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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CMTM5 Gene

protein-coding GIFtS: 51
GCID: GC14P023846

CKLF-like MARVEL transmembrane domain containing 5

(Previous names: chemokine-like factor super family 5, chemokine-like factor...)
(Previous symbol: CKLFSF5)

Explore 14 diseases affiliated with
CMTM5 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
CKLF-Like MARVEL Transmembrane Domain Containing 5¹ ²		FLJ37521¹
CKLFSF5¹ ² ³		Chemokine-Like Factor Superfamily 5¹
Chemokine-Like Factor Super Family 5¹ ²		CKLF-Like MARVEL Transmembrane Domain-Containing Protein 5²
Chemokine-Like Factor Superfamily Member 5² ³

External Ids:	HGNC: 19176¹	Entrez Gene: 116173²	Ensembl: ENSG00000166091⁷	OMIM: 607888⁵	UniProtKB: Q96DZ9³

Export aliases for CMTM5 gene to outside databases

Previous GC identifers: GC14P022916 GC14P003962

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CMTM5:

This gene belongs to the chemokine-like factor gene superfamily. This family of genes encodes multi-pass membrane

proteins that are similar to both the chemokine and the transmembrane 4 superfamilies of signaling molecules.

Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized.

(provided by RefSeq, Jul 2008)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000014.8 NC_018925.1 NT_026437.12

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CMTM5 gene promoter:
GR p53 GR-beta GR-alpha
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CMTM5 promoter sequence

Search SABiosciences Chromatin IP Primers for CMTM5

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CMTM5

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q11.2 Ensembl cytogenetic band: 14q11.2 HGNC cytogenetic band: 14q11.2

CMTM5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CMTM5 gene location

GeneLoc information about chromosome 14 GeneLoc Exon Structure

GeneLoc location for GC14P023846: view genomic region (about GC identifiers)

Start:	23,846,017 bp from pter	End:	23,848,981 bp from pter
Size:	2,965 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CKLF5_HUMAN, Q96DZ9 (See protein sequence)

Recommended Name: CKLF-like MARVEL transmembrane domain-containing protein 5

Size: 223 amino acids; 24653 Da

Subcellular location: Membrane; Multi-pass membrane protein

Alternative splicing: 5 isoforms: Q96DZ9-1 Q96DZ9-2 Q96DZ9-3 Q96DZ9-4 Q96DZ9-5

Explore the universe of human proteins at neXtProt for CMTM5: NX_Q96DZ9

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q96DZ9

CMTM5 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001032365.1 NP_612469.1

ENSEMBL proteins:

ENSP00000352270 ENSP00000344819 ENSP00000344160 ENSP00000380404 ENSP00000451514

ENSP00000372259

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Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005615	extracellular space	IEA	--
GO:0016020	membrane	--	--
GO:0016021	integral to membrane	IEA	--

CMTM5 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CMTM5 for domains About GeneDecksing

1 InterPro domain/family:

IPR008253 Marvel

Graphical View of Domain Structure for InterPro Entry Q96DZ9

ProtoNet protein and cluster: Q96DZ9

1 Blocks protein family: IPB008253 Marvel

UniProtKB/Swiss-Prot: CKLF5_HUMAN, Q96DZ9

Similarity: Belongs to the chemokine-like factor family

Similarity: Contains 1 MARVEL domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

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Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005125	cytokine activity	IEA	--

CMTM5 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for CMTM5:

Increased gamma-H2AX phosphory

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for CMTM5

5/7 Interacting proteins for CMTM5 (Q96DZ9³) via UniProtKB, MINT, STRING, and/or I2D (see all 7)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ACSF2	Q96CM8³	I2D: score=1
CREB3	O43889³	I2D: score=1
FERMT2	Q96AC1³	I2D: score=1
GAD1	Q99259³	I2D: score=1
HNRNPK	P61978³	I2D: score=1

About this table

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006935	chemotaxis	IEA	--

CMTM5 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
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About This Section

REFSEQ mRNAs for CMTM5 gene (3 alternative transcripts):

NM_001037288.1 NM_138460.2 NM_181618.1

Unigene Cluster for CMTM5:

