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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CNBD2 Gene

protein-coding   GIFtS: 33
GCID: GC20P034557

Cyclic Nucleotide Binding Domain Containing 2

(Previous names: chromosome 20 open reading frame 152, cyclic nucleotide...)
(Previous symbols: C20orf152, CNMPD1)
  Search for CNBD2
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Cyclic Nucleotide Binding Domain Containing 21 2     Chromosome 20 Open Reading Frame 1521
C20orf1521 2 3     Cyclic Nucleotide-Binding Domain-Containing Protein 22
CNMPD11 2     dJ954P9.12
Cyclic Nucleotide (CNMP) Binding Domain Containing 11 2     

External Ids:    HGNC: 161451   Entrez Gene: 1408942   Ensembl: ENSG000001496467   UniProtKB: Q96M203   

Export aliases for CNBD2 gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for CNBD2 Gene: 
CNBD2 (cyclic nucleotide binding domain containing 2) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000020.10  NT_011362.10  NC_018931.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for CNBD2
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCNBD2 promoter sequence
   Search SABiosciences Chromatin IP Primers for CNBD2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CNBD2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q11.23   Ensembl cytogenetic band:  20q11.23   HGNC cytogenetic band: 20q11.23

CNBD2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CNBD2 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P034557:  view genomic region     (about GC identifiers)

Start:
34,556,512 bp from pter      End:
34,618,622 bp from pter
Size:
62,111 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CNBD2_HUMAN, Q96M20 (See protein sequence)
Recommended Name: Cyclic nucleotide-binding domain-containing protein 2  
Size: 576 amino acids; 67512 Da
Secondary accessions: Q14C79 Q5JWY7 Q5T3S1 Q9BR36 Q9BWY5
Alternative splicing: 3 isoforms:  Q96M20-1   Q96M20-2   Q96M20-3   

Explore the universe of human proteins at neXtProt for CNBD2: NX_Q96M20

Explore proteomics data for CNBD2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96M20

  • CNBD2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CNBD2 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001194005.1  NP_543024.2  

    ENSEMBL proteins: 
     ENSP00000363084   ENSP00000340954   ENSP00000476014   ENSP00000442729  

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    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR018488 cNMP-bd_CS
     IPR018490 cNMP-bd-like
     IPR000595 cNMP-bd_dom
     IPR014710 RmlC-like_jellyroll

    Graphical View of Domain Structure for InterPro Entry Q96M20

    ProtoNet protein and cluster: Q96M20

    1 Blocks protein domain: IPB000595 Cyclic nucleotide-binding domain

    UniProtKB/Swiss-Prot: CNBD2_HUMAN, Q96M20
    Similarity: Contains 1 cyclic nucleotide-binding domain


    CNBD2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for CNBD2 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CNBD2 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CNBD2

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CNBD2

    Search CenterWatch for drugs/clinical trials and news about CNBD2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CNBD2 gene (2 alternative transcripts): 
    NM_001207076.1  NM_080834.2  

    Unigene Cluster for CNBD2:

    Cyclic nucleotide binding domain containing 2
    Hs.732697  [show with all ESTs]
    Unigene Representative Sequence: BC030782
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000373973 ENST00000349339(uc002xer.1 uc002xes.1 uc010gfp.1)
    ENST00000489667 ENST00000463258 ENST00000538900
    miRNA
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    Additional mRNA sequence: 

    AK057454.1 BC030782.1 BC057288.1 BC114945.1 

    8 DOTS entries:

    DT.95355004  DT.91850591  DT.99998372  DT.75123214  DT.120832145  DT.454410  DT.99959541  DT.99959545 

    21 AceView cDNA sequences:

    AA905322 BC057288 BX101299 AL844384 AK057454 AL844336 AI191598 AI765510 
    AL844348 BI825283 BC030782 AW340269 NM_080834 BG720749 CD635973 BF439347 
    BX420805 BG461373 AL844446 AL844337 AL844341 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CNBD2 expression in normal human tissues (normalized intensities)      CNBD2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CNBD2 Expression
    About this image


