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CMKLR1 Gene

protein-coding   GIFtS: 59
GCID: GC12M108681

Chemokine-Like Receptor 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Chemokine-Like Receptor 11 2     CHEMERINR2
Chemerin Receptor1 2     ChemR232
Resolvin E1 Receptor1 2     RVER12
DEZ2 3     Chemokine Receptor-Like 12
G-Protein Coupled Receptor ChemR232 3     Orphan G-Protein Coupled Receptor, Dez2
G-Protein Coupled Receptor DEZ2 3     CHEMR233

External Ids:    HGNC: 21211   Entrez Gene: 12402   Ensembl: ENSG000001746007   OMIM: 6023515   UniProtKB: Q997883   

Export aliases for CMKLR1 gene to outside databases

Previous GC identifers: GC12M107791 GC12M108566 GC12M107187 GC12M105746


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CMKLR1 Gene:
CMKLR1 (chemokine-like receptor 1) is a protein-coding gene. Diseases associated with CMKLR1 include lymphedema, and lupus nephritis. GO annotations related to this gene include G-protein coupled receptor activity and chemokine receptor activity. An important paralog of this gene is LTB4R.

UniProtKB/Swiss-Prot: CML1_HUMAN, Q99788
Function: Receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid derived
molecule resolvin E1. Interaction with RARRES2 induces activation of intracellular signaling molecules, such as
SKY, MAPK1/3 (ERK1/2), MAPK14/P38MAPK and PI3K leading to multifunctional effects, like, reduction of immune
responses, enhancing of adipogenesis and angionesis. Resolvin E1 down-regulates cytokine production in
macrophages by reducing the activation of MAPK1/3 (ERK1/2) and NF-kappa-B. Positively regulates adipogenesis and
adipocyte metabolism. Acts as a coreceptor for several SIV strains (SIVMAC316, SIVMAC239, SIVMACL7E-FR and
SIVSM62A), as well as a primary HIV-1 strain (92UG024-2)

Gene Wiki entry for CMKLR1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000012.12  NC_018923.2  NT_029419.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the CMKLR1 gene promoter:
         AML1a   SREBP-1b   NF-AT   AREB6   NF-AT4   NF-AT2   SREBP-1a   NF-AT3   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCMKLR1 promoter sequence
   Search Chromatin IP Primers for CMKLR1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CMKLR1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.1   Ensembl cytogenetic band:  12q23.3   HGNC cytogenetic band: 12q23.3

CMKLR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CMKLR1 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M108681:  view genomic region     (about GC identifiers)

Start:
108,681,821 bp from pter      End:
108,733,118 bp from pter
Size:
51,298 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CML1_HUMAN, Q99788 (See protein sequence)
Recommended Name: Chemokine-like receptor 1  
Size: 373 amino acids; 42322 Da
Developmental stage: Expressed during bone development
Secondary accessions: A8K6Y5 O75748 Q3KP37 Q5U0H0 Q99789
Alternative splicing: 2 isoforms:  Q99788-1   Q99788-2   (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for CMKLR1: NX_Q99788

Explore proteomics data for CMKLR1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn9, Asn192
  • Modification sites at PhosphoSitePlus

  • See CMKLR1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001135815.1  NP_001135816.1  NP_001135817.1  NP_004063.1  

    ENSEMBL proteins: 
     ENSP00000311733   ENSP00000447579   ENSP00000449716   ENSP00000448925   ENSP00000448362  
     ENSP00000401293   ENSP00000380803  

    CMKLR1 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for CMKLR1
    OriGene Custom MassSpec
    OriGene Custom Protein Services for CMKLR1
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    Novus Biologicals CMKLR1 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CMKLR1

    CMKLR1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of CMKLR1
    R&D Systems Antibodies for CMKLR1 (ChemR23)
    OriGene Antibodies for CMKLR1
    OriGene Custom Antibody Services for CMKLR1
    Novus Biologicals CMKLR1 Antibodies
    Abcam antibodies for CMKLR1
    Cloud-Clone Corp. Antibodies for CMKLR1
    ThermoFisher Antibodies for CMKLR1
    LSBio Antibodies in human, mouse, rat for CMKLR1

    CMKLR1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript CMKLR1-overexpressing Cell Line for Assay
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    Cloud-Clone Corp. ELISAs for CMKLR1
    Cloud-Clone Corp. CLIAs for CMKLR1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RVNR: GPCR / Class A : Resolvin receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: chemerin receptor
    Resolvin receptors
    Chemerin receptor

    4 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR002258 DEZorph_rcpt
     IPR000355 Chemokine_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry Q99788

    ProtoNet protein and cluster: Q99788

    1 Blocks protein domain: IPB002258 DEZ orphan receptor signature

    UniProtKB/Swiss-Prot: CML1_HUMAN, Q99788
    Similarity: Belongs to the G-protein coupled receptor 1 family


