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Aliases for CMKLR1 Gene

Aliases for CMKLR1 Gene

  • Chemerin Chemokine-Like Receptor 1 2 3 5
  • G-Protein Coupled Receptor ChemR23 3 4
  • G-Protein Coupled Receptor DEZ 3 4
  • Resolvin E1 Receptor 2 3
  • Chemerin Receptor 2 3
  • ChemR23 3 4
  • DEZ 3 4
  • Orphan G-Protein Coupled Receptor, Dez 3
  • Chemokine Receptor-Like 1 3
  • Chemokine-Like Receptor 1 2
  • CHEMERINR 3
  • RVER1 3

External Ids for CMKLR1 Gene

Previous GeneCards Identifiers for CMKLR1 Gene

  • GC12M107791
  • GC12M108566
  • GC12M107187
  • GC12M108681
  • GC12M105746

Summaries for CMKLR1 Gene

GeneCards Summary for CMKLR1 Gene

CMKLR1 (Chemerin Chemokine-Like Receptor 1) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors. GO annotations related to this gene include G-protein coupled receptor activity and chemokine receptor activity. An important paralog of this gene is FPR2.

UniProtKB/Swiss-Prot for CMKLR1 Gene

  • Receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with RARRES2 induces activation of intracellular signaling molecules, such as SKY, MAPK1/3 (ERK1/2), MAPK14/P38MAPK and PI3K leading to multifunctional effects, like, reduction of immune responses, enhancing of adipogenesis and angionesis. Resolvin E1 down-regulates cytokine production in macrophages by reducing the activation of MAPK1/3 (ERK1/2) and NF-kappa-B. Positively regulates adipogenesis and adipocyte metabolism. Acts as a coreceptor for several SIV strains (SIVMAC316, SIVMAC239, SIVMACL7E-FR and SIVSM62A), as well as a primary HIV-1 strain (92UG024-2).

Gene Wiki entry for CMKLR1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CMKLR1 Gene

Genomics for CMKLR1 Gene

Regulatory Elements for CMKLR1 Gene

Enhancers for CMKLR1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CMKLR1 on UCSC Golden Path with GeneCards custom track

Promoters for CMKLR1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CMKLR1 on UCSC Golden Path with GeneCards custom track

Genomic Location for CMKLR1 Gene

Chromosome:
12
Start:
108,288,044 bp from pter
End:
108,339,341 bp from pter
Size:
51,298 bases
Orientation:
Minus strand

Genomic View for CMKLR1 Gene

Genes around CMKLR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CMKLR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CMKLR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CMKLR1 Gene

Proteins for CMKLR1 Gene

  • Protein details for CMKLR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99788-CML1_HUMAN
    Recommended name:
    Chemokine-like receptor 1
    Protein Accession:
    Q99788
    Secondary Accessions:
    • A8K6Y5
    • O75748
    • Q3KP37
    • Q5U0H0
    • Q99789

    Protein attributes for CMKLR1 Gene

    Size:
    373 amino acids
    Molecular mass:
    42322 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CMKLR1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CMKLR1 Gene

Proteomics data for CMKLR1 Gene at MOPED

Post-translational modifications for CMKLR1 Gene

  • Glycosylation at Asn 9 and Asn 192
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for CMKLR1 Gene

Domains & Families for CMKLR1 Gene

Gene Families for CMKLR1 Gene

Protein Domains for CMKLR1 Gene

Suggested Antigen Peptide Sequences for CMKLR1 Gene

Graphical View of Domain Structure for InterPro Entry

Q99788

UniProtKB/Swiss-Prot:

CML1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with CMKLR1: view

Function for CMKLR1 Gene

Molecular function for CMKLR1 Gene

GENATLAS Biochemistry:
chemokine (C-C) like receptor 1
UniProtKB/Swiss-Prot Function:
Receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with RARRES2 induces activation of intracellular signaling molecules, such as SKY, MAPK1/3 (ERK1/2), MAPK14/P38MAPK and PI3K leading to multifunctional effects, like, reduction of immune responses, enhancing of adipogenesis and angionesis. Resolvin E1 down-regulates cytokine production in macrophages by reducing the activation of MAPK1/3 (ERK1/2) and NF-kappa-B. Positively regulates adipogenesis and adipocyte metabolism. Acts as a coreceptor for several SIV strains (SIVMAC316, SIVMAC239, SIVMACL7E-FR and SIVSM62A), as well as a primary HIV-1 strain (92UG024-2).
UniProtKB/Swiss-Prot Induction:
Up-regulated by inflammatory cytokines TNF-alpha and IFN-gamma in monocytes. Up-regulated by TNF-alpha, IL-1-beta and IL-6 in endothelial cells.
genes like me logo Genes that share phenotypes with CMKLR1: view

Animal Models for CMKLR1 Gene

MGI Knock Outs for CMKLR1:

Animal Model Products

  • Taconic Biosciences Mouse Models for CMKLR1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CMKLR1 Gene

Localization for CMKLR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CMKLR1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CMKLR1 Gene COMPARTMENTS Subcellular localization image for CMKLR1 gene
Compartment Confidence
plasma membrane 5
extracellular 1

No data available for Gene Ontology (GO) - Cellular Components for CMKLR1 Gene

Pathways & Interactions for CMKLR1 Gene

SuperPathways for CMKLR1 Gene

genes like me logo Genes that share pathways with CMKLR1: view

Pathways by source for CMKLR1 Gene

1 BioSystems pathway for CMKLR1 Gene

Interacting Proteins for CMKLR1 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000311733%0d%0a9606.ENSP00000302413%0d%0a9606.ENSP00000339813%0d%0a
Selected Interacting proteins: ENSP00000311733 Q99788-CML1_HUMAN for CMKLR1 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for CMKLR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IEA,NAS 9603476
GO:0010759 positive regulation of macrophage chemotaxis IMP 19443732
GO:0032088 negative regulation of NF-kappaB transcription factor activity IDA 15753205
GO:0032695 negative regulation of interleukin-12 production ISS --
GO:0070098 chemokine-mediated signaling pathway TAS 9425281
genes like me logo Genes that share ontologies with CMKLR1: view

No data available for SIGNOR curated interactions for CMKLR1 Gene

Drugs & Compounds for CMKLR1 Gene

(5) Drugs for CMKLR1 Gene - From: DGIdb and IUPHAR

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
[<sup>3</sup>H]resolvin E1 Pharma Agonist 0
chemerin Pharma Full agonist, Agonist 0
chemerin C-terminal peptide Pharma Agonist 0
resolvin E1 Pharma Full agonist, Agonist 0
CCX832 Pharma 0
genes like me logo Genes that share compounds with CMKLR1: view

Transcripts for CMKLR1 Gene

mRNA/cDNA for CMKLR1 Gene

(4) REFSEQ mRNAs :
(10) Additional mRNA sequences :
(8) Selected AceView cDNA sequences:
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CMKLR1 Gene

Chemokine-like receptor 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CMKLR1 Gene

No ASD Table

Relevant External Links for CMKLR1 Gene

GeneLoc Exon Structure for
CMKLR1
ECgene alternative splicing isoforms for
CMKLR1

Expression for CMKLR1 Gene

mRNA expression in normal human tissues for CMKLR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CMKLR1 Gene

This gene is overexpressed in Spleen (x5.8), Artery - Aorta (x5.2), and Artery - Coronary (x4.4).

Protein differential expression in normal tissues from HIPED for CMKLR1 Gene

This gene is overexpressed in NK cells (42.0) and Placenta (27.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CMKLR1 Gene



SOURCE GeneReport for Unigene cluster for CMKLR1 Gene Hs.197143

mRNA Expression by UniProt/SwissProt for CMKLR1 Gene

Q99788-CML1_HUMAN
Tissue specificity: Prominently expressed in developing osseous and cartilaginous tissue. Also found in adult parathyroid glands. Expressed in cardiovascular system, brain, kidney, gastrointestinal tissues and myeloid tissues. Expressed in a broad array of tissues associated with hematopoietic and immune function including, spleen, thymus, appendix, lymph node, bone marrow and fetal liver. Among leukocyte populations abundant expression in monocyte-derived macrophage and immature dendritic cells (DCs). High expression in blood monocytes and low levels in polymorphonuclear cells and T-cells. Expressed on endothelial cells. Highly expressed in differentiating adipocytes.
genes like me logo Genes that share expression patterns with CMKLR1: view

