Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CMPK2 Gene

Aliases for CMPK2 Gene

  • Cytidine/Uridine Monophosphate Kinase 2 2 3 5
  • Nucleoside-Diphosphate Kinase 2 3 4
  • Cytidine Monophosphate (UMP-CMP) Kinase 2, Mitochondrial 2 3
  • Cytidylate Kinase 2 2 3
  • UMP/CMP Kinase 2 3
  • Thymidylate Kinase Family LPS-Inducible Member 3
  • Thymidine Monophosphate Kinase 2 3
  • UMP-CMP Kinase 2, Mitochondrial 3
  • Mitochondrial UMP-CMP Kinase 3
  • EC 2.7.4.14 4
  • EC 2.7.4.6 4
  • UMP-CMPK2 3
  • TMPK2 3
  • TYKi 3
  • NDK 3

External Ids for CMPK2 Gene

Previous GeneCards Identifiers for CMPK2 Gene

  • GC02M006897
  • GC02M006980

Summaries for CMPK2 Gene

Entrez Gene Summary for CMPK2 Gene

  • This gene encodes one of the enzymes in the nucleotide synthesis salvage pathway that may participate in terminal differentiation of monocytic cells. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]

GeneCards Summary for CMPK2 Gene

CMPK2 (Cytidine/Uridine Monophosphate Kinase 2) is a Protein Coding gene. Among its related pathways are superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis and Metabolism. GO annotations related to this gene include nucleoside diphosphate kinase activity and uridylate kinase activity.

UniProtKB/Swiss-Prot for CMPK2 Gene

  • May participate in dUTP and dCTP synthesis in mitochondria. Is able to phosphorylate dUMP, dCMP, CMP, UMP and monophosphates of the pyrimidine nucleoside analogs ddC, dFdC, araC, BVDU and FdUrd with ATP as phosphate donor. Efficacy is highest for dUMP followed by dCMP; CMP and UMP are poor substrates. May be involved in mtDNA depletion caused by long term treatment with ddC or other pyrimidine analogs. Also displays broad nucleoside diphosphate kinase activity.

Additional gene information for CMPK2 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CMPK2 Gene

Genomics for CMPK2 Gene

Regulatory Elements for CMPK2 Gene

Enhancers for CMPK2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02H006908 1.5 Ensembl ENCODE dbSUPER 11.4 -43.4 -43398 3 HDGF PKNOX1 ARNT TCF12 ZNF766 GATA2 ATF7 RUNX3 NCOA1 ZNF592 CMPK2 RSAD2 ENSG00000271947 RNF144A
GH02H006887 1.2 ENCODE dbSUPER 12.1 -21.3 -21255 1 ATF1 ARNT TCF12 ZNF766 CBX5 GATA2 ATF7 NCOA1 REST ZNF592 RSAD2 CMPK2 RNF144A RNF144A-AS1 GC02P006897
GH02H006858 0.7 FANTOM5 dbSUPER 16.2 +8.1 8146 0 ZNF707 RSAD2 CMPK2 NRIR
GH02H006919 1 ENCODE dbSUPER 11.1 -52.6 -52570 0 SOX13 ATF1 SAP130 ARID4B EBF1 ZIC2 RARA NR2F6 HOMEZ EZH2 CMPK2 RNF144A-AS1 GC02M007018
GH02H006857 0.8 FANTOM5 dbSUPER 12.1 +9.5 9459 0 CEBPB MAFG NFE2 RSAD2 CMPK2 NRIR
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CMPK2 on UCSC Golden Path with GeneCards custom track

Promoters for CMPK2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000112227 1035 1201 HDGF ATF1 ZFP64 TCF12 GATA2 ELK1 ZNF207 ATF7 REST ZNF592

Genomic Location for CMPK2 Gene

Chromosome:
2
Start:
6,840,417 bp from pter
End:
6,866,635 bp from pter
Size:
26,219 bases
Orientation:
Minus strand

Genomic View for CMPK2 Gene

Genes around CMPK2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CMPK2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CMPK2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CMPK2 Gene

Proteins for CMPK2 Gene

  • Protein details for CMPK2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5EBM0-CMPK2_HUMAN
    Recommended name:
    UMP-CMP kinase 2, mitochondrial
    Protein Accession:
    Q5EBM0
    Secondary Accessions:
    • A2RUB0
    • A5D8T2
    • B7ZM18
    • Q6ZRU2
    • Q96AL8

