Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CMPK1 Gene

Aliases for CMPK1 Gene

  • Cytidine/Uridine Monophosphate Kinase 1 2 3
  • Cytidine Monophosphate (UMP-CMP) Kinase 1, Cytosolic 2 3 5
  • UMP/CMP Kinase 2 3 4
  • Uridine Monophosphate/Cytidine Monophosphate Kinase 3 4
  • Nucleoside-Diphosphate Kinase 3 4
  • Deoxycytidylate Kinase 3 4
  • Cytidylate Kinase 2 3
  • DCMP Kinase 3 4
  • EC 2.7.4.14 4 63
  • CMPK 3 4
  • UMPK 3 4
  • CMK 3 4
  • UMK 3 4
  • CK 3 4
  • Cytidine Monophosphate Kinase 2
  • Uridine Monophosphate Kinase 3
  • UMP-CMP Kinase 2
  • EC 2.7.4.6 4
  • UMP-CMPK 3
  • UMP/CMPK 4
  • EC 2.7.4 63
  • UCK 4

External Ids for CMPK1 Gene

Previous HGNC Symbols for CMPK1 Gene

  • CMPK

Previous GeneCards Identifiers for CMPK1 Gene

  • GC01P047572
  • GC01P047799
  • GC01P045915

Summaries for CMPK1 Gene

Entrez Gene Summary for CMPK1 Gene

  • This gene encodes one of the enzymes required for cellular nucleic acid biosynthesis. This enzyme catalyzes the transfer of a phosphate group from ATP to CMP, UMP, or dCMP, to form the corresponding diphosphate nucleotide. Alternate splicing results in both coding and non-coding transcript variants. [provided by RefSeq, Feb 2012]

GeneCards Summary for CMPK1 Gene

CMPK1 (Cytidine/Uridine Monophosphate Kinase 1) is a Protein Coding gene. Diseases associated with CMPK1 include tonsillitis and duodenitis. Among its related pathways are Metabolism and Lamivudine Pathway, Pharmacokinetics/Pharmacodynamics. GO annotations related to this gene include kinase activity and nucleobase-containing compound kinase activity. An important paralog of this gene is AK1.

UniProtKB/Swiss-Prot for CMPK1 Gene

  • Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity.

Gene Wiki entry for CMPK1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CMPK1 Gene

Genomics for CMPK1 Gene

Regulatory Elements for CMPK1 Gene

Promoters for CMPK1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CMPK1 on UCSC Golden Path with GeneCards custom track

Genomic Location for CMPK1 Gene

Chromosome:
1
Start:
47,333,797 bp from pter
End:
47,378,839 bp from pter
Size:
45,043 bases
Orientation:
Plus strand

Genomic View for CMPK1 Gene

Genes around CMPK1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CMPK1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CMPK1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CMPK1 Gene

Proteins for CMPK1 Gene

  • Protein details for CMPK1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P30085-KCY_HUMAN
    Recommended name:
    UMP-CMP kinase
    Protein Accession:
    P30085
    Secondary Accessions:
    • B4DPU7
    • E9PGI8
    • Q53GB7
    • Q5SVZ0
    • Q96C07
    • Q9UBQ8
    • Q9UIA2

    Protein attributes for CMPK1 Gene

    Size:
    196 amino acids
    Molecular mass:
    22222 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Monomer.
    SequenceCaution:
    • Sequence=AAF17709.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAH14961.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAD96734.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAG60709.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAI13471.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI14972.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CMPK1 Gene

    Alternative splice isoforms for CMPK1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CMPK1 Gene

Proteomics data for CMPK1 Gene at MOPED

Post-translational modifications for CMPK1 Gene

  • Ubiquitination at Lys 26, Lys 43, Lys 88, and Lys 106
  • Modification sites at PhosphoSitePlus

Other Protein References for CMPK1 Gene

Domains & Families for CMPK1 Gene

Protein Domains for CMPK1 Gene

Graphical View of Domain Structure for InterPro Entry

P30085

UniProtKB/Swiss-Prot:

KCY_HUMAN :
  • Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
  • Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.
Domain:
  • Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
Family:
  • Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.
genes like me logo Genes that share domains with CMPK1: view

No data available for Gene Families for CMPK1 Gene

Function for CMPK1 Gene

Molecular function for CMPK1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + (d)CMP = ADP + (d)CDP.
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + UMP = ADP + UDP.
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + nucleoside diphosphate = ADP + nucleoside triphosphate.
UniProtKB/Swiss-Prot Function:
Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity.

