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Aliases for CMIP Gene

Aliases for CMIP Gene

  • C-Maf Inducing Protein 2 3 5
  • Tc-Mip 3 4
  • TCMIP 3 4
  • Truncated C-Maf-Inducing Protein 4
  • C-Maf-Inducing Protein 3
  • KIAA1694 4
  • C-Mip 4

External Ids for CMIP Gene

Previous GeneCards Identifiers for CMIP Gene

  • GC16P081258
  • GC16P080036
  • GC16P067234

Summaries for CMIP Gene

Entrez Gene Summary for CMIP Gene

  • This gene encodes a c-Maf inducing protein that plays a role in T-cell signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]

GeneCards Summary for CMIP Gene

CMIP (C-Maf Inducing Protein) is a Protein Coding gene. Diseases associated with CMIP include Speech And Communication Disorders and Specific Language Impairment.

UniProtKB/Swiss-Prot for CMIP Gene

  • Plays a role in T-cell signaling pathway. Isoform 2 may play a role in T-helper 2 (Th2) signaling pathway and seems to represent the first proximal signaling protein that links T-cell receptor-mediated signal to the activation of c-Maf Th2 specific factor.

Additional gene information for CMIP Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CMIP Gene

Genomics for CMIP Gene

Regulatory Elements for CMIP Gene

Enhancers for CMIP Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16H081476 2 FANTOM5 Ensembl ENCODE dbSUPER 24.7 +35.4 35356 7.3 HDGF PKNOX1 FOXA2 ARNT ARID4B YY1 ZNF766 ZNF143 ZNF207 SP5 CMIP PLCG2 PPIAP51 ENSG00000279476
GH16H081517 2 FANTOM5 Ensembl ENCODE dbSUPER 23.2 +80.5 80457 17.3 PKNOX1 ATF1 FOXA2 MLX ARID4B SIN3A DMAP1 YY1 TCF12 FOS CMIP PKD1L2 PLCG2 ENSG00000279476 MIR7854
GH16H081467 1.8 FANTOM5 Ensembl ENCODE dbSUPER 23.8 +24.3 24345 3.2 PKNOX1 ATF1 ARNT ZNF766 GATA2 ELK1 ATF7 RUNX3 REST ZNF592 CMIP PLCG2 MPHOSPH6 ENSG00000279021 PPIAP51
GH16H081623 2 FANTOM5 Ensembl ENCODE dbSUPER 18.9 +180.3 180308 4 HDGF PKNOX1 FOXA2 MLX ARNT ARID4B ZNF766 ZNF143 FOS JUNB CMIP GCSH PLCG2 ENSG00000279841 ENSG00000279294
GH16H081557 1.7 FANTOM5 Ensembl ENCODE dbSUPER 19.6 +113.6 113600 2.8 ELF3 FOXA2 ARID4B SIN3A RAD21 RARA ZSCAN5C CREM ZEB2 KAT8 CMIP GAN MIR7854 MIR6504
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CMIP on UCSC Golden Path with GeneCards custom track

Promoters for CMIP Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Locations for CMIP Gene

Genomic Locations for CMIP Gene
266,593 bases
Plus strand

Genomic View for CMIP Gene

Genes around CMIP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CMIP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CMIP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CMIP Gene

Proteins for CMIP Gene

  • Protein details for CMIP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    C-Maf-inducing protein
    Protein Accession:
    Secondary Accessions:
    • Q9C0G9

    Protein attributes for CMIP Gene

    773 amino acids
    Molecular mass:
    86331 Da
    Quaternary structure:
    • Interacts with FLNA.

    Alternative splice isoforms for CMIP Gene


neXtProt entry for CMIP Gene

Post-translational modifications for CMIP Gene

  • Ubiquitination at posLast=7474 and Lys79
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CMIP Gene

Domains & Families for CMIP Gene

Gene Families for CMIP Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CMIP Gene

Suggested Antigen Peptide Sequences for CMIP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CMIP: view

No data available for UniProtKB/Swiss-Prot for CMIP Gene

Function for CMIP Gene

Molecular function for CMIP Gene

UniProtKB/Swiss-Prot Function:
Plays a role in T-cell signaling pathway. Isoform 2 may play a role in T-helper 2 (Th2) signaling pathway and seems to represent the first proximal signaling protein that links T-cell receptor-mediated signal to the activation of c-Maf Th2 specific factor.

