Aliases for CMPK2 Gene
External Ids for CMPK2 Gene
Previous GeneCards Identifiers for CMPK2 Gene
This gene encodes one of the enzymes in the nucleotide synthesis salvage pathway that may participate in terminal differentiation of monocytic cells. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]
GeneCards Summary for CMPK2 Gene
CMPK2 (Cytidine Monophosphate (UMP-CMP) Kinase 2, Mitochondrial) is a Protein Coding gene. Among its related pathways are Metabolism and Pyrimidine metabolism (KEGG). GO annotations related to this gene include nucleoside diphosphate kinase activity and uridylate kinase activity.
UniProtKB/Swiss-Prot for CMPK2 Gene
May participate in dUTP and dCTP synthesis in mitochondria. Is able to phosphorylate dUMP, dCMP, CMP, UMP and monophosphates of the pyrimidine nucleoside analogs ddC, dFdC, araC, BVDU and FdUrd with ATP as phosphate donor. Efficacy is highest for dUMP followed by dCMP; CMP and UMP are poor substrates. May be involved in mtDNA depletion caused by long term treatment with ddC or other pyrimidine analogs. Also displays broad nucleoside diphosphate kinase activity.