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CMTM3 Gene

protein-coding   GIFtS: 50
GCID: GC16P066637

CKLF-Like MARVEL Transmembrane Domain Containing 3

(Previous name: chemokine-like factor superfamily 3)
(Previous symbol: CKLFSF3)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
CKLF-Like MARVEL Transmembrane Domain Containing 31 2
CKLFSF31 2 3 5
Chemokine-Like Factor Superfamily Member 32 3
Chemokine-Like Factor Superfamily 31
BNAS22
CKLF-Like MARVEL Transmembrane Domain-Containing Protein 32

External Ids:    HGNC: 191741   Entrez Gene: 1239202   Ensembl: ENSG000001409317   OMIM: 6078865   UniProtKB: Q96MX03   

Export aliases for CMTM3 gene to outside databases

Previous GC identifers: GC16P065196 GC16P052514


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CMTM3 Gene:
This gene belongs to the chemokine-like factor gene superfamily, a novel family that is similar to the chemokine
and the transmembrane 4 superfamilies of signaling molecules. This gene is one of several chemokine-like factor
genes located in a cluster on chromosome 16. Alternatively spliced transcript variants containing different 5'
UTRs, but encoding the same protein, have been identified. (provided by RefSeq, Jul 2008)

GeneCards Summary for CMTM3 Gene:
CMTM3 (CKLF-like MARVEL transmembrane domain containing 3) is a protein-coding gene. GO annotations related to this gene include cytokine activity. An important paralog of this gene is CMTM5.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NT_010498.16  NC_018927.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CMTM3 gene promoter:
         NF-kappaB1   NF-kappaB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCMTM3 promoter sequence
   Search Chromatin IP Primers for CMTM3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CMTM3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q21   Ensembl cytogenetic band:  16q21   HGNC cytogenetic band: 16q22.1-q22.3

CMTM3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CMTM3 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P066637:  view genomic region     (about GC identifiers)

Start:
66,637,777 bp from pter      End:
66,647,795 bp from pter
Size:
10,019 bases      Orientation:
plus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for CMTM3

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CKLF3_HUMAN, Q96MX0 (See protein sequence)
Recommended Name: CKLF-like MARVEL transmembrane domain-containing protein 3  
Size: 182 amino acids; 19714 Da
Secondary accessions: A6NCL9 Q8IUU8 Q8IWQ6 Q8IYE2 Q8IZ39 Q8IZ59
Alternative splicing: 2 isoforms:  Q96MX0-1   Q96MX0-2   

Explore the universe of human proteins at neXtProt for CMTM3: NX_Q96MX0

Explore proteomics data for CMTM3 at MOPED


See CMTM3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (2 alternative transcripts): 
NP_653202.1  NP_853531.1  

ENSEMBL proteins: 
 ENSP00000457451   ENSP00000400482   ENSP00000454628   ENSP00000455758   ENSP00000354579  
 ENSP00000461758   ENSP00000462554   ENSP00000455851   ENSP00000457589   ENSP00000456426  
 ENSP00000462613   ENSP00000460330   ENSP00000461654   ENSP00000457923   ENSP00000353199  

CMTM3 Human Recombinant Protein Products:

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Novus Biologicals CMTM3 Protein
Novus Biologicals CMTM3 Lysates
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Cloud-Clone Corp. Proteins for CMTM3

 
Search eBioscience for Proteins for CMTM3 

 
antibodies-online proteins for CMTM3 (2 products) 

 
Search antibodies-online for peptides for CMTM3

CMTM3 Antibody Products:

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antibodies-online antibodies for CMTM3 (9 products) 

CMTM3 Assay Products:

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Cloud-Clone Corp. ELISAs for CMTM3
Cloud-Clone Corp. CLIAs for CMTM3
Search eBioscience for ELISAs for CMTM3 
antibodies-online kits for CMTM3 (4 products) 


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro protein domain:
 IPR008253 Marvel

Graphical View of Domain Structure for InterPro Entry Q96MX0

ProtoNet protein and cluster: Q96MX0

1 Blocks protein domain: IPB008253 Marvel

UniProtKB/Swiss-Prot: CKLF3_HUMAN, Q96MX0
Similarity: Belongs to the chemokine-like factor family
Similarity: Contains 1 MARVEL domain


