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CMTM2 Gene

protein-coding   GIFtS: 50
GCID: GC16P066616

CKLF-Like MARVEL Transmembrane Domain Containing 2

(Previous names: chemokine-like factor super family 2, chemokine-like factor...)
(Previous symbol: CKLFSF2)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
CKLF-Like MARVEL Transmembrane Domain Containing 21 2
CKLFSF21 2 3 5
Chemokine-Like Factor Superfamily 21 2
Chemokine-Like Factor Superfamily Member 22 3
Chemokine-Like Factor Super Family 21
CKLF-Like MARVEL Transmembrane Domain-Containing Protein 22

External Ids:    HGNC: 191731   Entrez Gene: 1462252   Ensembl: ENSG000001409327   OMIM: 6078855   UniProtKB: Q8TAZ63   

Export aliases for CMTM2 gene to outside databases

Previous GC identifers: GC16P065172 GC16P052489


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CMTM2 Gene:
This gene belongs to the chemokine-like factor gene superfamily, a novel family that links the chemokine and the
transmembrane 4 superfamilies of signaling molecules. The protein encoded by this gene may play an important role
in testicular development. (provided by RefSeq, Jul 2008)

GeneCards Summary for CMTM2 Gene:
CMTM2 (CKLF-like MARVEL transmembrane domain containing 2) is a protein-coding gene. GO annotations related to this gene include cytokine activity.

Gene Wiki entry for CMTM2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NC_018927.2  NT_010498.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the CMTM2 gene promoter:
         Oct-B1   LHX3b/Lhx3b   oct-B2   HOXA3   POU3F1   E47   POU2F1   POU2F1a   Hand1   LHX3a/Lhx3a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCMTM2 promoter sequence
   Search Chromatin IP Primers for CMTM2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CMTM2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q21   Ensembl cytogenetic band:  16q21   HGNC cytogenetic band: 16q22.1-q22.3

CMTM2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CMTM2 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P066616:  view genomic region     (about GC identifiers)

Start:
66,613,351 bp from pter      End:
66,622,178 bp from pter
Size:
8,828 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CKLF2_HUMAN, Q8TAZ6 (See protein sequence)
Recommended Name: CKLF-like MARVEL transmembrane domain-containing protein 2  
Size: 248 amino acids; 27496 Da
Secondary accessions: Q5I2A4 Q8N7E5
Alternative splicing: 2 isoforms:  Q8TAZ6-1   Q8TAZ6-2   

Explore the universe of human proteins at neXtProt for CMTM2: NX_Q8TAZ6

Explore proteomics data for CMTM2 at MOPED


See CMTM2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (2 alternative transcripts): 
NP_001186246.1  NP_653274.1  

ENSEMBL proteins: 
 ENSP00000368800   ENSP00000268595   ENSP00000454319  

CMTM2 Human Recombinant Protein Products:

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Cloud-Clone Corp. Proteins for CMTM2

 
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LSBio Antibodies in human, mouse, rat for CMTM2

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Search eBioscience for ELISAs for CMTM2 


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro protein domain:
 IPR008253 Marvel

Graphical View of Domain Structure for InterPro Entry Q8TAZ6

ProtoNet protein and cluster: Q8TAZ6

1 Blocks protein domain: IPB008253 Marvel

UniProtKB/Swiss-Prot: CKLF2_HUMAN, Q8TAZ6
Similarity: Belongs to the chemokine-like factor family
Similarity: Contains 1 MARVEL domain


Find genes that share domains with CMTM2           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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     Gene Ontology (GO): 1 molecular function term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005125cytokine activity IEA--
     
Find genes that share ontologies with CMTM2           About GenesLikeMe


Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CMTM2
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   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CMTM2

miRNA
Products:
    
miRTarBase miRNAs that target CMTM2:
hsa-mir-9-5p (MIRT021338)

Block miRNA regulation of human, mouse, rat CMTM2 using miScript Target Protectors
Search for qRT-PCR Assays for microRNAs that regulate CMTM2
SwitchGear 3'UTR luciferase reporter plasmidCMTM2 3' UTR sequence
Inhib. RNA
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OriGene RNAi products in human, mouse, rat for CMTM2
Predesigned siRNA for gene silencing in human, mouse, rat CMTM2

