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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CMKLR1 Gene

protein-coding   GIFtS: 56
GCID: GC12M108681

chemokine-like receptor 1
 Explore 12 diseases affiliated with
CMKLR1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CMKLR1    

Aliases
for CMKLR1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Chemokine-Like Receptor 11 2     ChemR232
RVER11 2     Chemokine Receptor-Like 12
DEZ2 3     Orphan G-Protein Coupled Receptor, Dez2
G-Protein Coupled Receptor ChemR232 3     Resolvin E1 Receptor2
G-Protein Coupled Receptor DEZ2 3     CHEMR233
CHEMERINR2     

External Ids:    HGNC: 21211   Entrez Gene: 12402   Ensembl: ENSG000001746007   OMIM: 6023515   UniProtKB: Q997883   

Export aliases for CMKLR1 gene to outside databases

Previous GC identifers: GC12M107791 GC12M108566 GC12M107187 GC12M105746


Summaries
for CMKLR1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: CML1_HUMAN, Q99788
Function: Receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid derived molecule
resolvin E1. Interaction with RARRES2 induces activation of intracellular signaling molecules, such as SKY, MAPK1/3
(ERK1/2), MAPK14/P38MAPK and PI3K leading to multifunctional effects, like, reduction of immune responses, enhancing
of adipogenesis and angionesis. Resolvin E1 down-regulates cytokine production in macrophages by reducing the
activation of MAPK1/3 (ERK1/2) and NF-kappa-B. Acts as a coreceptor for several SIV strains (SIVMAC316, SIVMAC239,
SIVMACL7E-FR and SIVSM62A), as well as a primary HIV-1 strain (92UG024-2)

Gene Wiki entry for CMKLR1


Genomic Views
for CMKLR1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.1  NT_029419.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CMKLR1 gene promoter:
         AML1a   SREBP-1b   NF-AT   AREB6   NF-AT4   NF-AT2   SREBP-1a   NF-AT3   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CMKLR1 promoter sequence
   Search SABiosciences Chromatin IP Primers for CMKLR1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CMKLR1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.1   Ensembl cytogenetic band:  12q23.3   HGNC cytogenetic band: 12q24.1

CMKLR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CMKLR1 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M108681:  view genomic region     (about GC identifiers)

Start:
 108,681,821 bp from pter      End:
 108,733,118 bp from pter
Size:
 51,298 bases      Orientation:
 minus strand

Proteins
for CMKLR1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CML1_HUMAN, Q99788 (See protein sequence)
Recommended Name: Chemokine-like receptor 1  
Size: 373 amino acids; 42322 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Developmental stage: Expressed during bone development
Secondary accessions: A8K6Y5 O75748 Q3KP37 Q5U0H0 Q99789
Alternative splicing: 2 isoforms:  Q99788-1   Q99788-2   (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for CMKLR1: NX_Q99788

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q99788

    • CMKLR1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (4 alternative transcripts): 
    NP_001135815.1  NP_001135816.1  NP_001135817.1  NP_004063.1  

    ENSEMBL proteins: 
     ENSP00000311733   ENSP00000447579   ENSP00000449716   ENSP00000448925   ENSP00000448362  
     ENSP00000401293   ENSP00000380803  

    Human Recombinant Protein Products: 
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    Enzo Life Sciences proteins for CMKLR1
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    OriGene Protein Over-expression Lysate: CMKLR1
    OriGene Custom Protein Services for CMKLR1 
    GenScript Custom Purified and Recombinant Proteins Services for CMKLR1
    Novus Biologicals CMKLR1 Protein
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for CMKLR1

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IDA14530373
    GO:0005887integral to plasma membrane TAS9425281
    GO:0016021integral to membrane NAS9603476


    CMKLR1 for ontologies           About GeneDecksing



    CMKLR1 Antibody Products: 
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    Search for Antibodies for CMKLR1 at Abcam  
    Uscn Antibodies for CMKLR1
    Search ThermoFisher Antibodies for CMKLR1

    Assay Products for CMKLR1: 
    Browse Kits and Assays available from EMD Millipore
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    Browse OriGene Fluorogenic Cell Assay Kits
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    GenScript CMKLR1-overexpressing Cell Line for Assay
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for CMKLR1

    Protein Domains /
    Families
    for CMKLR1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CMKLR1 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR002258 DEZorph_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry Q99788

    ProtoNet protein and cluster: Q99788

    1 Blocks protein family: IPB002258 DEZ orphan receptor signature

    UniProtKB/Swiss-Prot: CML1_HUMAN, Q99788
    Similarity: Belongs to the G-protein coupled receptor 1 family


