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Aliases for CMTM7 Gene

Aliases for CMTM7 Gene

  • CKLF Like MARVEL Transmembrane Domain Containing 7 2 3 5
  • Chemokine-Like Factor Superfamily Member 7 3 4
  • Chemokine-Like Factor Super Family 7 2 3
  • Chemokine-Like Factor Superfamily 7 2 3
  • CKLFSF7 3 4
  • CKLF-Like MARVEL Transmembrane Domain-Containing Protein 7 3
  • Chemokine-Like Factor Super Family Member 7 Variant 2 3
  • CKLF-Like MARVEL Transmembrane Domain Containing 7 2

External Ids for CMTM7 Gene

Previous HGNC Symbols for CMTM7 Gene


Summaries for CMTM7 Gene

Entrez Gene Summary for CMTM7 Gene

  • This gene belongs to the chemokine-like factor gene superfamily, a novel family that is similar to the chemokine and transmembrane 4 superfamilies. This gene is one of several chemokine-like factor genes located in a cluster on chromosome 3. This gene acts as a tumor suppressor that regulates G1/S transition in the cell cycle, and epidermal growth factor receptor/protein kinase B signaling during tumor pathogenesis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2016]

GeneCards Summary for CMTM7 Gene

CMTM7 (CKLF Like MARVEL Transmembrane Domain Containing 7) is a Protein Coding gene. GO annotations related to this gene include cytokine activity.

Additional gene information for CMTM7 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CMTM7 Gene

Genomics for CMTM7 Gene

Regulatory Elements for CMTM7 Gene

Enhancers for CMTM7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03H032397 1.8 FANTOM5 Ensembl ENCODE dbSUPER 18 +9.2 9200 6.1 PKNOX1 RB1 MLX ARID4B SIN3A DMAP1 DNMT3B ZSCAN9 RAD21 YY1 CMTM7 GC03M031988
GH03H032418 1.8 FANTOM5 Ensembl ENCODE dbSUPER 17.1 +30.6 30613 6.8 PKNOX1 FEZF1 DMAP1 ZNF2 YY1 FOS ATF7 RUNX3 JUNB ZNF585B CMTM7 CMTM6 CNOT10 RPL31P18 DYNC1LI1 GC03M031988 GC03P032466
GH03H032406 1.1 Ensembl ENCODE dbSUPER 15.3 +16.1 16084 3.3 ZNF146 GATA3 FOXA2 EED HLF ETV6 RUNX3 ZBTB20 CMTM7 GC03M031988 GC03P032466
GH03H032430 1.7 FANTOM5 Ensembl ENCODE dbSUPER 8.8 +40.8 40786 3.3 PKNOX1 TBL1XR1 SIN3A FEZF1 CEBPG ZFHX2 POLR2A ATF7 RUNX3 IKZF2 CMTM6 RPL31P18 DYNC1LI1 CMTM7 GC03M031988 GC03P032466
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CMTM7 on UCSC Golden Path with GeneCards custom track

Promoters for CMTM7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Locations for CMTM7 Gene

Genomic Locations for CMTM7 Gene
91,397 bases
Plus strand

Genomic View for CMTM7 Gene

Genes around CMTM7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CMTM7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CMTM7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CMTM7 Gene

Proteins for CMTM7 Gene

  • Protein details for CMTM7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    CKLF-like MARVEL transmembrane domain-containing protein 7
    Protein Accession:
    Secondary Accessions:
    • Q5VLK1

    Protein attributes for CMTM7 Gene

    175 amino acids
    Molecular mass:
    18834 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CMTM7 Gene


neXtProt entry for CMTM7 Gene

Post-translational modifications for CMTM7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CMTM7 Gene

No data available for DME Specific Peptides for CMTM7 Gene

Domains & Families for CMTM7 Gene

Gene Families for CMTM7 Gene

Protein Domains for CMTM7 Gene


Suggested Antigen Peptide Sequences for CMTM7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the chemokine-like factor family.
  • Belongs to the chemokine-like factor family.
genes like me logo Genes that share domains with CMTM7: view

Function for CMTM7 Gene

Phenotypes From GWAS Catalog for CMTM7 Gene

Gene Ontology (GO) - Molecular Function for CMTM7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IEA --
genes like me logo Genes that share ontologies with CMTM7: view
genes like me logo Genes that share phenotypes with CMTM7: view

Animal Model Products

miRNA for CMTM7 Gene

miRTarBase miRNAs that target CMTM7

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CMTM7 Gene

Localization for CMTM7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CMTM7 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CMTM7 gene
Compartment Confidence
plasma membrane 3
extracellular 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CMTM7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IEA --
GO:0016020 membrane IDA,IEA 19946888
GO:0016021 integral component of membrane IEA,IBA --
genes like me logo Genes that share ontologies with CMTM7: view

Pathways & Interactions for CMTM7 Gene

SuperPathways for CMTM7 Gene

No Data Available

Interacting Proteins for CMTM7 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: ENSP00000335605 Q96FZ5-CKLF7_HUMAN for CMTM7 Gene via STRING UniProtKB IID

