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CMTM8 Gene

protein-coding   GIFtS: 50
GCID: GC03P032280

CKLF-Like MARVEL Transmembrane Domain Containing 8

(Previous names: chemokine-like factor super family 8, chemokine-like factor...)
(Previous symbol: CKLFSF8)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
CKLF-Like MARVEL Transmembrane Domain Containing 81 2     Chemokine-Like Factor Superfamily Member 82 3
CKLFSF81 2 3 5     CKLFSF8-V22
Chemokine-Like Factor Super Family 81 2     CKLF-Like MARVEL Transmembrane Domain-Containing Protein 82
Chemokine-Like Factor Superfamily 81 2     

External Ids:    HGNC: 191791   Entrez Gene: 1521892   Ensembl: ENSG000001702937   OMIM: 6078915   UniProtKB: Q8IZV23   

Export aliases for CMTM8 gene to outside databases

Previous GC identifers: GC03P032256 GC03P032217


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CMTM8 Gene:
This gene belongs to the chemokine-like factor gene superfamily, a novel family that is similar to the chemokine
and the transmembrane 4 superfamilies. This gene is one of several chemokine-like factor genes located in a
cluster on chromosome 3. This gene is widely expressed in many tissues, but the exact function of the encoded
protein is unknown. (provided by RefSeq, Jul 2008)

GeneCards Summary for CMTM8 Gene:
CMTM8 (CKLF-like MARVEL transmembrane domain containing 8) is a protein-coding gene. GO annotations related to this gene include cytokine activity. An important paralog of this gene is PLLP.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NC_018914.2  NT_022517.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the CMTM8 gene promoter:
         Max1   MIF-1   AP-2gamma   Evi-1   Arnt   E2F-1   E2F   Cart-1   Pax-4a   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCMTM8 promoter sequence
   Search Chromatin IP Primers for CMTM8

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CMTM8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p22.3   Ensembl cytogenetic band:  3p22.3   HGNC cytogenetic band: 3p22.2

CMTM8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CMTM8 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P032280:  view genomic region     (about GC identifiers)

Start:
32,280,171 bp from pter      End:
32,411,817 bp from pter
Size:
131,647 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CKLF8_HUMAN, Q8IZV2 (See protein sequence)
Recommended Name: CKLF-like MARVEL transmembrane domain-containing protein 8  
Size: 173 amino acids; 19572 Da
Secondary accessions: A5D6I7 Q8IW01
Alternative splicing: 2 isoforms:  Q8IZV2-1   Q8IZV2-2   

Explore the universe of human proteins at neXtProt for CMTM8: NX_Q8IZV2

Explore proteomics data for CMTM8 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CMTM8 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_849199.2  
    ENSEMBL proteins: 
     ENSP00000412934   ENSP00000307741  

    CMTM8 Human Recombinant Protein Products:

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    Browse Proteins at Cloud-Clone Corp.

     
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    antibodies-online proteins for CMTM8 (5 products) 

     
    antibodies-online peptides for CMTM8

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    antibodies-online antibodies for CMTM8 (16 products) 

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    antibodies-online kits for CMTM8 (24 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR013295 MAL
     IPR008253 Marvel

    Graphical View of Domain Structure for InterPro Entry Q8IZV2

    ProtoNet protein and cluster: Q8IZV2

    1 Blocks protein domain: IPB008253 Marvel

    UniProtKB/Swiss-Prot: CKLF8_HUMAN, Q8IZV2
    Similarity: Belongs to the chemokine-like factor family
    Similarity: Contains 1 MARVEL domain


    Find genes that share domains with CMTM8           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005125cytokine activity IEA--
         
    Find genes that share ontologies with CMTM8           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for CMTM8

    miRNA
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    miRTarBase miRNAs that target CMTM8:
    hsa-mir-877-5p (MIRT037344)

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    4 qRT-PCR Assays for microRNAs that regulate CMTM8:
    hsa-miR-323-3p hsa-miR-495 hsa-miR-3613-3p hsa-miR-3144-3p
    SwitchGear 3'UTR luciferase reporter plasmidCMTM8 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CMTM8

