Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



CNDP1 Gene

protein-coding   GIFtS: 66
GCID: GC18P072201

Carnosine Dipeptidase 1 (Metallopeptidase M20 Family)

  See CNDP1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Carnosine Dipeptidase 1 (Metallopeptidase M20 Family)1 2     CNDP Dipeptidase 12 3
Glutamate Carboxypeptidase-Like Protein 21 2 3     HsT23082
CN12 3 5     Beta-Ala-His Dipeptidase2
Carnosinase 11 2     EC 3.4.13.203
Serum Carnosinase2 3     Carnosine Dipeptidase 13
CPGL22 3     

External Ids:    HGNC: 206751   Entrez Gene: 847352   Ensembl: ENSG000001506567   OMIM: 6090645   UniProtKB: Q96KN23   

Export aliases for CNDP1 gene to outside databases

Previous GC identifers: GC18P070351 GC18P070352 GC18P068933


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for CNDP1 Gene:
This gene encodes a member of the M20 metalloprotease family. The encoded protein is specifically expressed in the
brain, is a homodimeric dipeptidase which was identified as human carnosinase. This gene contains trinucleotide
(CTG) repeat length polymorphism in the coding region. (provided by RefSeq, Jul 2008)

GeneCards Summary for CNDP1 Gene:
CNDP1 (carnosine dipeptidase 1 (metallopeptidase M20 family)) is a protein-coding gene. Diseases associated with CNDP1 include homocarnosinosis, and diabetic nephropathy. GO annotations related to this gene include metallopeptidase activity and dipeptidase activity. An important paralog of this gene is CNDP2.

Gene Wiki entry for CNDP1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000018.9  NC_018929.2  NT_010966.15  
Regulatory elements:
   Regulatory transcription factor binding sites in the CNDP1 gene promoter:
         FOXD3   CUTL1   HNF-4alpha2   LCR-F1   HNF-4alpha1   AREB6   HOXA5   ARP-1   STAT3   ZID   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCNDP1 promoter sequence
   Search Chromatin IP Primers for CNDP1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CNDP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q22.3   Ensembl cytogenetic band:  18q22.3   HGNC cytogenetic band: 18q22.3

CNDP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CNDP1 gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18P072201:  view genomic region     (about GC identifiers)

Start:
72,201,675 bp from pter      End:
72,254,448 bp from pter
Size:
52,774 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: CNDP1_HUMAN, Q96KN2 (See protein sequence)
Recommended Name: Beta-Ala-His dipeptidase precursor  
Size: 507 amino acids; 56706 Da
Cofactor: Binds 2 zinc ions per subunit
Subunit: Homodimer
1 PDB 3D structure from and Proteopedia for CNDP1:
3DLJ (3D)    
Secondary accessions: Q14D40 Q17S05 Q2TBG0 Q6UWK2 Q9BT98

Explore the universe of human proteins at neXtProt for CNDP1: NX_Q96KN2

Explore proteomics data for CNDP1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn322, Asn382
  • Modification sites at PhosphoSitePlus

  • See CNDP1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_116038.4  
    ENSEMBL proteins: 
     ENSP00000351682   ENSP00000462096   ENSP00000463807  

    CNDP1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for CNDP1 (Carnosine Dipeptidase 1/CNDP1)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for CNDP1
    OriGene Protein Over-expression Lysate for CNDP1
    OriGene MassSpec for CNDP1
    OriGene Custom Protein Services for CNDP1
    GenScript Custom Purified and Recombinant Proteins Services for CNDP1
    Novus Biologicals CNDP1 Protein
    Novus Biologicals CNDP1 Lysates
    Sino Biological Recombinant Protein for CNDP1
    Sino Biological Cell Lysate for CNDP1
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CNDP1

     
    Search eBioscience for Proteins for CNDP1 

    CNDP1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for CNDP1 (Carnosine Dipeptidase 1/CNDP1)
    OriGene Antibodies for CNDP1
    OriGene Custom Antibody Services for CNDP1
    Novus Biologicals CNDP1 Antibodies
    Abcam antibodies for CNDP1
    Cloud-Clone Corp. Antibodies for CNDP1
    ThermoFisher Antibody for CNDP1
    LSBio Antibodies in human, mouse, rat for CNDP1

