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Aliases for CMTM5 Gene

Aliases for CMTM5 Gene

  • CKLF-Like MARVEL Transmembrane Domain Containing 5 2 3
  • CKLFSF5 3 4 6
  • Chemokine-Like Factor Superfamily Member 5 3 4
  • Chemokine-Like Factor Super Family 5 2 3
  • CKLF-Like MARVEL Transmembrane Domain-Containing Protein 5 3
  • Chemokine-Like Factor Superfamily 5 2

External Ids for CMTM5 Gene

Previous HGNC Symbols for CMTM5 Gene


Previous GeneCards Identifiers for CMTM5 Gene

  • GC14P022916
  • GC14P023846
  • GC14P003962

Summaries for CMTM5 Gene

Entrez Gene Summary for CMTM5 Gene

  • This gene encodes a member of the chemokine-like factor superfamily. This family of genes encodes multi-pass membrane proteins that are similar to both the chemokine and the transmembrane 4 superfamilies of signaling molecules. The encoded protein may exhibit tumor suppressor activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

GeneCards Summary for CMTM5 Gene

CMTM5 (CKLF-Like MARVEL Transmembrane Domain Containing 5) is a Protein Coding gene. Diseases associated with CMTM5 include ovarian cystadenoma. GO annotations related to this gene include cytokine activity. An important paralog of this gene is PLP2.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CMTM5 Gene

Genomics for CMTM5 Gene

Regulatory Elements for CMTM5 Gene

Genomic Location for CMTM5 Gene

23,376,808 bp from pter
23,379,772 bp from pter
2,965 bases
Plus strand

Genomic View for CMTM5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CMTM5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CMTM5 Gene

Proteins for CMTM5 Gene

  • Protein details for CMTM5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    CKLF-like MARVEL transmembrane domain-containing protein 5
    Protein Accession:
    Secondary Accessions:
    • E9PH91
    • Q5PY48

    Protein attributes for CMTM5 Gene

    223 amino acids
    Molecular mass:
    24653 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CMTM5 Gene

neXtProt entry for CMTM5 Gene

Proteomics data for CMTM5 Gene at MOPED

Post-translational modifications for CMTM5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for CMTM5 Gene

Domains for CMTM5 Gene

Gene Families for CMTM5 Gene

Protein Domains for CMTM5 Gene


Graphical View of Domain Structure for InterPro Entry



  • Contains 1 MARVEL domain.
  • Belongs to the chemokine-like factor family.
  • Contains 1 MARVEL domain.
  • Belongs to the chemokine-like factor family.
genes like me logo Genes that share domains with CMTM5: view

Function for CMTM5 Gene

Gene Ontology (GO) - Molecular Function for CMTM5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IEA --
GO:0005515 protein binding IPI 21516116
genes like me logo Genes that share ontologies with CMTM5: view

Phenotypes for CMTM5 Gene

GenomeRNAi human phenotypes for CMTM5:
genes like me logo Genes that share phenotypes with CMTM5: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CMTM5

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CMTM5 Gene

Localization for CMTM5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CMTM5 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for CMTM5 Gene COMPARTMENTS Subcellular localization image for CMTM5 gene
Compartment Confidence
extracellular 3
plasma membrane 3
golgi apparatus 1
lysosome 1

Gene Ontology (GO) - Cellular Components for CMTM5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IEA --
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CMTM5: view

Pathways for CMTM5 Gene

SuperPathways for CMTM5 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CMTM5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006935 chemotaxis IEA --
GO:0045662 negative regulation of myoblast differentiation IEA --
genes like me logo Genes that share ontologies with CMTM5: view

No data available for Pathways by source for CMTM5 Gene

Transcripts for CMTM5 Gene

Unigene Clusters for CMTM5 Gene

CKLF-like MARVEL transmembrane domain containing 5:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CMTM5

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CMTM5 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3 ^ 4 ^ 5 ^ 6
SP2: - - - -
SP3: -
SP4: - -
SP5: -
SP6: - - -
SP7: - -

Relevant External Links for CMTM5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CMTM5 Gene

mRNA expression in normal human tissues for CMTM5 Gene

mRNA differential expression in normal tissues according to GTEx for CMTM5 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (12.9) and Brain - Substantia nigra (6.3).