CKLF-like MARVEL transmembrane domain containing 5

Hs.99272 [show with all ESTs]

Unigene Representative Sequence: BM926366

8 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000359320(uc001wjs.3 uc001wjt.3 uc010akm.3 uc010akn.3 uc001wju.3 uc010ako.3)

ENST00000339180 ENST00000342473 ENST00000397227 ENST00000553750 ENST00000555731

ENST00000382809 ENST00000555487

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Additional cDNA sequence:

AF479262.2 AF527413.1 AF527414.1 AF527948.2 AF527949.1 AK289886.1 AY820135.1 BC013109.1

6 DOTS entries:

DT.40119681 DT.95253995 DT.101983468 DT.101983469 DT.101983466 DT.91732796

24/46 AceView cDNA sequences (see all 46):

AW294278 AW291570 NM_138460 AI553750 AW296102 AI147740 AF527949 BM726492

AI471151 NM_181618 AI421902 BM929839 AF479262 AF527948 BI545079 BM684274

BI754958 AK094840 BM807689 BI755570 BI669794 BM925565 BC029729 AF527413

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for CMTM5 (see all 7) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	·	1e	·	1f	^	2	^	3	^	4	^	5	^	6
SP1:
SP2:			-		-		-								-
SP3:															-
SP4:													-		-
SP5:															-

ECgene alternative splicing isoforms for CMTM5

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CMTM5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAGCTCTGGC

About this image

CMTM5 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Bone

Zeugopod Epiphyseal End

Bone

Zeugopod Growth Plate

Bone

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See CMTM5 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CMTM5

SOURCE GeneReport for Unigene cluster: Hs.99272

UniProtKB/Swiss-Prot: CKLF5_HUMAN, Q96DZ9

Tissue specificity: Highly expressed in the brain

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of human and mouse.

Orthologs for CMTM5 gene from 1/5 species (see all 5) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Cmtm5^{1 , 5}	CKLF-like MARVEL transmembrane domain containing 5^{1, 5}	86.97(n)¹ 83.97(a)¹		14 (28.00 cM)⁵ 67272¹ NM_026066.2¹ NP_080342.1¹ 54936470⁵

ENSEMBL Gene Tree for CMTM5 (if available)
TreeFam Gene Tree for CMTM5 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CMTM5 gene

PLP2² CMTM3²

1 SIMAP similar gene for CMTM5 using alignment to 4 protein entries: CKLF5_HUMAN (see all proteins):

CMTM3

CMTM5 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 14 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs143905849^1,2		--	23846128(+)	`ACCTCC/TTCCTC`	2	--	ut5¹		0	--	--	--	--
rs186074535^1,2		--	23846207(+)	`CTCTGC/TCCCTC`	2	--	ut5¹		0	--	--	--	--
rs11465526^1,2	C,F,	--	23846298(+)	`CCCCAG/TCGCCT`	2	--	ut5¹ ese³		5		NA EU WA	330
rs147200167^1,2		--	23846316(+)	`CTCCCA/GGGGCC`	2	--	ut5¹		0	--	--	--	--
rs190597223^1,2		--	23846376(+)	`TGCTCC/TTGTCT`	2	--	ut5¹		0	--	--	--	--
rs138828400^1,2	C,F,	--	23846482(+)	`ATCGCC/TGGGAC`	4	R W	mis¹		1		NA	4552
rs200320289^1,2		--	23846483(+)	`TCGCCA/GGGACC`	4	Q R	mis¹		0	--	--	--	--
rs200722043^1,2		--	23846503(+)	`AGGAGA/GGGGTA`	4	R G	mis¹		0	--	--	--	--
rs199648352^1,2		--	23846532(+)	`TTCGCA/GGTGGA`	4	A	syn¹		0	--	--	--	--
rs201845674^1,2		--	23846564(+)	`CAAGGA/GCATCC`	4	D G	mis¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for CMTM5 (23846017 - 23848981 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CMTM5: --

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CMTM5 for disorders           About GeneDecksing

