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Aliases for CMTR1 Gene

Aliases for CMTR1 Gene

  • Cap Methyltransferase 1 2 3 4
  • KIAA0082 2 3 4
  • FtsJ Methyltransferase Domain-Containing Protein 2 3 4
  • FtsJ Methyltransferase Domain Containing 2 2 3
  • Interferon-Stimulated Gene 95 KDa Protein 3 4
  • Cap1 2O-Ribose Methyltransferase 1 3 4
  • FTSJD2 3 4
  • ISG95 3 4
  • HMTr1 3 4
  • MTR1 3 4
  • S-Adenosyl-L-Methionine-Dependent Methyltransferase FTSJD2 3
  • Cap-Specific MRNA (Nucleoside-2-O-)-Methyltransferase 1 3
  • EC 2.1.1.57 4

External Ids for CMTR1 Gene

Previous HGNC Symbols for CMTR1 Gene

  • KIAA0082
  • FTSJD2

Previous GeneCards Identifiers for CMTR1 Gene

  • GC06P037401
  • GC06P037506

Summaries for CMTR1 Gene

GeneCards Summary for CMTR1 Gene

CMTR1 (Cap Methyltransferase 1) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and mRNA (nucleoside-2-O-)-methyltransferase activity. An important paralog of this gene is CMTR2.

UniProtKB/Swiss-Prot for CMTR1 Gene

  • S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap1 2-O-ribose methylation to the 5-cap structure of mRNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA and small nuclear RNA (snRNA) to produce m(7)GpppRm (cap1). Displays a preference for cap0 transcripts. Cap1 modification is linked to higher levels of translation. May be involved in the interferon response pathway.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CMTR1 Gene

Genomics for CMTR1 Gene

Genomic Location for CMTR1 Gene

Start:
37,433,131 bp from pter
End:
37,482,827 bp from pter
Size:
49,697 bases
Orientation:
Plus strand

Genomic View for CMTR1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CMTR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CMTR1 Gene

No data available for Regulatory Elements for CMTR1 Gene

Proteins for CMTR1 Gene

  • Protein details for CMTR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N1G2-CMTR1_HUMAN
    Recommended name:
    Cap-specific mRNA (nucleoside-2-O-)-methyltransferase 1
    Protein Accession:
    Q8N1G2
    Secondary Accessions:
    • A8K949
    • Q14670
    • Q96FJ9

    Protein attributes for CMTR1 Gene

    Size:
    835 amino acids
    Molecular mass:
    95321 Da
    Quaternary structure:
    • Interacts with POLR2A (via C-terminus).
    SequenceCaution:
    • Sequence=BAA07893.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CMTR1 Gene

neXtProt entry for CMTR1 Gene

Proteomics data for CMTR1 Gene at MOPED

Post-translational modifications for CMTR1 Gene

  • Ubiquitination at Lys487, Lys608, Lys777, and Lys823
  • Modification sites at PhosphoSitePlus

Other Protein References for CMTR1 Gene

No data available for DME Specific Peptides for CMTR1 Gene

Domains for CMTR1 Gene

Gene Families for CMTR1 Gene

HGNC:
  • GPATCH :G patch domain containing

Graphical View of Domain Structure for InterPro Entry

Q8N1G2

UniProtKB/Swiss-Prot:

CMTR1_HUMAN :
  • Q8N1G2
Domain:
  • Contains 1 G-patch domain.
  • Contains 1 RrmJ-type SAM-dependent 2-O-MTase domain.
  • Contains 1 WW domain.
genes like me logo Genes that share domains with CMTR1: view

No data available for Suggested Antigen Peptide Sequences for CMTR1 Gene

Function for CMTR1 Gene

Molecular function for CMTR1 Gene

UniProtKB/Swiss-Prot CatalyticActivity: S-adenosyl-L-methionine + a 5-(N(7)-methyl 5-triphosphoguanosine)-(purine-ribonucleotide)-(mRNA) = S-adenosyl-L-homocysteine + a 5-(N(7)-methyl 5-triphosphoguanosine)-(2-O-methyl-purine-ribonucleotide)-(mRNA).
UniProtKB/Swiss-Prot Function: S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap1 2-O-ribose methylation to the 5-cap structure of mRNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA and small nuclear RNA (snRNA) to produce m(7)GpppRm (cap1). Displays a preference for cap0 transcripts. Cap1 modification is linked to higher levels of translation. May be involved in the interferon response pathway.
UniProtKB/Swiss-Prot Induction: By interferons alpha and beta, and by Vaccinia virus infection.

