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CMTR2 Gene

protein-coding   GIFtS: 34
GCID: GC16M071315

Cap Methyltransferase 2

(Previous name: FtsJ methyltransferase domain containing 1)
(Previous symbol: FTSJD1)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cap Methyltransferase 21 2 3     HMTr22 3
FTSJD11 2 3     MTr22 3
FtsJ Methyltransferase Domain Containing 11 2     Adrift Homolog (Drosophila)1
Cap2 2'O-Ribose Methyltransferase 22 3     Adrift Homolog2
FtsJ Methyltransferase Domain-Containing Protein 12 3     Cap-Specific MRNA (Nucleoside-2'-O-)-Methyltransferase 22
Protein Adrift Homolog2 3     EC 2.1.1.-3
AFT2 3     

External Ids:    HGNC: 256351   Entrez Gene: 557832   Ensembl: ENSG000001809177   UniProtKB: Q8IYT23   

Export aliases for CMTR2 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CMTR2 Gene:
CMTR2 (cap methyltransferase 2) is a protein-coding gene. GO annotations related to this gene include mRNA (nucleoside-2'-O-)-methyltransferase activity. An important paralog of this gene is CMTR1.

UniProtKB/Swiss-Prot: CMTR2_HUMAN, Q8IYT2
Function: S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap2 2'-O-ribose methylation to
the 5'-cap structure of mRNAs. Methylates the ribose of the second nucleotide of a m(7)GpppG-capped mRNA and
small nuclear RNA (snRNA) (cap0) to produce m(7)GpppRmpNm (cap2). Recognizes a guanosine cap on RNA independently
of its N(7) methylation status. Display cap2 methylation on both cap0 and cap1. Displays a preference for cap1
RNAs




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Search for regulatory transcription factor binding sites for CMTR2
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCMTR2 promoter sequence
   Search Chromatin IP Primers for CMTR2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CMTR2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q22.2   Ensembl cytogenetic band:  16q22.2   HGNC cytogenetic band: 16q22.2

CMTR2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CMTR2 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M071315:  view genomic region     (about GC identifiers)

Start:
71,315,292 bp from pter      End:
71,323,618 bp from pter
Size:
8,327 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CMTR2_HUMAN, Q8IYT2 (See protein sequence)
Recommended Name: Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2  
Size: 770 amino acids; 88120 Da
Sequence caution: Sequence=AAM49718.1; Type=Frameshift; Positions=337; Sequence=BAA91058.1; Type=Frameshift;
Positions=739; Sequence=BAB14452.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: B2RCD5 D3DWS1 Q8NE77 Q8NFR5 Q9H8Z4 Q9NUS3 Q9NXF5

Explore the universe of human proteins at neXtProt for CMTR2: NX_Q8IYT2

Explore proteomics data for CMTR2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CMTR2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001093112.1  NP_060818.4  

    ENSEMBL proteins: 
     ENSP00000337512   ENSP00000411148   ENSP00000457399   ENSP00000456036   ENSP00000456476  
     ENSP00000455080   ENSP00000457679  

    CMTR2 Human Recombinant Protein Products:

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    OriGene Custom MassSpec
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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for CMTR2 

    CMTR2 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Novus Biologicals CMTR2 Antibodies
    Search for Antibodies for CMTR2 at Abcam
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    LSBio Antibodies in human, mouse, rat for CMTR2

    CMTR2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for CMTR2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR025807 Adrift_MeTrfase
     IPR002877 rRNA_MeTrfase_FtsJ_dom

    Graphical View of Domain Structure for InterPro Entry Q8IYT2

    ProtoNet protein and cluster: Q8IYT2

    1 Blocks protein domain: IPB002877 Cell division protein FtsJ

    UniProtKB/Swiss-Prot: CMTR2_HUMAN, Q8IYT2
    Similarity: Contains 1 Adrift-type SAM-dependent 2'-O-MTase domain


    Find genes that share domains with CMTR2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CMTR2_HUMAN, Q8IYT2
    Function: S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap2 2'-O-ribose methylation to
    the 5'-cap structure of mRNAs. Methylates the ribose of the second nucleotide of a m(7)GpppG-capped mRNA and
    small nuclear RNA (snRNA) (cap0) to produce m(7)GpppRmpNm (cap2). Recognizes a guanosine cap on RNA independently
    of its N(7) methylation status. Display cap2 methylation on both cap0 and cap1. Displays a preference for cap1
    RNAs
    Catalytic activity: S-adenosyl-L-methionine + m(7)G(5')pppRmpN-RNA = S-adenosyl-L-homocysteine +
    m(7)G(5')pppRmpNm-RNA

         Enzyme Number (IUBMB): EC 2.1.1.-1

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004483mRNA (nucleoside-2'-O-)-methyltransferase activity IDA--
    GO:0008168methyltransferase activity ----
         
    Find genes that share ontologies with CMTR2           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CMTR2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CMTR2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CMTR2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CMTR2

    miRNA
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    miRTarBase miRNAs that target CMTR2:
    hsa-mir-378a-5p (MIRT044007)

    Block miRNA regulation of human, mouse, rat CMTR2 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate CMTR2
    SwitchGear 3'UTR luciferase reporter plasmidCMTR2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CMTR2

    Gene Editing
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    Clone
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    GenScript Custom all cDNA clones Services for CMTR2
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CMTR2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CMTR2

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for CMTR2 
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CMTR2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CMTR2_HUMAN, Q8IYT2: Nucleus. Cytoplasm. Membrane; Single-pass membrane protein (Potential)

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005737cytoplasm IDA--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with CMTR2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CMTR2
    Interactions:

        Search GeneGlobe Interaction Network for CMTR2

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for CMTR2 (ENSP000003375124) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:00063707-methylguanosine mRNA capping IDA--
    GO:0032259methylation ----
    GO:0097310cap2 mRNA methylation IDA--

