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Aliases for CMTM5 Gene

Aliases for CMTM5 Gene

  • CKLF Like MARVEL Transmembrane Domain Containing 5 2 3 5
  • Chemokine-Like Factor Superfamily Member 5 3 4
  • Chemokine-Like Factor Super Family 5 2 3
  • CKLFSF5 3 4
  • CKLF-Like MARVEL Transmembrane Domain-Containing Protein 5 3
  • CKLF-Like MARVEL Transmembrane Domain Containing 5 2
  • Chemokine-Like Factor Superfamily 5 2

External Ids for CMTM5 Gene

Previous HGNC Symbols for CMTM5 Gene


Previous GeneCards Identifiers for CMTM5 Gene

  • GC14P022916
  • GC14P023846
  • GC14P003962
  • GC14P023468
  • GC14P023549
  • GC14P023650
  • GC14P023683

Summaries for CMTM5 Gene

Entrez Gene Summary for CMTM5 Gene

  • This gene encodes a member of the chemokine-like factor superfamily. This family of genes encodes multi-pass membrane proteins that are similar to both the chemokine and the transmembrane 4 superfamilies of signaling molecules. The encoded protein may exhibit tumor suppressor activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

GeneCards Summary for CMTM5 Gene

CMTM5 (CKLF Like MARVEL Transmembrane Domain Containing 5) is a Protein Coding gene. GO annotations related to this gene include cytokine activity. An important paralog of this gene is CMTM3.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CMTM5 Gene

Genomics for CMTM5 Gene

Regulatory Elements for CMTM5 Gene

Enhancers for CMTM5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14F023442 1.2 VISTA FANTOM5 ENCODE 10.7 +66.4 66445 1.9 ZNF341 IKZF1 MYH6 MIR208B CMTM5 IL25 SLC22A17 MIR208A MYH7 NGDN
GH14F023140 1.3 FANTOM5 ENCODE 9.4 -234.8 -234753 2.9 ZFP64 ARID4B DMAP1 ZNF48 ZNF121 SLC30A9 ZNF143 MXD4 ZHX2 MIER2 SLC7A8 RNF212B CEBPE ACIN1 SLC22A17 C14orf93 CMTM5 IL25 DHRS4-AS1 RNU6-1138P
GH14F023279 0.9 ENCODE 10.5 -96.2 -96222 2.1 HDAC1 PKNOX1 CBX3 ARNT TBL1XR1 DEAF1 CBX5 GATA2 FOS CREM PABPN1 CMTM5 MIR208B ACIN1 ENSG00000157306 ZFHX2 HOMEZ PIR53909 HMGN2P1
GH14F023328 0.8 ENCODE 11.2 -48.6 -48602 0.2 ELF3 CTCF ZSCAN9 RAD21 RFX5 FOXK2 POLR2A SCRT2 ZNF143 SMC3 SLC22A17 EFS CMTM5 HOMEZ BCL2L2 PPP1R3E MIR208A IL25 MYH6 MIR208B
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CMTM5 on UCSC Golden Path with GeneCards custom track

Genomic Location for CMTM5 Gene

23,376,808 bp from pter
23,379,772 bp from pter
2,965 bases
Plus strand

Genomic View for CMTM5 Gene

Genes around CMTM5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CMTM5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CMTM5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CMTM5 Gene

Proteins for CMTM5 Gene

  • Protein details for CMTM5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    CKLF-like MARVEL transmembrane domain-containing protein 5
    Protein Accession:
    Secondary Accessions:
    • E9PH91
    • Q5PY48

    Protein attributes for CMTM5 Gene

    223 amino acids
    Molecular mass:
    24653 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CMTM5 Gene

neXtProt entry for CMTM5 Gene

Post-translational modifications for CMTM5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CMTM5 Gene

Domains & Families for CMTM5 Gene

Gene Families for CMTM5 Gene

Protein Domains for CMTM5 Gene


Graphical View of Domain Structure for InterPro Entry



  • Contains 1 MARVEL domain.
  • Belongs to the chemokine-like factor family.
  • Contains 1 MARVEL domain.
  • Belongs to the chemokine-like factor family.
genes like me logo Genes that share domains with CMTM5: view

Function for CMTM5 Gene

Gene Ontology (GO) - Molecular Function for CMTM5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IEA --
GO:0005515 protein binding IPI 21516116
genes like me logo Genes that share ontologies with CMTM5: view
genes like me logo Genes that share phenotypes with CMTM5: view

Animal Models for CMTM5 Gene

MGI Knock Outs for CMTM5:

Animal Model Products

miRNA for CMTM5 Gene

miRTarBase miRNAs that target CMTM5

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CMTM5 Gene

Localization for CMTM5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CMTM5 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CMTM5 gene
Compartment Confidence
plasma membrane 3
extracellular 3
lysosome 1

