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Aliases for CMTR1 Gene

Aliases for CMTR1 Gene

  • Cap Methyltransferase 1 2 3 4 5
  • KIAA0082 2 3 4
  • FtsJ Methyltransferase Domain-Containing Protein 2 3 4
  • FtsJ Methyltransferase Domain Containing 2 2 3
  • Interferon-Stimulated Gene 95 KDa Protein 3 4
  • Cap1 2O-Ribose Methyltransferase 1 3 4
  • FTSJD2 3 4
  • ISG95 3 4
  • HMTr1 3 4
  • MTr1 3 4
  • S-Adenosyl-L-Methionine-Dependent Methyltransferase FTSJD2 3
  • EC 2.1.1.57 4

External Ids for CMTR1 Gene

Previous HGNC Symbols for CMTR1 Gene

  • KIAA0082
  • FTSJD2

Previous GeneCards Identifiers for CMTR1 Gene

  • GC06P037401
  • GC06P037506
  • GC06P037465
  • GC06P037864

Summaries for CMTR1 Gene

GeneCards Summary for CMTR1 Gene

CMTR1 (Cap Methyltransferase 1) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and mRNA (nucleoside-2-O-)-methyltransferase activity. An important paralog of this gene is CMTR2.

UniProtKB/Swiss-Prot for CMTR1 Gene

  • S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap1 2-O-ribose methylation to the 5-cap structure of mRNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA and small nuclear RNA (snRNA) to produce m(7)GpppRm (cap1). Displays a preference for cap0 transcripts. Cap1 modification is linked to higher levels of translation. May be involved in the interferon response pathway.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CMTR1 Gene

Genomics for CMTR1 Gene

Regulatory Elements for CMTR1 Gene

Promoters for CMTR1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CMTR1 on UCSC Golden Path with GeneCards custom track

Genomic Location for CMTR1 Gene

Chromosome:
6
Start:
37,433,131 bp from pter
End:
37,482,827 bp from pter
Size:
49,697 bases
Orientation:
Plus strand

Genomic View for CMTR1 Gene

Genes around CMTR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CMTR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CMTR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CMTR1 Gene

Proteins for CMTR1 Gene

  • Protein details for CMTR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N1G2-CMTR1_HUMAN
    Recommended name:
    Cap-specific mRNA (nucleoside-2-O-)-methyltransferase 1
    Protein Accession:
    Q8N1G2
    Secondary Accessions:
    • A8K949
    • Q14670
    • Q96FJ9

    Protein attributes for CMTR1 Gene

    Size:
    835 amino acids
    Molecular mass:
    95321 Da
    Quaternary structure:
    • Interacts with POLR2A (via C-terminus).
    SequenceCaution:
    • Sequence=BAA07893.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CMTR1 Gene

neXtProt entry for CMTR1 Gene

Proteomics data for CMTR1 Gene at MOPED

Post-translational modifications for CMTR1 Gene

  • Ubiquitination at Lys 487, Lys 608, Lys 777, and Lys 823
  • Modification sites at PhosphoSitePlus

Other Protein References for CMTR1 Gene

No data available for DME Specific Peptides for CMTR1 Gene

Domains & Families for CMTR1 Gene

Gene Families for CMTR1 Gene

Graphical View of Domain Structure for InterPro Entry

Q8N1G2

UniProtKB/Swiss-Prot:

CMTR1_HUMAN :
  • Contains 1 G-patch domain.
Domain:
  • Contains 1 G-patch domain.
  • Contains 1 RrmJ-type SAM-dependent 2-O-MTase domain.
  • Contains 1 WW domain.
genes like me logo Genes that share domains with CMTR1: view

Function for CMTR1 Gene

Molecular function for CMTR1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
S-adenosyl-L-methionine + a 5-(N(7)-methyl 5-triphosphoguanosine)-(purine-ribonucleotide)-[mRNA] = S-adenosyl-L-homocysteine + a 5-(N(7)-methyl 5-triphosphoguanosine)-(2-O-methyl-purine-ribonucleotide)-[mRNA].
UniProtKB/Swiss-Prot Function:
S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap1 2-O-ribose methylation to the 5-cap structure of mRNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA and small nuclear RNA (snRNA) to produce m(7)GpppRm (cap1). Displays a preference for cap0 transcripts. Cap1 modification is linked to higher levels of translation. May be involved in the interferon response pathway.
UniProtKB/Swiss-Prot Induction:
By interferons alpha and beta, and by Vaccinia virus infection.