    Find genes that share ontologies with CMTR2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CMTR2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CMTR2 gene (2 alternative transcripts): 
    NM_001099642.1  NM_018348.5  

    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000338099(uc002ezz.4) ENST00000434935(uc010cga.3 uc002ezy.4)
    ENST00000563876 ENST00000564183 ENST00000565850 ENST00000567610 ENST00000568910
    ENST00000564690
    miRNA
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    Block miRNA regulation of human, mouse, rat CMTR2 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate CMTR2
    SwitchGear 3'UTR luciferase reporter plasmidCMTR2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CMTR2
    Predesigned siRNA for gene silencing in human, mouse, rat CMTR2
    Clone
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    OriGene ORF clones in mouse, rat for CMTR2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for CMTR2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CMTR2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CMTR2
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for CMTR2
    Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat CMTR2
      QuantiTect SYBR Green Assays in human, mouse, rat CMTR2
      QuantiFast Probe-based Assays in human, mouse, rat CMTR2

    Selected AceView cDNA sequences (see all 98):

    BC034468 BQ942396 BM724515 NM_018348 BQ632350 AA282527 BQ575586 AA630387 
    AA282635 BQ632644 BC035005 BM461820 BM745619 AU119050 BF434869 AA196702 
    AA044588 AW079291 BG720202 AW137210 AI185702 BP337326 BM819164 BU569926 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CMTR2 (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d · 5e · 5f · 5g
    SP1:                                -     -           -     -     -                                             
    SP2:                                      -           -     -     -                                             
    SP3:                                                  -     -     -                                             
    SP4:                                      -                                                                     
    SP5:                                            -     -     -     -                                             


    ECgene alternative splicing isoforms for CMTR2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CMTR2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CMTR2 Expression
    About this image

    CMTR2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CMTR2 Protein Expression
        Custom PCR Arrays for CMTR2
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CMTR2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CMTR2 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ftsjd15
    Cmtr21
    FtsJ methyltransferase domain containing 15
    cap methyltransferase 21
    79.62(n)1
    79.4(a)1
      8 (57.48 cM)5
    2347281  NM_146215.41  NP_666327.21 
     1102179605 
    chicken
    (Gallus gallus)
    Aves FTSJD11 FtsJ methyltransferase domain containing 1 71.32(n)
    67.85(a)
      427537  XM_004944110.1  XP_004944167.1 
    lizard
    (Anolis carolinensis)
    Reptilia CMTR26
    cap methyltransferase 2
    65(a)
    1 ↔ 1
    3(196172277-196180032)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia ftsjd11 FtsJ methyltransferase domain containing 1 58.92(n)
    54.52(a)
      100496665  XM_004914328.1  XP_004914385.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.115742 Danio rerio mRNA similar to hypothetical protein FLJ11171 more 73.53(n)    BC045425.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta aft6
    adrift
    28(a)
    1 ↔ 1
    2R(13673642-13676072)
    worm
    (Caenorhabditis elegans)
    Secernentea Y40D12A.16
    Protein Y40D12A.1, isoform a
    20(a)
    1 ↔ 1
    III(6615414-6620049) WBGene00021502


    ENSEMBL Gene Tree for CMTR2 (if available)
    TreeFam Gene Tree for CMTR2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CMTR2 gene
    CMTR12  

    Find genes that share paralogs with CMTR2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CMTR2 (see all 236)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs113691951,2
    C--71315862(+) TTTTTT/-CCTCC 2 -- int11Minor allele frequency- -:0.00NA 2
    rs2004093651,2
    C--71315873(-) AGGAGA/GAAAAA 2 -- int10--------
    rs64994951,2
    C,F,H--71315908(+) CCATCA/GTCATA 2 -- int118Minor allele frequency- G:0.02NS EA NA WA CSA 1048
    rs14241451,2
    C,F--71316057(-) TAATAT/CTGTAA 2 -- int112Minor allele frequency- C:0.48NA WA CSA EA 375
    rs1386525891,2
    --71316262(+) GAACAC/TGAAAA 2 -- ut310--------
    rs1411643441,2
    --71316302(+) CATCAA/GAAAAT 2 -- ut310--------
    rs1503183751,2
    C--71316490(+) CAAATA/GTAACT 2 -- ut310--------
    rs1898410021,2
    --71316522(+) CTAATC/GTTTTG 2 -- ut310--------
    rs74996801,2
    C,H--71316596(+) ACCATC/GATTCT 2 -- ut31 ese34Minor allele frequency- G:0.00NS EA 420
    rs1816088691,2
    --71316642(+) TTCATC/TACATT 2 -- ut310--------

    HapMap Linkage Disequilibrium report for CMTR2 (71315292 - 71323618 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for CMTR2: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CMTR2
    DNA2.0 Custom Variant and Variant Library Synthesis for CMTR2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CMTR2 gene, integrated from 10 sources (see all 11):
    (articles sorted by number of sources associating them with CMTR2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. 2'-O-ribose methylation of cap2 in human: function and evolution in a horizontally mobile family. (PubMed id 21310715)1, 2, 3 Werner M....Bujnicki J.M. (Nucleic Acids Res. 2011)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    4. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    5. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    6. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    7. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    8. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    9. The sequence and analysis of duplication-rich human chromosome 16. (PubMed id 15616553)2 Martin J.... Pennacchio L.A. (Nature 2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55783 HGNC: 25635 AceView: FLJ11171 Ensembl:ENSG00000180917 euGenes: HUgn55783
    ECgene: CMTR2 H-InvDB: CMTR2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CMTR2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CMTR2 gene:
    Search GeneIP for patents involving CMTR2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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