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Aliases for CNDP2 Gene

Aliases for CNDP2 Gene

  • CNDP Dipeptidase 2 (Metallopeptidase M20 Family) 2 3 5
  • Carnosine Dipeptidase II 2 3 4
  • Peptidase A 2 3 4
  • Glutamate Carboxypeptidase-Like Protein 1 3 4
  • Epididymis Secretory Protein Li 13 3 4
  • Cytosolic Nonspecific Dipeptidase 2 3
  • HEL-S-13 3 4
  • PEPA 3 4
  • CPGL 3 4
  • CN2 3 4
  • CNDP Dipeptidase 2 4
  • EC 3.4.13.18 4
  • HsT2298 3

External Ids for CNDP2 Gene

Previous HGNC Symbols for CNDP2 Gene

  • PEPA

Previous GeneCards Identifiers for CNDP2 Gene

  • GC18P070313
  • GC18P070314
  • GC18P072163
  • GC18P068895

Summaries for CNDP2 Gene

Entrez Gene Summary for CNDP2 Gene

  • CNDP2, also known as tissue carnosinase and peptidase A (EC 3.4.13.18), is a nonspecific dipeptidase rather than a selective carnosinase (Teufel et al., 2003 [PubMed 12473676]).[supplied by OMIM, Mar 2008]

GeneCards Summary for CNDP2 Gene

CNDP2 (CNDP Dipeptidase 2 (Metallopeptidase M20 Family)) is a Protein Coding gene. Diseases associated with CNDP2 include pyriform sinus cancer and hypopharynx cancer. Among its related pathways are Metabolism and Phase II conjugation. GO annotations related to this gene include hydrolase activity and metallopeptidase activity. An important paralog of this gene is CNDP1.

UniProtKB/Swiss-Prot for CNDP2 Gene

  • Hydrolyzes a variety of dipeptides including L-carnosine but has a strong preference for Cys-Gly (PubMed:19346245). Acts as a functional tumor suppressor in gastric cancer via activation of the mitogen-activated protein kinase (MAPK) pathway. An elevated level of CNDP2 activates the p38 and JNK MAPK pathways to induce cell apoptosis, and a lower level of CNDP2 activates the ERK MAPK pathway to promote cell proliferation (PubMed:24395568). Isoform 2 may play a role as tumor suppressor in hepatocellular carcinoma (HCC) cells (PubMed:17121880). Catalyzes the production of N-lactoyl-amino acids from lactate and amino acids by reverse proteolysis (PubMed:25964343).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CNDP2 Gene

Genomics for CNDP2 Gene

Regulatory Elements for CNDP2 Gene

Promoters for CNDP2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CNDP2 on UCSC Golden Path with GeneCards custom track

Genomic Location for CNDP2 Gene

Chromosome:
18
Start:
74,495,816 bp from pter
End:
74,523,454 bp from pter
Size:
27,639 bases
Orientation:
Plus strand

Genomic View for CNDP2 Gene

Genes around CNDP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CNDP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CNDP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CNDP2 Gene

Proteins for CNDP2 Gene

  • Protein details for CNDP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96KP4-CNDP2_HUMAN
    Recommended name:
    Cytosolic non-specific dipeptidase
    Protein Accession:
    Q96KP4
    Secondary Accessions:
    • B3KUG4
    • Q8WY59
    • Q9BQ94
    • Q9NVB4
    • V9HWE5

    Protein attributes for CNDP2 Gene

    Size:
    475 amino acids
    Molecular mass:
    52878 Da
    Cofactor:
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    • Homodimer.
    Miscellaneous:
    • The reverse proteolysis is not negligible in vivo as long as the substrates are present in considerable concentrations, such as upon physical exercice. N-lac-Phe plasma levels are increased in patients with PKU with increased plasma Phe levels. N-lactoyl-amino acids are present in many tissues.

