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Aliases for CMTM8 Gene

Aliases for CMTM8 Gene

  • CKLF-Like MARVEL Transmembrane Domain Containing 8 2 3
  • CKLFSF8 3 4 6
  • Chemokine-Like Factor Superfamily Member 8 3 4
  • Chemokine-Like Factor Super Family 8 2 3
  • Chemokine-Like Factor Superfamily 8 2 3
  • CKLF-Like MARVEL Transmembrane Domain-Containing Protein 8 3
  • CKLFSF8-V2 3

External Ids for CMTM8 Gene

Previous HGNC Symbols for CMTM8 Gene

  • CKLFSF8

Previous GeneCards Identifiers for CMTM8 Gene

  • GC03P032256
  • GC03P032217
  • GC03P032280

Summaries for CMTM8 Gene

Entrez Gene Summary for CMTM8 Gene

  • This gene belongs to the chemokine-like factor gene superfamily, a novel family that is similar to the chemokine and the transmembrane 4 superfamilies. This gene is one of several chemokine-like factor genes located in a cluster on chromosome 3. This gene is widely expressed in many tissues, but the exact function of the encoded protein is unknown. [provided by RefSeq, Jul 2008]

GeneCards Summary for CMTM8 Gene

CMTM8 (CKLF-Like MARVEL Transmembrane Domain Containing 8) is a Protein Coding gene. GO annotations related to this gene include cytokine activity. An important paralog of this gene is PLLP.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CMTM8 Gene

Genomics for CMTM8 Gene

Regulatory Elements for CMTM8 Gene

Genomic Location for CMTM8 Gene

Start:
32,238,679 bp from pter
End:
32,370,325 bp from pter
Size:
131,647 bases
Orientation:
Plus strand

Genomic View for CMTM8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CMTM8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CMTM8 Gene

Proteins for CMTM8 Gene

  • Protein details for CMTM8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IZV2-CKLF8_HUMAN
    Recommended name:
    CKLF-like MARVEL transmembrane domain-containing protein 8
    Protein Accession:
    Q8IZV2
    Secondary Accessions:
    • A5D6I7
    • Q8IW01

    Protein attributes for CMTM8 Gene

    Size:
    173 amino acids
    Molecular mass:
    19572 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CMTM8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CMTM8 Gene

Proteomics data for CMTM8 Gene at MOPED

Post-translational modifications for CMTM8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CMTM8 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CMTM8 Gene

Domains for CMTM8 Gene

Protein Domains for CMTM8 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for CMTM8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IZV2

UniProtKB/Swiss-Prot:

CKLF8_HUMAN :
  • Q8IZV2
Domain:
  • Contains 1 MARVEL domain.
Family:
  • Belongs to the chemokine-like factor family.
genes like me logo Genes that share domains with CMTM8: view

No data available for Gene Families for CMTM8 Gene

Function for CMTM8 Gene

Gene Ontology (GO) - Molecular Function for CMTM8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IEA --
genes like me logo Genes that share ontologies with CMTM8: view

miRNA for CMTM8 Gene

miRTarBase miRNAs that target CMTM8

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for CMTM8 Gene

Localization for CMTM8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CMTM8 Gene

Isoform 1: Membrane; Multi-pass membrane protein.
Isoform 2: Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CMTM8 Gene COMPARTMENTS Subcellular localization image for CMTM8 gene
Compartment Confidence
nucleus 5
extracellular 3
plasma membrane 3

Gene Ontology (GO) - Cellular Components for CMTM8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IEA --
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CMTM8: view

Pathways for CMTM8 Gene

SuperPathways for CMTM8 Gene

No Data Available

Interacting Proteins for CMTM8 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000307741%0d%0a9606.ENSP00000275493%0d%0a
Selected Interacting proteins: Q8IZV2-CKLF8_HUMAN ENSP00000307741 for CMTM8 Gene via MINT STRING I2D

Gene Ontology (GO) - Biological Process for CMTM8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006935 chemotaxis IEA --
genes like me logo Genes that share ontologies with CMTM8: view

No data available for Pathways by source for CMTM8 Gene

Transcripts for CMTM8 Gene

mRNA/cDNA for CMTM8 Gene

Unigene Clusters for CMTM8 Gene

CKLF-like MARVEL transmembrane domain containing 8:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CMTM8 Gene

