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Aliases for CMPK2 Gene

Aliases for CMPK2 Gene

  • Cytidine/Uridine Monophosphate Kinase 2 2 3
  • Cytidine Monophosphate (UMP-CMP) Kinase 2, Mitochondrial 2 3 5
  • Nucleoside-Diphosphate Kinase 2 3 4
  • Cytidylate Kinase 2 2 3
  • UMP/CMP Kinase 2 3
  • Thymidylate Kinase Family LPS-Inducible Member 3
  • Thymidine Monophosphate Kinase 2 3
  • Mitochondrial UMP-CMP Kinase 3
  • EC 2.7.4.14 4
  • EC 2.7.4.6 4
  • UMP-CMPK2 3
  • TMPK2 3
  • TYKi 3
  • NDK 3

External Ids for CMPK2 Gene

Previous GeneCards Identifiers for CMPK2 Gene

  • GC02M006897
  • GC02M006980

Summaries for CMPK2 Gene

Entrez Gene Summary for CMPK2 Gene

  • This gene encodes one of the enzymes in the nucleotide synthesis salvage pathway that may participate in terminal differentiation of monocytic cells. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]

GeneCards Summary for CMPK2 Gene

CMPK2 (Cytidine/Uridine Monophosphate Kinase 2) is a Protein Coding gene. Among its related pathways are Metabolism and superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis. GO annotations related to this gene include nucleoside diphosphate kinase activity and uridylate kinase activity.

UniProtKB/Swiss-Prot for CMPK2 Gene

  • May participate in dUTP and dCTP synthesis in mitochondria. Is able to phosphorylate dUMP, dCMP, CMP, UMP and monophosphates of the pyrimidine nucleoside analogs ddC, dFdC, araC, BVDU and FdUrd with ATP as phosphate donor. Efficacy is highest for dUMP followed by dCMP; CMP and UMP are poor substrates. May be involved in mtDNA depletion caused by long term treatment with ddC or other pyrimidine analogs. Also displays broad nucleoside diphosphate kinase activity.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CMPK2 Gene

Genomics for CMPK2 Gene

Regulatory Elements for CMPK2 Gene

Promoters for CMPK2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CMPK2 on UCSC Golden Path with GeneCards custom track

Genomic Location for CMPK2 Gene

Chromosome:
2
Start:
6,840,417 bp from pter
End:
6,866,635 bp from pter
Size:
26,219 bases
Orientation:
Minus strand

Genomic View for CMPK2 Gene

Genes around CMPK2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CMPK2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CMPK2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CMPK2 Gene

Proteins for CMPK2 Gene

  • Protein details for CMPK2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5EBM0-CMPK2_HUMAN
    Recommended name:
    UMP-CMP kinase 2, mitochondrial
    Protein Accession:
    Q5EBM0
    Secondary Accessions:
    • A2RUB0
    • A5D8T2
    • B7ZM18
    • Q6ZRU2
    • Q96AL8

    Protein attributes for CMPK2 Gene

    Size:
    449 amino acids
    Molecular mass:
    49448 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CMPK2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CMPK2 Gene

Proteomics data for CMPK2 Gene at MOPED

Post-translational modifications for CMPK2 Gene

  • Ubiquitination at Lys 245, Lys 277, Lys 282, Lys 393, and Lys 409
  • Modification sites at PhosphoSitePlus

Other Protein References for CMPK2 Gene

Antibody Products

No data available for DME Specific Peptides for CMPK2 Gene

Domains & Families for CMPK2 Gene

Protein Domains for CMPK2 Gene

Suggested Antigen Peptide Sequences for CMPK2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5EBM0

UniProtKB/Swiss-Prot:

CMPK2_HUMAN :
  • Belongs to the thymidylate kinase family.
Family:
  • Belongs to the thymidylate kinase family.
genes like me logo Genes that share domains with CMPK2: view

No data available for Gene Families for CMPK2 Gene

Function for CMPK2 Gene

Molecular function for CMPK2 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=3.09 mM for CMP; KM=6.3 mM for UMP; KM=1.31 mM for dCMP; KM=0.1 mM for dUMP; Vmax=1.64 umol/min/mg enzyme towards CMP; Vmax=0.19 umol/min/mg enzyme towards UMP; Vmax=1.77 umol/min/mg enzyme towards dCMP; Vmax=0.48 umol/min/mg enzyme towards dUMP;
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + (d)CMP = ADP + (d)CDP.
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + nucleoside diphosphate = ADP + nucleoside triphosphate.
UniProtKB/Swiss-Prot Function:
May participate in dUTP and dCTP synthesis in mitochondria. Is able to phosphorylate dUMP, dCMP, CMP, UMP and monophosphates of the pyrimidine nucleoside analogs ddC, dFdC, araC, BVDU and FdUrd with ATP as phosphate donor. Efficacy is highest for dUMP followed by dCMP; CMP and UMP are poor substrates. May be involved in mtDNA depletion caused by long term treatment with ddC or other pyrimidine analogs. Also displays broad nucleoside diphosphate kinase activity.