    CMKLR1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CML1_HUMAN, Q99788
    Function: Receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid derived
    molecule resolvin E1. Interaction with RARRES2 induces activation of intracellular signaling molecules, such as
    SKY, MAPK1/3 (ERK1/2), MAPK14/P38MAPK and PI3K leading to multifunctional effects, like, reduction of immune
    responses, enhancing of adipogenesis and angionesis. Resolvin E1 down-regulates cytokine production in
    macrophages by reducing the activation of MAPK1/3 (ERK1/2) and NF-kappa-B. Positively regulates adipogenesis and
    adipocyte metabolism. Acts as a coreceptor for several SIV strains (SIVMAC316, SIVMAC239, SIVMACL7E-FR and
    SIVSM62A), as well as a primary HIV-1 strain (92UG024-2)
    Induction: Up-regulated by inflammatory cytokines TNF-alpha and IFN-gamma in monocytes. Up-regulated by TNF-alpha,
    IL-1-beta and IL-6 in endothelial cells

         Genatlas biochemistry entry for CMKLR1:
    chemokine (C-C) like receptor 1

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity TAS9144535
    GO:0004930G-protein coupled receptor activity NAS9603476
    GO:0004950chemokine receptor activity IEA--
    GO:0005515protein binding IPI14530373
         
    CMKLR1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CMKLR1:
     Decreased nuclei size in G2M 

         4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Cmklr1):
     cellular  hematopoietic system  immune system  respiratory system 

    CMKLR1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Cmklr1tm1Dgen for CMKLR1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CMKLR1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CMKLR1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CMKLR1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CMKLR1

    miRNA
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    Block miRNA regulation of human, mouse, rat CMKLR1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CMKLR1 (see all 15):
    hsa-miR-1206 hsa-miR-16-2* hsa-miR-4312 hsa-miR-589* hsa-miR-3138 hsa-miR-544 hsa-miR-149 hsa-miR-3681
    SwitchGear 3'UTR luciferase reporter plasmidCMKLR1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CMKLR1
    Predesigned siRNA for gene silencing in human, mouse, rat CMKLR1

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 4): CMKLR1 (NM_001142343)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CMKLR1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CMKLR1

    Cell Line
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    GenScript CMKLR1-overexpressing Cell Line for Assay
    Browse ESI BIO Cell Lines and PureStem Progenitors for CMKLR1 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CMKLR1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CML1_HUMAN, Q99788: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IDA14530373
    GO:0005887integral component of plasma membrane TAS9425281
    GO:0016021integral component of membrane NAS9603476

    CMKLR1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CMKLR1 About    
    See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    GPCRs, Class A Rhodopsin-like0.43


    1 BioSystems Pathway for CMKLR1
        GPCRs, Class A Rhodopsin-like


        Pathway & Disease-focused RT2 Profiler PCR Arrays including CMKLR1: 
              G Protein Coupled Receptors 384HT in human mouse rat
              Antigen Presenting Cells in human mouse rat
              Chemokines & Receptors in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for CMKLR1

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for CMKLR1 (Q997883 ENSP000003117334) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TPST1O605073, ENSP000003024134I2D: score=1 STRING: ENSP00000302413
    TPST2O607043, ENSP000003398134I2D: score=1 STRING: ENSP00000339813
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001501skeletal system development TAS9144535
    GO:0006935chemotaxis IDA14530373
    GO:0006955immune response TAS9425281
    GO:0007186G-protein coupled receptor signaling pathway NAS9603476
    GO:0010759positive regulation of macrophage chemotaxis IMP19443732

    CMKLR1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CMKLR1 (CML1)

    4 IUPHAR Ligands for CMKLR1 (chemerin receptor)    About this table
    LigandTypeActionAffinityPubmed IDs
    chemerin
    AgonistFull agonist8.3118165312
    chemerin C-terminal peptide
    AgonistFull agonist7.62 - 8.1514701797 18165312
    [3H]resolvin E1
    AgonistAgonist7.9515753205 17339491
    resolvin E1
    AgonistFull agonist7.9515753205 17339491 20887750



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CMKLR1 gene (4 alternative transcripts): 
    NM_001142343.1  NM_001142344.1  NM_001142345.1  NM_004072.2  

    Unigene Cluster for CMKLR1:

