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CMPK2 Gene

protein-coding   GIFtS: 53
GCID: GC02M006980

Cytidine Monophosphate (UMP-CMP) Kinase 2, Mitochondrial

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cytidine Monophosphate (UMP-CMP) Kinase 2, Mitochondrial1 2     Mitochondrial UMP-CMP Kinase2
Cytidylate Kinase 21 2     Thymidine Monophosphate Kinase 22
Nucleoside-Diphosphate Kinase2 3     Thymidylate Kinase Family LPS-Inducible Member2
TMPK22     UMP-CMP Kinase 2, Mitochondrial2
TYKi2     EC 2.7.4.143
UMP-CMPK22     EC 2.7.4.63

External Ids:    HGNC: 270151   Entrez Gene: 1296072   Ensembl: ENSG000001343267   OMIM: 6117875   UniProtKB: Q5EBM03   

Export aliases for CMPK2 gene to outside databases

Previous GC identifers: GC02M006897 GC02M006834


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CMPK2 Gene:
This gene encodes one of the enzymes in the nucleotide synthesis salvage pathway that may participate in terminal
differentiation of monocytic cells. Multiple transcript variants encoding different isoforms have been found for
this gene. (provided by RefSeq, Feb 2012)

GeneCards Summary for CMPK2 Gene:
CMPK2 (cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial) is a protein-coding gene. GO annotations related to this gene include nucleoside diphosphate kinase activity and thymidylate kinase activity.

UniProtKB/Swiss-Prot: CMPK2_HUMAN, Q5EBM0
Function: May participate in dUTP and dCTP synthesis in mitochondria. Is able to phosphorylate dUMP, dCMP, CMP,
UMP and monophosphates of the pyrimidine nucleoside analogs ddC, dFdC, araC, BVDU and FdUrd with ATP as phosphate
donor. Efficacy is highest for dUMP followed by dCMP; CMP and UMP are poor substrates. May be involved in mtDNA
depletion caused by long term treatment with ddC or other pyrimidine analogs. Also displays broad nucleoside
diphosphate kinase activity




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NC_018913.2  NT_005334.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the CMPK2 gene promoter:
         NF-1   NF-1/L   Pax-5   STAT5A   NF-kappaB   c-Ets-1   AREB6   HEN1   Sox9   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCMPK2 promoter sequence
   Search Chromatin IP Primers for CMPK2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CMPK2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p25.2   Ensembl cytogenetic band:  2p25.2   HGNC cytogenetic band: 2p25.2

CMPK2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CMPK2 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M006980:  view genomic region     (about GC identifiers)

Start:
6,980,701 bp from pter      End:
7,006,766 bp from pter
Size:
26,066 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CMPK2_HUMAN, Q5EBM0 (See protein sequence)
Recommended Name: UMP-CMP kinase 2, mitochondrial precursor  
Size: 449 amino acids; 49448 Da
Secondary accessions: A2RUB0 A5D8T2 B7ZM18 Q6ZRU2 Q96AL8
Alternative splicing: 4 isoforms:  Q5EBM0-1   Q5EBM0-2   Q5EBM0-3   Q5EBM0-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CMPK2: NX_Q5EBM0

Explore proteomics data for CMPK2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys245, Lys277, Lys282, Lys393, Lys409

  • See CMPK2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001243406.1  NP_001243407.1  NP_997198.2  

    ENSEMBL proteins: 
     ENSP00000256722   ENSP00000384915   ENSP00000396385  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR014505 UMP-CMP_kinase_mit
     IPR027417 P-loop_NTPase

    Graphical View of Domain Structure for InterPro Entry Q5EBM0

    ProtoNet protein and cluster: Q5EBM0

    1 Blocks protein domain: IPB000062 Thymidylate kinase

    UniProtKB/Swiss-Prot: CMPK2_HUMAN, Q5EBM0
    Similarity: Belongs to the thymidylate kinase family


    Find genes that share domains with CMPK2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CMPK2_HUMAN, Q5EBM0
    Function: May participate in dUTP and dCTP synthesis in mitochondria. Is able to phosphorylate dUMP, dCMP, CMP,
    UMP and monophosphates of the pyrimidine nucleoside analogs ddC, dFdC, araC, BVDU and FdUrd with ATP as phosphate
    donor. Efficacy is highest for dUMP followed by dCMP; CMP and UMP are poor substrates. May be involved in mtDNA
    depletion caused by long term treatment with ddC or other pyrimidine analogs. Also displays broad nucleoside
    diphosphate kinase activity
    Catalytic activity: ATP + (d)CMP = ADP + (d)CDP
    Catalytic activity: ATP + nucleoside diphosphate = ADP + nucleoside triphosphate
    Biophysicochemical properties: Kinetic parameters: KM=3.09 mM for CMP; KM=6.3 mM for UMP; KM=1.31 mM for dCMP;
    KM=0.1 mM for dUMP; Vmax=1.64 umol/min/mg enzyme towards CMP; Vmax=0.19 umol/min/mg enzyme towards UMP; Vmax=1.77
    umol/min/mg enzyme towards dCMP; Vmax=0.48 umol/min/mg enzyme towards dUMP;

