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Aliases for CMTM4 Gene

Aliases for CMTM4 Gene

  • CKLF Like MARVEL Transmembrane Domain Containing 4 2 3 5
  • Chemokine-Like Factor Superfamily Member 4 3 4
  • Chemokine-Like Factor Super Family 4 2 3
  • CKLFSF4 3 4
  • CKLF-Like MARVEL Transmembrane Domain-Containing Protein 4 3
  • CKLF-Like MARVEL Transmembrane Domain Containing 4 2
  • Chemokine-Like Factor Superfamily 4 2

External Ids for CMTM4 Gene

Previous HGNC Symbols for CMTM4 Gene

  • CKLFSF4

Previous GeneCards Identifiers for CMTM4 Gene

  • GC16M065207
  • GC16M066648
  • GC16M052524
  • GC16M066616

Summaries for CMTM4 Gene

Entrez Gene Summary for CMTM4 Gene

  • This gene belongs to the chemokine-like factor gene superfamily, a novel family that is similar to the chemokine and the transmembrane 4 superfamilies of signaling molecules. This gene is one of several chemokine-like factor genes located in a cluster on chromosome 16. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for CMTM4 Gene

CMTM4 (CKLF Like MARVEL Transmembrane Domain Containing 4) is a Protein Coding gene. GO annotations related to this gene include cytokine activity. An important paralog of this gene is CMTM6.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CMTM4 Gene

Genomics for CMTM4 Gene

Regulatory Elements for CMTM4 Gene

Enhancers for CMTM4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16F066650 1.3 Ensembl ENCODE 18.1 +44.1 44128 4.0 ATF1 PKNOX1 ARID4B FEZF1 ZNF2 ZNF121 GATA2 ZNF143 YY2 KAT8 CMTM4 BEAN1 TK2 DYNC1LI2 LOC106699570 CMTM3 GC16P066646 GC16M066667
GH16F066659 1.3 Ensembl ENCODE 17.1 +35.2 35218 3.0 PKNOX1 CREB3L1 ARID4B SIN3A FEZF1 DMAP1 YBX1 ZNF2 SLC30A9 CBX5 BEAN1 CMTM4 CA7 DYNC1LI2 LOC106699570 CES2 TK2 GC16M066667 GC16P066646
GH16F066739 1.2 Ensembl ENCODE 11.8 -44.7 -44722 3.9 ZNF133 RAD21 ZEB1 YY1 ZNF366 ZNF362 ZNF654 CEBPB ZEB2 POLR2H CMTM4 ACD BEAN1 CA7 CES2 KIAA0895L TERB1 ENSG00000260558 LOC106699570
GH16F066406 1.3 FANTOM5 ENCODE 9.8 +288.6 288621 4.1 MLX WRNIP1 ARID4B SIN3A DMAP1 ZNF48 ZNF2 SLC30A9 ZNF143 FOS LINC00920 KIAA0895L CDH5 CMTM2 CMTM4 DYNC1LI2 LOC106699570 CA7 RRAD CMTM3
GH16F066716 1 ENCODE 11.5 -21.1 -21080 1.9 PKNOX1 CREB3L1 ARID4B SIN3A ZNF48 YY1 GLIS2 ZNF766 ZNF143 ZNF207 TERB1 DYNC1LI2 LOC106699570 CMTM4 ENSG00000260465 GC16M066696
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CMTM4 on UCSC Golden Path with GeneCards custom track

Promoters for CMTM4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000272699 107 2001 ZNF48 ZNF2 GLIS2 KLF7 SP3 MXD4 REST SMARCA4 GLIS1 MXD3

Genomic Location for CMTM4 Gene

Chromosome:
16
Start:
66,598,214 bp from pter
End:
66,696,707 bp from pter
Size:
98,494 bases
Orientation:
Minus strand

Genomic View for CMTM4 Gene

Genes around CMTM4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CMTM4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CMTM4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CMTM4 Gene

Proteins for CMTM4 Gene

  • Protein details for CMTM4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IZR5-CKLF4_HUMAN
    Recommended name:
    CKLF-like MARVEL transmembrane domain-containing protein 4
    Protein Accession:
    Q8IZR5
    Secondary Accessions:
    • Q52M40
    • Q8IZR4
    • Q8IZV1

    Protein attributes for CMTM4 Gene

    Size:
    234 amino acids
    Molecular mass:
    25828 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CMTM4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CMTM4 Gene

Post-translational modifications for CMTM4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CMTM4 Gene

No data available for DME Specific Peptides for CMTM4 Gene

Domains & Families for CMTM4 Gene

Gene Families for CMTM4 Gene

Protein Domains for CMTM4 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for CMTM4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IZR5

UniProtKB/Swiss-Prot:

CKLF4_HUMAN :
  • Contains 1 MARVEL domain.
  • Belongs to the chemokine-like factor family.
Domain:
  • Contains 1 MARVEL domain.
Family:
  • Belongs to the chemokine-like factor family.
genes like me logo Genes that share domains with CMTM4: view

