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Aliases for CMTR2 Gene

Aliases for CMTR2 Gene

  • Cap Methyltransferase 2 2 3 4 5
  • FtsJ Methyltransferase Domain-Containing Protein 1 3 4
  • FtsJ Methyltransferase Domain Containing 1 2 3
  • Cap2 2O-Ribose Methyltransferase 2 3 4
  • Protein Adrift Homolog 3 4
  • FTSJD1 3 4
  • HMTr2 3 4
  • MTr2 3 4
  • AFT 3 4
  • Adrift Homolog (Drosophila) 2
  • Adrift Homolog 3
  • EC 2.1.1.296 4

External Ids for CMTR2 Gene

Previous HGNC Symbols for CMTR2 Gene

  • FTSJD1

Summaries for CMTR2 Gene

GeneCards Summary for CMTR2 Gene

CMTR2 (Cap Methyltransferase 2) is a Protein Coding gene. GO annotations related to this gene include methyltransferase activity and mRNA (nucleoside-2-O-)-methyltransferase activity. An important paralog of this gene is CMTR1.

UniProtKB/Swiss-Prot for CMTR2 Gene

  • S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap2 2-O-ribose methylation to the 5-cap structure of mRNAs. Methylates the ribose of the second nucleotide of a m(7)GpppG-capped mRNA and small nuclear RNA (snRNA) (cap0) to produce m(7)GpppRmpNm (cap2). Recognizes a guanosine cap on RNA independently of its N(7) methylation status. Display cap2 methylation on both cap0 and cap1. Displays a preference for cap1 RNAs.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CMTR2 Gene

Genomics for CMTR2 Gene

Regulatory Elements for CMTR2 Gene

Promoters for CMTR2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CMTR2 on UCSC Golden Path with GeneCards custom track

Genomic Location for CMTR2 Gene

Chromosome:
16
Start:
71,281,389 bp from pter
End:
71,289,715 bp from pter
Size:
8,327 bases
Orientation:
Minus strand

Genomic View for CMTR2 Gene

Genes around CMTR2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CMTR2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CMTR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CMTR2 Gene

Proteins for CMTR2 Gene

  • Protein details for CMTR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IYT2-CMTR2_HUMAN
    Recommended name:
    Cap-specific mRNA (nucleoside-2-O-)-methyltransferase 2
    Protein Accession:
    Q8IYT2
    Secondary Accessions:
    • B2RCD5
    • D3DWS1
    • Q8NE77
    • Q8NFR5
    • Q9H8Z4
    • Q9NUS3
    • Q9NXF5

    Protein attributes for CMTR2 Gene

    Size:
    770 amino acids
    Molecular mass:
    88120 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAM49718.1; Type=Frameshift; Positions=337; Evidence={ECO:0000305}; Sequence=BAA91058.1; Type=Frameshift; Positions=739; Evidence={ECO:0000305}; Sequence=BAB14452.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for CMTR2 Gene

Proteomics data for CMTR2 Gene at MOPED

Post-translational modifications for CMTR2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CMTR2 Gene

Domains & Families for CMTR2 Gene

Protein Domains for CMTR2 Gene

Suggested Antigen Peptide Sequences for CMTR2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IYT2

UniProtKB/Swiss-Prot:

CMTR2_HUMAN :
  • Contains 1 Adrift-type SAM-dependent 2-O-MTase domain.
Domain:
  • Contains 1 Adrift-type SAM-dependent 2-O-MTase domain.
genes like me logo Genes that share domains with CMTR2: view

No data available for Gene Families for CMTR2 Gene

Function for CMTR2 Gene

Molecular function for CMTR2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
S-adenosyl-L-methionine + a 5-(N(7)-methyl 5-triphosphoguanosine)-(2-O-methyl-purine-ribonucleotide)-(ribonucleotide)-[mRNA] = S-adenosyl-L-homocysteine + a 5-(N(7)-methyl 5-triphosphoguanosine)-(2-O-methyl-purine-ribonucleotide)-(2-O-methyl-ribonucleotide)-[mRNA].
UniProtKB/Swiss-Prot Function:
S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap2 2-O-ribose methylation to the 5-cap structure of mRNAs. Methylates the ribose of the second nucleotide of a m(7)GpppG-capped mRNA and small nuclear RNA (snRNA) (cap0) to produce m(7)GpppRmpNm (cap2). Recognizes a guanosine cap on RNA independently of its N(7) methylation status. Display cap2 methylation on both cap0 and cap1. Displays a preference for cap1 RNAs.