    Three dimensional structures from OCA and Proteopedia for CNDP2 Gene

    Alternative splice isoforms for CNDP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CNDP2 Gene

Proteomics data for CNDP2 Gene at MOPED

Post-translational modifications for CNDP2 Gene

  • Ubiquitination at Lys 24, Lys 383, and Lys 402
  • Modification sites at PhosphoSitePlus

Antibody Products

  • R&D Systems Antibodies for CNDP2 (Cytosol Nonspecific Dipeptidase (CNDP2)/CPGL)
  • Santa Cruz Biotechnology (SCBT) Antibodies for CNDP2

No data available for DME Specific Peptides for CNDP2 Gene

Domains & Families for CNDP2 Gene

Gene Families for CNDP2 Gene

Suggested Antigen Peptide Sequences for CNDP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96KP4

UniProtKB/Swiss-Prot:

CNDP2_HUMAN :
  • Belongs to the peptidase M20A family.
Family:
  • Belongs to the peptidase M20A family.
genes like me logo Genes that share domains with CNDP2: view

Function for CNDP2 Gene

Molecular function for CNDP2 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=1.04 mM for Ser-Gln (at pH 7.5 and in the presence of 0.1 mM manganese ions) {ECO:0000269 PubMed:12473676, ECO:0000269 PubMed:19346245}; KM=0.6 mM for Cys-Gly (at pH 8.0 and in the presence of 50 uM manganese ions) {ECO:0000269 PubMed:12473676, ECO:0000269 PubMed:19346245}; KM=15 mM for carnosine (at pH 9.5 and in the presence of 0.1 mM manganese ions) {ECO:0000269 PubMed:12473676, ECO:0000269 PubMed:19346245};
UniProtKB/Swiss-Prot CatalyticActivity:
Hydrolysis of dipeptides, preferentially hydrophobic dipeptides including prolyl amino acids.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by p-hydroxymercurybenzoate. The inhibitory concentration 50% (IC(50)) is 13 uM. Inhibited by bestatin. The inhibitory concentration 50% (IC(50)) is 7 nM at pH 9.5.
UniProtKB/Swiss-Prot Function:
Hydrolyzes a variety of dipeptides including L-carnosine but has a strong preference for Cys-Gly (PubMed:19346245). Acts as a functional tumor suppressor in gastric cancer via activation of the mitogen-activated protein kinase (MAPK) pathway. An elevated level of CNDP2 activates the p38 and JNK MAPK pathways to induce cell apoptosis, and a lower level of CNDP2 activates the ERK MAPK pathway to promote cell proliferation (PubMed:24395568). Isoform 2 may play a role as tumor suppressor in hepatocellular carcinoma (HCC) cells (PubMed:17121880). Catalyzes the production of N-lactoyl-amino acids from lactate and amino acids by reverse proteolysis (PubMed:25964343).

Enzyme Numbers (IUBMB) for CNDP2 Gene

Gene Ontology (GO) - Molecular Function for CNDP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004180 carboxypeptidase activity TAS --
GO:0008237 metallopeptidase activity IEA --
genes like me logo Genes that share ontologies with CNDP2: view
genes like me logo Genes that share phenotypes with CNDP2: view

Animal Model Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CNDP2 Gene

Localization for CNDP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CNDP2 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CNDP2 Gene COMPARTMENTS Subcellular localization image for CNDP2 gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 5
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for CNDP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with CNDP2: view

Pathways & Interactions for CNDP2 Gene

genes like me logo Genes that share pathways with CNDP2: view

Gene Ontology (GO) - Biological Process for CNDP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006805 xenobiotic metabolic process TAS --
GO:0008152 metabolic process IEA --
GO:0034641 cellular nitrogen compound metabolic process TAS --
genes like me logo Genes that share ontologies with CNDP2: view

No data available for SIGNOR curated interactions for CNDP2 Gene

Drugs & Compounds for CNDP2 Gene

(1) Additional Compounds for CNDP2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CNDP2: view

