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Aliases for CMTM6 Gene

Aliases for CMTM6 Gene

  • CKLF-Like MARVEL Transmembrane Domain Containing 6 2 3
  • CKLFSF6 3 4 6
  • Chemokine-Like Factor Superfamily Member 6 3 4
  • Chemokine-Like Factor Super Family 6 2 3
  • Chemokine-Like Factor Superfamily 6 2 3
  • CKLF-Like MARVEL Transmembrane Domain-Containing Protein 6 3
  • PRO2219 3

External Ids for CMTM6 Gene

Previous HGNC Symbols for CMTM6 Gene


Summaries for CMTM6 Gene

Entrez Gene Summary for CMTM6 Gene

  • This gene belongs to the chemokine-like factor gene superfamily, a novel family that is similar to the chemokine and transmembrane 4 superfamilies. This gene is one of several chemokine-like factor genes located in a cluster on chromosome 3. This gene is widely expressed in many tissues, but the exact function of the encoded protein is unknown. [provided by RefSeq, Jul 2008]

GeneCards Summary for CMTM6 Gene

CMTM6 (CKLF-Like MARVEL Transmembrane Domain Containing 6) is a Protein Coding gene. GO annotations related to this gene include cytokine activity. An important paralog of this gene is CMTM4.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CMTM6 Gene

Genomics for CMTM6 Gene

Regulatory Elements for CMTM6 Gene

Genomic Location for CMTM6 Gene

32,481,312 bp from pter
32,503,408 bp from pter
22,097 bases
Minus strand

Genomic View for CMTM6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CMTM6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CMTM6 Gene

Proteins for CMTM6 Gene

  • Protein details for CMTM6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    CKLF-like MARVEL transmembrane domain-containing protein 6
    Protein Accession:
    Secondary Accessions:
    • Q6IAC4

    Protein attributes for CMTM6 Gene

    183 amino acids
    Molecular mass:
    20419 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CMTM6 Gene

Proteomics data for CMTM6 Gene at MOPED

Post-translational modifications for CMTM6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CMTM6 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for CMTM6 Gene

Domains for CMTM6 Gene

Gene Families for CMTM6 Gene

Protein Domains for CMTM6 Gene


Suggested Antigen Peptide Sequences for CMTM6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 MARVEL domain.
  • Belongs to the chemokine-like factor family.
  • Contains 1 MARVEL domain.
  • Belongs to the chemokine-like factor family.
genes like me logo Genes that share domains with CMTM6: view

Function for CMTM6 Gene

Gene Ontology (GO) - Molecular Function for CMTM6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IEA --
genes like me logo Genes that share ontologies with CMTM6: view

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CMTM6

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targets and HOMER Transcription for CMTM6 Gene

Localization for CMTM6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CMTM6 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for CMTM6 Gene COMPARTMENTS Subcellular localization image for CMTM6 gene
Compartment Confidence
extracellular 3
plasma membrane 3
cytoskeleton 1
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for CMTM6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IEA --
GO:0016020 membrane IDA 19946888
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with CMTM6: view

Pathways for CMTM6 Gene

SuperPathways for CMTM6 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CMTM6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006935 chemotaxis IEA --
genes like me logo Genes that share ontologies with CMTM6: view

No data available for Pathways by source for CMTM6 Gene

Transcripts for CMTM6 Gene

mRNA/cDNA for CMTM6 Gene

Unigene Clusters for CMTM6 Gene

CKLF-like MARVEL transmembrane domain containing 6:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CMTM6

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CMTM6 Gene

No ASD Table

Relevant External Links for CMTM6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CMTM6 Gene

mRNA expression in normal human tissues for CMTM6 Gene

mRNA differential expression in normal tissues according to GTEx for CMTM6 Gene

This gene is overexpressed in Whole Blood (5.9).

Protein differential expression in normal tissues for CMTM6 Gene

This gene is overexpressed in Monocytes (26.7), Bone (9.2), and Peripheral blood mononuclear cells (9.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CMTM6 Gene

SOURCE GeneReport for Unigene cluster for CMTM6 Gene Hs.380627

mRNA Expression by UniProt/SwissProt for CMTM6 Gene

Tissue specificity: Expressed in the leukocytes, placenta and testis.
genes like me logo Genes that share expressions with CMTM6: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Expression partners for CMTM6 Gene

Orthologs for CMTM6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CMTM6 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CMTM6 35
  • 75.46 (n)
  • 70.88 (a)
CMTM6 36
  • 71 (a)
(Canis familiaris)
Mammalia CMTM6 35
  • 81.14 (n)
  • 79.12 (a)
CMTM6 36
  • 79 (a)
(Mus musculus)
Mammalia Cmtm6 35
  • 77.96 (n)
  • 83.06 (a)
Cmtm6 16
Cmtm6 36
  • 83 (a)
(Pan troglodytes)
Mammalia CMTM6 35
  • 99.64 (n)
  • 98.91 (a)
CMTM6 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Cmtm6 35
  • 79.42 (n)
  • 84.15 (a)
(Monodelphis domestica)
Mammalia CMTM6 36
  • 54 (a)
(Ornithorhynchus anatinus)
Mammalia CMTM6 36
  • 73 (a)
(Gallus gallus)
Aves CMTM6 35
  • 56.93 (n)
  • 47.75 (a)
CMTM6 36
  • 39 (a)
(Anolis carolinensis)
Reptilia CMTM6 36
  • 77 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cmtm6 35
  • 49.52 (n)
  • 41.71 (a)
(Danio rerio)
Actinopterygii cmtm6 35
  • 46.29 (n)
  • 38.86 (a)
cmtm6 36
  • 34 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2454 36
  • 13 (a)
Species with no ortholog for CMTM6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CMTM6 Gene

Gene Tree for CMTM6 (if available)
Gene Tree for CMTM6 (if available)

Paralogs for CMTM6 Gene

Paralogs for CMTM6 Gene

(1) SIMAP similar genes for CMTM6 Gene using alignment to 1 proteins: Pseudogenes for CMTM6 Gene

genes like me logo Genes that share paralogs with CMTM6: view

Variants for CMTM6 Gene

Sequence variations from dbSNP and Humsavar for CMTM6 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs4796 -- 32,482,285(-) GGCCC(A/G)ACATA utr-variant-3-prime
rs164207 -- 32,504,199(-) GAAGG(G/T)TAGTT upstream-variant-2KB
rs164208 -- 32,503,449(-) ctttc(A/G)tgaaa upstream-variant-2KB
rs164209 -- 32,503,270(-) ctcct(C/T)catct upstream-variant-2KB
rs164210 -- 32,492,292(-) TGCTC(C/T)CTCAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CMTM6 Gene

Variant ID Type Subtype PubMed ID
nsv834652 CNV Loss 17160897

Relevant External Links for CMTM6 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CMTM6 Gene

Disorders for CMTM6 Gene

Relevant External Links for CMTM6

Human Genome Epidemiology (HuGE) Navigator

No disorders were found for CMTM6 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for CMTM6 Gene

Publications for CMTM6 Gene

  1. Identification of eight genes encoding chemokine-like factor superfamily members 1-8 (CKLFSF1-8) by in silico cloning and experimental validation. (PMID: 12782130) Han W. … Ma D. (Genomics 2003) 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3
  5. Defining the membrane proteome of NK cells. (PMID: 19946888) Ghosh D. … Wilkins J.A. (J Mass Spectrom 2010) 3

Products for CMTM6 Gene

Sources for CMTM6 Gene

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