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Aliases for CMTM4 Gene

Aliases for CMTM4 Gene

  • CKLF Like MARVEL Transmembrane Domain Containing 4 2 3
  • CKLF-Like MARVEL Transmembrane Domain Containing 4 2 3 5
  • Chemokine-Like Factor Superfamily Member 4 3 4
  • Chemokine-Like Factor Super Family 4 2 3
  • CKLFSF4 3 4
  • Chemokine-Like Factor Superfamily 4 2

External Ids for CMTM4 Gene

Previous HGNC Symbols for CMTM4 Gene

  • CKLFSF4

Previous GeneCards Identifiers for CMTM4 Gene

  • GC16M065207
  • GC16M066648
  • GC16M052524
  • GC16M066616

Summaries for CMTM4 Gene

Entrez Gene Summary for CMTM4 Gene

  • This gene belongs to the chemokine-like factor gene superfamily, a novel family that is similar to the chemokine and the transmembrane 4 superfamilies of signaling molecules. This gene is one of several chemokine-like factor genes located in a cluster on chromosome 16. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for CMTM4 Gene

CMTM4 (CKLF Like MARVEL Transmembrane Domain Containing 4) is a Protein Coding gene. GO annotations related to this gene include cytokine activity. An important paralog of this gene is CMTM6.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CMTM4 Gene

Genomics for CMTM4 Gene

Regulatory Elements for CMTM4 Gene

Promoters for CMTM4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CMTM4 on UCSC Golden Path with GeneCards custom track

Genomic Location for CMTM4 Gene

Chromosome:
16
Start:
66,598,214 bp from pter
End:
66,696,707 bp from pter
Size:
98,494 bases
Orientation:
Minus strand

Genomic View for CMTM4 Gene

Genes around CMTM4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CMTM4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CMTM4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CMTM4 Gene

Proteins for CMTM4 Gene

  • Protein details for CMTM4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IZR5-CKLF4_HUMAN
    Recommended name:
    CKLF-like MARVEL transmembrane domain-containing protein 4
    Protein Accession:
    Q8IZR5
    Secondary Accessions:
    • Q52M40
    • Q8IZR4
    • Q8IZV1

    Protein attributes for CMTM4 Gene

    Size:
    234 amino acids
    Molecular mass:
    25828 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CMTM4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CMTM4 Gene

Proteomics data for CMTM4 Gene at MOPED

Post-translational modifications for CMTM4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CMTM4 Gene

Antibody Products

No data available for DME Specific Peptides for CMTM4 Gene

Domains & Families for CMTM4 Gene

Gene Families for CMTM4 Gene

Protein Domains for CMTM4 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for CMTM4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IZR5

UniProtKB/Swiss-Prot:

CKLF4_HUMAN :
  • Contains 1 MARVEL domain.
  • Belongs to the chemokine-like factor family.
Domain:
  • Contains 1 MARVEL domain.
Family:
  • Belongs to the chemokine-like factor family.
genes like me logo Genes that share domains with CMTM4: view

Function for CMTM4 Gene

genes like me logo Genes that share phenotypes with CMTM4: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CMTM4

miRNA for CMTM4 Gene

miRTarBase miRNAs that target CMTM4

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CMTM4 Gene

Localization for CMTM4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CMTM4 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CMTM4 Gene COMPARTMENTS Subcellular localization image for CMTM4 gene
Compartment Confidence
plasma membrane 4
extracellular 3
golgi apparatus 2

Gene Ontology (GO) - Cellular Components for CMTM4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CMTM4: view

Pathways & Interactions for CMTM4 Gene

SuperPathways for CMTM4 Gene

No Data Available

Interacting Proteins for CMTM4 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000333833%0d%0a9606.ENSP00000373404%0d%0a9606.ENSP00000288266%0d%0a
Selected Interacting proteins: ENSP00000333833 for CMTM4 Gene via STRING

Gene Ontology (GO) - Biological Process for CMTM4 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CMTM4 Gene

Drugs & Compounds for CMTM4 Gene

No Compound Related Data Available

Transcripts for CMTM4 Gene

Unigene Clusters for CMTM4 Gene

CKLF-like MARVEL transmembrane domain containing 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CMTM4 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5
SP1: -
SP2: -
SP3:

Relevant External Links for CMTM4 Gene

GeneLoc Exon Structure for
CMTM4
ECgene alternative splicing isoforms for
CMTM4

Expression for CMTM4 Gene

mRNA expression in normal human tissues for CMTM4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CMTM4 Gene

This gene is overexpressed in Spleen (22.5), Lung (17.4), and Retina (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CMTM4 Gene



SOURCE GeneReport for Unigene cluster for CMTM4 Gene Hs.643961

mRNA Expression by UniProt/SwissProt for CMTM4 Gene

Q8IZR5-CKLF4_HUMAN
Tissue specificity: Highly expressed in testis and prostate.
genes like me logo Genes that share expression patterns with CMTM4: view

Protein tissue co-expression partners for CMTM4 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for CMTM4 Gene

Orthologs for CMTM4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CMTM4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CMTM4 35
  • 99.86 (n)
  • 99.57 (a)
CMTM4 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CMTM4 36
  • 96 (a)
OneToOne
CMTM4 35
  • 94.55 (n)
  • 95.67 (a)
dog
(Canis familiaris)
Mammalia CMTM4 36
  • 71 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cmtm4 16
Cmtm4 35
  • 92.31 (n)
  • 95.67 (a)
Cmtm4 36
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CMTM4 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CMTM4 36
  • 87 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cmtm4 35
  • 91.83 (n)
  • 94.23 (a)
chicken
(Gallus gallus)
Aves CMTM4 35
  • 80.68 (n)
  • 82.61 (a)
CMTM4 36
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CMTM4 36
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100498042 35
  • 69.65 (n)
  • 69.15 (a)
zebrafish
(Danio rerio)
Actinopterygii cmtm4 36
  • 65 (a)
OneToOne
cmtm4 35
  • 67.97 (n)
  • 66.67 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2454 36
  • 26 (a)
OneToMany
Species with no ortholog for CMTM4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CMTM4 Gene

ENSEMBL:
Gene Tree for CMTM4 (if available)
TreeFam:
Gene Tree for CMTM4 (if available)

Paralogs for CMTM4 Gene

Paralogs for CMTM4 Gene

(2) SIMAP similar genes for CMTM4 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CMTM4: view

Variants for CMTM4 Gene

Sequence variations from dbSNP and Humsavar for CMTM4 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs165056 -- 66,660,940(-) GGGAG(C/T)CAGCT intron-variant
rs165057 -- 66,648,393(-) AAGAT(A/G)TTAAT intron-variant
rs165058 -- 66,634,165(-) ACCAC(A/G)CCCAG intron-variant
rs165202 -- 66,651,246(-) TGGTG(C/G)GGAGA intron-variant
rs165203 -- 66,643,458(-) ctcta(C/T)taccc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CMTM4 Gene

Variant ID Type Subtype PubMed ID
nsv906786 CNV Loss 21882294

Variation tolerance for CMTM4 Gene

Residual Variation Intolerance Score: 63.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.69; 14.70% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CMTM4 Gene

HapMap Linkage Disequilibrium report
CMTM4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CMTM4 Gene

Disorders for CMTM4 Gene

Relevant External Links for CMTM4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CMTM4

No disorders were found for CMTM4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CMTM4 Gene

Publications for CMTM4 Gene

  1. Identification of eight genes encoding chemokine-like factor superfamily members 1-8 (CKLFSF1-8) by in silico cloning and experimental validation. (PMID: 12782130) Han W. … Ma D. (Genomics 2003) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 3
  4. Identification and characterization of CMTM4, a novel gene with inhibitory effects on HeLa cell growth through Inducing G2/M phase accumulation. (PMID: 20213316) Plate M. … Han W. (Mol. Cells 2010) 3
  5. CMTM3, located at the critical tumor suppressor locus 16q22.1, is silenced by CpG methylation in carcinomas and inhibits tumor cell growth through inducing apoptosis. (PMID: 19509237) Wang Y. … Han W. (Cancer Res. 2009) 23

Products for CMTM4 Gene

Sources for CMTM4 Gene

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