Gene Ontology (GO) - Biological Process for CMTM7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002337 B-1a B cell differentiation IEA --
GO:0006935 chemotaxis IEA --
genes like me logo Genes that share ontologies with CMTM7: view

No data available for Pathways by source and SIGNOR curated interactions for CMTM7 Gene

Drugs & Compounds for CMTM7 Gene

No Compound Related Data Available

Transcripts for CMTM7 Gene

Unigene Clusters for CMTM7 Gene

CKLF-like MARVEL transmembrane domain containing 7:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CMTM7 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c
SP1: - -
SP2: -
SP3: - - -
SP4: - - - -

Relevant External Links for CMTM7 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CMTM7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CMTM7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CMTM7 Gene

This gene is overexpressed in Whole Blood (x10.8).

Protein differential expression in normal tissues from HIPED for CMTM7 Gene

This gene is overexpressed in Plasma (50.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CMTM7 Gene

NURSA nuclear receptor signaling pathways regulating expression of CMTM7 Gene:


SOURCE GeneReport for Unigene cluster for CMTM7 Gene:


mRNA Expression by UniProt/SwissProt for CMTM7 Gene:

Tissue specificity: Highly expressed in leukocytes.

Evidence on tissue expression from TISSUES for CMTM7 Gene

  • Skin(2.4)
genes like me logo Genes that share expression patterns with CMTM7: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CMTM7 Gene

Orthologs for CMTM7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CMTM7 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CMTM7 33 34
  • 99.62 (n)
(Bos Taurus)
Mammalia CMTM7 33 34
  • 87.55 (n)
(Canis familiaris)
Mammalia CMTM7 33 34
  • 86.85 (n)
(Mus musculus)
Mammalia Cmtm7 33 16 34
  • 85.14 (n)
(Rattus norvegicus)
Mammalia Cmtm7 33
  • 84.47 (n)
(Ornithorhynchus anatinus)
Mammalia CMTM7 34
  • 76 (a)
(Monodelphis domestica)
Mammalia CMTM7 34
  • 68 (a)
(Gallus gallus)
Aves CMTM7 33 34
  • 66.48 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia cmtm7 33
  • 63.84 (n)
(Danio rerio)
Actinopterygii cmtm7 33 34
  • 56.38 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.146 34
  • 34 (a)
Species where no ortholog for CMTM7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CMTM7 Gene

Gene Tree for CMTM7 (if available)
Gene Tree for CMTM7 (if available)

Paralogs for CMTM7 Gene

(1) SIMAP similar genes for CMTM7 Gene using alignment to 4 proteins: Pseudogenes for CMTM7 Gene

genes like me logo Genes that share paralogs with CMTM7: view

No data available for Paralogs for CMTM7 Gene

Variants for CMTM7 Gene

Sequence variations from dbSNP and Humsavar for CMTM7 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000021787 -- 32,393,625(+) ATCTC(C/T)ACAAA intron-variant
rs1000053077 -- 32,393,313(+) AAAAA(A/T)ATCTG intron-variant
rs1000057839 -- 32,442,276(+) GAGGC(C/T)GAGGC intron-variant
rs1000115037 -- 32,418,964(+) TGAAC(C/T)TGCAT intron-variant
rs1000136696 -- 32,435,523(+) ATTAA(C/G)TAGGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CMTM7 Gene

Variant ID Type Subtype PubMed ID
esv3595775 CNV loss 21293372
nsv1003285 CNV gain 25217958
nsv1136714 CNV deletion 24896259
nsv518025 CNV gain 19592680
nsv522856 CNV gain 19592680
nsv834652 CNV loss 17160897
nsv954461 CNV duplication 24416366

Variation tolerance for CMTM7 Gene

Residual Variation Intolerance Score: 52.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.49; 10.71% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CMTM7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CMTM7 Gene

Disorders for CMTM7 Gene

Relevant External Links for CMTM7

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CMTM7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CMTM7 Gene

Publications for CMTM7 Gene

  1. Genomic variation associated with mortality among adults of European and African ancestry with heart failure: the cohorts for heart and aging research in genomic epidemiology consortium. (PMID: 20400778) Morrison AC … Smith NL (Circulation. Cardiovascular genetics 2010) 3 45 60
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  3. Identification of eight genes encoding chemokine-like factor superfamily members 1-8 (CKLFSF1-8) by in silico cloning and experimental validation. (PMID: 12782130) Han W … Ma D (Genomics 2003) 3 4 60
  4. CMTM7 knockdown increases tumorigenicity of human non-small cell lung cancer cells and EGFR-AKT signaling by reducing Rab5 activation. (PMID: 26528697) Liu B … Han W (Oncotarget 2015) 3 60
  5. A novel 3p22.3 gene CMTM7 represses oncogenic EGFR signaling and inhibits cancer cell growth. (PMID: 23893243) Li H … Han W (Oncogene 2014) 3 60

Products for CMTM7 Gene

Sources for CMTM7 Gene

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