OMIM gene information: 607888    OMIM disorders: --

14 diseases for CMTM5:    About MalaCards

ovarian cystadenoma epithelial ovarian cancer cystadenoma multiple myeloma

ovarian cancer myeloid leukemia myeloma cervical carcinoma

cervicitis pancreatic cancer pancreatitis leukemia

carcinoma prostatitis

1 disease from the University of Copenhagen DISEASES database for CMTM5:

Ovarian cystadenoma

Human Genome Epidemiology (HuGE) Navigator: CMTM5 (1 document)

Export disorders for CMTM5 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CMTM5 gene, integrated from 9 sources (see all 13):
(articles sorted by number of sources associating them with CMTM5)

Utopia: connect your pdf to the dynamic
world of online information

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Identification of eight genes encoding chemokine-like factor superfamily members 1-8 (CKLFSF1-8) by in silico cloning and experimental validation. (PubMed id 12782130)^{1, 2} Han W.... Ma D. (2003)
[Abnormally lower expression of cmtm5 gene in bone ma rrow cells from patients with multiple myeloma] (PubMed id 20416169)^{1, 9} Niu J.H....Ruan G.R. (2010)
CMTM5 exhibits tumor suppressor activities and is frequently silenced by methylation in carcinoma cell lines. (PubMed id 17908965)^{1, 9} Shao L....Tao Q. (2007)
Aberrant expression of CKLF-like MARVEL transmembrane member 5 (CMTM5) by promoter methylation in myeloid leukemia. (PubMed id 21168207)¹ Niu J....Ruan G. (2011)
Reduced CMTM5 expression correlates with carcinogenes is in human epithelial ovarian cancer. (PubMed id 21841490)¹ Li P....Kong B. (2011)
[CMTM5 inhibits the tumor cell behavior of prostate c ancer by downregulation of HER2]. (PubMed id 20721248)¹ Xu T....Wang X.F. (2010)
CMTM5-v1, a four-transmembrane protein, presents a se creted form released via a vesicle-mediated secretory pathway. (PubMed id 20356458)¹ Li H....Han W. (2010)
CMTM5 induces apoptosis of pancreatic cancer cells an d has synergistic effects with TNF-alpha. (PubMed id 19577543)¹ Guo X....Han W. (2009)
CMTM5-v1 induces apoptosis in cervical carcinoma cells. (PubMed id 19124004)¹ Shao L....Han W. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 116173	HGNC: 19176	AceView: CKLFSF5	Ensembl:ENSG00000166091	euGenes: HUgn116173
ECgene: CMTM5	H-InvDB: CMTM5

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CMTM5	Pharmacogenomics, SNPs, Pathways

Intellectual Property for CMTM5 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for CMTM5 gene:
Search GeneIP for patents involving CMTM5

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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About This Section


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	OriGene Antibodies for CMTM5		OriGene shRNA RFP for CMTM5
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CMTM5		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CMTM5
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	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CMTM5
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CMTM5
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CMTM5
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CMTM5
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	GenScript Custom Purified and Recombinant Proteins Services for CMTM5		GenScript cDNA clones with any tag delivered in your preferred vector for CMTM5
	GenScript Custom Assay Services for CMTM5		GenScript Custom Superior Antibodies Services for CMTM5
	GenScript Custom overexpressing Cell Line Services for CMTM5		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
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ThermoFisher Antibodies for CMTM5

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CMTM5

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes CMTM5 gene at Home site.

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CMTM5 Gene

CKLF-like MARVEL transmembrane domain containing 5

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CMTM5 Gene

CKLF-like MARVEL transmembrane domain containing 5

Aliasesfor CMTM5 gene

Summariesfor CMTM5 gene

Genomic Viewsfor CMTM5 gene

Proteinsfor CMTM5 gene

Protein Domains /Familiesfor CMTM5 gene

Functionfor CMTM5 gene

Pathways & Interactionsfor CMTM5 gene

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for CMTM5 gene

Genomic Views
for CMTM5 gene

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for CMTM5 gene

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for CMTM5 gene

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for CMTM5 gene

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for CMTM5 gene

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for CMTM5 gene

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for CMTM5 gene

Expression
for CMTM5 gene

Orthologs
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for CMTM5 gene

Intellectual Property
for CMTM5 gene

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for CMTM5 gene