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CMPK1 Gene

protein-coding   GIFtS: 58
GCID: GC01P047799

Cytidine Monophosphate (UMP-CMP) Kinase 1, Cytosolic

(Previous name: cytidylate kinase)
(Previous symbol: CMPK)
  Search for CMPK1
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cytidine Monophosphate (UMP-CMP) Kinase 1, Cytosolic1 2     DCMP Kinase2 3
CMPK1 2 3 5     UMP/CMP Kinase2 3
CMK2 3 5     EC 2.7.4.143 8
UMK2 3 5     Cytidine Monophosphate Kinase1
UMPK2 3 5     UMP-CMPK2
Cytidylate Kinase1 2     Uridine Monophosphate Kinase2
UMP-CMP Kinase1 2     EC 2.7.4.63
Deoxycytidylate Kinase2 3     UCK3
Nucleoside-Diphosphate Kinase2 3     UMP/CMPK3
Uridine Monophosphate/Cytidine Monophosphate Kinase2 3     EC 2.7.48
CK2 3     

External Ids:    HGNC: 181701   Entrez Gene: 517272   Ensembl: ENSG000001623687   OMIM: 1917105   UniProtKB: P300853   

Export aliases for CMPK1 gene to outside databases

Previous GC identifers: GC01P047572 GC01P045915


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CMPK1 Gene:
This gene encodes one of the enzymes required for cellular nucleic acid biosynthesis. This enzyme catalyzes the
transfer of a phosphate group from ATP to CMP, UMP, or dCMP, to form the corresponding diphosphate nucleotide.
Alternate splicing results in both coding and non-coding transcript variants. (provided by RefSeq, Feb 2012)

GeneCards Summary for CMPK1 Gene:
CMPK1 (cytidine monophosphate (UMP-CMP) kinase 1, cytosolic) is a protein-coding gene. GO annotations related to this gene include nucleoside diphosphate kinase activity and cytidylate kinase activity. An important paralog of this gene is AK1.

UniProtKB/Swiss-Prot: KCY_HUMAN, P30085
Function: Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an
important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate
acceptors. Also displays broad nucleoside diphosphate kinase activity

Gene Wiki entry for CMPK1 (CMPK) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the CMPK1 gene promoter:
         E2F-3a   E2F-4   E2F-5   E2F-2   RORalpha2   c-Rel   E2F-1   E2F   FOXC1   c-Myb   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCMPK1 promoter sequence
   Search Chromatin IP Primers for CMPK1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CMPK1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p32   Ensembl cytogenetic band:  1p33   HGNC cytogenetic band: 1p34.1-p33

CMPK1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CMPK1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P047799:  view genomic region     (about GC identifiers)

Start:
47,799,469 bp from pter      End:
47,844,511 bp from pter
Size:
45,043 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: KCY_HUMAN, P30085 (See protein sequence)
Recommended Name: UMP-CMP kinase  
Size: 196 amino acids; 22222 Da
Cofactor: Binds 1 magnesium ion per monomer
Subunit: Monomer (By similarity)
Sequence caution: Sequence=AAF17709.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=AAH14961.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=BAD96734.1;
Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=BAG60709.1; Type=Erroneous
initiation; Note=Translation N-terminally shortened; Sequence=CAI13471.1; Type=Erroneous gene model prediction;
Sequence=CAI14972.1; Type=Erroneous gene model prediction;
1 PDB 3D structure from and Proteopedia for CMPK1:
1TEV (3D)    
Secondary accessions: B4DPU7 E9PGI8 Q53GB7 Q5SVZ0 Q96C07 Q9UBQ8 Q9UIA2
Alternative splicing: 2 isoforms:  P30085-1   P30085-2   

Explore the universe of human proteins at neXtProt for CMPK1: NX_P30085

Explore proteomics data for CMPK1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys26, Lys43, Lys55, Lys88, Lys106
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for CMPK1 (P30085) (see all 14)
     MDGKADV  SGRSDDN  LLRDERK  SQYGELI 


    See CMPK1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001129612.1  NP_057392.1  

