CNC Locus
genetic locus GIFtS: 13
GCID: GC02U990015
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Carney complex, multiple neoplasia and lentiginosis
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Aliases
for CNC gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
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| Aliases |
|---|
| Carney Complex, Multiple Neoplasia And Lentiginosis1 2 | | CNC21 2 5 |
Export aliases for CNC gene to outside databases |
Summaries
for CNC gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
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Genomic Views
for CNC gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for CNC
Other transcription factors
Search SABiosciences Chromatin IP Primers for CNC
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CNC |
Genomic Location:
Chromosome:2
Entrez Gene cytogenetic band: 2p16 HGNC cytogenetic band: 2p16GeneLoc information about chromosome 2 |
Proteins
for CNC gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
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UniProtKB: --
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Protein
Domains /
Families
for CNC gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
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Function
for CNC gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
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Pathways & Interactions
for CNC gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
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Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CNC
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Drugs & Compounds
for CNC gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
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CNC for compounds About GeneDecksing
 Browse Tocris compounds for CNC
1 Novoseek chemical compound relationship for CNC gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| cyclic amp |
18.4 |
5 |
18241045 (1), 17079485 (1) |
Search CenterWatch for drugs/clinical trials and news about CNC 
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Transcripts
for CNC gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
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Expression
for CNC gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| See probesets specificity/sensitivity at GeneAnnot
CGAP TAG: --
SABiosciences Custom PCR Arrays for CNC
Primer
Products: |  | Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat CNC | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CNC | | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CNC |
Orthologs
for CNC gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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Paralogs
for CNC gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
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Genomic Variants
for CNC gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
| | SABiosciences Cancer Mutation PCR Assays |
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Disorders
/ Diseases
for CNC gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
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CNC for disorders About GeneDecksing
OMIM gene information: 605244
OMIM disorders: --
20/27  diseases for CNC (see all 27): About MalaCardscarney complex peutz-jeghers syndrome von hippel-lindau disease primary pigmented nodular adrenocortical disease
multiple endocrine neoplasia ectopic thymus odontogenic myxoma adrenal hyperplasia
cowden disease adrenal adenoma myxoma pituitary adenoma
ovarian cyst cushing's syndrome adenoma pituitary tumor
male infertility acromegaly thyroid adenoma adrenocortical tumor
10/24 Novoseek disease relationships for CNC gene (see all 24) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| lentigo |
91.7 |
10 |
11595829 (1), 10084605 (1), 16192737 (1), 17322955 (1) (see all 10) |
| myxoma |
88.8 |
38 |
10973256 (2), 16001434 (2), 19494712 (2), 19650827 (2) (see all 25) |
| multiple endocrine neoplasia type 1 |
84.4 |
20 |
15761655 (3), 18990538 (1), 19153518 (1), 16625848 (1) (see all 18) |
| multiple endocrine neoplasia |
84.1 |
17 |
12144681 (1), 15163302 (1), 15761532 (1), 11595829 (1) (see all 17) |
| lentigines |
81.1 |
4 |
15761532 (1), 11595829 (1), 12666684 (1), 18804312 (1) |
| cushing syndrome |
75.3 |
21 |
16192737 (4), 16756677 (2), 15163302 (1), 15761532 (1) (see all 13) |
| adrenal hyperplasia |
75.1 |
3 |
15163302 (1), 18549891 (1), 19915019 (1) |
| pituitary tumors |
74.3 |
11 |
17001464 (3), 11061550 (2), 15281351 (2), 15921845 (1) (see all 7) |
| pituitary adenoma |
70.2 |
16 |
19522822 (2), 17993773 (2), 17893250 (2), 17914118 (2) (see all 11) |
| peutz-jeghers syndrome |
69.8 |
6 |
12144681 (1), 11595829 (1), 19737912 (1), 11095480 (1) (see all 5) |
Export disorders for CNC gene to outside databases
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Publications
for CNC gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
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PubMed articles for CNC gene, integrated from 9 sources (see all 81):
(articles sorted by number of sources associating them with CNC) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Carney complex, a familial multiple neoplasia and lentiginosis syndrome. Analysis of 11 kindreds and linkage to the short arm of chromosome 2. (PubMed id 8609225)1, 3 Stratakis C.A....Chrousos G.P. (1996)
- Genetic heterogeneity of familial atrial myxoma syndromes (Carney complex). (PubMed id 9104925)1 Basson C.T....Merliss A. (1997)
- Ovarian lesions in Carney complex: clinical genetics and possible predisposition to malignancy. (PubMed id 11095480)9 Stratakis C.A....Carney J.A. (2000)
- Carney complex (CNC). (PubMed id 16756677)9 Bertherat J. (2006)
- Pituitary pathology in Carney complex patients. (PubMed id 15761655)9 Stergiopoulos S.G....Stratakis C.A. (2004)
- Carney complex and lentiginosis. (PubMed id 19650827)9 Horvath A. and Stratakis C.A. (2009)
- Adrenal pathophysiology: lessons from the Carney complex. (PubMed id 16192737)9 Groussin L....Bertherat J. (2005)
- Protein kinase A and its role in human neoplasia: the Carney complex paradigm. (PubMed id 15163302)9 Bossis I....Stratakis C.A. (2004)
- Mutations of the gene encoding the protein kinase A type I-alpha regulatory subunit in patients with the Carney complex. (PubMed id 10973256)9 Kirschner L.S....Stratakis C.A. (2000)
- Genetic and histologic studies of somatomammotropic pituitary tumors in patients with the 'complex of spotty skin pigmentation, myxomas, endocrine overactivity and schwannomas' (Carney complex). (PubMed id 11061550)9 Pack S.D....Stratakis C.A. (2000)
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External Searches for CNC gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing CNC gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
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Other Databases showing CNC gene
(According to HUGE)
About This Section
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Specialized Databases showing CNC gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
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| Name | Description |
| PharmGKB entry for CNC | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for CNC gene:
Search GeneIP for patents involving CNC
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for CNC gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CNC | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CNC | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CNC | | | Search QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CNC | | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CNC | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CNC |
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| | | | Search Tocris compounds for CNC |
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 | | | | |  |  |  | | | | Search ThermoFisher Antibodies for CNC |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat CNC |
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