Enzyme Numbers (IUBMB) for CMTR1 Gene

Gene Ontology (GO) - Molecular Function for CMTR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0004483 mRNA (nucleoside-2-O-)-methyltransferase activity IDA 20713356
GO:0005515 protein binding --
GO:0008168 methyltransferase activity --
genes like me logo Genes that share ontologies with CMTR1: view

Phenotypes for CMTR1 Gene

GenomeRNAi human phenotypes for CMTR1:
genes like me logo Genes that share phenotypes with CMTR1: view

Animal Model Products

CRISPR Products

miRNA for CMTR1 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CMTR1

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for CMTR1 Gene

Localization for CMTR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CMTR1 Gene

Gene Ontology (GO) - Cellular Components for CMTR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21310715
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with CMTR1: view

No data available for Subcellular locations from COMPARTMENTS for CMTR1 Gene

Pathways for CMTR1 Gene

SuperPathways for CMTR1 Gene

No Data Available

Interacting Proteins for CMTR1 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000362550%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000336741%0d%0a
Selected Interacting proteins: ENSP00000362550 Q8N1G2-CMTR1_HUMAN for CMTR1 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for CMTR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006370 7-methylguanosine mRNA capping IMP 20713356
GO:0032259 methylation --
GO:0080009 mRNA methylation IDA 20713356
GO:0097309 cap1 mRNA methylation IDA 21310715
genes like me logo Genes that share ontologies with CMTR1: view

No data available for Pathways by source for CMTR1 Gene

Transcripts for CMTR1 Gene

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CMTR1

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CMTR1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a · 21b ^ 22a · 22b ^
SP1: - - - - - -
SP2: - - - -
SP3: - - - - -
SP4:
SP5:
SP6:
SP7:
SP8: - -
SP9:

ExUns: 23a · 23b ^ 24a · 24b ^ 25 ^ 26a · 26b ^ 27
SP1: - -
SP2:
SP3:
SP4: - -
SP5:
SP6: - - -
SP7:
SP8:
SP9:

Relevant External Links for CMTR1 Gene

GeneLoc Exon Structure for
CMTR1
ECgene alternative splicing isoforms for
CMTR1

Expression for CMTR1 Gene

mRNA expression in normal human tissues for CMTR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CMTR1 Gene

genes like me logo Genes that share expressions with CMTR1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CMTR1 Gene

Orthologs for CMTR1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CMTR1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FTSJD2 35
  • 99.84 (n)
  • 100 (a)
FTSJD2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CMTR1 35
  • 91.26 (n)
  • 95.21 (a)
FTSJD2 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CMTR1 36
  • 97 (a)
OneToOne
FTSJD2 35
  • 92.38 (n)
  • 96.89 (a)
mouse
(Mus musculus)
Mammalia Cmtr1 35
  • 87.3 (n)
  • 90.38 (a)
Cmtr1 36
  • 90 (a)
OneToOne
Ftsjd2 16
platypus
(Ornithorhynchus anatinus)
Mammalia CMTR1 36
  • 81 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cmtr1 35
  • 86.66 (n)
  • 90.26 (a)
chicken
(Gallus gallus)
Aves CMTR1 36
  • 84 (a)
OneToOne
FTSJD2 35
  • 76.72 (n)
  • 84.56 (a)
lizard
(Anolis carolinensis)
Reptilia CMTR1 36
  • 81 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.7896 35
zebrafish
(Danio rerio)
Actinopterygii cmtr1 35
  • 67.44 (n)
  • 71.48 (a)
cmtr1 36
  • 71 (a)
OneToOne
zgc55336 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000826 35
  • 52.41 (n)
  • 42.76 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG6379 35
  • 50 (n)
  • 40.41 (a)
CG6379 36
  • 36 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea CELE_Y53F4B.13 35
  • 51.75 (n)
  • 42.9 (a)
Y53F4B.13 36
  • 31 (a)
OneToOne
Species with no ortholog for CMTR1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for CMTR1 Gene

ENSEMBL:
Gene Tree for CMTR1 (if available)
TreeFam:
Gene Tree for CMTR1 (if available)

Paralogs for CMTR1 Gene

Paralogs for CMTR1 Gene

Selected SIMAP similar genes for CMTR1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with CMTR1: view

Variants for CMTR1 Gene

Sequence variations from dbSNP and Humsavar for CMTR1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs14217 -- 37,481,033(+) GTCTG(C/T)CATAG utr-variant-3-prime, intron-variant
rs904249 -- 37,462,712(-) TAGGC(C/T)TACGC intron-variant
rs904250 -- 37,461,709(-) GTACA(C/T)GTTCT intron-variant
rs914350 -- 37,454,661(+) TAGAG(A/G)TGTTA intron-variant
rs1224127 -- 37,449,780(-) TGTTA(C/T)TCAAA intron-variant

Relevant External Links for CMTR1 Gene

HapMap Linkage Disequilibrium report
CMTR1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CMTR1 Gene

Disorders for CMTR1 Gene

No disorders were found for CMTR1 Gene.

No data available for UniProtKB/Swiss-Prot for CMTR1 Gene

Publications for CMTR1 Gene

  1. Characterization of hMTr1, a human Cap1 2'-O-Ribose methyltransferase. (PMID: 20713356) Belanger F. … Pelletier J. (J. Biol. Chem. 2010) 2 3 4
  2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4
  3. Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1. (PMID: 7788527) Nagase T. … Nomura N. (DNA Res. 1995) 3 4
  4. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for CMTR1 Gene

Sources for CMTR1 Gene

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