CMTM4 Gene
protein-coding GIFtS: 47
GCID: GC16M066648
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|
CKLF-like MARVEL transmembrane domain containing 4(Previous names: chemokine-like factor super family 4, chemokine-like factor...)
(Previous symbol: CKLFSF4)
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Aliases
for CMTM4 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| CKLF-Like MARVEL Transmembrane Domain Containing 41 2 | | CKLFSF41 2 3 | | Chemokine-Like Factor Super Family 41 2 | | Chemokine-Like Factor Superfamily Member 42 3 | | Chemokine-Like Factor Superfamily 41 | | CKLF-Like MARVEL Transmembrane Domain-Containing Protein 42 |
Export aliases for CMTM4 gene to outside databasesPrevious GC identifers: GC16M065207 GC16M052524 |
Summaries
for CMTM4 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CMTM4:
This gene belongs to the chemokine-like factor gene superfamily, a novel family that is similar to the chemokine andthe transmembrane 4 superfamilies of signaling molecules. This gene is one of several chemokine-like factor geneslocated in a cluster on chromosome 16. Alternatively spliced transcript variants encoding different isoforms have beenidentified. (provided by RefSeq, Jul 2008)
|
Genomic Views
for CMTM4 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000016.9 NC_018927.1 NT_010498.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CMTM4 gene promoter:
NRSF form 1 NRSF form 2 AP-2gamma Cdc5 Ik-2 POU2F1 HOXA5 POU2F1a LyF-1 Pax-4a
Other transcription factors
Search SABiosciences Chromatin IP Primers for CMTM4
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CMTM4 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 16q21-q22.1 Ensembl cytogenetic band: 16q22.1 HGNC cytogenetic band: 16q22.1-q22.3CMTM4 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 16 GeneLoc Exon Structure GeneLoc location for GC16M066648: view genomic region
(about GC identifiers)
Start:
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66,648,653 bp from pter |
End:
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66,730,610 bp from pter |
Size:
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81,958 bases |
Orientation:
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minus strand |
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Proteins
for CMTM4 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CKLF4_HUMAN, Q8IZR5 (See
protein sequence)Recommended Name: CKLF-like MARVEL transmembrane domain-containing protein 4 Size: 234 amino acids; 25828 Da
Subcellular location: Membrane; Multi-pass membrane protein
Secondary accessions: Q52M40 Q8IZR4 Q8IZV1Alternative splicing: 3 isoforms: Q8IZR5-1 Q8IZR5-2 Q8IZR5-3 Explore the universe of human proteins at neXtProt for CMTM4: NX_Q8IZR5
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8IZR5
CMTM4 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_848933.1 NP_852662.1
ENSEMBL proteins: ENSP00000333833 ENSP00000464316 ENSP00000377666 ENSP00000456380
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005615 | extracellular space |
IEA | -- | | GO:0016021 | integral to membrane |
IEA | -- |
CMTM4 for ontologies About GeneDecksing
CMTM4 Antibody Products:
Assay Products for CMTM4: |
Protein
Domains /
Families
for CMTM4 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CMTM4 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8IZR5ProtoNet protein and cluster: Q8IZR5 1 Blocks protein family: IPB008253 Marvel
UniProtKB/Swiss-Prot: CKLF4_HUMAN, Q8IZR5Similarity: Belongs to the chemokine-like factor familySimilarity: Contains 1 MARVEL domain |
Function
for CMTM4 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CMTM4 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CMTM4 (see all 2)
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CMTM4 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005125 | cytokine activity |
IEA | -- |
CMTM4 for ontologies About GeneDecksing
3 GenomeRNAi human phenotypes for CMTM4:
|
Pathways & Interactions
for CMTM4 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CMTM4
STRING Interaction
Network Preview (showing 4 interactants - click image to see more details)
4 Interacting proteins for CMTM4 (ENSP000003338334) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006935 | chemotaxis |
IEA | -- |
CMTM4 for ontologies About GeneDecksing
|
Drugs & Compounds
for CMTM4 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CMTM4
Search CenterWatch for drugs/clinical trials and news about CMTM4 / CKLF4
|
Transcripts
for CMTM4 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CMTM4 gene (2 alternative transcripts): NM_178818.2 NM_181521.2 Unigene Cluster for CMTM4: CKLF-like MARVEL transmembrane domain containing 4 Hs.643961 [show with all ESTs]Unigene Representative Sequence: NM_1815215 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000581487(uc021tjv.1) ENST00000330687(uc002epz.3 uc002eqa.3)
ENST00000561680 ENST00000394106 ENST00000563952