    Protein attributes for CMPK2 Gene

    Size:
    449 amino acids
    Molecular mass:
    49448 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CMPK2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CMPK2 Gene

Post-translational modifications for CMPK2 Gene

  • Ubiquitination at posLast=245245, posLast=277277, posLast=282282, Lys393, and Lys409
  • Modification sites at PhosphoSitePlus

Other Protein References for CMPK2 Gene

No data available for DME Specific Peptides for CMPK2 Gene

Domains & Families for CMPK2 Gene

Gene Families for CMPK2 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for CMPK2 Gene

Suggested Antigen Peptide Sequences for CMPK2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5EBM0

UniProtKB/Swiss-Prot:

CMPK2_HUMAN :
  • Belongs to the thymidylate kinase family.
Family:
  • Belongs to the thymidylate kinase family.
genes like me logo Genes that share domains with CMPK2: view

Function for CMPK2 Gene

Molecular function for CMPK2 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=3.09 mM for CMP; KM=6.3 mM for UMP; KM=1.31 mM for dCMP; KM=0.1 mM for dUMP; Vmax=1.64 umol/min/mg enzyme towards CMP; Vmax=0.19 umol/min/mg enzyme towards UMP; Vmax=1.77 umol/min/mg enzyme towards dCMP; Vmax=0.48 umol/min/mg enzyme towards dUMP;
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + (d)CMP = ADP + (d)CDP.
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + nucleoside diphosphate = ADP + nucleoside triphosphate.
UniProtKB/Swiss-Prot Function:
May participate in dUTP and dCTP synthesis in mitochondria. Is able to phosphorylate dUMP, dCMP, CMP, UMP and monophosphates of the pyrimidine nucleoside analogs ddC, dFdC, araC, BVDU and FdUrd with ATP as phosphate donor. Efficacy is highest for dUMP followed by dCMP; CMP and UMP are poor substrates. May be involved in mtDNA depletion caused by long term treatment with ddC or other pyrimidine analogs. Also displays broad nucleoside diphosphate kinase activity.

Enzyme Numbers (IUBMB) for CMPK2 Gene

Gene Ontology (GO) - Molecular Function for CMPK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004127 cytidylate kinase activity IDA 17999954
GO:0004550 nucleoside diphosphate kinase activity IEA,IDA 23416111
GO:0004798 thymidylate kinase activity IBA --
GO:0005524 ATP binding IEA --
GO:0009041 uridylate kinase activity IEA --
genes like me logo Genes that share ontologies with CMPK2: view

Phenotypes for CMPK2 Gene

genes like me logo Genes that share phenotypes with CMPK2: view

Animal Models for CMPK2 Gene

MGI Knock Outs for CMPK2:

Animal Model Products

CRISPR Products

miRNA for CMPK2 Gene

miRTarBase miRNAs that target CMPK2

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for CMPK2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CMPK2 Gene

Localization for CMPK2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CMPK2 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CMPK2 gene
Compartment Confidence
mitochondrion 5
nucleus 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CMPK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA,IDA 17999954
genes like me logo Genes that share ontologies with CMPK2: view

Pathways & Interactions for CMPK2 Gene

genes like me logo Genes that share pathways with CMPK2: view

Gene Ontology (GO) - Biological Process for CMPK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006165 nucleoside diphosphate phosphorylation IDA 23416111
GO:0006221 pyrimidine nucleotide biosynthetic process IEA --
GO:0006227 dUDP biosynthetic process IBA --
GO:0006233 dTDP biosynthetic process IBA --
GO:0006235 dTTP biosynthetic process IBA --
genes like me logo Genes that share ontologies with CMPK2: view

No data available for SIGNOR curated interactions for CMPK2 Gene

Drugs & Compounds for CMPK2 Gene

(7) Drugs for CMPK2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Ergocalciferol Approved Nutra 1313
CDP Experimental Pharma 0
Cytidine monophosphate Experimental Pharma 0
dCMP Experimental Pharma 0
Uridine monophosphate Experimental Pharma 0

(2) Additional Compounds for CMPK2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
dcdp
  • 2'-Deoxy-Cytidine 5'-pyrophosphate
  • 2'-Deoxy-Cytidine pyrophosphate
  • 2'-Deoxycytidine 5'-diphosphate
  • 2'-Deoxycytidine diphosphate
  • 2'-Deoxycytidine-5'-diphosphate
800-73-7
genes like me logo Genes that share compounds with CMPK2: view

