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Aliases for CMTM1 Gene

Aliases for CMTM1 Gene

  • CKLF Like MARVEL Transmembrane Domain Containing 1 2 3 5
  • Chemokine-Like Factor Superfamily Member 1 3 4
  • Chemokine-Like Factor Super Family 1 2 3
  • Chemokine-Like Factor Superfamily 1 2 3
  • CKLFSF1 3 4
  • CKLF-Like MARVEL Transmembrane Domain-Containing Protein 1 3
  • CKLF-Like MARVEL Transmembrane Domain Containing 1 2
  • Chemokine-Like Factor-Like Protein CKLFH1 3
  • CKLFH1 3
  • CKLFH 3

External Ids for CMTM1 Gene

Previous HGNC Symbols for CMTM1 Gene


Previous GeneCards Identifiers for CMTM1 Gene

  • GC16P065157
  • GC16P066600
  • GC16P052476

Summaries for CMTM1 Gene

Entrez Gene Summary for CMTM1 Gene

  • This gene belongs to the chemokine-like factor gene superfamily, a novel family that is similar to the chemokine and the transmembrane 4 superfamilies of signaling molecules. The protein encoded by this gene may play an important role in testicular development. Alternatively spliced transcript variants encoding different isoforms have been identified. Naturally occurring read-through transcription occurs between this locus and the neighboring locus CKLF (chemokine-like factor).[provided by RefSeq, Feb 2011]

GeneCards Summary for CMTM1 Gene

CMTM1 (CKLF Like MARVEL Transmembrane Domain Containing 1) is a Protein Coding gene. GO annotations related to this gene include cytokine activity. An important paralog of this gene is CKLF-CMTM1.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CMTM1 Gene

Genomics for CMTM1 Gene

Regulatory Elements for CMTM1 Gene

Enhancers for CMTM1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16F066519 1.4 FANTOM5 ENCODE 1.3 -43.0 -42993 8.1 PKNOX1 ATF1 WRNIP1 SIN3A ZNF766 GATA2 ZNF143 ZNF548 JUNB TBX21 TK2 CKLF BEAN1 CKLF-CMTM1 E2F4 ENSG00000260465 ZDHHC1 LINC00920 CMTM1 ENSG00000260851
GH16F066568 1.3 Ensembl ENCODE 0.8 +3.1 3126 2.5 HDGF CREB3L1 ARID4B DMAP1 ZNF766 ZNF207 FOS KLF13 ZNF263 SP3 BEAN1 E2F4 ENSG00000260465 FBXL8 KIAA0895L ZDHHC1 CMTM1 CMTM2
GH16F066161 0.4 FANTOM5 2.3 -404.3 -404261 0.4 ZBTB11 CMTM1 CMTM2 LOC105371316 GC16M066229
GH16F066579 0.5 ENCODE 0.4 +12.7 12702 0.2 RNF2 POLR2A EZH2 CMTM2 CMTM1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CMTM1 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the CMTM1 gene promoter:

Genomic Location for CMTM1 Gene

66,566,391 bp from pter
66,579,137 bp from pter
12,747 bases
Plus strand

Genomic View for CMTM1 Gene

Genes around CMTM1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CMTM1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CMTM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CMTM1 Gene

Proteins for CMTM1 Gene

neXtProt entry for CMTM1 Gene

Post-translational modifications for CMTM1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CMTM1 Gene

Domains & Families for CMTM1 Gene

Gene Families for CMTM1 Gene

Protein Domains for CMTM1 Gene


Suggested Antigen Peptide Sequences for CMTM1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 MARVEL domain.
  • Belongs to the chemokine-like factor family.
  • Contains 1 MARVEL domain.
  • Belongs to the chemokine-like factor family.
genes like me logo Genes that share domains with CMTM1: view

Function for CMTM1 Gene

Gene Ontology (GO) - Molecular Function for CMTM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IEA --
genes like me logo Genes that share ontologies with CMTM1: view

Phenotypes for CMTM1 Gene

GenomeRNAi human phenotypes for CMTM1:
genes like me logo Genes that share phenotypes with CMTM1: view

Animal Model Products

miRNA for CMTM1 Gene

miRTarBase miRNAs that target CMTM1

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CMTM1 Gene

Localization for CMTM1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CMTM1 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CMTM1 gene
Compartment Confidence
plasma membrane 3
extracellular 3
nucleus 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for CMTM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA,IBA --
genes like me logo Genes that share ontologies with CMTM1: view

Pathways & Interactions for CMTM1 Gene

SuperPathways for CMTM1 Gene

No Data Available

Interacting Proteins for CMTM1 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: Q8IZ96-CKLF1_HUMAN ENSP00000368814 for CMTM1 Gene via IID STRING

