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Aliases for CMTM3 Gene

Aliases for CMTM3 Gene

  • CKLF Like MARVEL Transmembrane Domain Containing 3 2 3 5
  • Chemokine-Like Factor Superfamily Member 3 3 4
  • CKLFSF3 3 4
  • CKLF-Like MARVEL Transmembrane Domain-Containing Protein 3 3
  • CKLF-Like MARVEL Transmembrane Domain Containing 3 2
  • Chemokine-Like Factor Superfamily 3 2
  • BNAS2 3

External Ids for CMTM3 Gene

Previous HGNC Symbols for CMTM3 Gene

  • CKLFSF3

Previous GeneCards Identifiers for CMTM3 Gene

  • GC16P065196
  • GC16P052514

Summaries for CMTM3 Gene

Entrez Gene Summary for CMTM3 Gene

  • This gene belongs to the chemokine-like factor gene superfamily, a novel family that is similar to the chemokine and the transmembrane 4 superfamilies of signaling molecules. This gene is one of several chemokine-like factor genes located in a cluster on chromosome 16. Alternatively spliced transcript variants containing different 5' UTRs, but encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for CMTM3 Gene

CMTM3 (CKLF Like MARVEL Transmembrane Domain Containing 3) is a Protein Coding gene. GO annotations related to this gene include cytokine activity. An important paralog of this gene is CMTM5.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CMTM3 Gene

Genomics for CMTM3 Gene

Regulatory Elements for CMTM3 Gene

Enhancers for CMTM3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16F066580 1.1 Ensembl ENCODE 22.4 -22.6 -22585 2.2 CTCF PKNOX1 TEAD4 INSM2 CEBPG RAD21 TEAD3 HIC1 POLR2A ZNF366 BEAN1 CMTM3 CKLF CKLF-CMTM1 TK2 ENSG00000260650
GH16F066638 0.5 ENCODE 13.9 +35.5 35462 1.2 CMTM3 BEAN1 CMTM4 TK2 GC16M066638 PIR56498 GC16M066622
GH16F066695 0.8 ENCODE 12.1 +92.5 92527 2.5 ZNF48 ZNF2 GLIS2 KLF7 SP3 MXD4 REST SMARCA4 GLIS1 MXD3 BEAN1 CMTM3 CA7 CMTM4 GC16M066667
GH16F066399 1.2 Ensembl ENCODE 11.3 -203.8 -203767 1.8 ARID4B DMAP1 FEZF1 ZNF48 SLC30A9 FOS SP5 NFYC MXD4 ZHX2 LINC00920 CDH5 BEAN1 CMTM3 DYNC1LI2 LOC106699570 GC16P066378
GH16F066847 1.2 ENCODE 9.3 +244.6 244561 2.0 BCOR ZMYM3 ZBTB7A ZNF664 ARID1B ZNF121 TFDP1 NCOR1 HDAC2 NFE2 CMTM3 TERB1 B3GNT9 CA7 ENSG00000258122
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around CMTM3 on UCSC Golden Path with GeneCards custom track

Promoters for CMTM3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000146997 1326 2401 HDGF MLX SIN3A ARID4B DMAP1 ZNF48 GLIS2 KLF13 SP3 SP5

Genomic Location for CMTM3 Gene

Chromosome:
16
Start:
66,603,874 bp from pter
End:
66,613,892 bp from pter
Size:
10,019 bases
Orientation:
Plus strand

Genomic View for CMTM3 Gene

Genes around CMTM3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CMTM3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CMTM3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CMTM3 Gene

Proteins for CMTM3 Gene

  • Protein details for CMTM3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96MX0-CKLF3_HUMAN
    Recommended name:
    CKLF-like MARVEL transmembrane domain-containing protein 3
    Protein Accession:
    Q96MX0
    Secondary Accessions:
    • A6NCL9
    • Q8IUU8
    • Q8IWQ6
    • Q8IYE2
    • Q8IZ39
    • Q8IZ59

    Protein attributes for CMTM3 Gene

    Size:
    182 amino acids
    Molecular mass:
    19714 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CMTM3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CMTM3 Gene

Post-translational modifications for CMTM3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CMTM3 Gene

Domains & Families for CMTM3 Gene

Gene Families for CMTM3 Gene

Protein Domains for CMTM3 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q96MX0

UniProtKB/Swiss-Prot:

CKLF3_HUMAN :
  • Contains 1 MARVEL domain.
  • Belongs to the chemokine-like factor family.
Domain:
  • Contains 1 MARVEL domain.
Family:
  • Belongs to the chemokine-like factor family.
genes like me logo Genes that share domains with CMTM3: view

Function for CMTM3 Gene

Gene Ontology (GO) - Molecular Function for CMTM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IEA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with CMTM3: view
genes like me logo Genes that share phenotypes with CMTM3: view

Animal Model Products

miRNA for CMTM3 Gene

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CMTM3 Gene

Localization for CMTM3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CMTM3 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CMTM3 Gene COMPARTMENTS Subcellular localization image for CMTM3 gene
Compartment Confidence
extracellular 3
nucleus 3
plasma membrane 3

