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Aliases for CMTM2 Gene

Aliases for CMTM2 Gene

  • CKLF-Like MARVEL Transmembrane Domain Containing 2 2 3
  • Chemokine-Like Factor Superfamily Member 2 3 4
  • Chemokine-Like Factor Superfamily 2 2 3
  • CKLFSF2 3 4
  • Chemokine-Like Factor Super Family 2 2

External Ids for CMTM2 Gene

Previous HGNC Symbols for CMTM2 Gene

  • CKLFSF2

Previous GeneCards Identifiers for CMTM2 Gene

  • GC16P065172
  • GC16P052489

Summaries for CMTM2 Gene

Entrez Gene Summary for CMTM2 Gene

  • This gene belongs to the chemokine-like factor gene superfamily, a novel family that links the chemokine and the transmembrane 4 superfamilies of signaling molecules. The protein encoded by this gene may play an important role in testicular development. [provided by RefSeq, Jul 2008]

GeneCards Summary for CMTM2 Gene

CMTM2 (CKLF-Like MARVEL Transmembrane Domain Containing 2) is a Protein Coding gene. Among its related pathways are Coregulation of Androgen receptor activity. GO annotations related to this gene include cytokine activity.

Gene Wiki entry for CMTM2 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CMTM2 Gene

Genomics for CMTM2 Gene

Regulatory Elements for CMTM2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CMTM2 Gene

Chromosome:
16
Start:
66,579,448 bp from pter
End:
66,588,275 bp from pter
Size:
8,828 bases
Orientation:
Plus strand

Genomic View for CMTM2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CMTM2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CMTM2 Gene

Proteins for CMTM2 Gene

  • Protein details for CMTM2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TAZ6-CKLF2_HUMAN
    Recommended name:
    CKLF-like MARVEL transmembrane domain-containing protein 2
    Protein Accession:
    Q8TAZ6
    Secondary Accessions:
    • Q5I2A4
    • Q8N7E5

    Protein attributes for CMTM2 Gene

    Size:
    248 amino acids
    Molecular mass:
    27496 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CMTM2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CMTM2 Gene

Proteomics data for CMTM2 Gene at MOPED

Post-translational modifications for CMTM2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CMTM2 Gene

No data available for DME Specific Peptides for CMTM2 Gene

Domains & Families for CMTM2 Gene

Gene Families for CMTM2 Gene

Protein Domains for CMTM2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for CMTM2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TAZ6

UniProtKB/Swiss-Prot:

CKLF2_HUMAN :
  • Contains 1 MARVEL domain.
  • Belongs to the chemokine-like factor family.
Domain:
  • Contains 1 MARVEL domain.
Family:
  • Belongs to the chemokine-like factor family.
genes like me logo Genes that share domains with CMTM2: view

Function for CMTM2 Gene

Gene Ontology (GO) - Molecular Function for CMTM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IEA --
genes like me logo Genes that share ontologies with CMTM2: view

Phenotypes for CMTM2 Gene

GenomeRNAi human phenotypes for CMTM2:
genes like me logo Genes that share phenotypes with CMTM2: view

Animal Model Products

CRISPR Products

miRNA for CMTM2 Gene

miRTarBase miRNAs that target CMTM2

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CMTM2

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for CMTM2 Gene

Localization for CMTM2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CMTM2 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CMTM2 Gene COMPARTMENTS Subcellular localization image for CMTM2 gene
Compartment Confidence
nucleus 4
extracellular 3
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for CMTM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IEA --
GO:0005654 nucleoplasm IDA --
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CMTM2: view

Pathways & Interactions for CMTM2 Gene

genes like me logo Genes that share pathways with CMTM2: view

Pathways by source for CMTM2 Gene

1 BioSystems pathway for CMTM2 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Chemokines & Receptors in human,mouse,rat
    • Inflammatory Response & Autoimmunity 384HT in human,mouse,rat

Interacting Proteins for CMTM2 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000268595%0d%0a9606.ENSP00000314151%0d%0a9606.ENSP00000360613%0d%0a9606.ENSP00000363822%0d%0a
Selected Interacting proteins: Q8TAZ6-CKLF2_HUMAN ENSP00000268595 for CMTM2 Gene via I2D STRING

Gene Ontology (GO) - Biological Process for CMTM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006935 chemotaxis IEA --
genes like me logo Genes that share ontologies with CMTM2: view

No data available for SIGNOR curated interactions for CMTM2 Gene

Drugs & Compounds for CMTM2 Gene

No Compound Related Data Available

Transcripts for CMTM2 Gene

Unigene Clusters for CMTM2 Gene

CKLF-like MARVEL transmembrane domain containing 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CMTM2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CMTM2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b
SP1:
SP2: -

Relevant External Links for CMTM2 Gene

GeneLoc Exon Structure for
CMTM2
ECgene alternative splicing isoforms for
CMTM2

Expression for CMTM2 Gene

mRNA expression in normal human tissues for CMTM2 Gene

mRNA differential expression in normal tissues according to GTEx for CMTM2 Gene

This gene is overexpressed in Testis (x35.7) and Whole Blood (x14.9).

