Aliases for CNDP2 Gene
External Ids for CNDP2 Gene
Previous HGNC Symbols for CNDP2 Gene
Previous GeneCards Identifiers for CNDP2 Gene
CNDP2, also known as tissue carnosinase and peptidase A (EC 22.214.171.124), is a nonspecific dipeptidase rather than a selective carnosinase (Teufel et al., 2003 [PubMed 12473676]).[supplied by OMIM, Mar 2008]
GeneCards Summary for CNDP2 Gene
CNDP2 (CNDP Dipeptidase 2 (Metallopeptidase M20 Family)) is a Protein Coding gene. Diseases associated with CNDP2 include Pyriform Sinus Cancer and Hypopharynx Cancer. Among its related pathways are Histidine metabolism and Phase II conjugation. GO annotations related to this gene include hydrolase activity and metallopeptidase activity. An important paralog of this gene is CNDP1.
UniProtKB/Swiss-Prot for CNDP2 Gene
Hydrolyzes a variety of dipeptides including L-carnosine but has a strong preference for Cys-Gly (PubMed:19346245). Acts as a functional tumor suppressor in gastric cancer via activation of the mitogen-activated protein kinase (MAPK) pathway. An elevated level of CNDP2 activates the p38 and JNK MAPK pathways to induce cell apoptosis, and a lower level of CNDP2 activates the ERK MAPK pathway to promote cell proliferation (PubMed:24395568). Isoform 2 may play a role as tumor suppressor in hepatocellular carcinoma (HCC) cells (PubMed:17121880). Catalyzes the production of N-lactoyl-amino acids from lactate and amino acids by reverse proteolysis (PubMed:25964343).