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Aliases for CMPK1 Gene

Aliases for CMPK1 Gene

  • Cytidine Monophosphate (UMP-CMP) Kinase 1, Cytosolic 2 3
  • UMPK 3 4 6
  • CMPK 3 4 6
  • CMK 3 4 6
  • UMK 3 4 6
  • Uridine Monophosphate/Cytidine Monophosphate Kinase 3 4
  • Nucleoside-Diphosphate Kinase 3 4
  • Deoxycytidylate Kinase 3 4
  • Cytidylate Kinase 2 3
  • UMP-CMP Kinase 2 3
  • UMP/CMP Kinase 3 4
  • DCMP Kinase 3 4
  • EC 2.7.4.14 4 63
  • CK 3 4
  • Cytidine Monophosphate Kinase 2
  • Uridine Monophosphate Kinase 3
  • EC 2.7.4.6 4
  • UMP-CMPK 3
  • UMP/CMPK 4
  • EC 2.7.4 63
  • UCK 4

External Ids for CMPK1 Gene

Previous HGNC Symbols for CMPK1 Gene

  • CMPK

Previous GeneCards Identifiers for CMPK1 Gene

  • GC01P047572
  • GC01P047799
  • GC01P045915

Summaries for CMPK1 Gene

Entrez Gene Summary for CMPK1 Gene

  • This gene encodes one of the enzymes required for cellular nucleic acid biosynthesis. This enzyme catalyzes the transfer of a phosphate group from ATP to CMP, UMP, or dCMP, to form the corresponding diphosphate nucleotide. Alternate splicing results in both coding and non-coding transcript variants. [provided by RefSeq, Feb 2012]

GeneCards Summary for CMPK1 Gene

CMPK1 (Cytidine Monophosphate (UMP-CMP) Kinase 1, Cytosolic) is a Protein Coding gene. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include nucleoside diphosphate kinase activity and cytidylate kinase activity. An important paralog of this gene is AK1.

UniProtKB/Swiss-Prot for CMPK1 Gene

  • Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity.

Gene Wiki entry for CMPK1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CMPK1 Gene

Genomics for CMPK1 Gene

Regulatory Elements for CMPK1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CMPK1 Gene

Start:
47,333,797 bp from pter
End:
47,378,839 bp from pter
Size:
45,043 bases
Orientation:
Plus strand

Genomic View for CMPK1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CMPK1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CMPK1 Gene

Proteins for CMPK1 Gene

  • Protein details for CMPK1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P30085-KCY_HUMAN
    Recommended name:
    UMP-CMP kinase
    Protein Accession:
    P30085
    Secondary Accessions:
    • B4DPU7
    • E9PGI8
    • Q53GB7
    • Q5SVZ0
    • Q96C07
    • Q9UBQ8
    • Q9UIA2

    Protein attributes for CMPK1 Gene

    Size:
    196 amino acids
    Molecular mass:
    22222 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Note=Binds 1 Mg(2+) ion per monomer.;
    Quaternary structure:
    • Monomer.
    SequenceCaution:
    • Sequence=AAF17709.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAH14961.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAD96734.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAG60709.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAI13471.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI14972.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CMPK1 Gene

    Alternative splice isoforms for CMPK1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CMPK1 Gene

Proteomics data for CMPK1 Gene at MOPED

Post-translational modifications for CMPK1 Gene

  • Ubiquitination at Lys26, Lys43, Lys55, Lys88, and Lys106
  • Modification sites at PhosphoSitePlus

Other Protein References for CMPK1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for CMPK1 Gene

Protein Domains for CMPK1 Gene

Suggested Antigen Peptide Sequences for CMPK1 Gene

Graphical View of Domain Structure for InterPro Entry

P30085

UniProtKB/Swiss-Prot:

KCY_HUMAN :
  • P30085
Domain:
  • Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis
Family:
  • Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.
genes like me logo Genes that share domains with CMPK1: view

No data available for Gene Families for CMPK1 Gene

Function for CMPK1 Gene

Molecular function for CMPK1 Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + (d)CMP = ADP + (d)CDP.
UniProtKB/Swiss-Prot CatalyticActivity: ATP + UMP = ADP + UDP.
UniProtKB/Swiss-Prot CatalyticActivity: ATP + nucleoside diphosphate = ADP + nucleoside triphosphate.
UniProtKB/Swiss-Prot Function: Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity.