    CNDP1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CNDP1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CNDP1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CNDP1
    Cloud-Clone Corp. CLIAs for CNDP1
    Search eBioscience for ELISAs for CNDP1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    IUPHAR Guide to PHARMACOLOGY protein family classification: Carnosine dipeptidase 1 (metallopeptidase M20 family)
    Metallocarboxypeptidases

    4 InterPro protein domains:
     IPR017153 GSH_degradosome_DUG1
     IPR011650 Peptidase_M20_dimer
     IPR001261 ArgE/DapE_CS
     IPR002933 Peptidase_M20

    Graphical View of Domain Structure for InterPro Entry Q96KN2

    ProtoNet protein and cluster: Q96KN2

    2 Blocks protein domains:
    IPB001261 ArgE/dapE/ACY1/CPG2/yscS
    IPB011650 Peptidase dimerisation


    UniProtKB/Swiss-Prot: CNDP1_HUMAN, Q96KN2
    Similarity: Belongs to the peptidase M20A family


    Find genes that share domains with CNDP1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CNDP1_HUMAN, Q96KN2
    Catalytic activity: Preferential hydrolysis of the beta-Ala- -His dipeptide (carnosine), and also anserine, Xaa-
    -His dipeptides and other dipeptides including homocarnosine
    Enzyme regulation: Inhibited by the metal chelator 1,10-o-phenantrolin. The inhibitory concentration 50% (IC(50))
    is 5 uM
    Biophysicochemical properties: Kinetic parameters: KM=1.27 uM for carnosine (at 30 degrees Celsius and in the
    absence of cadmium ions); KM=11.00 uM for carnosine (at 30 degrees Celsius and in the presence of 200 uM cadmium
    ions); KM=0.20 uM for homocarnosine (at 30 degrees Celsius and in the absence of cadmium ions); KM=1.0 uM for
    homocarnosine (at 30 degrees Celsius and in the presence of 200 uM cadmium ions); Note=1 hour incubation in 50 mM
    Tris-HCl, pH 7.5; pH dependence: Optimum pH is 8.5;

         Enzyme Number (IUBMB): EC 3.4.13.201

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004180carboxypeptidase activity IEA--
    GO:0008237metallopeptidase activity IEA--
    GO:0016787hydrolase activity ----
    GO:0016805dipeptidase activity IEA--
    GO:0034701tripeptidase activity IEA--
         
    Find genes that share ontologies with CNDP1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for CNDP1:
     Decreased viability with pacli 

         1 MGI phenotypic allele for Cndp1 (no phenotypes)

    Find genes that share phenotypes with CNDP1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Cndp1tm1Lex for CNDP1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CNDP1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CNDP1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CNDP1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CNDP1

    miRNA
    Products:
        
    miRTarBase miRNAs that target CNDP1:
    hsa-mir-335-5p (MIRT018796)

    Block miRNA regulation of human, mouse, rat CNDP1 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate CNDP1:
    hsa-miR-641 hsa-miR-3617
    SwitchGear 3'UTR luciferase reporter plasmidCNDP1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CNDP1
    Predesigned siRNA for gene silencing in human, mouse, rat CNDP1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CNDP1

    Clone
    Products:
         
    OriGene clones in human, mouse for CNDP1 (see all 8)
    OriGene ORF clones in mouse, rat for CNDP1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CNDP1 (NM_032649)
    Sino Biological Human cDNA Clone for CNDP1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CNDP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CNDP1
    Addgene plasmids for CNDP1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CNDP1
    Browse ESI BIO Cell Lines and PureStem Progenitors for CNDP1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CNDP1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    CNDP1_HUMAN, Q96KN2: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    endoplasmic reticulum2
    peroxisome1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--

    Find genes that share ontologies with CNDP1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for CNDP1 About    
    See pathways by source

