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Aliases for CMIP Gene

Aliases for CMIP Gene

  • C-Maf Inducing Protein 2 3
  • KIAA1694 4 6
  • Tc-Mip 3 4
  • TCMIP 3 4
  • Truncated C-Maf-Inducing Protein 4
  • C-Maf-Inducing Protein 3
  • C-Mip 4
  • T 6

External Ids for CMIP Gene

Previous GeneCards Identifiers for CMIP Gene

  • GC16P081258
  • GC16P080036
  • GC16P067234

Summaries for CMIP Gene

Entrez Gene Summary for CMIP Gene

  • This gene encodes a c-Maf inducing protein that plays a role in T-cell signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]

GeneCards Summary for CMIP Gene

CMIP (C-Maf Inducing Protein) is a Protein Coding gene. Among its related pathways are Cardiac Progenitor Differentiation and Regulation of Wnt-mediated beta catenin signaling and target gene transcription. GO annotations related to this gene include phospholipid binding.

UniProtKB/Swiss-Prot for CMIP Gene

  • Plays a role in T-cell signaling pathway. Isoform 2 may play a role in T-helper 2 (Th2) signaling pathway and seems to represent the first proximal signaling protein that links T-cell receptor-mediated signal to the activation of c-Maf Th2 specific factor.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CMIP Gene

Genomics for CMIP Gene

Regulatory Elements for CMIP Gene

Genomic Location for CMIP Gene

Start:
81,445,170 bp from pter
End:
81,711,762 bp from pter
Size:
266,593 bases
Orientation:
Plus strand

Genomic View for CMIP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CMIP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CMIP Gene

Proteins for CMIP Gene

  • Protein details for CMIP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IY22-CMIP_HUMAN
    Recommended name:
    C-Maf-inducing protein
    Protein Accession:
    Q8IY22
    Secondary Accessions:
    • Q9C0G9

    Protein attributes for CMIP Gene

    Size:
    773 amino acids
    Molecular mass:
    86331 Da
    Quaternary structure:
    • Interacts with FLNA.

    Alternative splice isoforms for CMIP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CMIP Gene

Proteomics data for CMIP Gene at MOPED

Post-translational modifications for CMIP Gene

  • Ubiquitination at Lys74 and Lys79
  • Modification sites at PhosphoSitePlus

Other Protein References for CMIP Gene

No data available for DME Specific Peptides for CMIP Gene

Domains for CMIP Gene

Protein Domains for CMIP Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for CMIP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IY22

UniProtKB/Swiss-Prot:

CMIP_HUMAN :
  • Q8IY22
Domain:
  • Contains 1 PH domain.
Similarity:
  • Contains 4 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with CMIP: view

No data available for Gene Families for CMIP Gene

Function for CMIP Gene

Molecular function for CMIP Gene

UniProtKB/Swiss-Prot Function: Plays a role in T-cell signaling pathway. Isoform 2 may play a role in T-helper 2 (Th2) signaling pathway and seems to represent the first proximal signaling protein that links T-cell receptor-mediated signal to the activation of c-Maf Th2 specific factor.

Gene Ontology (GO) - Molecular Function for CMIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20018188
genes like me logo Genes that share ontologies with CMIP: view

Phenotypes for CMIP Gene

MGI mutant phenotypes for CMIP:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with CMIP: view

Animal Model Products

CRISPR Products

miRNA for CMIP Gene

miRTarBase miRNAs that target CMIP

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CMIP

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for CMIP Gene

Localization for CMIP Gene

Subcellular locations from UniProtKB/Swiss-Prot for CMIP Gene

Nucleus. Cytoplasm. Note=Isoform 2 is translocated to the nucleus and is specifically recruited during minimal change nephrotic syndrome (MCNS). Detected in nuclear and cytoplasmic compartments during MCNS relapse. Expressed in cytoplasm only during MCNS remission and absent in normal patients.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CMIP Gene COMPARTMENTS Subcellular localization image for CMIP gene
Compartment Confidence
nucleus 5
cytosol 2
cytoskeleton 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CMIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with CMIP: view

Pathways for CMIP Gene

genes like me logo Genes that share pathways with CMIP: view

Pathways by source for CMIP Gene

1 Cell Signaling Technology pathway for CMIP Gene

Gene Ontology (GO) - Biological Process for CMIP Gene

None

Transcripts for CMIP Gene

Unigene Clusters for CMIP Gene

C-Maf inducing protein:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CMIP

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for CMIP

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CMIP Gene

No ASD Table

Relevant External Links for CMIP Gene

GeneLoc Exon Structure for
CMIP
ECgene alternative splicing isoforms for
CMIP

Expression for CMIP Gene

mRNA expression in normal human tissues for CMIP Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CMIP Gene

SOURCE GeneReport for Unigene cluster for CMIP Gene Hs.594095

mRNA Expression by UniProt/SwissProt for CMIP Gene

Q8IY22-CMIP_HUMAN
Tissue specificity: Isoform 1 is expressed in peripheral blood mononuclear cells and kidney. Lower expression in brain and liver. Expression is down-regulated in activated cells. Isoform 2 is expressed in lymphocyte precursors, however, expression shuts down during maturation and differentiation in thymus and fetal liver.
genes like me logo Genes that share expressions with CMIP: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for CMIP Gene

Orthologs for CMIP Gene

This gene was present in the common ancestor of chordates.