Enzyme Numbers (IUBMB) for CMPK1 Gene

Gene Ontology (GO) - Molecular Function for CMPK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
GO:0009041 uridylate kinase activity IEA --
genes like me logo Genes that share ontologies with CMPK1: view
genes like me logo Genes that share phenotypes with CMPK1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CMPK1

CRISPR Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CMPK1 Gene

Localization for CMPK1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CMPK1 Gene

Nucleus. Cytoplasm. Note=Predominantly cytoplasmic, less than 15% nuclear. {ECO:0000269 PubMed:11912132}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CMPK1 Gene COMPARTMENTS Subcellular localization image for CMPK1 gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 5
mitochondrion 2
endoplasmic reticulum 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CMPK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm TAS 10462544
genes like me logo Genes that share ontologies with CMPK1: view

Pathways & Interactions for CMPK1 Gene

genes like me logo Genes that share pathways with CMPK1: view

Gene Ontology (GO) - Biological Process for CMPK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006221 pyrimidine nucleotide biosynthetic process IEA --
GO:0006222 UMP biosynthetic process TAS 10462544
GO:0009220 pyrimidine ribonucleotide biosynthetic process TAS 10462544
GO:0016310 phosphorylation IEA --
GO:0046940 nucleoside monophosphate phosphorylation EXP 40615
genes like me logo Genes that share ontologies with CMPK1: view

No data available for SIGNOR curated interactions for CMPK1 Gene

Drugs & Compounds for CMPK1 Gene

(18) Drugs for CMPK1 Gene - From: HMDB, Novoseek, DrugBank, FDA Approved Drugs, and PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Gemcitabine Approved Pharma Target, inhibitor Ribonucleotide reductase and DNA synthesis inhibitor, Nucleoside Analogs 1881
Lamivudine Approved, Investigational Pharma Enzyme, substrate Nucleoside analog reverse transcriptase inhibitor 594
Gemzar Approved May 1996 Pharma 0
Adenosine triphosphate Approved Nutra 0
Uridine-5'-Diphosphate Experimental Pharma Target 0

(12) Additional Compounds for CMPK1 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
Cytidine monophosphate
  • 5'-CMP
  • 5-Cytidylate
  • 5-Cytidylic acid
  • CMP
  • Cytidine 5'-monophosphate
63-37-6
dcdp
  • 2'-Deoxy-Cytidine 5'-pyrophosphate
  • 2'-Deoxy-Cytidine pyrophosphate
  • 2'-Deoxycytidine 5'-diphosphate
  • 2'-Deoxycytidine diphosphate
  • 2'-Deoxycytidine-5'-diphosphate
800-73-7
genes like me logo Genes that share compounds with CMPK1: view

Transcripts for CMPK1 Gene

Unigene Clusters for CMPK1 Gene

Cytidine monophosphate (UMP-CMP) kinase 1, cytosolic:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CMPK1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6
SP1: -
SP2: - -
SP3:

Relevant External Links for CMPK1 Gene

GeneLoc Exon Structure for
CMPK1
ECgene alternative splicing isoforms for
CMPK1

Expression for CMPK1 Gene

mRNA expression in normal human tissues for CMPK1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CMPK1 Gene

This gene is overexpressed in Salivary gland (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CMPK1 Gene



SOURCE GeneReport for Unigene cluster for CMPK1 Gene Hs.731647

mRNA Expression by UniProt/SwissProt for CMPK1 Gene

P30085-KCY_HUMAN
Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expression patterns with CMPK1: view

Protein tissue co-expression partners for CMPK1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for CMPK1 Gene

