Tree for CNDP2 (if available)

Paralogs for CNDP2 Gene

Paralogs for CNDP2 Gene

genes like me logo Genes that share paralogs with CNDP2: view

Variants for CNDP2 Gene

Sequence variations from dbSNP and Humsavar for CNDP2 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type MAF
rs7577 -- 74,521,112(-) GTGTC(A/G)TGTTT utr-variant-3-prime
rs15165 -- 74,521,016(-) AAAAT(A/G)CCAGT utr-variant-3-prime
rs733062 -- 74,518,824(-) GCCCG(C/T)GTTCA intron-variant
rs734559 -- 74,512,344(+) TTTGG(A/G)AAATT intron-variant
rs735076 -- 74,518,453(+) CAAAT(A/G)CAAGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CNDP2 Gene

Variant ID Type Subtype PubMed ID
nsv909916 CNV Gain 21882294
dgv3467n71 CNV Loss 21882294
esv2717347 CNV Deletion 23290073
esv2717348 CNV Deletion 23290073
esv1617659 CNV Insertion 17803354
nsv909919 CNV Gain 21882294

Relevant External Links for CNDP2 Gene

HapMap Linkage Disequilibrium report
CNDP2
Human Gene Mutation Database (HGMD)
CNDP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CNDP2 Gene

Disorders for CNDP2 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for CNDP2 Gene in MalaCards »

(1) Diseases for CNDP2 Gene including...

(1) University of Copenhagen DISEASES for CNDP2 Gene

(1) Novoseek inferred disease relationships for CNDP2 Gene

Disease -log(P) Hits PubMed IDs
diabetic nephropathies 49.8 6

Relevant External Links for CNDP2

Genetic Association Database (GAD)
CNDP2
Human Genome Epidemiology (HuGE) Navigator
CNDP2
genes like me logo Genes that share disorders with CNDP2: view

No data available for OMIM , UniProtKB/Swiss-Prot and Genatlas for CNDP2 Gene

Publications for CNDP2 Gene

  1. Sequence identification and characterization of human carnosinase and a closely related non-specific dipeptidase. (PMID: 12473676) Teufel M. … Smirnova T. (J. Biol. Chem. 2003) 2 3 4 23
  2. Exclusion of polymorphisms in carnosinase genes (CNDP1 and CNDP2) as a cause of diabetic nephropathy in type 1 diabetes: results of large case-control and follow-up studies. (PMID: 18753673) Wanic K. … Krolewski A.S. (Diabetes 2008) 3 23 48
  3. The influence of carnosinase gene polymorphisms on diabetic nephropathy risk in African-Americans. (PMID: 19373489) McDonough C.W. … Bowden D.W. (Hum. Genet. 2009) 3 23 48
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for CNDP2 Gene

Sources for CNDP2 Gene

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