Find genes that share domains with CMTM3           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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     Gene Ontology (GO): 1 molecular function term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005125cytokine activity IEA--
     
Find genes that share ontologies with CMTM3           About GenesLikeMe


Animal Models:
   genOway: Develop your customized and physiologically relevant rodent model for CMTM3

miRNA
Products:
    
miRTarBase miRNAs that target CMTM3:
hsa-mir-132-3p (MIRT021850), hsa-mir-24-3p (MIRT030605), hsa-mir-124-3p (MIRT023087), hsa-mir-335-5p (MIRT018895)

Block miRNA regulation of human, mouse, rat CMTM3 using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate CMTM3 (see all 13):
hsa-miR-3163 hsa-miR-3140-3p hsa-miR-622 hsa-miR-3175 hsa-miR-105 hsa-miR-4287 hsa-miR-135b hsa-miR-629*
SwitchGear 3'UTR luciferase reporter plasmidCMTM3 3' UTR sequence
Inhib. RNA
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OriGene RNAi products in human, mouse, rat for CMTM3
Predesigned siRNA for gene silencing in human, mouse, rat CMTM3

Gene Editing
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DNA2.0 Custom Protein Engineering Service for CMTM3

Clone
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OriGene clones in human, mouse for CMTM3 (see all 18)
OriGene ORF clones in mouse, rat for CMTM3
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector (see all 2): CMTM3 (NM_181553)
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for CMTM3
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CMTM3

Cell Line
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CMTM3


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
CKLF3_HUMAN, Q96MX0: Membrane; Multi-pass membrane protein
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
extracellular3
plasma membrane3
nucleus1

Gene Ontology (GO): 3 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005615extracellular space IEA--
GO:0016020membrane ----
GO:0016021integral component of membrane IEA--

Find genes that share ontologies with CMTM3           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for CMTM3 About    
See pathways by source

SuperPathContained pathways About
1B Cell Receptor Signaling Pathway (WikiPathways)
B Cell Receptor Signaling Pathway


1 BioSystems Pathway for CMTM3
    B Cell Receptor Signaling Pathway


    Pathway & Disease-focused RT2 Profiler PCR Array including CMTM3: 
          Chemokines & Receptors in human mouse rat

Interactions:

    Search GeneGlobe Interaction Network for CMTM3

STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

5 Interacting proteins for CMTM3 (Q96MX02, 3 ENSP000003531994) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
MESTQ5EB522, 3, ENSP000002232154MINT-8263027 I2D: score=2 STRING: ENSP00000223215
RABAC1Q9UI142, 3, ENSP000002220084MINT-8267764 I2D: score=2 STRING: ENSP00000222008
BTKQ061873, ENSP000003081764I2D: score=2 STRING: ENSP00000308176
MAPK1P284823, ENSP000002158324I2D: score=2 STRING: ENSP00000215832
BLNKQ8WV283, ENSP000002243374I2D: score=3 STRING: ENSP00000224337
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Gene Ontology (GO): 1 biological process term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006935chemotaxis IEA--

Find genes that share ontologies with CMTM3           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for CMTM3 (CKLF3)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for CMTM3 gene (5 alternative transcripts): 
NM_144601.3  NM_181553.2  NM_001048251.1  NM_181554.1  NM_181555.1  

Unigene Cluster for CMTM3:

CKLF-like MARVEL transmembrane domain containing 3
Hs.298198  [show with all ESTs]
Unigene Representative Sequence: NR_037613
16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000563672 ENST00000424011(uc002epu.3) ENST00000562357 ENST00000562707
ENST00000361909(uc002epv.3) ENST00000460097 ENST00000565666 ENST00000567572(uc002epx.3)
ENST00000564060 ENST00000565922 ENST00000566756(uc002epy.3) ENST00000565003
ENST00000568477 ENST00000566121 ENST00000564247 ENST00000360086
miRNA
Products:
     