    SuperPathContained pathways About
    1Metabolism
    Metabolic pathways0.38
    2Histidine metabolism
    Histidine metabolism
    3Beta alanine metabolism
    Beta alanine metabolism
    4beta-Alanine metabolism
    beta-Alanine metabolism
    5Arginine and proline metabolism
    Arginine and proline metabolism


    Find genes that share SuperPaths with CNDP1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for CNDP1
        Beta-alanine metabolism



    4 Kegg Pathways  (Kegg details for CNDP1):
        Arginine and proline metabolism
    Histidine metabolism
    beta-Alanine metabolism
    Metabolic pathways

        Pathway & Disease-focused RT2 Profiler PCR Array including CNDP1: 
              Amino Acid Metabolism II in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CNDP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CNDP1 (ENSP000003516824) via UniProtKB, MINT, STRING, and/or I2D (see all 43)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ABATENSP000002682514STRING: ENSP00000268251
    CARNS1ENSP000003082684STRING: ENSP00000308268
    GAD2ENSP000002592714STRING: ENSP00000259271
    HALENSP000002612084STRING: ENSP00000261208
    HDCENSP000002678454STRING: ENSP00000267845
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis ----
    GO:0008152metabolic process ----

    Find genes that share ontologies with CNDP1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CNDP1

    10 HMDB Compounds for CNDP1    About this table
    CompoundSynonyms CAS #PubMed Ids
    1-Methylhistidine1 methylhistidine (see all 9)332-80-97375183
    3-Methylhistidine3-methyl-L-histidine (see all 13)368-16-1--
    AnserineAnserine (see all 7)584-85-0--
    Beta-Alanine2-Carboxyethylamine (see all 21)107-95-9--
    CadmiumCd (see all 6)7440-43-9--
    CarnosineBeta-Alanyl-L-histidine (see all 14)305-84-0--
    Citric acid2-Hydroxy-1,2,3-propanetricarboxylate (see all 20)77-92-9--
    HomocarnosineHomocarnosine (see all 8)3650-73-5--
    L-Histidine(S)-1H-Imidazole-4-alanine (see all 20)71-00-1--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    1 Novoseek inferred chemical compound relationship for CNDP1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    carnosine 89.7 8 19915793 (2), 16965804 (1), 17205963 (1), 19368810 (1)



    Find genes that share compounds with CNDP1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for CNDP1 gene: 
    NM_032649.5  

    Unigene Cluster for CNDP1:

    Carnosine dipeptidase 1 (metallopeptidase M20 family)
    Hs.400613  [show with all ESTs]
    Unigene Representative Sequence: AK131263
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000358821(uc002llq.3) ENST00000585136 ENST00000582365 ENST00000584316
    ENST00000584004(uc002lls.3) ENST00000578498 ENST00000582461
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CNDP1 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate CNDP1:
    hsa-miR-641 hsa-miR-3617
    SwitchGear 3'UTR luciferase reporter plasmidCNDP1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CNDP1
    Predesigned siRNA for gene silencing in human, mouse, rat CNDP1
    Clone
    Products:
         
    OriGene clones in human, mouse for CNDP1 (see all 8)
    OriGene ORF clones in mouse, rat for CNDP1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CNDP1 (NM_032649)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CNDP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CNDP1
    Addgene plasmids for CNDP1 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CNDP1
    OriGene qSTAR qPCR primer pairs in human, mouse for CNDP1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CNDP1
      QuantiTect SYBR Green Assays in human, mouse, rat CNDP1
      QuantiFast Probe-based Assays in human, mouse, rat CNDP1

    Additional mRNA sequence: 

    AJ417564.1 AK098369.1 AK131263.1 AK289916.1 AK303708.1 AK308716.1 AK314572.1 AY358756.1 
    BC110295.1 BC113512.1 BC117122.1 

    8 DOTS entries:

    DT.40230611  DT.405005  DT.121096529  DT.97797211  DT.121096558  DT.121096564  DT.95181016  DT.95181018 

    Selected AceView cDNA sequences (see all 81):

