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Aliases for CMIP Gene

Aliases for CMIP Gene

  • C-Maf Inducing Protein 2 3 5
  • Tc-Mip 3 4
  • TCMIP 3 4
  • Truncated C-Maf-Inducing Protein 4
  • KIAA1694 4
  • C-Mip 4

External Ids for CMIP Gene

Previous GeneCards Identifiers for CMIP Gene

  • GC16P081258
  • GC16P080036
  • GC16P067234

Summaries for CMIP Gene

Entrez Gene Summary for CMIP Gene

  • This gene encodes a c-Maf inducing protein that plays a role in T-cell signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]

GeneCards Summary for CMIP Gene

CMIP (C-Maf Inducing Protein) is a Protein Coding gene. Diseases associated with CMIP include Speech And Communication Disorders and Specific Language Impairment.

UniProtKB/Swiss-Prot for CMIP Gene

  • Plays a role in T-cell signaling pathway. Isoform 2 may play a role in T-helper 2 (Th2) signaling pathway and seems to represent the first proximal signaling protein that links T-cell receptor-mediated signal to the activation of c-Maf Th2 specific factor.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CMIP Gene

Genomics for CMIP Gene

Regulatory Elements for CMIP Gene

Enhancers for CMIP Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CMIP on UCSC Golden Path with GeneCards custom track

Promoters for CMIP Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CMIP on UCSC Golden Path with GeneCards custom track

Genomic Location for CMIP Gene

81,445,170 bp from pter
81,711,762 bp from pter
266,593 bases
Plus strand

Genomic View for CMIP Gene

Genes around CMIP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CMIP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CMIP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CMIP Gene

Proteins for CMIP Gene

  • Protein details for CMIP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    C-Maf-inducing protein
    Protein Accession:
    Secondary Accessions:
    • Q9C0G9

    Protein attributes for CMIP Gene

    773 amino acids
    Molecular mass:
    86331 Da
    Quaternary structure:
    • Interacts with FLNA.

    Alternative splice isoforms for CMIP Gene


neXtProt entry for CMIP Gene

Proteomics data for CMIP Gene at MOPED

Post-translational modifications for CMIP Gene

  • Ubiquitination at Lys 74 and Lys 79
  • Modification sites at PhosphoSitePlus

Other Protein References for CMIP Gene

No data available for DME Specific Peptides for CMIP Gene

Domains & Families for CMIP Gene

Protein Domains for CMIP Gene

Suggested Antigen Peptide Sequences for CMIP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 PH domain.
  • Contains 4 LRR (leucine-rich) repeats.
  • Contains 1 PH domain.
  • Contains 4 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with CMIP: view

No data available for Gene Families for CMIP Gene

Function for CMIP Gene

Molecular function for CMIP Gene

UniProtKB/Swiss-Prot Function:
Plays a role in T-cell signaling pathway. Isoform 2 may play a role in T-helper 2 (Th2) signaling pathway and seems to represent the first proximal signaling protein that links T-cell receptor-mediated signal to the activation of c-Maf Th2 specific factor.
genes like me logo Genes that share phenotypes with CMIP: view

Animal Models for CMIP Gene

MGI Knock Outs for CMIP:
  • Cmip tm1a(EUCOMM)Wtsi

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CMIP Gene

Localization for CMIP Gene

Subcellular locations from UniProtKB/Swiss-Prot for CMIP Gene

Nucleus. Cytoplasm. Note=Isoform 2 is translocated to the nucleus and is specifically recruited during minimal change nephrotic syndrome (MCNS) (PubMed:12939343) (PubMed:15616553). Detected in nuclear and cytoplasmic compartments during MCNS relapse (PubMed:12939343) (PubMed:15616553). Expressed in cytoplasm only during MCNS remission and absent in normal patients (PubMed:12939343). {ECO:0000269 PubMed:12939343, ECO:0000269 PubMed:15616553}.

Subcellular locations from

Jensen Localization Image for CMIP Gene COMPARTMENTS Subcellular localization image for CMIP gene
Compartment Confidence
nucleus 4
cytosol 2
cytoskeleton 1
mitochondrion 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for CMIP Gene

Pathways & Interactions for CMIP Gene

SuperPathways for CMIP Gene

No Data Available

Gene Ontology (GO) - Biological Process for CMIP Gene


No data available for Pathways by source and SIGNOR curated interactions for CMIP Gene

Drugs & Compounds for CMIP Gene

No Compound Related Data Available

Transcripts for CMIP Gene

Unigene Clusters for CMIP Gene

C-Maf inducing protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CMIP Gene

No ASD Table

Relevant External Links for CMIP Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CMIP Gene

mRNA expression in normal human tissues for CMIP Gene

Protein differential expression in normal tissues from HIPED for CMIP Gene

This gene is overexpressed in Platelet (28.0) and Peripheral blood mononuclear cells (22.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for CMIP Gene

SOURCE GeneReport for Unigene cluster for CMIP Gene Hs.594095

mRNA Expression by UniProt/SwissProt for CMIP Gene

Tissue specificity: Isoform 1 is expressed in peripheral blood mononuclear cells and kidney. Lower expression in brain and liver. Expression is down-regulated in activated cells. Isoform 2 is expressed in lymphocyte precursors, however, expression shuts down during maturation and differentiation in thymus and fetal liver.
genes like me logo Genes that share expression patterns with CMIP: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein tissue co-expression partners for CMIP Gene

Orthologs for CMIP Gene

This gene was present in the common ancestor of chordates.

