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Aliases for CNDP2 Gene

Aliases for CNDP2 Gene

  • CNDP Dipeptidase 2 (Metallopeptidase M20 Family) 2 3 5
  • Carnosine Dipeptidase II 2 3 4
  • Peptidase A 2 3 4
  • Glutamate Carboxypeptidase-Like Protein 1 3 4
  • Epididymis Secretory Protein Li 13 3 4
  • Cytosolic Nonspecific Dipeptidase 2 3
  • HEL-S-13 3 4
  • PEPA 3 4
  • CPGL 3 4
  • CN2 3 4
  • Cytosolic Non-Specific Dipeptidase 3
  • CNDP Dipeptidase 2 4
  • EC 3.4.13.18 4
  • HsT2298 3

External Ids for CNDP2 Gene

Previous HGNC Symbols for CNDP2 Gene

  • PEPA

Previous GeneCards Identifiers for CNDP2 Gene

  • GC18P070313
  • GC18P070314
  • GC18P072163
  • GC18P068895

Summaries for CNDP2 Gene

Entrez Gene Summary for CNDP2 Gene

  • CNDP2, also known as tissue carnosinase and peptidase A (EC 3.4.13.18), is a nonspecific dipeptidase rather than a selective carnosinase (Teufel et al., 2003 [PubMed 12473676]).[supplied by OMIM, Mar 2008]

GeneCards Summary for CNDP2 Gene

CNDP2 (CNDP Dipeptidase 2 (Metallopeptidase M20 Family)) is a Protein Coding gene. Diseases associated with CNDP2 include Pyriform Sinus Cancer and Aspiration Pneumonitis. Among its related pathways are Metabolism and Cytochrome P450 - arranged by substrate type. GO annotations related to this gene include hydrolase activity and metallopeptidase activity. An important paralog of this gene is CNDP1.

UniProtKB/Swiss-Prot for CNDP2 Gene

  • Hydrolyzes a variety of dipeptides including L-carnosine but has a strong preference for Cys-Gly (PubMed:19346245). Acts as a functional tumor suppressor in gastric cancer via activation of the mitogen-activated protein kinase (MAPK) pathway. An elevated level of CNDP2 activates the p38 and JNK MAPK pathways to induce cell apoptosis, and a lower level of CNDP2 activates the ERK MAPK pathway to promote cell proliferation (PubMed:24395568). Isoform 2 may play a role as tumor suppressor in hepatocellular carcinoma (HCC) cells (PubMed:17121880). Catalyzes the production of N-lactoyl-amino acids from lactate and amino acids by reverse proteolysis (PubMed:25964343).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CNDP2 Gene

Genomics for CNDP2 Gene

Regulatory Elements for CNDP2 Gene

Enhancers for CNDP2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH18F074495 0.9 ENCODE 22.3 +3.2 3196 7.2 HDGF PKNOX1 WRNIP1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 CNDP2 CNDP1 ENSG00000276934
GH18F074480 1.2 FANTOM5 Ensembl ENCODE 21.4 -15.2 -15240 2.4 ELF3 HDAC1 PKNOX1 ARNT RAD21 YY1 GATA2 THAP11 CEBPB ZEB2 CNDP2 FAM69C
GH18F074463 0.2 ENCODE 16.4 -32.4 -32399 0.8 RNF2 CNDP2 FAM69C GC18M074426
GH18F074459 0.2 ENCODE 16.1 -35.4 -35424 1.4 CTCF ZNF366 ZNF24 CNDP2 FAM69C GC18M074426
GH18F074505 0.5 ENCODE 15.8 +12.0 12029 4.4 ARID1B ZNF316 GATA2 TAL1 MAFG EMSY MAFK CNDP2 CNDP1 GC18P074507
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around CNDP2 on UCSC Golden Path with GeneCards custom track

Promoters for CNDP2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000528186 485 2200 HDGF PKNOX1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 FOS

Genomic Location for CNDP2 Gene

Chromosome:
18
Start:
74,495,816 bp from pter
End:
74,523,454 bp from pter
Size:
27,639 bases
Orientation:
Plus strand

Genomic View for CNDP2 Gene

Genes around CNDP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CNDP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CNDP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CNDP2 Gene

