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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CNDP2 Gene

protein-coding GIFtS: 55
GCID: GC18P072163

CNDP dipeptidase 2 (metallopeptidase M20 family)

(Previous name: peptidase A )
(Previous symbol: PEPA)

Explore 16 diseases affiliated with
CNDP2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
CNDP Dipeptidase 2 (Metallopeptidase M20 Family)¹ ²		Glutamate Carboxypeptidase-Like Protein 1² ³
PEPA¹ ² ³ ⁵		FLJ10830¹
Peptidase A¹ ² ³		Cytosolic Non-Specific Dipeptidase²
CN2¹ ² ³		Cytosolic Nonspecific Dipeptidase²
CPGL¹ ² ³		EC 3.4.13.18³
HsT2298¹ ²		CNDP Dipeptidase 2³

External Ids:	HGNC: 24437¹	Entrez Gene: 55748²	Ensembl: ENSG00000133313⁷	OMIM: 169800⁵	UniProtKB: Q96KP4³

Export aliases for CNDP2 gene to outside databases

Previous GC identifers: GC18P070313 GC18P070314 GC18P068895

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CNDP2:

CNDP2, also known as tissue carnosinase and peptidase A (EC 3.4.13.18), is a nonspecific dipeptidase rather than a

selective carnosinase (Teufel et al., 2003 (PubMed 12473676)).(supplied by OMIM, Mar 2008)

UniProtKB/Swiss-Prot: CNDP2_HUMAN, Q96KP4

Function: Hydrolyzes a variety of dipeptides including L-carnosine but has a strong preference for Cys-Gly. Isoform 2

may be play a role as tumor suppressor in hepatocellular carcinoma (HCC) cells

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000018.9 NC_018929.1 NT_025028.14

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CNDP2 gene promoter:
GR Elk-1 POU2F1 POU2F1a POU2F1b GR-alpha POU2F1c GCNF-2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CNDP2 promoter sequence

Search SABiosciences Chromatin IP Primers for CNDP2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CNDP2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q22.3 Ensembl cytogenetic band: 18q22.3 HGNC cytogenetic band: 18q22.3

CNDP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CNDP2 gene location

GeneLoc information about chromosome 18 GeneLoc Exon Structure

GeneLoc location for GC18P072163: view genomic region (about GC identifiers)

Start:	72,163,051 bp from pter	End:	72,190,689 bp from pter
Size:	27,639 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CNDP2_HUMAN, Q96KP4 (See protein sequence)

Recommended Name: Cytosolic non-specific dipeptidase

Size: 475 amino acids; 52878 Da

Cofactor: Binds 2 manganese ions per subunit (By similarity)

Subunit: Homodimer

Subcellular location: Cytoplasm

Secondary accessions: B3KUG4 Q8WY59 Q9BQ94 Q9NVB4

Alternative splicing: 2 isoforms: Q96KP4-1 Q96KP4-2

Explore the universe of human proteins at neXtProt for CNDP2: NX_Q96KP4

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q96KP4

CNDP2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001161971.1 NP_060705.2

ENSEMBL proteins:

ENSP00000464151 ENSP00000325548 ENSP00000464214 ENSP00000462311 ENSP00000463314

ENSP00000464319 ENSP00000463702 ENSP00000463816 ENSP00000464122 ENSP00000464014

ENSP00000462673 ENSP00000462626 ENSP00000463182 ENSP00000463222 ENSP00000325756

ENSP00000461941 ENSP00000462034

Reactome Protein details: Q96KP4
Human Recombinant Protein Products:

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	Novus Biologicals CNDP2 Proteins Novus Biologicals CNDP2 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for CNDP2

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005829	cytosol	TAS	--

CNDP2 for ontologies About GeneDecksing

CNDP2 Antibody Products:

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Assay Products for CNDP2:

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	Uscn ELISAs and CLIAs for CNDP2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CNDP2 for domains About GeneDecksing

4 InterPro domains/families:

IPR017153 GSH_degradosome_DUG1

IPR011650 Peptidase_M20_dimer

IPR001261 ArgE/DapE_CS

IPR002933 Peptidase_M20

Graphical View of Domain Structure for InterPro Entry Q96KP4

ProtoNet protein and cluster: Q96KP4

2 Blocks protein families:

IPB001261 ArgE/dapE/ACY1/CPG2/yscS

IPB011650 Peptidase dimerisation

UniProtKB/Swiss-Prot: CNDP2_HUMAN, Q96KP4

Similarity: Belongs to the peptidase M20A family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: CNDP2_HUMAN, Q96KP4

