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CMTM6 Gene

protein-coding   GIFtS: 48
GCID: GC03M032499

CKLF-Like MARVEL Transmembrane Domain Containing 6

(Previous names: chemokine-like factor super family 6, chemokine-like factor...)
(Previous symbol: CKLFSF6)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
CKLF-Like MARVEL Transmembrane Domain Containing 61 2     Chemokine-Like Factor Superfamily Member 62 3
CKLFSF61 2 3 5     PRO22192
Chemokine-Like Factor Super Family 61 2     CKLF-Like MARVEL Transmembrane Domain-Containing Protein 62
Chemokine-Like Factor Superfamily 61 2     

External Ids:    HGNC: 191771   Entrez Gene: 549182   Ensembl: ENSG000000913177   OMIM: 6078895   UniProtKB: Q9NX763   

Export aliases for CMTM6 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CMTM6 Gene:
This gene belongs to the chemokine-like factor gene superfamily, a novel family that is similar to the chemokine
and transmembrane 4 superfamilies. This gene is one of several chemokine-like factor genes located in a cluster
on chromosome 3. This gene is widely expressed in many tissues, but the exact function of the encoded protein is
unknown. (provided by RefSeq, Jul 2008)

GeneCards Summary for CMTM6 Gene:
CMTM6 (CKLF-like MARVEL transmembrane domain containing 6) is a protein-coding gene. GO annotations related to this gene include cytokine activity. An important paralog of this gene is CMTM4.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NC_018914.2  NT_022517.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the CMTM6 gene promoter:
         SRF   SRF (504 AA)   RelA   NF-kappaB   C/EBPalpha   FOXL1   RORalpha1   CP2   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCMTM6 promoter sequence
   Search Chromatin IP Primers for CMTM6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CMTM6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p22.3   Ensembl cytogenetic band:  3p22.3   HGNC cytogenetic band: 3p22.2

CMTM6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CMTM6 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M032499:  view genomic region     (about GC identifiers)

Start:
32,522,804 bp from pter      End:
32,544,900 bp from pter
Size:
22,097 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CKLF6_HUMAN, Q9NX76 (See protein sequence)
Recommended Name: CKLF-like MARVEL transmembrane domain-containing protein 6  
Size: 183 amino acids; 20419 Da
Secondary accessions: Q6IAC4

Explore the universe of human proteins at neXtProt for CMTM6: NX_Q9NX76

Explore proteomics data for CMTM6 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CMTM6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_060271.1  
    ENSEMBL proteins: 
     ENSP00000205636  

    CMTM6 Human Recombinant Protein Products:

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    Browse Proteins at Cloud-Clone Corp.

     
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    antibodies-online proteins for CMTM6 (2 products) 

     
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    antibodies-online antibodies for CMTM6 (17 products) 

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    Search eBioscience for ELISAs for CMTM6 
    antibodies-online kits for CMTM6 (23 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR008253 Marvel

    Graphical View of Domain Structure for InterPro Entry Q9NX76

    ProtoNet protein and cluster: Q9NX76

    1 Blocks protein domain: IPB008253 Marvel

    UniProtKB/Swiss-Prot: CKLF6_HUMAN, Q9NX76
    Similarity: Belongs to the chemokine-like factor family
    Similarity: Contains 1 MARVEL domain


    Find genes that share domains with CMTM6           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005125cytokine activity IEA--
         
    Find genes that share ontologies with CMTM6           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for CMTM6

    miRNA
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    miRTarBase miRNAs that target CMTM6:
    hsa-mir-26b-5p (MIRT029005), hsa-mir-192-5p (MIRT026194), hsa-mir-378a-3p (MIRT019660), hsa-mir-128-3p (MIRT021869), hsa-mir-92a-3p (MIRT049092), hsa-mir-215-5p (MIRT024261)