Proteins for CNDP2 Gene

  • Protein details for CNDP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96KP4-CNDP2_HUMAN
    Recommended name:
    Cytosolic non-specific dipeptidase
    Protein Accession:
    Q96KP4
    Secondary Accessions:
    • B3KUG4
    • Q8WY59
    • Q9BQ94
    • Q9NVB4
    • V9HWE5

    Protein attributes for CNDP2 Gene

    Size:
    475 amino acids
    Molecular mass:
    52878 Da
    Cofactor:
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    • Homodimer.
    Miscellaneous:
    • The reverse proteolysis is not negligible in vivo as long as the substrates are present in considerable concentrations, such as upon physical exercice. N-lac-Phe plasma levels are increased in patients with PKU with increased plasma Phe levels. N-lactoyl-amino acids are present in many tissues.

    Three dimensional structures from OCA and Proteopedia for CNDP2 Gene

    Alternative splice isoforms for CNDP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CNDP2 Gene

Post-translational modifications for CNDP2 Gene

  • Ubiquitination at Lys 24, Lys 383, and Lys 402
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CNDP2 Gene

Domains & Families for CNDP2 Gene

Gene Families for CNDP2 Gene

Suggested Antigen Peptide Sequences for CNDP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96KP4

UniProtKB/Swiss-Prot:

CNDP2_HUMAN :
  • Belongs to the peptidase M20A family.
Family:
  • Belongs to the peptidase M20A family.
genes like me logo Genes that share domains with CNDP2: view

Function for CNDP2 Gene

Molecular function for CNDP2 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=1.04 mM for Ser-Gln (at pH 7.5 and in the presence of 0.1 mM manganese ions) {ECO:0000269 PubMed:12473676, ECO:0000269 PubMed:19346245}; KM=0.6 mM for Cys-Gly (at pH 8.0 and in the presence of 50 uM manganese ions) {ECO:0000269 PubMed:12473676, ECO:0000269 PubMed:19346245}; KM=15 mM for carnosine (at pH 9.5 and in the presence of 0.1 mM manganese ions) {ECO:0000269 PubMed:12473676, ECO:0000269 PubMed:19346245};
UniProtKB/Swiss-Prot CatalyticActivity:
Hydrolysis of dipeptides, preferentially hydrophobic dipeptides including prolyl amino acids.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by p-hydroxymercurybenzoate. The inhibitory concentration 50% (IC(50)) is 13 uM. Inhibited by bestatin. The inhibitory concentration 50% (IC(50)) is 7 nM at pH 9.5.
UniProtKB/Swiss-Prot Function:
Hydrolyzes a variety of dipeptides including L-carnosine but has a strong preference for Cys-Gly (PubMed:19346245). Acts as a functional tumor suppressor in gastric cancer via activation of the mitogen-activated protein kinase (MAPK) pathway. An elevated level of CNDP2 activates the p38 and JNK MAPK pathways to induce cell apoptosis, and a lower level of CNDP2 activates the ERK MAPK pathway to promote cell proliferation (PubMed:24395568). Isoform 2 may play a role as tumor suppressor in hepatocellular carcinoma (HCC) cells (PubMed:17121880). Catalyzes the production of N-lactoyl-amino acids from lactate and amino acids by reverse proteolysis (PubMed:25964343).

Enzyme Numbers (IUBMB) for CNDP2 Gene

Gene Ontology (GO) - Molecular Function for CNDP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004180 carboxypeptidase activity TAS --
GO:0008233 peptidase activity IEA --
GO:0008237 metallopeptidase activity IEA --
GO:0008270 zinc ion binding IBA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with CNDP2: view
genes like me logo Genes that share phenotypes with CNDP2: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CNDP2 Gene

Localization for CNDP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CNDP2 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CNDP2 Gene COMPARTMENTS Subcellular localization image for CNDP2 gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 5
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for CNDP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with CNDP2: view

Pathways & Interactions for CNDP2 Gene

genes like me logo Genes that share pathways with CNDP2: view

Gene Ontology (GO) - Biological Process for CNDP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000096 sulfur amino acid metabolic process TAS --
GO:0006508 proteolysis IEA --
GO:0006750 glutathione biosynthetic process TAS --
GO:0008152 metabolic process IEA --
GO:0043171 peptide catabolic process IBA --
genes like me logo Genes that share ontologies with CNDP2: view