Protein differential expression in normal tissues for CMTM5 Gene

This gene is overexpressed in Platelet (40.1), Peripheral blood mononuclear cells (12.9), and Frontal cortex (6.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CMTM5 Gene

SOURCE GeneReport for Unigene cluster for CMTM5 Gene Hs.99272

mRNA Expression by UniProt/SwissProt for CMTM5 Gene

Tissue specificity: Highly expressed in the brain.
genes like me logo Genes that share expressions with CMTM5: view

Expression partners for CMTM5 Gene

* - Elite partner

Primer Products

In Situ Assay Products

Orthologs for CMTM5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CMTM5 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CMTM5 35
  • 90.38 (n)
  • 86.54 (a)
CMTM5 36
  • 87 (a)
(Canis familiaris)
Mammalia CMTM5 35
  • 90.6 (n)
  • 87.82 (a)
CMTM5 36
  • 88 (a)
(Mus musculus)
Mammalia Cmtm5 35
  • 86.97 (n)
  • 83.97 (a)
Cmtm5 16
Cmtm5 36
  • 84 (a)
(Pan troglodytes)
Mammalia CMTM5 35
  • 99.36 (n)
  • 99.36 (a)
CMTM5 36
  • 70 (a)
(Rattus norvegicus)
Mammalia Cmtm5 35
  • 86.75 (n)
  • 83.97 (a)
(Monodelphis domestica)
Mammalia CMTM5 36
  • 46 (a)
(Gallus gallus)
Aves -- 36
  • 29 (a)
(Anolis carolinensis)
Reptilia CMTM5 36
  • 43 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cmtm5 35
  • 58.52 (n)
  • 49.62 (a)
(Danio rerio)
Actinopterygii zgc:136605 36
  • 22 (a)
Species with no ortholog for CMTM5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CMTM5 Gene

Gene Tree for CMTM5 (if available)
Gene Tree for CMTM5 (if available)

Paralogs for CMTM5 Gene

Paralogs for CMTM5 Gene

(1) SIMAP similar genes for CMTM5 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CMTM5: view

Variants for CMTM5 Gene

Sequence variations from dbSNP and Humsavar for CMTM5 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs723840 -- 23,379,102(+) CGGGA(C/T)GGAGC intron-variant, reference, synonymous-codon
rs742873 -- 23,380,092(-) CGAGC(C/G)CCTGG downstream-variant-500B
rs1076755 -- 23,378,372(-) AAGCA(A/G)ATGAA reference, synonymous-codon, intron-variant
rs7148331 -- 23,377,468(+) CAGTA(G/T)CCTCC intron-variant
rs7150284 -- 23,377,481(+) CCCCA(A/G)GCCCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CMTM5 Gene

Variant ID Type Subtype PubMed ID
nsv901493 CNV Loss 21882294

Relevant External Links for CMTM5 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CMTM5 Gene

Disorders for CMTM5 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for CMTM5 Gene in MalaCards »

(1) Disease for CMTM5 Gene

(1) University of Copenhagen DISEASES for CMTM5 Gene

Relevant External Links for CMTM5

Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with CMTM5: view

No data available for OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships and Genatlas for CMTM5 Gene

Publications for CMTM5 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. CMTM5 exhibits tumor suppressor activities and is frequently silenced by methylation in carcinoma cell lines. (PMID: 17908965) Shao L. … Tao Q. (Clin. Cancer Res. 2007) 3 23
  3. Identification of eight genes encoding chemokine-like factor superfamily members 1-8 (CKLFSF1-8) by in silico cloning and experimental validation. (PMID: 12782130) Han W. … Ma D. (Genomics 2003) 3 4
  4. [Abnormally lower expression of cmtm5 gene in bone marrow cells from patients with multiple myeloma]. (PMID: 20416169) Niu J.H. … Ruan G.R. (Zhongguo Shi Yan Xue Ye Xue Za Zhi 2010) 3 23
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3

Products for CMTM5 Gene

Sources for CMTM5 Gene

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