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Aliases for CMC4 Gene

Aliases for CMC4 Gene

  • C-X(9)-C Motif Containing 4 2 3
  • Mature T-Cell Proliferation 1 Neighbor Protein 3 4
  • Mature T-Cell Proliferation-1 Type A 3 4
  • Mature T-Cell Proliferation 1 2 3
  • Protein P8 MTCP-1 3 4
  • MTCP-1 Type A 3 4
  • P8MTCP1 3 4
  • MTCP1NB 3 4
  • C6.1B 3 4
  • MTCP1 3 4
  • C-X(9)-C Motif Containing 4 Homolog (S. Cerevisiae) 2
  • Mature T-Cell Proliferation 1 Neighbor 2
  • C-X(9)-C Motif Containing 4 Homolog 3
  • Cx9C Motif-Containing Protein 4 3
  • Isoform P8 2
  • MTCP1B 3
  • P8 3

External Ids for CMC4 Gene

Previous Symbols for CMC4 Gene

  • MTCP1

Summaries for CMC4 Gene

Entrez Gene Summary for CMC4 Gene

  • This gene was identified by involvement in some t(X;14) translocations associated with mature T-cell proliferations. This region has a complex gene structure, with a common promoter and 5' exon spliced to two different sets of 3' exons that encode two different proteins. This gene represents the downstream 8 kDa protein that localizes to mitochondria.[provided by RefSeq, Mar 2009]

GeneCards Summary for CMC4 Gene

CMC4 (C-X(9)-C Motif Containing 4) is a Protein Coding gene. Among its related pathways are PI3K-Akt signaling pathway.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CMC4 Gene

Genomics for CMC4 Gene

Genomic Location for CMC4 Gene

155,061,622 bp from pter
155,071,362 bp from pter
9,741 bases
Minus strand

Genomic View for CMC4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CMC4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CMC4 Gene

No data available for Regulatory Elements for CMC4 Gene

Proteins for CMC4 Gene

  • Protein details for CMC4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cx9C motif-containing protein 4
    Protein Accession:
    Secondary Accessions:
    • Q5HYP9

    Protein attributes for CMC4 Gene

    68 amino acids
    Molecular mass:
    7747 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CMC4 Gene

    Alternative splice isoforms for CMC4 Gene


neXtProt entry for CMC4 Gene

Proteomics data for CMC4 Gene at MOPED

Post-translational modifications for CMC4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CMC4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CMC4 Gene

Domains for CMC4 Gene

Protein Domains for CMC4 Gene



  • The twin Cx9C motifs are involved in the recognition by the mitochondrial disulfide relay system.:
    • P56277
  • Belongs to the CMC4 family.:
    • P56277
genes like me logo Genes that share domains with CMC4: view

No data available for Gene Families for CMC4 Gene

Function for CMC4 Gene

miRNA for CMC4 Gene

miRTarBase miRNAs that target CMC4

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for CMC4 Gene

Localization for CMC4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CMC4 Gene


Gene Ontology (GO) - Cellular Components for CMC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA --
genes like me logo Genes that share ontologies with CMC4: view

Pathways for CMC4 Gene

SuperPathways for CMC4 Gene

Superpath Contained pathways
1 PI3K-Akt signaling pathway
genes like me logo Genes that share pathways with CMC4: view

Pathways by source for CMC4 Gene

1 KEGG pathway for CMC4 Gene

Interacting Proteins for CMC4 Gene

Selected Interacting proteins: P56277-CMC4_HUMAN for CMC4 Gene via I2D

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for CMC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008283 cell proliferation TAS 8361760
genes like me logo Genes that share ontologies with CMC4: view

Transcripts for CMC4 Gene

mRNA/cDNA for CMC4 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CMC4 Gene

C-x(9)-C motif containing 4 homolog (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CMC4 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b
SP2: -
SP3: - - - - - -

Relevant External Links for CMC4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CMC4 Gene

mRNA expression in normal human tissues for CMC4 Gene

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for CMC4 Gene

SOURCE GeneReport for Unigene cluster for CMC4 Gene Hs.6917

mRNA Expression by UniProt/SwissProt for CMC4 Gene

Tissue specificity: Expressed in many tissues with a relatively high level in skeletal muscle
genes like me logo Genes that share expressions with CMC4: view

Orthologs for CMC4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CMC4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CMC4 36
  • 99.02 (n)
  • 97.06 (a)
CMC4 37
  • 97 (a)
(Bos Taurus)
Mammalia CMC4 37
  • 82 (a)
  • 92.19 (n)
  • 87.5 (a)
(Canis familiaris)
Mammalia -- 37
  • 78 (a)
-- 37
  • 88 (a)
CMC4 36
  • 92.45 (n)
  • 92.45 (a)
(Mus musculus)
Mammalia Mtcp1 36
  • 86.76 (n)
  • 88.24 (a)
Mtcp1 37
  • 88 (a)
(Rattus norvegicus)
Mammalia LOC102546764 36
  • 71.57 (n)
  • 66.18 (a)
(Gallus gallus)
Aves CMC4 37
  • 76 (a)
  • 76.92 (n)
  • 80 (a)
(Anolis carolinensis)
Reptilia CMC4 37
  • 69 (a)
(Danio rerio)
Actinopterygii cmc4 37
  • 56 (a)
Species with no ortholog for CMC4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CMC4 Gene

Gene Tree for CMC4 (if available)
Gene Tree for CMC4 (if available)

Paralogs for CMC4 Gene

No data available for Paralogs for CMC4 Gene

Variants for CMC4 Gene

Sequence variations from dbSNP and Humsavar for CMC4 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs2000326 -- 155,061,856(+) GAAGT(A/C/G/T)TGCAT missense, reference
rs3060678 -- 155,061,439(-) ttttt(-/TT)gagat downstream-variant-500B
rs11279530 -- 155,063,039(+) CAAAC(-/AAGGT)AAGGT intron-variant
rs35143146 -- 155,062,529(+) AAAGC(C/G)TAAAA intron-variant
rs73569627 -- 155,062,044(+) GTACA(A/G)GGAGG intron-variant

Relevant External Links for CMC4 Gene

HapMap Linkage Disequilibrium report

No data available for Structural Variations from Database of Genomic Variants (DGV) for CMC4 Gene

Disorders for CMC4 Gene


  • Note=Overexpressed in T-cell leukemia bearing a t(X;14) translocation.

No disorders were found for CMC4 Gene.

Publications for CMC4 Gene

  1. MTCP-1: a novel gene on the human chromosome Xq28 translocated to the T cell receptor alpha/delta locus in mature T cell proliferations. (PMID: 8361760) Stern M.-H. … Kirsch I.R. (Oncogene 1993) 2 3 4
  2. Solution structure of human p8MTCP1, a cysteine-rich protein encoded by the MTCP1 oncogene, reveals a new alpha-helical assembly motif. (PMID: 9405159) Barthe P. … Roumestand C. (J. Mol. Biol. 1997) 2 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. The 8 kD product of the putative oncogene MTCP-1 is a mitochondrial protein. (PMID: 7784073) Madani A. … Stern M.-H. (Oncogene 1995) 3 4
  5. Genome-wide analysis of eukaryotic twin CX9C proteins. (PMID: 20922212) Cavallaro G. (Mol Biosyst 2010) 2 3

Products for CMC4 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate CMC4
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for CMC4
    • Block miRNA regulation of CMC4 using miScript Target Protectors

    Sources for CMC4 Gene

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