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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CMPK1 Gene

protein-coding   GIFtS: 61
GCID: GC01P047799

cytidine monophosphate (UMP-CMP) kinase 1, cytosolic

(Previous name: cytidylate kinase )
(Previous symbol: CMPK)
 Explore 10 diseases affiliated with
CMPK1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CMPK1    

Aliases
for CMPK1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Cytidine Monophosphate (UMP-CMP) Kinase 1, Cytosolic1 2     Uridine Monophosphate/Cytidine Monophosphate Kinase2 3
CMPK1 2 3 5     UMP/CMP Kinase2 3
Cytidylate Kinase1 2 3     EC 2.7.4.143 8
CMK2 3 5     UMP-CMP Kinase2
UMK2 3 5     UCK3
UMPK2 3 5     UMP/CMPK3
UMP-CMPK1 2     Cytidine Monophosphate Kinase3
Deoxycytidylate Kinase2 3     EC 2.7.48
Uridine Monophosphate Kinase2 3     

External Ids:    HGNC: 181701   Entrez Gene: 517272   Ensembl: ENSG000001623687   OMIM: 1917105   UniProtKB: P300853   

Export aliases for CMPK1 gene to outside databases

Previous GC identifers: GC01P047572 GC01P045915


Summaries
for CMPK1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CMPK1:
This gene encodes one of the enzymes required for cellular nucleic acid biosynthesis. This enzyme catalyzes the
transfer of a phosphate group from ATP to CMP, UMP, or dCMP, to form the corresponding diphosphate nucleotide.
Alternate splicing results in both coding and non-coding transcript variants. (provided by RefSeq, Feb 2012)

UniProtKB/Swiss-Prot: KCY_HUMAN, P30085
Function: Catalyzes specific phosphoryl transfer from ATP to UMP and CMP

Gene Wiki entry for CMPK1 (CMPK)


Genomic Views
for CMPK1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_032977.9  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CMPK1 gene promoter:
         E2F-3a   E2F-4   E2F-5   E2F-2   RORalpha2   c-Rel   E2F-1   E2F   FOXC1   c-Myb   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CMPK1 promoter sequence
   Search SABiosciences Chromatin IP Primers for CMPK1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CMPK1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p32   Ensembl cytogenetic band:  1p33   HGNC cytogenetic band: 1p34.1-p33

CMPK1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CMPK1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P047799:  view genomic region     (about GC identifiers)

Start:
 47,799,469 bp from pter      End:
 47,844,511 bp from pter
Size:
 45,043 bases      Orientation:
 plus strand

Proteins
for CMPK1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: KCY_HUMAN, P30085 (See protein sequence)
Recommended Name: UMP-CMP kinase  
Size: 196 amino acids; 22222 Da
Cofactor: Magnesium
Subcellular location: Nucleus. Cytoplasm. Note=Mainly nuclear
Sequence caution: Sequence=AAF17709.1; Type=Erroneous initiation; Sequence=AAH14961.1; Type=Erroneous initiation;
Sequence=BAD96734.1; Type=Erroneous initiation; Sequence=CAI13471.1; Type=Erroneous gene model prediction;
Sequence=CAI14972.1; Type=Erroneous gene model prediction;
1 PDB 3D structure from and Proteopedia for CMPK1:
1TEV (3D)    
Secondary accessions: Q53GB7 Q5SVZ0 Q96C07 Q9UBQ8 Q9UIA2

Explore the universe of human proteins at neXtProt for CMPK1: NX_P30085

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P30085

    • 4/14 DME Specific Peptides for CMPK1 (P30085) (see all 14)
     MDGKADV  SGRSDDN  LLRDERK  SQYGELI 

    CMPK1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001129612.1  NP_057392.1  

    ENSEMBL proteins: 
     ENSP00000360939   ENSP00000360937   ENSP00000433782   ENSP00000398192  
    Reactome Protein details: P30085
    Human Recombinant Protein Products: 
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    Uscn Proteins for CMPK1

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm TAS10462544
    GO:0005829cytosol TAS--


    CMPK1 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for CMPK1

    Protein Domains /
    Families
    for CMPK1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CMPK1 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR000850 Adenylate_kin
     IPR006266 UMP_CMP_kinase

    Graphical View of Domain Structure for InterPro Entry P30085

    ProtoNet protein and cluster: P30085

    1 Blocks protein family: IPB000850 Adenylate kinase

    UniProtKB/Swiss-Prot: KCY_HUMAN, P30085
    Similarity: Belongs to the adenylate kinase family


    Function
    for CMPK1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: KCY_HUMAN, P30085
    Function: Catalyzes specific phosphoryl transfer from ATP to UMP and CMP
    Catalytic activity: ATP + (d)CMP = ADP + (d)CDP
    Catalytic activity: ATP + UMP = ADP + UDP