Protein differential expression in normal tissues from HIPED for CMTM2 Gene

This gene is overexpressed in Monocytes (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CMTM2 Gene



SOURCE GeneReport for Unigene cluster for CMTM2 Gene Hs.195685

mRNA Expression by UniProt/SwissProt for CMTM2 Gene

Q8TAZ6-CKLF2_HUMAN
Tissue specificity: Highly expressed in testis.
genes like me logo Genes that share expression patterns with CMTM2: view

Protein tissue co-expression partners for CMTM2 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for CMTM2 Gene

Orthologs for CMTM2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CMTM2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CMTM2 35
  • 75.05 (n)
  • 62.26 (a)
CMTM2 36
  • 49 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC479694 35
  • 74.92 (n)
  • 64.14 (a)
CMTM2 36
  • 55 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cmtm2b 35
  • 59.2 (n)
  • 44.83 (a)
Cmtm2b 16
Cmtm2a 36
  • 47 (a)
OneToMany
Cmtm2b 36
  • 39 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia CMTM2 35
  • 96.28 (n)
  • 93.49 (a)
CMTM2 36
  • 98 (a)
OneToOne
Species with no ortholog for CMTM2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CMTM2 Gene

ENSEMBL:
Gene Tree for CMTM2 (if available)
TreeFam:
Gene Tree for CMTM2 (if available)

Paralogs for CMTM2 Gene

Pseudogenes.org Pseudogenes for CMTM2 Gene

genes like me logo Genes that share paralogs with CMTM2: view

No data available for Paralogs for CMTM2 Gene

Variants for CMTM2 Gene

Sequence variations from dbSNP and Humsavar for CMTM2 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs453615 -- 66,581,850(-) TTTCT(A/G)GGCTG intron-variant
rs2290181 -- 66,580,194(-) TCACC(C/G)CTTAC intron-variant
rs2290182 - 66,580,105(-) AGGAT(A/G)TCTCC intron-variant, missense, reference
rs2290183 -- 66,579,938(-) CCCCC(A/C/G/T)ACCCT intron-variant
rs2305312 -- 66,588,308(-) AACTT(C/T)TGCTG downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for CMTM2 Gene

Variant ID Type Subtype PubMed ID
nsv906786 CNV Loss 21882294

Variation tolerance for CMTM2 Gene

Residual Variation Intolerance Score: 45.67% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.59; 72.40% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CMTM2 Gene

HapMap Linkage Disequilibrium report
CMTM2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CMTM2 Gene

Disorders for CMTM2 Gene

Relevant External Links for CMTM2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CMTM2
genes like me logo Genes that share disorders with CMTM2: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CMTM2 Gene

Publications for CMTM2 Gene

  1. Expression and localization of CKLFSF2 in human spermatogenesis. (PMID: 17334588) Liu G. … Guo Y.L. (Asian J. Androl. 2007) 23 67
  2. A functional promoter region of the CKLFSF2 gene is located in the last intron/exon region of the upstream CKLFSF1 gene. (PMID: 15778092) Xu M. … Ma D. (Int. J. Biochem. Cell Biol. 2005) 23 67
  3. Genome-wide analysis of aberrant DNA methylation for identification of potential biomarkers in colorectal cancer patients. (PMID: 22901147) Fang W.J. … Zheng S.S. (Asian Pac. J. Cancer Prev. 2012) 67
  4. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 67
  5. Intracellular CMTM2 negatively regulates human immunodeficiency virus type-1 transcription through targeting the transcription factors AP-1 and CREB. (PMID: 21034562) Song H.S. … Zhuang H. (Chin. Med. J. 2010) 67

Products for CMTM2 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Chemokines & Receptors in human,mouse,rat
    • Inflammatory Response & Autoimmunity 384HT in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate CMTM2
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for CMTM2
    • Block miRNA regulation of CMTM2 using miScript Target Protectors

    Sources for CMTM2 Gene

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