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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CNBP Gene

protein-coding   GIFtS: 55
GCID: GC03M128886

CCHC-Type Zinc Finger, Nucleic Acid Binding Protein

(Previous names: zinc finger protein 9 (a cellular retroviral nucleic acid...)
(Previous symbols: DM2, ZNF9)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
CCHC-Type Zinc Finger, Nucleic Acid Binding Protein1 2     PROMM2 5
ZNF91 2 3 5     ZCCHC222
DM21 2 5     Cellular Nucleic Acid Binding Protein2
Zinc Finger Protein 9 (A Cellular Retroviral Nucleic Acid Binding Protein)1 2     Cellular Nucleic Acid-Binding Protein2
Zinc Finger Protein 91 3     Erythroid Differentiation-Related2
RNF1632 3     Sterol Regulatory Element-Binding Protein2
CNBP12 5     Zinc Finger Protein 2732

External Ids:    HGNC: 131641   Entrez Gene: 75552   Ensembl: ENSG000001697147   OMIM: 1169555   UniProtKB: P626333   

Export aliases for CNBP gene to outside databases

Previous GC identifers: GC03M130372 GC03M126273


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CNBP Gene:
This gene encodes a nucleic-acid binding protein with seven zinc-finger domains. The protein has a preference for
binding single stranded DNA and RNA. The protein functions in cap-independent translation of ornithine
decarboxylase mRNA, and may also function in sterol-mediated transcriptional regulation. A CCTG expansion in the
first intron of this gene results in myotonic dystrophy type 2. Multiple transcript variants encoding different
isoforms have been found for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for CNBP Gene: 
CNBP (CCHC-type zinc finger, nucleic acid binding protein) is a protein-coding gene. Diseases associated with CNBP include myotonic dystrophy type 2, and nondystrophic myotonia. GO annotations related to this gene include DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ZCCHC13.

UniProtKB/Swiss-Prot: CNBP_HUMAN, P62633
Function: Single stranded DNA-binding protein, with specificity to the sterol regulatory element (SRE). Involved
in sterol-mediated repression

Gene Wiki entry for CNBP Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NT_005612.16  NC_018914.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CNBP gene promoter:
         USF1   RREB-1   NF-AT   CREB   NF-AT4   Ik-2   NF-AT2   USF-1   NF-AT3   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCNBP promoter sequence
   Search SABiosciences Chromatin IP Primers for CNBP

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CNBP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q21   Ensembl cytogenetic band:  3q21.3   HGNC cytogenetic band: 3q21

CNBP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CNBP gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M128886:  view genomic region     (about GC identifiers)

Start:
128,886,658 bp from pter      End:
128,902,810 bp from pter
Size:
16,153 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CNBP_HUMAN, P62633 (See protein sequence)
Recommended Name: Cellular nucleic acid-binding protein  
Size: 177 amino acids; 19463 Da
Subcellular location: Cytoplasm (By similarity). Endoplasmic reticulum (By similarity)
Secondary accessions: A8K7V4 B2RAV9 D3DNB9 D3DNC0 D3DNC1 E9PDR7 P20694 Q4JGY0 Q5QJR0 Q5U0E9
Q6PJI7 Q96NV3
Alternative splicing: 6 isoforms:  P62633-1   P62633-2   P62633-3   P62633-4   P62633-5   P62633-6   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CNBP: NX_P62633

Explore proteomics data for CNBP at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P62633

  • CNBP Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CNBP Protein Expression
    REFSEQ proteins (6 alternative transcripts): 
    NP_001120664.1  NP_001120665.1  NP_001120666.1  NP_001120667.1  NP_001120668.1  NP_003409.1  

    ENSEMBL proteins: 
     ENSP00000421323   ENSP00000410619   ENSP00000399488   ENSP00000400444   ENSP00000426223  
     ENSP00000422110   ENSP00000410769   ENSP00000424787  

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    Novus Biologicals CNBP Proteins
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    ProSpec Recombinant Protein for CNBP
    Cloud-Clone Corp. Proteins for CNBP 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634NOT nucleus ISS--
    GO:0005783endoplasmic reticulum ISS--
    GO:0005829cytosol ISS--

    CNBP for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZCCHC: Zinc fingers, CCHC domain containing
    RNF: RING-type (C3HC4) zinc fingers

    1 InterPro protein domain:
     IPR001878 Znf_CCHC

    Graphical View of Domain Structure for InterPro Entry P62633

    ProtoNet protein and cluster: P62633

    UniProtKB/Swiss-Prot: CNBP_HUMAN, P62633
    Similarity: Contains 7 CCHC-type zinc fingers


