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Aliases for CMTM8 Gene

Aliases for CMTM8 Gene

  • CKLF Like MARVEL Transmembrane Domain Containing 8 2 3
  • CKLF-Like MARVEL Transmembrane Domain Containing 8 2 5
  • Chemokine-Like Factor Superfamily Member 8 3 4
  • CKLFSF8 3 4
  • Chemokine-Like Factor Super Family 8 2
  • Chemokine-Like Factor Superfamily 8 2
  • CKLFSF8-V2 3

External Ids for CMTM8 Gene

Previous HGNC Symbols for CMTM8 Gene


Previous GeneCards Identifiers for CMTM8 Gene

  • GC03P032256
  • GC03P032217
  • GC03P032280

Summaries for CMTM8 Gene

Entrez Gene Summary for CMTM8 Gene

  • This gene belongs to the chemokine-like factor gene superfamily, a novel family that is similar to the chemokine and the transmembrane 4 superfamilies. This gene is one of several chemokine-like factor genes located in a cluster on chromosome 3. This gene acts as a tumor suppressor, and plays a role in regulating the migration of tumor cells. The encoded protein is thought to function as a a negative regulator of epidermal growth factor-induced signaling. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2016]

GeneCards Summary for CMTM8 Gene

CMTM8 (CKLF Like MARVEL Transmembrane Domain Containing 8) is a Protein Coding gene. GO annotations related to this gene include cytokine activity. An important paralog of this gene is PLLP.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CMTM8 Gene

Genomics for CMTM8 Gene

Regulatory Elements for CMTM8 Gene

Enhancers for CMTM8 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CMTM8 on UCSC Golden Path with GeneCards custom track

Promoters for CMTM8 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CMTM8 on UCSC Golden Path with GeneCards custom track

Genomic Location for CMTM8 Gene

32,238,679 bp from pter
32,370,325 bp from pter
131,647 bases
Plus strand

Genomic View for CMTM8 Gene

Genes around CMTM8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CMTM8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CMTM8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CMTM8 Gene

Proteins for CMTM8 Gene

  • Protein details for CMTM8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    CKLF-like MARVEL transmembrane domain-containing protein 8
    Protein Accession:
    Secondary Accessions:
    • A5D6I7
    • Q8IW01

    Protein attributes for CMTM8 Gene

    173 amino acids
    Molecular mass:
    19572 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CMTM8 Gene


neXtProt entry for CMTM8 Gene

Proteomics data for CMTM8 Gene at MOPED

Post-translational modifications for CMTM8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CMTM8 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cloud-Clone Corp. Antibodies for CMTM8

No data available for DME Specific Peptides for CMTM8 Gene

Domains & Families for CMTM8 Gene

Gene Families for CMTM8 Gene

Protein Domains for CMTM8 Gene


Suggested Antigen Peptide Sequences for CMTM8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 MARVEL domain.
  • Belongs to the chemokine-like factor family.
  • Contains 1 MARVEL domain.
  • Belongs to the chemokine-like factor family.
genes like me logo Genes that share domains with CMTM8: view

Function for CMTM8 Gene

Phenotypes for CMTM8 Gene

GenomeRNAi human phenotypes for CMTM8:
genes like me logo Genes that share phenotypes with CMTM8: view

Animal Model Products

miRNA for CMTM8 Gene

miRTarBase miRNAs that target CMTM8

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CMTM8 Gene

Localization for CMTM8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CMTM8 Gene

Isoform 1: Membrane; Multi-pass membrane protein.
Isoform 2: Cytoplasm. Nucleus.

Subcellular locations from

Jensen Localization Image for CMTM8 Gene COMPARTMENTS Subcellular localization image for CMTM8 gene
Compartment Confidence
nucleus 5
extracellular 3
plasma membrane 3

Gene Ontology (GO) - Cellular Components for CMTM8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CMTM8: view

Pathways & Interactions for CMTM8 Gene

SuperPathways for CMTM8 Gene

No Data Available

Interacting Proteins for CMTM8 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: Q8IZV2-CKLF8_HUMAN ENSP00000307741 for CMTM8 Gene via MINT STRING UniProtKB I2D

Gene Ontology (GO) - Biological Process for CMTM8 Gene


No data available for Pathways by source and SIGNOR curated interactions for CMTM8 Gene

Drugs & Compounds for CMTM8 Gene

No Compound Related Data Available

Transcripts for CMTM8 Gene

mRNA/cDNA for CMTM8 Gene

Unigene Clusters for CMTM8 Gene

CKLF-like MARVEL transmembrane domain containing 8:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CMTM8 Gene

No ASD Table

Relevant External Links for CMTM8 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CMTM8 Gene

mRNA expression in normal human tissues for CMTM8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CMTM8 Gene

This gene is overexpressed in Liver (x5.6) and Pancreas (x5.3).