Gene Editing
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DNA2.0 Custom Protein Engineering Service for CMTM2

Clone
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OriGene ORF clones in mouse, rat for CMTM2
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector (see all 2): CMTM2 (NM_144673)
Sino Biological Human cDNA Clone for CMTM2
DNA2.0 Custom Codon Optimized Gene Synthesis Service for CMTM2
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CMTM2

Cell Line
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CMTM2


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
CKLF2_HUMAN, Q8TAZ6: Membrane; Multi-pass membrane protein
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
nucleus4
extracellular3
plasma membrane3
golgi apparatus2
cytosol1
peroxisome1

Gene Ontology (GO): 4 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005615extracellular space IEA--
GO:0005634nucleus IDA--
GO:0005730NOT nucleolus IDA--
GO:0016021integral component of membrane IEA--

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(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for CMTM2 About    
See pathways by source

SuperPathContained pathways About
1Coregulation of Androgen receptor activity
Coregulation of Androgen receptor activity


1 BioSystems Pathway for CMTM2
    Coregulation of Androgen receptor activity



    Pathway & Disease-focused RT2 Profiler PCR Arrays including CMTM2: 
          Inflammatory Response & Autoimmunity 384HT in human mouse rat
          Chemokines & Receptors in human mouse rat

Interactions:

    Search GeneGlobe Interaction Network for CMTM2

STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

2 Interacting proteins for CMTM2 (Q8TAZ63 ENSP000002685954) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
UBE2AP494593, ENSP000003606134I2D: score=1 STRING: ENSP00000360613
ARENSP000003638224STRING: ENSP00000363822
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Gene Ontology (GO): 1 biological process term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006935chemotaxis IEA--

Find genes that share ontologies with CMTM2           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for CMTM2 (CKLF2)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for CMTM2 gene (2 alternative transcripts): 
NM_001199317.1  NM_144673.2  

Unigene Cluster for CMTM2:

CKLF-like MARVEL transmembrane domain containing 2
Hs.195685  [show with all ESTs]
Unigene Representative Sequence: BM908040
4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000379486(uc010cdu.3) ENST00000268595(uc002ept.3) ENST00000569316
ENST00000532362
miRNA
Products:
     
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Search for qRT-PCR Assays for microRNAs that regulate CMTM2
SwitchGear 3'UTR luciferase reporter plasmidCMTM2 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for CMTM2
Predesigned siRNA for gene silencing in human, mouse, rat CMTM2
Clone
Products:
     
OriGene clones in human, mouse for CMTM2 (see all 6)
OriGene ORF clones in mouse, rat for CMTM2
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector (see all 2): CMTM2 (NM_144673)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for CMTM2
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CMTM2
Primer
Products:
    
OriGene qPCR primer pairs and template standards for CMTM2
OriGene qSTAR qPCR primer pairs in human, mouse for CMTM2
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CMTM2
  QuantiTect SYBR Green Assays in human, mouse, rat CMTM2
  QuantiFast Probe-based Assays in human, mouse, rat CMTM2

Additional mRNA sequence: 

AF479260.1 AK098598.1 AY862139.1 BC025354.1 

1 DOTS entry:

DT.100019639 

Selected AceView cDNA sequences (see all 54):

AA903410 AF479260 BP370428 NM_144673 BC025354 AI201364 AW663435 BX090923 
AK098598 T36109 BI831068 BI830928 BI825591 BI829317 AW663514 BI829585 
AA778552 AW304049 BI825414 BI826066 BI826602 BP371555 BG826826 BI825371 

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for CMTM2    About this scheme

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b
SP1:                              
SP2:        -                     


ECgene alternative splicing isoforms for CMTM2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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CMTM2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: AATCTCCACT
CMTM2 Expression
About this image


CMTM2 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 8) fully expand
 
 Brain (Nervous System)    fully expand to see all 4 entries
         Cerebral Cortex
 
 Testis (Reproductive System)    fully expand to see all 2 entries
         Mature Sertoli Cells Seminiferous Tubules
 
 Ovary (Reproductive System)    fully expand to see all 2 entries
         Ovarian Mesenchymal Stroma Cells Ovary Interstitium
         Oviduct
 