    CNBP for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CNBP_HUMAN, P62633
    Function: Single stranded DNA-binding protein, with specificity to the sterol regulatory element (SRE). Involved
    in sterol-mediated repression

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding ----
    GO:0003697single-stranded DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity TAS2562787
    GO:0003727single-stranded RNA binding IEA--
         
    CNBP for ontologies           About GeneDecksing


    Phenotypes:
         8 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Cnbp):
     cellular  craniofacial  embryogenesis  growth/size  mortality/aging 
     nervous system  skeleton  vision/eye 

    CNBP for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for CNBP 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CNBP

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CNBP 
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    hsa-miR-124* hsa-miR-323-3p hsa-miR-193a-3p hsa-miR-300 hsa-miR-3146 hsa-miR-376b hsa-miR-138-2* hsa-miR-3921
    SwitchGear 3'UTR luciferase reporter plasmidCNBP 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CNBP


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CNBP

    5/484 Interacting proteins for CNBP (P626333) via UniProtKB, MINT, STRING, and/or I2D (see all 484)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=2 
    HIST1H4BP628053I2D: score=2 
    HIST1H4CP628053I2D: score=2 
    HIST1H4DP628053I2D: score=2 
    HIST1H4EP628053I2D: score=2 
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent TAS2562787
    GO:0006695cholesterol biosynthetic process TAS2562787
    GO:0008284positive regulation of cell proliferation ISS--
    GO:0045893positive regulation of transcription, DNA-dependent ISS--

    CNBP for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CNBP for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CNBP

    8 Novoseek inferred chemical compound relationships for CNBP gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    zinc 62.8 52 2253775 (2), 1515675 (1), 7531280 (1), 16265841 (1) (see all 34)
    poly c 36.8 1 7607214 (1)
    sterol 23 5 10617772 (1), 1718676 (1), 7721877 (1)
    arginine 17.9 6 15364944 (1), 17166179 (1), 19365714 (1), 12678849 (1) (see all 5)
    phenol 7.4 1 1837060 (1)
    agarose 3.4 2 18925718 (1), 12398195 (1)
    cholesterol 0 4 10617772 (1), 7896846 (1), 2253775 (1)
    atp 0 1 7574500 (1)

    Search CenterWatch for drugs/clinical trials and news about CNBP

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CNBP gene (6 alternative transcripts): 
    NM_001127192.1  NM_001127193.1  NM_001127194.1  NM_001127195.1  NM_001127196.1  NM_003418.4  

    Unigene Cluster for CNBP:

    CCHC-type zinc finger, nucleic acid binding protein
    Hs.518249  [show with all ESTs]
    Unigene Representative Sequence: NM_001127192
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000502976 ENST00000422453(uc003elr.4 uc003elq.4 uc021xdv.1 uc021xdw.1 uc011bku.2)
    ENST00000451728(uc021xdu.1) ENST00000446936(uc021xdt.1) ENST00000500450
    ENST00000504813 ENST00000441626 ENST00000502372 ENST00000512338 ENST00000507573

    miRNA
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    hsa-miR-124* hsa-miR-323-3p hsa-miR-193a-3p hsa-miR-300 hsa-miR-3146 hsa-miR-376b hsa-miR-138-2* hsa-miR-3921
    SwitchGear 3'UTR luciferase reporter plasmidCNBP 3' UTR sequence
    Inhib. RNA
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CNBP
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CNBP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CNBP
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    Additional mRNA sequence: 

    AK021693.1 AK054592.1 AK292119.1 AK298154.1 AK314380.1 AY436367.1 BC000288.2 BC014911.1 
    BC093058.1 BT019613.1 DQ091187.1 DQ092366.1 DQ092367.1 M28372.1 

    24/51 DOTS entries (see all 51):

    DT.100879373  DT.100879362  DT.101959009  DT.100830932  DT.100879387  DT.100879388  DT.92465693  DT.100879357 
    DT.100879366  DT.100879386  DT.100879389  DT.100879365  DT.91983551  DT.100758237  DT.97866200  DT.92465710 
    DT.100838677  DT.407425  DT.120857803  DT.100879383  DT.120857562  DT.100879374  DT.120857725  DT.120857754 

    24/1000 AceView cDNA sequences (see all 1000):

    AI682386 CR615983 CR608484 BU902517 CR616385 BC014911 BM662151 CR599232 
    CB215312 AW162036 BM781496 CR602369 CR608775 BM460631 BU630334 AI952921 
    BU173733 AI886373 CD365552 BM541323 AI679309 AK054592 BQ670299 CR606309 