Enzyme Numbers (IUBMB) for CMPK1 Gene

Gene Ontology (GO) - Molecular Function for CMPK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004127 cytidylate kinase activity IEA --
GO:0004550 nucleoside diphosphate kinase activity IDA 23416111
GO:0004849 uridine kinase activity TAS 10462544
GO:0005524 ATP binding IEA --
GO:0009041 uridylate kinase activity --
genes like me logo Genes that share ontologies with CMPK1: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CMPK1

In Situ Assay Products

Flow Cytometry Products

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for CMPK1 Gene

Localization for CMPK1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CMPK1 Gene

Nucleus. Cytoplasm. Note=Predominantly nuclear.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CMPK1 Gene COMPARTMENTS Subcellular localization image for CMPK1 gene
Compartment Confidence
nucleus 5
cytosol 4
mitochondrion 2
endoplasmic reticulum 1
extracellular 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CMPK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm TAS 10462544
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with CMPK1: view

Pathways for CMPK1 Gene

genes like me logo Genes that share pathways with CMPK1: view

Gene Ontology (GO) - Biological Process for CMPK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006139 nucleobase-containing compound metabolic process --
GO:0006165 nucleoside diphosphate phosphorylation IDA 23416111
GO:0006207 de novo pyrimidine nucleobase biosynthetic process IEA --
GO:0006221 pyrimidine nucleotide biosynthetic process --
GO:0006222 UMP biosynthetic process TAS 10462544
genes like me logo Genes that share ontologies with CMPK1: view

Compounds for CMPK1 Gene

(1) HMDB Compounds for CMPK1 Gene

Compound Synonyms Cas Number PubMed IDs
Magnesium
  • Magnesium
7439-95-4

(7) Drugbank Compounds for CMPK1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Adenosine-5'-Diphosphate
20398-34-9 target
Cytidine-5'-Monophosphate
84-52-6 target
Gemcitabine
  • dFdC
95058-81-4 target inhibitor
Lamivudine
134678-17-4 enzyme substrate
P1-(Adenosine-5'-P5-(Uridine-5')Pentaphosphate
target

(17) Novoseek inferred chemical compound relationships for CMPK1 Gene

Compound -log(P) Hits PubMed IDs
dcmp 93 13
nucleoside monophosphate 90.4 1
poly c 83.8 9
deoxycytidine 82.5 6
triphosphate 75.5 1

(1) PharmGKB related drug/compound annotations for CMPK1 Gene

Drug/compound Annotation
gemcitabine CA
genes like me logo Genes that share compounds with CMPK1: view

Transcripts for CMPK1 Gene

Unigene Clusters for CMPK1 Gene

Cytidine monophosphate (UMP-CMP) kinase 1, cytosolic:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CMPK1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CMPK1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6
SP1: -
SP2: - -
SP3:

Relevant External Links for CMPK1 Gene

GeneLoc Exon Structure for
CMPK1
ECgene alternative splicing isoforms for
CMPK1

Expression for CMPK1 Gene

mRNA expression in normal human tissues for CMPK1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CMPK1 Gene

SOURCE GeneReport for Unigene cluster for CMPK1 Gene Hs.731647

mRNA Expression by UniProt/SwissProt for CMPK1 Gene

P30085-KCY_HUMAN
Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expressions with CMPK1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for CMPK1 Gene

