CMIP Gene
protein-coding GIFtS: 49
GCID: GC16P081478
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c-Maf inducing protein
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Aliases
for CMIP gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| C-Maf Inducing Protein1 2 | | Tc-Mip3 | | TCMIP2 3 | | C-Mip1 | | KIAA16943 5 | | Truncated C-Maf-Inducing Protein3 | | C-Maf-Inducing Protein2 | | T5 | | Tc-Mip3 | | |
Export aliases for CMIP gene to outside databasesPrevious GC identifers: GC16P081258 GC16P080036 GC16P067234 |
Summaries
for CMIP gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CMIP:
This gene encodes a c-Maf inducing protein that plays a role in T-cell signaling pathway. Alternatively splicedtranscript variants encoding different isoforms have been described for this gene. (provided by RefSeq, Aug 2011)
UniProtKB/Swiss-Prot: CMIP_HUMAN, Q8IY22Function: Plays a role in T-cell signaling pathway. Isoform 2 may play a role in T-helper 2 (Th2) signaling pathway andseems to represent the first proximal signaling protein that links T-cell receptor-mediated signal to the activationof c-Maf Th2 specific factor
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Genomic Views
for CMIP gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000016.9 NC_018927.1 NT_010498.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CMIP gene promoter:
NF-1 STAT1 AML1a STAT1beta STAT1alpha PPAR-alpha ZIC2/Zic2 Pax-4a ATF
Other transcription factors
Search SABiosciences Chromatin IP Primers for CMIP
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CMIP |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 16q23 Ensembl cytogenetic band: 16q23.2 HGNC cytogenetic band: 16q23CMIP Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 16 GeneLoc Exon Structure GeneLoc location for GC16P081478: view genomic region
(about GC identifiers)
Start:
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81,478,775 bp from pter |
End:
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81,745,367 bp from pter |
Size:
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266,593 bases |
Orientation:
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plus strand |
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Proteins
for CMIP gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CMIP_HUMAN, Q8IY22 (See
protein sequence)Recommended Name: C-Maf-inducing protein Size: 773 amino acids; 86331 Da
Subunit: Interacts with FLNA
Subcellular location: Nucleus. Cytoplasm. Note=Isoform 2 is translocated to the nucleus and is specifically recruitedduring minimal change nephrotic syndrome (MCNS). Detected in nuclear and cytoplasmic compartments during MCNS relapse.Expressed in cytoplasm only during MCNS remission and absent in normal patients
Developmental stage: Expressed in fetal liver
Secondary accessions: Q9C0G9Alternative splicing: 3 isoforms: Q8IY22-1 Q8IY22-2 Q8IY22-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for CMIP: NX_Q8IY22
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8IY22
CMIP Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_085132.1 NP_938204.2
ENSEMBL proteins: ENSP00000446100 ENSP00000440401 ENSP00000381120
Human Recombinant Protein Products for CMIP:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
CMIP for ontologies About GeneDecksing
CMIP Antibody Products:
Assay Products for CMIP: |
Protein
Domains /
Families
for CMIP gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CMIP for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q8IY22ProtoNet protein and cluster: Q8IY22 1 Blocks protein family: IPB001611 Leucine-rich repeat signature
UniProtKB/Swiss-Prot: CMIP_HUMAN, Q8IY22Similarity: Contains 4 LRR (leucine-rich) repeatsSimilarity: Contains 1 PH domain |
Function
for CMIP gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: CMIP_HUMAN, Q8IY22Function: Plays a role in T-cell signaling pathway. Isoform 2 may play a role in T-helper 2 (Th2) signaling pathway andseems to represent the first proximal signaling protein that links T-cell receptor-mediated signal to the activationof c-Maf Th2 specific factor Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005543 | phospholipid binding |
IEA | -- |
CMIP for ontologies About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CMIP (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CMIP (see all 3)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): CMIP (NM_030629) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CMIP | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CMIP |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CMIP |
|
Pathways & Interactions
for CMIP gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CMIP
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
4 Interacting proteins for CMIP (Q8IY222, 3 ENSP000003811204) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for CMIP gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CMIP
Search CenterWatch for drugs/clinical trials and news about CMIP
|
Transcripts
for CMIP gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CMIP gene (2 alternative transcripts): NM_030629.2 NM_198390.2 Unigene Cluster for CMIP: C-Maf inducing protein Hs.721240 [show with all ESTs]Unigene Representative Sequence: NM_19839011 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000537098(uc002fgp.3) ENST00000539778(uc002fgq.2 uc010vnq.2 uc002fgr.2)
ENST00000565029 ENST00000566513 ENST00000398040 ENST00000564666 ENST00000566462
ENST00000565680 ENST00000569146(uc010vnr.1) ENST00000568590 ENST00000561605
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CMIP (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CMIP (see all 3)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): CMIP (NM_030629) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CMIP | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CMIP |