    GeneLoc Exon Structure

    5/17 Alternative Splicing Database (ASD) splice patterns (SP) for CNBP (see all 17)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7a · 7b · 7c · 7d · 7e · 7f · 7g ·
    SP1:                                      -     -                                   -                 -                                                         
    SP2:                                      -     -                                   -                                                                           
    SP3:                                -     -     -                                   -                                                                           
    SP4:                                      -     -                 -                 -                                                                           
    SP5:                                      -     -                       -           -                                                                           

    ExUns: 7h · 7i
    SP1:            
    SP2:            
    SP3:            
    SP4:            
    SP5:            


    ECgene alternative splicing isoforms for CNBP

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CNBP expression in normal human tissues (normalized intensities)      CNBP embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CGTGTTAATG
    CNBP Expression
    About this image


    CNBP expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/5 selected tissues (see all 5) fully expand
     
     Intermediate Mesoderm (Gastrulation Derivatives)    fully expand to see all 2 entries
             Mesonephric cells Mesonephros
             Mesonephros
     
     Kidney (Urinary System)
             Metanephros
     
     Gonad
             Mesonephric cells Mesonephros
     
     Testis (Reproductive System)
     
     Ovary (Reproductive System)

    See CNBP Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CNBP

    SOURCE GeneReport for Unigene cluster: Hs.518249

    UniProtKB/Swiss-Prot: CNBP_HUMAN, P62633
    Tissue specificity: Present in all tissues examined

        SABiosciences Expression via Pathway-Focused PCR Arrays including CNBP: 
              Insulin Resistance in human mouse rat
              Lipoprotein Signaling & Cholesterol Metabolism in human mouse rat
              Fatty Liver in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CNBP

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for CNBP gene from 7/20 species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cnbp1 , 5 cellular nucleic acid binding protein1, 5 94.74(n)1
    100(a)1
      6 (39.13 cM)5
    127851  NM_001109745.11  NP_001103215.11 
     878430825 
    chicken
    (Gallus gallus)
    Aves CNBP1 CCHC-type zinc finger, nucleic acid binding protein 90.64(n)
    97.66(a)
      395731  NM_204907.1  NP_990238.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.9852 Xenopus laevis cellular nucleic acid binding protein more 84.44(n)    U20977.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufe36b092 wufe36b09 80.04(n)   326846  BC056793.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG38001 CG3800 53.56(n)
    47.59(a)
      37646  NM_137895.2  NP_611739.1 
    worm
    (Caenorhabditis elegans)
    Secernentea K08D12.36
    Protein K08D12.3, isoform a
    34(a)
    1 → many
    IV(1710258-1711141)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes GIS21 Gis2p 55.26(n)
    47.37(a)
      855466   NP_014144.1 


    ENSEMBL Gene Tree for CNBP (if available)
    TreeFam Gene Tree for CNBP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CNBP gene
    ZCCHC132  
    2 SIMAP similar genes for CNBP using alignment to 3 protein entries:     CNBP_HUMAN (see all proteins):
    ZNF9    ZCCHC13

    CNBP for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/495 SNPs in CNBP are shown (see all 495)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1394520101,2
    C--128869708(+) AAGGAA/GCACTT 6 -- ds50010--------
    rs98753921,2
    C,F,A,H--128869725(+) CTCCTA/GTGAAT 6 -- ds500123Minor allele frequency- G:0.18NS EA NA WA CSA 2351
    rs1823626971,2
    --128869794(+) CAGCAC/GAAGGA 6 -- ds50010--------
    rs1158727631,2
    C,F--128869806(+) TGGGTG/ACATGA 6 -- ds50011Minor allele frequency- A:0.06WA 118
    rs1453150401,2
    --128869930(+) GAGCCA/GTAACA 6 -- ds50010--------
    rs1476322591,2
    --128869931(+) AGCCAC/TAACAA 6 -- ds50010--------
    rs789224661,2
    F--128870016(+) ACCAGC/ACCCCA 6 -- ds50011Minor allele frequency- A:0.05WA 118
    rs1500145261,2
    C--128870068(+) CCCAA-/CCTAAC 6 -- ds50010--------
    rs1181605271,2
    C,F--128870085(+) GCCTTC/TGAAAA 6 -- ds50011Minor allele frequency- T:0.02EA 120
    rs11330461,2
    C--128870154(-) TTAACA/CCAATA 6 -- ut312Minor allele frequency- C:0.00NA 4