Enzyme Numbers (IUBMB) for CMTR2 Gene

Gene Ontology (GO) - Molecular Function for CMTR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004483 mRNA (nucleoside-2-O-)-methyltransferase activity IDA 21310715
genes like me logo Genes that share ontologies with CMTR2: view

Phenotypes for CMTR2 Gene

genes like me logo Genes that share phenotypes with CMTR2: view

Animal Model Products

CRISPR Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CMTR2 Gene

Localization for CMTR2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CMTR2 Gene

Nucleus. Cytoplasm. Membrane; Single-pass membrane protein.

No data available for Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for CMTR2 Gene

Pathways & Interactions for CMTR2 Gene

SuperPathways for CMTR2 Gene

No Data Available

Interacting Proteins for CMTR2 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000337512%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000337512 for CMTR2 Gene via STRING

Symbol External ID(s) Details
UBC

Gene Ontology (GO) - Biological Process for CMTR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0097310 cap2 mRNA methylation IDA 21310715
genes like me logo Genes that share ontologies with CMTR2: view

No data available for Pathways by source and SIGNOR curated interactions for CMTR2 Gene

Drugs & Compounds for CMTR2 Gene

No Compound Related Data Available

Transcripts for CMTR2 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for CMTR2 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d · 5e · 5f · 5g
SP1: - - - - -
SP2: - - - -
SP3: - - -
SP4: -
SP5: - - - -
SP6: - - - - -
SP7:
SP8: - -
SP9:

Relevant External Links for CMTR2 Gene

GeneLoc Exon Structure for
CMTR2
ECgene alternative splicing isoforms for
CMTR2

Expression for CMTR2 Gene

mRNA expression in normal human tissues for CMTR2 Gene

Protein differential expression in normal tissues from HIPED for CMTR2 Gene

This gene is overexpressed in Tlymphocyte (39.5), Lymph node (12.3), and Testis (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for CMTR2 Gene



genes like me logo Genes that share expression patterns with CMTR2: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for CMTR2 Gene

Orthologs for CMTR2 Gene

This gene was present in the common ancestor of animals.

Orthologs for CMTR2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CMTR2 35
  • 88.66 (n)
  • 86.91 (a)
CMTR2 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CMTR2 35
  • 90.21 (n)
  • 90.08 (a)
CMTR2 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cmtr2 35
  • 79.62 (n)
  • 79.4 (a)
Cmtr2 16
Cmtr2 36
  • 79 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FTSJD1 35
  • 98.92 (n)
  • 98.7 (a)
rat
(Rattus norvegicus)
Mammalia Cmtr2 35
  • 80.05 (n)
  • 80.44 (a)
oppossum
(Monodelphis domestica)
Mammalia CMTR2 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CMTR2 36
  • 40 (a)
OneToOne
chicken
(Gallus gallus)
Aves FTSJD1 35
  • 71.32 (n)
  • 67.85 (a)
CMTR2 36
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CMTR2 36
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ftsjd1 35
  • 58.92 (n)
  • 54.52 (a)
zebrafish
(Danio rerio)
Actinopterygii cmtr2 35
  • 52.69 (n)
  • 45.86 (a)
Dr.11574 35
cmtr2 36
  • 44 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta aft 36
  • 28 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea Y40D12A.1 36
  • 20 (a)
OneToOne
Species with no ortholog for CMTR2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CMTR2 Gene

ENSEMBL:
Gene Tree for CMTR2 (if available)
TreeFam:
Gene Tree for CMTR2 (if available)

Paralogs for CMTR2 Gene

Paralogs for CMTR2 Gene

genes like me logo Genes that share paralogs with CMTR2: view

Variants for CMTR2 Gene

Sequence variations from dbSNP and Humsavar for CMTR2 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs3096380 - 71,285,743(-) CTGAA(C/T)TTAAT reference, missense
rs17853360 - 71,285,433(+) AAGGA(A/T)ACCGA reference, missense
rs3803704 - 71,284,674(-) CAGAA(A/G)TAATT reference, missense
rs3096381 - 71,284,098(-) ACTCA(A/C/T)AACTT reference, missense
rs16970857 - 71,283,664(+) AATGA(A/G)ATGCA reference, missense

Variation tolerance for CMTR2 Gene

Residual Variation Intolerance Score: 59.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.36; 81.63% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CMTR2 Gene

HapMap Linkage Disequilibrium report
CMTR2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CMTR2 Gene

Disorders for CMTR2 Gene

Relevant External Links for CMTR2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CMTR2

No disorders were found for CMTR2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CMTR2 Gene

Publications for CMTR2 Gene

  1. 2'-O-ribose methylation of cap2 in human: function and evolution in a horizontally mobile family. (PMID: 21310715) Werner M. … Bujnicki J.M. (Nucleic Acids Res. 2011) 2 3 4 67
  2. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for CMTR2 Gene

Sources for CMTR2 Gene

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