Orthologs for CMPK1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CMPK1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CMPK1 35
  • 99.42 (n)
  • 99.12 (a)
CMPK1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CMPK1 35
  • 92.4 (n)
  • 92.11 (a)
CMPK1 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CMPK1 35
  • 93.71 (n)
  • 93.42 (a)
CMPK1 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cmpk1 35
  • 90.31 (n)
  • 91.19 (a)
Cmpk1 16
Cmpk1 36
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CMPK1 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CMPK1 36
  • 79 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cmpk1 35
  • 90.46 (n)
  • 90.31 (a)
chicken
(Gallus gallus)
Aves CMPK 36
  • 80 (a)
OneToOne
CMPK1 35
  • 80.78 (n)
  • 90.31 (a)
lizard
(Anolis carolinensis)
Reptilia CMPK1 36
  • 82 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC64474 35
tropical clawed frog
(Silurana tropicalis)
Amphibia cmpk1 35
  • 74.75 (n)
  • 82.83 (a)
zebrafish
(Danio rerio)
Actinopterygii cmpk 35
  • 66.05 (n)
  • 71.3 (a)
cmpk 36
  • 67 (a)
OneToOne
Dr.24327 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003968 35
  • 57.95 (n)
  • 60 (a)
fruit fly
(Drosophila melanogaster)
Insecta Dak1 35
  • 56.14 (n)
  • 61.05 (a)
Dak1 36
  • 46 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea C29F7.3 36
  • 54 (a)
OneToMany
F40F8.1 35
  • 57.92 (n)
  • 59.56 (a)
F40F8.1 36
  • 57 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACR170C 35
  • 50.84 (n)
  • 50.28 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes URA6 35
  • 56.05 (n)
  • 51.96 (a)
URA6 36
  • 46 (a)
OneToMany
URA6 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E08053g 35
  • 54.76 (n)
  • 50.55 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons PYR6 35
  • 55.86 (n)
  • 54.59 (a)
rice
(Oryza sativa)
Liliopsida Os.10034 35
Os07g0624700 35
  • 56.54 (n)
  • 54.7 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU02812 35
  • 52.12 (n)
  • 50.83 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPCC1795.05c 35
  • 52.85 (n)
  • 49.17 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4162 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 62 (a)
OneToOne
Species with no ortholog for CMPK1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CMPK1 Gene

ENSEMBL:
Gene Tree for CMPK1 (if available)
TreeFam:
Gene Tree for CMPK1 (if available)

Paralogs for CMPK1 Gene

Paralogs for CMPK1 Gene

Selected SIMAP similar genes for CMPK1 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for CMPK1 Gene

genes like me logo Genes that share paralogs with CMPK1: view

Variants for CMPK1 Gene

Sequence variations from dbSNP and Humsavar for CMPK1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs6795 -- 47,378,792(+) TATCA(A/G)TTATT utr-variant-3-prime, nc-transcript-variant
rs10198 -- 47,377,681(-) AATAA(A/T)ATACA utr-variant-3-prime, nc-transcript-variant
rs1044457 -- 47,377,105(+) ATACC(C/T)GCTTC utr-variant-3-prime, nc-transcript-variant
rs2245850 -- 47,357,478(-) agaaT(C/G)CATTA intron-variant
rs2246707 -- 47,364,967(-) catgc(A/G)caaca intron-variant

Relevant External Links for CMPK1 Gene

HapMap Linkage Disequilibrium report
CMPK1
Human Gene Mutation Database (HGMD)
CMPK1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CMPK1 Gene

Disorders for CMPK1 Gene

(4) Novoseek inferred disease relationships for CMPK1 Gene

Disease -log(P) Hits PubMed IDs
leukemia 20 1
pancreatic cancer 19.9 4
tumors 0 5
cancer 0 3
genes like me logo Genes that share disorders with CMPK1: view

No data available for UniProtKB/Swiss-Prot for CMPK1 Gene

Publications for CMPK1 Gene

  1. Phosphorylation of deoxycytidine analog monophosphates by UMP-CMP kinase: molecular characterization of the human enzyme. (PMID: 10462544) Van Rompay A.R. … Karlsson A. (Mol. Pharmacol. 1999) 2 3 4 23
  2. Characterization of human UMP-CMP kinase enzymatic activity and 5' untranslated region. (PMID: 11681623) Pearman A.T. … Stafforini D.M. (Life Sci. 2001) 3 4 23
  3. Characterization of human UMP/CMP kinase and its phosphorylation of D- and L-form deoxycytidine analogue monophosphates. (PMID: 11912132) Liou J.-Y. … Cheng Y.-C. (Cancer Res. 2002) 3 4 23
  4. Substrate-induced conformational changes in human UMP/CMP kinase. (PMID: 15163660) Segura-Pena D. … Lavie A. (J. Biol. Chem. 2004) 3 4 23
  5. Phosphorylation of Cytidine, Deoxycytidine, and Their Analog Monophosphates by Human UMP/CMP Kinase Is Differentially Regulated by ATP and Magnesium. (PMID: 15550676) Hsu C.H. … Cheng Y.C. (Mol. Pharmacol. 2005) 3 23 25

Products for CMPK1 Gene

  • Addgene plasmids for CMPK1

Sources for CMPK1 Gene

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