    Function
    for CMKLR1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: CML1_HUMAN, Q99788
    Function: Receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid derived molecule
    resolvin E1. Interaction with RARRES2 induces activation of intracellular signaling molecules, such as SKY, MAPK1/3
    (ERK1/2), MAPK14/P38MAPK and PI3K leading to multifunctional effects, like, reduction of immune responses, enhancing
    of adipogenesis and angionesis. Resolvin E1 down-regulates cytokine production in macrophages by reducing the
    activation of MAPK1/3 (ERK1/2) and NF-kappa-B. Acts as a coreceptor for several SIV strains (SIVMAC316, SIVMAC239,
    SIVMACL7E-FR and SIVSM62A), as well as a primary HIV-1 strain (92UG024-2)
    Induction: Up-regulated by inflammatory cytokines TNF-alpha and IFN-gamma in monocytes. Up-regulated by TNF-alpha,
    IL-1-beta and IL-6 in endothelial cells

         Genatlas biochemistry entry for CMKLR1:
    chemokine (C-C) like receptor 1

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CMKLR1
    8/15 QIAGEN miScript miRNA Assays for microRNAs that regulate CMKLR1 (see all 15):
    hsa-miR-1206 hsa-miR-16-2* hsa-miR-4312 hsa-miR-589* hsa-miR-3138 hsa-miR-544 hsa-miR-149 hsa-miR-3681
    SwitchGear 3'UTR luciferase reporter plasmid: CMKLR1 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CMKLR1 (see all 7)
    OriGene shRNA RFP: CMKLR1
    OriGene siRNA: CMKLR1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CMKLR1

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for CMKLR1

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CMKLR1 (see all 6)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CMKLR1 (see all 4)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 4): CMKLR1 (NM_001142343)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CMKLR1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CMKLR1 

    Cell Line
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    Search LifeMap BioReagents cell lines for CMKLR1

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CMKLR1

    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity TAS9144535
    GO:0004930G-protein coupled receptor activity NAS9603476
    GO:0004950chemokine receptor activity TAS9425281
    GO:0005515protein binding IPI14530373


    CMKLR1 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for CMKLR1:
     Decreased nuclei size in G2M 

    Animal Models:
         Mouse knock-out Cmklr1tm1Dgen for CMKLR1
         4 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Cmklr1):
     cellular  hematopoietic system  immune system  respiratory system 

    CMKLR1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for CMKLR1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Class A/1 (Rhodopsin-like receptors)
    		GPCRs, Class A Rhodopsin-like0.41


    1 BioSystems Pathway for CMKLR1 
        GPCRs, Class A Rhodopsin-like


    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CMKLR1

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for CMKLR1 (Q997883 ENSP000003117334) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TPST1O605073, ENSP000003024134I2D: score=1 STRING: ENSP00000302413
    TPST2O607043, ENSP000003398134I2D: score=1 STRING: ENSP00000339813
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001501skeletal system development TAS9144535
    GO:0006935chemotaxis IDA14530373
    GO:0006955immune response TAS9425281
    GO:0007186G-protein coupled receptor signaling pathway NAS9603476
    GO:0010759positive regulation of macrophage chemotaxis IMP19443732


    CMKLR1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for CMKLR1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CMKLR1
    Search CenterWatch for drugs/clinical trials and news about CMKLR1 / CML1 

    Transcripts
    for CMKLR1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CMKLR1 gene (4 alternative transcripts): 
    NM_001142343.1  NM_001142344.1  NM_001142345.1  NM_004072.2  

    Unigene Cluster for CMKLR1:

    Chemokine-like receptor 1
    Hs.197143  [show with all ESTs]
    Unigene Representative Sequence: NM_001142343
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000312143 ENST00000552995 ENST00000550402 ENST00000550573 ENST00000549466
    ENST00000412676(uc009zuw.3) ENST00000397688(uc001tmw.3 uc001tmv.3 uc009zuv.3)


    miRNA
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    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CMKLR1
    8/15 QIAGEN miScript miRNA Assays for microRNAs that regulate CMKLR1 (see all 15):
    hsa-miR-1206 hsa-miR-16-2* hsa-miR-4312 hsa-miR-589* hsa-miR-3138 hsa-miR-544 hsa-miR-149 hsa-miR-3681
    SwitchGear 3'UTR luciferase reporter plasmid: CMKLR1 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CMKLR1 (see all 7)
    OriGene shRNA RFP: CMKLR1
    OriGene siRNA: CMKLR1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CMKLR1
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CMKLR1 (see all 6)
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 4): CMKLR1 (NM_001142343)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CMKLR1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CMKLR1 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CMKLR1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CMKLR1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CMKLR1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CMKLR1

