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Aliases for CMTM5 Gene

Aliases for CMTM5 Gene

  • CKLF Like MARVEL Transmembrane Domain Containing 5 2 3
  • CKLF-Like MARVEL Transmembrane Domain Containing 5 2 3 5
  • Chemokine-Like Factor Superfamily Member 5 3 4
  • Chemokine-Like Factor Super Family 5 2 3
  • CKLFSF5 3 4
  • Chemokine-Like Factor Superfamily 5 2

External Ids for CMTM5 Gene

Previous HGNC Symbols for CMTM5 Gene

  • CKLFSF5

Previous GeneCards Identifiers for CMTM5 Gene

  • GC14P022916
  • GC14P023846
  • GC14P003962
  • GC14P023468
  • GC14P023549

Summaries for CMTM5 Gene

Entrez Gene Summary for CMTM5 Gene

  • This gene encodes a member of the chemokine-like factor superfamily. This family of genes encodes multi-pass membrane proteins that are similar to both the chemokine and the transmembrane 4 superfamilies of signaling molecules. The encoded protein may exhibit tumor suppressor activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

GeneCards Summary for CMTM5 Gene

CMTM5 (CKLF Like MARVEL Transmembrane Domain Containing 5) is a Protein Coding gene. GO annotations related to this gene include cytokine activity. An important paralog of this gene is PLP2.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CMTM5 Gene

Genomics for CMTM5 Gene

Regulatory Elements for CMTM5 Gene

Genomic Location for CMTM5 Gene

Chromosome:
14
Start:
23,376,808 bp from pter
End:
23,379,772 bp from pter
Size:
2,965 bases
Orientation:
Plus strand

Genomic View for CMTM5 Gene

Genes around CMTM5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CMTM5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CMTM5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CMTM5 Gene

Proteins for CMTM5 Gene

  • Protein details for CMTM5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96DZ9-CKLF5_HUMAN
    Recommended name:
    CKLF-like MARVEL transmembrane domain-containing protein 5
    Protein Accession:
    Q96DZ9
    Secondary Accessions:
    • E9PH91
    • Q5PY48

    Protein attributes for CMTM5 Gene

    Size:
    223 amino acids
    Molecular mass:
    24653 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CMTM5 Gene

neXtProt entry for CMTM5 Gene

Proteomics data for CMTM5 Gene at MOPED

Post-translational modifications for CMTM5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for CMTM5 Gene

Domains & Families for CMTM5 Gene

Gene Families for CMTM5 Gene

Protein Domains for CMTM5 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q96DZ9

UniProtKB/Swiss-Prot:

CKLF5_HUMAN :
  • Contains 1 MARVEL domain.
  • Belongs to the chemokine-like factor family.
Domain:
  • Contains 1 MARVEL domain.
Family:
  • Belongs to the chemokine-like factor family.
genes like me logo Genes that share domains with CMTM5: view

Function for CMTM5 Gene

Gene Ontology (GO) - Molecular Function for CMTM5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21516116
genes like me logo Genes that share ontologies with CMTM5: view
genes like me logo Genes that share phenotypes with CMTM5: view

Animal Models for CMTM5 Gene

MGI Knock Outs for CMTM5:

Animal Model Products

CRISPR Products

miRNA for CMTM5 Gene

miRTarBase miRNAs that target CMTM5

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CMTM5 Gene

Localization for CMTM5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CMTM5 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CMTM5 Gene COMPARTMENTS Subcellular localization image for CMTM5 gene
Compartment Confidence
extracellular 3
plasma membrane 3
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for CMTM5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CMTM5: view

Pathways & Interactions for CMTM5 Gene

SuperPathways for CMTM5 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CMTM5 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CMTM5 Gene

Drugs & Compounds for CMTM5 Gene

No Compound Related Data Available

Transcripts for CMTM5 Gene

Unigene Clusters for CMTM5 Gene

CKLF-like MARVEL transmembrane domain containing 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CMTM5 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3 ^ 4 ^ 5 ^ 6
SP1:
SP2: - - - -
SP3: -
SP4: - -
SP5: -
SP6: - - -
SP7: - -

Relevant External Links for CMTM5 Gene

GeneLoc Exon Structure for
CMTM5
ECgene alternative splicing isoforms for
CMTM5

Expression for CMTM5 Gene

mRNA expression in normal human tissues for CMTM5 Gene

mRNA differential expression in normal tissues according to GTEx for CMTM5 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x12.9) and Brain - Substantia nigra (x6.3).