    Block miRNA regulation of human, mouse, rat CMTM6 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CMTM6 (see all 26):
    hsa-miR-140-5p hsa-let-7d hsa-let-7c hsa-miR-340 hsa-miR-3667-5p hsa-let-7g hsa-miR-9 hsa-let-7a
    SwitchGear 3'UTR luciferase reporter plasmidCMTM6 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CMTM6

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    Sino Biological Human cDNA Clone for CMTM6
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CMTM6

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CKLF6_HUMAN, Q9NX76: Membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular3
    plasma membrane3
    cytoskeleton1
    cytosol1
    nucleus1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IEA--
    GO:0016020membrane ----
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with CMTM6           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CMTM6
    Interactions:

        Search GeneGlobe Interaction Network for CMTM6

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    Selected Interacting proteins for CMTM6 (Q9NX762, 3 ENSP000002056364) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DNMT3BQ9UBC32, 3MINT-8252549 I2D: score=2 
    PPBPP027752, 3MINT-8252571 I2D: score=2 
    SUMO2P619562, 3MINT-8252582 I2D: score=2 
    XRCC6P129562, 3MINT-8252593 I2D: score=2 
    ATP13A2Q9NQ112, 3, ENSP000003272144MINT-8252538 I2D: score=2 STRING: ENSP00000327214
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    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006935chemotaxis IEA--

    Find genes that share ontologies with CMTM6           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CMTM6 (CKLF6)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CMTM6 gene: 
    NM_017801.2  

    Unigene Cluster for CMTM6:

    CKLF-like MARVEL transmembrane domain containing 6
    Hs.380627  [show with all ESTs]
    Unigene Representative Sequence: NM_017801
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000205636(uc003cfa.1) ENST00000478886 ENST00000495177
    miRNA
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    Block miRNA regulation of human, mouse, rat CMTM6 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CMTM6 (see all 26):
    hsa-miR-140-5p hsa-let-7d hsa-let-7c hsa-miR-340 hsa-miR-3667-5p hsa-let-7g hsa-miR-9 hsa-let-7a
    SwitchGear 3'UTR luciferase reporter plasmidCMTM6 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CMTM6
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    GenScript: all cDNA clones in your preferred vector: CMTM6 (NM_017801)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CMTM6
    Primer
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    OriGene qPCR primer pairs and template standards for CMTM6
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      QuantiTect SYBR Green Assays in human, mouse, rat CMTM6
      QuantiFast Probe-based Assays in human, mouse, rat CMTM6

    Additional mRNA sequence: 

    AK000403.1 AK172793.1 BC002797.2 BC009187.2 BC027472.1 CR457231.1 

    14 DOTS entries:

    DT.100794687  DT.80101456  DT.92447804  DT.120884834  DT.92447802  DT.100794689  DT.120884865  DT.95168228 
    DT.95168231  DT.100711974  DT.120884841  DT.120884891  DT.92397630  DT.95168235 

    Selected AceView cDNA sequences (see all 542):

    AI245855 AA811152 BM721042 BE514833 AI884604 BC002797 BX486307 AI379173 
    AW613910 BI819001 BQ272295 AI568524 BQ008107 BP380167 CA944908 AL705312 
    BM927081 AA748810 CD743159 N47216 BI061620 AA935890 AI800521 AI950185 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CMTM6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCTGCTGCT
    CMTM6 Expression
    About this image

    CMTM6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CMTM6 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.380627

    UniProtKB/Swiss-Prot: CKLF6_HUMAN, Q9NX76
    Tissue specificity: Expressed in the leukocytes, placenta and testis