No data available for SIGNOR curated interactions for CNDP2 Gene

Drugs & Compounds for CNDP2 Gene

(1) Additional Compounds for CNDP2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CNDP2: view

Transcripts for CNDP2 Gene

Unigene Clusters for CNDP2 Gene

CNDP dipeptidase 2 (metallopeptidase M20 family):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CNDP2 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c · 3d ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e · 6f · 6g · 6h ^ 7 ^ 8a · 8b · 8c · 8d ^ 9a · 9b ·
SP1: - - - - - - - - -
SP2: - - -
SP3: - - - - - - - - - - - - -
SP4: - - - - - - -
SP5: - - - - - - - - - - - -
SP6: -
SP7:
SP8: - - - - - - - - - - - - - - - - - -
SP9: - - - - - - - - - - - -
SP10: - - - - - - - -
SP11: -
SP12: - - - - - - - - - - -
SP13: - - - - - - - - - - -
SP14: -
SP15: - - -
SP16: - - - -
SP17:
SP18: - - - - - - - - - - - - - - - - - - -
SP19: - - - - - - - - - - -
SP20: - - -
SP21: -
SP22:
SP23:
SP24:
SP25:
SP26:
SP27: -

ExUns: 9c ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b · 13c · 13d · 13e ^ 14a · 14b · 14c · 14d ^ 15 ^ 16a · 16b · 16c ^ 17a · 17b · 17c · 17d ^ 18a · 18b ^ 19a ·
SP1: - - - - -
SP2: - - - - - - - - - - -
SP3:
SP4:
SP5:
SP6: - - -
SP7: - -
SP8:
SP9:
SP10:
SP11:
SP12:
SP13: - - -
SP14: - - - -
SP15: - - - - - -
SP16: -
SP17: - -
SP18:
SP19:
SP20:
SP21: - - - - - - - - - - - - - -
SP22:
SP23: - - - - - - -
SP24: - - -
SP25: -
SP26: -
SP27:

ExUns: 19b ^ 20 ^ 21
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:
SP23:
SP24:
SP25:
SP26:
SP27:

Relevant External Links for CNDP2 Gene

GeneLoc Exon Structure for
CNDP2
ECgene alternative splicing isoforms for
CNDP2

Expression for CNDP2 Gene

mRNA expression in normal human tissues for CNDP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CNDP2 Gene

This gene is overexpressed in Kidney - Cortex (x4.9).

Protein differential expression in normal tissues from HIPED for CNDP2 Gene

This gene is overexpressed in Spleen (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CNDP2 Gene



Protein tissue co-expression partners for CNDP2 Gene

NURSA nuclear receptor signaling pathways regulating expression of CNDP2 Gene:

CNDP2

SOURCE GeneReport for Unigene cluster for CNDP2 Gene:

Hs.149185

mRNA Expression by UniProt/SwissProt for CNDP2 Gene:

Q96KP4-CNDP2_HUMAN
Tissue specificity: Isoform 1 is ubiquitously expressed with higher levels in kidney and liver (at protein level). Expressed in peripheral blood leukocytes (PubMed:12473676). Isoform 2 is expressed in fetal tissues, it is only expressed in adult liver and placental tissues. Down-regulated in gastric cancer tissues (at protein level) (PubMed:24395568).
genes like me logo Genes that share expression patterns with CNDP2: view

Primer Products

Orthologs for CNDP2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CNDP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CNDP2 34 35
  • 98.95 (n)
dog
(Canis familiaris)
Mammalia CNDP2 34 35
  • 86.82 (n)
cow
(Bos Taurus)
Mammalia CNDP2 34 35
  • 84.98 (n)
mouse
(Mus musculus)
Mammalia Cndp2 34 16 35
  • 84.91 (n)
rat
(Rattus norvegicus)
Mammalia Cndp2 34
  • 84.49 (n)
oppossum
(Monodelphis domestica)
Mammalia CNDP2 35
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 84 (a)
OneToMany
-- 35
  • 84 (a)
OneToMany
chicken
(Gallus gallus)
Aves CNDP2 34 35
  • 75.37 (n)
lizard
(Anolis carolinensis)
Reptilia CNDP2 35
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cndp2 34
  • 73.77 (n)
MGC75655 34
African clawed frog
(Xenopus laevis)
Amphibia cn2-prov 34
zebrafish
(Danio rerio)
Actinopterygii cndp2 34 35
  • 69.91 (n)
wufd20d11 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11239 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007619 34
  • 61.06 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG17337 34 35
  • 59.32 (n)
worm
(Caenorhabditis elegans)
Secernentea pes-9 35
  • 57 (a)
ManyToMany
Y71H2AM.11 34 35
  • 54.96 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR252C 34
  • 57.56 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DUG1 34 35 37
  • 54.96 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A01001g 34
  • 54.86 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3123 35
  • 71 (a)
OneToOne
bread mold
(Neurospora crassa)
Ascomycetes NCU07153 34
  • 57.01 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC1198.08 34
  • 53.76 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4756 34
Species where no ortholog for CNDP2 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CNDP2 Gene