Gene Ontology (GO) - Biological Process for CMTM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006935 chemotaxis IEA --
genes like me logo Genes that share ontologies with CMTM1: view

No data available for Pathways by source and SIGNOR curated interactions for CMTM1 Gene

Transcripts for CMTM1 Gene

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CMTM1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b ^ 11a · 11b
SP1: - - - - -
SP2: - - -
SP3: - - - -
SP4: - -
SP5: - - -
SP6: - -
SP7: - - - -
SP8: - - - - -
SP9: -
SP10: - - -
SP11: - - -
SP12: - - -
SP13: - - - - - - -
SP14: - - - - - - - -
SP15: - - - - - - - - - -
SP16: - - - - - -
SP18: - - - - - - - - - - - - - - -

Relevant External Links for CMTM1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CMTM1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CMTM1 Gene

mRNA differential expression in normal tissues according to GTEx for CMTM1 Gene

This gene is overexpressed in Testis (x28.0) and Whole Blood (x7.1).

NURSA nuclear receptor signaling pathways regulating expression of CMTM1 Gene:


SOURCE GeneReport for Unigene cluster for CMTM1 Gene:


mRNA Expression by UniProt/SwissProt for CMTM1 Gene:

Tissue specificity: Highly expressed in testis.
genes like me logo Genes that share expression patterns with CMTM1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for CMTM1 Gene

Orthologs for CMTM1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CMTM1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC100610567 34
  • 99.18 (n)
-- 35
  • 99 (a)
(Bos Taurus)
Mammalia LOC525286 34
  • 74.26 (n)
(Canis familiaris)
Mammalia CMTM1 34 35
  • 68.45 (n)
(Monodelphis domestica)
Mammalia -- 35
  • 39 (a)
(Mus musculus)
Mammalia Cmtm1 35
  • 23 (a)
Species where no ortholog for CMTM1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CMTM1 Gene

Gene Tree for CMTM1 (if available)
Gene Tree for CMTM1 (if available)

Paralogs for CMTM1 Gene

Paralogs for CMTM1 Gene

(2) SIMAP similar genes for CMTM1 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with CMTM1: view

Variants for CMTM1 Gene

Sequence variations from dbSNP and Humsavar for CMTM1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs10500537 -- 66,569,368(+) CTAGG(C/T)GAAAC intron-variant
rs10500538 -- 66,574,286(+) AACAC(A/G)GCCAT intron-variant
rs10716244 -- 66,576,786(+) GGATA(-/G)GCCCC intron-variant
rs111288391 -- 66,576,606(+) AATTT(C/T)CAGAG intron-variant
rs111552835 -- 66,577,687(+) CAAGC(A/G)GGGCA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CMTM1 Gene

Variant ID Type Subtype PubMed ID
dgv123n111 CNV duplication 26073780
nsv472890 CNV novel sequence insertion 20440878
esv3638871 CNV gain 21293372

Variation tolerance for CMTM1 Gene

Residual Variation Intolerance Score: 46.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.95; 19.56% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CMTM1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CMTM1 Gene

Disorders for CMTM1 Gene

Relevant External Links for CMTM1

Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CMTM1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CMTM1 Gene

Publications for CMTM1 Gene

  1. Molecular cloning and characterization of chemokine-like factor super family member 1 (CKLFSF1), a novel human gene with at least 23 alternative splicing isoforms in testis tissue. (PMID: 15147728) Wang L. … Ma D. (Int. J. Biochem. Cell Biol. 2004) 3 4 22 64
  2. Identification of eight genes encoding chemokine-like factor superfamily members 1-8 (CKLFSF1-8) by in silico cloning and experimental validation. (PMID: 12782130) Han W. … Ma D. (Genomics 2003) 2 3 4 64
  3. A functional promoter region of the CKLFSF2 gene is located in the last intron/exon region of the upstream CKLFSF1 gene. (PMID: 15778092) Xu M. … Ma D. (Int. J. Biochem. Cell Biol. 2005) 3 22 64
  4. Systematic investigation of CMTM family genes suggests relevance to glioblastoma pathogenesis and CMTM1 and CMTM3 as priority targets. (PMID: 25931111) Delic S. … Riemenschneider M.J. (Genes Chromosomes Cancer 2015) 3 64
  5. CMTM1_v17 is a novel potential therapeutic target in breast cancer. (PMID: 25175386) Wang J. … Wang L. (Oncol. Rep. 2014) 3 64

Products for CMTM1 Gene

Sources for CMTM1 Gene

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