    ENSEMBL proteins: 
     ENSP00000360939   ENSP00000360937   ENSP00000433782   ENSP00000398192  
    Reactome Protein details: P30085

    CMPK1 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR000850 Adenylat/UMP-CMP_kin
     IPR006266 UMP_CMP_kinase
     IPR027417 P-loop_NTPase

    Graphical View of Domain Structure for InterPro Entry P30085

    ProtoNet protein and cluster: P30085

    1 Blocks protein domain: IPB000850 Adenylate kinase

    UniProtKB/Swiss-Prot: KCY_HUMAN, P30085
    Domain: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID,
    which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP
    binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to
    prevent ATP hydrolysis
    Similarity: Belongs to the adenylate kinase family. UMP-CMP kinase subfamily


    Find genes that share domains with CMPK1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KCY_HUMAN, P30085
    Function: Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an
    important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate
    acceptors. Also displays broad nucleoside diphosphate kinase activity
    Catalytic activity: ATP + (d)CMP = ADP + (d)CDP
    Catalytic activity: ATP + UMP = ADP + UDP
    Catalytic activity: ATP + nucleoside diphosphate = ADP + nucleoside triphosphate

         Enzyme Numbers (IUBMB): EC 2.7.4.141 2 EC 2.7.4.61 EC 2.7.42

         Gene Ontology (GO): Selected molecular function terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004127cytidylate kinase activity IEA--
    GO:0004550nucleoside diphosphate kinase activity IDA--
    GO:0004849uridine kinase activity TAS10462544
    GO:0005524ATP binding IEA--
    GO:0016301kinase activity ----
         
    Find genes that share ontologies with CMPK1           About GenesLikeMe


    Phenotypes:
         1 MGI phenotypic allele for Cmpk1 (no phenotypes)

    Find genes that share phenotypes with CMPK1           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CMPK1
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    miRTarBase miRNAs that target CMPK1:
    hsa-mir-484 (MIRT042359), hsa-mir-192-5p (MIRT026115), hsa-mir-10a-5p (MIRT025611), hsa-mir-34a-5p (MIRT025229), hsa-mir-16-5p (MIRT031434), hsa-mir-26b-5p (MIRT028815), hsa-mir-590-3p (MIRT016177), hsa-mir-215-5p (MIRT024406), hsa-mir-374b-5p (MIRT016049)

    Block miRNA regulation of human, mouse, rat CMPK1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CMPK1 (see all 57):
    hsa-miR-576-3p hsa-miR-520e hsa-miR-302d hsa-miR-106a hsa-miR-15a hsa-miR-29a hsa-miR-503 hsa-miR-301a
    SwitchGear 3'UTR luciferase reporter plasmidCMPK1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CMPK1

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    Sino Biological Human cDNA Clone for CMPK1
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    Addgene plasmids for CMPK1 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CMPK1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    KCY_HUMAN, P30085: Nucleus. Cytoplasm. Note=Predominantly nuclear
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    mitochondrion2
    endoplasmic reticulum1
    extracellular1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730nucleolus IDA--
    GO:0005737cytoplasm TAS10462544
    GO:0005829cytosol TAS--
    GO:0070062extracellular vesicular exosome IDA19056867

    Find genes that share ontologies with CMPK1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CMPK1 About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1Metabolism
    Metabolism0.38
    Metabolic pathways0.38
    2superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis
    superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis0.52
    superpathway of pyrimidine ribonucleotides de novo biosynthesis0.00
    superpathway of pyrimidine deoxyribonucleoside salvage0.46
    pyrimidine deoxyribonucleotide phosphorylation0.00
    UTP and CTP de novo biosynthesis0.00
    3Purine metabolism (REACTOME)
    Metabolism of nucleotides0.42
    Synthesis and interconversion of nucleotide di- and triphosphates0.00
    4Purine metabolism (KEGG)
    Pyrimidine metabolism0.38
    5Lamivudine Pathway, Pharmacokinetics/Pharmacodynamics
    Lamivudine Pathway, Pharmacokinetics/Pharmacodynamics