    CNBD2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/4 selected tissues (see all 4) fully expand
     
     Testis (Reproductive System)
             sperm   
     
     Blood Brain Barrier (Nervous System)
             Endothelial Cells Blood Brain Barrier
     
     Endothelium (Cardiovascular System)
             Endothelial Cells Blood Brain Barrier
     
     Brain (Nervous System)
             Endothelial Cells Blood Brain Barrier

    See CNBD2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CNBD2

    SOURCE GeneReport for Unigene cluster: Hs.732697
        SABiosciences Custom PCR Arrays for CNBD2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CNBD2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CNBD2 gene from 2/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cnbd21 , 5 RIKEN cDNA 4921517L17 gene5
    cyclic nucleotide binding domain containing 21
    75.78(n)1
    66.19(a)1
      2 (77.39 cM)5
    708731  NM_027585.21  NP_081861.21 
     1563122995 
    lizard
    (Anolis carolinensis)
    Reptilia C20ORF1526
    Uncharacterized protein
    48(a)
    1 ↔ 1
    GL343208.1(3466419-3555782)


    ENSEMBL Gene Tree for CNBD2 (if available)
    TreeFam Gene Tree for CNBD2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1251 SNPs in CNBD2 are shown (see all 1251)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1859790121,2
    --34554529(+) ATTCAA/GTATTT 2 -- us2k10--------
    rs1385269751,2
    C--34554559(+) GTCTTA/CTGTTT 2 -- us2k10--------
    rs1132443501,2
    C--34554572(+) CTGAGT/-TTTTT 2 -- us2k11Minor allele frequency- -:0.50CSA 2
    rs1427784571,2
    C--34554604(+) GACTT-/AATGGG 2 -- us2k10--------
    rs1895920451,2
    --34554611(+) TGGGAC/TAGTAC 2 -- us2k10--------
    rs1403046781,2
    C--34554628(+) CCCACA/GTTCCA 2 -- us2k10--------
    rs60607251,2
    H--34554675(+) GCTAAG/AGTGCT 2 -- us2k14Minor allele frequency- A:0.00NS EA 418
    rs1811336331,2
    --34554799(+) GTGTTG/TTTCTT 2 -- us2k10--------
    rs1869530331,2
    --34554816(+) CCCACG/TTCCTA 2 -- us2k10--------
    rs1434906981,2
    --34554977(+) AAAGTA/GTGCCT 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for CNBD2 (34556512 - 34618622 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for CNBD2: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CNBD2
    DNA2.0 Custom Variant and Variant Library Synthesis for CNBD2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CNBD2 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with CNBD2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2, 3 Deloukas P....Rogers J. (2001)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 140894 HGNC: 16145 AceView: C20orf152 Ensembl:ENSG00000149646 euGenes: HUgn140894
    ECgene: CNBD2 H-InvDB: CNBD2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CNBD2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CNBD2 gene:
    Search GeneIP for patents involving CNBD2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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     Search for Antibodies for CNBD2 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for CNBD2
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     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Browse Proteins at Cloud-Clone Corp.
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     Browse ELISAs at Cloud-Clone Corp.
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     Search LifeMap BioReagents cell lines for CNBD2
     Gene Synthesis
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     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CNBD2
     Browse SwitchGear 3'UTR luciferase reporter plasmids for CNBD2
     SwitchGear Promoter luciferase reporter plasmids for CNBD2
     Search ThermoFisher Antibodies for CNBD2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CNBD2
     inGenious Targeting Laboratory - Custom generated mouse model solutions for CNBD2
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CNBD2
    Customized:
     lentivirus for stable overexpression of CNBD2
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     Search LSBio for Antibodies for CNBD2
    Customized transgenic rodents for:
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
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