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Aliases for CMTM1 Gene

Aliases for CMTM1 Gene

  • CKLF-Like MARVEL Transmembrane Domain Containing 1 2 3
  • CKLFSF1 3 4 6
  • Chemokine-Like Factor Superfamily Member 1 3 4
  • Chemokine-Like Factor Super Family 1 2 3
  • Chemokine-Like Factor Superfamily 1 2 3
  • CKLF-Like MARVEL Transmembrane Domain-Containing Protein 1 3
  • Chemokine-Like Factor-Like Protein CKLFH1 3
  • CKLFH1 3
  • CKLFH 3

External Ids for CMTM1 Gene

Previous HGNC Symbols for CMTM1 Gene

  • CKLFSF1

Previous GeneCards Identifiers for CMTM1 Gene

  • GC16P065157
  • GC16P066600
  • GC16P052476

Summaries for CMTM1 Gene

Entrez Gene Summary for CMTM1 Gene

  • This gene belongs to the chemokine-like factor gene superfamily, a novel family that is similar to the chemokine and the transmembrane 4 superfamilies of signaling molecules. The protein encoded by this gene may play an important role in testicular development. Alternatively spliced transcript variants encoding different isoforms have been identified. Naturally occurring read-through transcription occurs between this locus and the neighboring locus CKLF (chemokine-like factor).[provided by RefSeq, Feb 2011]

GeneCards Summary for CMTM1 Gene

CMTM1 (CKLF-Like MARVEL Transmembrane Domain Containing 1) is a Protein Coding gene. GO annotations related to this gene include cytokine activity. An important paralog of this gene is CKLF.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CMTM1 Gene

Genomics for CMTM1 Gene

Regulatory Elements for CMTM1 Gene

Transcription factor binding sites by QIAGEN in the CMTM1 gene promoter:

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CMTM1 Gene

Start:
66,566,391 bp from pter
End:
66,579,137 bp from pter
Size:
12,747 bases
Orientation:
Plus strand

Genomic View for CMTM1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CMTM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CMTM1 Gene

Proteins for CMTM1 Gene

neXtProt entry for CMTM1 Gene

Proteomics data for CMTM1 Gene at MOPED

Post-translational modifications for CMTM1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CMTM1 Gene

Domains for CMTM1 Gene

Protein Domains for CMTM1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CMTM1 Gene

Graphical View of Domain Structure for InterPro Entry

Q8IZ96

UniProtKB/Swiss-Prot:

CKLF1_HUMAN :
  • Q8IZ96
Domain:
  • Contains 1 MARVEL domain.
Family:
  • Belongs to the chemokine-like factor family.
genes like me logo Genes that share domains with CMTM1: view

No data available for Gene Families for CMTM1 Gene

Function for CMTM1 Gene

Gene Ontology (GO) - Molecular Function for CMTM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IEA --
genes like me logo Genes that share ontologies with CMTM1: view

Animal Model Products

CRISPR Products

miRNA for CMTM1 Gene

miRTarBase miRNAs that target CMTM1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CMTM1

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for CMTM1 Gene

Localization for CMTM1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CMTM1 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CMTM1 Gene COMPARTMENTS Subcellular localization image for CMTM1 gene
Compartment Confidence
extracellular 3
plasma membrane 3
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CMTM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IEA --
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CMTM1: view

Pathways for CMTM1 Gene

SuperPathways for CMTM1 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Chemokines & Receptors in human,mouse,rat
    • Inflammatory Response & Autoimmunity 384HT in human,mouse,rat

Interacting Proteins for CMTM1 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000368814%0d%0a9606.ENSP00000358081%0d%0a9606.ENSP00000224337%0d%0a
Selected Interacting proteins: ENSP00000368814 for CMTM1 Gene via STRING

Gene Ontology (GO) - Biological Process for CMTM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006935 chemotaxis IEA --
genes like me logo Genes that share ontologies with CMTM1: view

