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CNBD2 Gene

protein-coding   GIFtS: 32
GCID: GC20P034557

Cyclic Nucleotide Binding Domain Containing 2

(Previous names: chromosome 20 open reading frame 152, cyclic nucleotide...)
(Previous symbols: C20orf152, CNMPD1)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cyclic Nucleotide Binding Domain Containing 21 2     Chromosome 20 Open Reading Frame 1521
C20orf1521 2 3     Cyclic Nucleotide-Binding Domain-Containing Protein 22
CNMPD11 2     dJ954P9.12
Cyclic Nucleotide (CNMP) Binding Domain Containing 11 2     

External Ids:    HGNC: 161451   Entrez Gene: 1408942   Ensembl: ENSG000001496467   UniProtKB: Q96M203   

Export aliases for CNBD2 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CNBD2 Gene:
CNBD2 (cyclic nucleotide binding domain containing 2) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Search for regulatory transcription factor binding sites for CNBD2
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCNBD2 promoter sequence
   Search Chromatin IP Primers for CNBD2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CNBD2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q11.23   Ensembl cytogenetic band:  20q11.23   HGNC cytogenetic band: 20q11.23

CNBD2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CNBD2 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P034557:  view genomic region     (about GC identifiers)

Start:
34,556,512 bp from pter      End:
34,618,622 bp from pter
Size:
62,111 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CNBD2_HUMAN, Q96M20 (See protein sequence)
Recommended Name: Cyclic nucleotide-binding domain-containing protein 2  
Size: 576 amino acids; 67512 Da
Secondary accessions: Q14C79 Q5JWY7 Q5T3S1 Q9BR36 Q9BWY5
Alternative splicing: 3 isoforms:  Q96M20-1   Q96M20-2   Q96M20-3   

Explore the universe of human proteins at neXtProt for CNBD2: NX_Q96M20

Explore proteomics data for CNBD2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CNBD2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001194005.1  NP_543024.2  

    ENSEMBL proteins: 
     ENSP00000363084   ENSP00000340954   ENSP00000476014   ENSP00000442729  

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    antibodies-online proteins for CNBD2 (2 products) 

     
    antibodies-online peptides for CNBD2

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    antibodies-online antibodies for CNBD2 (13 products) 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR018488 cNMP-bd_CS
     IPR018490 cNMP-bd-like
     IPR000595 cNMP-bd_dom
     IPR014710 RmlC-like_jellyroll

    Graphical View of Domain Structure for InterPro Entry Q96M20

    ProtoNet protein and cluster: Q96M20

    1 Blocks protein domain: IPB000595 Cyclic nucleotide-binding domain

    UniProtKB/Swiss-Prot: CNBD2_HUMAN, Q96M20
    Similarity: Contains 1 cyclic nucleotide-binding domain


    Find genes that share domains with CNBD2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for CNBD2

    miRNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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      --

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CNBD2
    Interactions:

        Search GeneGlobe Interaction Network for CNBD2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CNBD2 (ENSP000003409544) via UniProtKB, MINT, STRING, and/or I2D (see all 29)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PHLPP2ENSP000003486114STRING: ENSP00000348611
    PPP6CENSP000003921474STRING: ENSP00000392147
    ANAPC4ENSP000003187754STRING: ENSP00000318775
    HSPA4ENSP000003029614STRING: ENSP00000302961
    HSPA4LENSP000002964644STRING: ENSP00000296464
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CNBD2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CNBD2 gene (2 alternative transcripts): 
    NM_001207076.1  NM_080834.2  

    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000373973 ENST00000349339(uc002xer.1 uc002xes.1 uc010gfp.1)
    ENST00000489667 ENST00000463258 ENST00000538900
    miRNA
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    21 AceView cDNA sequences:

    BC057288 AL844384 AA905322 BX101299 AI191598 NM_080834 AW340269 AI765510 
    BI825283 AL844336 AK057454 AL844348 BC030782 BF439347 CD635973 BX420805 
    BG720749 BG461373 AL844341 AL844446 AL844337 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CNBD2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CNBD2 Expression
    About this image


    CNBD2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Endothelium (Cardiovascular System)
             Endothelial Cells Blood Brain Barrier
     
     Brain (Nervous System)
             Endothelial Cells Blood Brain Barrier
     
     Testis (Reproductive System)
    CNBD2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CNBD2 Protein Expression
        Custom PCR Arrays for CNBD2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CNBD2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CNBD2 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cnbd21 , 5 RIKEN cDNA 4921517L17 gene5
    cyclic nucleotide binding domain containing 21
    75.78(n)1
    66.19(a)1
      2 (77.39 cM)5
    708731  NM_027585.21  NP_081861.21 
     1563122995 
    lizard
    (Anolis carolinensis)
    Reptilia CNBD26
    cyclic nucleotide binding domain containing 2
    48(a)
    1 ↔ 1
    GL343208.1(3466419-3555782)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004867051 cyclic nucleotide-binding domain-containing protein more 52.97(n)
    44.9(a)
      100486705  XM_002942540.2  XP_002942586.2 


    ENSEMBL Gene Tree for CNBD2 (if available)
    TreeFam Gene Tree for CNBD2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CNBD2 gene
    1 SIMAP similar gene for CNBD2 using alignment to 2 protein entries:     CNBD2_HUMAN (see all proteins):
    C20orf152

    Find genes that share paralogs with CNBD2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CNBD2 (see all 1251)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1859790121,2
    --34554529(+) ATTCAA/GTATTT 2 -- us2k10--------
    rs1385269751,2
    C--34554559(+) GTCTTA/CTGTTT 2 -- us2k10--------
    rs1132443501,2
    C--34554572(+) CTGAGT/-TTTTT 2 -- us2k11Minor allele frequency- -:0.50CSA 2
    rs1427784571,2
    C--34554604(+) GACTT-/AATGGG 2 -- us2k10--------
    rs1895920451,2
    --34554611(+) TGGGAC/TAGTAC 2 -- us2k10--------
    rs1403046781,2
    C--34554628(+) CCCACA/GTTCCA 2 -- us2k10--------
    rs60607251,2
    H--34554675(+) GCTAAG/AGTGCT 2 -- us2k14Minor allele frequency- A:0.00NS EA 418
    rs1811336331,2
    --34554799(+) GTGTTG/TTTCTT 2 -- us2k10--------
    rs1869530331,2
    --34554816(+) CCCACG/TTCCTA 2 -- us2k10--------
    rs1434906981,2
    --34554977(+) AAAGTA/GTGCCT 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for CNBD2 (34556512 - 34618622 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for CNBD2: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CNBD2
    DNA2.0 Custom Variant and Variant Library Synthesis for CNBD2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CNBD2 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with CNBD2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2, 3 Deloukas P....Rogers J. (Nature 2001)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 140894 HGNC: 16145 AceView: C20orf152 Ensembl:ENSG00000149646 euGenes: HUgn140894
    ECgene: CNBD2 H-InvDB: CNBD2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CNBD2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CNBD2 gene:
    Search GeneIP for patents involving CNBD2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for CNBD2
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     Browse SwitchGear 3'UTR luciferase reporter plasmids for CNBD2
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     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CNBD2
     Browse compounds at ApexBio
     Search Addgene for plasmids for CNBD2
      Search eBioscience for proteins for CNBD2
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      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for CNBD2
     antibodies-online antibodies for CNBD2 (13 products)
     antibodies-online kits for CNBD2
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

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