Gene Ontology (GO) - Cellular Components for CMTM5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA,IBA --
genes like me logo Genes that share ontologies with CMTM5: view

Pathways & Interactions for CMTM5 Gene

SuperPathways for CMTM5 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CMTM5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006935 chemotaxis IEA --
GO:0045662 negative regulation of myoblast differentiation IEA --
genes like me logo Genes that share ontologies with CMTM5: view

No data available for Pathways by source and SIGNOR curated interactions for CMTM5 Gene

Transcripts for CMTM5 Gene

Unigene Clusters for CMTM5 Gene

CKLF-like MARVEL transmembrane domain containing 5:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CMTM5 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3 ^ 4 ^ 5 ^ 6
SP2: - - - -
SP3: -
SP4: - -
SP5: -
SP6: - - -
SP7: - -

Relevant External Links for CMTM5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CMTM5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CMTM5 Gene

mRNA differential expression in normal tissues according to GTEx for CMTM5 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x12.9) and Brain - Substantia nigra (x6.3).

Protein differential expression in normal tissues from HIPED for CMTM5 Gene

This gene is overexpressed in Platelet (40.1), Peripheral blood mononuclear cells (12.9), and Frontal cortex (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CMTM5 Gene

Protein tissue co-expression partners for CMTM5 Gene

NURSA nuclear receptor signaling pathways regulating expression of CMTM5 Gene:


SOURCE GeneReport for Unigene cluster for CMTM5 Gene:


mRNA Expression by UniProt/SwissProt for CMTM5 Gene:

Tissue specificity: Highly expressed in the brain.
genes like me logo Genes that share expression patterns with CMTM5: view

Orthologs for CMTM5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CMTM5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CMTM5 34 35
  • 99.36 (n)
(Canis familiaris)
Mammalia CMTM5 34 35
  • 90.6 (n)
(Bos Taurus)
Mammalia CMTM5 34 35
  • 90.38 (n)
(Mus musculus)
Mammalia Cmtm5 34 16 35
  • 86.97 (n)
(Rattus norvegicus)
Mammalia Cmtm5 34
  • 86.75 (n)
(Monodelphis domestica)
Mammalia CMTM5 35
  • 46 (a)
(Gallus gallus)
Aves -- 35
  • 29 (a)
(Anolis carolinensis)
Reptilia CMTM5 35
  • 43 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cmtm5 34
  • 58.52 (n)
(Danio rerio)
Actinopterygii zgc:136605 35
  • 22 (a)
Species where no ortholog for CMTM5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CMTM5 Gene

Gene Tree for CMTM5 (if available)
Gene Tree for CMTM5 (if available)

Paralogs for CMTM5 Gene

Paralogs for CMTM5 Gene

(1) SIMAP similar genes for CMTM5 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CMTM5: view

Variants for CMTM5 Gene

Sequence variations from dbSNP and Humsavar for CMTM5 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1076755 -- 23,378,372(-) AAGCA(A/G)ATGAA intron-variant, reference, synonymous-codon
rs111290798 -- 23,378,786(+) CAGCC(A/G)CTGTC intron-variant, reference, missense
rs112378285 -- 23,375,042(+) AGGTG(G/T)GTGGA intron-variant, upstream-variant-2KB
rs1124053 -- 23,375,770(-) CCGCC(A/G/T)GTAGA upstream-variant-2KB, reference, synonymous-codon, missense
rs113476877 -- 23,377,379(+) GCTGG(C/T)AACAG splice-donor-variant

Variation tolerance for CMTM5 Gene

Residual Variation Intolerance Score: 67.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.56; 44.51% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CMTM5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CMTM5 Gene

Disorders for CMTM5 Gene

Relevant External Links for CMTM5

Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CMTM5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CMTM5 Gene

Publications for CMTM5 Gene

  1. [Abnormally lower expression of cmtm5 gene in bone marrow cells from patients with multiple myeloma]. (PMID: 20416169) Niu J.H. … Ruan G.R. (Zhongguo Shi Yan Xue Ye Xue Za Zhi 2010) 3 22 64
  2. CMTM5 exhibits tumor suppressor activities and is frequently silenced by methylation in carcinoma cell lines. (PMID: 17908965) Shao L. … Tao Q. (Clin. Cancer Res. 2007) 3 22 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Identification of eight genes encoding chemokine-like factor superfamily members 1-8 (CKLFSF1-8) by in silico cloning and experimental validation. (PMID: 12782130) Han W. … Ma D. (Genomics 2003) 3 4 64
  5. CMTM5 is reduced in prostate cancer and inhibits cancer cell growth in vitro and in vivo. (PMID: 25387568) Xiao Y. … Wang X. (Clin Transl Oncol 2015) 3 64

Products for CMTM5 Gene

Sources for CMTM5 Gene

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