Enzyme Numbers (IUBMB) for CMPK2 Gene

Gene Ontology (GO) - Molecular Function for CMPK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
GO:0009041 uridylate kinase activity IEA --
genes like me logo Genes that share ontologies with CMPK2: view

Phenotypes for CMPK2 Gene

GenomeRNAi human phenotypes for CMPK2:
genes like me logo Genes that share phenotypes with CMPK2: view

Animal Model Products

miRNA for CMPK2 Gene

miRTarBase miRNAs that target CMPK2

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CMPK2 Gene

Localization for CMPK2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CMPK2 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CMPK2 Gene COMPARTMENTS Subcellular localization image for CMPK2 gene
Compartment Confidence
mitochondrion 5
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for CMPK2 Gene

Pathways & Interactions for CMPK2 Gene

genes like me logo Genes that share pathways with CMPK2: view

Interacting Proteins for CMPK2 Gene

Gene Ontology (GO) - Biological Process for CMPK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006227 dUDP biosynthetic process IBA --
GO:0006233 dTDP biosynthetic process IBA --
GO:0006235 dTTP biosynthetic process IBA --
GO:0071222 cellular response to lipopolysaccharide IEA --
genes like me logo Genes that share ontologies with CMPK2: view

No data available for SIGNOR curated interactions for CMPK2 Gene

Drugs & Compounds for CMPK2 Gene

(6) Drugs for CMPK2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
Ergocalciferol Approved Nutra 923
CDP Experimental Pharma 0
dCMP Experimental Pharma 0
Uridine-5'-Diphosphate Experimental Pharma 0

(3) Additional Compounds for CMPK2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
Cytidine monophosphate
  • 5'-CMP
  • 5-Cytidylate
  • 5-Cytidylic acid
  • CMP
  • Cytidine 5'-monophosphate
63-37-6
dcdp
  • 2'-Deoxy-Cytidine 5'-pyrophosphate
  • 2'-Deoxy-Cytidine pyrophosphate
  • 2'-Deoxycytidine 5'-diphosphate
  • 2'-Deoxycytidine diphosphate
  • 2'-Deoxycytidine-5'-diphosphate
800-73-7
genes like me logo Genes that share compounds with CMPK2: view

Transcripts for CMPK2 Gene

Unigene Clusters for CMPK2 Gene

Cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CMPK2 Gene

No ASD Table

Relevant External Links for CMPK2 Gene

GeneLoc Exon Structure for
CMPK2
ECgene alternative splicing isoforms for
CMPK2

Expression for CMPK2 Gene

mRNA expression in normal human tissues for CMPK2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CMPK2 Gene

This gene is overexpressed in Adrenal (22.0) and Spleen (9.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CMPK2 Gene



SOURCE GeneReport for Unigene cluster for CMPK2 Gene Hs.7155

mRNA Expression by UniProt/SwissProt for CMPK2 Gene

Q5EBM0-CMPK2_HUMAN
Tissue specificity: Among all investigated tumors, leukemia cells show the most abundant expression.
genes like me logo Genes that share expression patterns with CMPK2: view

Protein tissue co-expression partners for CMPK2 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for CMPK2 Gene

Orthologs for CMPK2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CMPK2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CMPK2 35
  • 82.95 (n)
  • 80.88 (a)
CMPK2 36
  • 77 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CMPK2 35
  • 84.04 (n)
  • 83.01 (a)
CMPK2 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cmpk2 35
  • 79.69 (n)
  • 76.55 (a)
Cmpk2 16
Cmpk2 36
  • 74 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CMPK2 35
  • 98.96 (n)
  • 99.33 (a)
CMPK2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cmpk2 35
  • 79.36 (n)
  • 76.63 (a)
oppossum
(Monodelphis domestica)
Mammalia CMPK2 36
  • 59 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CMPK2 36
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves CMPK2 36
  • 63 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CMPK2 36
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cmpk2 35
  • 59.2 (n)
  • 51.62 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.18881 35
zebrafish
(Danio rerio)
Actinopterygii cmpk2 35
  • 52.31 (n)
  • 47.11 (a)
cmpk2 36
  • 41 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5768 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 24 (a)
OneToOne
Species with no ortholog for CMPK2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CMPK2 Gene

ENSEMBL:
Gene Tree for CMPK2 (if available)
TreeFam:
Gene Tree for CMPK2 (if available)

Paralogs for CMPK2 Gene

No data available for Paralogs for CMPK2 Gene

Variants for CMPK2 Gene

Sequence variations from dbSNP and Humsavar for CMPK2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs6712141 - 6,849,902(+) GGACC(C/T)TTTCT intron-variant, nc-transcript-variant, reference, missense
rs13308 -- 6,848,538(+) TTATA(C/T)AGAAA intron-variant, nc-transcript-variant, utr-variant-3-prime
rs1448879 -- 6,857,196(+) GGTGA(C/T)TATAA intron-variant
rs2084493 -- 6,857,704(+) atctc(A/G)gctca intron-variant
rs1597248 -- 6,842,709(+) agttt(C/T)agcta intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CMPK2 Gene

Variant ID Type Subtype PubMed ID
nsv833326 CNV Loss 17160897

Variation tolerance for CMPK2 Gene

Gene Damage Index Score: 2.71; 46.40% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CMPK2 Gene

HapMap Linkage Disequilibrium report
CMPK2
Human Gene Mutation Database (HGMD)
CMPK2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CMPK2 Gene

Disorders for CMPK2 Gene

Relevant External Links for CMPK2

Genetic Association Database (GAD)
CMPK2
Human Genome Epidemiology (HuGE) Navigator
CMPK2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CMPK2

No disorders were found for CMPK2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CMPK2 Gene

Publications for CMPK2 Gene

  1. Human UMP-CMP kinase 2, a novel nucleoside monophosphate kinase localized in mitochondria. (PMID: 17999954) Xu Y. … Karlsson A. (J. Biol. Chem. 2008) 2 3 4 67
  2. The human adenylate kinase 9 is a nucleoside mono- and diphosphate kinase. (PMID: 23416111) Amiri M. … Solaroli N. (Int. J. Biochem. Cell Biol. 2013) 3
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3
  4. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3
  5. Identification of a putative human mitochondrial thymidine monophosphate kinase associated with monocytic/macrophage terminal differentiation. (PMID: 18498354) Chen Y.L. … Chang Z.F. (Genes Cells 2008) 3

Products for CMPK2 Gene

Sources for CMPK2 Gene

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