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CMTM6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CMTM6 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cmtm61 , 5 CKLF-like MARVEL transmembrane domain containing 61, 5 77.96(n)1
    83.06(a)1
      9 (65.06 cM)5
    672131  NM_026036.31  NP_080312.11 
     1147312035 
    chicken
    (Gallus gallus)
    Aves CMTM61 CKLF-like MARVEL transmembrane domain containing 6 56.93(n)
    47.75(a)
      420667  XM_418766.4  XP_418766.3 
    lizard
    (Anolis carolinensis)
    Reptilia CMTM66
    CKLF-like MARVEL transmembrane domain containing 6...
    77(a)
    1 ↔ 1
    1(193544284-193544442)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia cmtm61 CKLF-like MARVEL transmembrane domain containing 6 49.52(n)
    41.71(a)
      548405  NM_001039741.1  NP_001034830.1 
    zebrafish
    (Danio rerio)
    Actinopterygii cmtm61 CKLF-like MARVEL transmembrane domain containing 6 46.29(n)
    38.86(a)
      368348  NM_001044756.2  NP_001038221.1 


    ENSEMBL Gene Tree for CMTM6 (if available)
    TreeFam Gene Tree for CMTM6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CMTM6 gene
    CMTM42  
    1 SIMAP similar gene for CMTM6 using alignment to 1 protein entry:     CKLF6_HUMAN:
    CMTM4

    Find genes that share paralogs with CMTM6           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for CMTM6
    PGOHUM00000244200 PGOHUM00000259821


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CMTM6 (see all 458)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs730687631,2
    C,F--32522388(+) ATTTCG/ACAAAC 1 -- ds50012Minor allele frequency- A:0.07NA 122
    rs1501372021,2
    --32522507(+) GTTAGC/TCACAT 1 -- ds50010--------
    rs1387757971,2
    --32522569(+) ATTTGA/TAAGTC 1 -- ds50010--------
    rs1414416511,2
    C--32522729(+) TGCAG-/CCCCC 
            
    CCAAC
    1 -- ds50010--------
    rs1449764271,2
    C--32522861(+) AGAGA-/TTAAAA 1 -- ut310--------
    rs1824887001,2
    --32523152(+) TTGAAC/TTTATT 1 -- ut310--------
    rs170295971,2
    C,F,H--32523287(+) AACATA/CCTATC 1 -- ut3120Minor allele frequency- C:0.06NA NS EA WA 2308
    rs1152332521,2
    C,F--32523315(+) ATTAAG/ATGACC 1 -- ut311Minor allele frequency- A:0.01WA 118
    rs1418502631,2
    C--32523429(+) TGAGAA/CTGTAT 1 -- ut310--------
    rs1157253051,2
    C,F--32523459(+) CCAATA/GCATGG 1 -- ut311Minor allele frequency- G:0.02WA 118

    HapMap Linkage Disequilibrium report for CMTM6 (32522804 - 32544900 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for CMTM6:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv834652CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CMTM6
    DNA2.0 Custom Variant and Variant Library Synthesis for CMTM6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607889    OMIM disorders: --


    Find genes that share disorders with CMTM6           About GenesLikeMe

    Human Genome Epidemiology (HuGE) Navigator: CMTM6 (1 document)

    Export disorders for CMTM6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CMTM6 gene, integrated from 10 sources (see all 13):
    (articles sorted by number of sources associating them with CMTM6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. Identification of eight genes encoding chemokine-like factor superfamily members 1-8 (CKLFSF1-8) by in silico cloning and experimental validation. (PubMed id 12782130)1, 2 Han W.... Ma D. (Genomics 2003)
    4. Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)1 Oshikawa K....Nakayama K.I. (J. Proteome Res. 2012)
    5. Comparative large scale characterization of plant versus mammal proteins reveals similar and idiosyncratic N-I+-acetylation features. (PubMed id 22223895)2 Bienvenut W.V....Giglione C. (amp 2012)
    6. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    7. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    8. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    9. A directed protein interaction network for investigating intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (Sci Signal 2011)
    10. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (Sci. Signal. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 54918 HGNC: 19177 AceView: CKLFSF6 Ensembl:ENSG00000091317 euGenes: HUgn54918
    ECgene: CMTM6 H-InvDB: CMTM6

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CMTM6 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CMTM6 gene:
    Search GeneIP for patents involving CMTM6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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