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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CNDP2 Gene

protein-coding   GIFtS: 64
GCID: GC18P072163

CNDP Dipeptidase 2 (Metallopeptidase M20 Family)

(Previous name: peptidase A)
(Previous symbol: PEPA)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
CNDP Dipeptidase 2 (Metallopeptidase M20 Family)1 2     Cytosolic Nonspecific Dipeptidase (EC 3.4.13.18)1
PEPA1 2 3 5     HsT22982
Peptidase A1 2 3     Cytosolic Non-Specific Dipeptidase2
Glutamate Carboxypeptidase-Like Protein 12 3     Cytosolic Nonspecific Dipeptidase2
CN22 3     EC 3.4.13.183
CPGL2 3     CNDP Dipeptidase 23

External Ids:    HGNC: 244371   Entrez Gene: 557482   Ensembl: ENSG000001333137   OMIM: 1698005   UniProtKB: Q96KP43   

Export aliases for CNDP2 gene to outside databases

Previous GC identifers: GC18P070313 GC18P070314 GC18P068895


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CNDP2 Gene:
CNDP2, also known as tissue carnosinase and peptidase A (EC 3.4.13.18), is a nonspecific dipeptidase rather than a
selective carnosinase (Teufel et al., 2003 (PubMed 12473676)).(supplied by OMIM, Mar 2008)

GeneCards Summary for CNDP2 Gene: 
CNDP2 (CNDP dipeptidase 2 (metallopeptidase M20 family)) is a protein-coding gene. Diseases associated with CNDP2 include edwards syndrome, and crigler-najjar syndrome, and among its related super-pathways are Metabolic pathways and gamma-glutamyl cycle. GO annotations related to this gene include metallopeptidase activity and dipeptidase activity. An important paralog of this gene is CNDP1.

UniProtKB/Swiss-Prot: CNDP2_HUMAN, Q96KP4
Function: Hydrolyzes a variety of dipeptides including L-carnosine but has a strong preference for Cys-Gly.
Isoform 2 may be play a role as tumor suppressor in hepatocellular carcinoma (HCC) cells




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000018.9  NT_025028.14  NC_018929.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CNDP2 gene promoter:
         GR   Elk-1   POU2F1   POU2F1a   POU2F1b   GR-alpha   POU2F1c   GCNF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CNDP2 promoter sequence
   Search SABiosciences Chromatin IP Primers for CNDP2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CNDP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q22.3   Ensembl cytogenetic band:  18q22.3   HGNC cytogenetic band: 18q22.3

CNDP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CNDP2 gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18P072163:  view genomic region     (about GC identifiers)

Start:
72,163,051 bp from pter      End:
72,190,689 bp from pter
Size:
27,639 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CNDP2_HUMAN, Q96KP4 (See protein sequence)
Recommended Name: Cytosolic non-specific dipeptidase  
Size: 475 amino acids; 52878 Da
Cofactor: Binds 2 manganese ions per subunit (By similarity)
Subunit: Homodimer
Subcellular location: Cytoplasm
Secondary accessions: B3KUG4 Q8WY59 Q9BQ94 Q9NVB4
Alternative splicing: 2 isoforms:  Q96KP4-1   Q96KP4-2   

Explore the universe of human proteins at neXtProt for CNDP2: NX_Q96KP4

Explore proteomics data for CNDP2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96KP4

  • CNDP2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CNDP2 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001161971.1  NP_060705.2  

    ENSEMBL proteins: 
     ENSP00000464151   ENSP00000325548   ENSP00000464214   ENSP00000462311   ENSP00000463314  
     ENSP00000464319   ENSP00000463702   ENSP00000463816   ENSP00000464122   ENSP00000464014  
     ENSP00000462673   ENSP00000462626   ENSP00000463182   ENSP00000463222   ENSP00000325756  
     ENSP00000461941   ENSP00000462034  
    Reactome Protein details: Q96KP4
    Human Recombinant Protein Products for CNDP2: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for CNDP2 (Cytosol Nonspecific Dipeptidase (CNDP2)/CPGL)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for CNDP2
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    Novus Biologicals CNDP2 Proteins
    Novus Biologicals CNDP2 Lysates
    Sino Biological Recombinant Protein for CNDP2
    Sino Biological Cell Lysate for CNDP2 
    ProSpec Recombinant Protein for CNDP2
    Cloud-Clone Corp. Proteins for CNDP2 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--

    CNDP2 for ontologies           About GeneDecksing



    CNDP2 Antibody Products: 
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    Abcam antibodies for CNDP2
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IUPHAR Guide to PHARMACOLOGY protein family classification: Carnosine dipeptidase 2 
    Metallocarboxypeptidases

    4 InterPro protein domains:
     IPR017153 GSH_degradosome_DUG1
     IPR011650 Peptidase_M20_dimer
     IPR001261 ArgE/DapE_CS
     IPR002933 Peptidase_M20

