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CMTM4 Gene

protein-coding   GIFtS: 47
GCID: GC16M066648

CKLF-Like MARVEL Transmembrane Domain Containing 4

(Previous names: chemokine-like factor super family 4, chemokine-like factor...)
(Previous symbol: CKLFSF4)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
CKLF-Like MARVEL Transmembrane Domain Containing 41 2
CKLFSF41 2 3 5
Chemokine-Like Factor Super Family 41 2
Chemokine-Like Factor Superfamily Member 42 3
Chemokine-Like Factor Superfamily 41
CKLF-Like MARVEL Transmembrane Domain-Containing Protein 42

External Ids:    HGNC: 191751   Entrez Gene: 1462232   Ensembl: ENSG000001837237   OMIM: 6078875   UniProtKB: Q8IZR53   

Export aliases for CMTM4 gene to outside databases

Previous GC identifers: GC16M065207 GC16M052524


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CMTM4 Gene:
This gene belongs to the chemokine-like factor gene superfamily, a novel family that is similar to the chemokine
and the transmembrane 4 superfamilies of signaling molecules. This gene is one of several chemokine-like factor
genes located in a cluster on chromosome 16. Alternatively spliced transcript variants encoding different
isoforms have been identified. (provided by RefSeq, Jul 2008)

GeneCards Summary for CMTM4 Gene:
CMTM4 (CKLF-like MARVEL transmembrane domain containing 4) is a protein-coding gene. Diseases associated with CMTM4 include prostatitis. GO annotations related to this gene include cytokine activity. An important paralog of this gene is CMTM6.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000016.10  NC_018927.2  NT_010498.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the CMTM4 gene promoter:
         NRSF form 1   NRSF form 2   AP-2gamma   Cdc5   Ik-2   POU2F1   HOXA5   POU2F1a   LyF-1   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCMTM4 promoter sequence
   Search Chromatin IP Primers for CMTM4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CMTM4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q21-q22.1   Ensembl cytogenetic band:  16q22.1   HGNC cytogenetic band: 16q22.1-q22.3

CMTM4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CMTM4 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M066648:  view genomic region     (about GC identifiers)

Start:
66,648,653 bp from pter      End:
66,730,610 bp from pter
Size:
81,958 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: CKLF4_HUMAN, Q8IZR5 (See protein sequence)
Recommended Name: CKLF-like MARVEL transmembrane domain-containing protein 4  
Size: 234 amino acids; 25828 Da
Secondary accessions: Q52M40 Q8IZR4 Q8IZV1
Alternative splicing: 3 isoforms:  Q8IZR5-1   Q8IZR5-2   Q8IZR5-3   

Explore the universe of human proteins at neXtProt for CMTM4: NX_Q8IZR5

Explore proteomics data for CMTM4 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CMTM4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_848933.1  NP_852662.1  

    ENSEMBL proteins: 
     ENSP00000333833   ENSP00000464316   ENSP00000377666   ENSP00000456380  

    CMTM4 Human Recombinant Protein Products:

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    Novus Biologicals CMTM4 Proteins
    Novus Biologicals CMTM4 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    CMTM4 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Novus Biologicals CMTM4 Antibodies
    Abcam antibodies for CMTM4
    Browse Antibodies at Cloud-Clone Corp.
    Search ThermoFisher Antibodies for CMTM4
    LSBio Antibodies in human, mouse, rat for CMTM4

    CMTM4 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for CMTM4
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    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR008253 Marvel

    Graphical View of Domain Structure for InterPro Entry Q8IZR5

    ProtoNet protein and cluster: Q8IZR5

    1 Blocks protein domain: IPB008253 Marvel

    UniProtKB/Swiss-Prot: CKLF4_HUMAN, Q8IZR5
    Similarity: Belongs to the chemokine-like factor family
    Similarity: Contains 1 MARVEL domain


    CMTM4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005125cytokine activity IEA--
         