Phenotypes From GWAS Catalog for CMIP Gene

Gene Ontology (GO) - Molecular Function for CMIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20018188
genes like me logo Genes that share ontologies with CMIP: view
genes like me logo Genes that share phenotypes with CMIP: view

Animal Models for CMIP Gene

MGI Knock Outs for CMIP:
  • Cmip tm1a(EUCOMM)Wtsi

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CMIP Gene

Localization for CMIP Gene

Subcellular locations from UniProtKB/Swiss-Prot for CMIP Gene

Nucleus. Cytoplasm. Note=Isoform 2 is translocated to the nucleus and is specifically recruited during minimal change nephrotic syndrome (MCNS) (PubMed:12939343) (PubMed:15616553). Detected in nuclear and cytoplasmic compartments during MCNS relapse (PubMed:12939343) (PubMed:15616553). Expressed in cytoplasm only during MCNS remission and absent in normal patients (PubMed:12939343). {ECO:0000269 PubMed:12939343, ECO:0000269 PubMed:15616553}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CMIP gene
Compartment Confidence
nucleus 5
cytosol 5
cytoskeleton 1
mitochondrion 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CMIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with CMIP: view

Pathways & Interactions for CMIP Gene

No Data Available

Gene Ontology (GO) - Biological Process for CMIP Gene


No data available for Pathways by source and SIGNOR curated interactions for CMIP Gene

Drugs & Compounds for CMIP Gene

No Compound Related Data Available

Transcripts for CMIP Gene

Unigene Clusters for CMIP Gene

C-Maf inducing protein:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CMIP Gene

No ASD Table

Relevant External Links for CMIP Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CMIP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CMIP Gene

Protein differential expression in normal tissues from HIPED for CMIP Gene

This gene is overexpressed in Platelet (28.0) and Peripheral blood mononuclear cells (22.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CMIP Gene

NURSA nuclear receptor signaling pathways regulating expression of CMIP Gene:


SOURCE GeneReport for Unigene cluster for CMIP Gene:


mRNA Expression by UniProt/SwissProt for CMIP Gene:

Tissue specificity: Isoform 1 is expressed in peripheral blood mononuclear cells and kidney. Lower expression in brain and liver. Expression is down-regulated in activated cells. Isoform 2 is expressed in lymphocyte precursors, however, expression shuts down during maturation and differentiation in thymus and fetal liver.

Evidence on tissue expression from TISSUES for CMIP Gene

  • Nervous system(4.6)
  • Liver(4.2)
  • Lung(2.8)
  • Kidney(2.2)
genes like me logo Genes that share expression patterns with CMIP: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CMIP Gene

Orthologs for CMIP Gene

This gene was present in the common ancestor of chordates.

Orthologs for CMIP Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CMIP 33 34
  • 99.65 (n)
(Monodelphis domestica)
Mammalia CMIP 34
  • 95 (a)
(Canis familiaris)
Mammalia CMIP 33 34
  • 94.23 (n)
(Bos Taurus)
Mammalia CMIP 33 34
  • 94.21 (n)
(Ornithorhynchus anatinus)
Mammalia CMIP 34
  • 93 (a)
(Rattus norvegicus)
Mammalia Cmip 33
  • 91.23 (n)
(Mus musculus)
Mammalia Cmip 33 16 34
  • 91.11 (n)
(Gallus gallus)
Aves CMIP 33 34
  • 81.94 (n)
(Anolis carolinensis)
Reptilia CMIP 34
  • 94 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cmip 33
  • 79.66 (n)
Str.7218 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.7889 33
(Danio rerio)
Actinopterygii cmip 33 34
  • 78.72 (n)
Dr.27534 33
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 41 (a)
Species where no ortholog for CMIP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CMIP Gene

Gene Tree for CMIP (if available)
Gene Tree for CMIP (if available)