    Graphical View of Domain Structure for InterPro Entry Q96KP4

    ProtoNet protein and cluster: Q96KP4

    2 Blocks protein domains:
    IPB001261 ArgE/dapE/ACY1/CPG2/yscS
    IPB011650 Peptidase dimerisation


    UniProtKB/Swiss-Prot: CNDP2_HUMAN, Q96KP4
    Similarity: Belongs to the peptidase M20A family


    CNDP2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CNDP2_HUMAN, Q96KP4
    Function: Hydrolyzes a variety of dipeptides including L-carnosine but has a strong preference for Cys-Gly.
    Isoform 2 may be play a role as tumor suppressor in hepatocellular carcinoma (HCC) cells
    Catalytic activity: Hydrolysis of dipeptides, preferentially hydrophobic dipeptides including prolyl amino acids
    Enzyme regulation: Inhibited by p-hydroxymercurybenzoate. The inhibitory concentration 50% (IC(50)) is 13 uM.
    Inhibited by bestatin. The inhibitory concentration 50% (IC(50)) is 7 nM at pH 9.5
    Biophysicochemical properties: Kinetic parameters: KM=1.04 mM for Ser-Gln (at pH 7.5 and in the presence of 0.1 mM
    manganese ions); KM=0.6 mM for Cys-Gly (at pH 8.0 and in the presence of 50 uM manganese ions); KM=15 mM for
    carnosine (at pH 9.5 and in the presence of 0.1 mM manganese ions);

         Enzyme Number (IUBMB): EC 3.4.13.181

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004180carboxypeptidase activity TAS--
    GO:0008233peptidase activity ----
    GO:0008237metallopeptidase activity IEA--
    GO:0016787hydrolase activity ----
    GO:0016805dipeptidase activity IEA--
         
    CNDP2 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI phenotypic allele for Cndp2 (no phenotypes)

    CNDP2 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for CNDP2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CNDP2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CNDP2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CNDP2 

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    1 QIAGEN miScript miRNA Assays for microRNA that regulate CNDP2:
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    SwitchGear 3'UTR luciferase reporter plasmidCNDP2 3' UTR sequence
    Inhib. RNA
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    Sino Biological Human cDNA Clone for CNDP2
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CNDP2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CNDP2 About   (see all 9)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Metabolism
    Metabolism0.40
    Metabolic pathways0.40
    2Glutathione synthesis and recycling
    gamma-glutamyl cycle0.38
    Glutathione synthesis and recycling0.38
    3Biological oxidations
    Biological oxidations0.55
    Phase II conjugation0.55
    4Glutathione metabolism
    Glutathione conjugation0.60
    5Cysteine and methionine metabolism
    Sulfur amino acid metabolism0.37

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for CNDP2
        gamma-glutamyl cycle


    5/7        Reactome Pathways for CNDP2 (see all 7)
        Glutathione synthesis and recycling
    Metabolism
    Sulfur amino acid metabolism
    Biological oxidations
    Glutathione conjugation


    4         Kegg Pathways  (Kegg details for CNDP2):
        Arginine and proline metabolism
    Histidine metabolism
    beta-Alanine metabolism
    Metabolic pathways


    CNDP2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CNDP2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    5/40 Interacting proteins for CNDP2 (Q96KP41, 3 ENSP000003255484) via UniProtKB, MINT, STRING, and/or I2D (see all 40)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NDRG1Q925971, 3, ENSP000003199774EBI-1190734,EBI-716486 I2D: score=1 STRING: ENSP00000319977
    HSPD1P108093, ENSP000003400194I2D: score=1 STRING: ENSP00000340019
    CSE1LP550603, ENSP000002629824I2D: score=2 STRING: ENSP00000262982
    ARFGEF1Q9Y6D63I2D: score=4 
    RHOAP615863I2D: score=4 
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000096sulfur amino acid metabolic process TAS--
    GO:0006508proteolysis IEA--
    GO:0006750glutathione biosynthetic process TAS--
    GO:0006805xenobiotic metabolic process TAS--
    GO:0008152metabolic process ----

    CNDP2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CNDP2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CNDP2

    1 Novoseek inferred chemical compound relationship for CNDP2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    thimet 77.6 1 17277461 (1)

    Search CenterWatch for drugs/clinical trials and news about CNDP2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CNDP2 gene (2 alternative transcripts): 
    NM_001168499.1  NM_018235.2  

    Unigene Cluster for CNDP2:

    CNDP dipeptidase 2 (metallopeptidase M20 family)
    Hs.149185  [show with all ESTs]
    Unigene Representative Sequence: NM_018235
    18/29 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 29):
    ENST00000581272 ENST00000324262(uc021ulm.1 uc002llm.2) ENST00000580672
    ENST00000583399 ENST00000579847 ENST00000583203 ENST00000582260 ENST00000581513
    ENST00000580229 ENST00000577600 ENST00000579583 ENST00000584613 ENST00000583216
    ENST00000581912 ENST00000582589 ENST00000583785 ENST00000324301(uc002lln.2)
    ENST00000582620
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate CNDP2:
    hsa-miR-4251
    SwitchGear 3'UTR luciferase reporter plasmidCNDP2 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AF258592.1 AJ347717.1 AK001262.1 AK001692.1 AK001983.1 AK097155.1 AK298309.1 AK300904.1 
    BC001375.2 BC003176.1 

    24/39 DOTS entries (see all 39):

    DT.418336  DT.100845562  DT.100845556  DT.100845566  DT.91933901  DT.100845559  DT.100845571  DT.91769983 
    DT.121097376  DT.413016  DT.92410309  DT.121097402  DT.100034722  DT.121097381  DT.121097408  DT.87079100 
    DT.97760065  DT.100845573  DT.121097360  DT.91769989  DT.91769992  DT.100834923  DT.121097371  DT.121097422 

    24/667 AceView cDNA sequences (see all 667):

    BU192922 BM927649 CB993588 CB993805 BG171680 BU931553 BQ053384 AL045131 
    BU177134 BU160527 BG697206 BQ057102 AL544678 BU944083 BQ958682 AA688325 
    AA318146 AA406015 BU184087 CR593876 AI880173 CB993636 CB156243 BQ071435 

    GeneLoc Exon Structure

    5/27 Alternative Splicing Database (ASD) splice patterns (SP) for CNDP2 (see all 27)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c · 3d ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e · 6f · 6g · 6h ^ 7 ^ 8a · 8b · 8c · 8d ^ 9a · 9b ·
    SP1:                                -     -     -     -     -     -     -     -                                               -                                 
    SP2:                                                                                                                          -                       -     -   
    SP3:                                -           -     -     -     -     -     -     -     -     -     -     -                 -                                 
    SP4:                                            -     -     -     -     -     -                                               -                                 
    SP5:                                            -     -     -     -     -     -     -     -     -     -     -                 -                                 

    ExUns: 9c ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b · 13c · 13d · 13e ^ 14a · 14b · 14c · 14d ^ 15 ^ 16a · 16b · 16c ^ 17a · 17b · 17c · 17d ^ 18a · 18b ^ 19a ·
    SP1:                                                                                -     -     -                                         -           -         
    SP2:  -     -     -     -     -     -                                               -     -     -                                         -           -         
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 19b ^ 20 ^ 21
    SP1:                  
    SP2:                  
    SP3:                  
    SP4:                  
    SP5:                  


    ECgene alternative splicing isoforms for CNDP2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CNDP2 expression in normal human tissues (normalized intensities)      CNDP2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACACCTCTAA
    CNDP2 Expression
    About this image


    CNDP2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Trophoblast (Extraembryonic Tissues)
             Mural Trophectoderm Cells Mural Trophectoderm
     
     Gut Tube (Gastrointestinal Tract)
             Definitive endoderm-like cells ( A scalable, suspension protocol for derivation of...
     
     Ear (Sensory Organs)
             sensory organ/ear   

    See CNDP2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CNDP2

    SOURCE GeneReport for Unigene cluster: Hs.149185

    UniProtKB/Swiss-Prot: CNDP2_HUMAN, Q96KP4
    Tissue specificity: Isoform 1 is ubiquitously expressed with higher levels in kidney and liver (at protein level).
    Isoform 2 is expressed in fetal tissues, it is only expressed in adult liver and placental tissues

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for CNDP2 gene from 8/23 species (see all 23)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cndp21 , 5 CNDP dipeptidase 2 (metallopeptidase M20 family)1, 5 84.91(n)1
    91.16(a)1
      18 (57.53 cM)5
    660541  NM_023149.21  NP_075638.21 
     846674705 
    chicken
    (Gallus gallus)
    Aves CNDP21 CNDP dipeptidase 2 (metallopeptidase M20 family) 75.37(n)
    84.63(a)
      421013  NM_001006385.1  NP_001006385.1 
    lizard
    (Anolis carolinensis)
    Reptilia CNDP26
    Uncharacterized protein
    84(a)
    1 ↔ 1
    4(49192996-49228230)
    African clawed frog
    (Xenopus laevis)
    Amphibia cn2-prov2 cytosolic nonspecific dipeptidase (EC 3.4.13.18) 76.46(n)    BC056069.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufd20d112 Danio rerio cytosolic nonspecific dipeptidase (CN2) more 76.3(n)    AY391414.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG173371 CG17337 59.5(n)
    63.19(a)
      35507  NM_136337.2  NP_610181.2 
    worm
    (Caenorhabditis elegans)
    Secernentea Y71H2AM.111 Protein Y71H2AM.11 54.96(n)
    56.81(a)
      175387  NM_065205.5  NP_497606.4 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes DUG1(YFR044C)4
    DUG11
    Cys-Gly metallo-di-peptidase; forms a complex with more4
    Dug1p1
    54.96(n)1
    52.13(a)1
      6(241437-239992)4
    8506051, 4  NP_116702.11, 4 