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CKLF8_HUMAN, Q8IZV2: Isoform 1: Membrane; Multi-pass membrane protein
    CKLF8_HUMAN, Q8IZV2: Isoform 2: Cytoplasm. Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    extracellular3
    plasma membrane3

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IEA--
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--
    GO:0016020membrane ----
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with CMTM8           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CMTM8
    Interactions:

        Search GeneGlobe Interaction Network for CMTM8

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for CMTM8 (Q8IZV22, 3 ENSP000003077414) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EGFRP005332, 3, ENSP000002754934MINT-72808 MINT-72809 MINT-72810 I2D: score=2 STRING: ENSP00000275493
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    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006935chemotaxis IEA--

    Find genes that share ontologies with CMTM8           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CMTM8 (CKLF8)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CMTM8 gene: 
    NM_178868.3  

    Unigene Cluster for CMTM8:

    CKLF-like MARVEL transmembrane domain containing 8
    Hs.154986  [show with all ESTs]
    Unigene Representative Sequence: NM_178868
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000458535(uc010hfu.3) ENST00000307526(uc003cex.3)
    miRNA
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    4 qRT-PCR Assays for microRNAs that regulate CMTM8:
    hsa-miR-323-3p hsa-miR-495 hsa-miR-3613-3p hsa-miR-3144-3p
    SwitchGear 3'UTR luciferase reporter plasmidCMTM8 3' UTR sequence
    Inhib. RNA
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    Primer
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    OriGene qPCR primer pairs and template standards for CMTM8
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      QuantiTect SYBR Green Assays in human, mouse, rat CMTM8
      QuantiFast Probe-based Assays in human, mouse, rat CMTM8

    Additional mRNA sequence: 

    AF474370.2 AY598783.1 BC041390.2 

    3 DOTS entries:

    DT.100023114  DT.100023113  DT.100746081 

    Selected AceView cDNA sequences (see all 45):

    AW024144 CB070190 BQ224486 AI197788 BM785932 NM_178868 AF474370 AV660309 
    BE869501 BG189930 BU506617 BG213702 BQ186760 BC041390 CB243247 BM663331 
    BG182013 BM554032 BU075644 BG656425 BI791855 BF793712 BG216957 AI564525 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CMTM8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CMTM8 Expression
    About this image


    CMTM8 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 10) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Metencephalon
     
     Neural Crest (Gastrulation Derivatives)
             PureStem MEL2, NCr-fac Progenitor
     
     Bone (Muscoskeletal System)
             HyStem+BMP4-induced E15 cells
     
     Cartilage (Muscoskeletal System)
             HyStem+BMP4-induced E15 cells
     
     Eye (Sensory Organs)
             Cholinergic Amacrine Cells Inner Nuclear Layer
    CMTM8 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CMTM8 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.154986

    UniProtKB/Swiss-Prot: CKLF8_HUMAN, Q8IZV2
    Tissue specificity: Highly expressed in liver and pancreas

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CMTM8 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cmtm81 , 5 CKLF-like MARVEL transmembrane domain containing 81, 5 86.71(n)1
    92.49(a)1
      9 (65.20 cM)5
    700311  NM_027294.21  NP_081570.11 
     1147893455 
    chicken
    (Gallus gallus)
    Aves CMTM81 CKLF-like MARVEL transmembrane domain containing 8 79(n)
    82.66(a)
      420665  NM_001199703.1  NP_001186632.1 
    lizard
    (Anolis carolinensis)
    Reptilia CMTM86
    CKLF-like MARVEL transmembrane domain containing 8...
    72(a)
    1 ↔ 1
    1(193613576-193646122)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.187752 Transcribed sequence with weak similarity to protein more 84.11(n)    AL846822.2 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1586571 zgc:158657 61.01(n)
    50.29(a)
      791163  NM_001080645.1  NP_001074114.1 


    ENSEMBL Gene Tree for CMTM8 (if available)
    TreeFam Gene Tree for CMTM8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CMTM8 gene
    PLLP2  
    3 SIMAP similar genes for CMTM8 using alignment to 1 protein entry:     CKLF8_HUMAN:
    PLLP    MALL    MAL

