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Aliases for CMTM2 Gene

Aliases for CMTM2 Gene

  • CKLF-Like MARVEL Transmembrane Domain Containing 2 2 3
  • CKLFSF2 3 4 6
  • Chemokine-Like Factor Superfamily Member 2 3 4
  • Chemokine-Like Factor Superfamily 2 2 3
  • CKLF-Like MARVEL Transmembrane Domain-Containing Protein 2 3
  • Chemokine-Like Factor Super Family 2 2

External Ids for CMTM2 Gene

Previous Symbols for CMTM2 Gene

  • CKLFSF2

Summaries for CMTM2 Gene

Entrez Gene Summary for CMTM2 Gene

  • This gene belongs to the chemokine-like factor gene superfamily, a novel family that links the chemokine and the transmembrane 4 superfamilies of signaling molecules. The protein encoded by this gene may play an important role in testicular development. [provided by RefSeq, Jul 2008]

GeneCards Summary for CMTM2 Gene

CMTM2 (CKLF-Like MARVEL Transmembrane Domain Containing 2) is a Protein Coding gene. Among its related pathways are Coregulation of Androgen receptor activity. GO annotations related to this gene include cytokine activity.

Gene Wiki entry for CMTM2 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CMTM2 Gene

Genomics for CMTM2 Gene

Genomic Location for CMTM2 Gene

Start:
66,579,448 bp from pter
End:
66,588,275 bp from pter
Size:
8,828 bases
Orientation:
Plus strand

Genomic View for CMTM2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CMTM2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CMTM2 Gene

Regulatory Elements for CMTM2 Gene

Proteins for CMTM2 Gene

  • Protein details for CMTM2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TAZ6-CKLF2_HUMAN
    Recommended name:
    CKLF-like MARVEL transmembrane domain-containing protein 2
    Protein Accession:
    Q8TAZ6
    Secondary Accessions:
    • Q5I2A4
    • Q8N7E5

    Protein attributes for CMTM2 Gene

    Size:
    248 amino acids
    Molecular mass:
    27496 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CMTM2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CMTM2 Gene

Proteomics data for CMTM2 Gene at MOPED

Post-translational modifications for CMTM2 Gene

No Post-translational modifications

Other Protein References for CMTM2 Gene

No data available for DME Specific Peptides for CMTM2 Gene

Domains for CMTM2 Gene

Protein Domains for CMTM2 Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

CKLF2_HUMAN
Domain:
  • Contains 1 MARVEL domain.:
    • Q8TAZ6
Family:
  • Belongs to the chemokine-like factor family.:
    • Q8TAZ6
genes like me logo Genes that share domains with CMTM2: view

No data available for Gene Families for CMTM2 Gene

Function for CMTM2 Gene

Gene Ontology (GO) - Molecular Function for CMTM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IEA --
genes like me logo Genes that share ontologies with CMTM2: view

miRNA for CMTM2 Gene

miRTarBase miRNAs that target CMTM2

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for CMTM2 Gene

Localization for CMTM2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CMTM2 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CMTM2 Gene COMPARTMENTS Subcellular localization image for CMTM2 gene
Compartment Confidence
nucleus 4
extracellular 3
plasma membrane 3
golgi apparatus 2
cytosol 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CMTM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IEA --
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CMTM2: view

Pathways for CMTM2 Gene

genes like me logo Genes that share pathways with CMTM2: view

Pathways by source for CMTM2 Gene

1 BioSystems pathway for CMTM2 Gene

Interacting Proteins for CMTM2 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000268595%0d%0a9606.ENSP00000314151%0d%0a9606.ENSP00000360613%0d%0a9606.ENSP00000363822%0d%0a
Selected Interacting proteins: ENSP00000268595 Q8TAZ6-CKLF2_HUMAN for CMTM2 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for CMTM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006935 chemotaxis IEA --
genes like me logo Genes that share ontologies with CMTM2: view