         Enzyme Numbers (IUBMB): EC 2.7.4.61 EC 2.7.4.141

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004127cytidylate kinase activity IDA17999954
    GO:0004550nucleoside diphosphate kinase activity IDA--
    GO:0004798thymidylate kinase activity IEA--
    GO:0005524ATP binding IEA--
    GO:0009041uridylate kinase activity ----
         
    Find genes that share ontologies with CMPK2           About GenesLikeMe


    Animal Models:
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    miRTarBase miRNAs that target CMPK2:
    hsa-mir-192-5p (MIRT026932)

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    6 qRT-PCR Assays for microRNAs that regulate CMPK2:
    hsa-miR-374a* hsa-miR-3658 hsa-miR-944 hsa-miR-519c-3p hsa-miR-519a hsa-miR-519b-3p
    SwitchGear 3'UTR luciferase reporter plasmidCMPK2 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CMPK2_HUMAN, Q5EBM0: Mitochondrion
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    nucleus4
    cytosol2

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005739mitochondrion IDA--

    Find genes that share ontologies with CMPK2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CMPK2 About    
    See pathways by source

    SuperPathContained pathways About
    1superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis
    superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis0.52
    superpathway of pyrimidine ribonucleotides de novo biosynthesis0.00
    superpathway of pyrimidine deoxyribonucleoside salvage0.46
    pyrimidine deoxyribonucleotide phosphorylation0.00
    UTP and CTP de novo biosynthesis0.00
    2Purine metabolism (KEGG)
    Pyrimidine metabolism0.38
    3Metabolism
    Metabolic pathways0.38


    Find genes that share SuperPaths with CMPK2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    5 BioSystems Pathways for CMPK2
        superpathway of pyrimidine ribonucleotides de novo biosynthesis
    superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis
    pyrimidine deoxyribonucleotide phosphorylation
    superpathway of pyrimidine deoxyribonucleoside salvage
    UTP and CTP de novo biosynthesis


    2 Kegg Pathways  (Kegg details for CMPK2):
        Pyrimidine metabolism
    Metabolic pathways

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CMPK2
    Interactions:

        Search GeneGlobe Interaction Network for CMPK2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CMPK2 (Q5EBM03 ENSP000002567224) via UniProtKB, MINT, STRING, and/or I2D (see all 39)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GABARAPL1Q9H0R83I2D: score=1 
    AK3ENSP000003712304STRING: ENSP00000371230
    DCKENSP000002866484STRING: ENSP00000286648
    DCTDENSP000003495764STRING: ENSP00000349576
    ITPAENSP000003694564STRING: ENSP00000369456
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006165nucleoside diphosphate phosphorylation IDA--
    GO:0006227dUDP biosynthetic process IEA--
    GO:0006233dTDP biosynthetic process IEA--
    GO:0009142nucleoside triphosphate biosynthetic process IDA--
    GO:0071222cellular response to lipopolysaccharide IEA--

    Find genes that share ontologies with CMPK2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CMPK2

    9 HMDB Compounds for CMPK2    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    CDPCDP (see all 3)63-38-7--
    Cytidine monophosphate5'-CMP (see all 14)63-37-6--
    Ergocalciferol(+)-Vitamin D2 (see all 72)50-14-6--
    Uridine 5'-diphosphate5'-UDP (see all 9)58-98-0--
    Uridine 5'-monophosphate5'-UMP (see all 12)58-97-9--
    dCDP2'-Deoxycytidine 5'-diphosphate (see all 13)800-73-7--
    dCMP2'-Deoxycytidine 5'-monophosphate (see all 12)1032-65-1--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CMPK2 gene (3 alternative transcripts): 
    NM_001256477.1  NM_001256478.1  NM_207315.3  

    Unigene Cluster for CMPK2:

    Cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial
    Hs.7155  [show with all ESTs]
    Unigene Representative Sequence: NM_207315
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000256722(uc002qyo.3) ENST00000478738 ENST00000491738(uc002qyn.1)
    ENST00000465619 ENST00000404168(uc010ewv.3) ENST00000470479 ENST00000458098(uc010yis.1)

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    hsa-miR-374a* hsa-miR-3658 hsa-miR-944 hsa-miR-519c-3p hsa-miR-519a hsa-miR-519b-3p
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    Additional mRNA sequence: 

