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Aliases for CNBD2 Gene

Aliases for CNBD2 Gene

  • Cyclic Nucleotide Binding Domain Containing 2 2 3
  • Cyclic Nucleotide (CNMP) Binding Domain Containing 1 2 3
  • C20orf152 3 4
  • Chromosome 20 Open Reading Frame 152 2
  • CNMPD1 3

External Ids for CNBD2 Gene

Previous HGNC Symbols for CNBD2 Gene

  • C20orf152
  • CNMPD1

Previous GeneCards Identifiers for CNBD2 Gene

  • GC20P034557

Summaries for CNBD2 Gene

GeneCards Summary for CNBD2 Gene

CNBD2 (Cyclic Nucleotide Binding Domain Containing 2) is a Protein Coding gene. GO annotations related to this gene include cAMP binding.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CNBD2 Gene

Genomics for CNBD2 Gene

Genomic Location for CNBD2 Gene

Chromosome:
20
Start:
35,954,562 bp from pter
End:
36,030,700 bp from pter
Size:
76,139 bases
Orientation:
Plus strand

Genomic View for CNBD2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CNBD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CNBD2 Gene

No data available for Regulatory Elements for CNBD2 Gene

Proteins for CNBD2 Gene

  • Protein details for CNBD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96M20-CNBD2_HUMAN
    Recommended name:
    Cyclic nucleotide-binding domain-containing protein 2
    Protein Accession:
    Q96M20
    Secondary Accessions:
    • Q14C79
    • Q5JWY7
    • Q5T3S1
    • Q9BR36
    • Q9BWY5

    Protein attributes for CNBD2 Gene

    Size:
    576 amino acids
    Molecular mass:
    67512 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CNBD2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CNBD2 Gene

Proteomics data for CNBD2 Gene at MOPED

Post-translational modifications for CNBD2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CNBD2 Gene

Domains & Families for CNBD2 Gene

Protein Domains for CNBD2 Gene

Suggested Antigen Peptide Sequences for CNBD2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96M20

UniProtKB/Swiss-Prot:

CNBD2_HUMAN :
  • Contains 1 cyclic nucleotide-binding domain.
Domain:
  • Contains 1 cyclic nucleotide-binding domain.
genes like me logo Genes that share domains with CNBD2: view

No data available for Gene Families for CNBD2 Gene

Function for CNBD2 Gene

Gene Ontology (GO) - Molecular Function for CNBD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030552 cAMP binding IEA --
genes like me logo Genes that share ontologies with CNBD2: view

Phenotypes for CNBD2 Gene

GenomeRNAi human phenotypes for CNBD2:
genes like me logo Genes that share phenotypes with CNBD2: view

Animal Model Products

miRNA for CNBD2 Gene

miRTarBase miRNAs that target CNBD2

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CNBD2

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for CNBD2 Gene

Localization for CNBD2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CNBD2 Gene COMPARTMENTS Subcellular localization image for CNBD2 gene
Compartment Confidence
cytosol 2

Gene Ontology (GO) - Cellular Components for CNBD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IEA --
genes like me logo Genes that share ontologies with CNBD2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CNBD2 Gene

Pathways & Interactions for CNBD2 Gene

SuperPathways for CNBD2 Gene

No Data Available

Interacting Proteins for CNBD2 Gene

Gene Ontology (GO) - Biological Process for CNBD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007283 spermatogenesis IEA --
genes like me logo Genes that share ontologies with CNBD2: view

No data available for Pathways by source and SIGNOR curated interactions for CNBD2 Gene

Drugs & Compounds for CNBD2 Gene

No Compound Related Data Available

Transcripts for CNBD2 Gene

Unigene Clusters for CNBD2 Gene

Cyclic nucleotide binding domain containing 2:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CNBD2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CNBD2 Gene

No ASD Table

Relevant External Links for CNBD2 Gene

GeneLoc Exon Structure for
CNBD2
ECgene alternative splicing isoforms for
CNBD2

Expression for CNBD2 Gene

mRNA expression in normal human tissues for CNBD2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CNBD2 Gene

This gene is overexpressed in Testis (x40.7).

Protein differential expression in normal tissues from HIPED for CNBD2 Gene

This gene is overexpressed in Pancreatic juice (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CNBD2 Gene



SOURCE GeneReport for Unigene cluster for CNBD2 Gene Hs.732697

genes like me logo Genes that share expression patterns with CNBD2: view

Protein tissue co-expression partners for CNBD2 Gene

- Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for CNBD2 Gene

Orthologs for CNBD2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CNBD2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CNMPD1 35
  • 81.37 (n)
  • 72.93 (a)
CNBD2 36
  • 71 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CNMPD1 35
  • 83.54 (n)
  • 75.57 (a)
CNBD2 36
  • 72 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cnbd2 35
  • 75.78 (n)
  • 66.19 (a)
Cnbd2 16
Cnbd2 36
  • 55 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CNMPD1 35
  • 98.89 (n)
  • 97.73 (a)
CNBD2 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CNBD2 36
  • 45 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CNBD2 36
  • 30 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CNBD2 36
  • 48 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100486705 35
  • 52.97 (n)
  • 44.9 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 22 (a)
OneToOne
Species with no ortholog for CNBD2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CNBD2 Gene

ENSEMBL:
Gene Tree for CNBD2 (if available)
TreeFam:
Gene Tree for CNBD2 (if available)

Paralogs for CNBD2 Gene

(1) SIMAP similar genes for CNBD2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CNBD2: view

No data available for Paralogs for CNBD2 Gene

Variants for CNBD2 Gene

Sequence variations from dbSNP and Humsavar for CNBD2 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs947359 -- 35,982,397(+) CTTGC(C/T)TTCTC intron-variant
rs1341603 -- 35,968,294(-) ACTCC(C/T)ACCAG upstream-variant-2KB, intron-variant
rs1891151 -- 36,024,804(+) gtggc(A/G/T)ggcac intron-variant
rs1891152 -- 36,024,887(+) CCAAG(G/T)TTGCA intron-variant
rs1891153 -- 36,025,141(+) GTGAT(A/C)TAATG intron-variant

Variation tolerance for CNBD2 Gene

Residual Variation Intolerance Score: 96.11% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.18; 93.95% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CNBD2 Gene

HapMap Linkage Disequilibrium report
CNBD2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CNBD2 Gene

Disorders for CNBD2 Gene

Relevant External Links for CNBD2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CNBD2
genes like me logo Genes that share disorders with CNBD2: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CNBD2 Gene

Publications for CNBD2 Gene

  1. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 2 67
  2. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 67
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 67
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 67
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 67

Products for CNBD2 Gene

Sources for CNBD2 Gene

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