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Aliases for CMC2 Gene

Aliases for CMC2 Gene

  • C-X(9)-C Motif Containing 2 2 3
  • C16orf61 3 4
  • COX Assembly Mitochondrial Protein 2 Homolog (S. Cerevisiae) 2
  • COX Assembly Mitochondrial Protein 2 Homolog 3
  • Chromosome 16 Open Reading Frame 61 2
  • 2310061C15Rik 3
  • DC13 3

External Ids for CMC2 Gene

Previous Symbols for CMC2 Gene

  • C16orf61

Summaries for CMC2 Gene

GeneCards Summary for CMC2 Gene

CMC2 (C-X(9)-C Motif Containing 2) is a Protein Coding gene.

UniProtKB/Swiss-Prot for CMC2 Gene

  • May be involved in cytochrome c oxidase biogenesis.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CMC2 Gene

Genomics for CMC2 Gene

Genomic Location for CMC2 Gene

Start:
80,966,448 bp from pter
End:
81,020,270 bp from pter
Size:
53,823 bases
Orientation:
Minus strand

Genomic View for CMC2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CMC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CMC2 Gene

No data available for Regulatory Elements for CMC2 Gene

Proteins for CMC2 Gene

  • Protein details for CMC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NRP2-COXM2_HUMAN
    Recommended name:
    COX assembly mitochondrial protein 2 homolog
    Protein Accession:
    Q9NRP2
    Secondary Accessions:
    • D3DUK6

    Protein attributes for CMC2 Gene

    Size:
    79 amino acids
    Molecular mass:
    9460 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CMC2 Gene

Proteomics data for CMC2 Gene at MOPED

Post-translational modifications for CMC2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CMC2 Gene

Domains for CMC2 Gene

Protein Domains for CMC2 Gene

UniProtKB/Swiss-Prot:

COXM2_HUMAN
Family:
  • Belongs to the CMC family.:
    • Q9NRP2
genes like me logo Genes that share domains with CMC2: view

No data available for Gene Families for CMC2 Gene

Function for CMC2 Gene

Molecular function for CMC2 Gene

UniProtKB/Swiss-Prot Function: May be involved in cytochrome c oxidase biogenesis.

Phenotypes for CMC2 Gene

genes like me logo Genes that share phenotypes with CMC2: view

miRNA for CMC2 Gene

miRTarBase miRNAs that target CMC2

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targeting and HOMER Transcription for CMC2 Gene

Localization for CMC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CMC2 Gene

Mitochondrion.

Gene Ontology (GO) - Cellular Components for CMC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA 20220131
genes like me logo Genes that share ontologies with CMC2: view

Pathways for CMC2 Gene

SuperPathways for CMC2 Gene

No Data Available

Interacting Proteins for CMC2 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000219400%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000418348%0d%0a9606.ENSP00000297151%0d%0a
Selected Interacting proteins: ENSP00000219400 for CMC2 Gene via STRING

Gene Ontology (GO) - Biological Process for CMC2 Gene

None

No data available for Pathways by source for CMC2 Gene

Transcripts for CMC2 Gene

mRNA/cDNA for CMC2 Gene

Unigene Clusters for CMC2 Gene

COX assembly mitochondrial protein 2 homolog (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CMC2 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e · 6f
SP1: - - -
SP2:
SP3: - - - -
SP4: - - -
SP5: -
SP6: -
SP7: - - - - -
SP8: - - - - - -

Relevant External Links for CMC2 Gene

GeneLoc Exon Structure for
CMC2
ECgene alternative splicing isoforms for
CMC2

Expression for CMC2 Gene

mRNA expression in normal human tissues for CMC2 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CMC2 Gene

SOURCE GeneReport for Unigene cluster for CMC2 Gene Hs.55028

genes like me logo Genes that share expressions with CMC2: view

Orthologs for CMC2 Gene

This gene was present in the common ancestor of animals.

Orthologs for CMC2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CMC2 36
  • 99.16 (n)
  • 98.73 (a)
CMC2 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CMC2 36
  • 93.59 (n)
  • 87.18 (a)
CMC2 37
  • 86 (a)
OneToMany
CMC2 37
  • 86 (a)
OneToMany
dog
(Canis familiaris)
Mammalia CMC2 37
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cmc2 36
  • 81.01 (n)
  • 82.28 (a)
Cmc2 16
Cmc2 37
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 74 (a)
OneToMany
-- 37
  • 86 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Cmc2 36
  • 87.34 (n)
  • 81.01 (a)
chicken
(Gallus gallus)
Aves C16ORF61 36
  • 71.11 (n)
  • 65.33 (a)
C16ORF61 37
  • 65 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CMC2 37
  • 73 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.10954 36
tropical clawed frog
(Silurana tropicalis)
Amphibia cmc2 36
  • 62.82 (n)
  • 57.69 (a)
Str.29 36
zebrafish
(Danio rerio)
Actinopterygii cmc2 36
  • 59.21 (n)
  • 61.84 (a)
cmc2 37
  • 60 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG42375 37
  • 39 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea C35D10.17 37
  • 26 (a)
OneToOne
Species with no ortholog for CMC2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CMC2 Gene

ENSEMBL:
Gene Tree for CMC2 (if available)
TreeFam:
Gene Tree for CMC2 (if available)

Paralogs for CMC2 Gene

genes like me logo Genes that share paralogs with CMC2: view

No data available for Paralogs for CMC2 Gene

Variants for CMC2 Gene

Sequence variations from dbSNP and Humsavar for CMC2 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs12045 -- 80,997,401(-) CATCT(C/T)CTAAA utr-variant-5-prime, reference, synonymous-codon
rs13609 -- 80,976,138(+) CGCAT(G/T)GCAAT reference, synonymous-codon, utr-variant-3-prime
rs1127390 -- 80,976,176(-) AGTAC(A/G)TAGAA missense, reference, utr-variant-3-prime
rs1469123 -- 80,995,944(+) TTTTA(A/G)AATCC intron-variant
rs1469124 -- 80,996,049(+) AAAAA(C/G)AGTCA intron-variant

Relevant External Links for CMC2 Gene

HapMap Linkage Disequilibrium report
CMC2
Human Gene Mutation Database (HGMD)
CMC2

No data available for Structural Variations from Database of Genomic Variants (DGV) for CMC2 Gene

Disorders for CMC2 Gene

No disorders were found for CMC2 Gene.

No data available for UniProtKB/Swiss-Prot for CMC2 Gene

Publications for CMC2 Gene

  1. The conserved mitochondrial twin Cx9C protein Cmc2 Is a Cmc1 homologue essential for cytochrome c oxidase biogenesis. (PMID: 20220131) Horn D. … Barrientos A. (J. Biol. Chem. 2010) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Fine mapping and association studies of a high-density lipoprotein cholesterol linkage region on chromosome 16 in French-Canadian subjects. (PMID: 19844255) Dastani Z. … Genest J. (Eur. J. Hum. Genet. 2010) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3

Products for CMC2 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate CMC2
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for CMC2
    • Block miRNA regulation of CMC2 using miScript Target Protectors

    Sources for CMC2 Gene

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