    AK308509.1 BC016969.1 BC089425.1 BC132821.1 BC141802.1 BC144202.1 NR_046236.1 

    5 DOTS entries:

    DT.99931877  DT.453828  DT.95163235  DT.120968148  DT.100648168 

    Selected AceView cDNA sequences (see all 105):

    R50519 BG778349 BG776607 AA211082 BE748211 BC016969 BX421924 CR623316 
    BX463706 BM819858 AW152544 BG547557 BG497758 BG776519 BI818166 NM_207315 
    AA134487 AI538659 BX452339 BG778145 AI623742 BG497576 BE748748 AK127983 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CMPK2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATAAACTTT
    CMPK2 Expression
    About this image


    CMPK2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Endothelium (Cardiovascular System)
             Adult Endothelial Cells Blood Brain Barrier
     
     Brain (Nervous System)
             Adult Endothelial Cells Blood Brain Barrier
    CMPK2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CMPK2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.7155

    UniProtKB/Swiss-Prot: CMPK2_HUMAN, Q5EBM0
    Tissue specificity: Among all investigated tumors, leukemia cells show the most abundant expression

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CMPK2 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cmpk21 , 5 cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial1, 5 79.69(n)1
    76.55(a)1
      12 (9.69 cM)5
    221691  NM_020557.41  NP_065582.31 
     264692155 
    chicken
    (Gallus gallus)
    Aves CMPK26
    cytidine monophosphate (UMP-CMP) kinase 2, mitocho...
    63(a)
    1 ↔ 1
    3(94575875-94584183)
    lizard
    (Anolis carolinensis)
    Reptilia CMPK26
    cytidine monophosphate (UMP-CMP) kinase 2, mitocho...
    68(a)
    1 ↔ 1
    1(150144151-150154818)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.188812 Xenopus laevis transcribed sequence with weak similarity more 76.82(n)    BI447531.1 
    zebrafish
    (Danio rerio)
    Actinopterygii cmpk21 cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial 52.31(n)
    47.11(a)
      570478  XM_693963.5  XP_699055.5 


    ENSEMBL Gene Tree for CMPK2 (if available)
    TreeFam Gene Tree for CMPK2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CMPK2 (see all 529)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1831895981,2
    --6980235(+) TATCTC/TTTGCC 1 -- ds50010--------
    rs745873841,2
    --6980338(+) CAGTAG/TGCAGT 1 -- ds50010--------
    rs1878055491,2
    --6980357(+) AAAGAG/TCAAGG 1 -- ds50010--------
    rs1480141511,2
    --6980380(+) TTCCCA/GTATGT 1 -- ds50010--------
    rs1929375671,2
    --6980406(+) TCCACC/TTTAAA 1 -- ds50010--------
    rs1424899711,2
    --6980423(+) TCACCA/GAGATA 1 -- ds50010--------
    rs1841728961,2
    --6980425(+) ACCGAA/GATATA 1 -- ds50010--------
    rs769237851,2
    C,F--6980446(+) GTGGGG/TGTGGT 1 -- ds50011Minor allele frequency- T:0.10EA 120
    rs1446492491,2
    --6980467(+) ATGAAC/TGGAAT 1 -- ds50010--------
    rs126178151,2
    C,F,H--6980931(+) aactgG/Tgccag 1 -- int113Minor allele frequency- T:0.09NS EA NA 1938

    HapMap Linkage Disequilibrium report for CMPK2 (6980701 - 7006766 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for CMPK2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv833326CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CMPK2
    DNA2.0 Custom Variant and Variant Library Synthesis for CMPK2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611787    OMIM disorders: --


    Find genes that share disorders with CMPK2           About GenesLikeMe

    Genetic Association Database (GAD): CMPK2
    Human Genome Epidemiology (HuGE) Navigator: CMPK2 (1 document)

    Export disorders for CMPK2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CMPK2 gene, integrated from 10 sources (see all 11):
    (articles sorted by number of sources associating them with CMPK2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human UMP-CMP kinase 2, a novel nucleoside monophosphate kinase localized in mitochondria. (PubMed id 17999954)1, 2, 3 Xu Y.... Karlsson A. (J. Biol. Chem. 2008)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. The human adenylate kinase 9 is a nucleoside mono- and diphosphate kinase. (PubMed id 23416111)2 Amiri M....Solaroli N. (amp 2013)
    4. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    5. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    6. Identification of a putative human mitochondrial thymidine monophosphate kinase associated with monocytic/macrophage terminal differentiation. (PubMed id 18498354)1 Chen Y.L....Chang Z.F. (amp 2008)
    7. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)
    8. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 129607 HGNC: 27015 AceView: LOC129607 Ensembl:ENSG00000134326 euGenes: HUgn129607
    ECgene: CMPK2 Kegg: 129607 H-InvDB: CMPK2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CMPK2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CMPK2 gene:
    Search GeneIP for patents involving CMPK2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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