    Additional cDNA sequence: 

    AB112777.1 AK126405.1 AK291800.1 AY497547.1 BC106927.2 BC106928.1 BT019556.1 BT019557.1 
    U79526.1 U79527.1 

    6 DOTS entries:

    DT.112436  DT.91696062  DT.91751216  DT.456392  DT.121200983  DT.75101396 

    8 AceView cDNA sequences:

    AY497547 NM_004072 U79527 BF889189 U79526 CD709798 AW771926 BE939122 

    GeneLoc Exon Structure


    Expression
    for CMKLR1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CMKLR1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GAGCAGCTCA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    CMKLR1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    10/20 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 20) 
    Tissue Anatomical Compartment CellCategory (developmental path)
    LimbForelimb Dorsal MusclesMononuclear MyocytesSkeletal Muscle
    LimbForelimb Ventral MusclesMononuclear MyocytesSkeletal Muscle
    LimbHindlimb Dorsal MuscleMononuclear MyocytesSkeletal Muscle
    LimbHindlimb Ventral MuscleMononuclear MyocytesSkeletal Muscle
    Skeletal MuscleThoracic Epaxial MyotomeMononuclear MyocytesSkeletal Muscle
    SomiteCervical Epaxial MyotomeMononuclear MyocytesSkeletal Muscle
    SomiteCervical Hypaxial MyotomeMononuclear MyocytesSkeletal Muscle
    SomiteCervical Primary Epaxial MyotomeMononuclear MyocytesSkeletal Muscle
    SomiteCervical Primary Hypaxial MyotomeMononuclear MyocytesSkeletal Muscle
    SomiteLumbar Epaxial MyotomeMononuclear MyocytesSkeletal Muscle
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    PureStem™ progenitor EN7 (Embryonic Progenitor Cell)

    See CMKLR1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CMKLR1

    SOURCE GeneReport for Unigene cluster: Hs.197143

    UniProtKB/Swiss-Prot: CML1_HUMAN, Q99788
    Tissue specificity: Prominently expressed in developing osseous and cartilaginous tissue. Also found in adult
    parathyroid glands. Expressed in cardiovascular system, brain, kidney, gastrointestinal tissues and myeloid tissues.
    Expressed in a broad array of tissues associated with hematopoietic and immune function including, spleen, thymus,
    appendix, lymph node, bone marrow and fetal liver. Among leukocyte populations abundant expression in monocyte-derived
    macrophage and immature dendritic cells (DCs). High expression in blood monocytes and low levels in polymorphonuclear
    cells and T-cells. Expressed on endothelial cells

        SABiosciences Expression via Pathway-Focused PCR Arrays including CMKLR1: 
              G Protein Coupled Receptors 384HT in human mouse rat
              Antigen Presenting Cells in human mouse rat
              Chemokines & Receptors in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CMKLR1
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CMKLR1

    Orthologs
    for CMKLR1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for CMKLR1 gene from 3/9 species (see all 9)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves LOC4276651 chemokine-like receptor 1-like 59.04(n)
    50(a)    		   427665  XM_425239.2  XP_425239.2 
    lizard
    (Anolis carolinensis)    		 Reptilia CMKLR16
    --
    (see all 3)    		 --
    		 54(a)
    32(a)
    (see all 3)    		 1 ↔ 1
    possible ortholog
    (see all 3)    		 GL343282.1(469263-470321)
    GL343604.1(277-1212)
    zebrafish
    (Danio rerio)    		 Actinopterygii LOC5681531 chemokine-like receptor 1-like 54.99(n)
    46.15(a)    		   568153  XM_003200188.1  XP_003200236.1 


    ENSEMBL Gene Tree for CMKLR1 (if available)
    TreeFam Gene Tree for CMKLR1 (if available) 

    Paralogs
    for CMKLR1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CMKLR1 gene
    LTB4R2  LTB4R22  FPR32  FPR12  C5AR12  GPR322  GPR1522  FPR22  
    C5AR22  C3AR12  PTGDR22  GPR12  
    18/57 SIMAP similar genes for CMKLR1 using alignment to 4 protein entries:     CML1_HUMAN (see all proteins) (see all similar genes):
    gpcr    C3AR1    CCR5    XCR1    FFAR3    GPR34
    GALR1    MRGPRX1    PPYR1    RXFP3    G2A    GPR132
    CXCR2    GPR1    F2RL2    P2RY2    CX3CR1    BDKRB1