    Chemokine-like receptor 1
    Hs.197143  [show with all ESTs]
    Unigene Representative Sequence: NM_001142343
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000312143 ENST00000552995 ENST00000550402 ENST00000550573 ENST00000549466
    ENST00000412676(uc009zuw.3) ENST00000397688(uc001tmw.3 uc001tmv.3 uc009zuv.3)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CMKLR1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CMKLR1 (see all 15):
    hsa-miR-1206 hsa-miR-16-2* hsa-miR-4312 hsa-miR-589* hsa-miR-3138 hsa-miR-544 hsa-miR-149 hsa-miR-3681
    SwitchGear 3'UTR luciferase reporter plasmidCMKLR1 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for CMKLR1
    Predesigned siRNA for gene silencing in human, mouse, rat CMKLR1
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): CMKLR1 (NM_001142343)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CMKLR1
    Primer
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    OriGene qPCR primer pairs and template standards for CMKLR1
    OriGene qSTAR qPCR primer pairs in human, mouse for CMKLR1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CMKLR1
      QuantiTect SYBR Green Assays in human, mouse, rat CMKLR1
      QuantiFast Probe-based Assays in human, mouse, rat CMKLR1

    Additional mRNA sequence: 

    AB112777.1 AK126405.1 AK291800.1 AY497547.1 BC106927.2 BC106928.1 BT019556.1 BT019557.1 
    U79526.1 U79527.1 

    6 DOTS entries:

    DT.112436  DT.91696062  DT.91751216  DT.456392  DT.121200983  DT.75101396 

    8 AceView cDNA sequences:

    AY497547 NM_004072 U79526 U79527 BF889189 CD709798 BE939122 AW771926 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CMKLR1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGCAGCTCA
    CMKLR1 Expression
    About this image


    CMKLR1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 20 entries
             Mononuclear Myocytes Cervical Primary Hypaxial Myotome
     
     Somite (Muscoskeletal System)    fully expand to see all 16 entries
             Mononuclear Myocytes Cervical Primary Hypaxial Myotome
     
     Limb (Muscoskeletal System)    fully expand to see all 4 entries
             Mononuclear Myocytes Hindlimb Dorsal Muscle
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Natural Killer Cells Peripheral Blood
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
    CMKLR1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CMKLR1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.197143

    UniProtKB/Swiss-Prot: CML1_HUMAN, Q99788
    Tissue specificity: Prominently expressed in developing osseous and cartilaginous tissue. Also found in adult
    parathyroid glands. Expressed in cardiovascular system, brain, kidney, gastrointestinal tissues and myeloid
    tissues. Expressed in a broad array of tissues associated with hematopoietic and immune function including,
    spleen, thymus, appendix, lymph node, bone marrow and fetal liver. Among leukocyte populations abundant
    expression in monocyte-derived macrophage and immature dendritic cells (DCs). High expression in blood monocytes
    and low levels in polymorphonuclear cells and T-cells. Expressed on endothelial cells. Highly expressed in
    differentiating adipocytes

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CMKLR1: 
              G Protein Coupled Receptors 384HT in human mouse rat
              Antigen Presenting Cells in human mouse rat
              Chemokines & Receptors in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CMKLR1
    OriGene qSTAR qPCR primer pairs in human, mouse for CMKLR1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CMKLR1
    QuantiTect SYBR Green Assays in human, mouse, rat CMKLR1
    QuantiFast Probe-based Assays in human, mouse, rat CMKLR1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CMKLR1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CMKLR1 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cmklr11 , 5 chemokine-like receptor 11, 5 82.57(n)1
    80.32(a)1
      5 (55.55 cM)5
    147471  NM_008153.31  NP_032179.11 
     1136123545 
    chicken
    (Gallus gallus)
    Aves LOC4255071 chemokine-like receptor 1 66.38(n)
    61.27(a)
      425507  XM_004945610.1  XP_004945667.1 
    lizard
    (Anolis carolinensis)
    Reptilia CMKLR16
    chemokine-like receptor 1
    56(a)
    1 ↔ 1
    GL343282.1(469263-470327)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia cmklr11 chemokine-like receptor 1 59.06(n)
    53.18(a)
      100216025  NM_001142015.1  NP_001135487.1 
    zebrafish
    (Danio rerio)
    Actinopterygii cmklr16
    CMKLR1 (3 of 3)6
    (see all 3)
    chemokine-like receptor 1
    (see all 3)
    39(a)
    36(a)
    (see all 3)
    1 ↔ many
    1 ↔ many
    (see all 3)
    5(22353901-22374123) ENSDARG00000090890
    5(22382986-22383865) ENSDARG00000093228


    ENSEMBL Gene Tree for CMKLR1 (if available)
    TreeFam Gene Tree for CMKLR1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CMKLR1 gene
    LTB4R2  GPR332  LTB4R22  FPR32  FPR12  C5AR12  GPR322  GPR1522  
    FPR22  C5AR22  C3AR12  PTGDR22  GPR12  ENSG000002726582  
    Selected SIMAP similar genes for CMKLR1 using alignment to 4 protein entries:     CML1_HUMAN (see all proteins) (see all similar genes):
    gpcr    C3AR1    CCR5    FPR2    XCR1    CCR2
    FFAR3    GPR34    GALR1    MRGPRX1    PPYR1    RXFP3
    GPR132    CXCR2    FPR1    GPR1    F2RL2    P2RY2