    AV725146 AI361251 CR610360 BI600248 BX432016 AI480056 BP349556 AY358756 
    AI422476 AW026198 BI821574 BM669584 AI911546 BI667149 BE386547 BM698797 
    BC004271 BX094414 BI754224 BX453730 BI489822 BI489508 BE386438 NM_032649 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CNDP1 (see all 6)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b
    SP1:                                            -                       -     -                                       
    SP2:                                -           -                       -                                             
    SP3:                    -     -     -           -                                                                     
    SP4:                                                                    -     -                                       
    SP5:              -                                                                                                   


    ECgene alternative splicing isoforms for CNDP1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    CNDP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACTCTAGGAC
    CNDP1 Expression
    About this image


    CNDP1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebral Cortex
     
     Kidney (Urinary System)
             Metanephros
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Adipose (Muscoskeletal System)
             Visceral White Adipocytes Visceral White Adipose
     
     Liver (Hepatobiliary System)
    CNDP1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CNDP1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.400613

    UniProtKB/Swiss-Prot: CNDP1_HUMAN, Q96KN2
    Tissue specificity: Found in serum and adult nervous central system. Absent in serum from patients with
    homocarnosinosis

        Pathway & Disease-focused RT2 Profiler PCR Array including CNDP1: 
              Amino Acid Metabolism II in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CNDP1
    OriGene qSTAR qPCR primer pairs in human, mouse for CNDP1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CNDP1
    QuantiTect SYBR Green Assays in human, mouse, rat CNDP1
    QuantiFast Probe-based Assays in human, mouse, rat CNDP1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CNDP1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for CNDP1 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cndp11 , 5 carnosine dipeptidase 1 (metallopeptidase M20 family)1, 5 80.77(n)1
    81.54(a)1
      18 (57.53 cM)5
    3384031  NM_177450.41  NP_803233.21 
     846105095 
    chicken
    (Gallus gallus)
    Aves CNDP11 carnosine dipeptidase 1 (metallopeptidase M20 family) 67.57(n)
    66.53(a)
      421012  XM_004935199.1  XP_004935256.1 
    lizard
    (Anolis carolinensis)
    Reptilia CNDP16
    carnosine dipeptidase 1 (metallopeptidase M20 fami...
    62(a)
    1 ↔ 1
    4(49231635-49258162)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC685632 hypothetical protein MGC68563 73.16(n)    BC060450.1 
    zebrafish
    (Danio rerio)
    Actinopterygii CNDP16
    carnosine dipeptidase 1 (metallopeptidase M20 fami...
    50(a)
    1 ↔ 1
    16(58528592-58552859) ENSDARG00000069583
    fruit fly
    (Drosophila melanogaster)
    Insecta CG173376
    --
    49(a)
    1 → many
    2R(1585359-1587717)
    worm
    (Caenorhabditis elegans)
    Secernentea pes-96
    Y71H2AM.116
    Protein PES-9 (pes-9) mRNA, complete cds
    Protein Y71H2AM.11 (Y71H2AM.11) mRNA, complete cds...
    47(a)
    45(a)
    many ↔ many
    many ↔ many
    V(14595268-14597067) WBGene00003982
    III(2718158-2725092) WBGene00022176
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes DUG2(YBR281C)4 Probable di- and tri-peptidase; forms a complex with more   --   2(767606-764970) 852584  NP_009840.1 


    ENSEMBL Gene Tree for CNDP1 (if available)
    TreeFam Gene Tree for CNDP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for CNDP1 gene
    CNDP22  
    2 SIMAP similar genes for CNDP1 using alignment to 3 protein entries:     CNDP1_HUMAN (see all proteins):
    FLJ00064    CNDP2

    Find genes that share paralogs with CNDP1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Polymorphic Variants from UniProtKB/Swiss-Prot
    CNDP1_HUMAN, Q96KN2: The number of trinucleotide (CTG) repeat varies among different alleles leading to insertion of Leu
    residues in the signal peptide. The allele with 5 leucines (as shown in the reference entry) is known as the
    Mannheim allele. Diabetic patients with the CNDP1 Mannheim allele are less susceptible for nephropathy