Paralogs for CMIP Gene

No data available for Paralogs for CMIP Gene

Variants for CMIP Gene

Sequence variations from dbSNP and Humsavar for CMIP Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1000006954 -- 81,479,805(+) CCCCC(A/G)GCTCT intron-variant
rs1000022046 -- 81,587,445(+) GGGCC(A/G)GTTTC intron-variant
rs1000030511 -- 81,648,453(+) GGCTG(G/T)GGGAT intron-variant
rs1000036108 -- 81,661,380(+) CCGCT(G/T)CCGGG intron-variant
rs1000037763 -- 81,649,498(+) AGGGC(G/T)GGTTG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CMIP Gene

Variant ID Type Subtype PubMed ID
esv2714786 CNV deletion 23290073
esv2714783 CNV deletion 23290073
esv2714782 CNV deletion 23290073
esv2714781 CNV deletion 23290073
esv2714780 CNV deletion 23290073
esv2714779 CNV deletion 23290073
esv23710 CNV loss 19812545
esv2325065 CNV deletion 18987734
esv1774977 CNV deletion 17803354
dgv5250n54 CNV loss 21841781
dgv374e201 CNV deletion 23290073
dgv373e201 CNV deletion 23290073
dgv1645e59 CNV duplication 20981092
nsv978171 CNV duplication 23825009
nsv952058 CNV deletion 24416366
nsv952057 CNV deletion 24416366
nsv573360 CNV loss 21841781
nsv573359 CNV loss 21841781
nsv526331 CNV loss 19592680
nsv524589 CNV loss 19592680
nsv522140 CNV gain 19592680
nsv521875 CNV loss 19592680
nsv520382 CNV loss 19592680
nsv518910 CNV loss 19592680
nsv513456 CNV insertion 21212237
nsv510427 OTHER sequence alteration 20534489
nsv457576 CNV loss 19166990
nsv1898 CNV deletion 18451855
nsv1138471 CNV deletion 24896259
nsv1136219 CNV deletion 24896259
nsv1134570 CNV deletion 24896259
nsv1132439 CNV duplication 24896259
nsv1126436 CNV deletion 24896259
nsv1118358 CNV deletion 24896259
nsv1118357 CNV deletion 24896259
nsv1076437 CNV duplication 25765185
nsv1071340 CNV deletion 25765185
nsv1070776 CNV deletion 25765185
esv3639339 CNV loss 21293372
esv3639338 CNV loss 21293372
esv3639337 CNV loss 21293372
esv3639335 CNV loss 21293372
esv3639334 CNV loss 21293372
esv3639330 CNV loss 21293372
esv3553753 CNV deletion 23714750
esv3422126 CNV insertion 20981092
esv3419798 CNV duplication 20981092
esv34108 CNV loss 18971310
esv3256 CNV loss 18987735
esv2714789 CNV deletion 23290073

Variation tolerance for CMIP Gene

Residual Variation Intolerance Score: 5.62% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.73; 15.42% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CMIP Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CMIP Gene

Disorders for CMIP Gene

MalaCards: The human disease database

(3) MalaCards diseases for CMIP Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
speech and communication disorders
  • communication disorder
specific language impairment
frasier syndrome
  • fs
- elite association - COSMIC cancer census association via MalaCards
Search CMIP in MalaCards View complete list of genes associated with diseases

Relevant External Links for CMIP

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with CMIP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CMIP Gene

Publications for CMIP Gene

  1. Truncation of C-mip (Tc-mip), a new proximal signaling protein, induces c-maf Th2 transcription factor and cytoskeleton reorganization. (PMID: 12939343) Grimbert P … Sahali D (The Journal of experimental medicine 2003) 2 3 4 22 60
  2. The Filamin-A is a partner of Tc-mip, a new adapter protein involved in c-maf-dependent Th2 signaling pathway. (PMID: 15128042) Grimbert P … Sahali D (Molecular immunology 2004) 3 4 22 60
  3. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11214970) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 2 3 4 60
  4. Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. (PMID: 22479202) Dastani Z … Kathiresan S (PLoS genetics 2012) 3 45 60
  5. Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians. (PMID: 22158537) Cho YS … Seielstad M (Nature genetics 2011) 3 45 60

Products for CMIP Gene

Sources for CMIP Gene

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