Function for CMTM4 Gene

Gene Ontology (GO) - Molecular Function for CMTM4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IEA --
genes like me logo Genes that share ontologies with CMTM4: view
genes like me logo Genes that share phenotypes with CMTM4: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CMTM4

miRNA for CMTM4 Gene

miRTarBase miRNAs that target CMTM4

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CMTM4 Gene

Localization for CMTM4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CMTM4 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CMTM4 gene
Compartment Confidence
plasma membrane 4
extracellular 3
golgi apparatus 2

Gene Ontology (GO) - Cellular Components for CMTM4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA,IBA --
genes like me logo Genes that share ontologies with CMTM4: view

Pathways & Interactions for CMTM4 Gene

SuperPathways for CMTM4 Gene

No Data Available

Interacting Proteins for CMTM4 Gene

Gene Ontology (GO) - Biological Process for CMTM4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006935 chemotaxis IEA --
genes like me logo Genes that share ontologies with CMTM4: view

No data available for Pathways by source and SIGNOR curated interactions for CMTM4 Gene

Transcripts for CMTM4 Gene

Unigene Clusters for CMTM4 Gene

CKLF-like MARVEL transmembrane domain containing 4:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CMTM4 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5
SP1: -
SP2: -
SP3:

Relevant External Links for CMTM4 Gene

GeneLoc Exon Structure for
CMTM4
ECgene alternative splicing isoforms for
CMTM4

Expression for CMTM4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CMTM4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CMTM4 Gene

This gene is overexpressed in Spleen (22.5), Lung (17.4), and Retina (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CMTM4 Gene



Protein tissue co-expression partners for CMTM4 Gene

NURSA nuclear receptor signaling pathways regulating expression of CMTM4 Gene:

CMTM4

SOURCE GeneReport for Unigene cluster for CMTM4 Gene:

Hs.643961

mRNA Expression by UniProt/SwissProt for CMTM4 Gene:

Q8IZR5-CKLF4_HUMAN
Tissue specificity: Highly expressed in testis and prostate.
genes like me logo Genes that share expression patterns with CMTM4: view

Primer Products

No data available for mRNA differential expression in normal tissues for CMTM4 Gene

Orthologs for CMTM4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CMTM4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CMTM4 34 35
  • 99.86 (n)
cow
(Bos Taurus)
Mammalia CMTM4 34 35
  • 94.55 (n)
mouse
(Mus musculus)
Mammalia Cmtm4 34 16 35
  • 92.31 (n)
rat
(Rattus norvegicus)
Mammalia Cmtm4 34
  • 91.83 (n)
oppossum
(Monodelphis domestica)
Mammalia CMTM4 35
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CMTM4 35
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CMTM4 35
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves CMTM4 34 35
  • 80.68 (n)
lizard
(Anolis carolinensis)
Reptilia CMTM4 35
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100498042 34
  • 69.65 (n)
zebrafish
(Danio rerio)
Actinopterygii cmtm4 34 35
  • 67.97 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2454 35
  • 26 (a)
OneToMany
Species where no ortholog for CMTM4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CMTM4 Gene

ENSEMBL:
Gene Tree for CMTM4 (if available)
TreeFam:
Gene Tree for CMTM4 (if available)

Paralogs for CMTM4 Gene

Paralogs for CMTM4 Gene

(2) SIMAP similar genes for CMTM4 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CMTM4: view

Variants for CMTM4 Gene

Sequence variations from dbSNP and Humsavar for CMTM4 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1031321 -- 66,668,824(+) GCTtt(A/T)aaaaa intron-variant
rs1045604 -- 66,614,889(-) CATGG(G/T)ACTTG intron-variant, utr-variant-3-prime
rs1045617 -- 66,614,818(-) TCAAC(A/C)CTAAT intron-variant, utr-variant-3-prime
rs10500539 -- 66,653,111(+) CCCCA(C/G)AATAC intron-variant
rs1060674 -- 66,662,745(-) AGCTG(G/T)TTCTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CMTM4 Gene

Variant ID Type Subtype PubMed ID
nsv1071337 CNV deletion 25765185

Variation tolerance for CMTM4 Gene

Residual Variation Intolerance Score: 63.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.69; 14.70% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CMTM4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CMTM4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CMTM4 Gene

Disorders for CMTM4 Gene

Relevant External Links for CMTM4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CMTM4

No disorders were found for CMTM4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CMTM4 Gene

Publications for CMTM4 Gene

  1. Identification of eight genes encoding chemokine-like factor superfamily members 1-8 (CKLFSF1-8) by in silico cloning and experimental validation. (PMID: 12782130) Han W. … Ma D. (Genomics 2003) 2 3 4 64
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  3. CMTM4 is frequently downregulated and functions as a tumour suppressor in clear cell renal cell carcinoma. (PMID: 26474560) Li T. … Han W. (J. Exp. Clin. Cancer Res. 2015) 3 64
  4. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H. … Mohammed S. (J. Proteome Res. 2013) 4 64
  5. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 3 64

Products for CMTM4 Gene

Sources for CMTM4 Gene

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