    CMKLR1 for paralogs           About GeneDecksing



    Genomic Variants
    for CMKLR1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/990 NCBI SNPs in CMKLR1 are shown (see all 990)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 12 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs601822821,2
    		F,--108681367(+) TTGGAG/ATGAAT 4 -- ds50011Minor allele frequency- A:0.02WA 118
    rs1898339961,2
    		--108681542(+) TTTACC/TATATT 4 -- ds50010--------
    rs353794211,2
    		C,F,--108681724(+) CTGGCC/TGCCTC 4 -- ds50015Minor allele frequency- T:0.17NA WA 244
    rs1822007571,2
    		--108681903(+) TCACAA/GTAGAA 4 -- ut310--------
    rs748323441,2
    		C,--108682054(+) CAGGAG/ATTGAG 4 -- ut312Minor allele frequency- A:0.04NA 122
    rs1488988971,2
    		--108682117(+) CTCAGG/TGGAAG 4 -- ut310--------
    rs1436247221,2
    		--108682282(+) CCAATA/CCCCTC 4 -- ut310--------
    rs1140927861,2
    		F,--108682301(+) AGTGCC/TCAGTT 4 -- ut311Minor allele frequency- T:0.03WA 118
    rs731995861,2
    		C,F,--108682380(+) TGCAGG/TGCTCT 4 -- ut311Minor allele frequency- T:0.03NA 120
    rs1480215411,2
    		--108682425(+) CATCCC/TGGTGC 4 -- ut310--------

    HapMap Linkage Disequilibrium report for CMKLR1 (108681821 - 108733118 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for CMKLR1: --

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    Disorders / Diseases
    for CMKLR1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CMKLR1 for disorders           About GeneDecksing

    OMIM gene information: 602351    OMIM disorders: --

    12 diseases for CMKLR1:    About MalaCards
    lupus nephritis    insulin resistance    lymphedema    nephritis
    hepatitis b    immunodeficiency    peritonitis    lung cancer
    prostate cancer    hepatitis    obesity    prostatitis

    2 Novoseek disease relationships for CMKLR1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inflammation 26.1 1 17339491 (1)
    immunodeficiency 4.03 1 9603476 (1)

    Human Genome Epidemiology (HuGE) Navigator: CMKLR1 (3 documents)

    Export disorders for CMKLR1 gene to outside databases

    Publications
    for CMKLR1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CMKLR1 gene, integrated from 9 sources (see all 47):
    (articles sorted by number of sources associating them with CMKLR1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. ChemR23, a putative chemoattractant receptor, is expressed in monocyte-derived dendritic cells and macrophages and is a coreceptor for SIV and some primary HIV-1 strains. (PubMed id 9603476)1, 2, 9 Samson M....Parmentier M. (1998)
    2. Identification of chemerin receptor (ChemR23) in huma n endothelial cells: chemerin-induced endothelial angiogenesis. (PubMed id 20044979)1, 2, 9 Kaur J....Randeva H.S. (2010)
    3. Molecular cloning of a novel receptor (CMKLR1) with homology to the chemotactic factor receptors. (PubMed id 8976386)1, 2, 9 Gantz I.... Yamada T. (1996)
    4. Stereochemical assignment, antiinflammatory properties, and receptor for the omega-3 lipid mediator resolvin E1. (PubMed id 15753205)1, 2 Arita M....Serhan C.N. (2005)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. An unappreciated role for RNA surveillance. (PubMed id 14759258)1, 2 Hillman R.T.... Brenner S.E. (2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. Specific recruitment of antigen-presenting cells by chemerin, a novel processed ligand from human inflammatory fluids. (PubMed id 14530373)1, 2 Wittamer V....Communi D. (2003)
    9. A novel G protein-coupled receptor with homology to neuropeptide and chemoattractant receptors expressed during bone development. (PubMed id 9144535)1, 2 Methner A.... Hermans-Borgmeyer I. (1997)
    10. Chemokine-like receptor 1 expression by macrophages in vivo: regulation by TGF-beta and TLR ligands. (PubMed id 16863918)2, 9 Zabel B.A....Butcher E.C. (2006)

    External Searches for CMKLR1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing CMKLR1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1240 HGNC: 2121 AceView: CMKLR1 Ensembl:ENSG00000174600 euGenes: HUgn1240
    ECgene: CMKLR1 H-InvDB: CMKLR1

    Other Databases showing CMKLR1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CMKLR1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CMKLR1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for CMKLR1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CMKLR1 gene:
    Search GeneIP for patents involving CMKLR1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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