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Aliases for CMTM4 Gene

Aliases for CMTM4 Gene

  • CKLF-Like MARVEL Transmembrane Domain Containing 4 2 3
  • CKLFSF4 3 4 6
  • Chemokine-Like Factor Superfamily Member 4 3 4
  • Chemokine-Like Factor Super Family 4 2 3
  • CKLF-Like MARVEL Transmembrane Domain-Containing Protein 4 3
  • Chemokine-Like Factor Superfamily 4 2

External Ids for CMTM4 Gene

Previous HGNC Symbols for CMTM4 Gene


Previous GeneCards Identifiers for CMTM4 Gene

  • GC16M065207
  • GC16M066648
  • GC16M052524

Summaries for CMTM4 Gene

Entrez Gene Summary for CMTM4 Gene

  • This gene belongs to the chemokine-like factor gene superfamily, a novel family that is similar to the chemokine and the transmembrane 4 superfamilies of signaling molecules. This gene is one of several chemokine-like factor genes located in a cluster on chromosome 16. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for CMTM4 Gene

CMTM4 (CKLF-Like MARVEL Transmembrane Domain Containing 4) is a Protein Coding gene. GO annotations related to this gene include cytokine activity. An important paralog of this gene is CMTM6.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CMTM4 Gene

Genomics for CMTM4 Gene

Regulatory Elements for CMTM4 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CMTM4 Gene

66,614,750 bp from pter
66,696,707 bp from pter
81,958 bases
Minus strand

Genomic View for CMTM4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CMTM4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CMTM4 Gene

Proteins for CMTM4 Gene

  • Protein details for CMTM4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    CKLF-like MARVEL transmembrane domain-containing protein 4
    Protein Accession:
    Secondary Accessions:
    • Q52M40
    • Q8IZR4
    • Q8IZV1

    Protein attributes for CMTM4 Gene

    234 amino acids
    Molecular mass:
    25828 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CMTM4 Gene


neXtProt entry for CMTM4 Gene

Proteomics data for CMTM4 Gene at MOPED

Post-translational modifications for CMTM4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CMTM4 Gene

No data available for DME Specific Peptides for CMTM4 Gene

Domains for CMTM4 Gene

Gene Families for CMTM4 Gene

Protein Domains for CMTM4 Gene


Suggested Antigen Peptide Sequences for CMTM4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 MARVEL domain.
  • Belongs to the chemokine-like factor family.
  • Contains 1 MARVEL domain.
  • Belongs to the chemokine-like factor family.
genes like me logo Genes that share domains with CMTM4: view

Function for CMTM4 Gene

Gene Ontology (GO) - Molecular Function for CMTM4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IEA --
genes like me logo Genes that share ontologies with CMTM4: view

Phenotypes for CMTM4 Gene

genes like me logo Genes that share phenotypes with CMTM4: view

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CMTM4

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for CMTM4 Gene

Localization for CMTM4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CMTM4 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for CMTM4 Gene COMPARTMENTS Subcellular localization image for CMTM4 gene
Compartment Confidence
extracellular 3
plasma membrane 3
golgi apparatus 2

Gene Ontology (GO) - Cellular Components for CMTM4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IEA --
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CMTM4: view

Pathways for CMTM4 Gene

SuperPathways for CMTM4 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for CMTM4 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: ENSP00000333833 for CMTM4 Gene via STRING

Gene Ontology (GO) - Biological Process for CMTM4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006935 chemotaxis IEA --
genes like me logo Genes that share ontologies with CMTM4: view

No data available for Pathways by source for CMTM4 Gene

Transcripts for CMTM4 Gene

Unigene Clusters for CMTM4 Gene

CKLF-like MARVEL transmembrane domain containing 4:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CMTM4

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CMTM4 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5
SP1: -
SP2: -

Relevant External Links for CMTM4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CMTM4 Gene

mRNA expression in normal human tissues for CMTM4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for CMTM4 Gene

This gene is overexpressed in Spleen (22.5), Lung (17.4), and Retina (7.2).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for CMTM4 Gene

SOURCE GeneReport for Unigene cluster for CMTM4 Gene Hs.643961

mRNA Expression by UniProt/SwissProt for CMTM4 Gene

Tissue specificity: Highly expressed in testis and prostate.
genes like me logo Genes that share expressions with CMTM4: view

Expression partners for CMTM4 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for CMTM4 Gene

Orthologs for CMTM4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CMTM4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CMTM4 35
  • 94.55 (n)
  • 95.67 (a)
CMTM4 36
  • 96 (a)
(Mus musculus)
Mammalia Cmtm4 35
  • 92.31 (n)
  • 95.67 (a)
Cmtm4 16
Cmtm4 36
  • 96 (a)
(Pan troglodytes)
Mammalia CMTM4 35
  • 99.86 (n)
  • 99.57 (a)
CMTM4 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Cmtm4 35
  • 91.83 (n)
  • 94.23 (a)
(Canis familiaris)
Mammalia CMTM4 36
  • 71 (a)
(Monodelphis domestica)
Mammalia CMTM4 36
  • 89 (a)
(Ornithorhynchus anatinus)
Mammalia CMTM4 36
  • 87 (a)
(Gallus gallus)
Aves CMTM4 35
  • 80.68 (n)
  • 82.61 (a)
CMTM4 36
  • 81 (a)
(Anolis carolinensis)
Reptilia CMTM4 36
  • 78 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100498042 35
  • 69.65 (n)
  • 69.15 (a)
(Danio rerio)
Actinopterygii cmtm4 35
  • 67.97 (n)
  • 66.67 (a)
cmtm4 36
  • 65 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2454 36
  • 26 (a)
Species with no ortholog for CMTM4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CMTM4 Gene

Gene Tree for CMTM4 (if available)
Gene Tree for CMTM4 (if available)

Paralogs for CMTM4 Gene

Paralogs for CMTM4 Gene

(2) SIMAP similar genes for CMTM4 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CMTM4: view

Variants for CMTM4 Gene

Sequence variations from dbSNP and Humsavar for CMTM4 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs48573 -- 66,638,154(-) CACAG(A/G)TGAAC intron-variant
rs165056 -- 66,660,940(-) GGGAG(C/T)CAGCT intron-variant
rs165057 -- 66,648,393(-) AAGAT(A/G)TTAAT intron-variant
rs165058 -- 66,634,165(-) ACCAC(A/G)CCCAG intron-variant
rs165202 -- 66,651,246(-) TGGTG(C/G)GGAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CMTM4 Gene

Variant ID Type Subtype PubMed ID
nsv906786 CNV Loss 21882294

Relevant External Links for CMTM4 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CMTM4 Gene

Disorders for CMTM4 Gene

No disorders were found for CMTM4 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for CMTM4 Gene

Publications for CMTM4 Gene

  1. Identification of eight genes encoding chemokine-like factor superfamily members 1-8 (CKLFSF1-8) by in silico cloning and experimental validation. (PMID: 12782130) Han W. … Ma D. (Genomics 2003) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  3. Identification and characterization of CMTM4, a novel gene with inhibitory effects on HeLa cell growth through Inducing G2/M phase accumulation. (PMID: 20213316) Plate M. … Han W. (Mol. Cells 2010) 3
  4. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4

Products for CMTM4 Gene

Sources for CMTM4 Gene

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