    HapMap Linkage Disequilibrium report for CNBP (128886658 - 128902810 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for CNBP:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv5251n71CNV Loss21882294


    Human Gene Mutation Database (HGMD): CNBP
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CNBP
    DNA2.0 Custom Variant and Variant Library Synthesis for CNBP

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 116955   
    OMIM disorders: 602668  
    UniProtKB/Swiss-Prot: CNBP_HUMAN, P62633
  • Dystrophia myotonica 2 (DM2) [MIM:602668]: A multisystem disease characterized by the association of
    proximal muscle weakness with myotonia, cardiac manifestations and cataract. Additional features can include
    hyperhidrosis, testicular atrophy, insulin resistance and diabetes and central nervous system anomalies in rare
    cases. Note=The disease is caused by mutations affecting the gene represented in this entry. The causative
    mutation is a CCTG expansion (mean approximately 5000 repeats) located in intron 1 of the CNBP gene

  • 20/23 diseases for CNBP (see all 23):    About MalaCards
    myotonic dystrophy type 2    nondystrophic myotonia    prostatic cyst    myotonic dystrophy
    thomsen disease    myotonia    myotonic dystrophy type 1    sleep disorder
    reactive arthritis    fibromyalgia    frontotemporal dementia    dementia
    cataract    myopathy    blindness    insulin resistance
    lupus erythematosus    cervicitis    colon cancer    arthritis

    2 diseases from the University of Copenhagen DISEASES database for CNBP:
    Myotonic dystrophy     Thomsen disease

    CNBP for disorders           About GeneDecksing

    10/13 Novoseek inferred disease relationships for CNBP gene (see all 13)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    myotonic dystrophy 87.5 58 20458885 (2), 16376058 (2), 15652222 (2), 16876389 (1) (see all 27)
    promm 87.4 12 15215218 (1), 12601109 (1), 17395134 (1), 14666402 (1) (see all 6)
    cataract 20.6 2 17395134 (1)
    creutzfeldt-jakob disease 11.2 1 8516321 (1)
    immunodeficiency 8.84 2 12857921 (1), 10593967 (1)
    inflammation 3.37 1 15621569 (1)
    tumors 3 1 16327994 (1)
    lupus erythematosus systemic 0 1 15621569 (1)
    leukemia 0 1 12581738 (1)
    virus infection 0 1 16254365 (1)

    GeneTests: CNBP
    GeneReviews: CNBP
    Genetic Association Database (GAD): CNBP
    Human Genome Epidemiology (HuGE) Navigator: CNBP (3 documents)

    Export disorders for CNBP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CNBP gene, integrated from 9 sources (see all 178):
    (articles sorted by number of sources associating them with CNBP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Myotonic dystrophy type 2 caused by a CCTG expansion in intron 1 of ZNF9. (PubMed id 11486088)1, 2, 3, 9 Liquori C.L....Ranum L.P. (2001)
    2. Organization of the gene encoding cellular nucleic acid-binding protein. (PubMed id 7590281)1, 2, 9 Flink I.L. and Morkin E. (1995)
    3. Mapping of the gene for CNBP, a finger protein, to human chromosome 3q13.3-q24. (PubMed id 2249857)1, 3, 9 Lusis A.J....Sparkes R.S. (1990)
    4. Myotonic dystrophy type 2 found in two of sixty-three persons diagnosed as having fibromyalgia. (PubMed id 18975316)1, 4 Auvinen S....Udd B. (2008)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Identification of a zinc finger protein that binds to the sterol regulatory element. (PubMed id 2562787)1, 2 Rajavashisth T.B.... Lusis A.J. (1989)
    8. Effect of the [CCTG]n repeat expansion on ZNF9 expression in myotonic dystrophy type II (DM2). (PubMed id 16376058)1, 9 Botta A....Loreni F. (2006)
    9. Mouse cellular nucleic acid binding proteins: a highly conserved family identified by genetic mapping and sequencing. (PubMed id 7896269)1, 9 Warden C.H....Lusis A.J. (1994)
    10. DM2 intronic expansions: evidence for CCUG accumulation without flanking sequence or effects on ZNF9 mRNA processing or protein expression. (PubMed id 16624843)1, 9 Margolis J.M....Ranum L.P. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7555 HGNC: 13164 AceView: ZNF9 Ensembl:ENSG00000169714 euGenes: HUgn7555
    ECgene: CNBP H-InvDB: CNBP

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CNBP Pharmacogenomics, SNPs, Pathways
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/CNBP

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CNBP gene:
    Search GeneIP for patents involving CNBP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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