Block miRNA regulation of human, mouse, rat CMTM3 using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate CMTM3 (see all 13):
hsa-miR-3163 hsa-miR-3140-3p hsa-miR-622 hsa-miR-3175 hsa-miR-105 hsa-miR-4287 hsa-miR-135b hsa-miR-629*
SwitchGear 3'UTR luciferase reporter plasmidCMTM3 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for CMTM3
Predesigned siRNA for gene silencing in human, mouse, rat CMTM3
Clone
Products:
     
OriGene clones in human, mouse for CMTM3 (see all 18)
OriGene ORF clones in mouse, rat for CMTM3
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector (see all 2): CMTM3 (NM_181553)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for CMTM3
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CMTM3
Primer
Products:
    
OriGene qPCR primer pairs and template standards for CMTM3
OriGene qSTAR qPCR primer pairs in human, mouse for CMTM3
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CMTM3
  QuantiTect SYBR Green Assays in human, mouse, rat CMTM3
  QuantiFast Probe-based Assays in human, mouse, rat CMTM3

Additional mRNA sequence: 

AF479813.1 AK056324.1 AK075075.1 AY166714.1 BC023509.1 BC023591.2 BC036042.1 BC040227.1 
BC047701.1 NR_037613.1 NR_037619.1 

14 DOTS entries:

DT.100030736  DT.419471  DT.100887815  DT.95076933  DT.100887837  DT.97855400  DT.100887822  DT.100887814 
DT.100887832  DT.100887808  DT.100887831  DT.120659287  DT.40305308  DT.95076876 

Selected AceView cDNA sequences (see all 400):

CR613081 BF726556 BG231815 CR625182 AI052494 BE893035 NM_181555 CR589961 
AW196460 AI199561 BC023591 AI221619 BU621695 BC040227 AA722994 CR598427 
BM971810 AA351880 CR606357 BF196680 BC036042 BC047701 BX101320 BQ004224 

GeneLoc Exon Structure

Selected Alternative Splicing Database (ASD) splice patterns (SP) for CMTM3 (see all 9)    About this scheme

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d · 8e · 8f ^ 9
SP1:              -     -     -     -     -     -                 -                                                         
SP2:                                      -     -                 -                                                         
SP3:                                      -     -                                                                           
SP4:                                      -     -                 -                                                         
SP5:                                                              -                                                         


ECgene alternative splicing isoforms for CMTM3

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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CMTM3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TTTGGAGCAT
CMTM3 Expression
About this image

CMTM3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

CMTM3 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.298198

UniProtKB/Swiss-Prot: CKLF3_HUMAN, Q96MX0
Tissue specificity: Expressed in the leukocytes, placenta and testis

    Pathway & Disease-focused RT2 Profiler PCR Array including CMTM3: 
          Chemokines & Receptors in human mouse rat

Primer
Products:
OriGene qPCR primer pairs and template standards for CMTM3
OriGene qSTAR qPCR primer pairs in human, mouse for CMTM3
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CMTM3
QuantiTect SYBR Green Assays in human, mouse, rat CMTM3
QuantiFast Probe-based Assays in human, mouse, rat CMTM3
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CMTM3

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for CMTM3 gene from Selected species (see all 11)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Cmtm31 , 5 CKLF-like MARVEL transmembrane domain containing 31, 5 85.71(n)1
88.46(a)1
  8 (53.04 cM)5
681191  NM_024217.31  NP_077179.11 
 1043405945 
chicken
(Gallus gallus)
Aves CMTM31 CKLF-like MARVEL transmembrane domain containing 3 69.17(n)
70.62(a)
  414829  NM_001001778.2  NP_001001778.2 
lizard
(Anolis carolinensis)
Reptilia CMTM36
CKLF-like MARVEL transmembrane domain containing 3...
52(a)
1 ↔ 1
GL343295.1(75632-97970)
African clawed frog
(Xenopus laevis)
Amphibia Xl.98112 Xenopus laevis transcribed sequence with weak similarity more 71.34(n)    48051914 
zebrafish
(Danio rerio)
Actinopterygii cmtm31 CKLF-like MARVEL transmembrane domain containing 3 65.8(n)
57.79(a)
  445074  NM_001003468.2  NP_001003468.1 