No ASD Table

Relevant External Links for CMTM8 Gene

GeneLoc Exon Structure for
CMTM8
ECgene alternative splicing isoforms for
CMTM8

Expression for CMTM8 Gene

mRNA expression in normal human tissues for CMTM8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CMTM8 Gene

This gene is overexpressed in Liver (5.6) and Pancreas (5.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CMTM8 Gene

SOURCE GeneReport for Unigene cluster for CMTM8 Gene Hs.154986

mRNA Expression by UniProt/SwissProt for CMTM8 Gene

Q8IZV2-CKLF8_HUMAN
Tissue specificity: Highly expressed in liver and pancreas.
genes like me logo Genes that share expressions with CMTM8: view

Orthologs for CMTM8 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CMTM8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CMTM8 35
  • 99.81 (n)
  • 99.42 (a)
CMTM8 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CMTM8 35
  • 91.91 (n)
  • 95.38 (a)
CMTM8 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CMTM8 35
  • 94.03 (n)
  • 98.84 (a)
CMTM8 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cmtm8 35
  • 86.71 (n)
  • 92.49 (a)
Cmtm8 16
Cmtm8 36
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CMTM8 36
  • 46 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CMTM8 36
  • 77 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cmtm8 35
  • 87.28 (n)
  • 91.33 (a)
chicken
(Gallus gallus)
Aves CMTM8 35
  • 79 (n)
  • 82.66 (a)
CMTM8 36
  • 86 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CMTM8 36
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cmtm8 35
  • 67.26 (n)
  • 65.48 (a)
Str.18775 35
zebrafish
(Danio rerio)
Actinopterygii CMTM8 36
  • 47 (a)
OneToOne
zgc:158657 35
  • 61.01 (n)
  • 50.29 (a)
Species with no ortholog for CMTM8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CMTM8 Gene

ENSEMBL:
Gene Tree for CMTM8 (if available)
TreeFam:
Gene Tree for CMTM8 (if available)

Paralogs for CMTM8 Gene

Paralogs for CMTM8 Gene

Selected SIMAP similar genes for CMTM8 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CMTM8: view

Variants for CMTM8 Gene

Sequence variations from dbSNP and Humsavar for CMTM8 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs726911 -- 32,332,239(-) TGCTG(C/G)GTCCA intron-variant
rs749948 -- 32,346,509(+) gtgtc(C/T)ggtga intron-variant
rs752898 -- 32,311,243(-) acaaa(C/G)tgcaa intron-variant
rs764125 -- 32,342,843(-) CACAA(C/G)AGTGC intron-variant
rs1077868 -- 32,347,212(-) AATCA(C/T)TGTTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CMTM8 Gene

Variant ID Type Subtype PubMed ID
nsv876676 CNV Gain 21882294
esv2676585 CNV Deletion 23128226
esv23045 CNV Loss 19812545
esv271280 CNV Insertion 20981092
nsv526741 CNV Loss 19592680
esv2511457 CNV Deletion 19546169
nsv236546 CNV Loss 16902084

Relevant External Links for CMTM8 Gene

HapMap Linkage Disequilibrium report
CMTM8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CMTM8 Gene

Disorders for CMTM8 Gene

Relevant External Links for CMTM8

Genetic Association Database (GAD)
CMTM8
Human Genome Epidemiology (HuGE) Navigator
CMTM8
genes like me logo Genes that share disorders with CMTM8: view

No data available for UniProtKB/Swiss-Prot for CMTM8 Gene

Publications for CMTM8 Gene

  1. Identification of eight genes encoding chemokine-like factor superfamily members 1-8 (CKLFSF1-8) by in silico cloning and experimental validation. (PMID: 12782130) Han W. … Ma D. (Genomics 2003) 3 4 23
  2. An alternative splice form of CMTM8 induces apoptosis. (PMID: 17681841) Li D. … Wang Y. (Int. J. Biochem. Cell Biol. 2007) 3 4 23
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Regulation of EGF receptor signaling by the MARVEL domain-containing protein CKLFSF8. (PMID: 16263120) Jin C. … Ma D. (FEBS Lett. 2005) 3 23
  5. [Effect of novel human chemokine-like factor superfamily 8 on proliferation and EGFR expression of tumor cells]. (PMID: 16806010) Huang Y.M. … Du Y. (Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2006) 3 23

Products for CMTM8 Gene

Sources for CMTM8 Gene

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