Orthologs for CMIP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CMIP 35
  • 99.65 (n)
  • 100 (a)
CMIP 36
  • 94 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CMIP 35
  • 94.21 (n)
  • 99.26 (a)
CMIP 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CMIP 35
  • 94.23 (n)
  • 98.96 (a)
CMIP 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cmip 35
  • 91.11 (n)
  • 98.58 (a)
Cmip 16
Cmip 36
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CMIP 36
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CMIP 36
  • 93 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cmip 35
  • 91.23 (n)
  • 98.7 (a)
chicken
(Gallus gallus)
Aves CMIP 35
  • 81.94 (n)
  • 92.84 (a)
CMIP 36
  • 95 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CMIP 36
  • 94 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.7889 35
tropical clawed frog
(Silurana tropicalis)
Amphibia cmip 35
  • 79.66 (n)
  • 91.06 (a)
Str.7218 35
zebrafish
(Danio rerio)
Actinopterygii cmip 35
  • 78.72 (n)
  • 86.85 (a)
cmip 36
  • 86 (a)
OneToOne
Dr.27534 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 41 (a)
OneToOne
Species with no ortholog for CMIP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CMIP Gene

ENSEMBL:
Gene Tree for CMIP (if available)
TreeFam:
Gene Tree for CMIP (if available)

Paralogs for CMIP Gene

No data available for Paralogs for CMIP Gene

Variants for CMIP Gene

Sequence variations from dbSNP and Humsavar for CMIP Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs2530 -- 81,568,146(+) TTCTA(C/G)GGCAC intron-variant
rs734119 -- 81,694,808(-) AACTA(C/G)AGTCT intron-variant
rs734120 -- 81,694,564(-) AAACT(A/G)TGGGT intron-variant
rs753107 -- 81,695,234(+) ctccc(G/T)tttcc intron-variant
rs753108 -- 81,695,376(+) TCGAT(A/G)AGGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CMIP Gene

Variant ID Type Subtype PubMed ID
esv34108 CNV Loss 18971310
esv23710 CNV Loss 19812545
nsv907010 CNV Loss 21882294
nsv518910 CNV Loss 19592680
nsv522140 CNV Gain 19592680
nsv521875 CNV Loss 19592680
nsv457576 CNV Loss 19166990
esv2714779 CNV Deletion 23290073
esv2714780 CNV Deletion 23290073
nsv526331 CNV Loss 19592680
nsv520382 CNV Loss 19592680
nsv1898 CNV Loss 18451855
nsv524589 CNV Loss 19592680
esv2325065 CNV Deletion 18987734
nsv510427 CNV Loss 20534489
esv2714781 CNV Deletion 23290073
esv3256 CNV Deletion 18987735
nsv907011 CNV Loss 21882294
esv2714782 CNV Deletion 23290073
esv2714783 CNV Deletion 23290073
dgv410e201 CNV Deletion 23290073
esv2714786 CNV Deletion 23290073
esv1774977 CNV Deletion 17803354
dgv411e201 CNV Deletion 23290073
esv2714789 CNV Deletion 23290073
nsv513456 CNV Insertion 21212237

Relevant External Links for CMIP Gene

HapMap Linkage Disequilibrium report
CMIP
Human Gene Mutation Database (HGMD)
CMIP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CMIP Gene

Disorders for CMIP Gene

(2) University of Copenhagen DISEASES for CMIP Gene

Relevant External Links for CMIP

Genetic Association Database (GAD)
CMIP
Human Genome Epidemiology (HuGE) Navigator
CMIP
genes like me logo Genes that share disorders with CMIP: view

No data available for UniProtKB/Swiss-Prot for CMIP Gene

Publications for CMIP Gene

  1. Truncation of C-mip (Tc-mip), a new proximal signaling protein, induces c-maf Th2 transcription factor and cytoskeleton reorganization. (PMID: 12939343) Grimbert P. … Sahali D. (J. Exp. Med. 2003) 2 3 4 23
  2. The Filamin-A is a partner of Tc-mip, a new adapter protein involved in c-maf-dependent Th2 signaling pathway. (PMID: 15128042) Grimbert P. … Sahali D. (Mol. Immunol. 2004) 3 4 23
  3. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11214970) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4
  4. CMIP and ATP2C2 modulate phonological short-term memory in language impairment. (PMID: 19646677) Newbury D.F. … Monaco A.P. (Am. J. Hum. Genet. 2009) 3 23
  5. Biological, clinical and population relevance of 95 loci for blood lipids. (PMID: 20686565) Teslovich T.M. … Kathiresan S. (Nature 2010) 3 48

Products for CMIP Gene

Sources for CMIP Gene

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