    CMTM4 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for CMTM4:
     Cell division defect  Increased G1 DNA content  Increased cell number in G1, a 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CMTM4
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CMTM4
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CMTM4

    miRNA
    Products:
        
    miRTarBase miRNAs that target CMTM4:
    hsa-mir-125b-5p (MIRT045989), hsa-mir-23b-3p (MIRT046380), hsa-mir-186-5p (MIRT021171), hsa-mir-375 (MIRT019833), hsa-mir-24-3p (MIRT030538), hsa-mir-373-3p (MIRT003843), hsa-mir-124-3p (MIRT022566), hsa-mir-503-5p (MIRT041117)

    Block miRNA regulation of human, mouse, rat CMTM4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CMTM4 (see all 98):
    hsa-miR-579 hsa-miR-642a hsa-miR-520f hsa-miR-607 hsa-miR-1321 hsa-miR-300 hsa-miR-106a hsa-miR-30d
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CMTM4

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 2): CMTM4 (NM_178818)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CMTM4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CMTM4

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for CMTM4 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CMTM4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CKLF4_HUMAN, Q8IZR5: Membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular3
    plasma membrane3
    golgi apparatus2

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IEA--
    GO:0016020membrane ----
    GO:0016021integral component of membrane IEA--

    CMTM4 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Array including CMTM4: 
              Chemokines & Receptors in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for CMTM4

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for CMTM4 (ENSP000003338334) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TPD52L1ENSP000003573874STRING: ENSP00000357387
    TPD52L2ENSP000002171214STRING: ENSP00000217121
    APPL1ENSP000002882664STRING: ENSP00000288266
    MRPL2ENSP000003734044STRING: ENSP00000373404
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006935chemotaxis IEA--

    CMTM4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CMTM4 (CKLF4)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CMTM4 gene (2 alternative transcripts): 
    NM_178818.2  NM_181521.2  

    Unigene Cluster for CMTM4:

    CKLF-like MARVEL transmembrane domain containing 4
    Hs.643961  [show with all ESTs]
    Unigene Representative Sequence: NM_181521
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000581487(uc021tjv.1) ENST00000330687(uc002epz.3 uc002eqa.3)
    ENST00000561680 ENST00000394106 ENST00000563952
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CMTM4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CMTM4 (see all 98):
    hsa-miR-579 hsa-miR-642a hsa-miR-520f hsa-miR-607 hsa-miR-1321 hsa-miR-300 hsa-miR-106a hsa-miR-30d
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for CMTM4
    Predesigned siRNA for gene silencing in human, mouse, rat CMTM4
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    OriGene ORF clones in mouse, rat for CMTM4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CMTM4 (NM_178818)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CMTM4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CMTM4
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for CMTM4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CMTM4
      QuantiTect SYBR Green Assays in human, mouse, rat CMTM4
      QuantiFast Probe-based Assays in human, mouse, rat CMTM4

    Additional mRNA sequence: 

    AF479814.1 AF521889.1 AF521890.1 AK000855.1 AK126493.1 AL157468.1 BC093679.1 CR933620.1 

    5 DOTS entries:

    DT.75104817  DT.87016626  DT.97763940  DT.100788480  DT.97790417 

    Selected AceView cDNA sequences (see all 192):

    BQ004582 CA394786 AI393152 BE673546 BM704006 Z43239 CB155027 AL157468 
    BM713573 Z44471 AF521889 BQ638403 BU739598 CB154957 NM_181521 AW103844 
    CB152102 AW771507 AI304592 AI880075 BM828870 AK126493 BE168307 AI192149 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for CMTM4    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5
    SP1:                                -         
    SP2:        -                                 
    SP3:                                          


    ECgene alternative splicing isoforms for CMTM4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CMTM4 expression in normal human tissues (normalized intensities)      CMTM4 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGGAACTTG
    CMTM4 Expression
    About this image


    CMTM4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    CMTM4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CMTM4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.643961

    UniProtKB/Swiss-Prot: CKLF4_HUMAN, Q8IZR5
    Tissue specificity: Highly expressed in testis and prostate

        Pathway & Disease-focused RT2 Profiler PCR Array including CMTM4: 
              Chemokines & Receptors in human mouse rat

