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Aliases for CMPK2 Gene

Aliases for CMPK2 Gene

  • Cytidine Monophosphate (UMP-CMP) Kinase 2, Mitochondrial 2 3
  • Nucleoside-Diphosphate Kinase 3 4
  • Cytidylate Kinase 2 2 3
  • Thymidylate Kinase Family LPS-Inducible Member 3
  • Thymidine Monophosphate Kinase 2 3
  • UMP-CMP Kinase 2, Mitochondrial 3
  • Mitochondrial UMP-CMP Kinase 3
  • EC 2.7.4.14 4
  • EC 2.7.4.6 4
  • UMP-CMPK2 3
  • TMPK2 3
  • TYKi 3

External Ids for CMPK2 Gene

Summaries for CMPK2 Gene

Entrez Gene Summary for CMPK2 Gene

  • This gene encodes one of the enzymes in the nucleotide synthesis salvage pathway that may participate in terminal differentiation of monocytic cells. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]

GeneCards Summary for CMPK2 Gene

CMPK2 (Cytidine Monophosphate (UMP-CMP) Kinase 2, Mitochondrial) is a Protein Coding gene. Among its related pathways are Metabolism and superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis. GO annotations related to this gene include nucleoside diphosphate kinase activity and thymidylate kinase activity.

UniProtKB/Swiss-Prot for CMPK2 Gene

  • May participate in dUTP and dCTP synthesis in mitochondria. Is able to phosphorylate dUMP, dCMP, CMP, UMP and monophosphates of the pyrimidine nucleoside analogs ddC, dFdC, araC, BVDU and FdUrd with ATP as phosphate donor. Efficacy is highest for dUMP followed by dCMP; CMP and UMP are poor substrates. May be involved in mtDNA depletion caused by long term treatment with ddC or other pyrimidine analogs. Also displays broad nucleoside diphosphate kinase activity.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CMPK2 Gene

Genomics for CMPK2 Gene

Genomic Location for CMPK2 Gene

Start:
6,840,553 bp from pter
End:
6,866,635 bp from pter
Size:
26,083 bases
Orientation:
Minus strand

Genomic View for CMPK2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CMPK2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CMPK2 Gene

Regulatory Elements for CMPK2 Gene

Proteins for CMPK2 Gene

  • Protein details for CMPK2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5EBM0-CMPK2_HUMAN
    Recommended name:
    UMP-CMP kinase 2, mitochondrial
    Protein Accession:
    Q5EBM0
    Secondary Accessions:
    • A2RUB0
    • A5D8T2
    • B7ZM18
    • Q6ZRU2
    • Q96AL8

    Protein attributes for CMPK2 Gene

    Size:
    449 amino acids
    Molecular mass:
    49448 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CMPK2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CMPK2 Gene

Proteomics data for CMPK2 Gene at MOPED

Post-translational modifications for CMPK2 Gene

  • Ubiquitination at Lys245, Lys277, Lys282, Lys393, and Lys409

Other Protein References for CMPK2 Gene

No data available for DME Specific Peptides for CMPK2 Gene

Domains for CMPK2 Gene

Protein Domains for CMPK2 Gene

UniProtKB/Swiss-Prot:

CMPK2_HUMAN
Family:
  • Belongs to the thymidylate kinase family.:
    • Q5EBM0
genes like me logo Genes that share domains with CMPK2: view

No data available for Gene Families for CMPK2 Gene

Function for CMPK2 Gene

Molecular function for CMPK2 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=3.09 mM for CMP; KM=6.3 mM for UMP; KM=1.31 mM for dCMP; KM=0.1 mM for dUMP; Vmax=1.64 umol/min/mg enzyme towards CMP; Vmax=0.19 umol/min/mg enzyme towards UMP; Vmax=1.77 umol/min/mg enzyme towards dCMP; Vmax=0.48 umol/min/mg enzyme towards dUMP;
UniProtKB/Swiss-Prot CatalyticActivity: ATP + (d)CMP = ADP + (d)CDP.
UniProtKB/Swiss-Prot CatalyticActivity: ATP + nucleoside diphosphate = ADP + nucleoside triphosphate.
UniProtKB/Swiss-Prot Function: May participate in dUTP and dCTP synthesis in mitochondria. Is able to phosphorylate dUMP, dCMP, CMP, UMP and monophosphates of the pyrimidine nucleoside analogs ddC, dFdC, araC, BVDU and FdUrd with ATP as phosphate donor. Efficacy is highest for dUMP followed by dCMP; CMP and UMP are poor substrates. May be involved in mtDNA depletion caused by long term treatment with ddC or other pyrimidine analogs. Also displays broad nucleoside diphosphate kinase activity.