    Enzyme Numbers (IUBMB): EC 2.7.4.141 2 EC 2.7.42

    miRNA
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    hsa-miR-576-3p hsa-miR-520e hsa-miR-302d hsa-miR-106a hsa-miR-15a hsa-miR-29a hsa-miR-503 hsa-miR-301a
    SwitchGear 3'UTR luciferase reporter plasmid: CMPK1 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004127cytidylate kinase activity IEA--
    GO:0004849uridine kinase activity TAS10462544
    GO:0005524ATP binding IEA--
    GO:0016776phosphotransferase activity, phosphate group as acceptor ----
    GO:0019205nucleobase-containing compound kinase activity ----


    CMPK1 for ontologies           About GeneDecksing


    Animal Models:
         1 MGI phenotypic allele for Cmpk1 (no phenotypes)

    CMPK1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for CMPK1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Metabolism
    		Metabolism1.00
    		Metabolic pathways0.38
    2pyrimidine ribonucleotides interconversion
    		pyrimidine ribonucleotides interconversion1.00
    		pyrimidine ribonucleotides de novo biosynthesis0.88
    3Synthesis and interconversion of nucleotide di- and triphosphates
    		Synthesis and interconversion of nucleotide di- and triphosphates1.00
    4Gemcitabine Pathway, Pharmacodynamics
    		Gemcitabine Pathway, Pharmacodynamics1.00
    5Lamivudine Pathway, Pharmacokinetics/Pharmacodynamics
    		Lamivudine Pathway, Pharmacokinetics/Pharmacodynamics1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    2 BioSystems Pathways for CMPK1 
        pyrimidine ribonucleotides interconversion
    pyrimidine ribonucleotides de novo biosynthesis

    3        Reactome Pathways for CMPK1
        Metabolism of nucleotides
    Synthesis and interconversion of nucleotide di- and triphosphates
    Metabolism

    2 PharmGKB Pathways for CMPK1
        Gemcitabine Pathway, Pharmacodynamics
    Lamivudine Pathway, Pharmacokinetics/Pharmacodynamics

    2         Kegg Pathways  (Kegg details for CMPK1):
        Pyrimidine metabolism
    Metabolic pathways


    CMPK1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CMPK1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/69 Interacting proteins for CMPK1 (P300852, 3 ENSP000003609394) via UniProtKB, MINT, STRING, and/or I2D (see all 69)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YWHAZP631042, 3, ENSP000003095034MINT-3296474 I2D: score=1 STRING: ENSP00000309503
    BACE1P568173, ENSP000003185854I2D: score=2 STRING: ENSP00000318585
    EIF6P565373, ENSP000003635594I2D: score=1 STRING: ENSP00000363559
    DTYMKP239193, ENSP000003048024I2D: score=1 STRING: ENSP00000304802
    ATG5Q9H1Y03, ENSP000003433134I2D: score=1 STRING: ENSP00000343313
    About this table

    Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006139nucleobase-containing compound metabolic process ----
    GO:0006222UMP biosynthetic process TAS10462544
    GO:0006225UDP biosynthetic process IEA--
    GO:0006227dUDP biosynthetic process IEA--
    GO:0006240dCDP biosynthetic process IEA--


    CMPK1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for CMPK1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CMPK1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CMPK1

    1 HMDB Compound for CMPK1    About this table
    CompoundSynonyms CAS #PubMed Ids
    MagnesiumMagnesium (see all 2)7439-95-4--

    6 DrugBank Compounds for CMPK1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Gemcitabine-- 95058-81-4targetinhibitor16041392 17000136 17565005 15550676
    Adenosine-5'-Diphosphate-- 20398-34-9target--17139284 17016423 10592235
    Cytidine-5'-Monophosphate-- 84-52-6target--17139284 17016423 10592235
    P1-(Adenosine-5'-P5-(Uridine-5')Pentaphosphate-- --target--17139284 17016423 10592235
    Tetrafluoroaluminate Ion-- --target--17139284 17016423 10592235
    Uridine-5'-Diphosphate-- 58-98-0target--17139284 17016423 10592235

    10/17 Novoseek chemical compound relationships for CMPK1 gene (see all 17)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    dcmp 93 16 15550676 (4), 10462544 (1), 18343960 (1), 19181797 (1) (see all 10)
    nucleoside monophosphate 90.4 1 12694191 (1)
    poly c 83.8 19 18343960 (3), 8586070 (1), 19876400 (1), 19765547 (1) (see all 7)
    deoxycytidine 82.5 7 10462544 (2), 11912132 (1), 19876400 (1), 19765547 (1) (see all 5)
    triphosphate 75.5 1 17101674 (1)
    cytidine 73.5 8 15130468 (3), 15280220 (1), 11494055 (1), 12876357 (1)
    ctp 70.6 2 12694191 (1), 15130468 (1)
    pyrimidine 69.3 5 15550676 (2), 19765547 (1)
    uridine 68.9 10 15130468 (2), 15280220 (1), 11494055 (1), 12876357 (1) (see all 5)
    poly u 66.5 5 10218107 (1), 16041392 (1), 17000136 (1)