Transcripts for CNDP2 Gene

Unigene Clusters for CNDP2 Gene

CNDP dipeptidase 2 (metallopeptidase M20 family):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CNDP2 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c · 3d ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e · 6f · 6g · 6h ^ 7 ^ 8a · 8b · 8c · 8d ^ 9a · 9b ·
SP1: - - - - - - - - -
SP2: - - -
SP3: - - - - - - - - - - - - -
SP4: - - - - - - -
SP5: - - - - - - - - - - - -
SP6: -
SP7:
SP8: - - - - - - - - - - - - - - - - - -
SP9: - - - - - - - - - - - -
SP10: - - - - - - - -
SP11: -
SP12: - - - - - - - - - - -
SP13: - - - - - - - - - - -
SP14: -
SP15: - - -
SP16: - - - -
SP17:
SP18: - - - - - - - - - - - - - - - - - - -
SP19: - - - - - - - - - - -
SP20: - - -
SP21: -
SP22:
SP23:
SP24:
SP25:
SP26:
SP27: -

ExUns: 9c ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b · 13c · 13d · 13e ^ 14a · 14b · 14c · 14d ^ 15 ^ 16a · 16b · 16c ^ 17a · 17b · 17c · 17d ^ 18a · 18b ^ 19a ·
SP1: - - - - -
SP2: - - - - - - - - - - -
SP3:
SP4:
SP5:
SP6: - - -
SP7: - -
SP8:
SP9:
SP10:
SP11:
SP12:
SP13: - - -
SP14: - - - -
SP15: - - - - - -
SP16: -
SP17: - -
SP18:
SP19:
SP20:
SP21: - - - - - - - - - - - - - -
SP22:
SP23: - - - - - - -
SP24: - - -
SP25: -
SP26: -
SP27:

ExUns: 19b ^ 20 ^ 21
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:
SP23:
SP24:
SP25:
SP26:
SP27:

Relevant External Links for CNDP2 Gene

GeneLoc Exon Structure for
CNDP2
ECgene alternative splicing isoforms for
CNDP2

Expression for CNDP2 Gene

mRNA expression in normal human tissues for CNDP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CNDP2 Gene

This gene is overexpressed in Kidney - Cortex (x4.9).

Protein differential expression in normal tissues from HIPED for CNDP2 Gene

This gene is overexpressed in Spleen (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CNDP2 Gene



SOURCE GeneReport for Unigene cluster for CNDP2 Gene Hs.149185

mRNA Expression by UniProt/SwissProt for CNDP2 Gene

Q96KP4-CNDP2_HUMAN
Tissue specificity: Isoform 1 is ubiquitously expressed with higher levels in kidney and liver (at protein level). Expressed in peripheral blood leukocytes (PubMed:12473676). Isoform 2 is expressed in fetal tissues, it is only expressed in adult liver and placental tissues. Down-regulated in gastric cancer tissues (at protein level) (PubMed:24395568).
genes like me logo Genes that share expression patterns with CNDP2: view

Protein tissue co-expression partners for CNDP2 Gene

Primer Products

In Situ Assay Products

Orthologs for CNDP2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CNDP2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CNDP2 35
  • 84.98 (n)
  • 91.37 (a)
CNDP2 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CNDP2 35
  • 86.82 (n)
  • 91.75 (a)
CNDP2 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cndp2 35
  • 84.91 (n)
  • 91.16 (a)
Cndp2 16
Cndp2 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CNDP2 35
  • 98.95 (n)
  • 98.95 (a)
CNDP2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cndp2 35
  • 84.49 (n)
  • 90.32 (a)
oppossum
(Monodelphis domestica)
Mammalia CNDP2 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 84 (a)
OneToMany
-- 36
  • 84 (a)
OneToMany
chicken
(Gallus gallus)
Aves CNDP2 35
  • 75.37 (n)
  • 84.63 (a)
CNDP2 36
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CNDP2 36
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cndp2 35
  • 73.77 (n)
  • 81.22 (a)
MGC75655 35
African clawed frog
(Xenopus laevis)
Amphibia cn2-prov 35
zebrafish
(Danio rerio)
Actinopterygii cndp2 35
  • 69.91 (n)
  • 75.48 (a)
wufd20d11 35
cndp2 36
  • 78 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11239 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007619 35
  • 61.06 (n)
  • 63.62 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG17337 35
  • 59.32 (n)
  • 62.92 (a)
CG17337 36
  • 62 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y71H2AM.11 35
  • 54.96 (n)
  • 56.81 (a)
pes-9 36
  • 57 (a)
ManyToMany
Y71H2AM.11 36
  • 57 (a)
ManyToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR252C 35
  • 57.56 (n)
  • 52.69 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A01001g 35
  • 54.86 (n)
  • 53.78 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DUG1 35
  • 54.96 (n)
  • 52.13 (a)
DUG1 36
  • 51 (a)
OneToMany
DUG1 38
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4756 35
bread mold
(Neurospora crassa)
Ascomycetes NCU07153 35
  • 57.01 (n)
  • 52.79 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC1198.08 35
  • 53.76 (n)
  • 52.55 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3123 36
  • 71 (a)
OneToOne
Species with no ortholog for CNDP2:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CNDP2 Gene