    ENSEMBL Gene Tree for CNDP2 (if available)
    TreeFam Gene Tree for CNDP2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CNDP2 gene
    CNDP12  
    2 SIMAP similar genes for CNDP2 using alignment to 16 protein entries:     CNDP2_HUMAN (see all proteins):
    FLJ00064    CNDP1

    CNDP2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/850 SNPs in CNDP2 are shown (see all 850)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 18 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1117417471,2
    C,F--72161543(+) TTAAGA/GGTAAA 1 -- us2k12Minor allele frequency- G:0.33CSA 3
    rs773357811,2
    F--72161597(+) AGAAAC/TATGTT 1 -- us2k10--------
    rs80841151,2
    C,F--72161600(+) aacatG/Attcac 1 -- us2k16Minor allele frequency- A:0.17WA NA CSA 246
    rs1492461331,2
    C--72161785(+) TTTGC-/TATATAC 1 -- us2k10--------
    rs2019485411,2
    --72161790(+) TATAT-/ACATATG 1 -- us2k10--------
    rs106331651,2
    C--72161794(+) ACATA-/TGtgtgt 1 -- us2k10--------
    rs1448734991,2
    C--72161821(+) TTTTT-/TAACCA 1 -- us2k10--------
    rs1903673771,2
    --72161905(+) TAGATA/TTGATT 1 -- us2k10--------
    rs1813498751,2
    --72161907(+) GATATC/GATTAA 1 -- us2k10--------
    rs1426943531,2
    --72161970(+) ATATAC/GTTTTT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CNDP2 (72163051 - 72190689 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for CNDP2:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2717348CNV Deletion23290073
    esv2717347CNV Deletion23290073
    esv1617659CNV Insertion17803354
    dgv3467n71CNV Loss21882294
    nsv909919CNV Gain21882294
    nsv909916CNV Gain21882294


    Human Gene Mutation Database (HGMD): CNDP2
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 169800    OMIM disorders: --

    17 diseases for CNDP2:    About MalaCards
    edwards syndrome    crigler-najjar syndrome    gilbert syndrome    neuritis
    type 1 diabetes    type 1 diabetes mellitus    diabetes mellitus    pneumonia
    tuberculosis    hepatocellular carcinoma    rheumatoid arthritis    arthritis
    parkinson's disease    pancreatic cancer    prostate cancer    prostatitis
    pancreatitis

    1 disease from the University of Copenhagen DISEASES database for CNDP2:
    Edwards syndrome

    CNDP2 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    1 Novoseek inferred disease relationship for CNDP2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    diabetic nephropathies 49.8 4 18753673 (2), 19373489 (2), 19033401 (1), 19033402 (1)

    Genetic Association Database (GAD): CNDP2
    Human Genome Epidemiology (HuGE) Navigator: CNDP2 (3 documents)

    Export disorders for CNDP2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CNDP2 gene, integrated from 9 sources (see all 40):
    (articles sorted by number of sources associating them with CNDP2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Sequence identification and characterization of human carnosinase and a closely related non-specific dipeptidase. (PubMed id 12473676)1, 2, 3, 9 Teufel M....Smirnova T. (2003)
    2. The influence of carnosinase gene polymorphisms on diabetic nephropathy risk in African-Americans. (PubMed id 19373489)1, 4, 9 McDonough C.W....Bowden D.W. (2009)
    3. Exclusion of polymorphisms in carnosinase genes (CNDP1 and CNDP2) as a cause of diabetic nephropathy in type 1 diabetes: results of large case-control and follow-up studies. (PubMed id 18753673)1, 4, 9 Wanic K....Krolewski A.S. (2008)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Genome-wide meta-analyses of multiancestry cohorts ide ntify multiple new susceptibility loci for refractive error and myopia. (PubMed id 23396134)1 Verhoeven V.J....Hammond C.J. (2013)
    7. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    8. Proteomic profiling of the substantia nigra demonstrat es CNDP2 overexpression in Parkinson's disease. (PubMed id 22410244)1 Licker V....Burkhard P.R. (2012)
    9. A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
    10. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55748 HGNC: 24437 AceView: CNDP2 Ensembl:ENSG00000133313 euGenes: HUgn55748
    ECgene: CNDP2 Kegg: 55748 H-InvDB: CNDP2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CNDP2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CNDP2 gene:
    Search GeneIP for patents involving CNDP2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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