    Selected SNPs for CNDP1 (see all 1397)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 18 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs786637271,2
    C--68932563(+) ATCTTA/TAGATA 1 -- us2k10--------
    rs560198001,2
    C--68969567(+) ATAAT-/AATAATA 1 -- int10--------
    rs559404521,2
    C--68983504(+) CAAAT-/GTT   
      T
    /TGTT
    ATTTA
    1 -- int10--------
    rs1399110571,2
    --72053337(+) CGCCCA/GTGCGC 1 -- us2k10--------
    rs1858856441,2
    --72053383(+) GGCAAG/TGTTTT 1 -- us2k10--------
    rs765461091,2
    C,F--72053397(+) CTGATG/AACTGC 1 -- us2k11Minor allele frequency- A:0.19WA 118
    rs1898097531,2
    --72053478(+) TCCAGC/TCCTCG 1 -- us2k10--------
    rs1417899521,2
    --72053632(+) AGAGAC/TGCAGC 1 -- us2k10--------
    rs581345551,2
    C,F--72053647(+) GGAGAC/TGCTGC 1 -- us2k11Minor allele frequency- T:0.19WA 118
    rs1459340191,2
    C--72053672(+) AGGGG-/GCCCCGG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CNDP1 (72201675 - 72254448 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for CNDP1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv909921CNV Gain21882294
    nsv909920CNV Gain21882294
    nsv909919CNV Gain21882294

    Human Gene Mutation Database (HGMD): CNDP1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CNDP1
    DNA2.0 Custom Variant and Variant Library Synthesis for CNDP1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 609064    OMIM disorders: --

    2 diseases for CNDP1:    
    About MalaCards
    homocarnosinosis    diabetic nephropathy

    1 disease from the University of Copenhagen DISEASES database for CNDP1:
    Homocarnosinosis

    Find genes that share disorders with CNDP1           About GenesLikeMe

    4 Novoseek inferred disease relationships for CNDP1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    diabetic nephropathies 79.1 17 20332346 (3), 18753673 (3), 19373489 (3), 17601992 (1) (see all 10)
    renal disease 41.8 6 16046297 (3), 17205963 (2)
    renal failure chronic 40.3 1 17205963 (1)
    diabetes mellitus 13 1 17205963 (1)

    Genetic Association Database (GAD): CNDP1
    Human Genome Epidemiology (HuGE) Navigator: CNDP1 (18 documents)