Function: Hydrolyzes a variety of dipeptides including L-carnosine but has a strong preference for Cys-Gly. Isoform 2

may be play a role as tumor suppressor in hepatocellular carcinoma (HCC) cells

Catalytic activity: Hydrolysis of dipeptides, preferentially hydrophobic dipeptides including prolyl amino acids

Enzyme regulation: Inhibited by p-hydroxymercurybenzoate. The inhibitory concentration 50% (IC(50)) is 13 uM. Inhibited

by bestatin. The inhibitory concentration 50% (IC(50)) is 7 nM at pH 9.5

Biophysicochemical properties: Kinetic parameters: KM=1.04 mM for Ser-Gln (at pH 7.5 and in the presence of 0.1 mM

manganese ions); KM=0.6 mM for Cys-Gly (at pH 8.0 and in the presence of 50 uM manganese ions); KM=15 mM for carnosine

(at pH 9.5 and in the presence of 0.1 mM manganese ions);

Enzyme Number (IUBMB): EC 3.4.13.18¹

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		hsa-miR-4251
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CNDP2

Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004180	carboxypeptidase activity	TAS	--
GO:0008233	peptidase activity	--	--
GO:0008237	metallopeptidase activity	IEA	--
GO:0016805	dipeptidase activity	IEA	--
GO:0034701	tripeptidase activity	IEA	--

CNDP2 for ontologies About GeneDecksing

Animal Models:
1 MGI phenotypic allele

for Cndp2 (no phenotypes)

CNDP2 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

gamma-glutamyl cycle

gamma-glutamyl cycle

1.00

Glutathione synthesis and recycling

0.50

Biological oxidations

Biological oxidations

1.00

Phase II conjugation

0.52

Metabolism of amino acids and derivatives

Metabolism of amino acids and derivatives

1.00

Sulfur amino acid metabolism

Sulfur amino acid metabolism

1.00

Metabolism

Metabolism

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 BioSystems Pathway for CNDP2

gamma-glutamyl cycle

5/7 Reactome Pathways for CNDP2 (see all 7)

	Glutathione synthesis and recycling
	Metabolism
	Sulfur amino acid metabolism
	Biological oxidations
	Glutathione conjugation

CNDP2 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for CNDP2

STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

5/40 Interacting proteins for CNDP2 (Q96KP4^{1, 3} ENSP00000325548⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 40)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
NDRG1	Q92597¹^,³, ENSP00000319977⁴	EBI-1190734,EBI-716486 I2D: score=1 STRING: ENSP00000319977
HSPD1	P10809³, ENSP00000340019⁴	I2D: score=1 STRING: ENSP00000340019
CSE1L	P55060³, ENSP00000262982⁴	I2D: score=2 STRING: ENSP00000262982
ARFGEF1	Q9Y6D6³	I2D: score=4
RHOA	P61586³	I2D: score=4

About this table

Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000096	sulfur amino acid metabolic process	TAS	--
GO:0006508	proteolysis	IEA	--
GO:0006750	glutathione biosynthetic process	TAS	--
GO:0006805	xenobiotic metabolic process	TAS	--
GO:0034641	cellular nitrogen compound metabolic process	TAS	--

CNDP2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

CNDP2 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CNDP2
1 Novoseek chemical compound relationship for CNDP2 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
thimet	77.6	1	17277461 (1)

Search CenterWatch for drugs/clinical trials and news about CNDP2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CNDP2 gene (2 alternative transcripts):

NM_001168499.1 NM_018235.2

Unigene Cluster for CNDP2:

CNDP dipeptidase 2 (metallopeptidase M20 family)

Hs.149185 [show with all ESTs]

Unigene Representative Sequence: NM_018235

18/29 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 29):

ENST00000581272 ENST00000324262(uc021ulm.1 uc002llm.2) ENST00000580672

ENST00000583399 ENST00000579847 ENST00000583203 ENST00000582260 ENST00000581513

ENST00000580229 ENST00000577600 ENST00000579583 ENST00000584613 ENST00000583216

ENST00000581912 ENST00000582589 ENST00000583785 ENST00000324301(uc002lln.2)

ENST00000582620

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		1 QIAGEN miScript miRNA Assays for microRNA that regulate CNDP2:
		hsa-miR-4251
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Additional cDNA sequence:

AF258592.1 AJ347717.1 AK001262.1 AK001692.1 AK001983.1 AK097155.1 AK298309.1 AK300904.1

BC001375.2 BC003176.1

24/39 DOTS entries (see all 39):

DT.418336 DT.100845562 DT.100845556 DT.100845566 DT.91933901 DT.100845559 DT.100845571 DT.91769983

DT.121097376 DT.413016 DT.92410309 DT.121097402 DT.100034722 DT.121097381 DT.121097408 DT.87079100

DT.97760065 DT.100845573 DT.121097360 DT.91769989 DT.91769992 DT.100834923 DT.121097371 DT.121097422

24/667 AceView cDNA sequences (see all 667):

CF140851 BU192922 BE302753 BP346480 BU944083 BQ216659 BM423527 BQ423379

CF141464 AA406015 BE867633 BU177134 BQ057102 AL544678 CB993636 CB993588

BG171680 CD629096 BM927649 BQ958682 BQ053384 F06621 BU184087 BG697206

GeneLoc Exon Structure

5/27 Alternative Splicing Database (ASD) splice patterns (SP) for CNDP2 (see all 27) About this scheme

ExUns:	1	^	2a	·	2b	·	2c	·	2d	^	3a	·	3b	·	3c	·	3d	^	4	^	5	^	6a	·	6b	·	6c	·	6d	·	6e	·	6f	·	6g	·	6h	^	7	^	8a	·	8b	·	8c	·	8d	^	9a	·	9b	·
SP1:											-		-		-		-		-		-		-		-																-
SP2:																																									-								-		-
SP3:											-				-		-		-		-		-		-		-		-		-		-		-						-
SP4:															-		-		-		-		-		-																-
SP5:															-		-		-		-		-		-		-		-		-		-		-						-

ExUns:	9c	^	10	^	11a	·	11b	^	12a	·	12b	^	13a	·	13b	·	13c	·	13d	·	13e	^	14a	·	14b	·	14c	·	14d	^	15	^	16a	·	16b	·	16c	^	17a	·	17b	·	17c	·	17d	^	18a	·	18b	^	19a	·
SP1:																											-		-		-														-				-
SP2:	-		-		-		-		-		-																-		-		-														-				-
SP3:
SP4:
SP5:

ExUns:	19b	^	20	^	21
SP1:
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for CNDP2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CNDP2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACACCTCTAA

About this image

CNDP2 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Definitive endoderm-like cells (A scalable, suspensi...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See CNDP2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CNDP2

SOURCE GeneReport for Unigene cluster: Hs.149185

UniProtKB/Swiss-Prot: CNDP2_HUMAN, Q96KP4

Tissue specificity: Isoform 1 is ubiquitously expressed with higher levels in kidney and liver (at protein level).

Isoform 2 is expressed in fetal tissues, it is only expressed in adult liver and placental tissues

SABiosciences Custom PCR Arrays for CNDP2

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals and fungi.

Orthologs for CNDP2 gene from 7/32 species (see all 32) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	CNDP2¹	CNDP dipeptidase 2 (metallopeptidase M20 family)	75.37(n) 84.63(a)		421013 NM_001006385.1 NP_001006385.1
lizard (Anolis carolinensis)	Reptilia	CNDP2⁶	--	84(a)	1 ↔ 1	4(49200935-49225488)
African clawed frog (Xenopus laevis)	Amphibia	cn2-prov²	cytosolic nonspecific dipeptidase (EC 3.4.13.18)	76.46(n)		BC056069.1
zebrafish (Danio rerio)	Actinopterygii	wufd20d11²	Danio rerio cytosolic nonspecific dipeptidase (CN2) more	76.3(n)		AY391414.1
fruit fly (Drosophila melanogaster)	Insecta	CG17337¹	CG17337	59.5(n) 63.19(a)		35507 NM_136337.2 NP_610181.2
worm (Caenorhabditis elegans)	Secernentea	Y71H2AM.11¹	Protein Y71H2AM.11	54.96(n) 56.81(a)		175387 NM_065205.5 NP_497606.4
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	DUG1(YFR044C)⁴ DUG1¹	Cys-Gly metallo-di-peptidase; forms a complex with more⁴ Dug1p¹	54.96(n)¹ 52.13(a)¹		6(241437-239992)⁴ 850605^{1, 4} NP_116702.1^{1, 4}

ENSEMBL Gene Tree for CNDP2 (if available)
TreeFam Gene Tree for CNDP2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CNDP2 gene