 Bone (Muscoskeletal System)
         Bone Marrow
 
 Trophoblast (Extraembryonic Tissues)
         Trophoblast Cells Trophoblast
CMTM2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

CMTM2 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.195685

UniProtKB/Swiss-Prot: CKLF2_HUMAN, Q8TAZ6
Tissue specificity: Highly expressed in testis

    Pathway & Disease-focused RT2 Profiler PCR Arrays including CMTM2: 
          Inflammatory Response & Autoimmunity 384HT in human mouse rat
          Chemokines & Receptors in human mouse rat

Primer
Products:
OriGene qPCR primer pairs and template standards for CMTM2
OriGene qSTAR qPCR primer pairs in human, mouse for CMTM2
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CMTM2
QuantiTect SYBR Green Assays in human, mouse, rat CMTM2
QuantiFast Probe-based Assays in human, mouse, rat CMTM2
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CMTM2

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of human and mouse.

Orthologs for CMTM2 gene from Selected species (see all 4)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Cmtm2b1 , 5 CKLF-like MARVEL transmembrane domain containing 2B1, 5 59.2(n)1
44.83(a)1
  8 (53.04 cM)5
755021  NM_028524.31  NP_082800.11 
 1043222375 


ENSEMBL Gene Tree for CMTM2 (if available)
TreeFam Gene Tree for CMTM2 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for CMTM2 gene

Find genes that share paralogs with CMTM2           About GenesLikeMe


1 Pseudogenes.org Pseudogene for CMTM2
PGOHUM00000262343


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for CMTM2 (see all 196)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 16 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1450306701,2
C--66613560(+) AGCTCC/AACCTC 4 /Q /P mis11Minor allele frequency- A:0.00NA 4366
rs1421289011,2
F--66613600(+) AAGGAC/TGGTAA 4 D syn11Minor allele frequency- T:0.00NA 4412
rs1876430401,2
C--66613615(+) CCATCA/GGACAA 4 S syn10--------
rs99254431,2
C,F,H--66613691(+) AGCACG/AAAGTG 4 /K /E mis1 ese311Minor allele frequency- A:0.00NS EA NA CSA 5326
rs1115924291,2
C,F--66613724(+) GCTACC/TGGTGG 4 R W mis12Minor allele frequency- T:0.01CSA NA 4522
rs1466373681,2
C,F--66613767(+) CTTGGG/TGCACG 4 G V mis12Minor allele frequency- T:0.00NA EU 5521
rs1122630701,2
C--66613798(+) TTGGTC/GAGCTA 2 -- int10--------
rs2016673121,2
--66613827(+) GGGGGC/TCTTGG 2 -- int10--------
rs22901831,2
C,F,A,H--66613841(-) CCCCCC/GACCCT 2 -- int1 trp39Minor allele frequency- G:0.28EA NS CSA WA NA 2231
rs1413294301,2
C,F--66613989(+) TGAGGC/TTTATC 3 L F mis1 int11Minor allele frequency- T:0.00NA 4550

HapMap Linkage Disequilibrium report for CMTM2 (66613351 - 66622178 bp)

Structural Variations
     Database of Genomic Variants (DGV) 1 variation for CMTM2:    About this table    
Variant IDTypeSubtypePubMed ID
nsv906786CNV Loss21882294

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing CMTM2
DNA2.0 Custom Variant and Variant Library Synthesis for CMTM2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 607885    OMIM disorders: --


Find genes that share disorders with CMTM2           About GenesLikeMe


Export disorders for CMTM2 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for CMTM2 gene, integrated from 10 sources (see all 12):
(articles sorted by number of sources associating them with CMTM2)
    Utopia: connect your pdf to the dynamic
world of online information