ENSEMBL:
Gene Tree for CNDP2 (if available)
TreeFam:
Gene Tree for CNDP2 (if available)

Paralogs for CNDP2 Gene

Paralogs for CNDP2 Gene

genes like me logo Genes that share paralogs with CNDP2: view

Variants for CNDP2 Gene

Sequence variations from dbSNP and Humsavar for CNDP2 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs2278161 - 74,508,848(-) CCCAT(A/G)CAGCT intron-variant, reference, missense
rs7577 -- 74,521,112(-) GTGTC(A/G)TGTTT utr-variant-3-prime
rs15165 -- 74,521,016(-) AAAAT(A/G)CCAGT utr-variant-3-prime
rs890334 -- 74,521,136(-) TGAGA(C/T)GGAGC downstream-variant-500B, utr-variant-3-prime
rs890335 -- 74,521,017(-) GAAAA(A/C/G/T)GCCAG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CNDP2 Gene

Variant ID Type Subtype PubMed ID
nsv909916 CNV Gain 21882294
dgv3467n71 CNV Loss 21882294
esv2717347 CNV Deletion 23290073
esv2717348 CNV Deletion 23290073
esv1617659 CNV Insertion 17803354
nsv909919 CNV Gain 21882294

Variation tolerance for CNDP2 Gene

Residual Variation Intolerance Score: 35.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.43; 88.61% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CNDP2 Gene

HapMap Linkage Disequilibrium report
CNDP2
Human Gene Mutation Database (HGMD)
CNDP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CNDP2 Gene

Disorders for CNDP2 Gene

MalaCards: The human disease database

(3) MalaCards diseases for CNDP2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
pyriform sinus cancer
  • malignant neoplasm of pyriform fossa
hypopharynx cancer
  • hypopharyngeal cancer
gastric cancer
  • stomach cancer
- elite association - COSMIC cancer census association via MalaCards
Search CNDP2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CNDP2

Genetic Association Database (GAD)
CNDP2
Human Genome Epidemiology (HuGE) Navigator
CNDP2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CNDP2
genes like me logo Genes that share disorders with CNDP2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CNDP2 Gene

Publications for CNDP2 Gene

  1. Sequence identification and characterization of human carnosinase and a closely related non-specific dipeptidase. (PMID: 12473676) Teufel M. … Smirnova T. (J. Biol. Chem. 2003) 2 3 4 23 67
  2. The influence of carnosinase gene polymorphisms on diabetic nephropathy risk in African-Americans. (PMID: 19373489) McDonough C.W. … Bowden D.W. (Hum. Genet. 2009) 3 23
  3. Exclusion of polymorphisms in carnosinase genes (CNDP1 and CNDP2) as a cause of diabetic nephropathy in type 1 diabetes: results of large case-control and follow-up studies. (PMID: 18753673) Wanic K. … Krolewski A.S. (Diabetes 2008) 3 23
  4. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A. … Stelzl U. (Mol. Syst. Biol. 2015) 3
  5. N-lactoyl-amino acids are ubiquitous metabolites that originate from CNDP2-mediated reverse proteolysis of lactate and amino acids. (PMID: 25964343) Jansen R.S. … van de Wetering K. (Proc. Natl. Acad. Sci. U.S.A. 2015) 3

Products for CNDP2 Gene

Sources for CNDP2 Gene

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