Protein tissue co-expression partners for CMKLR1 Gene

Primer Products

Orthologs for CMKLR1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CMKLR1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CMKLR1 35
  • 85.82 (n)
  • 83.43 (a)
CMLKR1 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CMKLR1 35
  • 87.4 (n)
  • 86.3 (a)
CMKLR1 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cmklr1 35
  • 82.57 (n)
  • 80.32 (a)
Cmklr1 16
Cmklr1 36
  • 80 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cmklr1 35
  • 82.66 (n)
  • 81.94 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia CMKLR1 36
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC425507 35
  • 66.38 (n)
  • 61.27 (a)
lizard
(Anolis carolinensis)
Reptilia CMKLR1 36
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cmklr1 35
  • 59.06 (n)
  • 53.18 (a)
zebrafish
(Danio rerio)
Actinopterygii cmklr1 36
  • 39 (a)
OneToMany
CMKLR1 (2 of 3) 36
  • 36 (a)
OneToMany
CMKLR1 (3 of 3) 36
  • 36 (a)
OneToMany
Species with no ortholog for CMKLR1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CMKLR1 Gene

ENSEMBL:
Gene Tree for CMKLR1 (if available)
TreeFam:
Gene Tree for CMKLR1 (if available)

Paralogs for CMKLR1 Gene

Paralogs for CMKLR1 Gene

genes like me logo Genes that share paralogs with CMKLR1: view

Variants for CMKLR1 Gene

Sequence variations from dbSNP and Humsavar for CMKLR1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs2059596 -- 108,289,411(+) CTAAG(A/T)CAGAA utr-variant-3-prime
rs7133212 -- 108,326,290(+) AAAGC(C/T)TCCCC intron-variant
rs1946 -- 108,289,601(+) CCAAG(G/T)CGCTG utr-variant-3-prime
rs7296628 -- 108,328,248(+) TGGAA(C/T)GAAAC intron-variant
rs7296645 -- 108,328,294(+) AGCCT(C/T)TCATG intron-variant

Variation tolerance for CMKLR1 Gene

Residual Variation Intolerance Score: 63.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.22; 39.96% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for CMKLR1 Gene

Disorders for CMKLR1 Gene

Relevant External Links for CMKLR1

Genetic Association Database (GAD)
CMKLR1
Human Genome Epidemiology (HuGE) Navigator
CMKLR1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CMKLR1

No disorders were found for CMKLR1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CMKLR1 Gene

Publications for CMKLR1 Gene

  1. ChemR23, a putative chemoattractant receptor, is expressed in monocyte-derived dendritic cells and macrophages and is a coreceptor for SIV and some primary HIV-1 strains. (PMID: 9603476) Samson M. … Parmentier M. (Eur. J. Immunol. 1998) 3 4 23 67
  2. Resolvin E1 receptor activation signals phosphorylation and phagocytosis. (PMID: 19906641) Ohira T. … Serhan C.N. (J. Biol. Chem. 2010) 3 23
  3. Identification of chemerin receptor (ChemR23) in human endothelial cells: chemerin-induced endothelial angiogenesis. (PMID: 20044979) Kaur J. … Randeva H.S. (Biochem. Biophys. Res. Commun. 2010) 3 23
  4. Potential role of chemerin in recruitment of plasmacytoid dendritic cells to diseased skin. (PMID: 19168032) SkrzeczyA8ska-Moncznik J. … Cichy J. (Biochem. Biophys. Res. Commun. 2009) 3 23
  5. Molecular cloning of a novel receptor (CMKLR1) with homology to the chemotactic factor receptors. (PMID: 8976386) Gantz I. … Yamada T. (Cytogenet. Cell Genet. 1996) 3 23

Products for CMKLR1 Gene

Sources for CMKLR1 Gene

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