CNDP1²

2 SIMAP similar genes for CNDP2 using alignment to 16 protein entries: CNDP2_HUMAN (see all proteins):

FLJ00064 CNDP1

CNDP2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 18 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs111741747^1,2		--	72161543(+)	`TTAAGA/GGTAAA`	1	--	us2k¹		2		CSA	3
rs77335781^1,2		--	72161597(+)	`AGAAAC/TATGTT`	1	--	us2k¹		0	--	--	--	--
rs8084115^1,2	C,F,	--	72161600(+)	`AACATG/ATTCAC`	1	--	us2k¹		6		WA NA CSA	246
rs149246133^1,2	C,	--	72161785(+)	`TTTGC-/TATATAC`	1	--	us2k¹		0	--	--	--	--
rs201948541^1,2		--	72161790(+)	`TATAT-/ACATATG`	1	--	us2k¹		0	--	--	--	--
rs10633165^1,2	C,	--	72161794(+)	`ACATA-/TGtgtgt`	1	--	us2k¹		0	--	--	--	--
rs144873499^1,2	C	--	72161822(+)	`TTTTT-/TAACCA`	1	--	us2k¹		0	--	--	--	--
rs190367377^1,2		--	72161905(+)	`TAGATA/TTGATT`	1	--	us2k¹		0	--	--	--	--
rs181349875^1,2		--	72161907(+)	`GATATC/GATTAA`	1	--	us2k¹		0	--	--	--	--
rs142694353^1,2		--	72161970(+)	`ATATAC/GTTTTT`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for CNDP2 (72163051 - 72190689 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CNDP2: --
Human Gene Mutation Database (HGMD): CNDP2

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CNDP2

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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CNDP2 for disorders           About GeneDecksing

OMIM gene information: 169800    OMIM disorders: --

16 diseases for CNDP2:    About MalaCards

crigler-najjar syndrome type 1 diabetes mellitus edwards syndrome gilbert syndrome

diabetes mellitus neuritis nephropathy rheumatoid arthritis

hepatocellular carcinoma arthritis prostate cancer pneumonia

prostatitis tuberculosis carcinoma mycobacterium tuberculosis

1 Novoseek disease relationship for CNDP2 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
diabetic nephropathies	49.8	4	18753673 (2), 19373489 (2), 19033401 (1), 19033402 (1)

Human Genome Epidemiology (HuGE) Navigator: CNDP2 (3 documents)

Export disorders for CNDP2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for CNDP2 gene, integrated from 9 sources (see all 36):
(articles sorted by number of sources associating them with CNDP2)

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Sequence identification and characterization of human carnosinase and a closely related non-specific dipeptidase. (PubMed id 12473676)^{1, 2, 3, 9} Teufel M....Smirnova T. (2003)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
The influence of carnosinase gene polymorphisms on diabetic nephropathy risk in African-Americans. (PubMed id 19373489)^{1, 9} McDonough C.W....Bowden D.W. (2009)
Exclusion of polymorphisms in carnosinase genes (CNDP1 and CNDP2) as a cause of diabetic nephropathy in type 1 diabetes: results of large case-control and follow-up studies. (PubMed id 18753673)^{1, 9} Wanic K....Krolewski A.S. (2008)
A census of human soluble protein complexes. (PubMed id 22939629)¹ Havugimana P.C....Emili A. (2012)
Proteomic profiling of the substantia nigra demonstrat es CNDP2 overexpression in Parkinson's disease. (PubMed id 22410244)¹ Licker V....Burkhard P.R. (2012)
A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)¹ Kristensen A.R....Foster L.J. (2012)
Loss of 18q22.3 involving the carboxypeptidase of glut amate-like gene is associated with poor prognosis in resected pancreatic cancer. (PubMed id 22128300)¹ Lee J.H....Giaccone G. (2012)
Initial characterization of the human central proteome. (PubMed id 21269460)² Burkard T.R.... Colinge J. (2011)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 55748	HGNC: 24437	AceView: CNDP2	Ensembl:ENSG00000133313	euGenes: HUgn55748
ECgene: CNDP2	H-InvDB: CNDP2

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for CNDP2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for CNDP2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for CNDP2 gene:
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GeneCards and IP:
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CNDP2 Gene

CNDP dipeptidase 2 (metallopeptidase M20 family)

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CNDP dipeptidase 2 (metallopeptidase M20 family)

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