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CMTM4 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CMTM4 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): CMTM4 (NM_178818) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CMTM4 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CMTM4 |
Additional cDNA sequence: AF479814.1 AF521889.1 AF521890.1 AK000855.1 AK126493.1 AL157468.1 BC093679.1 CR933620.1 5 DOTS entries: DT.75104817 DT.87016626 DT.97763940 DT.100788480 DT.97790417 24/192 AceView cDNA sequences (see all 192): NM_178818 BX093351 BM713573 BE168307 BE465231 BU739598 BU685770 AL157468 AW103844 BM457958 CR600851 AW771507 AI277073 BQ638403 CB154957 BM704006 CB155027 AI288172 AF521889 Z43239 AI393152 CB142554 CB152102 AK126493
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for CMTM4 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 |
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| SP1: | | | | | | | | | | | - | | | | |
| SP2: | | | - | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for CMTM4
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Expression
for CMTM4 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CMTM4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAGGAACTTG
About this image
See CMTM4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CMTM4
SOURCE GeneReport for Unigene cluster: Hs.643961
UniProtKB/Swiss-Prot: CKLF4_HUMAN, Q8IZR5Tissue specificity: Highly expressed in testis and prostate
SABiosciences Expression via Pathway-Focused PCR Array including CMTM4:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CMTM4
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CMTM4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CMTM4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CMTM4 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CMTM4 |
Orthologs
for CMTM4 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for CMTM4 gene from 3/10 species (see all 10) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
CMTM41 |
CKLF-like MARVEL transmembrane domain containing 4 |
80.68(n)
82.61(a) |
|
415794 XM_414155.3 XP_414155.3 |
lizard
(Anolis carolinensis) |
Reptilia |
CMTM46 |
-- |
79(a) |
1 ↔ 1 |
GL343295.1(113598-136514) |
zebrafish
(Danio rerio) |
Actinopterygii |
cmtm41 |
CKLF-like MARVEL transmembrane domain containing 4 |
67.97(n)
66.67(a) |
|
436765 NM_001002492.1 NP_001002492.1 |
ENSEMBL Gene Tree for CMTM4 (if available)
TreeFam Gene Tree for CMTM4 (if available) |
Paralogs
for CMTM4 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CMTM4 gene
- CMTM62
2 SIMAP similar genes for CMTM4 using alignment to 2 protein entries: CKLF4_HUMAN (see all proteins):CMTM6 CMTM3
CMTM4 for paralogs About GeneDecksing
|
Genomic Variants
for CMTM4 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 16 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CMTM4 (66648653 - 66730610 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CMTM4: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CMTM4 |
|
Disorders
/ Diseases
for CMTM4 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CMTM4 for disorders About GeneDecksing
OMIM gene information: 607887
OMIM disorders: --
2  diseases for CMTM4: About MalaCardsprostatitis carcinoma
Export disorders for CMTM4 gene to outside databases
|
Publications
for CMTM4 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CMTM4 gene integrated from 9 sources:
(articles sorted by number of sources associating them with CMTM4) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification of eight genes encoding chemokine-like factor superfamily members 1-8 (CKLFSF1-8) by in silico cloning and experimental validation. (PubMed id 12782130)1, 2, 3 Han W.... Ma D. (2003)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Identification and characterization of CMTM4, a novel gene with inhibitory effects on HeLa cell growth through Inducing G2/M phase a ccumulation. (PubMed id 20213316)1 Plate M....Han W. (2010)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
- CMTM3, located at the critical tumor suppressor locus 16q22.1, is silenced by CpG methylation in carcinomas and inhibits tumor cell growth through inducing apoptosis. (PubMed id 19509237)9 Wang Y....Han W. (2009)
|
External Searches for CMTM4 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CMTM4 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CMTM4 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CMTM4 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CMTM4 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for CMTM4 gene:
Search GeneIP for patents involving CMTM4
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CMTM4 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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 | | | CMTM4 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CMTM4 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CMTM4 |
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