    CMKLR1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CMKLR1 (see all 1155)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs601822821,2
    F--108681367(+) TTGGAG/ATGAAT 4 -- ds50011Minor allele frequency- A:0.02WA 118
    rs1898339961,2
    --108681542(+) TTTACC/TATATT 4 -- ds50010--------
    rs353794211,2
    C,F--108681724(+) CTGGCC/TGCCTC 4 -- ds50015Minor allele frequency- T:0.17NA WA 244
    rs1822007571,2
    --108681903(+) TCACAA/GTAGAA 4 -- ut310--------
    rs748323441,2
    C,F--108682054(+) CAGGAG/ATTGAG 4 -- ut312Minor allele frequency- A:0.04NA 122
    rs1488988971,2
    --108682117(+) CTCAGG/TGGAAG 4 -- ut310--------
    rs1436247221,2
    --108682282(+) CCAATA/CCCCTC 4 -- ut310--------
    rs1140927861,2
    C,F--108682301(+) AGTGCC/TCAGTT 4 -- ut311Minor allele frequency- T:0.03WA 118
    rs731995861,2
    C,F--108682380(+) TGCAGG/TGCTCT 4 -- ut311Minor allele frequency- T:0.03NA 120
    rs1480215411,2
    C--108682425(+) CATCCC/TGGTGC 4 -- ut310--------

    HapMap Linkage Disequilibrium report for CMKLR1 (108681821 - 108733118 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for CMKLR1: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CMKLR1
    DNA2.0 Custom Variant and Variant Library Synthesis for CMKLR1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602351    OMIM disorders: --

    18 diseases for CMKLR1:    
    About MalaCards
    lymphedema    lupus nephritis    nephritis    peritonitis
    insulin resistance    obesity    bipolar disorder    hiv-1
    hepatitis b    rheumatoid arthritis    arthritis    endotheliitis
    cervicitis    lung cancer    hepatitis    schizophrenia
    prostate cancer    prostatitis


    CMKLR1 for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for CMKLR1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inflammation 26.1 1 17339491 (1)
    immunodeficiency 4.03 1 9603476 (1)

    Genetic Association Database (GAD): CMKLR1
    Human Genome Epidemiology (HuGE) Navigator: CMKLR1 (3 documents)

    Export disorders for CMKLR1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CMKLR1 gene, integrated from 10 sources (see all 53):
    (articles sorted by number of sources associating them with CMKLR1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. ChemR23, a putative chemoattractant receptor, is expressed in monocyte-derived dendritic cells and macrophages and is a coreceptor for SIV and some primary HIV-1 strains. (PubMed id 9603476)1, 2, 9 Samson M....Parmentier M. (Eur. J. Immunol. 1998)
    2. Identification of chemerin receptor (ChemR23) in human endothelial cells: chemerin-induced endothelial angiogenesis. (PubMed id 20044979)1, 2, 9 Kaur J.... Randeva H.S. (Biochem. Biophys. Res. Commun. 2010)
    3. Molecular cloning of a novel receptor (CMKLR1) with homology to the chemotactic factor receptors. (PubMed id 8976386)1, 2, 9 Gantz I.... Yamada T. (Cytogenet. Cell Genet. 1996)
    4. Genome-wide association study of survival in non-small cell lung cancer patients receiving platinum-based chemotherapy. (PubMed id 21483023)1, 4 Wu X....Yang P. (J. Natl. Cancer Inst. 2011)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    6. Genome-wide association study to identify single nucleotide polymorphisms (SNPs) associated with the development of erectile dysfunction in African-American men after radiotherapy for prostate cancer. (PubMed id 20932654)1, 4 Kerns S.L....Rosenstein B.S. (Int. J. Radiat. Oncol. Biol. Phys. 2010)
    7. Candidate gene analysis in primary lymphedema. (PubMed id 18564921)1, 4 Ferrell R.E....Finegold D.N. (Lymphat Res Biol 2008)
    8. Stereochemical assignment, antiinflammatory properties, and receptor for the omega-3 lipid mediator resolvin E1. (PubMed id 15753205)1, 2 Arita M.... Serhan C.N. (J. Exp. Med. 2005)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    10. An unappreciated role for RNA surveillance. (PubMed id 14759258)1, 2 Hillman R.T.... Brenner S.E. (Genome Biol. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1240 HGNC: 2121 AceView: CMKLR1 Ensembl:ENSG00000174600 euGenes: HUgn1240
    ECgene: CMKLR1 H-InvDB: CMKLR1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CMKLR1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CMKLR1 gene:
    Search GeneIP for patents involving CMKLR1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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