Enzyme Numbers (IUBMB) for CMPK2 Gene

Gene Ontology (GO) - Molecular Function for CMPK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004127 cytidylate kinase activity IDA 17999954
GO:0004550 nucleoside diphosphate kinase activity IDA 23416111
GO:0004798 thymidylate kinase activity IBA --
GO:0005524 ATP binding IEA --
GO:0009041 uridylate kinase activity --
genes like me logo Genes that share ontologies with CMPK2: view

miRNA for CMPK2 Gene

miRTarBase miRNAs that target CMPK2

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for CMPK2 Gene

Localization for CMPK2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CMPK2 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CMPK2 Gene COMPARTMENTS Subcellular localization image for CMPK2 gene
Compartment Confidence
mitochondrion 5
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for CMPK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005739 mitochondrion IDA --
GO:0005829 cytosol IBA --
genes like me logo Genes that share ontologies with CMPK2: view

Pathways for CMPK2 Gene

genes like me logo Genes that share pathways with CMPK2: view

Interacting Proteins for CMPK2 Gene

Gene Ontology (GO) - Biological Process for CMPK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006165 nucleoside diphosphate phosphorylation IDA 23416111
GO:0006227 dUDP biosynthetic process IBA --
GO:0006233 dTDP biosynthetic process IBA --
GO:0006235 dTTP biosynthetic process IBA --
GO:0009142 nucleoside triphosphate biosynthetic process IDA 23416111
genes like me logo Genes that share ontologies with CMPK2: view

Compounds for CMPK2 Gene

(9) HMDB Compounds for CMPK2 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
CDP
  • CDP
63-38-7
Cytidine monophosphate
  • 5'-CMP
63-37-6
dCDP
  • 2'-Deoxycytidine 5'-diphosphate
800-73-7
genes like me logo Genes that share compounds with CMPK2: view

Transcripts for CMPK2 Gene

Unigene Clusters for CMPK2 Gene

Cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CMPK2 Gene

No ASD Table

Relevant External Links for CMPK2 Gene

GeneLoc Exon Structure for
CMPK2
ECgene alternative splicing isoforms for
CMPK2

Expression for CMPK2 Gene

mRNA expression in normal human tissues for CMPK2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CMPK2 Gene

SOURCE GeneReport for Unigene cluster for CMPK2 Gene Hs.7155

mRNA Expression by UniProt/SwissProt for CMPK2 Gene

Q5EBM0-CMPK2_HUMAN
Tissue specificity: Among all investigated tumors, leukemia cells show the most abundant expression.
genes like me logo Genes that share expressions with CMPK2: view

Orthologs for CMPK2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CMPK2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CMPK2 36
  • 98.96 (n)
  • 99.33 (a)
CMPK2 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CMPK2 36
  • 82.95 (n)
  • 80.88 (a)
CMPK2 37
  • 77 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CMPK2 36
  • 84.04 (n)
  • 83.01 (a)
CMPK2 37
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cmpk2 36
  • 79.69 (n)
  • 76.55 (a)
Cmpk2 16
Cmpk2 37
  • 74 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CMPK2 37
  • 59 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CMPK2 37
  • 75 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cmpk2 36
  • 79.36 (n)
  • 76.63 (a)
chicken
(Gallus gallus)
Aves CMPK2 37
  • 63 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CMPK2 37
  • 68 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.18881 36
tropical clawed frog
(Silurana tropicalis)
Amphibia cmpk2 36
  • 59.2 (n)
  • 51.62 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5768 36
zebrafish
(Danio rerio)
Actinopterygii cmpk2 36
  • 52.31 (n)
  • 47.11 (a)
cmpk2 37
  • 41 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 24 (a)
OneToOne
Species with no ortholog for CMPK2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CMPK2 Gene

ENSEMBL:
Gene Tree for CMPK2 (if available)
TreeFam:
Gene Tree for CMPK2 (if available)

Paralogs for CMPK2 Gene

No data available for Paralogs for CMPK2 Gene

Variants for CMPK2 Gene

Sequence variations from dbSNP and Humsavar for CMPK2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs1597248 -- 6,842,709(+) agttt(C/T)agcta intron-variant
rs2197829 -- 6,843,960(+) aaatt(A/G)agccc intron-variant
rs2595165 -- 6,843,217(+) gcaga(A/G)aaaga intron-variant
rs6726632 -- 6,843,319(+) aatta(A/C)agctt intron-variant
rs6727045 -- 6,843,606(+) gattt(A/C)tacta intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CMPK2 Gene

Variant ID Type Subtype PubMed ID
nsv833326 CNV Loss 17160897

Relevant External Links for CMPK2 Gene

HapMap Linkage Disequilibrium report
CMPK2
Human Gene Mutation Database (HGMD)
CMPK2

Disorders for CMPK2 Gene

Relevant External Links for CMPK2

Genetic Association Database (GAD)
CMPK2
Human Genome Epidemiology (HuGE) Navigator
CMPK2
genes like me logo Genes that share disorders with CMPK2: view

No data available for UniProtKB/Swiss-Prot for CMPK2 Gene

Publications for CMPK2 Gene

  1. Human UMP-CMP kinase 2, a novel nucleoside monophosphate kinase localized in mitochondria. (PMID: 17999954) Xu Y. … Karlsson A. (J. Biol. Chem. 2008) 2 3 4
  2. The human adenylate kinase 9 is a nucleoside mono- and diphosphate kinase. (PMID: 23416111) Amiri M. … Solaroli N. (Int. J. Biochem. Cell Biol. 2013) 3 4
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 49
  4. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PMID: 22505724) Udeshi N.D. … Carr S.A. (Mol. Cell Proteomics 2012) 3
  5. A COFRADIC protocol to study protein ubiquitination. (PMID: 24816145) Stes E. … Gevaert K. (J. Proteome Res. 2014) 3

Products for CMPK2 Gene

Sources for CMPK2 Gene

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