    Find genes that share SuperPaths with CMPK1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    5 BioSystems Pathways for CMPK1
        superpathway of pyrimidine ribonucleotides de novo biosynthesis
    superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis
    pyrimidine deoxyribonucleotide phosphorylation
    superpathway of pyrimidine deoxyribonucleoside salvage
    UTP and CTP de novo biosynthesis


    1 Reactome Pathway for CMPK1
        Synthesis and interconversion of nucleotide di- and triphosphates

    2 PharmGKB Pathways for CMPK1
        Gemcitabine Pathway, Pharmacodynamics
    Lamivudine Pathway, Pharmacokinetics/Pharmacodynamics

    2 Kegg Pathways  (Kegg details for CMPK1):
        Pyrimidine metabolism
    Metabolic pathways

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CMPK1
    Interactions:

        Search GeneGlobe Interaction Network for CMPK1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CMPK1 (P300852, 3 ENSP000003609394) via UniProtKB, MINT, STRING, and/or I2D (see all 78)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YWHAZP631042, 3, ENSP000003095034MINT-3296474 I2D: score=1 STRING: ENSP00000309503
    BACE1P568173, ENSP000003185854I2D: score=2 STRING: ENSP00000318585
    AK2P548193, ENSP000003469214I2D: score=1 STRING: ENSP00000346921
    DTYMKP239193, ENSP000003048024I2D: score=1 STRING: ENSP00000304802
    EIF6P565373, ENSP000003635594I2D: score=1 STRING: ENSP00000363559
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006139nucleobase-containing compound metabolic process ----
    GO:0006165nucleoside diphosphate phosphorylation IDA--
    GO:0006222UMP biosynthetic process TAS10462544
    GO:0006225UDP biosynthetic process IEA--
    GO:0006227dUDP biosynthetic process IEA--

    Find genes that share ontologies with CMPK1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CMPK1 (KCY)

    1 HMDB Compound for CMPK1    About this table
    CompoundSynonyms CAS #PubMed Ids
    MagnesiumMagnesium (see all 2)7439-95-4--

    7 DrugBank Compounds for CMPK1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    GemcitabinedFdC (see all 4)95058-81-4targetinhibitor16041392 17000136 17565005 15550676
    Adenosine-5'-Diphosphate-- 20398-34-9target--17139284 17016423 10592235
    Cytidine-5'-Monophosphate-- 84-52-6target--17139284 17016423 10592235
    P1-(Adenosine-5'-P5-(Uridine-5')Pentaphosphate-- --target--17139284 17016423 10592235
    Tetrafluoroaluminate Ion-- --target--17139284 17016423 10592235
    Uridine-5'-Diphosphate-- 58-98-0target--17139284 17016423 10592235
    Lamivudine-- 134678-17-4enzymesubstrate19887088 15963349

    Selected Novoseek inferred chemical compound relationships for CMPK1 gene (see all 17)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    dcmp 93 16 15550676 (4), 10462544 (1), 18343960 (1), 19181797 (1) (see all 10)
    nucleoside monophosphate 90.4 1 12694191 (1)
    poly c 83.8 19 18343960 (3), 8586070 (1), 19876400 (1), 19765547 (1) (see all 7)
    deoxycytidine 82.5 7 10462544 (2), 11912132 (1), 19876400 (1), 19765547 (1) (see all 5)
    triphosphate 75.5 1 17101674 (1)
    cytidine 73.5 8 15130468 (3), 15280220 (1), 11494055 (1), 12876357 (1)
    ctp 70.6 2 12694191 (1), 15130468 (1)
    pyrimidine 69.3 5 15550676 (2), 19765547 (1)
    uridine 68.9 10 15130468 (2), 15280220 (1), 11494055 (1), 12876357 (1) (see all 5)
    poly u 66.5 5 10218107 (1), 16041392 (1), 17000136 (1)

    1 PharmGKB related drug/compound annotation for CMPK1 gene    About this table
    Drug/compound PharmGKB Annotation
    gemcitabineCA  