Additional cDNA sequence: AB051481.1 AK056529.1 AK096598.1 AK304418.1 AK308869.1 AY172689.1 BC038113.1 BC128554.1 14 DOTS entries: DT.455097 DT.91769903 DT.120661266 DT.100784710 DT.100029229 DT.100784713 DT.91985535 DT.91769898 DT.95260338 DT.95271749 DT.208136 DT.92000622 DT.100661847 DT.99963541 24/168 AceView cDNA sequences (see all 168): AI672844 CB216098 AI796389 BU739719 CA310555 BX281877 CD678503 AI017261 BQ889937 AW242895 BQ022032 BG109003 AI863263 AA302279 NM_030629 BE503119 BM682878 CR594637 AA327188 AY172689 AI825144 CK299416 BQ010025 AI719510
GeneLoc Exon Structure
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Expression
for CMIP gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CMIP expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCACCTTTCC
About this image
See CMIP Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CMIP
SOURCE GeneReport for Unigene cluster: Hs.721240
UniProtKB/Swiss-Prot: CMIP_HUMAN, Q8IY22Tissue specificity: Isoform 1 is expressed in peripheral blood mononuclear cells and kidney. Lower expression in brainand liver. Expression is down-regulated in activated cells. Isoform 2 is expressed in lymphocyte precursors, however,expression shuts down during maturation and differentiation in thymus and fetal liver
SABiosciences Custom PCR Arrays for CMIP
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CMIP
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CMIP | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CMIP | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CMIP | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CMIP |
Orthologs
for CMIP gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for CMIP gene from 6/18 species (see all 18) About this table
ENSEMBL Gene Tree for CMIP (if available)
TreeFam Gene Tree for CMIP (if available) |
Paralogs
for CMIP gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for CMIP gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 16 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CMIP (81478775 - 81728775 bp, first 250kb of CMIP)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 5 variations for CMIP
3 CNVs: 88245 67061 47895
2 Indels: 41749 45470
Human Gene Mutation Database (HGMD): CMIP
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CMIP |
|
Disorders
/ Diseases
for CMIP gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CMIP for disorders About GeneDecksing
OMIM gene information: 610112
OMIM disorders: --
5  diseases for CMIP: About MalaCardsnewcastle disease dyslexia nephrotic syndrome hodgkin's lymphoma
proteinuria
2 diseases from the University of Copenhagen DISEASES database for CMIP:Nephrotic syndrome Dyslexia Human Genome Epidemiology (HuGE) Navigator: CMIP (2 documents)
Export disorders for CMIP gene to outside databases
|
Publications
for CMIP gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CMIP gene, integrated from 9 sources (see all 30):
(articles sorted by number of sources associating them with CMIP) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Truncation of C-mip (Tc-mip), a new proximal signaling protein, induces c-maf Th2 transcription factor and cytoskeleton reorganization. (PubMed id 12939343)1, 2, 3, 9 Grimbert P....Sahali D. (2003)
- Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11214970)1, 2, 3 Nagase T.... Ohara O. (2000)
- The Filamin-A is a partner of Tc-mip, a new adapter protein involved in c-maf-dependent Th2 signaling pathway. (PubMed id 15128042)1, 2, 9 Grimbert P....Sahali D. (2004)
- CMIP and ATP2C2 modulate phonological short-term memo ry in language impairment. (PubMed id 19646677)1, 9 Newbury D.F....Monaco A.P. (2009)
- c-mip down-regulates NF-kB activity and promotes apopt osis in podocytes. (PubMed id 22507836)1 Ory V....Sahali D. (2012)
- Meta-analysis of genome-wide association studies ident ifies eight new loci for type 2 diabetes in east Asians. (PubMed id 22158537)1 Cho Y.S....Seielstad M. (2012)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. (PubMed id 22479202)1 Dastani Z....Kathiresan S. (2012)
- Hearing function and thresholds: a genome-wide associ ation study in European isolated populations identifies new loci and pathways. (PubMed id 21493956)1 Girotto G....Gasparini P. (2011)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
|
External Searches for CMIP gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing CMIP gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CMIP gene
(According to HUGE)
About This Section
| |
Specialized Databases showing CMIP gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for CMIP gene:
Search GeneIP for patents involving CMIP
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CMIP gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for CMIP | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CMIP | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CMIP | | | OriGene Protein Over-expression Lysate for CMIP | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CMIP | | OriGene 3'-UTR Clone for CMIP | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CMIP | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CMIP | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for CMIP | | OriGene Custom Protein Services for CMIP | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CMIP | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CMIP | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CMIP | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CMIP | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CMIP | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CMIP |
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 | | | CMIP Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CMIP |
|  |  |  |  | | | | Search ThermoFisher Antibodies for CMIP |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CMIP |
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