Transcripts for CMPK2 Gene

Unigene Clusters for CMPK2 Gene

Cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for CMPK2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for CMPK2 Gene

No ASD Table

Relevant External Links for CMPK2 Gene

GeneLoc Exon Structure for
CMPK2
ECgene alternative splicing isoforms for
CMPK2

Expression for CMPK2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CMPK2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CMPK2 Gene

This gene is overexpressed in Adrenal (22.0) and Spleen (9.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CMPK2 Gene



Protein tissue co-expression partners for CMPK2 Gene

NURSA nuclear receptor signaling pathways regulating expression of CMPK2 Gene:

CMPK2

SOURCE GeneReport for Unigene cluster for CMPK2 Gene:

Hs.7155

mRNA Expression by UniProt/SwissProt for CMPK2 Gene:

Q5EBM0-CMPK2_HUMAN
Tissue specificity: Among all investigated tumors, leukemia cells show the most abundant expression.
genes like me logo Genes that share expression patterns with CMPK2: view

Primer Products

No data available for mRNA differential expression in normal tissues , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CMPK2 Gene

Orthologs for CMPK2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CMPK2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CMPK2 33 34
  • 98.96 (n)
dog
(Canis familiaris)
Mammalia CMPK2 33 34
  • 84.04 (n)
cow
(Bos Taurus)
Mammalia CMPK2 33 34
  • 82.95 (n)
mouse
(Mus musculus)
Mammalia Cmpk2 33 16 34
  • 79.69 (n)
rat
(Rattus norvegicus)
Mammalia Cmpk2 33
  • 79.36 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CMPK2 34
  • 75 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CMPK2 34
  • 59 (a)
OneToOne
chicken
(Gallus gallus)
Aves CMPK2 34
  • 63 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CMPK2 34
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cmpk2 33
  • 59.2 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.18881 33
zebrafish
(Danio rerio)
Actinopterygii cmpk2 33 34
  • 52.31 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5768 33
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 24 (a)
OneToOne
Species where no ortholog for CMPK2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CMPK2 Gene

ENSEMBL:
Gene Tree for CMPK2 (if available)
TreeFam:
Gene Tree for CMPK2 (if available)

Paralogs for CMPK2 Gene

No data available for Paralogs for CMPK2 Gene

Variants for CMPK2 Gene

Sequence variations from dbSNP and Humsavar for CMPK2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000197199 -- 6,856,404(+) GGTGG(A/G)GGCAG intron-variant
rs1000218848 -- 6,854,104(+) CAGAT(A/G)AATTT intron-variant
rs1000248419 -- 6,845,585(+) CCTGC(A/C)TAAGG intron-variant
rs1000305363 -- 6,855,602(+) TTCCC(A/G)TAAAG intron-variant
rs1000563095 -- 6,856,822(+) GTGTG(C/T)CCTCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CMPK2 Gene

Variant ID Type Subtype PubMed ID
esv2667897 CNV deletion 23128226
esv3589733 CNV loss 21293372
nsv833326 CNV loss 17160897

Variation tolerance for CMPK2 Gene

Gene Damage Index Score: 2.71; 46.40% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CMPK2 Gene

Human Gene Mutation Database (HGMD)
CMPK2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CMPK2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CMPK2 Gene

Disorders for CMPK2 Gene

Relevant External Links for CMPK2

Genetic Association Database (GAD)
CMPK2
Human Genome Epidemiology (HuGE) Navigator
CMPK2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CMPK2

No disorders were found for CMPK2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CMPK2 Gene

Publications for CMPK2 Gene

  1. Human UMP-CMP kinase 2, a novel nucleoside monophosphate kinase localized in mitochondria. (PMID: 17999954) Xu Y … Karlsson A (The Journal of biological chemistry 2008) 2 3 4 60
  2. The human adenylate kinase 9 is a nucleoside mono- and diphosphate kinase. (PMID: 23416111) Amiri M … Solaroli N (The international journal of biochemistry & cell biology 2013) 3 4 60
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  4. Initial characterization of the human central proteome. (PMID: 21269460) Burkard TR … Colinge J (BMC systems biology 2011) 4 60
  5. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L … Andersson-Svahn H (Molecular & cellular proteomics : MCP 2008) 3 60

Products for CMPK2 Gene

Sources for CMPK2 Gene

Content
Loading form....