    Find genes that share compounds with CMPK1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CMPK1 gene (2 alternative transcripts): 
    NM_001136140.1  NM_016308.2  

    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000371873(uc001cri.3 uc010omp.2 uc010omq.2) ENST00000371871
    ENST00000471289(uc001crh.2) ENST00000450808 ENST00000371870
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    hsa-miR-576-3p hsa-miR-520e hsa-miR-302d hsa-miR-106a hsa-miR-15a hsa-miR-29a hsa-miR-503 hsa-miR-301a
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      QuantiTect SYBR Green Assays in human, mouse, rat CMPK1
      QuantiFast Probe-based Assays in human, mouse, rat CMPK1

    Selected AceView cDNA sequences (see all 395):

    BQ231203 CB132659 AA338017 AA313927 AA227335 AA376858 H49309 CA417176 
    AA565576 CA311400 CR602827 BQ215729 AA872721 BU177199 AA159322 BU952244 
    BG400740 CB123093 AA037721 AI417131 BU684814 CK430971 F11485 CR592014 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for CMPK1    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6
    SP1:                          -                     
    SP2:                          -     -               
    SP3:                                                


    ECgene alternative splicing isoforms for CMPK1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    CMPK1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTGGCAACAT
    CMPK1 Expression
    About this image

    CMPK1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CMPK1 Protein Expression

    UniProtKB/Swiss-Prot: KCY_HUMAN, P30085
    Tissue specificity: Ubiquitously expressed

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CMPK1 gene from Selected species (see all 25)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cmpk11 , 5 cytidine monophosphate (UMP-CMP) kinase 11, 5 90.31(n)1
    91.19(a)1
      4 (52.73 cM)5
    665881  NM_025647.31  NP_079923.31 
     1149593365 
    chicken
    (Gallus gallus)
    Aves CMPK11 cytidine monophosphate (UMP-CMP) kinase 1, cytosolic 80.78(n)
    90.31(a)
      429100  NM_001031564.1  NP_001026735.1 
    lizard
    (Anolis carolinensis)
    Reptilia CMPK16
    cytidine monophosphate (UMP-CMP) kinase 1, cytosol...
    82(a)
    1 ↔ 1
    GL343249.1(1643695-1662904)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC644742 hypothetical protein MGC64474 78.25(n)    BC045275.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.243272 Danio rerio mRNA similar to RIKEN cDNA 0610011D08 gene more 74.31(n)    BC049446.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Dak11 Dak1 56.14(n)
    61.05(a)
      43165  NM_143199.3  NP_651456.1 
    worm
    (Caenorhabditis elegans)
    Secernentea F40F8.11 F40F8.1 57.92(n)
    59.56(a)
      174701  NM_063985.5  NP_496386.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes URA6(YKL024C)4
    URA61
    Uridylate kinase, catalyzes the seventh enzymatic step more4
    URA61
    56.05(n)1
    51.96(a)1
      11(393140-392526)4
    8538441, 4  NP_012901.31  NP_012901.14 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons PYR61 PYR6 55.86(n)
    54.59(a)
      832710  NM_180536.2  NP_850867.1 
    rice
    (Oryza sativa)
    Liliopsida Os.100342 Oryza sativa UMP/CMP kinase a (ura6) mRNA, complete more 71.55(n)    AF187062.1 


    ENSEMBL Gene Tree for CMPK1 (if available)
    TreeFam Gene Tree for CMPK1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CMPK1 gene
    AK12  AK52  
    3 SIMAP similar genes for CMPK1 using alignment to 3 protein entries:     KCY_HUMAN (see all proteins):
    CMPK    AK1    AK5

    Find genes that share paralogs with CMPK1           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for CMPK1
    PGOHUM00000249186 PGOHUM00000243607