Transcripts for CMTM2 Gene

Unigene Clusters for CMTM2 Gene

CKLF-like MARVEL transmembrane domain containing 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CMTM2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b
SP1:
SP2: -

Relevant External Links for CMTM2 Gene

GeneLoc Exon Structure for
CMTM2
ECgene alternative splicing isoforms for
CMTM2

Expression for CMTM2 Gene

mRNA expression in normal human tissues for CMTM2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CMTM2 Gene

This gene is overexpressed in Testis (35.7) and Whole Blood (14.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CMTM2 Gene

SOURCE GeneReport for Unigene cluster for CMTM2 Gene Hs.195685

mRNA Expression by UniProt/SwissProt for CMTM2 Gene

Q8TAZ6-CKLF2_HUMAN
Tissue specificity: Highly expressed in testis.
genes like me logo Genes that share expressions with CMTM2: view

Orthologs for CMTM2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CMTM2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CMTM2 36
  • 96.28 (n)
  • 93.49 (a)
CMTM2 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CMTM2 36
  • 75.05 (n)
  • 62.26 (a)
CMTM2 37
  • 49 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CMTM2 37
  • 55 (a)
OneToOne
LOC479694 36
  • 74.92 (n)
  • 64.14 (a)
mouse
(Mus musculus)
Mammalia Cmtm2a 37
  • 47 (a)
OneToMany
Cmtm2b 36
  • 59.2 (n)
  • 44.83 (a)
Cmtm2b 16
Cmtm2b 37
  • 39 (a)
OneToMany
Species with no ortholog for CMTM2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CMTM2 Gene

ENSEMBL:
Gene Tree for CMTM2 (if available)
TreeFam:
Gene Tree for CMTM2 (if available)

Paralogs for CMTM2 Gene

Pseudogenes.org Pseudogenes for CMTM2 Gene

genes like me logo Genes that share paralogs with CMTM2: view

No data available for Paralogs for CMTM2 Gene

Variants for CMTM2 Gene

Sequence variations from dbSNP and Humsavar for CMTM2 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs453615 -- 66,581,850(-) TTTCT(A/G)GGCTG intron-variant
rs2290181 -- 66,580,194(-) TCACC(C/G)CTTAC intron-variant
rs2290182 - 66,580,105(-) AGGAT(A/G)TCTCC intron-variant, missense, reference
rs2290183 -- 66,579,938(-) CCCCC(C/G)ACCCT intron-variant
rs2305312 -- 66,588,308(-) AACTT(C/T)TGCTG downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for CMTM2 Gene

Variant ID Type Subtype PubMed ID
nsv906786 CNV Loss 21882294

Relevant External Links for CMTM2 Gene

HapMap Linkage Disequilibrium report
CMTM2

Disorders for CMTM2 Gene

No disorders were found for CMTM2 Gene.

No data available for UniProtKB/Swiss-Prot for CMTM2 Gene

Publications for CMTM2 Gene

  1. Identification of eight genes encoding chemokine-like factor superfamily members 1-8 (CKLFSF1-8) by in silico cloning and experimental validation. (PMID: 12782130) Han W. … Ma D. (Genomics 2003) 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. CKLFSF2 is highly expressed in testis and can be secreted into the seminiferous tubules. (PMID: 15896670) Shi S. … Ma D. (Int. J. Biochem. Cell Biol. 2005) 3 4
  5. A functional promoter region of the CKLFSF2 gene is located in the last intron/exon region of the upstream CKLFSF1 gene. (PMID: 15778092) Xu M. … Ma D. (Int. J. Biochem. Cell Biol. 2005) 3 23

Products for CMTM2 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Chemokines & Receptors in human,mouse,rat
    • Inflammatory Response & Autoimmunity 384HT in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate CMTM2
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for CMTM2
    • Block miRNA regulation of CMTM2 using miScript Target Protectors

    Sources for CMTM2 Gene

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