Orthologs for CMPK1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CMPK1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CMPK1 36
  • 99 (a)
OneToOne
CMPK1 35
  • 99.42 (n)
  • 99.12 (a)
cow
(Bos Taurus)
Mammalia CMPK1 36
  • 97 (a)
OneToOne
CMPK1 35
  • 92.4 (n)
  • 92.11 (a)
dog
(Canis familiaris)
Mammalia CMPK1 35
  • 93.71 (n)
  • 93.42 (a)
CMPK1 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cmpk1 36
  • 91 (a)
OneToOne
Cmpk1 35
  • 90.31 (n)
  • 91.19 (a)
Cmpk1 16
oppossum
(Monodelphis domestica)
Mammalia CMPK1 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CMPK1 36
  • 79 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cmpk1 35
  • 90.46 (n)
  • 90.31 (a)
chicken
(Gallus gallus)
Aves CMPK1 35
  • 80.78 (n)
  • 90.31 (a)
CMPK 36
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CMPK1 36
  • 82 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC64474 35
tropical clawed frog
(Silurana tropicalis)
Amphibia cmpk1 35
  • 74.75 (n)
  • 82.83 (a)
zebrafish
(Danio rerio)
Actinopterygii cmpk 35
  • 66.05 (n)
  • 71.3 (a)
Dr.24327 35
cmpk 36
  • 67 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003968 35
  • 57.95 (n)
  • 60 (a)
fruit fly
(Drosophila melanogaster)
Insecta Dak1 35
  • 56.14 (n)
  • 61.05 (a)
Dak1 36
  • 46 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea C29F7.3 36
  • 54 (a)
OneToMany
F40F8.1 36
  • 57 (a)
OneToMany
F40F8.1 35
  • 57.92 (n)
  • 59.56 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACR170C 35
  • 50.84 (n)
  • 50.28 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes URA6 35
  • 56.05 (n)
  • 51.96 (a)
URA6 36
  • 46 (a)
OneToMany
URA6 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E08053g 35
  • 54.76 (n)
  • 50.55 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons PYR6 35
  • 55.86 (n)
  • 54.59 (a)
rice
(Oryza sativa)
Liliopsida Os.10034 35
Os07g0624700 35
  • 56.54 (n)
  • 54.7 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU02812 35
  • 52.12 (n)
  • 50.83 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPCC1795.05c 35
  • 52.85 (n)
  • 49.17 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4162 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 62 (a)
OneToOne
Species with no ortholog for CMPK1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CMPK1 Gene

ENSEMBL:
Gene Tree for CMPK1 (if available)
TreeFam:
Gene Tree for CMPK1 (if available)

Paralogs for CMPK1 Gene

Paralogs for CMPK1 Gene

(3) SIMAP similar genes for CMPK1 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for CMPK1 Gene

genes like me logo Genes that share paralogs with CMPK1: view

Variants for CMPK1 Gene

Sequence variations from dbSNP and Humsavar for CMPK1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs6795 -- 47,378,792(+) TATCA(A/G)TTATT nc-transcript-variant, utr-variant-3-prime
rs1044457 -- 47,377,105(+) ATACC(A/C/T)GCTTC nc-transcript-variant, utr-variant-3-prime
rs2245850 -- 47,357,478(-) agaaT(C/G)CATTA intron-variant
rs2246708 -- 47,364,985(-) tcaga(A/C/T)gctca intron-variant
rs2250183 -- 47,371,130(-) GCTTC(A/G)GCCAT intron-variant

Variation tolerance for CMPK1 Gene

Residual Variation Intolerance Score: 64.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.72; 66.29% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CMPK1 Gene

HapMap Linkage Disequilibrium report
CMPK1
Human Gene Mutation Database (HGMD)
CMPK1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CMPK1 Gene

Disorders for CMPK1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for CMPK1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
tonsillitis
  • chronic tonsillitis
duodenitis
  • hemorrhagic duodenitis
- elite association - COSMIC cancer census association via MalaCards
Search CMPK1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CMPK1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CMPK1
genes like me logo Genes that share disorders with CMPK1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CMPK1 Gene

Publications for CMPK1 Gene

  1. Phosphorylation of deoxycytidine analog monophosphates by UMP-CMP kinase: molecular characterization of the human enzyme. (PMID: 10462544) Van Rompay A.R. … Karlsson A. (Mol. Pharmacol. 1999) 2 3 4 23 67
  2. Phosphorylation of Cytidine, Deoxycytidine, and Their Analog Monophosphates by Human UMP/CMP Kinase Is Differentially Regulated by ATP and Magnesium. (PMID: 15550676) Hsu C.H. … Cheng Y.C. (Mol. Pharmacol. 2005) 3 23 25 26
  3. The impact of hypoxic treatment on the expression of phosphoglycerate kinase and the cytotoxicity of troxacitabine and gemcitabine. (PMID: 17565005) Lam W. … Cheng Y.C. (Mol. Pharmacol. 2007) 23 25 26
  4. Gene therapy based on gemcitabine chemosensitization suppresses pancreatic tumor growth. (PMID: 17000136) Vernejoul F. … Tiraby G. (Mol. Ther. 2006) 23 25 26
  5. Genetic factors influencing pyrimidine-antagonist chemotherapy. (PMID: 16041392) Maring J.G. … de Vries E.G. (Pharmacogenomics J. 2005) 23 25 26

Products for CMPK1 Gene

Sources for CMPK1 Gene

Back to Top

Content