    Export disorders for CNDP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for CNDP1 gene, integrated from 10 sources (see all 47):
    (articles sorted by number of sources associating them with CNDP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Carnosine as a protective factor in diabetic nephropathy: association with a leucine repeat of the carnosinase gene CNDP1. (PubMed id 16046297)1, 2, 4, 9 Janssen B.... van der Woude F.J. (Diabetes 2005)
    2. Sequence identification and characterization of human carnosinase and a closely related non-specific dipeptidase. (PubMed id 12473676)1, 2, 3 Teufel M....Smirnova T. (J. Biol. Chem. 2003)
    3. A leucine repeat in the carnosinase gene CNDP1 is associated with diabetic end-stage renal disease in European Americans. (PubMed id 17205963)1, 4, 9 Freedman B.I....Bowden D.W. (Nephrol. Dial. Transplant. 2007)
    4. Association between CNDP1 genotype and diabetic nephropathy is sex specific. (PubMed id 20332346)1, 4, 9 Mooyaart A.L....De Heer E. (Diabetes 2010)
    5. The influence of carnosinase gene polymorphisms on diabetic nephropathy risk in African-Americans. (PubMed id 19373489)1, 4, 9 McDonough C.W....Bowden D.W. (Hum. Genet. 2009)
    6. Lower frequency of the 5/5 homozygous CNDP1 genotype in South Asian Surinamese. (PubMed id 19577318)1, 4, 9 Mooyaart A.L....de Heer E. (Diabetes Res. Clin. Pract. 2009)
    7. Allelic variation in the CNDP1 gene and its lack of association with longevity and coronary heart disease. (PubMed id 16965804)1, 4, 9 Zschocke J....Schreiber S. (Mech. Ageing Dev. 2006)
    8. Exclusion of polymorphisms in carnosinase genes (CNDP1 and CNDP2) as a cause of diabetic nephropathy in type 1 diabetes: results of large case-control and follow-up studies. (PubMed id 18753673)1, 4, 9 Wanic K....Krolewski A.S. (Diabetes 2008)
    9. Anserine inhibits carnosine degradation but in human serum carnosinase (CN1) is not correlated with histidine dipeptide concentration. (PubMed id 20971102)1, 4 Peters V....KAPppel H. ( international journal of clinical chemistry 2011)
    10. Examination of association with candidate genes for diabetic nephropathy in a Mexican American population. (PubMed id 20299368)1, 4 Kim S....Adler S.G. (Clin J Am Soc Nephrol 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 84735 HGNC: 20675 AceView: CNDP1 Ensembl:ENSG00000150656 euGenes: HUgn84735
    ECgene: CNDP1 Kegg: 84735 H-InvDB: CNDP1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for CNDP1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for CNDP1 gene:
    Search GeneIP for patents involving CNDP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Antibodies for CNDP1 (Carnosine Dipeptidase 1/CNDP1)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Recombinant/Natural Proteins for CNDP1 (Carnosine Dipeptidase 1/CNDP1)   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for CNDP1   OriGene RNAi products in human, mouse, rat for CNDP1  
     OriGene qPCR primer pairs and template standards for CNDP1   OriGene Protein Over-expression Lysate for CNDP1  
     OriGene MassSpec something-or-other for CNDP1   OriGene clones in human, mouse for CNDP1  
     OriGene qSTAR qPCR primer pairs in human, mouse for CNDP1   OriGene Purified Protein for CNDP1  
     OriGene ORF clones in mouse, rat for CNDP1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CNDP1   OriGene Custom Protein Services for CNDP1  

     
     
     Block miRNA regulation of human, mouse, rat CNDP1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing CNDP1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CNDP1 Predesigned siRNA for gene silencing in human, mouse, rat CNDP1
     QuantiFast Probe-based Assays in human, mouse, rat CNDP1 QuantiTect SYBR Green Assays in human, mouse, rat CNDP1
     PCR Arrays including human, mouse, rat CNDP1 Search Chromatin IP Primers for CNDP1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CNDP1  GeneGlobe Interaction Network for CNDP1
     Regulatory tfbs in CNDP1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for CNDP1 GenScript cDNA clones with any tag delivered in your preferred vector for CNDP1
     GenScript Custom Assay Services for CNDP1 GenScript Custom overexpressing Cell Line Services for CNDP1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for CNDP1
     Proteins for CNDP1
     Cell Lysates for CNDP1
     cDNA Clones for CNDP1
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     CNDP1 antibodies
     CNDP1 proteins
     CNDP1 lysates
     Antibodies for CNDP1
     See all of Abcam's Antibodies, Kits and Proteins for CNDP1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for CNDP1
     Antibodies for CNDP1
     ELISAs for CNDP1
     CLIAs for CNDP1



     Browse ESI BIO Cell Lines and PureStem Progenitors for CNDP1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CNDP1
     SwitchGear 3'UTR luciferase reporter plasmids for CNDP1
     SwitchGear Promoter luciferase reporter plasmids for CNDP1
     ThermoFisher Antibody for CNDP1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CNDP1
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CNDP1
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CNDP1
     LSBio Antibodies in human, mouse, rat for CNDP1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Addgene plasmids for CNDP1
      Search eBioscience for proteins for CNDP1
      Search eBioscience for elisas for CNDP1
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      CNDP1 gene at Home site.
    Version: 3.12.212 17 Sep 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4