    Search CenterWatch for drugs/clinical trials and news about CMPK1 / KCY 

    Transcripts
    for CMPK1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CMPK1 gene (2 alternative transcripts): 
    NM_001136140.1  NM_016308.2  

    Unigene Cluster for CMPK1:

    Cytidine monophosphate (UMP-CMP) kinase 1, cytosolic
    Hs.731647  [show with all ESTs]
    Unigene Representative Sequence: NM_016308
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000371873(uc001cri.3 uc010omp.2 uc010omq.2) ENST00000371871
    ENST00000471289(uc001crh.2) ENST00000450808 ENST00000371870

    miRNA
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    hsa-miR-576-3p hsa-miR-520e hsa-miR-302d hsa-miR-106a hsa-miR-15a hsa-miR-29a hsa-miR-503 hsa-miR-301a
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    Inhib. RNA
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    Additional cDNA sequence: 

    AF070416.1 AF087865.1 AF110643.1 AF112216.1 AF259961.1 AK025258.1 AK223014.1 AK293238.1 
    AK294294.1 AK298502.1 AK312693.1 BC014961.1 BC017806.1 NR_046394.1 NR_046395.1 

    13 DOTS entries:

    DT.100828513  DT.452564  DT.100828511  DT.95264396  DT.91788542  DT.92444961  DT.100828510  DT.92444960 
    DT.100828517  DT.121334466  DT.40252940  DT.40301761  DT.97864628 

    24/395 AceView cDNA sequences (see all 395):

    AI224404 BQ231203 AA829372 BM983900 AA565576 CR602827 H49309 F11485 
    CR592014 F11479 CD677668 BQ773950 AA872721 CA417176 BU177199 BU684814 
    AI538268 BG400740 CA311400 AI624937 AA376858 CB132659 AI224113 AA159322 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for CMPK1    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6
    SP1:                          -                     
    SP2:                          -     -               
    SP3:                                                


    ECgene alternative splicing isoforms for CMPK1

    Expression
    for CMPK1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CMPK1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTGGCAACAT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See CMPK1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CMPK1

    SOURCE GeneReport for Unigene cluster: Hs.731647

    UniProtKB/Swiss-Prot: KCY_HUMAN, P30085
    Tissue specificity: Ubiquitously expressed

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    In Situ
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    Orthologs
    for CMPK1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CMPK1 gene from 9/35 species (see all 35)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves CMPK11 cytidine monophosphate (UMP-CMP) kinase 1, cytosolic 80.78(n)
    90.31(a)    		   429100  NM_001031564.1  NP_001026735.1 
    lizard
    (Anolis carolinensis)    		 Reptilia CMPK16
    		 --
    		 89(a)
    		 1 ↔ 1
    		 GL343249.1(1648173-1662179)
    African clawed frog
    (Xenopus laevis)    		 Amphibia MGC644742 hypothetical protein MGC64474 78.25(n)    BC045275.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.243272 Danio rerio mRNA similar to RIKEN cDNA 0610011D08 gene more 74.31(n)    BC049446.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Dak11 CG6092-PA 56.14(n)
    61.05(a)    		   43165  NM_143199.2  NP_651456.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea F40F8.11 Protein F40F8.1 57.92(n)
    59.56(a)    		   174701  NM_063985.4  NP_496386.1 
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes URA6(YKL024C)4
    URA61    		 Uridylate kinase, catalyzes the seventh enzymatic step more4
    Ura6p1    		 56.05(n)1
    51.96(a)1    		   11(393140-392526)4
    8538441, 4  NP_012901.31  NP_012901.14 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons PYR61 Uridylate kinase 55.98(n)
    54.89(a)    		   832710  NM_001036865.1  NP_001031942.1 
    rice
    (Oryza sativa)    		 Liliopsida Os.100342 Oryza sativa UMP/CMP kinase a (ura6) mRNA, complete more 71.55(n)    AF187062.1 


    ENSEMBL Gene Tree for CMPK1 (if available)
    TreeFam Gene Tree for CMPK1 (if available) 

    Paralogs
    for CMPK1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CMPK1 gene
    AK12  AK52  LOC3908772  
    4 SIMAP similar genes for CMPK1 using alignment to 4 protein entries:     KCY_HUMAN (see all proteins):
    CMPK    AK5    AK1    AK4

