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Aliases for CMTR2 Gene

Aliases for CMTR2 Gene

  • Cap Methyltransferase 2 2 3 4 5
  • FtsJ Methyltransferase Domain-Containing Protein 1 3 4
  • FtsJ Methyltransferase Domain Containing 1 2 3
  • Cap2 2O-Ribose Methyltransferase 2 3 4
  • Protein Adrift Homolog 3 4
  • FTSJD1 3 4
  • HMTr2 3 4
  • MTr2 3 4
  • AFT 3 4
  • Cap-Specific MRNA (Nucleoside-2-O-)-Methyltransferase 2 3
  • Adrift Homolog (Drosophila) 2
  • Adrift Homolog 3
  • EC 2.1.1.296 4

External Ids for CMTR2 Gene

Previous HGNC Symbols for CMTR2 Gene

  • FTSJD1

Summaries for CMTR2 Gene

GeneCards Summary for CMTR2 Gene

CMTR2 (Cap Methyltransferase 2) is a Protein Coding gene. Among its related pathways are Pathways Affected in Adenoid Cystic Carcinoma. GO annotations related to this gene include methyltransferase activity and mRNA (nucleoside-2-O-)-methyltransferase activity. An important paralog of this gene is CMTR1.

UniProtKB/Swiss-Prot for CMTR2 Gene

  • S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap2 2-O-ribose methylation to the 5-cap structure of mRNAs. Methylates the ribose of the second nucleotide of a m(7)GpppG-capped mRNA and small nuclear RNA (snRNA) (cap0) to produce m(7)GpppRmpNm (cap2). Recognizes a guanosine cap on RNA independently of its N(7) methylation status. Display cap2 methylation on both cap0 and cap1. Displays a preference for cap1 RNAs.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CMTR2 Gene

Genomics for CMTR2 Gene

Regulatory Elements for CMTR2 Gene

Enhancers for CMTR2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16G071254 1.4 Ensembl ENCODE 8.1 +34.0 34019 1.7 HDGF PKNOX1 CREB3L1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SF3B3 DHX38 AP1G1 CMTR2 HYDIN LOC102723786
GH16G071287 1.1 ENCODE 10.3 +0.6 593 2.5 HDGF PKNOX1 FOXA2 MLX CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 SF3B3 AP1G1 DHX38 ATXN1L CMTR2 LOC102723786
GH16G070680 2 FANTOM5 Ensembl ENCODE dbSUPER 4.3 +595.0 595013 29.2 CREB3L1 MLX ZFP64 DMAP1 YY1 ZNF143 SP3 NFYC TBX21 MEF2D VAC14-AS1 MTSS1L CLEC18A NPIPB14P NOB1 VAC14 EXOSC6 NQO1 SMG1P7 MARVELD3
GH16G072008 1.1 ENCODE 6.8 -719.1 -719092 1.5 HDGF PKNOX1 MLX ZFP64 ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF302 DHODH DHX38 HPR CMTR2 PIR31360
GH16G071027 0.9 ENCODE dbSUPER 6.9 +261.4 261449 2.2 TEAD4 CEBPB CHD1 RBBP5 CHD7 EP300 ZBTB40 ATF2 ETS1 HDAC2 CMTR2 ENSG00000259833 RNU6ATAC25P
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CMTR2 on UCSC Golden Path with GeneCards custom track

Promoters for CMTR2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000087635 415 1801 HDGF PKNOX1 FOXA2 MLX CREB3L1 ZFP64 ARID4B SIN3A FEZF1 DMAP1

Genomic Location for CMTR2 Gene

Chromosome:
16
Start:
71,281,389 bp from pter
End:
71,289,715 bp from pter
Size:
8,327 bases
Orientation:
Minus strand

Genomic View for CMTR2 Gene

Genes around CMTR2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CMTR2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CMTR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CMTR2 Gene