ENSEMBL Gene Tree for CMTM3 (if available)
TreeFam Gene Tree for CMTM3 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for CMTM3 gene
CMTM52  PLP22  
2 SIMAP similar genes for CMTM3 using alignment to 8 protein entries:     CKLF3_HUMAN (see all proteins):
CMTM5    CMTM4

Find genes that share paralogs with CMTM3           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for CMTM3 (see all 227)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 16 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs285218071,2
C,F--66636017(+) AGGTCC/TGGCCA 1 -- us2k11Minor allele frequency- T:0.00CSA 1
rs1387769301,2
--66636071(+) GAGGCA/GGGAAG 1 -- us2k10--------
rs1456683191,2
C--66636384(+) AGGGT-/AAAAAA 2 -- us2k10--------
rs1153148081,2
F--66636430(+) TTGCTT/GCTTCT 2 -- us2k11Minor allele frequency- G:0.01WA 118
rs1166940671,2
F--66636444(+) TCTTCT/GTCTTT 2 -- us2k11Minor allele frequency- G:0.03WA 118
rs1827676451,2
--66636449(+) TTCTTC/TTTTCT 2 -- us2k10--------
rs1865221081,2
--66636532(+) GCAACC/TTCTGC 2 -- us2k10--------
rs1917423991,2
--66636560(+) TTCTCA/CTGCCT 2 -- us2k10--------
rs1412533421,2
--66636606(+) CACCAC/TGCCCA 3 -- us2k10--------
rs1503622031,2
C--66636681(+) CTGACC/TTCAGG 4 -- us2k10--------

HapMap Linkage Disequilibrium report for CMTM3 (66637777 - 66647795 bp)

Structural Variations
     Database of Genomic Variants (DGV) 1 variation for CMTM3:    About this table    
Variant IDTypeSubtypePubMed ID
nsv906786CNV Loss21882294

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing CMTM3
DNA2.0 Custom Variant and Variant Library Synthesis for CMTM3

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 607886    OMIM disorders: --


Find genes that share disorders with CMTM3           About GenesLikeMe

Human Genome Epidemiology (HuGE) Navigator: CMTM3 (1 document)

Export disorders for CMTM3 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for CMTM3 gene, integrated from 10 sources (see all 12):
(articles sorted by number of sources associating them with CMTM3)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Identification and characterization of a novel BASH N terminus-associated protein, BNAS2. (PubMed id 15087455)1, 3 Imamura Y....Kitamura D. (J. Biol. Chem. 2004)
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
  4. Identification of eight genes encoding chemokine-like factor superfamily members 1-8 (CKLFSF1-8) by in silico cloning and experimental validation. (PubMed id 12782130)1, 2 Han W.... Ma D. (Genomics 2003)
  5. CMTM3, located at the critical tumor suppressor locus 16q22.1, is silenced by CpG methylation in carcinomas and inhibits tumor cell growth through inducing apoptosis. (PubMed id 19509237)1, 9 Wang Y....Han W. (Cancer Res. 2009)
  6. A yeast two-hybrid screen reveals that osteopontin associates with MAP1A and MAP1B in addition to other proteins linked to microtubule stability, apoptosis and protein degradation in the human brain. (PubMed id 22779921)1 Long P....Rose S. (Eur. J. Neurosci. 2012)
  7. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
  8. A directed protein interaction network for investigating intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (Sci Signal 2011)
  9. CMTM3 can affect the transcription activity of androgen receptor and inhibit the expression level of PSA in LNCaP cells. (PubMed id 18402773)1 Wang Y....Han W. (Biochem. Biophys. Res. Commun. 2008)
  10. Characterization and expression profile of CMTM3/CKLFSF3. (PubMed id 17002874)1 Zhong J....Han W. (J. Biochem. Mol. Biol. 2006)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 123920 HGNC: 19174 AceView: CKLFSF3 Ensembl:ENSG00000140931 euGenes: HUgn123920
ECgene: CMTM3 H-InvDB: CMTM3

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for CMTM3 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for CMTM3 gene:
Search GeneIP for patents involving CMTM3

GeneCards and IP:
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