Gene Ontology (GO) - Cellular Components for CMTM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IEA --
GO:0005737 cytoplasm IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA,IBA --
GO:0031965 nuclear membrane IEA --
genes like me logo Genes that share ontologies with CMTM3: view

Pathways & Interactions for CMTM3 Gene

SuperPathways for CMTM3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CMTM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006935 chemotaxis IEA --
GO:0050861 positive regulation of B cell receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with CMTM3: view

No data available for Pathways by source and SIGNOR curated interactions for CMTM3 Gene

Transcripts for CMTM3 Gene

Unigene Clusters for CMTM3 Gene

CKLF-like MARVEL transmembrane domain containing 3:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CMTM3 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d · 8e · 8f ^ 9
SP1: - - - - - - -
SP2: - - -
SP3: - -
SP4: - - -
SP5: -
SP6: - - - - -
SP7: - - - -
SP8: - -
SP9: - - - - - - - - - - - - - -

Relevant External Links for CMTM3 Gene

GeneLoc Exon Structure for
CMTM3
ECgene alternative splicing isoforms for
CMTM3

Expression for CMTM3 Gene

mRNA expression in normal human tissues for CMTM3 Gene

mRNA differential expression in normal tissues according to GTEx for CMTM3 Gene

This gene is overexpressed in Whole Blood (x5.3).

Protein differential expression in normal tissues from HIPED for CMTM3 Gene

This gene is overexpressed in Placenta (25.6), Fetal testis (14.8), Ovary (10.9), Testis (7.5), and NK cells (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CMTM3 Gene



Protein tissue co-expression partners for CMTM3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CMTM3 Gene:

CMTM3

SOURCE GeneReport for Unigene cluster for CMTM3 Gene:

Hs.298198

mRNA Expression by UniProt/SwissProt for CMTM3 Gene:

Q96MX0-CKLF3_HUMAN
Tissue specificity: Expressed in the leukocytes, placenta and testis.
genes like me logo Genes that share expression patterns with CMTM3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for CMTM3 Gene

Orthologs for CMTM3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CMTM3 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia CMTM3 34 35
  • 90.17 (n)
chimpanzee
(Pan troglodytes)
Mammalia CMTM3 34 35
  • 89.63 (n)
cow
(Bos Taurus)
Mammalia CMTM3 34 35
  • 89.08 (n)
mouse
(Mus musculus)
Mammalia Cmtm3 34 16 35
  • 85.71 (n)
rat
(Rattus norvegicus)
Mammalia Cmtm3 34
  • 83.7 (n)
oppossum
(Monodelphis domestica)
Mammalia CMTM3 35
  • 61 (a)
OneToOne
chicken
(Gallus gallus)
Aves CMTM3 34 35
  • 69.17 (n)
lizard
(Anolis carolinensis)
Reptilia CMTM3 35
  • 52 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cmtm3 34
  • 63.77 (n)
Str.9768 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.9811 34
zebrafish
(Danio rerio)
Actinopterygii cmtm3 34 35
  • 65.8 (n)
Species where no ortholog for CMTM3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CMTM3 Gene

ENSEMBL:
Gene Tree for CMTM3 (if available)
TreeFam:
Gene Tree for CMTM3 (if available)

Paralogs for CMTM3 Gene

Paralogs for CMTM3 Gene

(2) SIMAP similar genes for CMTM3 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with CMTM3: view

Variants for CMTM3 Gene

Sequence variations from dbSNP and Humsavar for CMTM3 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs111489407 -- 66,608,747(+) GGCCT(A/G)CAGGA intron-variant
rs111492905 -- 66,611,997(+) CTGAC(A/C)CACCC intron-variant
rs111656261 -- 66,611,990(+) TACAG(A/C)CCTGA intron-variant
rs111688701 -- 66,603,290(+) TATTT(-/A)TTTTT intron-variant, upstream-variant-2KB
rs111953008 -- 66,609,642(+) TCATG(A/T)GGGTC intron-variant

Variation tolerance for CMTM3 Gene

Residual Variation Intolerance Score: 43.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.40; 8.81% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CMTM3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CMTM3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CMTM3 Gene

Disorders for CMTM3 Gene

Relevant External Links for CMTM3

Human Genome Epidemiology (HuGE) Navigator
CMTM3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CMTM3

No disorders were found for CMTM3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CMTM3 Gene

Publications for CMTM3 Gene

  1. CMTM3, located at the critical tumor suppressor locus 16q22.1, is silenced by CpG methylation in carcinomas and inhibits tumor cell growth through inducing apoptosis. (PMID: 19509237) Wang Y. … Han W. (Cancer Res. 2009) 3 22 64
  2. Identification and characterization of a novel BASH N terminus-associated protein, BNAS2. (PMID: 15087455) Imamura Y. … Kitamura D. (J. Biol. Chem. 2004) 2 3 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Identification of eight genes encoding chemokine-like factor superfamily members 1-8 (CKLFSF1-8) by in silico cloning and experimental validation. (PMID: 12782130) Han W. … Ma D. (Genomics 2003) 3 4 64

Products for CMTM3 Gene

Sources for CMTM3 Gene

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