Orthologs for CMIP Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CMIP 35
  • 94.21 (n)
  • 99.26 (a)
  • 99 (a)
(Canis familiaris)
Mammalia CMIP 35
  • 94.23 (n)
  • 98.96 (a)
  • 99 (a)
(Mus musculus)
Mammalia Cmip 35
  • 91.11 (n)
  • 98.58 (a)
Cmip 16
Cmip 36
  • 96 (a)
(Pan troglodytes)
Mammalia CMIP 35
  • 99.65 (n)
  • 100 (a)
  • 94 (a)
(Rattus norvegicus)
Mammalia Cmip 35
  • 91.23 (n)
  • 98.7 (a)
(Monodelphis domestica)
Mammalia CMIP 36
  • 95 (a)
(Ornithorhynchus anatinus)
Mammalia CMIP 36
  • 93 (a)
(Gallus gallus)
Aves CMIP 35
  • 81.94 (n)
  • 92.84 (a)
  • 95 (a)
(Anolis carolinensis)
Reptilia CMIP 36
  • 94 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cmip 35
  • 79.66 (n)
  • 91.06 (a)
Str.7218 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.7889 35
(Danio rerio)
Actinopterygii cmip 35
  • 78.72 (n)
  • 86.85 (a)
Dr.27534 35
cmip 36
  • 86 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 41 (a)
Species with no ortholog for CMIP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CMIP Gene

Gene Tree for CMIP (if available)
Gene Tree for CMIP (if available)

Paralogs for CMIP Gene

No data available for Paralogs for CMIP Gene

Variants for CMIP Gene

Sequence variations from dbSNP and Humsavar for CMIP Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs3863481 -- 81,683,515(+) ctccc(A/C)agtag intron-variant
rs3863482 -- 81,683,523(+) tagct(A/G)ggatt intron-variant
rs3863488 -- 81,683,546(+) cacca(A/C)gccag intron-variant
rs3863489 -- 81,683,548(+) ccacg(C/T)caggc intron-variant
rs3863490 -- 81,683,550(+) acgcc(A/T)ggcta intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CMIP Gene

Variant ID Type Subtype PubMed ID
esv34108 CNV Loss 18971310
esv23710 CNV Loss 19812545
nsv907010 CNV Loss 21882294
nsv518910 CNV Loss 19592680
nsv522140 CNV Gain 19592680
nsv521875 CNV Loss 19592680
nsv457576 CNV Loss 19166990
esv2714779 CNV Deletion 23290073
esv2714780 CNV Deletion 23290073
nsv526331 CNV Loss 19592680
nsv520382 CNV Loss 19592680
nsv1898 CNV Loss 18451855
nsv524589 CNV Loss 19592680
esv2325065 CNV Deletion 18987734
nsv510427 CNV Loss 20534489
esv2714781 CNV Deletion 23290073
esv3256 CNV Deletion 18987735
nsv907011 CNV Loss 21882294
esv2714782 CNV Deletion 23290073
esv2714783 CNV Deletion 23290073
dgv410e201 CNV Deletion 23290073
esv2714786 CNV Deletion 23290073
esv1774977 CNV Deletion 17803354
dgv411e201 CNV Deletion 23290073
esv2714789 CNV Deletion 23290073
nsv513456 CNV Insertion 21212237

Variation tolerance for CMIP Gene

Residual Variation Intolerance Score: 5.62% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.73; 15.42% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CMIP Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CMIP Gene

Disorders for CMIP Gene

MalaCards: The human disease database

(3) MalaCards diseases for CMIP Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
speech and communication disorders
  • communication disorder
specific language impairment
nephrotic syndrome
  • finnish congenital nephrosis
- elite association - COSMIC cancer census association via MalaCards
Search CMIP in MalaCards View complete list of genes associated with diseases

Relevant External Links for CMIP

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with CMIP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CMIP Gene

Publications for CMIP Gene

  1. Truncation of C-mip (Tc-mip), a new proximal signaling protein, induces c-maf Th2 transcription factor and cytoskeleton reorganization. (PMID: 12939343) Grimbert P. … Sahali D. (J. Exp. Med. 2003) 2 3 4 23 67
  2. CMIP and ATP2C2 modulate phonological short-term memory in language impairment. (PMID: 19646677) Newbury D.F. … Monaco A.P. (Am. J. Hum. Genet. 2009) 3 23
  3. The Filamin-A is a partner of Tc-mip, a new adapter protein involved in c-maf-dependent Th2 signaling pathway. (PMID: 15128042) Grimbert P. … Sahali D. (Mol. Immunol. 2004) 3 23
  4. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11214970) Nagase T. … Ohara O. (DNA Res. 2000) 2 3
  5. Expression patterns of RelA and c-mip are associated with different glomerular diseases following anti-VEGF therapy. (PMID: 24067439) Izzedine H. … Sahali D. (Kidney Int. 2014) 3

Products for CMIP Gene

Sources for CMIP Gene