ENSEMBL:
Gene Tree for CNDP2 (if available)
TreeFam:
Gene Tree for CNDP2 (if available)

Paralogs for CNDP2 Gene

Paralogs for CNDP2 Gene

genes like me logo Genes that share paralogs with CNDP2: view

Variants for CNDP2 Gene

Sequence variations from dbSNP and Humsavar for CNDP2 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs1035759 -- 74,523,018(-) TTGCA(A/G)AGATG utr-variant-3-prime
rs1035760 -- 74,517,002(-) AGCTA(C/T)CGCGT intron-variant
rs10551087 -- 74,509,742(+) AAGAC(-/AGTT)AGTAT intron-variant
rs10579374 -- 74,516,624(+) TTGAC(-/CTCA)CTCAC intron-variant
rs10633165 -- 74,494,559(+) ACATA(-/TG)TGTGT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CNDP2 Gene

Variant ID Type Subtype PubMed ID
esv1617659 CNV insertion 17803354
esv2717347 CNV deletion 23290073
esv2717348 CNV deletion 23290073
esv3643117 CNV loss 21293372
esv3643118 CNV gain 21293372
esv3643121 CNV gain 21293372
nsv1057441 CNV gain 25217958
nsv1150778 CNV deletion 26484159
nsv577655 CNV loss 21841781

Variation tolerance for CNDP2 Gene

Residual Variation Intolerance Score: 35.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.43; 88.61% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CNDP2 Gene

Human Gene Mutation Database (HGMD)
CNDP2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CNDP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CNDP2 Gene

Disorders for CNDP2 Gene

MalaCards: The human disease database

(4) MalaCards diseases for CNDP2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
pyriform sinus cancer
  • malignant neoplasm of pyriform fossa
aspiration pneumonitis
  • aspiration pneumonia
hypopharynx cancer
  • hypopharyngeal cancer
crigler-najjar syndrome, type i
  • crigler-najjar syndrome
- elite association - COSMIC cancer census association via MalaCards
Search CNDP2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CNDP2

Genetic Association Database (GAD)
CNDP2
Human Genome Epidemiology (HuGE) Navigator
CNDP2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CNDP2
genes like me logo Genes that share disorders with CNDP2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CNDP2 Gene

Publications for CNDP2 Gene

  1. Sequence identification and characterization of human carnosinase and a closely related non-specific dipeptidase. (PMID: 12473676) Teufel M. … Smirnova T. (J. Biol. Chem. 2003) 2 3 4 22 64
  2. The influence of carnosinase gene polymorphisms on diabetic nephropathy risk in African-Americans. (PMID: 19373489) McDonough C.W. … Bowden D.W. (Hum. Genet. 2009) 3 22 46 64
  3. Exclusion of polymorphisms in carnosinase genes (CNDP1 and CNDP2) as a cause of diabetic nephropathy in type 1 diabetes: results of large case-control and follow-up studies. (PMID: 18753673) Wanic K. … Krolewski A.S. (Diabetes 2008) 3 22 46 64
  4. N-lactoyl-amino acids are ubiquitous metabolites that originate from CNDP2-mediated reverse proteolysis of lactate and amino acids. (PMID: 25964343) Jansen R.S. … van de Wetering K. (Proc. Natl. Acad. Sci. U.S.A. 2015) 3 4 64
  5. The Under-expressed CNDP2 Participates in Gastric Cancer Growth Inhibition through Activating the MAPK Signalling Pathway. (PMID: 24395568) Zhang Z. … Jiao B. (Mol. Med. 2013) 3 4 64

Products for CNDP2 Gene

Sources for CNDP2 Gene

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