Enzyme Numbers (IUBMB) for CMTR1 Gene

Gene Ontology (GO) - Molecular Function for CMTR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004483 mRNA (nucleoside-2-O-)-methyltransferase activity IEA,IDA 20713356
GO:0008168 methyltransferase activity IEA --
genes like me logo Genes that share ontologies with CMTR1: view

Phenotypes for CMTR1 Gene

genes like me logo Genes that share phenotypes with CMTR1: view

Animal Model Products

CRISPR Products

miRNA for CMTR1 Gene

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CMTR1 Gene

Localization for CMTR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CMTR1 Gene

Gene Ontology (GO) - Cellular Components for CMTR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with CMTR1: view

No data available for Subcellular locations from COMPARTMENTS for CMTR1 Gene

Pathways & Interactions for CMTR1 Gene

SuperPathways for CMTR1 Gene

No Data Available

Interacting Proteins for CMTR1 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000362550%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000336741%0d%0a
Selected Interacting proteins: Q8N1G2-CMTR1_HUMAN ENSP00000362550 for CMTR1 Gene via I2D STRING

Gene Ontology (GO) - Biological Process for CMTR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006370 7-methylguanosine mRNA capping IEA,IMP 20713356
GO:0032259 methylation IEA --
genes like me logo Genes that share ontologies with CMTR1: view

No data available for Pathways by source and SIGNOR curated interactions for CMTR1 Gene

Drugs & Compounds for CMTR1 Gene

(2) Drugs for CMTR1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
S-Adenosylmethionine Approved Nutra 0
s-adenosylhomocysteine Experimental Pharma 0
genes like me logo Genes that share compounds with CMTR1: view

Transcripts for CMTR1 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for CMTR1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a · 21b ^ 22a · 22b ^
SP1: - - - - - -
SP2: - - - -
SP3: - - - - -
SP4:
SP5:
SP6:
SP7:
SP8: - -
SP9:

ExUns: 23a · 23b ^ 24a · 24b ^ 25 ^ 26a · 26b ^ 27
SP1: - -
SP2:
SP3:
SP4: - -
SP5:
SP6: - - -
SP7:
SP8:
SP9:

Relevant External Links for CMTR1 Gene

GeneLoc Exon Structure for
CMTR1
ECgene alternative splicing isoforms for
CMTR1

Expression for CMTR1 Gene

mRNA expression in normal human tissues for CMTR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CMTR1 Gene

This gene is overexpressed in Testis (20.6), Breast (13.9), and Lymph node (12.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for CMTR1 Gene



genes like me logo Genes that share expression patterns with CMTR1: view

Protein tissue co-expression partners for CMTR1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CMTR1 Gene

Orthologs for CMTR1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CMTR1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FTSJD2 36
  • 100 (a)
OneToOne
FTSJD2 35
  • 99.84 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia CMTR1 35
  • 91.26 (n)
  • 95.21 (a)
FTSJD2 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CMTR1 36
  • 97 (a)
OneToOne
FTSJD2 35
  • 92.38 (n)
  • 96.89 (a)
mouse
(Mus musculus)
Mammalia Cmtr1 36
  • 90 (a)
OneToOne
Cmtr1 16
Cmtr1 35
  • 87.3 (n)
  • 90.38 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia CMTR1 36
  • 81 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cmtr1 35
  • 86.66 (n)
  • 90.26 (a)
chicken
(Gallus gallus)
Aves FTSJD2 35
  • 76.72 (n)
  • 84.56 (a)
CMTR1 36
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CMTR1 36
  • 81 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.7896 35
zebrafish
(Danio rerio)
Actinopterygii cmtr1 36
  • 71 (a)
OneToOne
cmtr1 35
  • 67.44 (n)
  • 71.48 (a)
zgc55336 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000826 35
  • 52.41 (n)
  • 42.76 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG6379 36
  • 36 (a)
OneToOne
CG6379 35
  • 50 (n)
  • 40.41 (a)
worm
(Caenorhabditis elegans)
Secernentea CELE_Y53F4B.13 35
  • 51.75 (n)
  • 42.9 (a)
Y53F4B.13 36
  • 31 (a)
OneToOne
Species with no ortholog for CMTR1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for CMTR1 Gene

ENSEMBL:
Gene Tree for CMTR1 (if available)
TreeFam:
Gene Tree for CMTR1 (if available)

Paralogs for CMTR1 Gene

Paralogs for CMTR1 Gene

(1) SIMAP similar genes for CMTR1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with CMTR1: view

Variants for CMTR1 Gene

Sequence variations from dbSNP and Humsavar for CMTR1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs914350 -- 37,454,661(+) TAGAG(A/G)TGTTA intron-variant
rs904249 -- 37,462,712(-) TAGGC(C/T)TACGC intron-variant
rs904250 -- 37,461,709(-) GTACA(C/T)GTTCT intron-variant
rs1224127 -- 37,449,780(-) TGTTA(C/T)TCAAA intron-variant
rs1224129 -- 37,445,633(-) CAGGC(A/G)CCTGT intron-variant

Variation tolerance for CMTR1 Gene

Residual Variation Intolerance Score: 4.69% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.91; 18.86% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CMTR1 Gene

HapMap Linkage Disequilibrium report
CMTR1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CMTR1 Gene

Disorders for CMTR1 Gene

Relevant External Links for CMTR1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CMTR1

No disorders were found for CMTR1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CMTR1 Gene

Publications for CMTR1 Gene

  1. Characterization of hMTr1, a human Cap1 2'-O-Ribose methyltransferase. (PMID: 20713356) Belanger F. … Pelletier J. (J. Biol. Chem. 2010) 2 3 4 67
  2. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. 2'-O-ribose methylation of cap2 in human: function and evolution in a horizontally mobile family. (PMID: 21310715) Werner M. … Bujnicki J.M. (Nucleic Acids Res. 2011) 3

Products for CMTR1 Gene

Sources for CMTR1 Gene

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