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CMPK1 (see all 986)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs124030471,2
    C,F,H--47797489(+) cccccA/Caaaaa 4 -- us2k10--------
    rs39250581,2
    C,F,A,H--47797623(-) cttgcT/Ctttgt 4 -- us2k130Minor allele frequency- C:0.35NS EA NA WA CSA 2778
    rs1889735681,2
    --47797731(+) ACAACA/GAAAAG 4 -- us2k10--------
    rs1818886601,2
    --47797864(+) TCTCCA/TGTTTG 4 -- us2k10--------
    rs1853301811,2
    C--47797882(+) TTACTA/TACGTC 4 -- us2k10--------
    rs1902075471,2
    --47797917(+) TAGTTC/TCTTTC 4 -- us2k10--------
    rs1824813711,2
    --47798010(+) AAAAAC/TAGGAC 4 -- us2k10--------
    rs112115171,2
    C,F,A,H--47798131(+) gcatcT/Catact 4 -- us2k126Minor allele frequency- C:0.34NS EA NA WA CSA 2358
    rs1156625201,2
    F--47798160(+) ATACCC/TCACTG 4 -- us2k11Minor allele frequency- T:0.02WA 118
    rs799441461,2
    C,F--47798171(+) CAATCT/CTTCTT 4 -- us2k11Minor allele frequency- C:0.09WA 118

    HapMap Linkage Disequilibrium report for CMPK1 (47799469 - 47844511 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for CMPK1: --
    Human Gene Mutation Database (HGMD): CMPK1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CMPK1
    DNA2.0 Custom Variant and Variant Library Synthesis for CMPK1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 191710    OMIM disorders: --


    Find genes that share disorders with CMPK1           About GenesLikeMe

    4 Novoseek inferred disease relationships for CMPK1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leukemia 20 4 11494055 (1)
    pancreatic cancer 19.9 4 17000136 (4)
    tumors 0 5 17000136 (3), 8586070 (1), 15280220 (1)
    cancer 0 3 11681623 (1), 12876357 (1), 11306702 (1)


    Export disorders for CMPK1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CMPK1 gene, integrated from 10 sources (see all 65):
    (articles sorted by number of sources associating them with CMPK1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Phosphorylation of deoxycytidine analog monophosphates by UMP-CMP kinase: molecular characterization of the human enzyme. (PubMed id 10462544)1, 2, 3, 9 Van Rompay A.R.... Karlsson A. (Mol. Pharmacol. 1999)
    2. Phosphorylation of Cytidine, Deoxycytidine, and Their Analog Monophosphates by Human UMP/CMP Kinase Is Differentially Regulated by ATP and Magnesium. (PubMed id 15550676)1, 7, 9 Hsu C.H....Cheng Y.C. (Mol. Pharmacol. 2005)
    3. Substrate-induced conformational changes in human UMP/CMP kinase. (PubMed id 15163660)1, 2, 9 Segura-Pena D.... Lavie A. (J. Biol. Chem. 2004)
    4. Characterization of human UMP/CMP kinase and its phosphorylation of D- and L-form deoxycytidine analogue monophosphates. (PubMed id 11912132)1, 2, 9 Liou J.-Y.... Cheng Y.-C. (Cancer Res. 2002)
    5. Characterization of human UMP-CMP kinase enzymatic activity and 5' untranslated region. (PubMed id 11681623)1, 2, 9 Pearman A.T....Stafforini D.M. (Life Sci. 2001)
    6. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PubMed id 10931946)1, 2 Hu R.-M.... Chen J.-L. (Proc. Natl. Acad. Sci. U.S.A. 2000)
    9. Human liver protein map: update 1993. (PubMed id 8313870)1, 2 Hughes G.J.... Hochstrasser D.F. (Electrophoresis 1993)
    10. Human liver protein map: a reference database established by microsequencing and gel comparison. (PubMed id 1286669)1, 2 Hochstrasser D.F.... Hughes G.J. (Electrophoresis 1992)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 51727 HGNC: 18170 AceView: UMP-CMPK Ensembl:ENSG00000162368 euGenes: HUgn51727
    ECgene: CMPK1 Kegg: 51727 H-InvDB: CMPK1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CMPK1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CMPK1 gene:
    Search GeneIP for patents involving CMPK1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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