    CMPK1 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for CMPK1
    PGOHUM00000249186 PGOHUM00000243607


    Genomic Variants
    for CMPK1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/835 NCBI SNPs in CMPK1 are shown (see all 835)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs124030471,2
    		C,H,--47797489(+) cccccA/Caaaaa 4 -- us2k10--------
    rs39250581,2
    		C,F,A,H,--47797623(-) CTTGCT/CTTTGT 4 -- us2k130Minor allele frequency- C:0.35NS EA NA WA CSA 2778
    rs1889735681,2
    		--47797731(+) ACAACA/GAAAAG 4 -- us2k10--------
    rs1818886601,2
    		--47797864(+) TCTCCA/TGTTTG 4 -- us2k10--------
    rs1853301811,2
    		--47797882(+) TTACTA/TACGTC 4 -- us2k10--------
    rs1902075471,2
    		--47797917(+) TAGTTC/TCTTTC 4 -- us2k10--------
    rs1824813711,2
    		--47798010(+) AAAAAC/TAGGAC 4 -- us2k10--------
    rs112115171,2
    		C,F,A,H,--47798131(+) GCATCT/CATACT 4 -- us2k126Minor allele frequency- C:0.34NS EA NA WA CSA 2358
    rs1156625201,2
    		F,--47798160(+) ATACCC/TCACTG 4 -- us2k11Minor allele frequency- T:0.02WA 118
    rs799441461,2
    		F,--47798171(+) CAATCT/CTTCTT 4 -- us2k11Minor allele frequency- C:0.09WA 118

    HapMap Linkage Disequilibrium report for CMPK1 (47799469 - 47844511 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for CMPK1: --
    Human Gene Mutation Database (HGMD): CMPK1

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CMPK1
    DNA2.0 Custom Variant and Variant Library Synthesis for CMPK1

    Disorders / Diseases
    for CMPK1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CMPK1 for disorders           About GeneDecksing

    OMIM gene information: 191710    OMIM disorders: --

    10 diseases for CMPK1:    About MalaCards
    hepatitis c    tonsillitis    fibrosarcoma    alzheimer's disease
    pancreatitis    lung cancer    hepatitis    tuberculosis
    malaria    mycobacterium tuberculosis

    4 Novoseek disease relationships for CMPK1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leukemia 20 4 11494055 (1)
    pancreatic cancer 19.9 4 17000136 (4)
    tumors 0 5 17000136 (3), 8586070 (1), 15280220 (1)
    cancer 0 3 11681623 (1), 12876357 (1), 11306702 (1)


    Export disorders for CMPK1 gene to outside databases

    Publications
    for CMPK1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CMPK1 gene, integrated from 9 sources (see all 58):
    (articles sorted by number of sources associating them with CMPK1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Phosphorylation of deoxycytidine analog monophosphates by UMP-CMP kinase: molecular characterization of the human enzyme. (PubMed id 10462544)1, 2, 3, 9 Van Rompay A.R.... Karlsson A. (1999)
    2. Phosphorylation of Cytidine, Deoxycytidine, and Their Analog Monophosphates by Human UMP/CMP Kinase Is Differentially Regulated by ATP and Magnesium. (PubMed id 15550676)1, 7, 9 Hsu C.H....Cheng Y.C. (2005)
    3. Substrate-induced conformational changes in human UMP/CMP kinase. (PubMed id 15163660)1, 2, 9 Segura-Pena D.... Lavie A. (2004)
    4. Characterization of human UMP/CMP kinase and its phosphorylation of D- and L-form deoxycytidine analogue monophosphates. (PubMed id 11912132)1, 2, 9 Liou J.-Y.... Cheng Y.-C. (2002)
    5. Characterization of human UMP-CMP kinase enzymatic activity and 5' untranslated region. (PubMed id 11681623)1, 2, 9 Pearman A.T....Stafforini D.M. (2001)
    6. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PubMed id 10931946)1, 2 Hu R.-M.... Chen J.-L. (2000)
    9. Human liver protein map: update 1993. (PubMed id 8313870)1, 2 Hughes G.J.... Hochstrasser D.F. (1993)
    10. Human liver protein map: a reference database established by microsequencing and gel comparison. (PubMed id 1286669)1, 2 Hochstrasser D.F.... Hughes G.J. (1992)

    External Searches for CMPK1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing CMPK1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 51727 HGNC: 18170 AceView: UMP-CMPK Ensembl:ENSG00000162368 euGenes: HUgn51727
    ECgene: CMPK1 Kegg: 51727 H-InvDB: CMPK1

    Other Databases showing CMPK1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CMPK1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CMPK1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for CMPK1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CMPK1 gene:
    Search GeneIP for patents involving CMPK1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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