Proteins for CMTR2 Gene

  • Protein details for CMTR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IYT2-CMTR2_HUMAN
    Recommended name:
    Cap-specific mRNA (nucleoside-2-O-)-methyltransferase 2
    Protein Accession:
    Q8IYT2
    Secondary Accessions:
    • B2RCD5
    • D3DWS1
    • Q8NE77
    • Q8NFR5
    • Q9H8Z4
    • Q9NUS3
    • Q9NXF5

    Protein attributes for CMTR2 Gene

    Size:
    770 amino acids
    Molecular mass:
    88120 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAM49718.1; Type=Frameshift; Positions=337; Evidence={ECO:0000305}; Sequence=BAA91058.1; Type=Frameshift; Positions=739; Evidence={ECO:0000305}; Sequence=BAB14452.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for CMTR2 Gene

Post-translational modifications for CMTR2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CMTR2 Gene

Domains & Families for CMTR2 Gene

Suggested Antigen Peptide Sequences for CMTR2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CMTR2: view

No data available for UniProtKB/Swiss-Prot for CMTR2 Gene

Function for CMTR2 Gene

Molecular function for CMTR2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
S-adenosyl-L-methionine + a 5-(N(7)-methyl 5-triphosphoguanosine)-(2-O-methyl-purine-ribonucleotide)-(ribonucleotide)-[mRNA] = S-adenosyl-L-homocysteine + a 5-(N(7)-methyl 5-triphosphoguanosine)-(2-O-methyl-purine-ribonucleotide)-(2-O-methyl-ribonucleotide)-[mRNA].
UniProtKB/Swiss-Prot Function:
S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap2 2-O-ribose methylation to the 5-cap structure of mRNAs. Methylates the ribose of the second nucleotide of a m(7)GpppG-capped mRNA and small nuclear RNA (snRNA) (cap0) to produce m(7)GpppRmpNm (cap2). Recognizes a guanosine cap on RNA independently of its N(7) methylation status. Display cap2 methylation on both cap0 and cap1. Displays a preference for cap1 RNAs.

Enzyme Numbers (IUBMB) for CMTR2 Gene

Gene Ontology (GO) - Molecular Function for CMTR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004483 mRNA (nucleoside-2-O-)-methyltransferase activity IDA 21310715
GO:0008168 methyltransferase activity IEA --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with CMTR2: view
genes like me logo Genes that share phenotypes with CMTR2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CMTR2 Gene

Localization for CMTR2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CMTR2 Gene

Nucleus. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CMTR2 gene
Compartment Confidence
nucleus 5
cytosol 2
plasma membrane 1
extracellular 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CMTR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 21310715
GO:0005737 cytoplasm IDA,IEA 21310715
genes like me logo Genes that share ontologies with CMTR2: view

Pathways & Interactions for CMTR2 Gene

genes like me logo Genes that share pathways with CMTR2: view

Pathways by source for CMTR2 Gene

1 BioSystems pathway for CMTR2 Gene

Interacting Proteins for CMTR2 Gene

Gene Ontology (GO) - Biological Process for CMTR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006370 7-methylguanosine mRNA capping IDA,IEA 21310715
GO:0006397 mRNA processing IEA --
GO:0032259 methylation IEA --
GO:0097310 cap2 mRNA methylation IDA 21310715
genes like me logo Genes that share ontologies with CMTR2: view

No data available for SIGNOR curated interactions for CMTR2 Gene

Drugs & Compounds for CMTR2 Gene

No Compound Related Data Available

Transcripts for CMTR2 Gene

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CMTR2 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d · 5e · 5f · 5g
SP1: - - - - -
SP2: - - - -
SP3: - - -
SP4: -
SP5: - - - -
SP6: - - - - -
SP7:
SP8: - -
SP9:

Relevant External Links for CMTR2 Gene

GeneLoc Exon Structure for
CMTR2
ECgene alternative splicing isoforms for
CMTR2

Expression for CMTR2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CMTR2 Gene

Protein differential expression in normal tissues from HIPED for CMTR2 Gene

This gene is overexpressed in Tlymphocyte (39.5), Lymph node (12.3), and Testis (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CMTR2 Gene



NURSA nuclear receptor signaling pathways regulating expression of CMTR2 Gene:

CMTR2

Evidence on tissue expression from TISSUES for CMTR2 Gene

  • Nervous system(2.4)
genes like me logo Genes that share expression patterns with CMTR2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CMTR2 Gene

Orthologs for CMTR2 Gene

This gene was present in the common ancestor of animals.