  1. CKLFSF2 is highly expressed in testis and can be secreted into the seminiferous tubules. (PubMed id 15896670)1, 2 Shi S.... Ma D. (Int. J. Biochem. Cell Biol. 2005)
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
  4. Identification of eight genes encoding chemokine-like factor superfamily members 1-8 (CKLFSF1-8) by in silico cloning and experimental validation. (PubMed id 12782130)1, 2 Han W.... Ma D. (Genomics 2003)
  5. Expression and localization of CKLFSF2 in human spermatogenesis. (PubMed id 17334588)1, 9 Liu G....Guo Y.L. (Asian J. Androl. 2007)
  6. A functional promoter region of the CKLFSF2 gene is located in the last intron/exon region of the upstream CKLFSF1 gene. (PubMed id 15778092)1, 9 Xu M....Ma D. (amp 2005)
  7. Genome-wide analysis of aberrant DNA methylation for identification of potential biomarkers in colorectal cancer patients. (PubMed id 22901147)1 Fang W.J....Zheng S.S. (Asian Pac. J. Cancer Prev. 2012)
  8. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
  9. Intracellular CMTM2 negatively regulates human immunodeficiency virus type-1 transcription through targeting the transcription factors AP-1 and CREB. (PubMed id 21034562)1 Song H.S....Zhuang H. (Chin. Med. J. 2010)
  10. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 146225 HGNC: 19173 AceView: CKLFSF2 Ensembl:ENSG00000140932 euGenes: HUgn146225
ECgene: CMTM2 H-InvDB: CMTM2

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for CMTM2 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for CMTM2 gene:
Search GeneIP for patents involving CMTM2

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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 OriGene Antibodies for CMTM2   OriGene RNAi products in human, mouse, rat for CMTM2  
 OriGene qPCR primer pairs and template standards for CMTM2   OriGene Protein Over-expression Lysate for CMTM2  
 OriGene Custom Mass Spec   OriGene clones in human, mouse for CMTM2  
 OriGene qSTAR qPCR primer pairs in human, mouse for CMTM2   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
 OriGene ORF clones in mouse, rat for CMTM2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
 OriGene Custom Antibody Services for CMTM2   OriGene Custom Protein Services for CMTM2  

 
 
 Block miRNA regulation of human, mouse, rat CMTM2 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing CMTM2
 DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CMTM2 Predesigned siRNA for gene silencing in human, mouse, rat CMTM2
 QuantiFast Probe-based Assays in human, mouse, rat CMTM2 QuantiTect SYBR Green Assays in human, mouse, rat CMTM2
 PCR Arrays including human, mouse, rat CMTM2 Search Chromatin IP Primers for CMTM2
 Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CMTM2  Search GeneGlobe Interaction Network for CMTM2
 Regulatory tfbs in CMTM2 promoter
 GenScript Custom Purified and Recombinant Proteins Services for CMTM2 GenScript cDNA clones with any tag delivered in your preferred vector for CMTM2
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 CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
 Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
 Plasmid Preparation Custom Peptide Services
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 Search Tocris compounds for CMTM2 (CKLF2)
 Browse Sino Biological Proteins
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 cDNA Clones for CMTM2
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 Protein Production Services
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 Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

 Novus Tissue Slides
 CMTM2 antibodies
 CMTM2 proteins
 CMTM2 lysates
 Antibodies for CMTM2
 See all of Abcam's Antibodies, Kits and Proteins for CMTM2
 Custom Antibody / Protein Production Service
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 Advantages of Rabbit Monoclonal antibodies
 Abcam protocols and scientific support
 Browse ProSpec Recombinant Proteins
 Proteins for CMTM2
 Antibodies for CMTM2
 ELISAs for CMTM2
 CLIAs for CMTM2



 Browse ESI BIO Cell Lines and PureStem Progenitors for CMTM2
 Gene Synthesis
 Protein Engineering
 Variant Library Synthesis
 Codon Optimization
 Protein Production and Purification
 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CMTM2
 SwitchGear 3'UTR luciferase reporter plasmids for CMTM2
 SwitchGear Promoter luciferase reporter plasmids for CMTM2
 Search ThermoFisher Antibodies for CMTM2
 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CMTM2
 inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CMTM2
 inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CMTM2
 LSBio Antibodies in human, mouse, rat for CMTM2
Customized transgenic rodents for:
 Humanization
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 Translational medicine
 Tissue-specific gene expresssion
 Time-controlled gene expresssion
 Browse compounds at ApexBio
 Search Addgene for plasmids for CMTM2
  Search eBioscience for proteins for CMTM2
  Search eBioscience for elisas for CMTM2
  eBioscience FlowRNA Probe Sets
       
GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

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