Protein differential expression in normal tissues from HIPED for CMTM5 Gene

This gene is overexpressed in Platelet (40.1), Peripheral blood mononuclear cells (12.9), and Frontal cortex (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CMTM5 Gene



SOURCE GeneReport for Unigene cluster for CMTM5 Gene Hs.99272

mRNA Expression by UniProt/SwissProt for CMTM5 Gene

Q96DZ9-CKLF5_HUMAN
Tissue specificity: Highly expressed in the brain.
genes like me logo Genes that share expression patterns with CMTM5: view

Protein tissue co-expression partners for CMTM5 Gene

Primer Products

In Situ Assay Products

Orthologs for CMTM5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CMTM5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CMTM5 36
  • 70 (a)
OneToOne
CMTM5 35
  • 99.36 (n)
  • 99.36 (a)
cow
(Bos Taurus)
Mammalia CMTM5 35
  • 90.38 (n)
  • 86.54 (a)
CMTM5 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CMTM5 36
  • 88 (a)
OneToOne
CMTM5 35
  • 90.6 (n)
  • 87.82 (a)
mouse
(Mus musculus)
Mammalia Cmtm5 16
Cmtm5 36
  • 84 (a)
OneToOne
Cmtm5 35
  • 86.97 (n)
  • 83.97 (a)
oppossum
(Monodelphis domestica)
Mammalia CMTM5 36
  • 46 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cmtm5 35
  • 86.75 (n)
  • 83.97 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 29 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia CMTM5 36
  • 43 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cmtm5 35
  • 58.52 (n)
  • 49.62 (a)
zebrafish
(Danio rerio)
Actinopterygii zgc:136605 36
  • 22 (a)
ManyToMany
Species with no ortholog for CMTM5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CMTM5 Gene

ENSEMBL:
Gene Tree for CMTM5 (if available)
TreeFam:
Gene Tree for CMTM5 (if available)

Paralogs for CMTM5 Gene

Paralogs for CMTM5 Gene

(1) SIMAP similar genes for CMTM5 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CMTM5: view

Variants for CMTM5 Gene

Sequence variations from dbSNP and Humsavar for CMTM5 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs723840 -- 23,379,102(+) CGGGA(C/T)GGAGC intron-variant, reference, synonymous-codon
rs11552255 -- 23,377,312(+) AGCTC(A/C)AGGGC reference, missense
rs56182801 -- 23,377,697(+) CAGCA(C/G)GTCCA intron-variant
rs61977667 -- 23,377,725(+) AAAGG(A/G)CAGAC intron-variant
rs61237612 -- 23,378,444(+) TTCCT(C/G)TTCCT intron-variant, reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for CMTM5 Gene

Variant ID Type Subtype PubMed ID
nsv901493 CNV Loss 21882294

Variation tolerance for CMTM5 Gene

Residual Variation Intolerance Score: 67.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.56; 44.51% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CMTM5 Gene

HapMap Linkage Disequilibrium report
CMTM5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CMTM5 Gene

Disorders for CMTM5 Gene

Relevant External Links for CMTM5

Human Genome Epidemiology (HuGE) Navigator
CMTM5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CMTM5

No disorders were found for CMTM5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CMTM5 Gene

Publications for CMTM5 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. [Abnormally lower expression of cmtm5 gene in bone marrow cells from patients with multiple myeloma]. (PMID: 20416169) Niu J.H. … Ruan G.R. (Zhongguo Shi Yan Xue Ye Xue Za Zhi 2010) 3 23
  3. CMTM5 exhibits tumor suppressor activities and is frequently silenced by methylation in carcinoma cell lines. (PMID: 17908965) Shao L. … Tao Q. (Clin. Cancer Res. 2007) 3 23
  4. CMTM5 exhibits tumor suppressor activity through promoter methylation in oral squamous cell carcinoma. (PMID: 24721428) Zhang H. … Li T. (Biochem. Biophys. Res. Commun. 2014) 3
  5. Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism. (PMID: 24722188) Corominas R. … Iakoucheva L.M. (Nat. Commun. 2014) 3

Products for CMTM5 Gene

Sources for CMTM5 Gene

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