    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for CMTM4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CMTM4
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CMTM4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CMTM4 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cmtm41 , 5 CKLF-like MARVEL transmembrane domain containing 41, 5 92.31(n)1
    95.67(a)1
      8 (53.04 cM)5
    974871  NM_153582.51  NP_705810.21 
     1043481915 
    chicken
    (Gallus gallus)
    Aves CMTM41 CKLF-like MARVEL transmembrane domain containing 4 80.68(n)
    82.61(a)
      415794  XM_414155.4  XP_414155.3 
    lizard
    (Anolis carolinensis)
    Reptilia CMTM46
    CKLF-like MARVEL transmembrane domain containing 4...
    78(a)
    1 ↔ 1
    GL343295.1(112990-136855)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004980421 CKLF-like MARVEL transmembrane domain-containing protein more 69.65(n)
    69.15(a)
      100498042  XM_002933649.2  XP_002933695.1 
    zebrafish
    (Danio rerio)
    Actinopterygii cmtm41 CKLF-like MARVEL transmembrane domain containing 4 67.97(n)
    66.67(a)
      436765  NM_001002492.1  NP_001002492.1 


    ENSEMBL Gene Tree for CMTM4 (if available)
    TreeFam Gene Tree for CMTM4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CMTM4 gene
    CMTM62  
    2 SIMAP similar genes for CMTM4 using alignment to 2 protein entries:     CKLF4_HUMAN (see all proteins):
    CMTM6    CMTM3

    CMTM4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CMTM4 (see all 1337)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1825404391,2
    --52607770(+) TTTTGA/GGACGG 2 -- int10--------
    rs1460474131,2
    --66648489(+) CCACCA/TTGTAA 2 -- ds50010--------
    rs1388288191,2
    C--66648543(+) CACCCC/TGAGGA 2 -- ds50010--------
    rs1921351661,2
    --66648749(+) ACATAC/GAAAAA 2 -- ut310--------
    rs45380031,2
    C,H--66648996(+) TAAACC/TTAAGT 2 -- ut316Minor allele frequency- T:0.00NS EA NA 422
    rs1411840071,2
    --66649054(+) CTGCCA/GAAATG 2 -- ut310--------
    rs1850669871,2
    --66649086(+) TGTGAC/TAGTTG 2 -- ut310--------
    rs794250041,2
    C--66649108(+) CCCCAA/GAAGTG 2 -- ut310--------
    rs1893015201,2
    --66649175(+) GACTTC/GACTTC 2 -- ut310--------
    rs1808660401,2
    --66649229(+) ACCAAA/GAGCTA 2 -- ut310--------

    HapMap Linkage Disequilibrium report for CMTM4 (66648653 - 66730610 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for CMTM4:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv906786CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CMTM4
    DNA2.0 Custom Variant and Variant Library Synthesis for CMTM4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607887    OMIM disorders: --

    1 disease for CMTM4:    About MalaCards
    prostatitis


    CMTM4 for disorders           About GeneDecksing


    Export disorders for CMTM4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CMTM4 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with CMTM4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of eight genes encoding chemokine-like factor superfamily members 1-8 (CKLFSF1-8) by in silico cloning and experimental validation. (PubMed id 12782130)1, 2, 3 Han W.... Ma D. (Genomics 2003)
    2. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)
    3. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    4. Identification and characterization of CMTM4, a novel gene with inhibitory effects on HeLa cell growth through Inducing G2/M phase accumulation. (PubMed id 20213316)1 Plate M....Han W. (Mol. Cells 2010)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    8. (PubMed id )2 
    9. CMTM3, located at the critical tumor suppressor locus 16q22.1, is silenced by CpG methylation in carcinomas and inhibits tumor cell growth through inducing apoptosis. (PubMed id 19509237)9 Wang Y....Han W. (Cancer Res. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 146223 HGNC: 19175 AceView: CKLFSF4 Ensembl:ENSG00000183723 euGenes: HUgn146223
    ECgene: CMTM4 H-InvDB: CMTM4

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CMTM4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CMTM4 gene:
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    GeneCards and IP:
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