Protein differential expression in normal tissues from HIPED for CMTM8 Gene

This gene is overexpressed in Spleen (51.4) and Islet of Langerhans (17.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for CMTM8 Gene

SOURCE GeneReport for Unigene cluster for CMTM8 Gene Hs.154986

mRNA Expression by UniProt/SwissProt for CMTM8 Gene

Tissue specificity: Highly expressed in liver and pancreas.
genes like me logo Genes that share expression patterns with CMTM8: view

Protein tissue co-expression partners for CMTM8 Gene

Primer Products

Orthologs for CMTM8 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CMTM8 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CMTM8 35
  • 91.91 (n)
  • 95.38 (a)
CMTM8 36
  • 95 (a)
(Canis familiaris)
Mammalia CMTM8 35
  • 94.03 (n)
  • 98.84 (a)
CMTM8 36
  • 99 (a)
(Mus musculus)
Mammalia Cmtm8 35
  • 86.71 (n)
  • 92.49 (a)
Cmtm8 16
Cmtm8 36
  • 90 (a)
(Pan troglodytes)
Mammalia CMTM8 35
  • 99.81 (n)
  • 99.42 (a)
CMTM8 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Cmtm8 35
  • 87.28 (n)
  • 91.33 (a)
(Monodelphis domestica)
Mammalia CMTM8 36
  • 46 (a)
(Ornithorhynchus anatinus)
Mammalia CMTM8 36
  • 77 (a)
(Gallus gallus)
Aves CMTM8 35
  • 79 (n)
  • 82.66 (a)
CMTM8 36
  • 86 (a)
(Anolis carolinensis)
Reptilia CMTM8 36
  • 72 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cmtm8 35
  • 67.26 (n)
  • 65.48 (a)
Str.18775 35
(Danio rerio)
Actinopterygii zgc:158657 35
  • 61.01 (n)
  • 50.29 (a)
CMTM8 36
  • 47 (a)
Species with no ortholog for CMTM8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CMTM8 Gene

Gene Tree for CMTM8 (if available)
Gene Tree for CMTM8 (if available)

Paralogs for CMTM8 Gene

Paralogs for CMTM8 Gene

(3) SIMAP similar genes for CMTM8 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CMTM8: view

Variants for CMTM8 Gene

Sequence variations from dbSNP and Humsavar for CMTM8 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs726911 -- 32,332,239(-) TGCTG(C/G)GTCCA intron-variant
rs749948 -- 32,346,509(+) gtgtc(C/T)ggtga intron-variant
rs752898 -- 32,311,243(-) acaaa(C/G)tgcaa intron-variant
rs764125 -- 32,342,843(-) CACAA(C/G)AGTGC intron-variant
rs1077868 -- 32,347,212(-) AATCA(C/T)TGTTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CMTM8 Gene

Variant ID Type Subtype PubMed ID
nsv876676 CNV Gain 21882294
esv2676585 CNV Deletion 23128226
esv23045 CNV Loss 19812545
esv271280 CNV Insertion 20981092
nsv526741 CNV Loss 19592680
esv2511457 CNV Deletion 19546169
nsv236546 CNV Loss 16902084

Variation tolerance for CMTM8 Gene

Residual Variation Intolerance Score: 64.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.00; 36.95% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for CMTM8 Gene

Disorders for CMTM8 Gene

Relevant External Links for CMTM8

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CMTM8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CMTM8 Gene

Publications for CMTM8 Gene

  1. An alternative splice form of CMTM8 induces apoptosis. (PMID: 17681841) Li D. … Wang Y. (Int. J. Biochem. Cell Biol. 2007) 3 4 23 67
  2. [Effect of novel human chemokine-like factor superfamily 8 on proliferation and EGFR expression of tumor cells]. (PMID: 16806010) Huang Y.M. … Du Y. (Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2006) 3 23
  3. Regulation of EGF receptor signaling by the MARVEL domain-containing protein CKLFSF8. (PMID: 16263120) Jin C. … Ma D. (FEBS Lett. 2005) 3 23
  4. Identification of eight genes encoding chemokine-like factor superfamily members 1-8 (CKLFSF1-8) by in silico cloning and experimental validation. (PMID: 12782130) Han W. … Ma D. (Genomics 2003) 3 23
  5. CMTM8 is Frequently Downregulated in Multiple Solid Tumors. (PMID: 26574634) Zhang W. … Wang Y. (Appl. Immunohistochem. Mol. Morphol. 2015) 3

Products for CMTM8 Gene

Sources for CMTM8 Gene