    Find genes that share paralogs with CMTM8           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CMTM8 (see all 2733)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs39247071,2
    C,F--32278202(-) CTGCAA/GTGTAA 1 -- us2k13Minor allele frequency- G:0.06WA NA EA 358
    rs98131461,2
    C,A--32278225(+) GCATAC/TACTTA 1 -- us2k13Minor allele frequency- T:0.21NA WA 122
    rs1811913221,2
    --32278370(+) ATTCAA/TCTGAC 1 -- us2k10--------
    rs49552681,2
    C,A,H--32278646(+) ggggtA/Ggggct 1 -- us2k19Minor allele frequency- G:0.40NA WA EA 374
    rs49552691,2
    C,H--32278809(+) GGAATT/CTCTCC 1 -- us2k114Minor allele frequency- C:0.05NS EA NA CSA WA 664
    rs1425368411,2
    C--32278831(+) TTTGCC/TATGCT 1 -- us2k10--------
    rs1856053941,2
    --32278929(+) TTGTCA/GTTTTT 1 -- us2k10--------
    rs1382207441,2
    C--32278935(+) TTTTT-/GCTTTC 1 -- us2k10--------
    rs98379231,2
    C,F,H--32278965(+) GACACT/CGTGAA 1 -- us2k120Minor allele frequency- C:0.44NS EA NA CSA WA 2344
    rs98382231,2
    C,F,A,H--32279180(+) CCATCT/GGTCAA 1 -- us2k121Minor allele frequency- G:0.43NS EA NA WA 2348

    HapMap Linkage Disequilibrium report for CMTM8 (32280171 - 32411817 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for CMTM8:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2511457CNV Deletion19546169
    esv2676585CNV Deletion23128226
    esv271280CNV Insertion20981092
    esv23045CNV Loss19812545
    nsv236546CNV Loss16902084
    nsv526741CNV Loss19592680
    nsv876676CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CMTM8
    DNA2.0 Custom Variant and Variant Library Synthesis for CMTM8

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607891    OMIM disorders: --


    Find genes that share disorders with CMTM8           About GenesLikeMe

    Genetic Association Database (GAD): CMTM8
    Human Genome Epidemiology (HuGE) Navigator: CMTM8 (3 documents)

    Export disorders for CMTM8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CMTM8 gene, integrated from 10 sources (see all 16):
    (articles sorted by number of sources associating them with CMTM8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. An alternative splice form of CMTM8 induces apoptosis. (PubMed id 17681841)1, 2, 9 Li D....Wang Y. (Int. J. Biochem. Cell Biol. 2007)
    2. Identification of eight genes encoding chemokine-like factor superfamily members 1-8 (CKLFSF1-8) by in silico cloning and experimental validation. (PubMed id 12782130)1, 2, 9 Han W.... Ma D. (Genomics 2003)
    3. Genomewide association study for determinants of HIV-1 acquisition and viral set point in HIV-1 serodiscordant couples with quantified virus exposure. (PubMed id 22174851)1, 4 Lingappa J.R....Goldstein D. (PLoS ONE 2011)
    4. Propensity score-based nonparametric test revealing genetic variants underlying bipolar disorder. (PubMed id 21254220)1, 4 Jiang Y. and Zhang H. (Genet. Epidemiol. 2011)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    6. Findings from bipolar disorder genome-wide association studies replicate in a Finnish bipolar family-cohort. (PubMed id 19308021)1, 4 Ollila H.M....Paunio T. (Mol. Psychiatry 2009)
    7. Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder. (PubMed id 18711365)1, 4 Ferreira M.A....Craddock N. (Nat. Genet. 2008)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Regulation of EGF receptor signaling by the MARVEL domain-containing protein CKLFSF8. (PubMed id 16263120)1, 9 Jin C....Ma D. (FEBS Lett. 2005)
    10. [Effect of novel human chemokine-like factor superfamily 8 on proliferation and EGFR expression of tumor cells]. (PubMed id 16806010)1, 9 Huang Y.M. and Du Y. (Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 152189 HGNC: 19179 AceView: CKLFSF8 Ensembl:ENSG00000170293 euGenes: HUgn152189
    ECgene: CMTM8 H-InvDB: CMTM8

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CMTM8 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CMTM8 gene:
    Search GeneIP for patents involving CMTM8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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