No data available for Pathways by source for CMTM1 Gene

Transcripts for CMTM1 Gene

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CMTM1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for CMTM1
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CMTM1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b ^ 11a · 11b
SP1: - - - - -
SP2: - - -
SP3: - - - -
SP4: - -
SP5: - - -
SP6: - -
SP7: - - - -
SP8: - - - - -
SP9: -
SP10: - - -
SP11: - - -
SP12: - - -
SP13: - - - - - - -
SP14: - - - - - - - -
SP15: - - - - - - - - - -
SP16: - - - - - -
SP17:
SP18: - - - - - - - - - - - - - - -

Relevant External Links for CMTM1 Gene

GeneLoc Exon Structure for
CMTM1
ECgene alternative splicing isoforms for
CMTM1

Expression for CMTM1 Gene

mRNA expression in normal human tissues for CMTM1 Gene

mRNA differential expression in normal tissues according to GTEx for CMTM1 Gene

This gene is overexpressed in Testis (28.0) and Whole Blood (7.1).

SOURCE GeneReport for Unigene cluster for CMTM1 Gene Hs.698621

mRNA Expression by UniProt/SwissProt for CMTM1 Gene

Q8IZ96-CKLF1_HUMAN
Tissue specificity: Highly expressed in testis.
genes like me logo Genes that share expressions with CMTM1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein expression for CMTM1 Gene

Orthologs for CMTM1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CMTM1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 99 (a)
OneToMany
LOC100610567 35
  • 99.18 (n)
  • 98.95 (a)
cow
(Bos Taurus)
Mammalia LOC525286 35
  • 74.26 (n)
  • 60.4 (a)
dog
(Canis familiaris)
Mammalia CMTM1 35
  • 68.45 (n)
  • 56.79 (a)
CMTM1 36
  • 30 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Cmtm1 16
Cmtm1 36
  • 23 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 39 (a)
OneToMany
Species with no ortholog for CMTM1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CMTM1 Gene

ENSEMBL:
Gene Tree for CMTM1 (if available)
TreeFam:
Gene Tree for CMTM1 (if available)

Paralogs for CMTM1 Gene

Paralogs for CMTM1 Gene

Selected SIMAP similar genes for CMTM1 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with CMTM1: view

Variants for CMTM1 Gene

Sequence variations from dbSNP and Humsavar for CMTM1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
VAR_053039 -

Structural Variations from Database of Genomic Variants (DGV) for CMTM1 Gene

Variant ID Type Subtype PubMed ID
nsv906785 CNV Loss 21882294
nsv906786 CNV Loss 21882294
nsv906787 CNV Gain 21882294

Relevant External Links for CMTM1 Gene

HapMap Linkage Disequilibrium report
CMTM1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CMTM1 Gene

Disorders for CMTM1 Gene

Relevant External Links for CMTM1

Human Genome Epidemiology (HuGE) Navigator
CMTM1
genes like me logo Genes that share disorders with CMTM1: view

No data available for UniProtKB/Swiss-Prot for CMTM1 Gene

Publications for CMTM1 Gene

  1. Identification of eight genes encoding chemokine-like factor superfamily members 1-8 (CKLFSF1-8) by in silico cloning and experimental validation. (PMID: 12782130) Han W. … Ma D. (Genomics 2003) 2 3 4
  2. Molecular cloning and characterization of chemokine-like factor super family member 1 (CKLFSF1), a novel human gene with at least 23 alternative splicing isoforms in testis tissue. (PMID: 15147728) Wang L. … Ma D. (Int. J. Biochem. Cell Biol. 2004) 3 4 23
  3. A functional promoter region of the CKLFSF2 gene is located in the last intron/exon region of the upstream CKLFSF1 gene. (PMID: 15778092) Xu M. … Ma D. (Int. J. Biochem. Cell Biol. 2005) 3 23
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Last intron of the chemokine-like factor gene contains a putative promoter for the downstream CKLF super family member 1 gene. (PMID: 14672709) Xu M. … Ma D. (Biochem. Biophys. Res. Commun. 2004) 23

Products for CMTM1 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Chemokines & Receptors in human,mouse,rat
    • Inflammatory Response & Autoimmunity 384HT in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate CMTM1
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for CMTM1
    • Block miRNA regulation of CMTM1 using miScript Target Protectors

    Sources for CMTM1 Gene

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