Orthologs for CMTR2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FTSJD1 34
  • 98.92 (n)
dog
(Canis familiaris)
Mammalia CMTR2 34 35
  • 90.21 (n)
cow
(Bos Taurus)
Mammalia CMTR2 34 35
  • 88.66 (n)
rat
(Rattus norvegicus)
Mammalia Cmtr2 34
  • 80.05 (n)
mouse
(Mus musculus)
Mammalia Cmtr2 34 16 35
  • 79.62 (n)
oppossum
(Monodelphis domestica)
Mammalia CMTR2 35
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CMTR2 35
  • 40 (a)
OneToOne
chicken
(Gallus gallus)
Aves FTSJD1 34
  • 71.32 (n)
CMTR2 35
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CMTR2 35
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ftsjd1 34
  • 58.92 (n)
zebrafish
(Danio rerio)
Actinopterygii cmtr2 34 35
  • 52.69 (n)
Dr.11574 34
fruit fly
(Drosophila melanogaster)
Insecta aft 35
  • 28 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea Y40D12A.1 35
  • 20 (a)
OneToOne
Species where no ortholog for CMTR2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CMTR2 Gene

ENSEMBL:
Gene Tree for CMTR2 (if available)
TreeFam:
Gene Tree for CMTR2 (if available)

Paralogs for CMTR2 Gene

Paralogs for CMTR2 Gene

genes like me logo Genes that share paralogs with CMTR2: view

Variants for CMTR2 Gene

Sequence variations from dbSNP and Humsavar for CMTR2 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1000633521 -- 71,282,206(+) AACAT(-/TAAC)TATCA downstream-variant-500B
rs1001058701 -- 71,281,882(+) AAATA(A/G)GCTGC downstream-variant-500B
rs1001198519 -- 71,287,814(+) ACATT(A/C)ACTAA intron-variant, upstream-variant-2KB
rs1001495842 -- 71,288,443(+) AAGCT(C/T)CACAG intron-variant, upstream-variant-2KB
rs1001692041 -- 71,287,564(+) AAGGA(A/G)TTGGG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CMTR2 Gene

Variant ID Type Subtype PubMed ID
esv2758653 CNV gain 17122850
esv988018 OTHER inversion 20482838
nsv1861 CNV insertion 18451855
nsv509631 CNV insertion 20534489
nsv511050 OTHER complex 20534489
nsv7285 OTHER inversion 18451855

Variation tolerance for CMTR2 Gene

Residual Variation Intolerance Score: 59.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.36; 81.63% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CMTR2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CMTR2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CMTR2 Gene

Disorders for CMTR2 Gene

Relevant External Links for CMTR2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CMTR2

No disorders were found for CMTR2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CMTR2 Gene

Publications for CMTR2 Gene

  1. 2'-O-ribose methylation of cap2 in human: function and evolution in a horizontally mobile family. (PMID: 21310715) Werner M. … Bujnicki J.M. (Nucleic Acids Res. 2011) 2 3 4 64
  2. Structural analysis of human 2'-O-ribose methyltransferases involved in mRNA cap structure formation. (PMID: 24402442) Smietanski M. … Bujnicki J.M. (Nat Commun 2014) 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3 64
  5. Gene essentiality and synthetic lethality in haploid human cells. (PMID: 26472760) Blomen V.A. … Brummelkamp T.R. (Science 2015) 3 64

Products for CMTR2 Gene

Sources for CMTR2 Gene

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